Publication Information

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3815, 4211], 'involvement': [31, 283], 'both': [33, 118, 164, 285, 370, 416, 2923, 4186, 4238], 'secretory': [35, 287, 3725, 3987, 4188], 'endocytic': [37, 289, 1200], 'pathways': [38, 290], 'Aβ': [40, 170, 207, 292, 422, 459, 599, 728, 1097, 1187, 1237, 1264, 1348, 1420, 1633, 1672, 1725, 2128, 2281, 2334, 2419, 2427, 2542, 3164], 'generation.': [41, 293], 'Here,': [42, 294, 1485], 'we': [43, 295, 1486, 1590, 3517, 3524, 3550, 3598, 3615, 3660, 3770, 3989, 4013, 4036, 4244, 4265, 4394], 'used': [44, 296, 524, 1963, 1978, 2811], 'HeLa': [45, 297, 1746, 2578, 2820, 2933, 3002, 3170, 3607], 'cells': [46, 298, 1006, 1180, 1228, 1384, 1858, 2482, 2496, 2579, 2592, 2821, 2877, 2934, 3003, 3244, 3268, 4031, 4102], 'stably': [47, 299, 3173, 3610], 'expressing': [48, 300, 1749, 3611], 'tetracycline-regulated': [50, 302, 1587], 'dominant-negative': [51, 303, 1477, 1499, 1751, 3177, 3200, 3397, 3691, 3865, 4311], 'dynamin': [52, 304, 686, 1502, 1752, 2294, 3178, 3201, 3398, 3502, 3603, 3632, 3673, 3866, 3972, 4375], 'I': [53, 305, 1503, 1753, 3149], '(dyn': [54, 306], 'K44A),': [55, 307], 'selectively': [57, 309, 3874], 'inhibits': [58, 310, 1526, 3204], 'receptor-mediated': [59, 311, 1539, 3158, 3205, 3449, 3929], 'endocytosis,': [60, 312], 'analyzed': [62, 314, 1952, 2792], 'effects': [64, 316, 1491, 3231, 3252, 3683, 3970], 'on': [65, 90, 155, 317, 342, 407, 612, 1036, 1225, 1470, 1492, 1605, 1686, 2552, 2577, 2786, 3114, 3235, 3256, 3364, 3637, 3743, 3782, 3974], 'processing': [67, 147, 162, 243, 319, 399, 414, 495, 981, 1068, 1494, 1615, 1704, 3937, 3978], 'endogenous': [69, 169, 206, 321, 421, 458, 4044, 4401], 'APP.': [70, 322, 4212], 'Upon': [71, 323], 'induction': [72, 324, 1593, 2295, 2585, 3338, 3452, 3788, 4248], 'dyn': [74, 103, 176, 326, 355, 428, 1595, 1810, 1985, 3180, 3233, 3254, 3340, 3380, 3454, 3467, 3582, 3685, 3713, 3790, 3897, 4026, 4142, 4226, 4250, 4278, 4404], 'K44A,': [75, 104, 177, 327, 356, 429, 3181], 'levels': [76, 328, 1659, 2208, 3474, 3485, 3553, 3573, 3621, 3890, 4113, 4136, 4218, 4231, 4255, 4369, 4409], 'mature': [78, 330, 3527, 3675, 3701, 3869, 3881, 4043, 4111, 4127, 4233], 'APP': [79, 89, 99, 154, 223, 331, 341, 351, 406, 475, 532, 619, 679, 719, 736, 983, 1065, 1090, 1176, 1203, 1331, 1471, 1493, 1604, 1622, 1644, 1684, 1967, 1982, 1996, 2077, 2186, 2223, 2568, 3126, 3166, 3480, 3490, 3528, 3537, 3624, 3676, 3717, 3742, 3753, 3765, 3816, 3841, 3872, 3882, 3960, 3975, 4020, 4050, 4087, 4112, 4128, 4135, 4148, 4156], 'rose': [80, 332], 'at': [81, 212, 248, 333, 464, 500, 575, 1012, 1069, 1646, 1709, 1733, 1853, 1864, 1935, 2194, 2314, 2674, 2696, 2700, 2853, 2868, 2880, 2909, 2959, 3020, 3063, 3276, 3307, 3766, 4058, 4089, 4129], 'cell': [83, 250, 335, 502, 597, 625, 760, 807, 1014, 1039, 1073, 1335, 1450, 1711, 1742, 1747, 3171, 3418, 3507, 3608, 3732, 3819, 4097, 4131], 'surface,': [84, 336, 4132], 'consistent': [85, 233, 337, 485, 1195, 1693, 3410, 3711, 4091, 4122], 'with': [86, 234, 338, 486, 615, 966, 1196, 1344, 1626, 1694, 1847, 1990, 1999, 2011, 2024, 2043, 2083, 2087, 2118, 2131, 2138, 2158, 2166, 2176, 2253, 2278, 2387, 2395, 2430, 2461, 2477, 2487, 2502, 2513, 2538, 2545, 2601, 2616, 2630, 2689, 2776, 2780, 2843, 2861, 2878, 2890, 2908, 2946, 2951, 2965, 3008, 3023, 3036, 3047, 3068, 3095, 3132, 3136, 3175, 3314, 3411, 3712, 3774, 3796, 3807, 3836, 3848, 3880, 3998, 4073, 4092, 4103, 4123, 4139, 4282, 4362, 4386, 4415], 'retention': [87, 152, 339, 404, 1600, 3360, 3763, 3922], 'plasma': [92, 157, 214, 344, 409, 466, 1607, 1648, 1688, 1735, 3305, 3366, 3768, 3913, 4192, 4334], 'membrane.': [93, 345, 1689, 3367], 'The': [94, 120, 129, 346, 372, 381, 1637, 1829, 2062, 2564, 3251, 3828, 3889, 3910, 4230], 'α-secretase': [95, 347, 1661, 4197, 4341], 'cleavage': [96, 122, 348, 374, 717, 749], 'products': [97, 143, 349, 395, 2190], 'were': [100, 352, 1775, 1804, 1862, 1902, 1921, 1951, 1962, 1977, 2040, 2116, 2156, 2174, 2191, 2209, 2226, 2260, 2284, 2307, 2393, 2421, 2454, 2483, 2497, 2508, 2527, 2536, 2543, 2550, 2593, 2612, 2652, 2672, 2763, 2783, 2831, 2893, 2916, 2942, 2949, 3004, 3016, 3045, 3091, 3127, 3141, 3259, 3491, 3574, 3793, 3821, 3893, 3979, 4223, 4237], 'increased': [101, 127, 161, 174, 353, 379, 413, 426, 1599, 3352, 3359, 3481, 3529, 3538, 3920, 4373], 'that': [106, 151, 205, 217, 358, 403, 457, 469, 513, 618, 628, 754, 973, 1064, 1419, 1457, 1525, 1592, 1671, 1717, 3499, 3526, 3662, 3681, 3706, 3748, 3863, 3968, 4015, 4038, 4085, 4246, 4301, 4331], 'α-APPs': [107, 359, 2094, 4173, 4271, 4286, 4300, 4316, 4420], 'medium': [109, 361, 1190, 1781, 1819, 1823, 1830, 1845, 2486, 2512, 2629, 3085, 3194, 3330, 4320], 'C83': [112, 364, 1970, 2008, 4371, 4385, 4411], 'C-terminal': [113, 365, 1968, 4177], 'stub': [114, 366, 4179], 'membrane': [117, 158, 215, 369, 410, 467, 1608, 1649, 3306, 3833, 3856, 3914, 4193, 4335], 'rose.': [119, 202, 371, 454], 'β-secretase': [121, 373, 3946], 'APP,': [124, 376, 2204, 3511, 3702, 3709, 4045], 'C99,': [125, 377, 2205], 'also': [126, 201, 378, 453, 1066, 4056, 4372], 'modestly.': [128, 380], 'use': [130, 382], 'specific': [132, 384, 2399, 3688], 'γ-secretase': [133, 149, 239, 385, 401, 491, 1720, 