Publication Information

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'abstract_inverted_index': {'Cardiac': [0, 201], 'troponin': [1, 10, 80, 86, 144, 202, 211, 281, 287, 345, 405, 407, 409, 726, 762, 787, 791, 1487, 1912, 2004, 2016, 2278, 2311, 2439, 2516, 3065, 3115, 3135, 3235, 3295, 3349, 3409, 3433, 3514, 3534, 3549, 3554, 3562, 3577, 3607, 3615, 3649, 3689, 3723, 4533, 4553, 4641], 'I': [2, 203, 406, 727, 754, 1488], '(cTnI)': [3, 204, 728], 'is': [4, 13, 205, 214, 426, 603, 756, 765, 888, 1005, 1050, 1063, 1100, 1521, 3246, 3270, 3312, 3316, 3865, 4288], 'the': [5, 9, 16, 28, 44, 104, 112, 115, 147, 156, 190, 206, 210, 217, 229, 245, 305, 313, 316, 348, 357, 391, 432, 494, 499, 588, 592, 599, 604, 717, 724, 747, 757, 761, 768, 797, 818, 826, 833, 875, 883, 1006, 1019, 1023, 1027, 1035, 1042, 1073, 1078, 1091, 1103, 1110, 1123, 1128, 1187, 1226, 1234, 1272, 1283, 1350, 1395, 1439, 1447, 1514, 1517, 1524, 1534, 1538, 1550, 1553, 1619, 1622, 1636, 1689, 1726, 1769, 1803, 1823, 1972, 2003, 2014, 2073, 2083, 2264, 2275, 2294, 2306, 2333, 2341, 2362, 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4465, 4474, 4500, 4546, 4589, 4690], 'calcium': [17, 91, 116, 158, 176, 218, 292, 317, 359, 377, 628, 635, 1409, 3694, 3707], 'control': [18, 219], 'heart': [20, 221, 474], 'muscle': [21, 222, 772, 1021, 1114, 1197, 2133, 2139, 4308, 4354], 'contraction.': [22, 223], 'Recently,': [23, 224], 'specific': [24, 225, 2634], 'missense': [25, 226, 496, 732], 'mutations': [26, 50, 59, 181, 227, 251, 260, 382, 531, 611, 618, 722, 733, 1528, 1609, 1691, 4294], 'cTnI': [29, 71, 230, 272, 972, 1014, 1054, 1062, 1452, 1497, 1643, 3281, 3309, 4203], 'gene': [30, 231, 503, 538, 729, 973], '(TNNI3)': [31, 232], 'have': [32, 42, 233, 243, 532, 596, 911, 1205, 1492, 3254, 3404, 3653, 3667, 4459], 'been': [33, 234, 534, 1321, 1336, 1444, 4461], 'shown': [34, 235, 912, 1269, 1337, 1383, 2087, 3651, 3721, 3866, 3975, 4162, 4188, 4242], 'to': [35, 126, 155, 236, 327, 356, 490, 719, 796, 832, 879, 919, 1018, 1052, 1071, 1088, 1184, 1192, 1212, 1239, 1323, 1338, 1481, 1498, 1545, 1592, 1687, 1767, 1932, 2065, 2068, 2072, 2088, 2103, 2466, 2476, 2618, 2704, 2752, 2778, 2817, 2839, 2876, 2936, 2950, 2957, 2977, 3034, 3098, 3124, 3183, 3205, 3318, 3426, 3437, 3447, 3460, 3477, 3487, 3521, 3535, 3544, 3565, 3622, 3652, 3666, 3822, 3929, 3969, 3976, 3994, 4002, 4012, 4024, 4048, 4087, 4243, 4359, 4369, 4469, 4472, 4489, 4540, 4635], 'cause': [36, 183, 237, 384, 1489, 4206], 'familial': [37, 238], 'hypertrophic': [38, 239, 402, 423], 'cardiomyopathy': [39, 240, 403, 424], '(HCM).': [40, 241], 'We': [41, 242, 2941], 'analyzed': [43, 244, 2484, 2777, 2816, 2942, 3787], 'functional': [45, 246, 589, 1059, 1586, 4219], 'effects': [46, 247], 'two': [48, 249, 1028, 1508, 1525, 1640, 4201, 4341, 4375], 'HCM': [49, 184, 199, 250, 385, 400, 593, 1509, 1527, 1773, 3245, 3280, 3335, 4207, 4376, 4647, 4697], '(R145G': [51, 252], 'R162W)': [53, 254], 'using': [54, 70, 76, 255, 271, 277, 1758, 1825, 1935, 1966, 2007, 2109, 2194, 2236, 2328, 2340, 2487, 2495, 2524, 2606, 2829, 3042, 3210, 3492, 3530, 3610, 3629, 3791, 3914, 3937], 'purified': [55, 256, 1494, 1821, 1887, 3043], 'recombinant': [56, 257, 1495, 1922, 3044, 3816], 'cTnI.': [57, 258], 'Both': [58, 84, 259, 285, 1814, 2906, 4235], 'gave': [60, 261, 3155, 3168, 4559], 'reduced': [61, 262, 1407, 1590, 2951, 4494], 'inhibition': [62, 113, 173, 263, 314, 374, 1079, 1104, 1220, 1291, 2857, 2893, 2902, 2919, 2931, 2947, 3014, 3158, 3172, 3189, 3227, 4260, 4322, 4368, 4497, 4561, 4584, 4628], 'actin-tropomyosin-activated': [64, 265], 'myosin': [65, 266, 622, 843, 1082, 1107, 1595, 2230, 2241, 2860, 3076, 3139, 3418, 3591, 4250, 4528], 'ATPase,': [66, 267, 2300], 'both': [67, 268, 775, 803, 1116, 2933, 2973, 3230, 3283, 3972, 4262, 4293, 4357], 'experiments': [69, 270, 3209], 'alone': [72, 273, 4588], 'those': [75, 276, 2753, 3277, 3930], 'reconstituted': [77, 278, 1914, 2015, 3039, 3064], 'human': [78, 279, 971, 1188, 1215, 1284, 1496, 1895, 1910, 3045, 4202, 4644], 'cardiac': [79, 280, 404, 725, 778, 1036, 1189, 1285, 1329, 1440, 1832, 1896, 1911, 2138, 3046, 3333, 4476, 4645], 'under': [81, 282, 2279, 2963, 3144, 3971, 4117, 4132, 4174], 'relaxing': [82, 283, 2282], 'conditions.': [83, 284], 'mutant': [85, 100, 138, 163, 286, 301, 339, 364, 594, 1624, 1818, 2084, 2114, 2867, 2955, 3020, 3056, 3083, 3120, 3153, 3166, 3203, 3234, 3261, 3287, 3313, 3336, 3355, 3366, 3449, 3483, 3513, 3548, 3597, 3606, 3736, 3750, 3835, 4085, 4222, 4284, 4506, 4552, 4573, 4597, 4648, 4698], 'complexes': [87, 288, 2085, 3037, 3084, 3204, 3501], 'also': [88, 165, 289, 366, 1086, 1443, 3517, 3527, 3690, 4217], 'conferred': [89, 118, 290, 319, 2862, 3015, 3078, 3228, 3645], 'increased': [90, 141, 157, 175, 291, 342, 358, 376, 476, 1627, 3669, 3693, 3706, 3762, 4008, 4058], 'sensitivity': [92, 117, 159, 177, 293, 318, 360, 378, 629, 636, 1602, 3671, 3695, 3708, 3740, 3763], 'ATPase': [94, 295, 1108, 1596, 1604, 2232, 2254, 2427, 2861, 2885, 2964, 3077, 3108, 3140, 3419, 3464, 3467, 3509, 3592, 4251, 4529], 'regulation.': [95, 296], 'Studies': [96, 297], 'on': [97, 298, 1201, 2406, 2531, 3416, 4211, 4295], 'wild': [98, 105, 127, 299, 306, 328, 1504, 1815, 2092, 2111, 2864, 2873, 2937, 2969, 2985, 3017, 3053, 3080, 3095, 3133, 3161, 3200, 3231, 3256, 3284, 3369, 3413, 3495, 3552, 3575, 3594, 3603, 3647, 3685, 3733, 3746, 3771, 3830, 3859, 3915, 3982, 4029, 4082, 