Growth Arrest-specific Gene 6 Is Involved in Glomerular Hypertrophy in the Early Stage of Diabetic Nephropathy

Name: Work Video:
Duration: 3 min 30 s
Kojiro Nagai; Hidenori Arai; Motoko Yanagita; Takeshi Matsubara; Hiroshi Kanamori; Toru Nakano; Noriyuki Iehara; Atsushi Fukatsu; Toru Kita; Toshio Doi
{'id': 'https://openalex.org/W2064741730', 'doi': 'https://doi.org/10.1074/jbc.m213266200', 'title': 'Growth Arrest-specific Gene 6 Is Involved in Glomerular Hypertrophy in the Early Stage of Diabetic Nephropathy', 'display_name': 'Growth Arrest-specific Gene 6 Is Involved in Glomerular Hypertrophy in the Early Stage of Diabetic Nephropathy', 'publication_year': 2003, 'publication_date': '2003-05-01', 'ids': {'openalex': 'https://openalex.org/W2064741730', 'doi': 'https://doi.org/10.1074/jbc.m213266200', 'mag': '2064741730', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12644472'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m213266200', 'pdf_url': 'http://www.jbc.org/article/S0021925819549213/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819549213/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071091023', 'display_name': 'Kojiro Nagai', 'orcid': 'https://orcid.org/0000-0002-8348-2855'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kojiro Nagai', 'raw_affiliation_strings': ['Departments of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan'], 'affiliations': [{'raw_affiliation_string': 'Departments of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076061467', 'display_name': 'Hidenori Arai', 'orcid': 'https://orcid.org/0000-0002-9000-6849'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hidenori Arai', 'raw_affiliation_strings': ['Departments of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan'], 'affiliations': [{'raw_affiliation_string': 'Departments of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053240410', 'display_name': 'Motoko Yanagita', 'orcid': 'https://orcid.org/0000-0002-0339-9008'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Motoko Yanagita', 'raw_affiliation_strings': ['Departments of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan'], 'affiliations': [{'raw_affiliation_string': 'Departments of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033052103', 'display_name': 'Takeshi Matsubara', 'orcid': 'https://orcid.org/0000-0002-2380-1551'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Takeshi Matsubara', 'raw_affiliation_strings': ['Departments of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan'], 'affiliations': [{'raw_affiliation_string': 'Departments of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026761290', 'display_name': 'Hiroshi Kanamori', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hiroshi Kanamori', 'raw_affiliation_strings': ['Departments of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan'], 'affiliations': [{'raw_affiliation_string': 'Departments of Geriatric Medicine, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044707863', 'display_name': 'Toru Nakano', 'orcid': 'https://orcid.org/0000-0003-1824-9122'}, 'institutions': [{'id': 'https://openalex.org/I88302906', 'display_name': 'Futaba (Japan)', 'ror': 'https://ror.org/03b6zzt23', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I88302906']}, {'id': 'https://openalex.org/I4210118477', 'display_name': 'Shionogi (Japan)', 'ror': 'https://ror.org/01v3bqg10', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210118477']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toru Nakano', 'raw_affiliation_strings': ['Discovery Research Laboratory, Shionogi Co., Ltd., Osaka 553-0002, Japan'], 'affiliations': [{'raw_affiliation_string': 'Discovery Research Laboratory, Shionogi Co., Ltd., Osaka 553-0002, Japan', 'institution_ids': ['https://openalex.org/I88302906', 'https://openalex.org/I4210118477']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019170168', 'display_name': 'Noriyuki Iehara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Noriyuki Iehara', 'raw_affiliation_strings': ['Departments of Artificial Kidneys, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan'], 'affiliations': [{'raw_affiliation_string': 'Departments of Artificial Kidneys, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110394383', 'display_name': 'Atsushi Fukatsu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Atsushi Fukatsu', 'raw_affiliation_strings': ['Departments of Artificial Kidneys, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan'], 'affiliations': [{'raw_affiliation_string': 'Departments of Artificial Kidneys, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109115866', 'display_name': 'Toru Kita', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toru Kita', 'raw_affiliation_strings': ['Departments of Cardiovascular Medicine, and Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan'], 'affiliations': [{'raw_affiliation_string': 'Departments of Cardiovascular Medicine, and Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103143734', 'display_name': 'Toshio Doi', 'orcid': 'https://orcid.org/0000-0002-4415-2474'}, 'institutions': [{'id': 'https://openalex.org/I922474255', 'display_name': 'Tokushima University', 'ror': 'https://ror.org/044vy1d05', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I922474255']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Toshio Doi', 'raw_affiliation_strings': ['Department of Clinical Biology and Medicine, Tokushima University, Tokushima 770-8503, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Biology and Medicine, Tokushima University, Tokushima 770-8503, Japan', 'institution_ids': ['https://openalex.org/I922474255']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 2.421, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 105, 'citation_normalized_percentile': {'value': 0.893693, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '278', 'issue': '20', 'first_page': '18229', 'last_page': '18234'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12672', 'display_name': 'Phagocytosis and Immune Regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12672', 'display_name': 'Phagocytosis and Immune Regulation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11193', 'display_name': 'Adenosine and Purinergic Signaling', 'score': 0.9746, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/renal-hypertrophy', 'display_name': 'Renal Hypertrophy', 'score': 0.682955}, {'id': 'https://openalex.org/keywords/gas6', 'display_name': 'GAS6', 'score': 0.6241633}, {'id': 'https://openalex.org/keywords/albuminuria', 'display_name': 'Albuminuria', 'score': 0.57256126}, {'id': 'https://openalex.org/keywords/mesangial-cell', 'display_name': 'Mesangial cell', 'score': 0.44289932}], 'concepts': [{'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.7204534}, {'id': 'https://openalex.org/C2909763481', 'wikidata': 'https://www.wikidata.org/wiki/Q1054718', 'display_name': 'Renal Hypertrophy', 'level': 4, 'score': 0.682955}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.6668034}, {'id': 'https://openalex.org/C172811965', 'wikidata': 'https://www.wikidata.org/wiki/Q21110911', 'display_name': 'GAS6', 'level': 4, 'score': 0.6241633}, {'id': 'https://openalex.org/C2779922275', 'wikidata': 'https://www.wikidata.org/wiki/Q1129105', 'display_name': 'Diabetic nephropathy', 'level': 3, 'score': 0.62004125}, {'id': 'https://openalex.org/C2776174234', 'wikidata': 'https://www.wikidata.org/wiki/Q974792', 'display_name': 'Albuminuria', 'level': 3, 'score': 0.57256126}, {'id': 'https://openalex.org/C2781184683', 'wikidata': 'https://www.wikidata.org/wiki/Q1054718', 'display_name': 'Nephropathy', 'level': 3, 'score': 0.5699854}, {'id': 'https://openalex.org/C167414201', 'wikidata': 'https://www.wikidata.org/wiki/Q1955391', 'display_name': 'Muscle hypertrophy', 'level': 2, 'score': 0.56043404}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.55642784}, {'id': 'https://openalex.org/C2779131090', 'wikidata': 'https://www.wikidata.org/wiki/Q3331086', 'display_name': 'Mesangial cell', 'level': 3, 'score': 0.44289932}, {'id': 