Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1969645821', 'doi': 'https://doi.org/10.1002/ccd.1810160403', 'title': 'Complement activation from protamine sulfate administration after coronary angiography', 'display_name': 'Complement activation from protamine sulfate administration after coronary angiography', 'publication_year': 1989, 'publication_date': '1989-04-01', 'ids': {'openalex': 'https://openalex.org/W1969645821', 'doi': 'https://doi.org/10.1002/ccd.1810160403', 'mag': '1969645821', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2785004'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/ccd.1810160403', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S138728561', 'display_name': 'Catheterization and Cardiovascular Diagnosis', 'issn_l': '0098-6569', 'issn': ['0098-6569', '1097-0304'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5016300985', 'display_name': 'Roger L. Click', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Roger L. Click', 'raw_affiliation_strings': ['Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic Rochester, MN 55905.'], 'affiliations': [{'raw_affiliation_string': 'Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic Rochester, MN 55905.', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109081267', 'display_name': 'Henry A. Homburger', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Henry A. Homburger', 'raw_affiliation_strings': ['Mayo Clinic, and Mayo Foundation, Rochester, Minnesota'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic, and Mayo Foundation, Rochester, Minnesota', 'institution_ids': ['https://openalex.org/I1330342723']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5109122558', 'display_name': 'Alfred A. Bove', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1330342723', 'display_name': 'Mayo Clinic', 'ror': 'https://ror.org/02qp3tb03', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1330342723']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alfred A. Bove', 'raw_affiliation_strings': ['Mayo Clinic, and Mayo Foundation, Rochester, Minnesota'], 'affiliations': [{'raw_affiliation_string': 'Mayo Clinic, and Mayo Foundation, Rochester, Minnesota', 'institution_ids': ['https://openalex.org/I1330342723']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.35, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 10, 'citation_normalized_percentile': {'value': 0.732999, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 79, 'max': 80}, 'biblio': {'volume': '16', 'issue': '4', 'first_page': '221', 'last_page': '225'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11217', 'display_name': 'Cardiac Arrhythmias and Treatments', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11217', 'display_name': 'Cardiac Arrhythmias and Treatments', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12352', 'display_name': 'Heparin-Induced Thrombocytopenia and Thrombosis', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10285', 'display_name': 'Venous Thromboembolism Diagnosis and Management', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2724', 'display_name': 'Internal Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/protamine-sulfate', 'display_name': 'Protamine sulfate', 'score': 0.9844643}], 'concepts': [{'id': 'https://openalex.org/C2779354726', 'wikidata': 'https://www.wikidata.org/wiki/Q22075855', 'display_name': 'Protamine sulfate', 'level': 4, 'score': 0.9844643}, {'id': 'https://openalex.org/C2780835560', 'wikidata': 'https://www.wikidata.org/wiki/Q5449573', 'display_name': 'Protamine', 'level': 3, 'score': 0.9690815}, {'id': 'https://openalex.org/C2777557582', 'wikidata': 'https://www.wikidata.org/wiki/Q190016', 'display_name': 'Heparin', 'level': 2, 'score': 0.8867216}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.7908667}, {'id': 'https://openalex.org/C2781362458', 'wikidata': 'https://www.wikidata.org/wiki/Q1588755', 'display_name': 'Thrombus', 'level': 2, 'score': 0.5417242}, {'id': 'https://openalex.org/C111684460', 'wikidata': 'https://www.wikidata.org/wiki/Q334848', 'display_name': 'Complement system', 'level': 3, 'score': 0.5159536}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.48716065}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.47780877}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.1836018}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000706', 'descriptor_name': 'Anaphylatoxins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D003167', 'descriptor_name': 'Complement Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D017023', 'descriptor_name': 'Coronary Angiography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D011479', 'descriptor_name': 'Protamines', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': True}, {'descriptor_ui': 'D000706', 'descriptor_name': 'Anaphylatoxins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000792', 'descriptor_name': 'Angiography', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003167', 'descriptor_name': 'Complement Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003176', 