Polybrene and interleukin‐4: two opposing factors for retroviral transduction of bone‐marrow‐derived dendritic cells

Name: Work Video:
Duration: 3 min 30 s
Stéphanie Fresnay; David Chalmers; Christophe Ferrand; Christine Colombain; I Newton; Véronique Yerly‐Motta; Agnès Lienard; P Darodes de Tailly; Patrick Hervé; Pierre Tiberghien; Philippe Saas
{'id': 'https://openalex.org/W2064238862', 'doi': 'https://doi.org/10.1002/jgm.311', 'title': 'Polybrene and interleukin‐4: two opposing factors for retroviral transduction of bone‐marrow‐derived dendritic cells', 'display_name': 'Polybrene and interleukin‐4: two opposing factors for retroviral transduction of bone‐marrow‐derived dendritic cells', 'publication_year': 2002, 'publication_date': '2002-07-12', 'ids': {'openalex': 'https://openalex.org/W2064238862', 'doi': 'https://doi.org/10.1002/jgm.311', 'mag': '2064238862', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12439852'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jgm.311', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S91057606', 'display_name': 'The Journal of Gene Medicine', 'issn_l': '1099-498X', 'issn': ['1099-498X', '1521-2254'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5110417707', 'display_name': 'Stéphanie Fresnay', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90843659', 'display_name': 'Université de franche-comté', 'ror': 'https://ror.org/03pcc9z86', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I90843659']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Stéphanie Fresnay', 'raw_affiliation_strings': ['Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France', 'institution_ids': ['https://openalex.org/I90843659', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020848302', 'display_name': 'David Chalmers', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I90843659', 'display_name': 'Université de franche-comté', 'ror': 'https://ror.org/03pcc9z86', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I90843659']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'David E. Chalmers', 'raw_affiliation_strings': ['Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France', 'institution_ids': ['https://openalex.org/I154526488', 'https://openalex.org/I90843659']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078237337', 'display_name': 'Christophe Ferrand', 'orcid': 'https://orcid.org/0000-0003-0119-3919'}, 'institutions': [{'id': 'https://openalex.org/I90843659', 'display_name': 'Université de franche-comté', 'ror': 'https://ror.org/03pcc9z86', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I90843659']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Christophe Ferrand', 'raw_affiliation_strings': ['Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France', 'institution_ids': ['https://openalex.org/I90843659', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020721608', 'display_name': 'Christine Colombain', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90843659', 'display_name': 'Université de franche-comté', 'ror': 'https://ror.org/03pcc9z86', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I90843659']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Christine Colombain', 'raw_affiliation_strings': ['Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France', 'institution_ids': ['https://openalex.org/I90843659', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053602429', 'display_name': 'I Newton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90843659', 'display_name': 'Université de franche-comté', 'ror': 'https://ror.org/03pcc9z86', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I90843659']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Isobel Newton', 'raw_affiliation_strings': ['Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France', 'institution_ids': ['https://openalex.org/I90843659', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086141201', 'display_name': 'Véronique Yerly‐Motta', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90843659', 'display_name': 'Université de franche-comté', 'ror': 'https://ror.org/03pcc9z86', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I90843659']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Véronique Yerly‐Motta', 'raw_affiliation_strings': ['Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France', 'institution_ids': ['https://openalex.org/I90843659', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050466153', 'display_name': 'Agnès Lienard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90843659', 'display_name': 'Université de franche-comté', 'ror': 