'https://openalex.org/C159641895', 'wikidata': 'https://www.wikidata.org/wiki/Q108377937', 'display_name': 'Renal function', 'level': 2, 'score': 0.4151672}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.37495565}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.35209322}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.14396483}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.048570126}], 'mesh': [{'descriptor_ui': 'D003928', 'descriptor_name': 'Diabetic Nephropathies', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006984', 'descriptor_name': 'Hypertrophy', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000419', 'descriptor_name': 'Albuminuria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003928', 'descriptor_name': 'Diabetic Nephropathies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005434', 'descriptor_name': 'Flow Cytometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005919', 'descriptor_name': 'Glomerular Filtration Rate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006984', 'descriptor_name': 'Hypertrophy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007674', 'descriptor_name': 'Kidney Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007930', 'descriptor_name': 'Leucine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D007930', 'descriptor_name': 'Leucine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019950', 'descriptor_name': 'Mitogen-Activated Protein Kinase 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019950', 'descriptor_name': 'Mitogen-Activated Protein Kinase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048052', 'descriptor_name': 'Mitogen-Activated Protein Kinase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020928', 'descriptor_name': 'Mitogen-Activated Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015513', 'descriptor_name': 'Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015513', 'descriptor_name': 'Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020794', 'descriptor_name': 'Receptor Protein-Tyrosine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053773', 'descriptor_name': 'Transforming Growth Factor beta1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014859', 'descriptor_name': 'Warfarin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014859', 'descriptor_name': 'Warfarin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m213266200', 'pdf_url': 'http://www.jbc.org/article/S0021925819549213/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/2433/147472', 'pdf_url': 'https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/147472/1/yigak02694.pdf', 'source': {'id': 'https://openalex.org/S4306401454', 'display_name': 'Kyoto University Research Information Repository (Kyoto University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I22299242', 'host_organization_name': 'Kyoto University', 'host_organization_lineage': ['https://openalex.org/I22299242'], 'host_organization_lineage_names': ['Kyoto University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12644472', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m213266200', 'pdf_url': 'http://www.jbc.org/article/S0021925819549213/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.81, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 36, 'referenced_works': ['https://openalex.org/W1530473805', 'https://openalex.org/W1954516783', 'https://openalex.org/W1963864987', 'https://openalex.org/W1982173050', 'https://openalex.org/W1986454739', 'https://openalex.org/W2000519471', 'https://openalex.org/W2005431362', 'https://openalex.org/W2030811113', 'https://openalex.org/W2040961193', 'https://openalex.org/W2044102243', 'https://openalex.org/W2044502131', 'https://openalex.org/W2045062962', 'https://openalex.org/W2045926020', 'https://openalex.org/W2049040427', 'https://openalex.org/W2050332600', 'https://openalex.org/W2064788684', 'https://openalex.org/W2064927835', 'https://openalex.org/W2069387668', 'https://openalex.org/W2072039186', 'https://openalex.org/W2091552383', 'https://openalex.org/W2092661802', 'https://openalex.org/W2096405472', 'https://openalex.org/W2099088745', 'https://openalex.org/W2126433244', 'https://openalex.org/W2130791906', 'https://openalex.org/W2137108685', 'https://openalex.org/W2152252443', 'https://openalex.org/W2159186386', 'https://openalex.org/W2165868580', 'https://openalex.org/W2166247105', 'https://openalex.org/W2168279537', 'https://openalex.org/W2325331917', 'https://openalex.org/W2337548499', 'https://openalex.org/W2340025308', 'https://openalex.org/W3058535', 'https://openalex.org/W4232719248'], 'related_works': ['https://openalex.org/W2387690328', 'https://openalex.org/W2157781136', 'https://openalex.org/W2113839433', 'https://openalex.org/W2095477008', 'https://openalex.org/W2064788684', 'https://openalex.org/W2051049950', 'https://openalex.org/W2039629622', 'https://openalex.org/W2020479094', 'https://openalex.org/W1980807338', 'https://openalex.org/W1889397865'], 'abstract_inverted_index': {'Nephropathy': [0, 196], 'is': [1, 13, 197, 209, 402, 492, 514, 545, 748, 831, 960, 966, 1007, 2793, 2860, 2897, 2919, 2931, 3136, 3167, 3229, 3268, 3285, 3354, 3557, 3579, 3672, 3831, 4287, 4330, 4444, 4525, 4626, 4886, 4979, 5012, 5021, 5201, 5227], 'one': [2, 198, 2794, 3700, 4331], 'of': [3, 8, 20, 25, 52, 60, 65, 94, 100, 110, 147, 164, 174, 178, 193, 199, 204, 216, 221, 248, 256, 261, 290, 296, 306, 343, 360, 370, 374, 389, 407, 417, 478, 489, 509, 552, 606, 648, 712, 721, 753, 763, 853, 863, 872, 881, 953, 979, 1015, 1021, 1029, 1084, 1146, 1150, 1153, 1168, 1279, 1332, 1359, 1375, 1384, 1393, 1519, 1524, 1578, 1590, 1615, 1768, 1815, 1850, 1872, 2210, 2234, 2244, 2376, 2393, 2419, 2429, 2435, 2453, 2460, 2486, 2506, 2513, 2548, 2590, 2608, 2625, 2639, 2665, 2795, 2819, 2827, 2841, 2846, 2855, 2905, 2915, 2923, 2946, 2973, 2997, 3019, 3124, 3141, 3145, 3197, 3205, 3211, 3225, 3233, 3258, 3281, 3290, 3294, 3303, 3337, 3350, 3366, 3385, 3407, 3467, 3484, 3489, 3495, 3499, 3502, 3523, 3547, 3569, 3573, 3585, 3607, 3611, 3621, 3701, 3710, 3781, 3798, 3820, 3827, 3859, 3896, 3901, 3910, 3913, 4046, 4055, 4140, 4154, 4164, 4184, 4311, 4322, 4332, 4391, 4408, 4434, 4467, 4483, 4490, 4530, 4536, 4646, 4828, 4913, 4983, 5030, 5053, 5066, 5115, 5154, 5165, 5184, 5214, 5218, 5235, 5248, 5265], 'the': [4, 17, 21, 50, 57, 63, 82, 118, 168, 172, 179, 191, 200, 213, 217, 246, 253, 259, 278, 314, 364, 368, 375, 387, 403, 475, 518, 523, 549, 553, 604, 646, 710, 719, 761, 769, 851, 860, 873, 951, 977, 1012, 1022, 1027, 1085, 1143, 1154, 1165, 1197, 1460, 1517, 1530, 1576, 1596, 1712, 1771, 1816, 1862, 1881, 1947, 1987, 2094, 2097, 2121, 2155, 2179, 2203, 2218, 2232, 2247, 2276, 2303, 2363, 2384, 2427, 2432, 2448, 2469, 2495, 2504, 2510, 2514, 2567, 2602, 2605, 2632, 2663, 2691, 2694, 2765, 2778, 2796, 2817, 2844, 2872, 2885, 2912, 2958, 2971, 2976, 3049, 3055, 3058, 3065, 3122, 3139, 3142, 3157, 3162, 3254, 3272, 3277, 3291, 3304, 3325, 3340, 3348, 3357, 3363, 3373, 3386, 3395, 3422, 3519, 3558, 3570, 3583, 3605, 3608, 3677, 3682, 3696, 3702, 3707, 3796, 3817, 3835, 3893, 3899, 3904, 3908, 3911, 3926, 3961, 4053, 4092, 4182, 4294, 4309, 4317, 4333, 4385, 4432, 4448, 4453, 4528, 4533, 4560, 4587, 4617, 4883, 4895, 4906, 4911, 4921, 4980, 5028, 5034, 5048, 5061, 5064, 5152, 5176, 5202, 5212, 5215, 5233, 5246], 'most': [5, 201, 404, 2922], 'common': [6, 202, 405], 'complications': [7, 203], 'diabetes': [9, 205, 512, 4439], 'mellitus.': [10, 206], 'Glomerular': [11, 207], 'hypertrophy': [12, 77, 116, 132, 166, 208, 273, 312, 328, 362, 572, 2406, 2792, 2991, 3008, 3171, 3183, 3199, 3267, 3353, 3549, 3567, 3644, 3885, 4329, 4876, 4892, 4978, 5112, 5161, 5177, 5187], 'a': [14, 46, 161, 210, 242, 357, 502, 847, 877, 1008, 1081, 1328, 1960, 2258, 2348, 2501, 3195, 3216, 3286, 3458, 3544, 3595, 3601, 3618, 4138, 4151, 4389, 4399, 4487, 4565, 4577, 4627, 4638, 4758, 4821, 5173, 5228], 'hallmark': [15, 211], 'in': [16, 49, 62, 81, 106, 120, 124, 133, 153, 171, 182, 212, 245, 258, 277, 302, 316, 320, 329, 349, 367, 378, 412, 504, 