1869, 4423], 'inhibitors': [134, 386, 1721], 'to': [135, 387, 568, 621, 747, 963, 992, 999, 1007, 1016, 1062, 1094, 1182, 1232, 1441, 1473, 1482, 1669, 1723, 1730, 1809, 1822, 1880, 1893, 1964, 1979, 2290, 2309, 2320, 2437, 2621, 2734, 2759, 2765, 2812, 3269, 3303, 3316, 3335, 3762, 3824, 3924, 3941, 3982, 4083, 4095, 4166, 4207, 4274], 'study': [136, 388], 'accumulation': [138, 390, 516, 1355, 4268], 'α-': [140, 165, 198, 392, 417, 450, 2106, 3944], 'β-cleavage': [142, 394], 'independent': [144, 396, 2197, 2996], 'their': [146, 398, 756], 'confirmed': [150, 402, 3877], 'results': [159, 411, 1378, 1597, 1715, 3407, 4330], 'β-secretases.': [167, 419], 'Unexpectedly,': [168, 420], 'secretion': [171, 423, 1349, 1631], 'was': [172, 424, 1624, 1763, 1820, 1835, 1851, 1876, 1889, 1988, 1997, 2009, 2060, 2081, 2095, 2129, 2144, 2336, 2428, 2572, 2634, 2687, 2725, 2802, 2810, 2859, 2873, 2963, 2981, 3112, 3298, 3351, 3375, 3382, 3399, 3469, 3759, 3834, 3873, 4021, 4055, 4228, 4287, 4321, 4377, 4406], 'significantly': [173, 425, 4023], 'as': [178, 430, 623, 976, 1448, 2338, 2531, 2919, 2984, 3006, 3261, 3802, 3858, 3876, 3906, 4194, 4209, 4336], 'detected': [179, 431, 1989, 2086, 2096, 2145, 2429, 2557, 3135, 4289], 'three': [181, 433, 2833, 2862, 2888, 2944, 2995, 3093, 3143], 'distinct': [182, 434, 1255], 'methods:': [183, 435], 'metabolic': [184, 436], 'labeling,': [185, 437], 'immunoprecipitation/Western': [186, 438], 'blotting,': [187, 439], 'enzyme-linked': [189, 441, 691], 'immunosorbent': [190, 442, 538, 692], 'assay.': [191, 443], 'Levels': [192, 444], 'p3': [194, 446, 2540], '(generated': [195, 447], 'sequential': [197, 449], 'γ-cleavage)': [200, 452], 'We': [203, 455, 1664, 3226, 3266, 3861, 4066, 4213], 'conclude': [204, 456, 1665, 3661], 'can': [208, 460, 629, 1421, 1673, 1680], 'be': [209, 461, 1422, 1674, 1681, 1728, 3917], 'produced': [210, 462, 1682], 'directly': [211, 463, 1685], 'alterations': [218, 470], 'degree': [221, 473], 'endocytosis': [224, 476, 1540, 1623, 3159, 3206, 3388, 3450, 3640, 3930, 4105], 'may': [225, 477, 974, 1727], 'help': [226, 478, 1459], 'regulate': [227, 479], 'its': [228, 480, 1353, 1437, 1446, 1614, 2188, 4093, 4163], 'production.': [229, 481], 'Our': [230, 482, 1690, 3406], 'findings': [231, 483, 1691, 3414], 'are': [232, 484, 1692, 2992, 3408, 3687, 4302], 'complex': [240, 492, 1701], 'numerous': [245, 497, 1706], 'single-transmembrane': [246, 498, 1707], 'receptors': [247, 499, 753, 3247], 'surface.': [251, 503, 1074, 1712, 3733, 4098], 'Genetic,': [504], 'neuropathological,': [505], 'biochemical,': [506], 'animal': [508], 'modeling': [509], 'studies': [510, 1252, 4183], 'all': [511], 'suggest': [512, 1253, 1716], 'progressive': [515], '(Aβ)': [521], '1The': [522], 'abbreviations': [523], 'are:': [525], 'Aβamyloid': [526], 'β-proteinAPPamyloid': [527], 'precursorRIPregulated': [529], 'intramembrane': [530, 632, 676], 'proteolysisBACEbeta-site': [531], 'cleaving': [533, 680], 'enzymeTGNtrans-Golgi': [534], 'networkERendoplasmic': [535], 'reticulumdyndynaminTricineN-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycineHAhemagglutininPASprotein': [536], 'A-SepharoseELISAenzyme-linked': [537], "assayHBSSHanks'": [539], 'balanced': [540, 695, 2837], 'salt': [541, 696, 2838], 'solutionWTwild': [542], 'typeADAMa': [543], 'disintegrin': [544, 701], 'metalloprotease': [546, 703], 'domainTACEtumor': [547], 'necrosis': [548, 706], 'factor': [549, 707], 'α': [550, 708], 'converting': [551, 709], 'enzymeTettetracyclinetfn-btntransferrin-biotinDAPTN-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine': [552], 't-butyl': [553, 714], 'ester.': [554, 715], 'limbic': [556], 'association': [558], 'cortices': [559], 'initiates': [560], 'Such': [563], 'has': [565, 610, 960, 1091, 1262, 1464], 'recently': [566], 'led': [567, 3334], 'development': [570], 'therapeutic': [572], 'agents': [573], 'aimed': [574], 'decreasing': [576], 'production': [578, 1726], 'or': [579, 1042, 1049, 1070, 1077, 1662, 1719, 1826, 1832, 1848, 2017, 2234, 2296, 2488, 2514, 2631, 2664, 2823, 2936, 3009, 3032, 3048, 4140], 'enhancing': [580], 'clearance': [582], 'Aβ.': [584, 1260], 'Despite': [585], 'this': [586, 1461, 1619, 3345], 'progress,': [587], 'unresolved': [590], 'question': [591, 609], 'remains:': [592], 'precisely': [593], 'where': [594], 'is': [598, 1060, 1453, 1472, 3241, 3513, 3565, 3710, 3777, 3953], 'generated': [600, 1423, 1675, 2227, 2266], 'from': [601, 1010, 1332, 1683, 1765, 1878, 1891, 2120, 2267, 2288, 2684, 3129, 3165, 3191, 4272], 'membrane-anchored': [603, 4178], '(APP)?': [607], 'This': [608, 3496], 'taken': [611], 'greater': [613, 3704], 'interest': [614], 'emerging': [616], 'appears': [620, 998], 'function': [622, 975, 1444, 3503, 4376], 'surface': [626, 808, 1015, 1175, 1223, 1336, 1451, 1535, 3347, 3508, 3772, 3921], 'receptor': [627, 1023, 1452, 1531, 3363], 'undergo': [630, 964, 1538], 'regulated': [631, 675], 'proteolysis': [633, 677], '(RIP)': [634], '(1Brown': [635], 'M.S.': [636, 660, 766, 1275], 'Ye': [637], 'J.': [638, 818, 850, 855, 877, 878, 898, 920, 944, 1109, 1139, 1159, 1208, 1366, 1399, 1514, 1549, 1574, 3215, 3431, 3649], 'Rawson': [639], 'R.B.': [640], 'Goldstein': [641], 'J.L.': [642], 'Cell.': [643], '2000;': [644, 