'https://ror.org/03pcc9z86', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I90843659']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Agnès Lienard', 'raw_affiliation_strings': ['Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France', 'institution_ids': ['https://openalex.org/I90843659', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034795615', 'display_name': 'P Darodes de Tailly', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90843659', 'display_name': 'Université de franche-comté', 'ror': 'https://ror.org/03pcc9z86', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I90843659']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Patrick Darodes de Tailly', 'raw_affiliation_strings': ['Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France', 'institution_ids': ['https://openalex.org/I90843659', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103457447', 'display_name': 'Patrick Hervé', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90843659', 'display_name': 'Université de franche-comté', 'ror': 'https://ror.org/03pcc9z86', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I90843659']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Patrick Hervé', 'raw_affiliation_strings': ['Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France', 'institution_ids': ['https://openalex.org/I90843659', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029675225', 'display_name': 'Pierre Tiberghien', 'orcid': 'https://orcid.org/0000-0002-9310-8322'}, 'institutions': [{'id': 'https://openalex.org/I90843659', 'display_name': 'Université de franche-comté', 'ror': 'https://ror.org/03pcc9z86', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I90843659']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Pierre Tiberghien', 'raw_affiliation_strings': ['Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France', 'institution_ids': ['https://openalex.org/I90843659', 'https://openalex.org/I154526488']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5065004424', 'display_name': 'Philippe Saas', 'orcid': 'https://orcid.org/0000-0002-8857-9939'}, 'institutions': [{'id': 'https://openalex.org/I90843659', 'display_name': 'Université de franche-comté', 'ror': 'https://ror.org/03pcc9z86', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I90843659']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Philippe Saas', 'raw_affiliation_strings': ['Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France'], 'affiliations': [{'raw_affiliation_string': 'Etablissement Français du Sang de Bourgogne Franche‐Comté, INSERM E0119, UPRES MEN2284, Université de Franche‐Comté, F‐25020 Besançon cedex, France', 'institution_ids': ['https://openalex.org/I90843659', 'https://openalex.org/I154526488']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4070, 'currency': 'USD', 'value_usd': 4070, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.202, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 6, 'citation_normalized_percentile': {'value': 0.442855, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 75, 'max': 76}, 'biblio': {'volume': '4', 'issue': '6', 'first_page': '601', 'last_page': '612'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10580', 'display_name': 'Immunotherapy and Immune Responses', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transduction', 'display_name': 'Transduction (biophysics)', 'score': 0.647887}, {'id': 'https://openalex.org/keywords/protamine-sulfate', 'display_name': 'Protamine sulfate', 'score': 0.4412763}, {'id': 'https://openalex.org/keywords/interleukin-3', 'display_name': 'Interleukin 3', 'score': 0.42544043}], 'concepts': [{'id': 'https://openalex.org/C15152581', 'wikidata': 'https://www.wikidata.org/wiki/Q7833966', 'display_name': 'Transduction (biophysics)', 'level': 2, 'score': 0.647887}, {'id': 'https://openalex.org/C2780007613', 'wikidata': 'https://www.wikidata.org/wiki/Q546523', 'display_name': 'Bone marrow', 'level': 2, 'score': 0.52855194}, {'id': 'https://openalex.org/C32470452', 'wikidata': 'https://www.wikidata.org/wiki/Q2298489', 'display_name': 'Viral vector', 'level': 4, 'score': 0.5276928}, {'id': 'https://openalex.org/C111599444', 'wikidata': 'https://www.wikidata.org/wiki/Q213901', 'display_name': 'Genetic enhancement', 'level': 3, 'score': 0.52629757}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5244144}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.5078259}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.46545464}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.4516895}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.44670874}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.445024}, {'id': 