511, 522, 568, 603, 655, 718, 760, 850, 876, 957, 985, 1002, 1011, 1032, 1159, 1274, 1338, 1364, 1513, 1686, 1689, 1824, 1959, 2089, 2154, 2173, 2183, 2252, 2295, 2329, 2410, 2422, 2431, 2438, 2468, 2492, 2503, 2509, 2528, 2539, 2544, 2550, 2600, 2615, 2650, 2670, 2717, 2755, 2769, 2777, 2781, 2800, 2811, 2866, 2876, 2884, 2921, 2933, 3000, 3009, 3024, 3039, 3044, 3071, 3090, 3101, 3111, 3117, 3138, 3169, 3172, 3184, 3190, 3242, 3249, 3313, 3417, 3443, 3550, 3604, 3640, 3685, 3864, 3920, 3929, 4031, 4058, 4064, 4186, 4189, 4336, 4388, 4438, 4452, 4470, 4486, 4492, 4522, 4532, 4616, 4641, 4648, 4864, 4877, 4880, 4898, 4910, 4927, 4994, 5008, 5026, 5033, 5047, 5080, 5158, 5178, 5188, 5195, 5211, 5250], 'early': [18, 214, 519, 550, 1013, 2433, 2511, 2863, 2913, 3571, 4449], 'phase': [19, 215, 1014, 2434, 2512, 2914, 3144, 3610, 4489, 4535, 5217], 'nephropathy.': [22, 176, 195, 218, 372, 391, 698, 2533, 3587, 3613, 3687, 4410, 4985, 5010, 5180, 5237], 'The': [23, 97, 219, 293, 486, 507, 963, 1134, 1177, 1382, 1468, 1494, 1522, 1813, 1891, 1936, 1953, 1982, 2151, 2197, 2267, 2298, 2358, 2574, 3222, 3246, 3335, 3411, 3463, 3507, 3516, 3856, 4320, 4548, 5181], 'mechanism': [24, 163, 220, 359, 477, 3163, 3546, 3651, 5183, 5231], 'glomerular': [26, 67, 76, 83, 98, 115, 165, 222, 263, 272, 279, 294, 311, 361, 396, 524, 705, 981, 1178, 1983, 2405, 2637, 2757, 2779, 2791, 2808, 2822, 2849, 2899, 2990, 3007, 3098, 3170, 4026, 4454, 4922, 4975], 'hypertrophy,': [27, 223, 1005], 'however,': [28, 224, 4459], 'remains': [29, 225, 3906, 4987], 'incompletely': [30, 226], 'understood.': [31, 227], 'We': [32, 228, 2446, 2534, 3186, 3381, 3915, 4620, 5037, 5253, 5271], 'have': [33, 159, 229, 355, 470, 558, 708, 2708, 3542, 3616, 3791, 3891, 3916, 3964, 4479, 4621, 4749, 4868, 5038, 5146], 'reported': [34, 230, 4063, 4136, 4173, 4480, 4966], 'that': [35, 145, 231, 341, 829, 840, 857, 2404, 2458, 2473, 2662, 2693, 2710, 2895, 2989, 3134, 3150, 3257, 3347, 3383, 3561, 3577, 3591, 3599, 3631, 3675, 3919, 4022, 4043, 4137, 4174, 4290, 4431, 4624, 4635, 4751, 4871, 4920, 4967, 5014, 5041, 5057, 5205], 'Gas6': [36, 101, 135, 151, 232, 297, 331, 347, 713, 830, 841, 954, 971, 994, 1075, 1086, 1721, 2462, 2487, 2640, 2684, 2711, 2982, 3010, 3026, 3040, 3073, 3119, 3135, 3166, 3178, 3208, 3234, 3319, 3351, 3389, 3562, 3592, 4141, 4185, 4306, 4531, 4551, 4625, 4636, 4752, 4872, 4888, 4990, 5002, 5206], '(growth': [37, 233, 714], 'arrest-specific': [38, 234, 715], 'gene': [39, 235, 716, 1087], '6)': [40, 236, 717], 'and': [41, 75, 78, 87, 102, 114, 117, 122, 237, 271, 274, 283, 298, 310, 313, 318, 495, 501, 565, 595, 766, 839, 842, 859, 955, 972, 984, 995, 1018, 1036, 1164, 1192, 1272, 1309, 1370, 1397, 1399, 1462, 1466, 1488, 1600, 1612, 1670, 1700, 1749, 1852, 1946, 1986, 2105, 2108, 2116, 2231, 2255, 2279, 2326, 2407, 2412, 2456, 2463, 2472, 2480, 2488, 2557, 2577, 2634, 2641, 2759, 2784, 2807, 2815, 2839, 2848, 2891, 2936, 2950, 2957, 2961, 3006, 3012, 3035, 3097, 3148, 3296, 3329, 3440, 3576, 3636, 3645, 3652, 3733, 3770, 3871, 4020, 4025, 4156, 4188, 4297, 4405, 4552, 4612, 4634, 4643, 4820, 4826, 4879, 4997, 5000, 5056, 5110, 5124, 5207, 5260, 5278], 'its': [42, 238, 757, 843, 3786, 5077], 'receptor,': [43, 239], 'Axl,': [44, 240, 1901], 'play': [45, 241, 846, 998, 2500], 'key': [47, 243, 4639], 'role': [48, 59, 244, 255, 711, 849, 952, 1001, 2428, 2502, 3603, 4529, 4640, 5025, 5153], 'development': [51, 173, 247, 369, 508, 605, 852, 2505, 3140, 3606, 3900, 4310, 4433, 5213, 5234], 'glomerulonephritis.': [53, 249], 'Here': [54, 250, 3614], 'we': [55, 128, 143, 158, 251, 324, 339, 354, 707, 827, 990, 2440, 2518, 2612, 2628, 2654, 2660, 2707, 2746, 2803, 2869, 2927, 2979, 3003, 3175, 3275, 3361, 3541, 3615, 3716, 3890, 3963, 4040, 4149, 4160, 4171, 4460, 4539, 4748, 4867, 4904, 4916, 5145], 'show': [56, 252, 3630], 'important': [58, 254, 546, 1000], 'Gas6/Axl': [61, 180, 257, 376, 1023, 2430, 2496, 2977, 3678, 3927], 'pathogenesis': [64, 260, 720, 978], 'diabetic': [66, 72, 175, 183, 194, 262, 268, 371, 379, 390, 420, 424, 479, 490, 607, 650, 658, 697, 958, 980, 1016, 1030, 1326, 1352, 1412, 1484, 1489, 1570, 2436, 2443, 2493, 2507, 2532, 2756, 2801, 2812, 2867, 2892, 2916, 2924, 3072, 3078, 3102, 3118, 3146, 3153, 3173, 3551, 3574, 3586, 3612, 3686, 3690, 3718, 3902, 4065, 4312, 4337, 4409, 4537, 4553, 4900, 4914, 4928, 4968, 4984, 4998, 5009, 5179, 5189, 5219, 5236, 5251], 'hypertrophy.': [68, 156, 264, 352, 2823, 5225], 'In': [69, 141, 265, 337, 987, 2911, 3538, 4146, 4456, 4745, 5063, 5198], 'streptozotocin': [70, 266, 395, 1033], '(STZ)-induced': [71, 267], 'rats,': [73, 269, 2494, 2783, 2838, 3174, 4915], 'mesangial': [74, 113, 131, 148, 154, 270, 309, 327, 344, 350, 496, 569, 837, 866, 878, 1003, 1179, 1255, 1954, 1977, 2309, 2338, 2481, 2805, 2847, 2856, 3005, 3095, 3181, 3192, 3244, 3265, 3327, 3367, 3408, 3423, 3448, 3503, 3548, 3565, 3883, 3921, 4024, 4327, 4403, 4631, 4755, 4875, 4891, 4896, 4907, 5031, 5159, 5185, 5223], 'an': [79, 275, 483, 832, 999, 1373, 1994, 2408, 2572, 2862, 3230, 3301, 3624, 3649, 3728, 3840, 4464, 5023], 'increase': [80, 119, 276, 315, 2409, 2845, 3123, 3218, 3248, 4321], 'filtration': [84, 280, 397], 'rate': [85, 281, 398], '(GFR)': [86, 282], 'albuminuria': [88, 123, 284, 319, 494, 2413, 2962], 'were': [89, 285, 1066, 1078, 1126, 1136, 1157, 1261, 1324, 1350, 1378, 1387, 1409, 1464, 1470, 1499, 1598, 1617, 1672, 1683, 1705, 1763, 1822, 1864, 1883, 1893, 1939, 1980, 1991, 2072, 2099, 2114, 2167, 2181, 2220, 2249, 2269, 2288, 2300, 2311, 2340, 2414, 2475, 2553, 2563, 2582, 2832, 2954, 2963, 3029, 3053, 3106, 3413, 3425, 3450, 3867, 4028], 'observed': [90, 286, 2415, 2599, 2993, 3878], 'after': [91, 287, 1391, 1457, 1588, 1594, 2416, 2450, 2902, 2994, 3016, 3200, 3505, 4545, 5050], '12': [92, 288, 2080, 2417, 2451, 2623, 2825, 2903, 2944, 2995, 3017, 4474, 4543, 5051], 'weeks': [93, 289, 1456, 1593, 2081, 2418, 2452, 2624, 2826, 2904, 2945, 2996, 3018, 4544, 5052], 'STZ': [95, 125, 291, 321, 1038, 1333, 1360, 1394, 1458, 1520, 2420, 2454, 2626, 2656, 2672, 2676, 2782, 2828, 2906, 2934, 2947, 2998, 3020, 3641, 4000, 4471, 4493, 4546, 4574, 5054], 'injection.': [96, 292, 1521, 3021, 4547], 'expression': [99, 295, 2459, 2485, 2638, 2664], 'Axl': [103, 299, 845, 864, 956, 973, 996, 1751, 2464, 2489, 2642, 2666, 3282, 3295, 4761, 5208], 'was': [104, 300, 1039, 1052, 1182, 1193, 1526, 1580, 1603, 1658, 1818, 1875, 1957, 2077, 2118, 2157, 2199, 2239, 2371, 2395, 2465, 2490, 2597, 2667, 2775, 2881, 2992, 3037, 3069, 3083, 3127, 3252, 3322, 3332, 3822, 3877, 3886, 4925, 5045], 'increased': [105, 301, 2467, 2636, 2920, 2932, 2959, 3209, 3341, 3394, 4481, 4926], 'those': [107, 303, 3110, 4746], 'rats.': [108, 126, 304, 322, 2423, 2677, 3642], 'Administration': [109, 305], 'warfarin': [111, 307, 771, 858, 1482, 1492, 1497, 1504, 1525, 1579, 1616, 2538, 2549, 2586, 2609, 2679, 2761, 2785, 2820, 2842, 2938, 2966, 2974, 3151, 3578, 3622, 3632, 3693, 3711, 3821, 3863, 3897, 3923, 4047, 4179, 4291, 4563, 5058], 'inhibited': [112, 308, 767, 2669, 3339], 'GFR': [121, 317, 2117, 2124, 2411, 2918, 2930, 2949, 2960], 'Moreover,': [127, 323], 'found': [129, 144, 160, 325, 340, 356, 599, 2457, 2614, 2635, 2661, 3382, 3617, 4021, 4161, 4398], 'less': [130, 326], 'STZ-treated': [134, 330, 2470, 2981], 'knockout': [136, 332, 1076, 2983, 3011, 3027, 3041, 3074, 3120], 'mice': [137, 333, 1077, 1125, 1190, 1347, 1371, 1400, 1463, 3015, 3028, 3042, 3075, 3105, 3967, 4033, 4143], 'than': [138, 334, 1406, 2566, 2674, 3031, 3043, 3109, 3834], 'control': [139, 335, 1475, 1479, 2837, 2890, 3477], 'mice.': [140, 336, 1037, 2984, 3001, 3047, 3115, 4038], 'vitro': [142, 338, 2718, 3930, 4187, 4633], 'stimulation': [146, 342], 'cells': [149, 345, 838, 2166, 2180, 2219, 2248, 2287, 2299, 2310, 2339, 2482, 3193, 3368, 3387, 3412, 3424, 3449, 3504, 3922], 'with': [150, 346, 696, 1080, 1161, 1296, 1401, 1481, 1491, 1496, 1501, 1711, 1896, 1928, 2202, 2222, 2257, 2316, 2537, 2658, 2836, 3077, 3202, 3215, 3309, 3388, 3430, 3471, 3692, 3720, 3773, 3862, 3999, 4035, 4393, 4562, 4576, 