4113, 4128, 4170, 4224, 4253, 4268, 4541, 4549, 4568, 4594], 'type/R145G': [99, 300, 3576], 'mixtures': [101, 302, 3350, 3493, 3600], 'showed': [102, 135, 303, 336, 3502, 3691, 3737, 3759], 'that': [103, 111, 136, 179, 304, 312, 337, 380, 598, 913, 1223, 1270, 1384, 1529, 1607, 1621, 2105, 2968, 2983, 3006, 3150, 3185, 3224, 3272, 3311, 3345, 3537, 3743, 3760, 3980, 4205, 4227, 4266, 4370, 4590], 'type': [106, 128, 307, 329, 1505, 1816, 2061, 2112, 2865, 2874, 2938, 2970, 3018, 3054, 3081, 3096, 3134, 3162, 3201, 3232, 3257, 3285, 3370, 3496, 3553, 3595, 3648, 3686, 3734, 3747, 3772, 3831, 3916, 3983, 4030, 4083, 4114, 4129, 4171, 4225, 4254, 4269, 4542, 4550, 4569, 4595], 'phenotype': [107, 308, 1449], 'was': [108, 123, 309, 324, 493, 1681, 1723, 1756, 1898, 1913, 1930, 1991, 2005, 2018, 2063, 2077, 2101, 2326, 2359, 2400, 2451, 2493, 2505, 2522, 2556, 2584, 2604, 2616, 2702, 2714, 2805, 2827, 2837, 2869, 2998, 3085, 3122, 3148, 3239, 3439, 3450, 3541, 3563, 3579, 3650, 3664, 3720, 3764, 3786, 3818, 3836, 3974, 4000, 4022, 4054, 4275], 'dominant': [109, 310, 429, 3249], 'by': [119, 320, 1046, 1122, 1341, 1446, 1563, 1683, 1698, 1915, 1993, 2020, 2023, 2142, 2361, 2375, 2485, 2560, 2586, 2642, 2755, 2863, 3016, 3028, 3067, 3079, 3141, 3193, 3229, 3452, 3469, 3551, 3593, 3646, 3722, 4575], 'a': [120, 321, 437, 744, 783, 814, 823, 975, 1030, 1064, 1207, 1230, 1241, 1347, 1451, 1542, 1546, 1670, 1759, 1901, 1917, 1967, 2118, 2195, 2313, 2488, 2525, 2569, 2623, 2645, 2693, 2707, 2809, 2879, 3194, 3264, 3279, 3332, 3503, 3522, 3611, 3654, 3697, 3710, 3738, 3792, 3823, 3839, 3904, 3933, 4007, 4013, 4021, 4057, 4183, 4277, 4289, 4305, 4313, 4445, 4449, 4466, 4492, 4643], '50:50': [121, 322, 3682, 3730], 'mixture': [122, 323, 2450, 2474, 3683, 3731], 'more': [124, 325, 3320, 4315, 4600], 'similar': [125, 326, 2935, 3928, 4361, 4493, 4539, 4634], 'than': [129, 189, 330, 390, 3321, 4252], 'expected.': [130, 331], 'Surface': [131, 332], 'plasmon': [132, 333, 3794], 'resonance-based': [133, 334], 'assays': [134, 335, 2284, 2301, 2961, 3180], 'R162W': [137, 338, 1539, 1623, 1772, 2909, 3119, 3152, 3498, 3726, 3775, 3993, 4046, 4239, 4505, 4572], 'had': [139, 340], 'an': [140, 341, 427, 921, 1097, 1598, 1626, 2528, 2899, 3101, 3247, 3453, 3692], 'affinity': [142, 343, 1628], 'for': [143, 344, 1077, 1218, 1233, 1629, 1999, 2446, 2457, 2562, 2706, 2932, 2984, 3858, 4078, 4373, 4567], 'C': [145, 346, 408, 788, 4033], 'presence': [148, 349, 1092, 1129, 2265, 2307, 2431, 3909], 'calcium.': [150, 351], 'This': [151, 352, 1084, 1333, 3003, 4193, 4274], 'observation': [152, 353], 'may': [153, 182, 354, 383, 1610, 4228], 'contribute': [154, 355], 'found': [160, 361, 535, 2064, 2506, 2967, 3123, 3149, 3665, 4001, 4023, 4055, 4358], 'with': [161, 194, 362, 395, 436, 743, 786, 802, 830, 924, 1222, 1225, 1236, 1507, 2070, 2558, 2568, 2610, 2638, 2681, 2716, 2852, 2890, 2916, 3160, 3176, 3696, 3783, 4256, 4417, 4448, 4503, 4531, 4565, 4582, 4586], 'this': [162, 363, 537, 1388, 2106, 2654, 3023, 3761, 4430, 4501], 'corroborates': [166, 367], 'recent': [167, 368, 1380, 1632], 'structural': [168, 369, 1633], 'data.': [169, 370], 'The': [170, 371, 472, 486, 780, 808, 871, 970, 1056, 1176, 1435, 1585, 1721, 1753, 1775, 1891, 1928, 1958, 2011, 2322, 2357, 2449, 2699, 2711, 2799, 2834, 2856, 3058, 3071, 3424, 3489, 3570, 3586, 3642, 3779, 3827, 3964, 4298, 4411, 4612, 4686], 'observed': [171, 372, 4499], 'decreased': [172, 373, 627, 1965], 'suggest': [178, 379, 1606], 'these': [180, 381, 1608, 1639, 2499, 2944, 3145, 3557], 'via': [185, 386, 800], 'impaired': [186, 191, 387, 392], 'relaxation': [187, 388, 1111, 1613], 'rather': [188, 389], 'contraction': [192, 393, 773], 'seen': [193, 394, 3582], 'some': [195, 396, 610, 625], 'other': [196, 397, 542, 1518], 'classes': [197, 398], 'mutants.': [200, 401], 'T': [410, 792], 'tropomyosin': [411, 806], 'dithiothreitol': [412], '1,4-piperazinediethanesulfonic': [413], 'acid': [414, 416, 2367, 4344, 4452], '4-morpholinepropanesulfonic': [415], 'subfragment': [417], '1': [418, 1943, 1955, 1985, 2249, 2329, 2420, 2599, 2687, 2727, 2980, 3531, 3631, 3850, 4051, 4272], 'polyacrylamide': [419, 2490], 'gel': [420, 2098], 'electrophoresis': [421], 'Familial': [422], '(HCM)1': [425], 'autosomal': [428, 3248], 'disease': [430, 602, 3250], 'myocardium.': [433], 'Patients': [434], 'present': [435, 2999, 4605], 'wide': [438], 'range': [439, 2314, 3840], 'symptoms': [441], 'including': [442], 'chest': [443], 'pain,': [444], 'dyspnea,': [445], 'syncope,': [446], 'stroke,': [447], 'sudden': [449], 'death': [450], '(1.Maron': [451], 'B.J.': [452, 2216], 'Gardin': [453], 'J.M.': [454, 456], 'Flack': [455], 'Gidding': [457], 'S.S.': [458, 2146], 'Kurosaki': [459], 'T.T.': [460], 'Bild': [461], 'D.E.': [462], 'Circulation.': [463], '1995;': [464], '92:': [465], '785-789Crossref': [466], 'PubMed': [467, 525, 565, 581, 648, 711, 852, 866, 900, 936, 967, 999, 1152, 1171, 1259, 1311, 1374, 1430, 1474, 1580, 1663, 1716, 1745, 1797, 1859, 1879, 2055, 2154, 2168, 2186, 2224, 2395, 2550, 2771, 3397, 3810, 3959, 4337, 4406, 4520, 4681], 'Scopus': [468, 526, 566, 582, 649, 712, 853, 867, 901, 937, 1000, 1153, 1172, 1260, 1312, 1375, 1431, 1475, 1581, 1664, 1717, 1746, 1798, 1860, 1880, 2056, 2155, 2169, 2225, 2551, 2772, 3398, 3811, 3960, 4407, 4521, 4682], '(1599)': [469], 'Google': [470, 528, 568, 584, 651, 714, 855, 869, 903, 939, 968, 1002, 1155, 1174, 1262, 1314, 1377, 