Title: Coronary arterial dimension-to-left ventricular mass ratio in idiopathic dilated cardiomyopathy
Abstract: Several observations suggest that there is a direct relation between left ventricular (LV) mass and the cross-sectional area (CSA) of the proximal coronary arteries. 1 Roberts C.S. Roberts W.C. Cross-sectional area of the proximal portions of the three major epicardial coronary arteries in 98 necropsy patients with different coronary events. Relationship to heart weight, age and sex. Circulation. 1980; 62: 953-959 Crossref PubMed Scopus (96) Google Scholar , 2 O’Keefe J.H. Owen R.M. Bove A.A. Influence of left ventricular mass on coronary artery cross-sectional area. Am J Cardiol. 1987; 59: 1395-1397 Abstract Full Text PDF PubMed Scopus (57) Google Scholar , 3 Villary B. Hess O.M. Meier C. Pucillo A. Gaglione A. Turina M. Krayenbuehl H.P. Regression of coronary artery dimensions after successful aortic valve replacement. Circulation. 1992; 85: 972-978 Crossref PubMed Scopus (46) Google Scholar , 4 Nitenberg A. Antony I. Epicardial coronary arteries are not adequately sized in hypertensive patients. J Am Coll Cardiol. 1996; 27: 117-123 Abstract Full Text PDF Scopus (47) Google Scholar Increased coronary dimensions were demonstrated in patients with aortic valve disease, 1 Roberts C.S. Roberts W.C. Cross-sectional area of the proximal portions of the three major epicardial coronary arteries in 98 necropsy patients with different coronary events. Relationship to heart weight, age and sex. Circulation. 1980; 62: 953-959 Crossref PubMed Scopus (96) Google Scholar , 3 Villary B. Hess O.M. Meier C. Pucillo A. Gaglione A. Turina M. Krayenbuehl H.P. Regression of coronary artery dimensions after successful aortic valve replacement. Circulation. 1992; 85: 972-978 Crossref PubMed Scopus (46) Google Scholar , 5 Kaufmann P. Vassalli G. Lupi-Wagner S. Jenni R. Hess O. Coronary artery dimensions in primary and secondary left ventricular hypertrophy. J Am Coll Cardiol. 1996; 28: 745-750 Abstract Full Text PDF PubMed Google Scholar hypertensive heart disease, 4 Nitenberg A. Antony I. Epicardial coronary arteries are not adequately sized in hypertensive patients. J Am Coll Cardiol. 1996; 27: 117-123 Abstract Full Text PDF Scopus (47) Google Scholar and hypertrophic cardiomyopathy. 5 Kaufmann P. Vassalli G. Lupi-Wagner S. Jenni R. Hess O. Coronary artery dimensions in primary and secondary left ventricular hypertrophy. J Am Coll Cardiol. 1996; 28: 745-750 Abstract Full Text PDF PubMed Google Scholar This increase in coronary artery size is thought to represent an adaptive response to maintain coronary blood flow and shear stress constant. 6 Schachinger V. Zeiher A.M. Quantitative assessment of coronary vasoreactivity in humans in vivo. Importance of baseline vasomotor tone in atherosclerosis. Circulation. 1995; 92: 2087-2094 Crossref PubMed Scopus (90) Google Scholar , 7 Pol U. Holtz J. Busse R. Bassenge E. Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension. 1986; 8: 37-44 Crossref PubMed Scopus (770) Google Scholar Recent data suggest that the enlargement of coronary arteries in patients with pressure overload hypertrophy is inadequate for the degree of LV hypertrophy. 3 Villary B. Hess O.M. Meier C. Pucillo A. Gaglione A. Turina M. Krayenbuehl H.P. Regression of coronary artery dimensions after successful aortic valve replacement. Circulation. 1992; 85: 972-978 Crossref PubMed Scopus (46) Google Scholar Limited information is available about the relation between coronary dimensions and LV mass in patients with idiopathic dilated cardiomyopathy (IDC). This relation may be relevant because coronary vasodilatory reserve is decreased in this condition, 8 Treasure C.H. Vita J.A. Cox D.A. Fish R.D. Gordon J.B. Mudge G.H. Colucci W.S. St. John Sutton M.G. Selwyn A.P. Alexander R.W. Ganz P. Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy. Circulation. 1990; 81: 772-779 Crossref PubMed Scopus (401) Google Scholar , 9 Inoue T. Sakai Y. Morooka S. Hayashi T. Takayanagi K. Yamaguchi H. Kakoi H. Takabatake Y. Vasodilatory capacity of coronary resistance vessels in dilated cardiomyopathy. Am Heart J. 1994; 127: 376-381 Abstract Full Text PDF PubMed Scopus (67) Google Scholar , 10 Inoue T. Sakai Y. Morooka S. Hayashi T. Takayanagi K. Yamanaka T. Kakoi H. Takabatake Y. Coronary flow reserve in patients with dilated cardiomyopathy. Am Heart J. 1993; 125: 93-98 Abstract Full Text PDF PubMed Scopus (101) Google Scholar , 11 Weismuller S. Czernin J. Sun K.T. Fung C. Phelps M.E. Schelbert H.R. Coronary vasodilatory capacity is impaired in patients with dilated cardiomyopathy. Am J Card Imaging. 1996; 10: 154-162 PubMed Google Scholar and, if the coronary artery size is inappropriate for the LV mass, it may contribute to explaining the occurrence of myocardial ischemia during conditions when myocardial oxygen demand is increased. This study investigates the relation between coronary artery dimension and LV mass in patients with IDC.
Publication Year: 1999
Publication Date: 1999-04-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 13
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