Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2066700975', 'doi': 'https://doi.org/10.1158/1538-7445.am2013-5187', 'title': 'Abstract 5187: The membrane traffic regulator PACS-1 mediates genome stability at S-phase of the cell cycle.', 'display_name': 'Abstract 5187: The membrane traffic regulator PACS-1 mediates genome stability at S-phase of the cell cycle.', 'publication_year': 2013, 'publication_date': '2013-04-01', 'ids': {'openalex': 'https://openalex.org/W2066700975', 'doi': 'https://doi.org/10.1158/1538-7445.am2013-5187', 'mag': '2066700975'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2013-5187', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051921134', 'display_name': 'Mysore S. Veena', 'orcid': 'https://orcid.org/0009-0008-3168-8027'}, 'institutions': [{'id': 'https://openalex.org/I4210156876', 'display_name': 'VA Greater Los Angeles Healthcare System', 'ror': 'https://ror.org/05xcarb80', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210138663', 'https://openalex.org/I4210156876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mysore S. Veena', 'raw_affiliation_strings': ['1VA Greater Los Angeles Healthcare System, Los Angeles, CA;'], 'affiliations': [{'raw_affiliation_string': '1VA Greater Los Angeles Healthcare System, Los Angeles, CA;', 'institution_ids': ['https://openalex.org/I4210156876']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112904701', 'display_name': 'Saroj K. Basak', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210156876', 'display_name': 'VA Greater Los Angeles Healthcare System', 'ror': 'https://ror.org/05xcarb80', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210138663', 'https://openalex.org/I4210156876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Saroj K. Basak', 'raw_affiliation_strings': ['1VA Greater Los Angeles Healthcare System, Los Angeles, CA;'], 'affiliations': [{'raw_affiliation_string': '1VA Greater Los Angeles Healthcare System, Los Angeles, CA;', 'institution_ids': ['https://openalex.org/I4210156876']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001426056', 'display_name': 'Natarajan Venkatesan', 'orcid': 'https://orcid.org/0009-0008-1030-1532'}, 'institutions': [{'id': 'https://openalex.org/I4210156876', 'display_name': 'VA Greater Los Angeles Healthcare System', 'ror': 'https://ror.org/05xcarb80', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210138663', 'https://openalex.org/I4210156876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Natarajan Venkatesan', 'raw_affiliation_strings': ['1VA Greater Los Angeles Healthcare System, Los Angeles, CA;'], 'affiliations': [{'raw_affiliation_string': '1VA Greater Los Angeles Healthcare System, Los Angeles, CA;', 'institution_ids': ['https://openalex.org/I4210156876']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029799210', 'display_name': 'Alborz Zinabadi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210156876', 'display_name': 'VA Greater Los Angeles Healthcare System', 'ror': 'https://ror.org/05xcarb80', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210138663', 'https://openalex.org/I4210156876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alborz Zinabadi', 'raw_affiliation_strings': ['1VA Greater Los Angeles Healthcare System, Los Angeles, CA;'], 'affiliations': [{'raw_affiliation_string': '1VA Greater Los Angeles Healthcare System, Los Angeles, CA;', 'institution_ids': ['https://openalex.org/I4210156876']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110129104', 'display_name': 'Laurel Thomas', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laurel Thomas', 'raw_affiliation_strings': ['2University of Pittsburgh School of Medicine, Pittsburgh, PA.'], 'affiliations': [{'raw_affiliation_string': '2University of Pittsburgh School of Medicine, Pittsburgh, PA.', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030103232', 