1433, 1477, 1583, 1666, 1719, 1748, 1800, 1862, 1882, 2058, 2157, 2171, 2187, 2227, 2396, 2553, 2774, 3400, 3813, 3962, 4338, 4409, 4523, 4684], 'Scholar).': [471, 585, 652, 870, 904, 969, 1175, 1263, 1315, 1378, 1434, 1478, 1584, 1720, 2059, 2188, 2228, 2356, 2397, 2554, 3401, 3814, 3963, 4339, 4410, 4524, 4685], 'affected': [473, 3252], 'shows': [475, 2982, 3005], 'left': [477], 'ventricular': [478, 1401], 'mass,': [479], 'myocyte': [480, 1404], 'hypertrophy': [481], 'disarray,': [483], 'fibrosis.': [485], 'first': [487, 718], 'HCM-causing': [488, 721], 'mutation': [489, 497, 745, 1540, 3282, 4303, 4480], 'be': [491, 880, 1120, 1339, 2066, 2089, 3319, 3359, 3518, 3977, 4003, 4025, 4244], 'reported': [492, 741, 1526, 4371], 'R403Q': [495], 'β-myosin': [500], 'heavy': [501, 623], 'chain': [502, 1685, 1762], '(2.Geisterfer-Lowrance': [504], 'A.A.': [505], 'Kass': [506, 1419], 'S.': [507, 671, 2148], 'Tanigawa': [508], 'G.': [509, 551, 989, 1653, 1841, 2037, 3379, 4663], 'Vosberg': [510], 'H.P.': [511], 'McKenna': [512], 'W.': [513, 1839, 2035, 3377, 4661], 'Seidman': [514, 516], 'C.E.': [515], 'J.G.': [517], 'Cell.': [518], '1990;': [519, 996, 1660, 1794], '62:': [520], '999-1006Abstract': [521], 'Full': [522, 964, 1306, 1308, 2183, 2392, 4334, 4401, 4403], 'Text': [523, 965, 1307, 1309, 2184, 2393, 4335, 4402, 4404], 'PDF': [524, 966, 1310, 2185, 2394, 4336, 4405], '(1019)': [527], 'Scholar);': [529], 'further': [530, 2708], 'since': [533], '8': [541], 'genes': [543], 'all': [544], 'which': [546, 794, 820, 1004, 1038, 1045, 1118, 1327, 4649], 'encode': [547], 'sarcomeric': [548], 'proteins': [549, 595, 1973, 3289, 4700], '(3.Bonne': [550], 'Carrier': [552], 'L.': [553], 'Richard': [554], 'P.': [555, 1674], 'Hainque': [556], 'B.': [557, 1247, 1568, 1736, 4384, 4508], 'Schwartz': [558], 'K.': [559, 685, 953, 1837, 1843, 2033, 2039, 2541, 2762, 3375, 3381, 3801, 4659, 4665], 'Circ.': [560, 861, 1369, 1469, 1854, 2050, 3392, 4676], 'Res.': [561, 577, 644, 862, 1370, 1470, 1855, 2051, 3393, 4677], '1998;': [562, 863, 2547, 2768, 3807], '83:': [563, 864], '580-593Crossref': [564], '(300)': [567], 'Scholar,': [569, 856, 940, 1156, 2158, 2172], '4.Redwood': [570], 'C.S.': [571, 638, 942, 1835, 2031, 3373, 4390, 4657], 'Moolman-Smook': [572, 639], 'J.C.': [573, 640, 1165], 'Watkins': [574, 641, 1852, 2048, 3390, 4674], 'H.': [575, 642, 661, 665, 693, 699, 1414, 1845, 1853, 2041, 2049, 3383, 3391, 4667, 4675], 'Cardiovasc.': [576, 643], '1999;': [578, 645, 1371, 1471, 2353], '44:': [579, 646], '20-36Crossref': [580, 647], '(155)': [583, 650], 'Investigations': [586], 'into': [587, 1725, 1977, 3294], 'abnormalities': [590, 1587, 1614], 'suggested': [597, 1697, 3344], 'end': [600], 'stage': [601], 'result': [605, 612, 1611, 3004], 'numerous': [607], 'different': [608, 2851, 3412, 3767], 'effects:': [609], 'diminished': [614, 1403], 'contractility': [615, 633], '(for': [616], 'example,': [617], 'at': [619, 1392, 1995, 2260, 2288, 2312, 2407, 2443, 2453, 2460, 2565, 2692, 2887, 2894, 2991, 3110, 3236, 3420, 4536, 4554, 4562, 4606, 4621, 4629], 'Arg403in': [620], 'β': [621], 'chain),': [624], 'while': [630, 4216], 'others': [631], 'enhance': [632], 'or': [634, 2113, 2270, 2281, 2291, 2436, 2515, 2686, 3055, 3118, 3170, 3353, 3636, 3773, 3849], '(4.Redwood': [637], 'In': [653, 1479, 1617, 2959, 3087], '1997,': [654], 'Kimura': [655], 'et': [656, 1565, 1701, 2536, 2757], 'al.': [657, 1566, 1702, 2537, 2758], '(5.Kimura': [658], 'A.': [659, 687, 1847, 2043, 3385, 3869, 4669], 'Harada': [660], 'Park': [662], 'J.-E.': [663], 'Nishi': [664], 'Satoh': [666], 'M.': [667, 669, 695, 1732], 'Takahashi': [668], 'Hiroi': [670], 'Sasaoka': [672], 'T.': [673, 677, 679, 681, 697, 703, 705, 1927], 'Ohbuchi': [674], 'N.': [675, 986, 1650], 'Nakamura': [676, 692], 'Koyanagi': [678], 'Hwang': [680], 'Choo': [682], 'J.': [683, 894, 931, 958, 1139, 1253, 1300, 1574, 1711, 1734, 1739, 1874, 2177, 2386, 4328, 4395, 4514], 'Chung': [684], 'Hasegawa': [686], 'Nagai': [688], 'R.': [689, 2349, 3950], 'Okazaki': [690], 'O.': [691, 891], 'Matsuzaki': [694], 'Sakamoto': [696], 'Toshima': [698], 'Koga': [700], 'Y.': [701, 1458], 'Imaizumi': [702], 'Sasazuki': [704], 'Nat.': [706], 'Genet.': [707], '1997;': [708, 1256, 1303, 1577, 4398, 4517], '16:': [709], '379-382Crossref': [710], '(464)': [713], 'Scholar)': [715, 1003, 1749, 1863, 1883, 2775], 'were': [716, 740, 1778, 1820, 1884, 1964, 1974, 2086, 2140, 2192, 2234, 2285, 2302, 2424, 2483, 2640, 2690, 2776, 2815, 2846, 2912, 2934, 2948, 3038, 3069, 3181, 3190, 3526, 3608, 3627, 3901, 3926, 4241, 4356], 'report': [720, 1381], '(TNNI3).': [730], 'Five': [731], '(R145G,': [734], 'R145Q,': [735], 'R162W,': [736, 2989], 'G203S,': [737], 'K206Q)': [739], 'along': [742], 'causing': [746], 'deletion': [748], 'one': [750, 1512, 1522, 2619, 3255, 3260], 'codon': [751], '(Lys183).': [752], 'Troponin': [753, 3036, 3660], '(TnI)': [755], 'Ca2+': [769, 1094, 1134, 1601, 2297, 2324, 3072, 3089, 3587, 3643, 3670, 3739, 3913], 'regulation': [770, 1361, 3073, 3588, 3644, 3673, 4547], 'skeletal': [776, 1020, 1196, 1202, 2132, 2240, 2246, 2417, 4307, 4353], 'muscle.': [779], 'protein': [781, 976, 1037, 1048, 1190, 1391, 1929, 1990, 2190, 2492, 3267, 3310, 4226, 4421], 'forms': [782], '1:1:1': [784, 2069, 2122], '(TnC)': [789], '(TnT)': [793], 'binds': [795, 1087], 'thin': [798, 1359, 3211, 3242], 'filament': [799, 1360, 3212, 3243], 'interactions': [801, 839], 'actin': [804, 