Title: Analysis of osmotic hemolysis of erythrocytes including mechanical and transport effects
Abstract: Although the osmotic fragility test is frequently used to ascertain red blood cell pathology, the relationship that this measurement bears to the transport properties and mechanics of the membrane is poorly understood. An analysis of osmotic red blood cell swelling has been developed that considers the effect of tangential membrane stresses generated by the water transport. This analysis has been applied to the existing data from gradual hemolysis and osmotic fragility experiments by employing a three-parameter equation to describe membrane mechanics and by assuming that hemolysis occurs at a critical recoverable membrane energy. The analysis is consistent with the data of these experiments and the results indicate that membrane permeability does not affect the outcome of the gradual osmotic hemolysis experiment, but has a crucial effect on the osmotic fragility experiment.
Publication Year: 1972
Publication Date: 1972-04-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 1
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