781], '100:': [645], '391-398Abstract': [646], 'Full': [647, 649, 824, 826, 861, 863, 884, 886, 950, 952, 1115, 1145, 1147, 1165, 1214, 1405, 1407], 'Text': [648, 650, 825, 827, 862, 864, 885, 887, 951, 953, 1116, 1146, 1148, 1166, 1215, 1406, 1408], 'PDF': [651, 828, 865, 888, 954, 1117, 1149, 1167, 1216, 1409], 'PubMed': [652, 665, 771, 784, 798, 829, 866, 889, 924, 955, 1118, 1150, 1168, 1217, 1246, 1293, 1325, 1372, 1410, 1520, 1555, 1580, 2382, 3221, 3437, 3655, 4355], 'Scopus': [653, 666, 772, 785, 799, 830, 867, 890, 925, 956, 1151, 1247, 1294, 1326, 1373, 1411, 1521, 1556, 1581, 2383, 3222, 3438, 3656, 4356], '(1149)': [654], 'Google': [655, 668, 774, 787, 801, 832, 869, 892, 927, 958, 1119, 1153, 1169, 1218, 1249, 1296, 1328, 1375, 1413, 1523, 1558, 1583, 2385, 3224, 3440, 3658, 4358], 'Scholar,': [656, 775, 788, 1120, 1154, 1297, 1559], '2Esler': [657], 'W.P.': [658, 764], 'Wolfe': [659, 765], 'Science.': [661, 767, 794], '2001;': [662, 768], '293:': [663, 769], '1449-1454Crossref': [664, 770], '(472)': [667, 773], 'Scholar).': [669, 802, 1170, 1219, 1250, 1329, 1376, 1414, 1584, 3225, 4359], 'beta-site': [678], 'enzyme': [681, 710], 'trans-Golgi': [682, 1267], 'network': [683, 1268], 'endoplasmic': [684], 'reticulum': [685], 'N-[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]glycine': [687], 'hemagglutinin': [688], 'protein': [689, 1755, 1940, 1987, 2044, 3111], 'A-Sepharose': [690, 2045], 'assay': [693], "Hanks'": [694, 2836], 'solution': [697, 2839], 'wild': [698], 'type': [699], 'domain': [704, 738, 4165], 'tumor': [705], 'tetracycline': [711, 1761, 2516, 2584, 2633, 3011, 3190, 3326, 3667], 'transferrin-biotin': [712, 2858, 3286, 3302], 'N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine': [713], 'aspartyl': [722], 'proteases': [723], 'BACE/β-secretase': [724], 'presenilin/γ-secretase': [726, 1700], 'releases': [727], 'into': [729, 739, 1188, 1634, 2723, 3243, 4318], 'lumen/extracellular': [731], 'space': [732], 'liberates': [734], 'intracellular': [737, 971, 1259, 1354], 'cytoplasm': [741], 'process': [744], 'strikingly': [745], 'similar': [746, 3421], 'Notch': [752], 'enables': [755], 'signaling': [757, 1026], 'myriad': [759], 'fate': [761], 'decisions': [762], '(2Esler': [763], '3Selkoe': [776], 'D.J.': [777, 1108, 1132], 'Curr.': [778], 'Opin.': [779], 'Neurobiol.': [780], '10:': [782, 1244], '50-57Crossref': [783], '(67)': [786], '4Haass': [789], 'C.': [790, 842, 854, 1100, 1386, 1398], 'De': [791], 'Strooper': [792], 'B.': [793, 1303], '1999;': [795, 1142, 1243], '286:': [796], '916-919Crossref': [797], '(367)': [800], 'An': [803, 1455], 'increasing': [804], 'number': [805], 'proteins,': [809, 1536], 'including': [810], 'nectin-1α': [811], '(5Kim': [812], 'D.Y.': [813], 'Ingano': [814], 'L.A.': [815], 'Kovacs': [816], 'D.M.': [817], 'Biol.': [819, 856, 879, 945, 1110, 1140, 1160, 1209, 1368, 1400, 1516, 1551, 1576, 3217, 3433, 3651], 'Chem.': [820, 857, 880, 946, 1111, 1141, 1161, 1210, 1401], '2002;': [821, 858, 881, 921, 947], '277:': [822, 859, 882, 948], '49976-49981Abstract': [823], '(162)': [831], 'Scholar),': [833, 870, 893, 928, 959, 1524, 3441, 3659], 'CD44': [834], '(6Lammich': [835], 'S.': [836, 904, 912, 1124, 1158, 1207, 1279, 1569, 1767, 2377, 4350], 'Okochi': [837], 'M.': [838, 840, 2347, 2359], 'Takeda': [839], 'Kaether': [841], 'Capell': [843, 1389], 'A.': [844, 902, 1390, 2378, 4351], 'Zimmer': [845], 'A.K.': [846], 'Edbauer': [847], 'D.': [848, 1309, 2030, 2363, 2367, 2410, 2446], 'Walter': [849], 'Steiner': [851, 1393], 'H.': [852, 1394, 1507, 1542, 2361, 3208, 3424, 3642], 'Haass': [853, 1397], '44754-44759Abstract': [860], '(260)': [868, 891], 'LRP': [871], '(7May': [872], 'P.': [873, 896, 910, 2369, 2407, 2443], 'Reddy': [874], 'Y.K.': [875], 'Herz': [876], '18736-18743Abstract': [883], 'E-cadherin': [894], '(8Marambaud': [895], 'Shioi': [897], 'Serban': [899], 'G.': [900, 2353], 'Georgakopoulos': [901], 'Sarner': [903], 'Nagy': [905], 'V.': [906], 'Baki': [907], 'L.': [908, 941, 2371], 'Wen': [909], 'Efthimiopoulos': [911], 'Shao': [913], 'Z.': [914], 'Wisniewski': [915], 'T.': [916, 1283, 1299, 1388, 1509, 1544, 3210, 3426, 3644], 'Robakis': [917], 'N.K.': [918], 'EMBO': [919], '21:': [922], '1948-1956Crossref': [923], '(624)': [926], 'andErbB4': [929], '(9Lee': [930], 'H.J.': [931], 'Jung': [932], 'K.M.': [933], 'Huang': [934], 'Y.Z.': [935], 'Bennett': [936], 'L.B.': [937], 'Lee': [938, 1284, 1364, 2346], 'J.S.': [939], 'Mei': [940], 'Kim': [942], 'T.W.': [943], '6318-6323Abstract': [949], '(263)': [957], 'been': [961, 1092, 1380, 1465, 4205], 'discovered': [962], 'RIP,': [965, 985], 'some': [967, 2052], 'these': [969, 2248], 'releasing': [970], 'domains': [972], 'transcriptional': [977], 'regulators.': [978], 'Thus,': [979], 'rather': [986, 1628], 'than': [987, 1428, 1629, 3705], 'being': [988], 'an': [989, 1037, 1924, 2055, 2794, 3358, 3837, 3849, 3983], 'anomaly': [990], 'related': [991], 'pathogenesis': [994], 'disease,': [997], 'represent': [1000], 'conserved': [1002], 'mechanism': [1003], 'employed': [1004], 'communicate': [1008], 'information': [1009], 'events': [1011], 'nucleus.': [1018], 'Because': [1019, 3628], 'initiation': [1021], 'endoproteolysis': [1024], 'often': [1027], 