834, 841, 1288, 2418, 2504], '(TM).': [807], 'binding': [809, 1289, 2521, 2952, 3030, 3197, 3828, 3856, 3880, 3935, 3965, 3991, 4044, 4080, 4281, 4435], 'Ca2+by': [811], 'TnC': [812, 887, 916, 1089, 1126, 1237, 1630, 1865, 1897, 2555, 2615, 2639, 3785, 3817, 3940, 3970, 3995, 4049], 'causes': [813, 1541], 'conformational': [815], 'change': [816, 1530, 1544], 'results': [821, 4415], 'shift': [824], 'position': [827], 'TM': [829], 'respect': [831, 2071], 'helix,': [835], 'allowing': [836], 'strong': [837], 'force-generating': [838], 'between': [840, 1026, 1552, 2318, 3508, 3742, 4221, 4413, 4548, 4593], '(6.Tobacman': [844], 'L.S.': [845], 'Annu.': [846], 'Rev.': [847], 'Physiol.': [848], '1996;': [849], '58:': [850], '447-481Crossref': [851], '(452)': [854], '7.Solaro': [857], 'R.J.': [858, 1297, 4386], 'Rarick': [859], 'H.M.': [860, 1293], '471-480Crossref': [865], '(288)': [868], 'precise': [872], 'structure': [873, 884], 'has': [877, 1015, 1268, 1320, 1335, 1382, 1442, 1625, 3343, 4208], 'yet': [878], 'elucidated,': [881], 'although': [882, 2926, 3756, 4018], 'isolated': [886, 1098], 'known': [889, 1051], '(8.Herzberg': [890], 'James': [892], 'M.N.': [893], 'Mol.': [895, 1254, 1575, 4515], 'Biol.': [896, 959, 1255, 1301, 1576, 1741, 2178, 2352, 2387, 4329, 4396, 4516], '1988;': [897, 4331], '203:': [898], '761-779Crossref': [899], '(290)': [902], 'Low': [905], 'resolution': [906], 'studies': [907, 1200, 4692], 'biochemical': [909], 'data': [910, 1634, 2826, 3490, 4580], 'TnI': [914, 1008, 1203, 1318, 1506, 1510, 1754, 1776, 1819, 2115, 2269, 2435, 2514, 2637, 2663, 2868, 2875, 2897, 2910, 2956, 2971, 2997, 3021, 3033, 3121, 3177, 3288, 3432, 3499, 3663, 3782, 3832, 3860, 3917, 3968, 4047, 4086, 4215, 4270, 4285, 4296, 4309, 4355, 4367, 4447, 4558, 4587, 4618], 'bind': [917], 'strongly': [918], 'form': [920], 'antiparallel': [922], 'dimer': [923], 'multiple': [925], 'interaction': [926, 1235, 1637, 2635, 3780], 'sites': [927], '(9.Olah': [928], 'G.A.': [929], 'Trewhella': [930], 'Biochemistry.': [932, 1148, 2546, 2767, 3806, 3955], '1994;': [933, 961, 1713, 1876, 3956], '33:': [934, 3957], '12800-12806Crossref': [935], '(105)': [938], '10.Farah': [941], 'Miyamoto': [943], 'C.A.': [944], 'Ramos': [945], 'C.H.': [946], 'da': [947], 'Silva': [948], 'A.C.': [949], 'Quaggio': [950], 'R.B.': [951], 'Fujimori': [952], 'Smillie': [954], 'L.B.': [955], 'Reinach': [956, 4391], 'F.C.': [957, 4392], 'Chem.': [960, 1302, 2179, 2388, 4330, 4397], '269:': [962], '5230-5240Abstract': [963], 'encodes': [974], '210': [978], 'amino': [979, 1353, 4343, 4451, 4654], 'acids': [980, 1280, 4655], '(11.Vallins': [981, 1645], 'W.J.': [982, 1646], 'Brand': [983, 1647], 'N.J.': [984, 1648], 'Dabhade': [985, 1649], 'Butler': [987, 1651], 'Browne': [988, 1652], 'Yacoub': [990, 1654], 'M.H.': [991, 1655], 'Barton': [992, 1656, 1675], 'P.J.': [993, 1136, 1657], 'FEBS': [994, 1166, 1658], 'Lett.': [995, 1167, 1659], '270:': [997, 1661], '57-61Crossref': [998, 1662], '(127)': [1001, 1665], 'sole': [1007], 'isoform': [1009, 1441], 'expressed': [1010, 1885, 3291], 'adult': [1012], 'heart.': [1013], 'considerable': [1016], 'homology': [1017], 'isoform,': [1022], 'principal': [1024], 'difference': [1025, 3195, 4042, 4111, 4126, 4168], 'being': [1029], '30-residue': [1031], 'N-terminal': [1032], 'extension': [1033], 'contains': [1039], '2': [1040, 1694, 2309, 2563, 2676, 2734, 2737, 2895, 2992, 3568, 3637], 'serines,': [1041], 'phosphorylation': [1043], 'cAMP-dependent': [1047], 'kinase': [1049], 'regulate': [1053], 'function.': [1055, 4297], 'most': [1057], 'important': [1058], 'sequence': [1060, 1085, 1179, 1755], 'short': [1065], 'central': [1066], 'stretch': [1067], 'residues': [1069, 1182, 1278, 4427, 4470], 'referred': [1070], 'as': [1072, 1096, 1561, 1669, 1888, 1900, 2338, 2627, 2848, 3040, 3473, 3479, 4028, 4163, 4189, 4498], 'region,': [1075], 'required': [1076], 'actin-TM-activated': [1081, 1106, 1594, 2859, 3075, 3138, 3417, 3463, 3590, 4249, 4527], 'ATPase.': [1083], 'peptide': [1099, 4311, 4418, 4467], 'capable': [1101], 'skinned': [1113], 'fibers,': [1115], 'can': [1119], 'relieved': [1121], 'addition': [1124, 2363, 3093, 3113], 'activating': [1131, 2280, 3088], 'concentrations': [1132, 1959, 2191, 3213, 3842], '(12.Cachia': [1135], 'Van': [1137, 1248, 1366, 1421, 1569, 4509], 'Eyk': [1138, 1158, 1249, 1367, 1422, 1570, 4324, 4379, 4510], 'Ingraham': [1140], 'R.H.': [1141], 'McCubbin': [1142], 'W.D.': [1143], 'Kay': [1144], 'C.M.': [1145], 'Hodges': [1146, 1162, 1251, 1572, 4326, 4393, 4512], 'R.S.': [1147, 1163, 1252, 1573, 4327, 4394, 4513], '1986;': [1149], '25:': [1150], '3553-3562Crossref': [1151], '(52)': [1154], '13.Van': [1157], 'J.E.': [1159, 1250, 1368, 1423, 1571, 4325, 4380, 4511], 'Strauss': [1160], 'J.D.': [1161, 2160], 'Ruegg': [1164], '1993;': [1168], '323:': [1169], '223-228Crossref': [1170], '(31)': [1173], 'minimum': [1177, 1227], 'consists': [1180], '137': [1183], '148': [1185], '(104': [1191], '115': [1193], 'rabbit': [1195, 2130, 2137, 2239, 2245, 2251, 2416, 2422, 4352], 'TnI).': [1198], 'Further': [1199, 3208], 'peptides': [1204], 'revealed': [1206, 4534], '"second': [1208, 1243], 'actin-TM-binding': [1209, 1559], 'site"': [1210], '(161': [1211], '181': [1213, 4473], 'cTnI),': [1216], 'necessary': [1217], 'enhanced': [1219], 'compared': [1221, 3159, 3609, 4564], 'achieved': [1224], 'sequence,': [1228], 'region': [1231, 1536, 4349, 4431, 4458], 'critical': [1232], '(149': [1238], '164,': [1240], 'putative': [1242], 'TnC-binding': [1244, 1555], 'site")': [1245], '(14.Tripet': [1246, 1567, 4507], '271:': [1257, 1578, 4518], '728-750Crossref': [1258, 1579, 4519], '(184)': [1261, 1582, 4522], 'Analysis': [1264], 'truncation': [1266], 'mutants': [1267, 2911, 2974, 4204, 4240, 4263, 4377], 'case': [1273], 'cTnI,': [1275], 'additional': [1276], 'C-terminal': [1277, 1351, 4652], '(amino': [1279], '187–198': [1281], 'sequence)': [1286], 'influence': [1287, 4425], '(15.Rarick': [1292], 'Tu': [1294], 'X.