'descriptor_name': 'Complement C3', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D003176', 'descriptor_name': 'Complement C3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015926', 'descriptor_name': 'Complement C3a', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003181', 'descriptor_name': 'Complement C4', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D003181', 'descriptor_name': 'Complement C4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015934', 'descriptor_name': 'Complement C4a', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007022', 'descriptor_name': 'Hypotension', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D007022', 'descriptor_name': 'Hypotension', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011479', 'descriptor_name': 'Protamines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D011479', 'descriptor_name': 'Protamines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/ccd.1810160403', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S138728561', 'display_name': 'Catheterization and Cardiovascular Diagnosis', 'issn_l': '0098-6569', 'issn': ['0098-6569', '1097-0304'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2785004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.72, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W131580119', 'https://openalex.org/W131594883', 'https://openalex.org/W1483858132', 'https://openalex.org/W1523472415', 'https://openalex.org/W1974379678', 'https://openalex.org/W1997336413', 'https://openalex.org/W2002917521', 'https://openalex.org/W2006738885', 'https://openalex.org/W2011297170', 'https://openalex.org/W2013545198', 'https://openalex.org/W2015136873', 'https://openalex.org/W2049223593', 'https://openalex.org/W2058283393', 'https://openalex.org/W2076874997', 'https://openalex.org/W2081956070', 'https://openalex.org/W2087444055', 'https://openalex.org/W2091924005', 'https://openalex.org/W2125725046', 'https://openalex.org/W2129178261', 'https://openalex.org/W2149565536', 'https://openalex.org/W2157823999', 'https://openalex.org/W2284120099', 'https://openalex.org/W2330568965', 'https://openalex.org/W2341630418', 'https://openalex.org/W2399127344', 'https://openalex.org/W2417791398', 'https://openalex.org/W2419601768', 'https://openalex.org/W2424463250', 'https://openalex.org/W2436417185', 'https://openalex.org/W2465859164', 'https://openalex.org/W33405976', 'https://openalex.org/W4205121498', 'https://openalex.org/W4239637345', 'https://openalex.org/W4293262123', 'https://openalex.org/W4294491515', 'https://openalex.org/W588433371', 'https://openalex.org/W74848718'], 'related_works': ['https://openalex.org/W2462737584', 'https://openalex.org/W2415002397', 'https://openalex.org/W2411036744', 'https://openalex.org/W2328522296', 'https://openalex.org/W2111990318', 'https://openalex.org/W2027795091', 'https://openalex.org/W2025062353', 'https://openalex.org/W2023619243', 'https://openalex.org/W1980832026', 'https://openalex.org/W1964253022'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'cause': [2], 'of': [3, 7], 'hypotension': [4, 125], 'after': [5, 47, 100, 119], 'reversal': [6, 145], 'heparin': [8, 144], 'by': [9, 26, 146], 'protamine': [10, 36, 53, 66, 79, 101, 115, 147], 'has': [11], 'not': [12, 77, 149], 'been': [13], 'well': [14, 127], 'defined.': [15], 'In': [16, 50], 'this': [17], 'study': [18], 'we': [19], 'evaluated': [20], 'complement': [21, 110], 'activation': [22], '(C3a': [23], 'and': [24, 41, 46, 131, 134], 'C4a)': [25], 'the': [27, 63, 108], 'heparin‐protamine': [28], 'complex': [29], 'in': [30, 60, 73, 98, 141], '46': [31], 'consecutive': [32], 'patients': [33, 51, 74], '(40': [34], 'received': [35], 'sulfate': [37, 67, 80, 102, 116], 'to': [38, 137], 'reverse': [39], 'heparin,': [40], 'six': [42], 'did': [43, 76], 'not)': [44], 'during': [45], 'coronary': [48, 120, 138], 'angiography.': [49, 121], 'receiving': [52], 'sulfate,': [54], 'there': [55], 'was': [56], 'a': [57], 'significant': [58, 96], 'increase': [59], 'C3a': [61], 'over': [62], 'value': [64], 'before': [65], 'administration': [68], '(': [69, 81], 'P': [70, 82], '<.001)': [71], 'or': [72], 'who': [75], 'receive': [78], '<.05):': [83], '807': [84], '±': [85, 90], '100': [86], 'ng/ml': [87], 'vs.': [88], '274': [89], '75': [91], 'ng/ml.': [92], 'There': [93], 'were': [94], 'no': [95], 'changes': [97], 'C4a': [99], 'administration.': [103], 'These': [104], 'results': [105], 'indicate': [106], 'that': [107], 'alternate': [109], 'pathway': [111], 'is': [112, 117], 'activated': [113], 'when': [114], 'administered': [118], 'This': [122], 'may': [123, 135], 'induce': [124], 'as': [126, 128], 'platelet': [129], 'aggregation': [130], 'thrombus': [132], 'formation': [133], 'contribute': [136], 'instability.': [139], 'Therefore,': [140], 'unstable': [142], 'patients,': [143], 'should': [148], 'be': [150], 'done': [151], 'routinely.': [152]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969645821', 'counts_by_year': [{'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-11T11:42:25.459405', 'created_date': '2016-06-24'}