4973], 'resulted': [152, 348], 'cell': [155, 351, 867, 1004, 1868, 1955, 1978, 2245, 2277, 2806, 3096, 3182, 3266, 3409, 3566, 3884, 4328, 4908, 4923, 4976, 5006, 5032, 5160, 5186, 5224], 'Thus': [157, 353, 3643], 'novel': [162, 358, 692, 3545, 3596, 3619, 5230], 'through': [167, 363, 3156, 3271, 4052, 4757], 'Gas6/Axl-mediated': [169, 365], 'pathway': [170, 181, 366, 377, 875, 1024, 2497, 2524, 3679, 3928, 5240], 'Inhibition': [177, 373], 'patients': [184, 380, 421, 659, 695, 3691, 3719, 3771, 3790, 4392], 'might': [185, 381, 2687, 3647, 4090, 4307, 5169], 'be': [186, 382, 601, 2398, 2526, 2688, 2753, 3594, 3648, 3655, 3699, 3713, 3793, 4049, 4556, 4582, 4614, 4971, 4992, 5074, 5170, 5192, 5242], 'beneficial': [187, 383, 5243], 'to': [188, 384, 473, 481, 547, 561, 600, 638, 689, 968, 976, 1174, 1196, 1258, 1582, 1877, 1885, 2103, 2382, 2397, 2425, 2499, 2690, 3324, 3581, 3654, 3694, 3730, 3784, 3792, 4526, 4542, 4585, 5073, 5150, 5244], 'slow': [189, 385], 'down': [190, 386], 'progression': [192, 388, 1028, 3584, 5247], 'transforming': [392], 'growth': [393, 563, 592, 702, 834, 1275, 3597, 4628, 5017, 5068], 'factor-β1': [394, 593], 'mitogen-activated': [399, 1904], 'protein': [400, 1905, 3289, 4579, 5122], 'Diabetes': [401], 'cause': [406, 3180], 'end': [408], 'stage': [409, 551, 3572], 'renal': [410, 505, 1766, 4093, 4313, 4436], 'disease': [411, 554, 2515, 4314, 5035], 'many': [413], 'countries.': [414], 'Approximately': [415], '30%': [416], 'type': [418, 631, 656, 3014, 3033, 3046, 3080, 3104, 3113, 4037, 4394], '1': [419, 1297, 1840, 1845, 1855, 3317, 3493, 4395], 'suffer': [422], 'from': [423, 726, 1041, 1054, 1068, 1128, 1184, 1187, 1516, 1585, 1674, 1680, 1754, 1765, 2086, 2631, 4144], 'nephropathy': [425, 480, 491, 608, 651, 959, 1017, 1031, 2437, 2508, 3147, 3154, 3552, 3575, 3697, 4066, 4338, 4491, 4969, 4999, 5190, 5220, 5249], '(1Bojestig': [426], 'M.': [427, 449, 661, 884, 920, 1092, 1206, 1534, 1622, 1723, 2018, 2043, 2720, 3932, 3969, 4115, 4117, 4192, 4228, 4255, 4651, 4687, 4714, 4763, 4794, 4832], 'Arnqvist': [428], 'H.J.': [429], 'Hermansson': [430], 'G.': [431, 574, 730, 734, 4340], 'Karlberg': [432], 'B.E.': [433], 'Ludvigsson': [434], 'J.': [435, 438, 529, 779, 788, 809, 817, 904, 939, 1111, 1425, 1554, 1642, 1740, 1785, 1802, 2031, 2144, 2737, 3660, 3746, 3759, 3806, 3949, 3988, 4075, 4113, 4119, 4212, 4245, 4270, 4373, 4415, 4671, 4704, 4729, 4782, 4811, 4847, 4948, 5135], 'N.': [436, 777, 2053, 3804], 'Engl.': [437, 3805], 'Med.': [439, 674, 3745, 3807, 4127], '1994;': [440], '330:': [441], '15-18Crossref': [442], 'PubMed': [443, 462, 538, 586, 621, 678, 743, 799, 821, 914, 945, 1117, 1223, 1248, 1431, 1450, 1564, 1652, 1808, 2037, 2062, 3666, 3751, 3765, 3811, 3851, 3994, 4015, 4084, 4131, 4222, 4281, 4353, 4379, 4424, 4514, 4607, 4681, 4740, 4788, 4858, 4961, 5105, 5139], 'Scopus': [444, 463, 539, 587, 622, 744, 800, 822, 915, 946, 1118, 1224, 1249, 1432, 1451, 1565, 1653, 1809, 2038, 2063, 3667, 3752, 3766, 3812, 3852, 3995, 4016, 4085, 4132, 4223, 4282, 4354, 4380, 4425, 4515, 4608, 4682, 4741, 4789, 4859, 4962, 5106, 5140], '(422)': [445], 'Google': [446, 465, 541, 589, 624, 679, 746, 802, 824, 917, 948, 1120, 1226, 1251, 1434, 1453, 1567, 1655, 1747, 1792, 1811, 2040, 2065, 2149, 2744, 3669, 3754, 3768, 3814, 3854, 3956, 3997, 4018, 4087, 4134, 4225, 4252, 4284, 4356, 4382, 4427, 4517, 4610, 4684, 4711, 4743, 4791, 4818, 4861, 4964, 5108, 5142], 'Scholar,': [447, 803, 918, 1227, 1435, 1793, 2041, 3755, 4226, 4253, 4685, 4712, 4792], '2Krolewski': [448], 'Eggers': [450], 'P.W.': [451], 'Warram': [452], 'J.H.': [453], 'Kidney': [454, 530, 575, 1240, 1678, 4343, 4416, 4953], 'Int.': [455, 576, 1241, 4344, 4954], '1996;': [456], '50:': [457], '2041-2046Abstract': [458], 'Full': [459, 535, 581, 583, 794, 796, 909, 911, 1245, 1559, 1561, 1647, 1649, 4081, 4217, 4219, 4276, 4278, 4348, 4350, 4421, 4676, 4678, 4735, 4737, 4853, 4855, 4958], 'Text': [460, 536, 582, 584, 795, 797, 910, 912, 1246, 1560, 1562, 1648, 1650, 4082, 4218, 4220, 4277, 4279, 4349, 4351, 4422, 4677, 4679, 4736, 4738, 4854, 4856, 4959], 'PDF': [461, 537, 585, 798, 913, 1247, 1563, 1651, 4083, 4221, 4280, 4352, 4423, 4680, 4739, 4857, 4960], '(142)': [464], 'Scholar).': [466, 542, 590, 625, 680, 825, 949, 1121, 1252, 1454, 1568, 1656, 1812, 2066, 2150, 3670, 3815, 3855, 3957, 4285, 4357, 4518, 4744, 4862, 5143], 'Therefore,': [467, 681, 2424, 2517, 2926, 3002, 3688, 4039, 4305, 4882], 'tremendous': [468], 'efforts': [469, 557], 'been': [471, 559, 3725, 4062], 'made': [472, 560, 1325, 1351], 'elucidate': [474, 562], 'molecular': [476, 5182], 'develop': [482], 'effective': [484, 637, 2527, 3580], 'treatment.': [485, 1493, 2587, 3506, 3705], 'feature': [487, 1009], 'characteristic': [488, 3568], 'persistent': [493], 'expansion': [497, 570, 4404], 'followed': [498, 1925, 2378, 4325], 'by': [499, 517, 652, 751, 768, 855, 869, 1327, 1353, 1507, 1707, 1926, 1965, 2082, 2120, 2159, 2271, 2275, 2313, 2343, 2373, 2379, 2585, 2643, 2965, 3164, 3344, 3369, 3398, 3427, 3453, 3554, 3778, 4315, 4326, 4447, 4558, 5221], 'glomerulosclerosis': [500, 510, 4554, 4588], 'decline': [503], 'function.': [506, 4094], 'mellitus': [513], 'always': [515, 4445], 'preceded': [516, 4446], 'hypertrophic': [520, 4450, 5078], 'processes': [521, 4451], 'compartment': [525], '(3Ziyadeh': [526, 4412], 'F.N.': [527, 2134, 4342, 4413], 'Am.': [528, 903, 1553, 1641, 1741, 1786, 2143, 2738, 3950, 4211, 4246, 4414, 4670, 4705, 4812], 'Dis.': [531, 4417], '1993;': [532, 740, 4418], '22:': [533, 4419], '736-744Abstract': [534, 4420], '(231)': [540, 4426], 'Because': [543, 1569, 2484, 2706, 2790, 2853, 4519], 'it': [544, 2686], 'regulate': [548], 'process,': [555], 'extensive': [556], 'factors': [564, 703], 'cytokines': [566], 'involved': [567, 3137, 3168, 5210], 'or': [571, 1395, 1915, 2212, 2594, 2703, 3392, 3875, 4568, 5019], '(4Wolf': [573], 'Suppl.': [577], '2000;': [578, 618, 3748, 3762, 3808], '77:': [579], 'S59-S66Abstract': [580], '(130)': [588], 'Transforming': [591], '(TGF-β1)1': [594], 'angiotensin': [596, 633], 'II': [597], 'are': [598, 636, 685, 2360, 3465, 3509, 3518, 3776, 5209], 'implicated': [602], 'among': [609, 2368], 'them': [610], '(5Lehmann': [611], 'R.': [612, 671, 1441, 1776, 4006, 4590, 5090], 'Schleicher': [613], 'E.D.': [614], 'Clin.': [615, 940, 1112, 1426, 1803, 2032, 3661, 3846, 3989, 4374, 4783], 'Chim.': [616], 'Acta.': [617], '297:': [619], '135-144Crossref': [620], '(144)': [623, 823], 'Although': [626, 2678, 3064, 3889, 4903, 4933, 5144], 'angiotensin-converting': [627, 641], 'enzyme': [628, 642], 'inhibitors': [629, 643], 'and/or': [630], 'I': [632], 'receptor': [634, 844], 'blockers': [635], 'some': [639, 4974, 5015], 'extent,': [640], 'can': [644, 974, 997, 1025, 2525, 2712, 2752, 2763, 2940, 3179, 3563, 3593, 3680, 4041, 4180, 4753, 4873, 4991], 'decrease': [645], 'risk': [647, 3797], 'developing': [649], 'only': [653, 4889], '12.5%': [654], '2': [657, 1389, 1586, 1842], '(6Ravid': [660], 'Brosh': [662], 'D.': [663, 669, 1414, 4121], 'Levi': [664], 'Z.': [665, 4502], 'Bar-Dayan': [666], 'Y.': [667, 922, 1094, 1208, 2008, 3971, 4498, 4765], 'Ravid': [668], 'Rachmani': [670], 'Ann.': [672], 'Intern.': [673], '1998;': [675, 1789, 2146], '128:': [676], '982-988Crossref': [677], 'additional': [682, 5024], 'pathogenetic': [683], 'mechanisms': [684], 'being': [686], 'urgently': [687], 'investigated': [688, 709, 4384], 'help': [690], 'design': [691], 'therapies': [693], 'for': [694, 704, 836, 1854, 1999, 2194, 2228, 2323, 2697, 3316, 3356, 3437, 3704, 3795, 4564, 4630, 5076, 5175, 5268, 5283], 'Among': [699], 'other': [700, 4477, 5016], 'potential': [701], 'cells,': [706, 1256, 3328], 'kidney': [722, 2578, 2814, 3066, 4912], 'disease.': [723], 'Gas6,': [724, 1899, 3227, 3345], 'cloned': [725], 'serum-starved': [727, 2182, 3326], 'fibroblasts': [728], '(7Manfioletti': [729], 'Brancolini': [731], 'C.': [732, 736, 1782, 4105, 5084], 'Avanzi': [733], 'Schneider': [735], 'Mol.': [737, 4509], 'Cell.': [738], 'Biol.': [739, 789, 4271, 4730, 4848, 