'https://openalex.org/C2779354726', 'wikidata': 'https://www.wikidata.org/wiki/Q22075855', 'display_name': 'Protamine sulfate', 'level': 4, 'score': 0.4412763}, {'id': 'https://openalex.org/C131665280', 'wikidata': 'https://www.wikidata.org/wiki/Q14866169', 'display_name': 'Interleukin 3', 'level': 5, 'score': 0.42544043}, {'id': 'https://openalex.org/C135983454', 'wikidata': 'https://www.wikidata.org/wiki/Q2790163', 'display_name': 'Gene delivery', 'level': 4, 'score': 0.41648257}, {'id': 'https://openalex.org/C2780835560', 'wikidata': 'https://www.wikidata.org/wiki/Q5449573', 'display_name': 'Protamine', 'level': 3, 'score': 0.3989339}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.33615482}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.33582675}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.31164902}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.29269186}, {'id': 'https://openalex.org/C2777557582', 'wikidata': 'https://www.wikidata.org/wiki/Q190016', 'display_name': 'Heparin', 'level': 2, 'score': 0.27654302}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.23753658}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.23420474}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16726622}, {'id': 'https://openalex.org/C67662055', 'wikidata': 'https://www.wikidata.org/wiki/Q1047791', 'display_name': 'Antigen-presenting cell', 'level': 4, 'score': 0.12996212}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.10967931}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09308261}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001854', 'descriptor_name': 'Bone Marrow Cells', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': True}, {'descriptor_ui': 'D003713', 'descriptor_name': 'Dendritic Cells', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': True}, {'descriptor_ui': 'D006583', 'descriptor_name': 'Hexadimethrine Bromide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015847', 'descriptor_name': 'Interleukin-4', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D012190', 'descriptor_name': 'Retroviridae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014161', 'descriptor_name': 'Transduction, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001854', 'descriptor_name': 'Bone Marrow Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002455', 'descriptor_name': 'Cell Division', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018920', 'descriptor_name': 'Coculture Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003713', 'descriptor_name': 'Dendritic Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006583', 'descriptor_name': 'Hexadimethrine Bromide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015847', 'descriptor_name': 'Interleukin-4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007959', 'descriptor_name': 'Lymphocyte Culture Test, Mixed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008815', 'descriptor_name': 'Mice, Inbred Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012190', 'descriptor_name': 'Retroviridae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jgm.311', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S91057606', 'display_name': 'The Journal of Gene Medicine', 'issn_l': '1099-498X', 'issn': ['1099-498X', '1521-2254'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12439852', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 48, 'referenced_works': ['https://openalex.org/W1515198913', 'https://openalex.org/W1520358531', 'https://openalex.org/W1562206634', 'https://openalex.org/W1564489838', 'https://openalex.org/W1571190010', 'https://openalex.org/W1627965833', 'https://openalex.org/W1661544713', 'https://openalex.org/W1790202563', 'https://openalex.org/W1962927130', 'https://openalex.org/W1972758309', 'https://openalex.org/W1973705988', 'https://openalex.org/W1975284062', 'https://openalex.org/W1987113826', 'https://openalex.org/W1998609613', 'https://openalex.org/W2000286082', 'https://openalex.org/W2021736875', 'https://openalex.org/W2031454462', 'https://openalex.org/W2035695825', 'https://openalex.org/W2041026285', 'https://openalex.org/W2047133712', 'https://openalex.org/W2066964346', 'https://openalex.org/W2066980743', 'https://openalex.org/W2070190810', 'https://openalex.org/W2077648553', 'https://openalex.org/W2079363783', 'https://openalex.org/W2092235636', 'https://openalex.org/W2092493190', 'https://openalex.org/W2094373273', 'https://openalex.org/W2105007068', 'https://openalex.org/W2107857115', 'https://openalex.org/W2111356575', 'https://openalex.org/W2113586748', 