'requires': [1028], 'binding': [1030, 3301, 3348], 'cognate': [1033], 'ligand': [1034], 'located': [1035], 'adjacent': [1038, 3823], '(e.g.': [1040, 1053], 'Delta': [1041], 'Jagged': [1043], 'case': [1046, 1056], 'Notch)': [1048], 'else': [1050], 'intercellular': [1051], 'adhesion': [1052], 'E-cadherin),': [1058], 'it': [1059, 1679], 'reasonable': [1061], 'hypothesize': [1063], 'undergoes': [1067], 'near': [1071], 'Indeed,': [1075], 'deletion': [1076], 'mutation': [1078, 1500], 'cytoplasmic': [1081, 2078], 'YENPTY': [1082], 'motif': [1083], 'important': [1084], 'internalization': [1087, 1198, 1528, 3237], 'surface-inserted': [1089], 'reported': [1093, 4206], 'sharply': [1095], 'reduce': [1096], 'generation': [1098, 1439, 3162, 4017], '(10Haass': [1099], 'Hung': [1101], 'A.Y.': [1102], 'Schlossmacher': [1103], 'M.G.': [1104], 'Teplow': [1105], 'D.B.': [1106], 'Selkoe': [1107, 1131], '1993;': [1112], '268:': [1113], '3021-3024Abstract': [1114], '11Perez': [1121], 'R.G.': [1122], 'Soriano': [1123], 'Hayes': [1125], 'J.D.': [1126], 'Ostaszewski': [1127], 'B.L.': [1128], 'Xia': [1129], 'W.': [1130], 'Chen': [1133], 'X.': [1134], 'Stokin': [1135], 'G.B.': [1136], 'Koo': [1137], 'E.H.': [1138, 1156, 1205], '274:': [1143], '18851-18856Abstract': [1144], '(342)': [1152], '12Koo': [1155], 'Squazzo': [1157, 1206], '1994;': [1162, 1211, 1517, 1552, 3218, 3434, 3652], '269:': [1163, 1212], '17386-17389Abstract': [1164, 1213], 'Moreover,': [1171, 1713], 'selective': [1172, 4108], 'labeling': [1173], 'molecules': [1177, 3718], 'living': [1179], 'leads': [1181, 1231], 'release': [1184, 4167], 'labeled': [1186, 4086], 'time': [1193, 2565, 4062, 4120], 'course': [1194, 2566], 'recycling': [1201], '(12Koo': [1204], 'Furthermore,': [1220, 3693], 'trypsinization': [1221, 3139], 'proteins': [1224, 1480, 1708, 2155, 2250, 2724, 2733, 3773], 'human': [1226], 'brain': [1227], 'ex': [1229], 'vivo': [1230], 'decrease': [1234], 'secreted': [1236, 4270, 4317], '(13Jung': [1238], 'S.S.': [1239, 4344], 'Cashman': [1240], 'N.R.': [1241], 'Neuroreport.': [1242], '3875-3879Crossref': [1245], '(8)': [1248], 'Other': [1251], 'pathway': [1256, 4189], 'generating': [1258], 'Immunocytochemistry': [1261], 'revealed': [1263], '(TGN)': [1269], 'ER': [1271, 3855], '(14Cook': [1272], 'D.G.': [1273, 1361], 'Forman': [1274], 'Sung': [1276], 'J.C.': [1277], 'Leight': [1278], 'Kolson': [1280], 'D.L.': [1281], 'Iwatsubo': [1282], 'V.M.Y.': [1285], 'Doms': [1286, 1362], 'R.W.': [1287, 1363], 'Nat.': [1288, 1320], 'Med.': [1289, 1321], '1997;': [1290, 1322, 1369, 1402, 2379], '3:': [1291, 1323], '1021-1023Crossref': [1292], '(430)': [1295], '15Hartmann': [1298], 'Bieger': [1300], 'S.C.': [1301], 'Bruhl': [1302], 'Tienari': [1304], 'P.J.': [1305], 'Ida': [1306], 'N.': [1307], 'Allsop': [1308], 'Roberts': [1310], 'G.W.': [1311], 'Masters': [1312], 'C.L.': [1313], 'Dotti': [1314], 'C.G.': [1315], 'Unsicker': [1316], 'K.': [1317, 1319, 1567, 2345, 2351, 2357], 'Beyreuther': [1318], '1016-1020Crossref': [1324], '(645)': [1327], 'Preventing': [1330], 'reaching': [1333], 'treating': [1338], 'NT2N': [1339], '(differentiated': [1340], 'NT2': [1341], 'cells)': [1342], 'neurons': [1343], 'brefeldin': [1345], 'A': [1346, 3756], 'abrogated': [1347], 'but': [1350, 1463, 2107], 'resulted': [1351], '(16Chyung': [1356], 'A.S.C.': [1357], 'Greenberg': [1358], 'B.D.': [1359], 'Cook': [1360], 'V.M.-Y.': [1365], 'Cell': [1367, 1515, 1550, 1575, 1744, 2639, 3216, 3432, 3650], '138:': [1370], '671-680Crossref': [1371], '(137)': [1374], 'Similar': [1377], 'have': [1379, 1487, 3721, 4184, 4204], 'obtained': [1381, 1764], 'non-neural': [1383], '(17Wilde-Bode': [1385], 'Yamazaki': [1387], 'Leimer': [1391], 'U.': [1392, 2376, 4349], 'Ihara': [1395], 'Y.': [1396, 1561], '272:': [1403], '16085-16088Abstract': [1404], '(286)': [1412], 'Therefore,': [1415], 'available': [1416], 'suggests': [1418], 'accumulate': [1425], 'more': [1427], 'one': [1429], 'subcellular': [1430], 'locus.': [1431], 'Whether': [1432], 'principal': [1434, 4338], 'site': [1435, 4339], 'proteolytic': [1438, 1641, 2189, 3936], 'relates': [1440], 'putative': [1443], 'unclear.': [1454], 'approach': [1456], 'could': [1458, 3916, 4395], 'clarify': [1460], 'issue': [1462], 'little': [1466], 'exploited': [1467], 'research': [1469], 'take': [1474], 'advantage': [1475], 'mutants': [1478], 'known': [1481], 'mediate': [1483], 'endocytosis.': [1484, 3250], 'systematically': [1488], 'characterized': [1489, 1498], 'well': [1497], '(dyn),': [1504], 'K44A': [1505, 1596, 1754, 1811, 1986, 3148, 3234, 3255, 3341, 3381, 3468, 3583, 3686, 3714, 3898, 4027, 4143, 4227, 4251, 4279, 4405], '(18Damke': [1506, 1541, 3207, 3423, 3641], 'Baba': [1508, 1543, 3209, 3425, 3643], 'Warnock': [1510, 1545, 3211, 3427, 3645], 'D.E.': [1511, 1546, 3212, 3428, 3646], 'Schmid': [1512, 1547, 1572, 1768, 3213, 3429, 3647], 'S.L.': [1513, 1548, 1573, 3214, 3430, 3648], '127:': [1518, 1553, 3219, 3435, 3653], '915-934Crossref': [1519, 1554, 3220, 3436, 3654], '(1040)': [1522, 1557, 3223, 3439, 3657], 'transferrin': [1530, 2141, 3246, 3257, 3272, 3297, 3350, 3362, 3374], 'certain': [1533], 'other': [1534], '19Altschuler': [1560], 'Barbas': [1562], 'S.M.': [1563], 'Terlecky': [1564], 'L.J.': [1565], 'Tang': [1566], 