5101], '13:': [741], '4976-4985Crossref': [742], '(532)': [745], 'Scholar),': [747, 2745, 3769, 4088, 5109], 'posttranslationally': [749], 'activated': [750], 'γ-carboxylation': [752], 'glutamate': [754], 'residues': [755], 'at': [756, 1142, 1301, 1305, 1605, 1857, 2079, 2169, 2290, 2320, 2478, 3219, 3434, 3824, 4157, 4302, 4473], 'N': [758], 'terminus': [759], 'presence': [762], 'vitamin': [764], 'K': [765], 'anticoagulant': [770, 3729, 3787, 3841], '(8Nakano': [772], 'T.': [773, 805, 890, 900, 902, 928, 930, 936, 938, 1100, 1102, 1108, 1110, 1202, 1540, 1550, 1552, 1628, 1638, 1640, 1731, 1737, 1739, 2012, 2020, 2051, 2055, 2728, 2734, 2736, 3940, 3946, 3948, 3977, 3979, 3985, 3987, 4198, 4208, 4210, 4236, 4242, 4244, 4259, 4267, 4269, 4657, 4667, 4669, 4695, 4701, 4703, 4718, 4726, 4728, 4771, 4773, 4779, 4781, 4802, 4808, 4810, 4836, 4844, 4846], 'Higashino': [774, 812], 'K.': [775, 781, 807, 811, 813, 888, 892, 894, 926, 1098, 1229, 1422, 1538, 1542, 1544, 1626, 1630, 1632, 1725, 1733, 1735, 1778, 2045, 2047, 2049, 2722, 2730, 2732, 3934, 3942, 3944, 3975, 4068, 4070, 4196, 4200, 4202, 4230, 4238, 4240, 4261, 4263, 4500, 4655, 4659, 4661, 4689, 4697, 4699, 4720, 4722, 4769, 4796, 4804, 4806, 4838, 4840, 4946, 4952], 'Kikuchi': [776], 'Kishino': [778, 808], 'Nomura': [780, 810], 'Fujita': [782], 'H.': [783, 787, 815, 886, 924, 1096, 1204, 1420, 1536, 1624, 1727, 1729, 2014, 2028, 2030, 2724, 2726, 3936, 3938, 3973, 4194, 4232, 4234, 4257, 4496, 4653, 4691, 4693, 4716, 4767, 4798, 4800, 4834], 'Ohara': [784], 'O.': [785, 4072], 'Arita': [786, 814], 'Chem.': [790, 4272, 4731, 4849], '1995;': [791, 4955], '270:': [792], '5702-5705Abstract': [793], '(165)': [801], '9Nakano': [804], 'Kawamoto': [806], 'Biochem.': [816], '1997;': [818, 1428, 1805], '323:': [819], '387-392Crossref': [820], 'Recently': [826], 'showed': [828, 2280, 2403, 2988, 4430], 'autocrine': [833], 'factor': [835, 3598, 4629, 4823, 5018, 5069], 'critical': [848], 'glomerulonephritis': [854, 882, 4647, 4996], 'showing': [856], 'extracellular': [861, 2857, 3279, 3292, 4323, 4468, 4484], 'domain': [862, 3280, 3293], 'inhibit': [865, 4181], 'proliferation': [868, 4756, 4897, 5007], 'specific': [870, 1139, 3355], 'blockade': [871], 'Gas6-mediated': [874, 3158, 3247], 'proliferative': [879], 'model': [880], '(10Yanagita': [883, 1533, 1621, 4191, 4650], 'Arai': [885, 923, 1095, 1535, 1623, 1728, 2725, 3937, 3972, 4193, 4233, 4256, 4652, 4692, 4715, 4766, 4799, 4833], 'Ishii': [887, 1419, 1537, 1625, 1724, 2721, 3933, 4195, 4229, 4654, 4688, 4795], 'Nakano': [889, 929, 1101, 1539, 1627, 1730, 2727, 3939, 3978, 4197, 4235, 4258, 4656, 4694, 4717, 4772, 4801, 4835], 'Ohashi': [891, 1541, 1629, 1732, 2015, 2729, 3941, 4199, 4237, 4260, 4658, 4696, 4719, 4803, 4837], 'Mizuno': [893, 1543, 1631, 1734, 2731, 3943, 4201, 4239, 4262, 4660, 4698, 4721, 4805, 4839], 'Varnum': [895, 1545, 1633, 4203, 4662], 'B.': [896, 1546, 1634, 4123, 4204, 4663], 'Fukatsu': [897, 933, 1105, 1547, 1635, 3982, 4205, 4264, 4664, 4723, 4776, 4841], 'A.': [898, 934, 1106, 1219, 1437, 1548, 1636, 1780, 2138, 3983, 4002, 4100, 4206, 4265, 4603, 4665, 4724, 4777, 4842], 'Doi': [899, 935, 1107, 1549, 1637, 1738, 2011, 2054, 2735, 3947, 3984, 4207, 4243, 4266, 4666, 4702, 4725, 4778, 4809, 4843], 'Kita': [901, 937, 1109, 1551, 1639, 1736, 2733, 3945, 3986, 4209, 4241, 4268, 4668, 4700, 4727, 4780, 4807, 4845], 'Pathol.': [905, 1555, 1643, 4213, 4507, 4510, 4672], '2001;': [906, 1556, 1644, 2034, 3663, 4128, 4214, 4273, 4673, 4732, 4850, 5102], '158:': [907, 1557, 1645, 4215, 4674], '1423-1432Abstract': [908, 1558, 1646, 4216, 4675], '(93)': [916, 1566, 1654, 4224, 4683], '11Yanagita': [919], 'Ishimoto': [921, 1093, 3970, 4764], 'Nagai': [925, 1097, 3974, 4768], 'Ito': [927, 1099, 3976, 4770], 'Salant': [931, 1103, 3980, 4774], 'D.J.': [932, 1104, 3981, 4775, 5098], 'Invest.': [941, 1113, 1427, 1804, 2033, 3662, 3990, 4375, 4784], '2002;': [942, 1114, 2059, 3991, 4785, 5136], '110:': [943, 1115, 3992, 4786], '239-246Crossref': [944, 1116, 3993, 4787], '(80)': [947, 1119, 3996, 4790], 'However,': [950, 2879, 3048, 3116, 3706, 3816, 4170, 4863], 'not': [961, 2583, 2598, 2620, 2682, 2909, 3062, 3238, 3401, 3868, 3880, 4168, 4462, 4918, 4931, 5004], 'determined.': [962, 2241], 'present': [964], 'study': [965, 2618, 3059, 3589, 4524, 4866], 'designed': [967], 'examine': [969, 2426], 'whether': [970, 993, 1019, 2521, 2748, 2760, 2929, 2937, 3177, 3264], 'contribute': [975], 'hypertrophyin': [982], 'vivo': [983, 4190, 4649, 4878], 'vitro.': [986, 3185, 4881], 'this': [988, 1175, 2523, 2530, 3539, 3774, 4044, 4147, 4523, 4865, 4899, 5200, 5239], 'study,': [989, 3540, 4148], 'specifically': [991, 3155, 3270, 3924, 4051], 'asked': [992], 'which': [1006, 2562, 3165, 3228, 3284, 3830, 4089], 'seen': [1010], 'inhibition': [1020, 4054], 'affect': [1026, 2683, 2764, 2941, 3239, 4293, 4308], '(STZ)': [1034], 'rats': [1035, 1062, 1320, 1398, 1461, 1469, 1476, 1480, 1485, 1490, 1495, 1571, 1597, 1769, 2087, 2098, 2536, 2552, 2603, 2633, 2657, 2673, 2935, 3860, 4472, 4494, 4561, 4575, 4929], 'obtained': [1040, 1127], 'Wako': [1042], 'Pure': [1043], 'Chemical': [1044, 2003], 'Inc.': [1045, 1057, 1131], 'Ltd.': [1046], '(Osaka,': [1047, 1132], 'Japan).': [1048, 1074, 1133, 1666], 'Recombinant': [1049, 3207], 'human': [1050, 1750, 3297], 'TGF-β1': [1051, 3259, 3393], 'purchased': [1053, 1067], 'R&D': [1055], 'Systems,': [1056], '(Minneapolis,': [1058], 'MN).': [1059], 'Male': [1060, 1319], 'Sprague-Dawley': [1061], 'weighing': [1063, 1321], '170–200': [1064, 1322], 'g': [1065, 1323], 'Shimizu': [1069], 'Laboratory': [1070], 'Animal': [1071, 1144], 'center': [1072], '(Hamamatsu,': [1073], 'generated': [1079], 'targeted': [1082], 'disruption': [1083], 'as': [1088, 1380, 1411, 1619, 1866, 2281, 2302, 2362, 2542, 2571, 2611, 2648, 3194, 3256, 3300, 3376, 3415, 3511, 3623, 3727, 3839, 4442, 5172], 'previously': [1089, 1199], 'described': [1090, 1200, 1620, 3416], '(11Yanagita': [1091, 3968, 4762], 'Control': [1122], 'inbred': [1123], 'C57BL/6': [1124], 'Clea': [1129], 'Japan,': [1130], 'animals': [1135], 'housed': [1137, 2088], 'under': [1138, 3372, 4176], 'pathogen-free': [1140], 'conditions': [1141], 'Facilities': [1145], 'Kyoto': [1147, 1169], 'University,': [1148], 'Faculty': [1149], 'Medicine.': [1151], 'All': [1152], 'animal': [1155, 1682, 4571], 'experiments': [1156, 3470, 3866], 'performed': [1158, 2372], 'accordance': [1160], 'institutional': [1162], 'guidelines,': [1163], 'Review': [1166], 'Board': [1167], 'University': [1170, 5264], 'granted': [1171], 'ethical': [1172], 'permission': [1173], 'study.': [1176], 'primary': [1180, 1714], 'culture': [1181], 'established': [1183], 'glomeruli': [1185, 1817, 1821, 2071, 2630, 4059, 5049], 'isolated': [1186, 1764, 2629], 'normal': [1188], '4-week-old': [1189], '(C57BL/6JxSJL/J)': [1191], 'identified': [1194], 'according': [1195], 'method': [1198, 1774], '(12Doi': [1201], 'Vlassara': [1203], 'Kirstein': [1205], 'Yamada': [1207], 'Striker': [1209, 1211, 1230, 1238], 'G.E.': [1210, 1239], 'L.J.': [1212, 1231], 'Proc.': [1213, 4597], 'Natl.': [1214, 4598], 'Acad.': [1215, 4599], 'Sci.': [1216, 4600], 'U.': [1217, 4601], 'S.': [1218, 1233, 2016, 2022, 2024, 2026, 3801, 4074, 4602, 5129], '1992;': [1220, 4511], '89:': [1221], '2873-2877Crossref': [1222], '(325)': [1225], '13MacKay': [1228], 'Elliot': [1232], 'Pinkert': [1234], 'C.A.': [1235], 'Brinster': [1236], 'R.L.': [1237], '1988;': [1242], '33:': [1243], '677-684Abstract': [1244], '(152)': [1250], 'Phenotypically': [1253], 'stable': [1254], '12th': [1257], '16th': [1259], 'passages,': [1260], 'plated': [1262, 2168, 2289], 'on': [1263, 1529, 2347, 2821, 2975, 3352, 3457, 3898], '100-mm': [1264, 2296], 'plastic': [1265], 'dishes': [1266], '(Nalge': [1267], 'Nunc': [1268], 'International,': [1269], 'Roskilde,': [1270], 'Denmark)': [1271], 'maintained': [1273], 'medium': [1276, 1285, 2187, 2198, 2206, 3315], '(3:1': [1277], 'mixture': [1278], "Dulbecco's": [1280, 2184], 'modified': [1281, 1286, 2185], "Eagle's": [1282, 2186], "medium/Ham's": [1283], 'F-12': [1284], 'trace': [1287], 