'https://openalex.org/W2116286338', 'https://openalex.org/W2117216774', 'https://openalex.org/W2131761283', 'https://openalex.org/W2133071747', 'https://openalex.org/W2144868114', 'https://openalex.org/W2145850608', 'https://openalex.org/W2157017096', 'https://openalex.org/W2169546809', 'https://openalex.org/W2171653261', 'https://openalex.org/W2199770196', 'https://openalex.org/W2270284384', 'https://openalex.org/W2315032149', 'https://openalex.org/W2418889500', 'https://openalex.org/W26446316', 'https://openalex.org/W4241686679', 'https://openalex.org/W4247590927'], 'related_works': ['https://openalex.org/W4236345797', 'https://openalex.org/W2422628669', 'https://openalex.org/W2415002397', 'https://openalex.org/W2168822023', 'https://openalex.org/W2045697990', 'https://openalex.org/W2027795091', 'https://openalex.org/W2023619243', 'https://openalex.org/W2008505741', 'https://openalex.org/W1969645821', 'https://openalex.org/W1785141706'], 'abstract_inverted_index': {'Abstract': [0], 'Background': [1], 'Gene': [2], 'transfer': [3], 'using': [4, 58, 151], 'retroviral': [5, 72, 82, 117, 231], 'transduction': [6], 'offers': [7], 'the': [8, 78, 87, 103, 122, 141, 160, 199, 223, 235, 244], 'advantage': [9, 41], 'of': [10, 26, 42, 89, 102, 116, 119, 124, 143, 225, 237, 243], 'long‐term': [11], 'transgene': [12, 196], 'expression': [13, 197], 'in': [14, 33, 37, 86, 121, 159, 174, 198, 204, 258], 'developing': [15], 'strategies': [16], 'that': [17, 171, 192], 'use': [18, 224], 'dendritic': [19], 'cells': [20, 67, 105], '(DCs)': [21], 'for': [22], 'immunotherapy.': [23], 'The': [24, 66], 'goal': [25], 'this': [27, 247], 'study': [28], 'was': [29, 129, 148], 'to': [30, 39, 131, 135, 214, 230], 'infect': [31], 'DCs': [32, 50, 120, 137, 172, 193], 'an': [34, 184, 240], 'immature': [35], 'state': [36], 'order': [38], 'take': [40], 'their': [43], 'proliferating': [44], 'and': [45, 95, 99, 138, 166, 216, 234], 'tolerogenic': [46], 'potential.': [47], 'Methods': [48], 'Immature': [49], 'were': [51, 68, 106], 'generated': [52, 173], 'from': [53], 'murine': [54, 136, 218], 'bone': [55], 'marrow': [56], '(BM)': [57], 'either': [59], 'GM‐CSF': [60, 63, 175], 'alone': [61], 'or': [62, 74], 'plus': [64, 176], 'IL‐4.': [65], 'transduced': [69, 104], 'directly': [70, 133], 'with': [71, 77, 183], 'supernatants': [73], 'by': [75, 156], 'co‐culture': [76], 'GP': [79], '+': [80], 'E‐86': [81], 'packaging': [83, 201], 'cell': [84, 202], 'line': [85, 203], 'presence': [88, 123], 'two': [90], 'different': [91], 'cationic': [92, 127], 'polymers:': [93], 'polybrene': [94], 'protamine': [96, 152, 226], 'sulfate.': [97, 153], 'Phenotypic': [98], 'functional': [100], 'characterization': [101], 'then': [107], 'performed.': [108], 'Results': [109], 'Our': [110], 'results': [111], 'show': [112], 'a': [113, 179, 205], 'low': [114], 'efficiency': [115], 'infection': [118], 'polybrene.': [125], 'This': [126, 146, 221], 'polymer': [128], 'found': [130, 170], 'be': [132], 'cytotoxic': [134], 'thus': [139], 'favored': [140], 'growth': [142], 'contaminating': [144], 'macrophages.': [145], 'effect': [147], 'not': [149], 'observed': [150], 'Furthermore,': [154], 'stimulation': [155], 'IL‐4': [157, 177, 238], 'early': [158, 241], 'culture': [161], 'increased': [162], 'DC': [163, 251], 'differentiation,': [164], 'proliferation': [165], 'transduction.': [167], 'However,': [168], 'we': [169, 190], 'presented': [178], 'more': [180], 'mature': [181], 'phenotype': [182], 'enhanced': [185], 'allogeneic': [186], 'stimulating': [187], 'activity.': [188], 'Finally,': [189], 'showed': [191], 'themselves': [194], 'down‐regulated': [195], 'co‐cultured': [200], 'promoter‐dependent': [206], 'manner.': [207], 'Conclusions': [208], 'We': [209], 'have': [210, 255], 'defined': [211], 'optimal': [212], 'conditions': [213], 'generate': [215], 'transduce': [217], 'BM‐derived': [219], 'DCs.': [220], 'included:': [222], 'sulfate': [227], 'during': [228], 'exposure': [229], 'infectious': [232], 'supernatant': [233], 'addition': [236], 'at': [239], 'stage': [242], 'culture.': [245], 'Nevertheless,': [246], 'cytokine': [248], 'also': [249], 'induced': [250], 'maturation.': [252], 'These': [253], 'findings': [254], 'potential': [256], 'implications': [257], 'experimental': [259], 'gene': [260], 'therapy.': [261], 'Copyright': [262], '©': [263], '2002': [264], 'John': [265], 'Wiley': [266], '&amp;': [267], 'Sons,': [268], 'Ltd.': [269]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2064238862', 'counts_by_year': [], 'updated_date': '2024-12-14T19:08:31.583911', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