-H.': [1295], 'Solaro': [1296], 'Martin': [1298], 'A.F.': [1299], '272:': [1304, 4399], '26887-26892Abstract': [1305], '(95)': [1313], 'Perturbation': [1316], 'function': [1319, 1502, 3330, 4695], 'linked': [1322], 'myocardial': [1324], 'stunning': [1325], 'reversible': [1328], 'dysfunction': [1330], 'takes': [1331], 'place.': [1332], 'phenomenon': [1334], 'caused': [1340, 2878, 3027, 3100, 3192, 4312], 'proteolysis': [1342], 'TnI,': [1344, 1399, 4255], 'initially': [1345], 'producing': [1346], 'fragment': [1348], 'missing': [1349], '17': [1352], 'acids,': [1354], 'concomitant': [1356], 'alteration': [1357], '(16.McDonough': [1362], 'J.L.': [1363, 1418], 'Arrell': [1364], 'D.K.': [1365], '84:': [1372, 1472], '9-20Crossref': [1373], '(281)': [1376], 'A': [1379, 3853, 4037], 'transgenic': [1385], 'mice': [1386], 'expressing': [1387], '1–193': [1389], 'truncated': [1390], '9–17%': [1393], 'level': [1396], 'endogenous': [1398], 'developed': [1400], 'dilatation,': [1402], 'contractility,': [1405], 'myofilament': [1408], 'responsiveness': [1410], '(17.Murphy': [1411], 'A.M.': [1412], 'Kogler': [1413], 'Georgakopoulos': [1415], 'D.': [1416, 2345], 'McDonough': [1417], 'D.A.': [1420], 'Marban': [1424], 'E.': [1425, 1705, 1868, 2174, 2385], 'Science.': [1426], '2000;': [1427, 1856, 2052, 3394, 4678], '287:': [1428], '488-491Crossref': [1429], '(214)': [1432], 'vital': [1436], 'importance': [1437], 'emphasized': [1445], 'severe': [1448], 'knockout': [1453], 'mouse': [1454], '(18.Huang': [1455], 'X.': [1456], 'Pi': [1457], 'Lee': [1459], 'K.J.': [1460], 'Henkel': [1461], 'A.S.': [1462], 'Gregg': [1463], 'R.G.': [1464], 'Powers': [1465], 'P.A.': [1466], 'Walker': [1467], 'J.W.': [1468, 1791], '1-8Crossref': [1473], '(116)': [1476], 'order': [1480], 'understand': [1482], 'how': [1483], 'subtle': [1484], 'alterations': [1485], 'disease,': [1490], 'we': [1491, 2966, 3403, 4638], 'used': [1493, 2102, 2754, 2838, 3182], 'compare': [1499, 2840], 'thein': [1500], 'vitro': [1501, 3340, 4198, 4691], 'mutants,': [1511], 'containing': [1513, 1810, 1937, 2256, 3116, 3351, 3411, 3434, 3500, 3661, 3725, 3845, 4616, 4642], 'R145G': [1515, 1520, 1770, 2907, 2987, 3117, 3165, 3431, 3662, 3688, 3967, 4237, 4302, 4557, 4617], 'mutation,': [1516], 'R162W.': [1519], 'residue': [1531, 1547], 'Arg145': [1532], 'charge': [1543], 'located': [1548], 'overlap': [1551], 'second': [1554, 1558, 2646], 'site': [1556, 1560], 'defined': [1562, 2847], 'Tripet': [1564, 4383], 'revealed,': [1588], 'namely': [1589], 'ability': [1591], 'inhibit': [1593], 'increase': [1599, 3102, 3454], 'regulation,': [1605], 'vivo.': [1616], 'addition,': [1618], 'finding': [1620], 'supports': [1631], 'concerning': [1635], 'proteins.': [1641], 'Human': [1642, 1831], 'cDNA': [1644], 'Scholar),': [1667, 1801], 'obtained': [1668, 1899, 3491, 3628, 3906, 3931, 4416, 4585], 'gift': [1671, 1902], 'from': [1672, 1822, 1903, 2091, 2129, 2136, 2653, 3361, 3435, 3445, 3458, 3485, 3620, 3768, 3979, 4112, 4127, 4169], 'Dr.': [1673], '(Imperial': [1676], 'College,': [1677], 'London,': [1678], 'United': [1679], 'Kingdom),': [1680], 'amplified': [1682], 'polymerase': [1684, 1761], 'reaction': [1686, 2358], 'introduce': [1688], 'silent': [1690], 'codons': [1693], '4': [1696, 2566, 3471], 'al': [1699], 'Hillawi': [1700, 1704, 1867], '(19.al': [1703, 1866], 'Minchin': [1706, 1869], 'S.D.': [1707, 1870], 'Trayer': [1708, 1871, 1906], 'I.P.': [1709, 1872], 'Eur.': [1710, 1873], 'Biochem.': [1712, 1875, 2220], '225:': [1714, 1877], '1195-1201Crossref': [1715, 1878], '(32)': [1718, 1881], 'product': [1722], 'cloned': [1724], 'bacterial': [1727], 'expression': [1728], 'vector': [1729], 'pMW172': [1730], '(20.Way': [1731], 'Gooch': [1733], 'Pope': [1735], 'Weeds': [1737], 'A.G.': [1738], 'Cell': [1740, 2351], '1989;': [1742], '109:': [1743], '593-605Crossref': [1744], '(168)': [1747], 'usingNdeI': [1750], 'HindIII.': [1752], 'altered': [1757], 'two-step': [1760], 'reaction-based': [1763], 'oligonucleotide-directed': [1764], 'mutagenesis': [1765], 'protocol': [1766, 1970, 2608], 'produce': [1768], 'mutations.': [1774], 'constructs': [1777], 'overexpressed': [1779], 'inEscherichia': [1780], 'coli': [1781], 'strain': [1782], 'BL21(DE3)pLysS': [1783], '(21.Studier': [1784], 'F.W.': [1785, 2545, 2766, 3805], 'Rosenberg': [1786], 'A.H.': [1787], 'Dunn': [1788], 'J.J.': [1789], 'Dubendorff': [1790], 'Methods': [1792, 2149, 2163, 2350], 'Enzymol.': [1793, 2150, 2164], '185:': [1795], '60-89Crossref': [1796], '(5981)': [1799], 'cells': [1804], 'lysed': [1805], 'after': [1806], 'freeze-thawing': [1807], 'buffer': [1809, 1936, 2255, 2428, 3844], '5': [1811, 1978, 2672, 3985, 4032], 'm': [1812, 1952, 1956, 2596, 2728], 'urea.': [1813], 'extract': [1824], 'cationic': [1826], 'exchange': [1827], 'hydroxyapatite': [1829], 'chromatography.': [1830], 'TnT': [1833, 3334, 4646], '(22.Redwood': [1834, 2030, 3372, 4656], 