'Hardy': [1568], 'Mostov': [1570], 'K.E.': [1571], '1998;': [1577], '143:': [1578], '1871-1881Crossref': [1579], '(187)': [1582], 'Using': [1585], 'expression': [1588], 'system,': [1589], 'find': [1591], 'endogenous,': [1602], 'full-length': [1603, 1981, 3125, 3623], 'consequent': [1611], 'increase': [1612, 1638, 3520, 3750, 3911, 4418], 'α-secretase.': [1617], 'Surprisingly,': [1618], 'inhibition': [1620, 3447, 3500, 3927, 3942], 'associated': [1625], 'more,': [1627], 'less,': [1630], 'medium.': [1636, 2425, 2506], 'turnover': [1642], 'held': [1645], 'occurred': [1650], 'absence': [1653, 3324, 3580], 'detectable': [1655, 3593], 'changes': [1656], 'presenilin/γ-secretase.': [1663], 'that,': [1666], 'addition': [1668, 3070], 'during': [1676], 'endosomal': [1677], 'recycling,': [1678], 'critical': [1696], 'our': [1714], 'intended': [1722], 'lower': [1724], 'able': [1729], 'operate': [1731], 'principally': [1732, 3505, 3715, 3760], 'membrane,': [1736, 3769], 'without': [1737, 1833, 1849, 2489, 2515, 2632, 3010, 3030, 3049, 4141], 'need': [1739], 'full': [1741], 'penetration.': [1743], 'Culture—An': [1745], 'line': [1748, 3172, 3419, 3609], 'under': [1756, 3182, 3420], 'control': [1758, 3184, 4284], 'transactivator': [1762], 'Dr.': [1766], '(Scripps': [1769], 'Institute,': [1770], 'La': [1771], 'Jolla,': [1772], 'CA).': [1773, 2036, 2127, 2416, 2452], 'Cells': [1774, 1803, 2507, 2611, 2892, 2948, 3015, 3044, 3090], 'grown': [1776], "Dulbecco's": [1778, 2617], 'modified': [1779], "Eagle's": [1780], 'containing': [1782, 1825, 1910, 2517, 2647, 2717, 2900, 3086, 3105, 3798], '10%': [1783, 1973, 2690], 'fetal': [1784, 3087], 'bovine': [1785, 3088], 'serum,': [1786], '100': [1787, 1790, 2712, 2967, 3799], 'μg/ml': [1788, 1791, 1794, 1801, 2397], 'penicillin,': [1789], 'streptomycin,': [1792], '200': [1793, 1796], 'G418,': [1795], 'ng/ml': [1797], 'puromycin,': [1798], '1': [1800, 1806, 1872, 1886, 2467, 2518, 2709, 3024, 3050, 3057, 3072], 'tetracycline.': [1802, 1828, 2490], 'split': [1805], 'day': [1807, 1815], 'prior': [1808], 'induction.': [1812, 1897, 4144], 'On': [1813], 'induction,': [1817, 1884, 2495, 3346, 3899, 4280], 'changed': [1821, 1836], 'either': [1824], 'lacking': [1827], '(with': [1831], 'tetracycline)': [1834, 1850], 'again': [1837, 3894], 'after': [1838, 2654, 3719, 3864, 4114], '30': [1839, 2500, 2596, 2884, 3061], 'min.': [1840, 2610, 2670, 2679, 2914, 4065], 'Ten': [1841], 'milliliters': [1842], 'fresh': [1844], '(again': [1846], 'added': [1852, 2308, 2635], '24': [1854, 1879, 2289, 2492, 2524, 2826, 4273], 'h': [1855, 1882, 1895, 2292, 2493, 2827, 2941, 3197, 3333, 3403, 4276], 'post-induction,': [1856], 'conditioned': [1860, 2285, 2510], 'media': [1861, 2311], 'collected': [1863, 2287, 2528, 2653], '48': [1865, 1881, 1892, 2291, 2590, 2940, 3196, 3332, 3402, 4275], 'h.': [1866, 2525, 3014], 'For': [1867], 'inhibitor': [1870, 1913, 2305, 2650, 2903, 3078, 3108], 'studies,': [1871], 'μm': [1873, 1887], 'Compound': [1874], 'E': [1875], 'applied': [1877, 1890], 'DAPT': [1888], '52': [1894], 'Immunoprecipitation': [1898], 'Western': [1900, 1954, 2172, 2182, 2200, 2242, 2268, 2917, 2989, 3121, 3811], 'Blotting—Cells': [1901], 'lysed': [1903, 2894, 3098], '1%': [1905, 2642, 2718, 2770, 3100], 'Nonidet': [1906, 2643, 2771, 3101], 'P-40': [1907, 2644, 2772, 2897, 3102], 'lysis': [1908, 2645, 2773, 2898, 3103], 'buffer': [1909, 2646, 2899, 3104], 'Complete': [1911, 2303, 2648, 2901, 3106], 'protease': [1912, 2304, 2649, 2902, 3107], 'mixture': [1914], '(Roche': [1915, 1992, 2005], 'Applied': [1916], 'Science,': [1917], 'Indianapolis,': [1918], 'IN).': [1919], 'Nuclei': [1920, 2671], 'pelleted': [1922, 2673, 2907], 'Eppendorf': [1925], 'centrifuge': [1926, 2327], '(Brinkman': [1927], 'Instruments,': [1928], 'Inc.,': [1929, 2091], 'Westbury,': [1930], 'NY)': [1931], '2': [1933, 2472, 2602, 2678, 2913, 3999], 'min': [1934, 2319, 2468, 2473, 2501, 2597, 2663, 2695, 2705, 2847, 2958, 3062, 3275, 3781, 4082], '14,000': [1936, 2675, 2701, 2910], '×': [1937], 'g.': [1938], 'Equal': [1939, 3110], 'amounts,': [1941], 'determined': [1942, 2573, 2874, 4266], 'using': [1943, 2097, 2146, 2213, 2262, 2558, 2793, 3415], 'DC': [1945], 'Protein': [1946], 'Assay': [1947], '(Bio-Rad,': [1948], 'Hercules,': [1949], 'CA),': [1950], 'blotting.': [1955, 3122], '10-20%': [1956, 2553], 'Tris-Tricine': [1957, 2554], 'gels': [1958, 1975, 2555], '(Invitrogen,': [1959], 'Carlsbad,': [1960], 'CA)': [1961, 2239], 'separate': [1965, 1980], 'fragments,': [1969], 'C99.': [1972], 'Tris-glycine': [1974, 2789, 3117], '(Invitrogen)': [1976, 2620, 3034, 3040], 'species.': [1983], 'HA-tagged': [1984], '12CA5': [1991], 'Molecular': [1993, 2006], 'Biochemicals).': [1994, 2007], 'Full-length': [1995], 'blotted': [1998, 2010, 2117, 2137, 2165, 2918], 'N-terminal-specific': [2001], 'monoclonal': [2002, 2025], 'antibody,': [2003, 2100], '22C11': [2004, 2167], 'C-terminal-specific': [2013], 'polyclonal': [2014, 2099, 2132], 'antibody': [2015, 2026, 2133, 2433, 2459, 3838, 3850, 4291], 'C8,': [2016, 2059], 'C8': [2019, 2065, 2084, 3133], 'immunoprecipitation': [2020], 'followed': [2021, 2971], 'blotting': [2023, 2243, 4384], '13G8': [2027, 2067], '(gift': [2028, 2405, 2441], 'Schenk,': [2031, 2411, 