'elements)': [1288], '(Nissui': [1289], 'Pharmaceutical': [1290], 'Co.,': [1291, 2004], 'Ltd.,': [1292, 1510, 1697, 2264], 'Tokyo,': [1293, 1511, 1665, 1698, 2005], 'Japan)': [1294, 1512, 2006], 'supplemented': [1295], 'mm': [1298, 1828, 1833, 1843], 'glutamine,': [1299], 'penicillin': [1300], '100': [1302, 1306, 3390, 3482, 3487], 'units/ml,': [1303], 'streptomycin': [1304], 'μg/ml': [1307, 1849], '(Invitrogen)': [1308], '20%': [1310], 'fetal': [1311], 'bovine': [1312, 2190], 'serum': [1313, 1610, 2191, 3825], '(Cansera': [1314], 'International': [1315], 'Inc.,': [1316, 2162], 'Rexdale,': [1317], 'Canada).': [1318], 'single': [1329], 'intravenous': [1330], 'injection': [1331, 1374, 1392, 1589, 2421, 2455, 2907, 2999, 5055], '(55': [1334], 'mg/kg': [1335], 'body': [1336, 2575], 'weight)': [1337], '0.05': [1339, 2556, 2560], 'mol/liter': [1340, 1366], 'citrate': [1341, 1367, 1376], 'buffer': [1342, 1377, 1826], '(pH': [1343], '4.5).': [1344], 'Weight-matched': [1345], '8-week-old': [1346], '(17–20': [1348], 'g)': [1349], 'two': [1354, 2388], 'consecutive': [1355], 'daily': [1356], 'intraperitoneal': [1357], 'injections': [1358], '(150': [1361], 'mg/kg)': [1362], 'dissolved': [1363], '0.01': [1365], 'buffer.': [1368], 'Rats': [1369], 'receiving': [1372], 'used': [1379, 1410, 1865, 2441, 2696, 2980, 3276, 3726, 4150, 5171], 'controls.': [1381], 'levels': [1383, 1404, 3052], 'blood': [1385, 1402, 3050], 'glucose': [1386, 1403, 3051], 'determined': [1388, 1527, 1992, 4905], 'days': [1390, 1587], 'vehicle,': [1396], 'more': [1405, 1574], '>16.7': [1407], 'mmol/liter': [1408], '(14Koya': [1413], 'Jirousek': [1415], 'M.R.': [1416], 'Lin': [1417], 'Y.W.': [1418], 'Kuboki': [1421], 'King': [1423], 'G.L.': [1424], '100:': [1429, 1806], '115-126Crossref': [1430], '(485)': [1433], '15Flyvbjerg': [1436], 'Bennett': [1438, 4003], 'W.F.': [1439, 4004], 'Rasch': [1440, 4005], 'Kopchick': [1442, 4007], 'J.J.': [1443, 4008], 'Scarlett': [1444, 4009], 'J.A.': [1445, 2140, 4010], 'Diabetes.': [1446, 4011], '1999;': [1447, 1744, 2741, 3953, 4012, 4249, 4345, 4708, 4815], '48:': [1448, 4013], '377-382Crossref': [1449, 4014], '(145)': [1452, 4017], 'Twelve': [1455, 1592], 'injection,': [1459, 1595, 2627, 2829, 2948], 'weighed': [1465, 1599], 'sacrificed.': [1467, 1601], 'divided': [1471], 'into': [1472, 2236], 'four': [1473], 'groups:': [1474], 'without': [1477, 1486, 3235, 4893], 'treatment,': [1478, 1483, 1487, 2308, 3421], 'treatment': [1498, 2610, 2680, 2762, 2786, 2939, 2967, 3384, 3633, 5059], 'administered': [1500], '0.25': [1502], 'mg/liter': [1503, 1584], 'potassium': [1505], '(provided': [1506], 'Eisai': [1508], 'Co.': [1509, 1696], 'drinking': [1514, 2540], 'water': [1515, 2541], 'day': [1518], 'dosage': [1523, 1577], 'based': [1528], 'previous': [1531, 2617], 'report': [1532], 'drink': [1572], 'much': [1573], 'water,': [1575], 'reduced': [1581], '0.06': [1583], 'STZ.': [1591], 'Blood': [1602], 'collected': [1604], 'sacrifice.': [1606], 'Prothrombin': [1607], 'times,': [1608, 2592], 'hematocrits,': [1609], 'creatinine,': [1611], 'plasma': [1613], 'concentrations': [1614, 2111, 2209, 2547, 2570, 3204, 3826, 3838, 4159], 'measured': [1618, 1659, 1673, 1958, 2078, 2158, 2804, 2871, 3187], 'HbA1c': [1657, 3036], 'using': [1660, 1770, 1941, 1993, 4569], 'DCA2000': [1661], 'analyzer': [1662, 1996], '(Bayer': [1663], 'Medical,': [1664], 'Before': [1667], 'sacrifice,': [1668], 'creatinine': [1669, 2110], 'albumin': [1671, 2152, 2192, 2952, 3638], '24-h': [1675, 2083], 'urine': [1676, 2084, 2095, 2109, 2156], 'collection.': [1677], 'tissues': [1679], 'each': [1681, 1873, 1974, 2068, 2369], 'snap': [1684], 'frozen': [1685], 'cold': [1687], 'acetone': [1688], 'optimal': [1690], 'cutting': [1691], 'temperature': [1692], 'compound': [1693], '(Sakura': [1694], 'Finetechnical': [1695], 'Japan),': [1699], 'cryostat': [1701], 'sections': [1702], '(4': [1703], 'μm)': [1704, 3843], 'stained': [1706], 'indirect': [1708], 'immunofluorescence': [1709], 'procedure': [1710], 'following': [1713, 2122], 'antibodies:': [1715], 'rabbit': [1716, 1897, 1902, 1916], 'polyclonal': [1717, 1908, 1919], 'antibodies': [1718], 'against': [1719], 'rat': [1720, 2444, 2813, 4901], '(16Yanagita': [1722, 2719, 3931], 'Ozaki': [1726, 2723, 3935, 4231, 4690, 4797], 'Soc.': [1742, 1787, 2739, 3951, 4247, 4706, 4813], 'Nephrol.': [1743, 1788, 2056, 2740, 3952, 4248, 4707, 4814], '10:': [1745, 2742, 3954, 4250, 4709, 4816], '2503-2509PubMed': [1746, 2743, 3955, 4251, 4710, 4817], 'Scholar)': [1748, 3998, 4019, 4135, 4383, 4428, 4611, 4819, 4965], '(generous': [1752], 'gift': [1753], 'Dr.': [1755], 'Brian': [1756], 'Varnum,': [1757], 'Amgen,': [1758], 'Thousand': [1759], 'Oaks,': [1760], 'CA).': [1761, 2357], 'Glomeruli': [1762], 'cortices': [1767], 'differential': [1772], 'sieving': [1773], '(17Ziswiler': [1775], 'Steinmann-Niggli': [1777], 'Kappeler': [1779], 'Daniel': [1781], 'Marti': [1783], 'H.P.': [1784], '9:': [1790], '2055-2066PubMed': [1791], '18Pippin': [1794], 'J.W.': [1795], 'Qu': [1796], 'Q.': [1797], 'Meijer': [1798], 'L.': [1799, 5092], 'Shankland': [1800], 'S.J.': [1801], '2512-2520Crossref': [1807], '(131)': [1810], 'purity': [1814], '>90%.': [1819], 'Isolated': [1820], 'suspended': [1823], 'RIPA': [1825], '(50': [1827], 'Tris,': [1829], 'pH': [1830], '7.5,': [1831], '150': [1832], 'NaCl,': [1834], '1%': [1835], 'Nonidet': [1836], 'P-40,': [1837], '0.25%': [1838], 'SDS,': [1839], 'mmNa3VO4,': [1841], 'EDTA,': [1844], 'mmphenylmethylsulfonyl': [1846], 'fluoride,': [1847], '10': [1848, 2324, 3310, 3438], 'aprotinine),': [1851], 'incubated': [1853, 1895], 'h': [1856], '4': [1858], '°C.': [1859], 'After': [1860, 1879, 2176, 2215, 2307, 2622, 2824, 2943, 3307, 3420], 'centrifugation,': [1861], 'supernatants': [1863], 'total': [1867], 'lysates.': [1869], '60': [1870], 'μg': [1871], 'sample': [1874], 'applied': [1876], 'SDS-PAGE.': [1878], 'electrophoresis,': [1880], 'proteins': [1882], 'transferred': [1884], 'nitrocellulose': [1886], 'filters': [1887], '(Schleicher': [1888], '&': [1889], 'Schuell).': [1890], 'blots': [1892], 'subsequently': [1894], 'anti-rat': [1898], 'anti-human': [1900], 'anti-phospho-p44/p42': [1903], '(MAP)': [1906], 'kinase': [1907, 1918, 2716, 2751, 2774, 5044, 5157, 5168], 'antibody': [1909, 1920, 1945, 2695], '(Cell': [1910], 'Signaling': [1911], 'Technology,': [1912], 'Beverly,': [1913], 'MA),': [1914], 'anti-MAP': [1917], '(Oncogene,': [1921], 'San': [1922, 2355], 'Diego,': [1923], 'CA),': [1924], 'incubation': [1927, 3201], 'horseradish': [1929, 1942], 'peroxidase-conjugated': [1930, 1943], 'goat': [1931], 'anti-rabbit': [1932], 'IgG': [1933], '(Amersham': [1934, 1951], 'Biosciences).': [1935, 1952], 'immunoreactive': [1937], 'bands': [1938], 'visualized': [1940], 'secondary': [1944], 'enhanced': [1948], 'chemiluminescent': [1949], 'system': [1950], 'area': [1956, 1985, 1990, 2875, 2888, 4909], 'hematoxylin': [1961], 'eosin': [1962], 'staining': [1963], 'section': [1964], 'Image-Pro': [1966], 'Plus': [1967], '(Media': [1968], 'Cybernetics,': [1969], 'Silver': [1970], 'Spring,': [1971], 'MD).': [1972], 'For': [1973, 2067, 2242], 'animal,': [1975, 2069], '50': [1976, 2070], 'areas': [1979, 2810, 2831, 2850, 3100, 3126, 4027], 'analyzed.': [1981, 2073], 'surface': [1984, 2809, 3099], 'periodic': [1988, 2873, 2886], 'acid-methenamine-silver-positive': [1989, 2874, 2887], 'image': [1995], '(Image': [1997], 'Processor': [1998], 'Analytical': [2000], 'Pathology;': [2001], 'Sumitomo': [2002], '(19Yamamoto': [2007], 'Kato': [2009], 'I.': [2010], 'Yonekura': [2013], 'Takeuchi': [2017], 'Watanabe': [2019, 2050], 'Yamagishi': [2021], 'Sakurai': [2023], 'Takasawa': [2025], 'Okamoto': [2027], 'Yamamoto': [2029], '108:': [2035], '261-268Crossref': [2036], '(448)': [2039], '20Hirata': [2042], 'Makibayashi': [2044], 'Katsumata': [2046], 'Kusano': [2048], 'Fukushima': [2052], 'Dial.': [2057], 'Transplant.': [2058], '17:': [2060], '2132-2137Crossref': [2061], '(68)': [2064], 'Urine': [2074], 'volume': [2075], '(Vu)': [2076], 'collection': [2085], 'individual': [2090], 