'display_name': 'Gary Thomas', 'orcid': 'https://orcid.org/0000-0003-1976-7183'}, 'institutions': [{'id': 'https://openalex.org/I170201317', 'display_name': 'University of Pittsburgh', 'ror': 'https://ror.org/01an3r305', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I170201317']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gary Thomas', 'raw_affiliation_strings': ['2University of Pittsburgh School of Medicine, Pittsburgh, PA.'], 'affiliations': [{'raw_affiliation_string': '2University of Pittsburgh School of Medicine, Pittsburgh, PA.', 'institution_ids': ['https://openalex.org/I170201317']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064974770', 'display_name': 'Eri S. Srivatsan', 'orcid': 'https://orcid.org/0000-0001-5551-8163'}, 'institutions': [{'id': 'https://openalex.org/I4210156876', 'display_name': 'VA Greater Los Angeles Healthcare System', 'ror': 'https://ror.org/05xcarb80', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1322918889', 'https://openalex.org/I2799886695', 'https://openalex.org/I4210138663', 'https://openalex.org/I4210156876']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eri S. Srivatsan', 'raw_affiliation_strings': ['1VA Greater Los Angeles Healthcare System, Los Angeles, CA;'], 'affiliations': [{'raw_affiliation_string': '1VA Greater Los Angeles Healthcare System, Los Angeles, CA;', 'institution_ids': ['https://openalex.org/I4210156876']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 65}, 'biblio': {'volume': '73', 'issue': '8_Supplement', 'first_page': '5187', 'last_page': '5187'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9816, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9816, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10515', 'display_name': 'Cancer-related molecular mechanisms research', 'score': 0.9752, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11297', 'display_name': 'Ferroptosis and cancer prognosis', 'score': 0.9643, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hela', 'display_name': 'HeLa', 'score': 0.46425062}], 'concepts': [{'id': 'https://openalex.org/C173396325', 'wikidata': 'https://www.wikidata.org/wiki/Q1501275', 'display_name': 'Gene knockdown', 'level': 3, 'score': 0.7148235}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.66254514}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.5231075}, {'id': 'https://openalex.org/C2777366897', 'wikidata': 'https://www.wikidata.org/wiki/Q847482', 'display_name': 'HeLa', 'level': 3, 'score': 0.46425062}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.45433953}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45412958}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.44920364}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.43465438}, {'id': 'https://openalex.org/C6929976', 'wikidata': 'https://www.wikidata.org/wiki/Q3771881', 'display_name': 'Regulator', 'level': 3, 'score': 0.4340644}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.42167416}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.40570992}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.36538237}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.32393}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.27143216}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2013-5187', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.6}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3103789129', 'https://openalex.org/W2386797884', 'https://openalex.org/W2375824005', 'https://openalex.org/W2373307992', 'https://openalex.org/W2372231441', 'https://openalex.org/W2357943637', 'https://openalex.org/W2352662618', 'https://openalex.org/W2352284239', 'https://openalex.org/W2350526420', 'https://openalex.org/W2319590788'], 'abstract_inverted_index': {'Abstract': [0], 'We': [1, 228], 'previously': [2], 'mapped': [3], 'a': [4, 29, 57, 78, 224], '5.5': [5], 'kb': [6], 'homozygous': [7], 