2447], 'Elan': [2032, 2448], 'Pharmaceuticals,': [2033, 2449], 'San': [2034, 2414, 2450], 'Francisco,': [2035, 2415, 2451], 'All': [2037, 2181], 'immunoprecipitated': [2038, 2082, 2130, 2157, 2544, 2779, 3128], 'samples': [2039, 2280, 3131], 'first': [2041, 4214], 'pre-cleared': [2042, 2537, 2775], '(PAS)': [2046], '(Sigma-Aldrich,': [2047], 'St.': [2048], 'Louis,': [2049], 'MO).': [2050], 'In': [2051, 4034, 4242, 4307, 4360], 'experiments,': [2053], 'C7,': [2054], 'affinity-purified': [2056], 'form': [2057, 3509, 3870], 'used.': [2061], 'epitopes': [2063], 'lie': [2068], 'last': [2071, 4296], '20': [2072, 2465, 2662, 2694, 4011, 4064], 'amino': [2073, 4158], 'acids': [2074, 4159], 'domain.': [2079], 'C99': [2080, 2225, 2235, 3123], '6E10': [2088], '(Signet': [2089], 'Laboratories,': [2090], 'Dedham,': [2092], 'MA).': [2093], '1736,': [2101, 4292], 'specifically': [2103, 4288], 'recognizes': [2104, 4294], 'not': [2108, 2937, 3626, 3980, 4022, 4253, 4303], 'β-secretase-generated': [2110], 'ectodomain': [2111, 3842, 4170], 'fragment.': [2112], 'Tubulin': [2113, 3570], 'ribophorin': [2115, 2170, 3572, 3892, 3904], 'antibodies': [2119, 4389], 'Santa': [2121], 'Cruz': [2122], 'Biotechnology,': [2123, 2150], 'Inc.': [2124], '(Santa': [2125], 'Cruz,': [2126], '1282': [2134, 2546], 'then': [2136, 2241, 2471, 2509, 2599, 2784, 2851, 2886, 3017, 3066, 3280, 3311], '6E10.': [2139, 3137], 'Biotinylated': [2140], '(tfn-btn,': [2142], 'Sigma-Aldrich)': [2143, 2301], 'neutravidin-horseradish': [2147], 'peroxidase': [2148], '(Pierce': [2149], 'Rockford,': [2151], 'IL).': [2152], 'Surface': [2153, 2928, 2987, 2998, 3138], 'biotinylated': [2154, 2431, 2950, 2979, 2988, 3271, 3771], 'streptavidin-agarose': [2159, 3808], '(Molecular': [2160], 'Probes,': [2161], 'Eugene,': [2162], 'OR)': [2163], 'antibody.': [2171], 'blots': [2173, 2183, 2269, 2990], 'developed': [2175], 'Pierce': [2177], 'Femto': [2178], 'SuperSignal': [2179], '(Pierce).': [2180, 2479], 'shown': [2184, 2991, 3949], 'repeated': [2192, 2803, 3142, 3288], 'least': [2195], 'five': [2196], 'experiments.': [2198, 2997], 'Quantitative': [2199], 'Blotting—Mature': [2201], 'immature': [2203, 3536, 3708, 4019, 4134], 'tfn-btn': [2207, 2259, 2844, 2879], 'quantified': [2210, 2261, 3260, 3518], 'densitometry': [2212], 'ImageQuaNT': [2214], 'software': [2215], '(Amersham': [2216, 2562], 'Biosciences,': [2217], 'Piscataway,': [2218], 'NJ).': [2219], 'Standard': [2220], 'curves': [2221], 'transiently': [2229], 'transfecting': [2230], 'plasmids': [2231], 'encoding': [2232], 'APP695': [2233], '(Effectene,': [2236], 'Qiagen,': [2237], 'Valencia,': [2238], '2-fold': [2244, 2272], 'serial': [2245, 2271], 'dilutions': [2246, 2273], 'overexpressed': [2249], 'parallel': [2252, 2277, 4414], 'experimental': [2254, 2279], 'samples.': [2255, 3827], 'Surface-bound': [2256, 2871, 3296], 'internalized': [2258, 3262, 3294], 'standard': [2264], 'curve': [2265], 'tfn-biotin,': [2275], 'ELISA.': [2282], 'Media': [2283, 2526], 'non-induction.': [2297], '1,10-Phenanthroline': [2298], '(2': [2299], 'mm,': [2300], 'mix': [2306, 2651], 'spun': [2313, 2699], '3,000': [2315], 'rpm': [2316, 2676, 2702, 2911], '10': [2318, 2704, 3037], 'remove': [2321, 3317], 'debris': [2322], 'Marathon': [2325], '8K': [2326], '(Fisher': [2328], 'Scientific,': [2329], 'Pittsburgh,': [2330], 'PA).': [2331], 'ELISA': [2332, 2533], 'X-40': [2335], 'performed': [2337, 3990, 4068], 'described': [2339, 2920, 2985], 'Johnson-Wood': [2341], 'et': [2342], 'al.': [2343], '(20Johnson-Wood': [2344], 'Motter': [2348], 'R.': [2349, 2355], 'Hu': [2350], 'Gordon': [2352, 2358], 'Barbour': [2354], 'Khan': [2356], 'Tan': [2360], 'Games': [2362], 'Lieberburg': [2364], 'I.': [2365], 'Schenk': [2366], 'Seubert': [2368, 2408, 2444], 'MConlogue': [2370], 'Proc.': [2372, 4345], 'Natl.': [2373, 4346], 'Acad.': [2374, 4347], 'Sci.': [2375, 4348], '94:': [2380], '1550-1555Crossref': [2381], '(584)': [2384], 'Scholar)': [2386], 'following': [2389, 3784], 'modifications.': [2390], '96-well': [2391], 'plates': [2392, 2830], 'coated': [2394], '3': [2396], '2G3,': [2398], 'Aβ40': [2402], 'C': [2403], 'terminus': [2404], 'Athena': [2412], 'Neurosciences,': [2413], 'Standards': [2417], '1-40': [2420], 'diluted': [2422, 2764], 'unconditioned': [2424], 'Bound': [2426], '266': [2432], '(0.25': [2434], 'μg/ml),': [2435], 'directed': [2436], 'Aβ13-28': [2439], 'region': [2440], 'Plates': [2453], 'washed': [2455, 2613, 2832, 2943, 3018, 3092, 3794], 'two': [2456, 2973], 'times': [2457, 2657, 2834, 2889, 2945, 3094, 4006, 4075, 4090], 'between': [2458, 4025], 'incubations': [2460], 'Tris-buffered': [2462], 'saline/0.05%': [2463], 'Tween': [2464], 'each,': [2469], 'each': [2474, 2685], 'before': [2475], 'developing': [2476], 'tetramethylbenzidine-ELISA': [2478], 'Metabolic': [2480], 'Labeling—HeLa': [2481], 'cultured': [2484], 'At': [2491], 'incubated': [2498, 2842], 'Cys/Met-free': [2503], 'serum-free': [2505], 'mCi': [2519, 2603, 4000], '[35S]Cys,': [2521, 4002], '[35S]Met': [2522, 2607], 'prepared': [2530], '(above).': [2534], 'Samples': [2535, 2549, 2757, 2782, 2915, 3792], 'PAS.': [2539, 2548], 'run': [2551, 2785], 'E425': [2560, 2797], 'PhosphorImager': [2561], 'Biosciences).': [2563], 'biosynthesis': [2569], 