'Lohmann': [1836, 2032, 3374, 4658], 'Bing': [1838, 2034, 3376, 4660], 'Esposito': [1840, 2036, 3378, 4662], 'Elliott': [1842, 2038, 3380, 4664], 'Abdulrazzak': [1844, 2040, 3382, 4666], 'Knott': [1846, 2042, 3384, 4668], 'Purcell': [1848, 2044, 3386, 4670], 'I.': [1849, 1905, 2045, 3387, 4671], 'Marston': [1850, 2046, 3388, 4672], 'S.B.': [1851, 2047, 3389, 4673], '86:': [1857, 2053, 3395, 4679], '1146-1152Crossref': [1858, 2054, 3396, 4680], '(66)': [1861, 2057, 3399, 4408, 4683], 'described': [1889, 3041], 'previously.': [1890], 'pET11c': [1892], 'construct': [1893], 'encoding': [1894], 'Prof.': [1904], '(Birmingham,': [1907], 'UK).': [1908], 'Recombinant': [1909], 'mixing': [1916], '1.5:1:1': [1918], 'molar': [1919, 2571], 'ratio': [1920], 'troponins': [1923], 'C,': [1924], 'I,': [1925], 'diluted': [1931], '0.75': [1933], 'mg/ml': [1934], '10': [1938, 2000, 2009, 2458, 2730], 'mm': [1939, 1944, 1983, 2258, 2330, 2591, 2600, 2666, 2673, 2677, 2684, 2688, 2721, 2731, 2738, 3851, 3863, 3998, 4052], 'imidazole,': [1940], 'pH': [1941, 1980, 2593, 2668, 2723], '7.0,': [1942, 1981, 2594], 'DTT,': [1945], '0.01%': [1946], 'sodium': [1947], 'azide,': [1948], '50': [1949, 3486], 'μmCaCl2,': [1950], '6': [1951, 2725], 'urea,': [1953], 'KCl.': [1957], 'urea': [1961], 'KCl': [1963], 'stepwise': [1968], 'dialysis': [1969, 2588], 'finally': [1975], 'dialyzed': [1976], 'mmPIPES,': [1979], '3.87': [1982], 'MgCl2,': [1984, 2674], 'mmDTT': [1986], '("ATPase': [1987], 'buffer").': [1988], 'Aggregated': [1989], 'removed': [1992, 2585], 'centrifugation': [1994, 2477], '12,300': [1996], '×': [1997, 2455, 3919, 3923, 3942, 3946], 'g': [1998, 2456], 'min': [2001, 2459], 'concentrated': [2006], 'Centricon': [2008], 'concentrators.': [2010], 'composition': [2012], 'determined': [2019, 2193, 2339, 2605, 3066], 'SDS-PAGE,': [2021], 'followed': [2022], 'Coomassie': [2024, 2496], 'Blue': [2025], 'staining': [2026], 'scanning': [2028], 'densitometry': [2029], 'Wild': [2060], 'close': [2067], 'three': [2074, 2409], 'subunits': [2075], '(TnT:TnI:TnC': [2076], '1:0.95:1.12': [2078], '(n': [2079], '=': [2080, 3675, 3699, 3714, 3752], '3))': [2081], 'indistinguishable': [2090, 3126, 3978], 'type.': [2093], 'Although': [2094], 'not': [2095, 3026, 3191, 3441, 3542, 3584, 3634, 3765, 4040, 4276, 4460], 'routinely': [2096], 'used,': [2097], 'filtration': [2099], 'chromatography': [2100], 'show': [2104, 3184], 'reconstitution': [2107], 'method': [2108, 2377, 2533], 'either': [2110, 2682, 3052, 3630, 3769, 3846], 'resulted': [2116], 'single': [2119, 4342, 4450], 'species': [2120], '(the': [2121], 'complex).': [2123], 'Myosin': [2124], 'subfragment-1': [2125], '(S-1)': [2126], 'F-actin': [2128], 'fast': [2131], 'α-TM': [2135, 2252, 2423], 'prepared': [2141], 'standard': [2143, 2196], 'methods': [2144], '(23.Margossian': [2145], 'Lowey': [2147], '1982;': [2151, 2165], '85:': [2152, 2166], '55-71Crossref': [2153], '(809)': [2156], '24.Pardee': [2159], 'Spudich': [2161], 'J.A.': [2162], '164-181Crossref': [2167], '(959)': [2170], '25.Eisenberg': [2173], 'Kielley': [2175], 'W.W.': [2176], '1974;': [2180], '249:': [2181], '4742-4748Abstract': [2182], 'All': [2189], 'colorimetric': [2197], 'assay': [2198, 2399, 2529, 3024, 3342, 3797, 3936], '(26.Smith': [2199], 'P.K.': [2200], 'Krohn': [2201], 'R.I.': [2202], 'Hermanson': [2203], 'G.T.': [2204], 'Mallia': [2205], 'A.K.': [2206], 'Gartner': [2207], 'F.H.': [2208], 'Provenzano': [2209], 'M.D.': [2210], 'Fujimoto': [2211], 'E.K.': [2212], 'Goeke': [2213], 'N.M.': [2214], 'Olson': [2215], 'Klenk': [2217], 'D.C.': [2218], 'Anal.': [2219], '1985;': [2221], '150:': [2222], '76-85Crossref': [2223], '(18349)': [2226], 'Actin-TM-activated': [2229], 'S-1': [2231], 'rates': [2233], 'measured': [2235, 2374, 3837, 4116, 4131, 4173], '0.5': [2237], 'μm': [2238, 2244, 2250, 2268, 2310, 2415, 2421, 2434, 2438, 2896, 3532, 3632], 'S-1,': [2242], '7': [2243, 2414], 'actin,': [2247], '3': [2257], 'ATP': [2259], '37': [2261, 2888, 3111], '°C': [2262, 2445, 2462, 2567, 2889], '0–4': [2267], '0–2': [2271, 2433, 2437], 'μmtroponin': [2272], 'complex.': [2273, 3296, 3555], 'For': [2274, 2293], 'titration': [2276, 3578], 'conditions,': [2283, 3146], 'carried': [2286, 2303, 2401, 3528], 'out': [2287, 2304, 2402, 3529], 'pCa': [2289, 2316, 3131, 3237, 3421, 3619, 4537, 4555, 4622, 4630], '4.5': [2290, 2319, 3621, 4538, 4623], '8.5.': [2292, 2321, 3623, 4556], 'study': [2295, 3363, 4194, 4502], 'dependence': [2298], 'values': [2317, 2854, 3626, 3905], 'free': [2323], 'concentration': [2325, 2335, 3613], 'set': [2327, 3854], 'EGTA': [2331, 4053], 'appropriate': [2334], 'CaCl2': [2337, 2685, 3864, 3999], 'WINMAXC': [2342], 'program': [2343], '(27.Bers': [2344], 'Patton': [2346], 'C.': [2347], 'Nutticelli': [2348], '40:': [2354], '1-94Google': [2355], 'stopped': [2360], '5%': [2365], 'trichloroacetic': [2366], 'amount': [2370], 'phosphate': [2372], 'released': [2373], 'Taussky': [2379], 'Schorr': [2381, 2384], '(28.Taussky': [2382], 'H.H.': [2383], '1953;': [2389], '202:': [2390], '675-685Abstract': [2391], 'Each': [2398], 'triplicate': [2404], 'least': [2408], 'separate': [2410], 'preparations': [2411, 3371], 'TnI.': [2413, 3057, 3727], 'mixed': [2425], 'incubated': [2442], '25': [2444, 2461], '15': [2447], 'min.': [2448], 'centrifuged': [2452], '313,000': [2454], '(Beckman': [2463], 'TLA-100': [2464], 'rotor)': [2465], 'pellet': [2467, 2482, 2509], 'actin-TM': [2469, 3206, 