'deletion': [8, 34, 112], 'in': [9, 43, 62, 66, 96, 150, 220, 223, 235, 240], 'cervical': [10, 45, 67, 97, 236], 'cancer': [11, 68, 98, 237], 'cell': [12, 69, 85, 99, 127, 130, 284], 'lines': [13, 100], 'and': [14, 101, 118, 129, 153, 192, 209, 243], 'primary': [15, 44, 102], 'tumors': [16, 46, 103], 'to': [17, 48, 114, 148, 195, 250], 'chromosome': [18], '11q13': [19], 'within': [20], 'the': [21, 54, 63, 73, 110, 120, 177, 190, 193, 203, 221, 241, 283, 290, 295], '1st': [22], 'intron': [23], 'of': [24, 39, 56, 72, 107, 123, 139, 144, 156, 161, 165, 179, 233, 245, 282, 289, 294], 'PACS-1': [25, 42, 74, 116, 124, 140, 162, 172, 180, 186, 204, 218, 234, 276], 'gene,': [26], 'which': [27, 83], 'encodes': [28], 'membrane': [30, 273], 'traffic': [31, 274], 'regulator.': [32], 'This': [33], 'correlates': [35], 'with': [36, 134, 200], 'elevated': [37], 'expression': [38, 55, 93, 117, 122, 143, 155, 164, 181, 232], '120': [40], 'kDa': [41, 59], 'compared': [47], 'normal': [49], 'tissues': [50], 'as': [51, 53], 'well': [52], '140': [58], 'immunoreactive': [60], 'isoform': [61], 'nucleus': [64, 194, 222], 'specifically': [65], 'lines.': [70], 'Inspection': [71], 'mRNA': [75], 'sequence': [76, 205], 'revealed': [77, 216], 'target': [79], 'site': [80], 'for': [81, 298], 'miR449a,': [82], 'mediates': [84, 173, 277], 'fate.': [86], 'Northern': [87], 'blot': [88], 'analysis': [89], 'showed': [90], 'miRNA': [91], '449a': [92, 167], 'was': [94], 'reduced': [95, 168], 'suggesting': [104], 'that': [105, 119, 230], 'dysregulation': [106], 'miRNA449a': [108], 'or': [109, 141, 163], 'intronic': [111], 'contributed': [113], 'aberrant': [115, 231], 'increased': [121, 142], 'may': [125], 'mediate': [126, 196], 'viability': [128], 'cycle': [131], 'progression.': [132], 'Consistent': [133, 199], 'this': [135, 201], 'possibility,': [136, 202], 'siRNA': [137], 'knockdown': [138], 'miR449a': [145], 'caused': [146], 'cells': [147, 238], 'accumulate': [149], 'S': [151], 'phase': [152], 'induced': [154], 'γH2AX.': [157], 'By': [158], 'contrast,': [159], 'overexpression': [160], 'antimiR': [166], 'γH2AX': [169], 'expression.': [170], 'Whereas': [171], 'secretory': [174], 'pathway': [175], 'trafficking,': [176], 'effect': [178], 'on': [182], 'genome': [183, 197, 278], 'stability': [184, 279], 'suggested': [185], 'might': [187], 'shuttle': [188], 'between': [189], 'cytoplasm': [191], 'stability.': [198], 'contains': [206], 'canonical': [207], 'NLS': [208], 'NES': [210], 'motifs.': [211], 'Indeed,': [212], 'confocal': [213], 'microscopy': [214], 'studies': [215], 'GFP-tagged': [217], 'accumulated': [219], 'leptomycin': [225], 'B-dependent': [226], 'manner.': [227], 'hypothesize': [229], 'results': [239], 'stabilization': [242], 'replication': [244], 'rearranged': [246], 'DNA': [247], 'sequences': [248], 'leading': [249], 'tumor': [251], 'development.': [252], 'Citation': [253], 'Format:': [254], 'Mysore': [255], 'S.': [256, 270], 'Veena,': [257], 'Saroj': [258], 'K.': [259], 'Basak,': [260], 'Natarajan': [261], 'Venkatesan,': [262], 'Alborz': [263], 'Zinabadi,': [264], 'Laurel': [265], 'Thomas,': [266, 268], 'Gary': [267], 'Eri': [269], 'Srivatsan.': [271], 'The': [272], 'regulator': [275], 'at': [280], 'S-phase': [281], 'cycle.': [285], '[abstract].': [286], 'In:': [287], 'Proceedings': [288], '104th': [291], 'Annual': [292], 'Meeting': [293], 'American': [296], 'Association': [297], 'Cancer': [299, 309], 'Research;': [300], '2013': [301], 'Apr': [302], '6-10;': [303], 'Washington,': [304], 'DC.': [305], 'Philadelphia': [306], '(PA):': [307], 'AACR;': [308], 'Res': [310], '2013;73(8': [311], 'Suppl):Abstract': [312], 'nr': [313], '5187.': [314], 'doi:10.1158/1538-7445.AM2013-5187': [315]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2066700975', 'counts_by_year': [], 'updated_date': '2024-12-08T17:32:40.903919', 'created_date': '2016-06-24'}