'metabolic': [2091], 'cages.': [2092], 'During': [2093], 'collection,': [2096], 'allowed': [2100], 'free': [2101], 'access': [2102], 'food': [2104], 'water.': [2106], 'Serum': [2107], '(Cp': [2112], 'andCu)': [2113], 'measured,': [2115], 'calculated': [2119], 'equation:': [2123], '=': [2125], '(Cu/Cp)': [2126], '×Vu/body': [2127], 'weight': [2128, 2576, 2580, 3068], '(21Stockelman': [2129], 'M.G.': [2130], 'Lorenz': [2131], 'J.N.': [2132], 'Smith': [2133], 'Boivin': [2135], 'G.P.': [2136], 'Sahota': [2137], 'Tischfield': [2139], 'Stambrook': [2141], 'P.J.': [2142], 'Physiol.': [2145], '275:': [2147], 'F154-F163PubMed': [2148], 'concentration': [2153], 'Nephrat': [2160], '(Exocell': [2161], 'Philadelphia,': [2163], 'PA).': [2164], 'Mesangial': [2165, 2286], '1.5': [2170], '×': [2171, 2292], '104cells/well': [2172], '24-well': [2174], 'dishes.': [2175], '48': [2177, 2195], 'h,': [2178, 2217, 2230, 3318], 'containing': [2188], '0.5%': [2189], '(Sigma-Aldrich)': [2193], 'h.': [2196], 'then': [2200, 2240, 2327, 2341, 3333, 3441, 3451], 'replaced': [2201], 'fresh': [2204], 'starving': [2205, 3314], 'including': [2207], 'various': [2208, 3203], 'agonist': [2211], 'left': [2213], 'untreated.': [2214], '18': [2216], 'labeled': [2221], '[3H]leucine': [2223, 2235, 2304, 3188, 3212, 3240, 3250, 3330, 3342, 3377], '(2': [2224], 'μCi/ml;': [2225], 'Amersham': [2226], 'Biosciences)': [2227], '6': [2229, 3092], 'incorporation': [2233, 2273, 2305, 3189, 3210, 3213, 3241, 3251, 3331, 3343, 3378], 'acid-precipitable': [2237], 'materials': [2238], 'determination': [2243], 'number,': [2246], 'trypsinized,': [2250], 'resuspended': [2251, 2328], 'phosphate-buffered': [2253, 2317, 3431], 'saline,': [2254, 2318, 3432], 'counted': [2256], 'Coulter': [2259], 'counter': [2260], 'Z1': [2261], '(Coulter': [2262], 'Electronics': [2263], 'Hialeah,': [2265], 'FL).': [2266], 'data': [2268, 2359, 2402, 2987, 3131, 3464, 3508, 3628], 'normalized': [2270], 'dividing': [2272], 'counts': [2274], 'number': [2278, 4924], 'fold': [2282, 3512], 'increases': [2283, 3513], 'over': [2284, 3514], 'control.': [2285, 3515], '4.5': [2291], '105': [2293], 'cells/well': [2294], 'plates.': [2297], 'treated': [2301, 2535, 2655, 3414, 3794, 3861, 3965], 'procedure.': [2306], 'harvested': [2312, 3426], 'tripsinization,': [2314, 3428], 'washed': [2315, 3429], 'centrifuged': [2319, 3433], '1,500': [2321, 3435], 'rpm': [2322, 3436], 'min,': [2325, 3439], 'ice-cold': [2330, 3444], '70%': [2331, 3445], 'ethanol': [2332], 'added': [2333, 3323], 'dropwise': [2334], 'while': [2335], 'vortexing.': [2336], 'Ethanol-fixed': [2337, 3447], 'analyzed': [2342, 2447, 3004, 3452, 4540], 'forward': [2344, 3454, 3500, 3531], 'light': [2345, 3455], 'scattering': [2346, 3456], 'Becton': [2349, 3459], 'Dickinson': [2350, 3460], 'flow': [2351, 3370, 3461], 'cytometer': [2352], '(BD': [2353], 'Biosciences,': [2354], 'Jose,': [2356], 'expressed': [2361], 'means': [2364, 3498, 3520], '±': [2365, 2555, 2559, 3521], 'S.D.': [2366, 3522], 'Comparison': [2367], 'group': [2370, 2471], 'one-way': [2374], 'analysis': [2375, 3406], 'variance': [2377], 'Neuman-Keuls': [2380], 'test': [2381], 'evaluate': [2383], 'statistical': [2385], 'significance': [2386], 'between': [2387, 2889, 4402, 4550], 'groups.': [2389, 2878], 'A': [2390], 'p': [2391], 'value': [2392], '<0.05': [2394], 'considered': [2396], 'significant.': [2399], 'Our': [2400, 2985, 3588, 3627], 'preliminary': [2401, 2986], 'vivo,': [2439], 'STZ-induced': [2442], 'kidney.': [2445], 'glomerulus': [2449], 'both': [2461, 2830, 2877, 3125, 4023, 4995], 'significantly': [2466, 2564, 2833, 2955, 3107, 3128, 3832, 3869, 3887, 4029], 'they': [2474], 'mostly': [2476], 'localized': [2477], 'endothelial': [2479], '(Fig.1).': [2483], 'induced': [2491, 4993], 'seems': [2498, 5072], 'process.': [2516, 5036], 'next': [2519], 'examined': [2520, 2747, 2816, 2928, 3176], 'inhibiting': [2522], 'treating': [2529, 3689, 4559], 'experimental': [2531], 'shown': [2543, 2649, 2709, 2768, 3023, 3089, 3510, 3543, 3892, 3918, 4623, 4750, 4870, 5040], 'Fig.2.': [2545], 'Plasma': [2546], 'these': [2551, 4158, 4177], '0.71': [2554], '0.67': [2558], 'μm,': [2561, 3829], 'lower': [2565, 3833], 'ordinary': [2568, 3836], 'therapeutic': [2569, 3837], 'anticoagulant.': [2573], 'weight/body': [2579, 3067], 'values': [2581, 3517], 'changed': [2584], 'Significant': [2588], 'prolongation': [2589, 3780, 4163], 'prothrombin': [2591, 3782, 3857, 4165], 'anemia,': [2593], 'bleeding': [2595, 3799, 3873], 'tendency': [2596, 3874], 'all': [2601], 'during': [2604], 'whole': [2606], 'period': [2607, 3060], 'already': [2613, 3917, 4172, 4622], 'our': [2616, 3865, 4457, 4520], '(data': [2619, 2908, 3061, 3879, 4167, 4930], 'shown).': [2621, 2910, 3063, 4169, 4932], 'Western': [2644, 2698], 'blotting': [2645, 2699], '(Fig.': [2646, 2851, 3379], '3)': [2647], 'Fig.': [2651, 2770, 3091, 3418], '1.': [2652], 'When': [2653], 'warfarin,': [2659, 4155], 'markedly': [2668], 'warfarin-treated': [2671], 'untreated': [2675, 3114], 'did': [2681, 3237, 4917], 'expression,': [2685], 'due': [2689], 'fact': [2692], 'cannot': [2700], 'discriminate': [2701], 'active': [2702], 'inactive': [2704, 3231], 'Gas6.': [2705, 3206, 3555, 4056], 'activate': [2713], 'p44/42': [2714, 2749, 2772], 'MAP': [2715, 2750, 2773, 5043, 5117, 5156, 5167], 'phosphorylated': [2754, 2776, 5046], 'lysates': [2758, 2780], 'phosphorylation.': [2766, 2789, 5062], 'As': [2767, 3022, 3088], '3,': [2771], 'abolished': [2787, 5060], 'their': [2788], 'earliest': [2797], 'structural': [2798, 2864], 'alterations': [2799], 'nephropathy,': [2802, 2868, 2917, 3903, 4538], 'effect': [2818, 3349, 3709, 3819, 3895, 3912, 4045, 5079], 'enlarged': [2834], 'compared': [2835, 3076, 4034], 'administration': [2840], 'prevented': [2843], '4).': [2852], 'accumulation': [2854, 4466], 'matrix': [2858, 4324, 4469, 4485], 'components': [2859], 'also': [2861, 2870, 3132, 3629, 4061, 4429, 5272], 'change': [2865, 2883, 2901], 'there': [2880, 2896, 3082], 'no': [2882, 2898, 3084, 3872, 4162, 5147], 'groups,': [2893], 'indicating': [2894], 'sclerotic': [2900], 'patients.': [2925, 5252], 'GFR.': [2942], 'urinary': [2951, 3637], 'excretion': [2953, 3639], 'increased,': [2956], 'suppressed': [2964], '(Fig.5).': [2968], 'To': [2969, 3160, 3262, 3958], 'confirm': [2970, 3960], 'specificity': [2972, 3909], 'pathway,': [2978, 3274], 'wild': [3013, 3032, 3045, 3079, 3103, 3112, 4036], 'Fig.6A,': [3025], 'smaller': [3030, 3070], 'mice,': [3034, 3081, 3121], 'higher': [3038], 'almost': [3054, 3253], 'same': [3056, 3223, 3255, 3374], 'throughout': [3057], 'statistically': [3085], 'significant': [3086], 'difference.': [3087], '(B': [3093], 'andC),': [3094], 'larger': [3108], 'suppressed.': [3129], 'These': [3130, 3789], 'indicate': [3133, 5151], 'initial': [3143, 3609, 4534, 5216], 'suggest': [3149], 'inhibits': [3152, 3925], 'pathway.': [3159, 3306], 'investigate': [3161], 'mouse': [3191, 3243], 'marker': [3196, 5174], 'cellular': [3198, 3364, 3396], 'dose-dependently,': [3214], '1.5-fold': [3217], 'maximum': [3220], '(Fig.7).': [3221], 'dose': [3224, 4153], 'Gla-defective': [3226, 3402, 3490], 'form': [3232], 'γ-carboxylation,': [3236], 'cells.': [3245], '(1': [3260], 'ng/ml).': [3261], 'clarify': [3263], 'mediated': [3269, 3553, 4050], 'Gas6-Axl': [3273, 3305, 3358], 'recombinant': [3278, 3287], '(Axl-Fc),': [3283], 'fusion': [3288], 'Fc': [3298], 'portion,': [3299], 'inhibitor': [3302], 'preincubation': [3308], 'nm': [3311], 'Axl-Fc': [3312, 3338], '(100': [3320], 'ng/ml)': [3321], 'measured.': [3334], 'addition': [3336], 'suggesting': [3346], 'interaction.': [3359], 'Further,': [3360], 'checked': [3362], 'size': [3365, 3397], 'cytometry': [3371], 'protocol': [3375], '8).': [3380], 'ng/ml': [3391, 3483, 3488, 3494], '1.1-fold': [3399], 'but': [3400], 'Gas6.Figure': [3403], '8Flow': [3404], 'cytometric': [3405], 'size.': [3410], '7.': [3419], 'resuspend': [3442], 'ethanol.': [3446], 'cytometer.': [3462], 'representative': [3466], 'six': [3468, 3524], 'independent': [3469, 3525], 'qualitatively': [3472], 'similar': [3473], 