3566], 'filaments.': [2470], 'Samples': [2471], 'prior': [2475], 'supernatant': [2480], 'SDS-PAGE': [2486, 3068], '15%': [2489], 'gel;': [2491], 'stained': [2494], 'Blue.': [2497], 'Under': [2498, 3556], 'conditions': [2500, 2965, 3090, 3558, 3973, 4120, 4135, 4177], '>95%': [2501, 2994, 3559], '<10%': [2511], 'sedimented': [2518], 'alone.': [2519], 'TnI-TnC': [2520], 'investigated': [2523, 3405], 'BIAcore-X': [2526], 'based': [2530, 3796], 'Reiffert': [2535, 2756], '(29.Reiffert': [2538, 2759, 3798], 'S.U.': [2539, 2760, 3799], 'Jacquet': [2540, 2761, 3800], 'Heilmeyer': [2542, 2763, 3802], 'L.M.G.': [2543, 2764, 3803], 'Herberg': [2544, 2765, 3804], '37:': [2548, 2769, 3808], '13516-13525Crossref': [2549, 2770, 3809], '(47)': [2552, 2773, 3812], 'labeled': [2557, 3939], 'biotin': [2559, 2583], 'incubation': [2561], 'h': [2564], '3-fold': [2570], 'excess': [2572], '6-(biotinamidocaproylamido)-caproic': [2574], 'acidN-hydroxy-succinimide': [2575], 'ester': [2576], '(Sigma)': [2577], '20': [2579, 2590, 2665, 2720], 'mmNaHCO3.': [2580], 'Excess': [2581], 'uncomplexed': [2582], 'extensive': [2587], 'against': [2589], 'MOPS,': [2592, 2667, 2722], '0.3': [2595], 'KCl,': [2597, 2671, 2729], 'DTT.': [2601, 2739], 'Biotin': [2602], 'incorporation': [2603], 'supplied': [2609], 'HABA/Avidin': [2611], 'reagent': [2612], '(Sigma).': [2613], 'Biotinylated': [2614], 'coupled': [2617], 'flow': [2620, 2647, 2694], 'cell': [2621, 2648, 2656], 'BIAcore': [2624, 3824], 'SA': [2625, 3825], 'chip': [2626, 2712], 'previously': [2628, 4462], 'detailed': [2629], 'sensorgrams': [2631], 'showing': [2632], 'generated': [2641], 'subtraction': [2643], 'response': [2649, 3425], '(lacking': [2650], 'captured': [2651], 'TnC)': [2652], 'test': [2655], 'response.': [2657], '100-s': [2658], 'injections': [2659, 2718], '25–500': [2661], 'nm': [2662], '8.0,': [2669, 2724], '0.5m': [2670], 'DTT': [2678], '("Binding': [2679], 'buffer"),': [2680], '0.1': [2683, 3847, 3862, 3997], 'EGTA,': [2689], 'made': [2691], 'rate': [2695, 2784, 2791, 2886, 3109, 3457, 3892, 4017, 4070], '30': [2697], 'μl/min.': [2698], 'dissociation': [2700, 2747, 2783, 3876, 3889, 4016, 4068], 'phase': [2701], 'allowed': [2703], 'proceed': [2705], '100': [2709], 's.': [2710], 'surface': [2713, 3793], 'regenerated': [2715], '60-s': [2717], 'murea,': [2726], 'EDTA,': [2732], 'mmEGTA': [2735], 'Using': [2740], 'BIAEvaluation': [2742], 'software,': [2743], 'portions': [2744], 'association': [2749, 2790, 2800, 3874, 3885, 3896, 4065, 4074], 'phases': [2750, 3877], 'equivalent': [2751, 4299, 4468, 4483], 'derive': [2779], 'estimates': [2780, 3882], 'constant': [2785, 2792, 2802, 3612, 3898, 4076], '(k': [2786, 2793, 3886, 3890], 'd)': [2787, 3891], 'a)': [2794, 2804, 3887, 3900], 'assuming': [2795], 'simple': [2796], '1:1': [2797], 'kinetics.': [2798], 'equilibrium': [2801, 3897, 4075], '(K': [2803, 2808, 3899, 4006, 4056], 'then': [2806], 'calculated': [2807, 4064], '=k': [2810], 'a/k': [2811], 'd).': [2812], 'Data': [2813, 4186], 'sets': [2814], 'give': [2818, 3125, 4360], 'mean': [2819, 4164, 4190], '±': [2820, 3658, 3677, 3701, 3716, 3754, 4094, 4096, 4098, 4100, 4102, 4104, 4106, 4108, 4123, 4143, 4145, 4147, 4149, 4151, 4153, 4155, 4157, 4159, 4165, 4191], 'S.E.': [2821, 4192], 'Statistical': [2822], 'analysis': [2823, 3327, 3758, 3871], 'performed': [2828, 2962], 'GraphPad': [2831], 'InStat': [2832], 'software.': [2833], 'Newman-Keuls': [2835], 'post-test': [2836], 'pairs': [2841], 'group': [2843], 'means.': [2844], 'Values': [2845], 'statistically': [2849], 'significantly': [2850, 3766, 4004], 'p': [2853], '<0.05.': [2855], 'compared.': [2870, 3086], 'Addition': [2871], 'myosin-actin-α-TM': [2877, 3099], 'decrease': [2880, 4317], '70%': [2882], 'saturation': [2891, 4563], 'EC50': [2900, 2917, 4258], '0.8': [2904], 'μm.': [2905], 'less': [2913, 3354, 3504, 4245], 'effective': [2914], 'inhibitors,': [2915], '1.4': [2921], '1.5': [2923], 'μm,': [2924, 2993], 'respectively,': [2925], 'saturating': [2928], 'levels': [2929, 4609], '(Fig.1': [2939], 'A).': [2940, 3129, 3174, 4273], 'whether': [2943], 'differences': [2945, 3009, 3187, 4220, 4545, 4592], 'due': [2949, 3543, 4011], 'actin-TM.': [2958, 3035], 'sedimentation': [2960, 3179], 'bound': [2975, 3564, 3821], 'tightly': [2976], 'actin-TM;': [2978], 'Fig.': [2979], 'B': [2981, 3986], 'type,': [2986, 3604], 'each': [2990, 3063, 3834], 'pellet.': [3002], 'large': [3008], 'potency': [3012, 4320, 4365, 4495], 'are': [3025, 3290, 3298, 4161, 4187, 4598, 4604, 4632], 'weaker': [3029, 4280], 'isoforms': [3047], 'TnC,': [3049], 'TnT,': [3050], 'final': [3059], 'subunit': [3060], 'compositions': [3061], 'identical.': [3070], '(pCa': [3091], '4.5)': [3092], 'over': [3104, 3838], '100%': [3105, 3365, 3368, 3438, 3745, 3749, 3770, 3774], '°C;': [3112], 'activation': [3127, 4535, 4620], '(Fig.2': [3128, 3173], 'At': [3130], '8.5,': [3132], 'inhibited': [3136, 4574], '60%;': [3142], 'however,': [3143], 'it': [3147, 3315], 'only': [3156], '25%': [3157, 4576], 'little': [3169], 'no': [3171, 3299], 'As': [3175], 'alone,': [3178], '(Fig.2IB).': [3207], '2-fold': [3214, 3219], 'lower': [3215], '(3.5': [3216], 'μm)': [3217, 3222], 'higher': [3220], '(14': [3221], 'confirmed': [3223], 'percentage': [3226], '8.5': [3238, 3422], 'independent': [3240], 'concentration.': [3244], 'individuals': [3253], 'copy': [3258, 3262], 'particular': [3265], 'contractile': [3266, 4699], 'gene.': [3268], 