'maturation': [2571], 'pulse-chase': [2575, 3992, 4071], 'experiments': [2576, 3140], '10-cm': [2581, 2930], 'dishes.': [2582], 'After': [2583], '(or': [2586], 'no': [2587, 3592, 3617, 3901], 'induction)': [2588], 'h,': [2591], 'serum-starved': [2594], 'pulsed': [2600], '[35S]Cys': [2605], 'plus': [2606, 3478], '7': [2609, 2846, 3274], 'once': [2614], 'briefly': [2615], 'phosphate-buffered': [2618], 'saline': [2619], 'terminate': [2622], 'pulse,': [2624], '5': [2626], 'ml': [2627, 2710, 2736, 3051, 3073, 3082], 'chase.': [2638], 'lysates': [2640, 3820], 'cold': [2655], 'chase': [2656, 4005, 4074], '0,': [2659, 2665, 4008, 4077], '10,': [2660, 4009], '30,': [2666, 4078], '60,': [2667, 4079], '90': [2669, 4081], '25': [2680], 'μl': [2681, 2730], 'lysate': [2683, 3886], 'sample': [2686], 'precipitated': [2688, 3806], 'trichloroacetic': [2691], 'acid': [2692, 2864, 3289], '4': [2697, 2735, 2854, 2881, 2960, 3021, 3064, 3308], '°C,': [2698, 3065], 'resolubilized': [2707, 2732], 'mm': [2713, 2968, 3025, 3038, 3042, 3058, 3800], 'Tris-HCl,': [2714], 'pH': [2715, 2869], '8,': [2716], 'SDS.': [2719], 'Incorporation': [2720], 'radiolabel': [2722], 'measured': [2726, 3299], 'adding': [2728], '40': [2729], 'EcoScint': [2738], 'H': [2739], '(National': [2740], 'Diagnostics,': [2741], 'Atlanta,': [2742], 'GA)': [2743], 'counted': [2745], '1212': [2748], 'Rackbeta': [2749], 'liquid': [2750], 'scintillation': [2751], 'counter': [2752], '(LKB': [2753], 'Wallac,': [2754], 'Gaithersburg,': [2755], 'MD).': [2756], 'corresponding': [2758], 'equal': [2760], 'radioactive': [2761], 'counts': [2762], '1-ml': [2767], 'volume': [2768], 'buffer,': [2774], 'PAS,': [2777], 'C8.': [2781], '4-20%': [2788, 3116], 'gel': [2790, 3118], 'Amersham': [2795], 'Biosciences': [2796], 'PhosphorImager.': [2798], 'Each': [2799], 'radiolabeled': [2800], 'blot': [2801], 'twice.': [2804], 'Transferrin': [2805], 'Uptake': [2806], 'Assays—tfn-btn': [2807], '(8': [2808], 'μg/ml)': [2809], 'determine': [2813], 'kinetics': [2815], 'tfn': [2817, 2872], 'uptake.': [2818], 'Briefly,': [2819], 'induced': [2822, 2935, 2938, 3383, 3400, 3599, 4028], 'non-induced': [2824, 4030], 'six-well': [2829], '(HBSS)': [2840], '(Invitrogen),': [2841], 'culture': [2849, 3084, 3193, 3329], 'medium,': [2850], 'placed': [2852], '°C.': [2855, 2961], 'Remaining': [2856], 'surface-bound': [2857, 3284], 'removed': [2860], 'brief': [2863], 'washes': [2865], 'HBSS': [2867, 2974, 3029, 3096, 3315, 3797], '4.': [2870], 'incubating': [2876], '°C': [2882, 3022, 3278, 3309], 'min,': [2885, 4012], 'washing': [2887, 3313], 'HBSS.': [2891, 2947], '1%Nonidet': [2896], 'mix,': [2904], 'nuclei': [2906], 'above': [2921, 3007], 'qualitative': [2924], 'quantitative': [2926], 'analysis.': [2927, 3993], 'Biotinylation—Confluent': [2929], 'dishes': [2931, 3000], '0.5': [2952], 'mg/ml': [2953], 'Sulfo-NHS-LC-Biotin': [2954], '(Pierce)': [2955], '45': [2957, 3780], 'Biotinylation': [2962], 'quenched': [2964, 3067], 'glycine/HBSS': [2969], 'wash': [2970], 'washes.': [2975], 'Immunoprecipitation/Western': [2976], 'analysis': [2977], 'materials': [2980], 'carried': [2982], 'out': [2983], 'above.': [2986], 'representative': [2993], 'Trypsinization—10-cm': [2999], 'treated': [3005, 3046], '44': [3013], 'twice': [3019], 'EDTA': [3026], '(Sigma)': [3027], 'Ca2+': [3031], 'Mg2+': [3033], 'buffered': [3035], 'HEPES': [3039], '(1': [3041], 'EDTA/HBSS/HEPES).': [3043], '0.25%': [3053], 'trypsin': [3054, 3077], '(Sigma-Aldrich)': [3055, 3079], 'EDTA/HBSS/HEPES': [3059], '0.125%': [3075], 'soybean': [3076], '8': [3081], 'serum.': [3089], 'mixture.': [3109], 'loaded': [3113, 3822], 'tubulin': [3120, 3589], 'protein-normalized': [3130], 'times.': [3144], 'Induction': [3145], 'Dynamin': [3147, 3459, 3737, 3965, 4151], 'Potently': [3150], 'Blocks': [3151], 'Receptor-mediated': [3152], 'Endocytosis—We': [3153], 'investigated': [3154], 'utilizing': [3168], 'transfected': [3174], 'construct,': [3179], 'tetracycline-responsive': [3187], 'element.': [3188], 'Removing': [3189], 'induces': [3198], 'potently': [3203], 'began': [3227], 'verifying': [3229], 'transferrin,': [3239], 'brought': [3242], 'through': [3248, 3723, 4051], 'clathrin-mediated': [3249, 3387], 'uptake': [3258, 3372], 'transferrin/surface-bound': [3263, 3390], 'transferrin/unit': [3264, 3391], 'time.': [3265], 'allowed': [3267], 'internalize': [3270], '37': [3277], 'detached': [3281], 'residual': [3283], '(non-internalized)': [3285], 'washes,': [3290], 'thus': [3291], 'measuring': [3292], 'transferrin.': [3295], 'repeatedly': [3312], 'non-specifically': [3318], 'bound': [3319], 'transferrin-biotin.': [3320], 'As': [3321, 3547, 3813, 3948, 4099], 'expected,': [3322, 4100], 'strong': [3337, 4417], '(Fig.': [3342, 3355, 3384, 3404, 3494, 3545, 3584, 3754, 3887, 3908, 3931, 4032, 4324, 4379], '1A).': [3343], 'Following': [3344, 3994], '∼68%': [3354], '1B),': [3356], 'reflecting': [3357, 4046], 'Accordingly,': [3368], 'total': [3370, 3472, 4257], 'bulk': [3371], 'decreased': [3376, 3393, 3935], '∼58%': [3378], 'when': [3379, 3396, 4225, 4374], '1C).': [3385], 'Overall,': [3386], '(internalized': [3389], 'time)': [3392], '75%': [3395], '1D).': [3405], 'entirely': [3409], 'previously': [3412], 'published': [3413], 