'changes.': [3474], 'Thin': [3475], 'line,': [3476, 3480], '(Cont);': [3478], 'bold': [3479], 'agonist.A,': [3481], 'Gas6;': [3485, 3491], 'B,': [3486], 'C,': [3492], 'TGF-β1.': [3496], 'D,': [3497], 'scatter': [3501], 'experiments.': [3526, 4619], '**,p': [3527], '<': [3528], '0.05.': [3529], 'FSC,': [3530], 'scatter.View': [3532], 'Large': [3533], 'Image': [3534], 'Figure': [3535], 'ViewerDownload': [3536], '(PPT)': [3537], 'This': [3556, 5226], 'first': [3559, 5203], 'demonstration': [3560, 5204], 'induce': [3564, 4754, 4874, 5005], 'prevent': [3582, 3695, 3731, 4298, 5245], 'implies': [3590], 'plays': [3600, 4637], 'crucial': [3602], 'aspect': [3620], 'anti-hypertrophic': [3625, 3818], 'agent.': [3626], 'ameliorated': [3634], 'hyperfiltration': [3635, 3646], 'interactive': [3650], 'presumed': [3653], 'causally': [3656], 'linked': [3657], '(22Hostetter': [3658], 'T.H.': [3659], '107:': [3664], '161-162Crossref': [3665], '(46)': [3668], 'It': [3671, 4286, 4986, 5011], 'conceivable,': [3673], 'therefore,': [3674], 'blocking': [3676], 'improve': [3681], 'vicious': [3683], 'cycle': [3684], 'would': [3698, 4048, 4581, 5241], 'options': [3703], 'side': [3708], 'should': [3712, 4555, 4613, 5191], 'noted': [3714], 'if': [3715], 'treat': [3717], 'warfarin.': [3721, 3914], 'Warfarin': [3722], 'has': [3723, 4060], 'long': [3724], 'thrombosis': [3732], 'embolism': [3734], '(23Gallus': [3735], 'A.S.': [3736], 'Baker': [3737], 'R.I.': [3738], 'Chong': [3739], 'B.H.': [3740], 'Ockelford': [3741], 'P.A.': [3742], 'Street': [3743], 'A.M.': [3744], 'Aust.': [3747], '172:': [3749], '600-605Crossref': [3750], '(102)': [3753], '24Booth': [3756], 'S.L.': [3757], 'Mayer': [3758], 'Nutr.': [3760], 'Rev.': [3761], '58:': [3763], '20-22Crossref': [3764], '(23)': [3767], 'prescribed': [3772], 'agent': [3775], 'monitored': [3777], 'measuring': [3779], 'times': [3783, 3858], 'achieve': [3785], 'effect.': [3788], '(25Schulman': [3800], 'Lindmarker': [3802], 'P.': [3803, 4103, 4109, 4125], '342:': [3809], '1953-1958Crossref': [3810], '(319)': [3813], 'achieved': [3823], '0.7': [3828], '(4–5': [3842], '(26Holford': [3844], 'N.H.': [3845], 'Pharmacokinet.': [3847], '1986;': [3848], '11:': [3849], '483-504Crossref': [3850], '(219)': [3853], 'prolonged,': [3870], 'anemia': [3876], 'shown),': [3881], 'whereas': [3882], 'inhibited.': [3888], 'clear': [3894], 'question': [3905, 4885], 'about': [3907], 'further': [3959, 5193], 'specificity,': [3962], 'Gas6-deficient': [3966, 4032], '(15Flyvbjerg': [4001], 'decreased': [4030], 'conclude': [4042], 'Hypercoagulability': [4057], '(27Kaizu': [4067], 'Uriu': [4069], 'Hashimoto': [4071], 'Eto': [4073], 'Diabet.': [4076], 'Complications.': [4077], '1991;': [4078], '5:': [4079], '92-94Abstract': [4080], '(3)': [4086], 'worsen': [4091], 'Recently,': [4095], 'Angelillo-Scherrer': [4096], 'et': [4097, 4359, 4935], 'al.': [4098, 4360, 4936], '(28Angelillo-Scherrer': [4099], 'de': [4101], 'Frutos': [4102], 'Aparicio': [4104], 'Melis': [4106], 'E.': [4107, 4944], 'Savi': [4108], 'Lupu': [4110], 'F.': [4111], 'Arnout': [4112], 'Dewerchin': [4114], 'Hoylaerts': [4116], 'Herbert': [4118], 'Collen': [4120], 'Dahlback': [4122], 'Carmeliet': [4124], 'Nat.': [4126, 5099], '7:': [4129], '215-221Crossref': [4130], '(365)': [4133], 'deficiency': [4139], 'protects': [4142], 'thrombosis.': [4145], 'low': [4152, 4303], 'time': [4166, 4567], 'even': [4175, 4301], 'concentrations,': [4178], 'activation': [4183, 5114], '16Yanagita': [4227, 4686, 4793], '29Yanagita': [4254, 4713], '276:': [4274, 4733, 4851], '42364-42369Abstract': [4275, 4734, 4852], '(82)': [4283, 4742, 4860], 'still': [4288], 'possible': [4289], 'could': [4292, 4461], 'coagulation': [4295, 4318], 'cascades': [4296], 'thrombotic': [4299], 'events': [4300], 'concentrations.': [4304], 'improving': [4316], 'state.': [4319], 'major': [4334, 4981], 'characteristics': [4335], '(30Wolf': [4339], 'Ziyadeh': [4341, 4411], '56:': [4346], '393-405Abstract': [4347], '(431)': [4355], 'Mauer': [4358], '(31Mauer': [4361], 'S.M.': [4362], 'Steffes': [4363], 'M.W.': [4364], 'Ellis': [4365], 'E.N.': [4366], 'Sutherland': [4367], 'D.E.': [4368], 'Brown': [4369], 'D.M.': [4370], 'Goetz': [4371], 'F.C.': [4372], '1984;': [4376], '74:': [4377], '1143-1155Crossref': [4378], '(1064)': [4381], 'structural-functional': [4386], 'relationship': [4387], 'cross-section': [4390], 'diabetes.': [4396], 'They': [4397], 'close': [4400], 'correlation': [4401, 4549], 'clinical': [4406], 'manifestations': [4407], 'irreversible': [4435], 'changes': [4437], 'mellitus,': [4440], 'such': [4441], 'glomerulosclerosis,': [4443], 'compartment.': [4455], 'experiment,': [4458], 'find': [4463], 'excessive': [4465], 'weeks,': [4475], 'although': [4476], 'investigators': [4478], 'deposition': [4482], 'later': [4488], '(32Makino': [4495], 'Yamasaki': [4497], 'Hironaka': [4499], 'Ota': [4501], 'Virchows': [4503], 'Arch.': [4504], 'B': [4505], 'Cell': [4506, 5100], 'Incl.': [4508], '62:': [4512], '19-24Crossref': [4513], '(18)': [4516], 'purpose': [4521], 'determine': [4527], 'up': [4541], 'evaluated': [4557], 'longer': [4566], 'another': [4570, 4583], 'model.': [4572, 4902], 'Treating': [4573], 'high': [4578], 'diet': [4580], 'way': [4584], 'accelerate': [4586], '(33Zatz': [4589], 'Meyer': [4591], 'T.W.': [4592], 'Rennke': [4593], 'H.G.': [4594], 'Brenner': [4595], 'B.M.': [4596], '1985;': [4604], '82:': [4605], '5963-5967Crossref': [4606], '(483)': [4609], 'tested': [4615], 'future': [4618, 5196], 'cellsin': [4632], 'acute': [4642], 'chronic': [4644], 'forms': [4645], 'studies,': [4747], 'tyrosine': [4759], 'kinase,': [4760, 5118, 5123], 'transcription': [4822, 4829], 'signal': [4824], 'transducer': [4825], 'activator': [4827], '3': [4830], '(29Yanagita': [4831], 'clearly': [4869, 5039], 'obvious': [4884], 'why': [4887, 4989, 5001], 'induces': [4890], 'affecting': [4894], 'notice': [4919], 'Young': [4934], '(34Young': [4937], 'B.A.': [4938, 5088], 'Johnson': [4939], 'R.J.': [4940], 'Alpers': [4941], 'C.E.': [4942], 'Eng': [4943], 'Gordon': [4945], 'Floege': [4947], 'Couser': [4949], 'W.G.': [4950], 'Seidel': [4951], '47:': [4956], '935-944Abstract': [4957], '(317)': [4963], 'may': [4970], 'associated': [4972], 'proliferation,': [4977], 'finding': [4982], 'uncertain': [4988], 'does': [5003], 'conceivable': [5013], 'cytokine': [5020], 'playing': [5022], 'determining': [5027], 'fate': [5029], 'p42/44': [5042, 5116, 5155, 5166], 'case': [5065], 'insulin-like': [5067], '1,': [5070], 'Akt': [5071], 'responsible': [5075], 'skeletal': [5081], 'myotube': [5082], '(35Rommel': [5083], 'Bodine': [5085], 'S.C.': [5086], 'Clarke': [5087], 'Rossman': [5089], 'Nunez': [5091], 'Stitt': [5093], 'T.N.': [5094], 'Yancopoulos': [5095], 'G.D.': [5096], 'Glass': [5097], '3:': [5103], '1009-1013Crossref': [5104], '(1212)': [5107], 'endothelin-induced': [5111], 'requires': [5113], 'c-Jun': [5119], 'N-terminal': [5120], 'kinase/stress-activated': [5121], 'phosphatidylinositol': [5125], '3-kinase': [5126], 'pathways': [5127], '(36Goruppi': [5128], 'Bonventre': [5130], 'J.V.': [5131], 'Kyriakis': [5132], 'J.M.': [5133], 'EMBO': [5134], '21:': [5137], '5427-5436Crossref': [5138], '(67)': [5141], 'definite': [5148], 'evidence': [5149], 'so': [5162], 'far,': [5163], 'phosphorylation': [5164], 'clarified': [5194], 'studies.': [5197], 'summary,': [5199], 'inducing': [5222], 'completely': [5229], 'explaining': [5232], 'Blocking': [5238], 'thank': [5254, 5273], 'Drs.': [5255], 'Hideharu': [5256], 'Abe': [5257], '(Tokushima': [5258], 'University)': [5259, 5277], 'Daisuke': [5261], 'Koya': [5262], '(Shiga': [5263], 'Medical': [5266], 'Science)': [5267], 'helpful': [5269], 'comments.': [5270], 'Toshiko': [5274], 'Hori': [5275], '(Kyoto': [5276], 'Hideo': [5279], 'Uchiyama': [5280], '(Taigenkai': [5281], 'Hospital)': [5282], 'excellent': [5284], 'technical': [5285], 'assistance.': [5286]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2064741730', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-13T13:13:50.199810', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