'It': [3269], 'likely': [3271], 'hearts': [3275], 'carrying': [3278], 'incorporated': [3293], 'There': [3297], 'reports': [3300], 'determination': [3303], 'vivoproportion': [3307], 'but': [3314, 4039, 4543], 'unlikely': [3317], '50%': [3322, 3352, 3448, 3602, 3605], 'total.': [3325], 'Recent': [3326], 'motility': [3341], 'behavior': [3347], 'cannot': [3357], 'necessarily': [3358], 'predicted': [3360], 'Thus': [3402], 'effect': [3407, 4291], 'type:mutant': [3414], 'ratios': [3415], '(Fig.3).': [3423], 'increasing': [3427], 'proportion': [3429, 3481, 3511], '0': [3436, 3446], 'clearly': [3440, 3581], 'linear:': [3442], 'transition': [3444], 'accompanied': [3451], '38': [3459], '51%': [3461], 'whereas': [3465, 4570], 'rose': [3468, 3484], 'almost': [3470], 'times': [3472], 'much': [3474, 4314], '(from': [3475], '51': [3476], '102%)': [3478], '100%.': [3488], 'clear': [3505], 'biphasic': [3506, 3571], 'relationship': [3507, 3540, 3572], 'could': [3516], 'adequately': [3519], 'fitted': [3520], 'straight': [3523], 'line.': [3524], 'Experiments': [3525], 'total': [3533, 3640], 'ensure': [3536], 'nonlinear': [3539], 'displacement': [3546], '(Fig.': [3567, 3984, 4031, 4271, 4577], 'B).': [3569], 'still': [3580], '(data': [3583, 3633], 'shown).': [3585], 'troponin,': [3596, 3598], 'buffers': [3617], 'Indistinguishable': [3624], 'ΔpCa50': [3625, 3698], 'shown)': [3635], 'μm(Fig.': [3638], '4)': [3639], 'troponin.': [3641], 'pCa50': [3655], '6.26': [3657], '0.03.': [3659], 'greatly': [3668], '(ΔpCa50': [3674, 3713, 3751], '+0.56': [3676], '0.03;p': [3678, 3717], '<': [3679, 3718], '0.001);': [3680], '+0.17': [3700], '0.03': [3702], '(p<': [3703, 4121, 4136, 4178], '0.001).': [3704], 'An': [3705], 'smaller': [3711], 'magnitude': [3712], '+0.13': [3715], '0.05)': [3719], 'Again,': [3728], 'lying': [3741], '+0.08': [3753], '0.04),': [3755], 'statistical': [3757], '(p': [3776], '>': [3777], '0.05).': [3778], 'immobilized': [3784], 'real': [3789], 'time': [3790], 'resonance': [3795], 'Purified': [3815], 'biotinylated': [3819], 'chip.': [3826], 'mmCaCl2': [3848], 'EGTA.': [3852], 'curves': [3857], 'Fig.5': [3868], 'By': [3870], 'curves,': [3881], 'constants': [3893, 4071], 'obtained.': [3902], 'TheK': [3903], 'absence': [3911], '(1.61': [3918], '108m−1': [3920, 3943], '7.34': [3922], '107m−1,': [3924, 3947], 'respectively)': [3925, 3948], 'very': [3927, 4633], 'solution': [3934], 'fluorescently': [3938], '(1.27': [3941], '4.17': [3945], '(30.Liao': [3949], 'Wang': [3951], 'C.K.': [3952], 'Cheung': [3953], 'H.C.': [3954], '12729-12734Crossref': [3958], '(58)': [3961], 'TableI).': [3988], 'However,': [3989, 4340, 4464], 'stronger': [4005], '2.6': [4009], 'times)': [4010, 4060], 'markedly': [4014], 'slower': [4015], 'k': [4020], 'same': [4027, 4119, 4134, 4176], 'Table': [4035], 'I).': [4036], 'small,': [4038], 'significant,': [4041], '1.3': [4059], '(Table': [4061], 'I).Table': [4062], 'IThe': [4063], '(ka)': [4066], '(kd)': [4069], '(Ka)': [4077], 'TnCTroponin': [4088], 'ICa2+k': [4089], 'a/105m−1s−1k': [4090, 4139], 'd/10−3s−1K': [4091, 4140], 'a/108m−1nWild': [4092, 4141], 'type4.033': [4093], '0.6162.494': [4095], '0.2651.611': [4097], '0.1506R145G4.124': [4099], '0.7332.618': [4101], '0.5871.53': [4103], '0.2023R162W3.397': [4105], '0.6250.833': [4107], '0.203': [4109], 'aSignificant': [4110, 4125], 'value': [4115, 4130, 4172], '0.01).4.157': [4122], '0.815': [4124], '0.01).4Troponin': [4137], 'IMg2+k': [4138], 'type3.728': [4142], '0.5405.087': [4144], '0.2970.734': [4146], '0.0974R145G4.222': [4148], '0.3875.346': [4150], '0.5010.814': [4152], '0.1063R162W3.523': [4154], '0.3203.783': [4156], '0.3890.945': [4158], '0.0763Data': [4160], 'S.E.a': [4166], 'Significant': [4167], '0.01).': [4179], 'Open': [4180], 'table': [4181], 'new': [4184], 'tab': [4185], 'properties': [4199, 4443, 4637], 'yielded': [4209], 'information': [4210], 'structure-function': [4213], 'revealing': [4218], 'underlie': [4229], 'pathogenesis': [4231], 'disease.': [4234], 'potent': [4246], 'inhibitors': [4247], 'approximately': [4264], 'double': [4265], 'consequence': [4278], 'hence': [4287], 'primary': [4290], '12-mer': [4306], 'profound': [4316, 4601], '(31.Van': [4323], '263:': [4332], '1726-1732Abstract': [4333], 'substitutions': [4345], 'within': [4346], 'full-length': [4351, 4420, 4446], 'reductions': [4362], 'here': [4372], '(32.Van': [4378], 'Thomas': [4381], 'L.T.': [4382], 'Wiesner': [4385], 'Pearlstone': [4387], 'J.R.': [4388], 'Farah': [4389], '10529-10537Abstract': [4400], 'discrepancy': [4412], 'probably': [4422], 'reflects': [4423], 'outside': [4428, 4454], 'stabilizing': [4433], 'minimal': [4438], 'sequence.': [4440], 'Decreased': [4441], 'substitution': [4453], 'reported.': [4463], '129': [4471], 'protein,': [4477], 'triple': [4479], 'Lys174,': [4485], 'Lys177,': [4486], 'Lys178': [4488], 'Ala': [4490], 'produced': [4491], 'Titration': [4525], 'activity': [4530], 'whole': [4532], 'significant': [4544], '0%': [4560], '60%': [4566], '2).': [4578], 'These': [4579], 'contrast': [4581], 'considerably': [4599], 'they': [4603], 'saturated': [4608], 'inhibition.': [4611], 'characteristics': [4613], '(normal': [4619], 'lack': [4626], '8.5)': [4631], 'find': [4639], 'lacks': [4650], '28': [4653], 'great': [4687], 'majority': [4688]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2068251811', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-13T16:10:22.892011', 'created_date': '2016-06-24'}