'same': [3417], 'conditions': [3422], 'they': [3443, 3720], 'confirm': [3444, 3747, 4084], 'potent': [3446], 'K44A.': [3455, 3791], 'Expression': [3456, 3734], 'Dominant-negative': [3458, 3736], 'Selectively': [3460], 'Increases': [3461, 4149], 'Level': [3463], 'Mature': [3465], 'APP—When': [3466], 'induced,': [3470, 4407], 'cellular': [3473, 3752, 4258], 'mature,': [3476], 'N-': [3477], 'O-glycosylated': [3479], 'robustly,': [3482], 'whereas': [3483, 3535, 4133], 'immature,': [3488], 'N-glycosylated': [3489], 'minimally': [3492], 'elevated': [3493, 4323], '2A).': [3495], 'result': [3497], 'suggested': [3498], 'affected': [3504], 'fully': [3514, 4042], 'glycosylated.': [3515], 'When': [3516, 3597, 4150, 4403, 4422], 'holoAPP': [3522, 3915, 3939], 'levels,': [3523], 'found': [3525, 3616, 3862, 4014, 4037], '∼500%': [3531], '(p': [3532, 3542], '<': [3533, 3543], '0.0005),': [3534], 'only': [3540], '47%': [3541], '0.0003)': [3544], '2B).': [3546], 'negative': [3548], 'controls,': [3549], 'examined': [3551], 'cytosolic': [3556], 'protein,': [3557, 3562, 3857], 'tubulin,': [3558], 'transmembrane': [3561, 4164], 'ribophorin,': [3563, 3852], 'retained': [3566], 'ER.': [3569], 'unchanged': [3575, 3895, 4057, 4239], 'presence': [3578, 3665, 4309], 'versus': [3579], '2C);': [3585], 'quantitation': [3586], 'signal': [3590], 'showed': [3591, 4106], 'difference': [3594, 3618], '(not': [3595, 4240, 4262], 'shown).': [3596, 3627, 4241, 4263], 'overexpression': [3601, 3629, 3670], 'tet-off': [3606], 'wild-type': [3612], '(WT)': [3613], 'dynamin,': [3614, 4312], '(data': [3625], 'WT': [3631, 3672], 'exerts': [3633], 'minimal': [3635], 'influence': [3636], 'rates': [3638], 'neither': [3663], 'nor': [3668], 'increases': [3674], 'levels.': [3677, 4421], 'These': [3678, 4326], 'data': [3679, 4327], 'indicate': [3680], 'dynamin.': [3692], 'dramatic': [3695], 'rise': [3696, 4109, 4365], 'level': [3699], '∼10-fold': [3703], 'affecting': [3716], 'passed': [3722], 'pathway,': [3726, 3988], 'completed': [3727], 'glycosylation,': [3728], 'reached': [3730], 'Results': [3738], 'Accumulation': [3740], 'Plasma': [3745], 'Membrane—To': [3746], '2,': [3755], 'B)': [3758], 'due': [3761, 3923, 3940, 3981], 'sulfo-NHS-LC-biotin,': [3775], 'cell-impermeant,': [3778], 'ice': [3783], '48-h': [3786], 'induction/no': [3787], 'thoroughly': [3795], 'glycine': [3801], 'quenching': [3804], 'reagent,': [3805], 'beads,': [3809], 'blotted.': [3812], 'controls': [3814], 'migration,': [3817], 'straight': [3818, 3885], 'streptavidin-precipitated': [3826], 'top': [3829], 'portion': [3830, 3847], 'immunoblotted': [3835], 'against': [3839, 3851], '(22C11),': [3843], 'bottom': [3846], 'resident': [3854], 'control.': [3860], 'expression,': [3867], 'biotinylated,': [3875], 'co-migration': [3879], '2D).': [3888], 'biotinylation': [3902], 'occurred,': [3905], 'expected': [3907], '2E).': [3909], 'caused': [3918], 'documented': [3926], '1)': [3932], 'and/or': [3933, 3945], 'activity.': [3947, 4198], 'below,': [3950], 'former': [3952], 'explanation.': [3955], 'Biosynthesis': [3956], 'Maturation': [3958], 'Are': [3961], 'Not': [3962], 'Affected': [3963], 'Function—To': [3966], 'prove': [3967], 'dysfunction': [3973], 'trafficking': [3976, 4048], 'effect': [3984], '7-min': [3996], 'pulse': [3997], '[35S]Met,': [4003], 'different': [4024], '2F).': [4033], 'addition,': [4035, 4243], 'appearance': [4040], 'Golgi': [4053], 'apparatus,': [4054], 'earliest': [4060], 'detection': [4061], 'next': [4067], 'second': [4070], 'experiment': [4072], 'accumulates': [4088], 'delivery': [4094], 'blocked': [4104], '60-': [4116], '90-min': [4118], 'chases,': [4119], 'points': [4121], 'arrival': [4125], 'fell': [4137], 'equally': [4138], 'α-Secretase': [4145], 'Cleavage': [4146], 'Function': [4152], 'Is': [4153], 'Down-regulated—α-Secretases': [4154], 'cleave': [4155], '12': [4157], 'front': [4161], 'soluble': [4169], 'fragment': [4171], 'called': [4172], 'leave': [4175], 'termed': [4180], 'C83.': [4181, 4402], 'Prior': [4182], 'implicated': [4185], 'sites': [4195], 'Both': [4199], 'ADAM10': [4200, 4220, 4234], 'ADAM17': [4202], '(TACE)': [4203], 'serve': [4208], 'α-secretases': [4210], 'asked': [4215], 'if': [4216], 'TACE': [4222, 4236], 'altered': [4224], 'induced.': [4229], 'established': [4245], 'did': [4252], 'alter': [4254], 'presenilin': [4259], 'nicastrin': [4261], 'Next,': [4264], 'compared': [4281], 'uninduced': [4283], 'cultures.': [4285], '16': [4297], 'residues': [4298], 'present': [4304], 'β-APPs.': [4306], 'quantity': [4314], 'markedly': [4322], '3A).': [4325], 'support': [4328], 'previous': [4329], 'identified': [4332], 'activity': [4342, 4424], '(21Sisodia': [4343], '1992;': [4352], '89:': [4353], '6075-6079Crossref': [4354], '(632)': [4357], 'accord': [4361], 'marked': [4364], 'α-APPs,': [4367], 'suppressed': [4378], '3B).': [4380], 'By': [4381], 'immunoprecipitating': [4382], 'highly': [4387], 'sensitive': [4388], '(C7': [4390], '13G8,': [4392], 'respectively),': [4393], 'detect': [4396], 'small': [4398], 'amount': [4399], 'rose,': [4412], 'wa': [4425]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2067811139', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-08T04:36:36.386585', 'created_date': '2016-06-24'}