Title: Emerging role of angiotensin-converting enzyme inhibitors in cardiac and vascular protection.
Abstract: HomeCirculationVol. 90, No. 4Emerging role of angiotensin-converting enzyme inhibitors in cardiac and vascular protection. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyRedditDiggEmail Jump toFree AccessAbstractPDF/EPUBEmerging role of angiotensin-converting enzyme inhibitors in cardiac and vascular protection. E M Lonn, S Yusuf, P Jha, T J Montague, K K Teo, C R Benedict and B Pitt E M LonnE M Lonn Division of Cardiology and Preventive Cardiology, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada. , S YusufS Yusuf Division of Cardiology and Preventive Cardiology, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada. , P JhaP Jha Division of Cardiology and Preventive Cardiology, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada. , T J MontagueT J Montague Division of Cardiology and Preventive Cardiology, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada. , K K TeoK K Teo Division of Cardiology and Preventive Cardiology, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada. , C R BenedictC R Benedict Division of Cardiology and Preventive Cardiology, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada. and B PittB Pitt Division of Cardiology and Preventive Cardiology, Hamilton Civic Hospitals Research Centre, McMaster University, Ontario, Canada. Originally published1 Oct 1994https://doi.org/10.1161/01.CIR.90.4.2056Circulation. 1994;90:2056–2069 Previous Back to top Next FiguresReferencesRelatedDetailsCited By Montañez-Fernández J, Cueto-Manzano A, Rojas-Campos E, Vásquez-Jiménez J and Ordaz-Medina S (2021) Soluble Triggering Receptor on Myeloid Cell-1 and its Predictive Factors in Patients With End-Stage Kidney Disease on Hemodialysis, ASAIO Journal, 10.1097/MAT.0000000000001541, 68:4, (605-609), Online publication date: 1-Apr-2022. Luzum J, EDOKOBI O, DORSCH M, PETERSON E, LIU B, GUI H, WILLIAMS L and LANFEAR D (2022) Survival Association of Angiotensin Inhibitors in Heart Failure With Reduced Ejection Fraction: Comparisons Using Self-Identified Race and Genomic Ancestry, Journal of Cardiac Failure, 10.1016/j.cardfail.2021.08.007, 28:2, (215-225), Online publication date: 1-Feb-2022. DeCarolis D, Gravely A, Olney C and Ishani A (2022) Impact of Antihypertensive Drug Class on Outcomes in SPRINT, Hypertension, 79:5, (1112-1121), Online publication date: 1-May-2022. Park S, Kim Y, Ann S, Park H, Suh J, Roh J, Cho Y, Han S and Park G (2021) Angiotensin-Converting Enzyme Inhibitor–based Versus Angiotensin Receptor Blocker–based Optimal Medical Therapy After Percutaneous Coronary Intervention: A Nationwide Cohort Study, Journal of Cardiovascular Pharmacology, 10.1097/FJC.0000000000000930, 77:1, (61-68) Kangussu L, Marzano L, Souza C, Dantas C, Miranda A and Simões e Silva A The Renin-Angiotensin System and the Cerebrovascular Diseases: Experimental and Clinical Evidence, Protein & Peptide Letters, 10.2174/0929866527666191218091823, 27:6, (463-475) Wang B, Pan D, Kou S, Lin Z and Shi J (2020) Exploring the binding interaction between bovine serum albumin and perindopril as well as influence of metal ions using multi-spectroscopic, molecular docking and DFT calculation, Chemical Physics, 10.1016/j.chemphys.2019.110641, 530, (110641), Online publication date: 1-Feb-2020. Aikawa T, Takeda A, Oyama-Manabe N, Naya M, Yamazawa H, Koyanagawa K, Ito Y and Anzai T (2018) Progressive left ventricular dysfunction and myocardial fibrosis in Duchenne and Becker muscular dystrophy: a longitudinal cardiovascular magnetic resonance study, Pediatric Cardiology, 10.1007/s00246-018-2046-x, 40:2, (384-392), Online publication date: 1-Feb-2019. Khatib R (2018) OBSOLETE: Pharmacology of Medications Used in the Treatment of Atherosclerotic Cardiovascular Disease Reference Module in Biomedical Sciences, 10.1016/B978-0-12-801238-3.99756-3, . Cambier S, Røgeberg M, Georgantzopoulou A, Serchi T, Karlsson C, Verhaegen S, Iversen T, Guignard C, Kruszewski M, Hoffmann L, Audinot J, Ropstad E and Gutleb A (2018) Fate and effects of silver nanoparticles on early life-stage development of zebrafish (Danio rerio) in comparison to silver nitrate, Science of The Total Environment, 10.1016/j.scitotenv.2017.08.115, 610-611, (972-982), Online publication date: 1-Jan-2018. Khatib R and Wilson F (2018) Pharmacology of Medications Used in the Treatment of Atherosclerotic Cardiovascular Disease Encyclopedia of Cardiovascular Research and Medicine, 10.1016/B978-0-12-809657-4.99756-4, (68-88), . Watson K, Guo Y and Sahni S (2018) Secondary Prevention of Coronary Artery Disease Chronic Coronary Artery Disease, 10.1016/B978-0-323-42880-4.00030-3, (479-487), . Bath P, Appleton J, Krishnan K and Sprigg N (2018) Blood Pressure in Acute Stroke, Stroke, 49:7, (1784-1790), Online publication date: 1-Jul-2018. Krüger W (2017) Acute Heart Failure Syndromes Acute Heart Failure, 10.1007/978-3-319-54973-6_2, (81-162), . Cassina M, Cagnoli G, Zuccarello D, Di Gianantonio E and Clementi M (2017) Human teratogens and genetic phenocopies. Understanding pathogenesis through human genes mutation, European Journal of Medical Genetics, 10.1016/j.ejmg.2016.09.011, 60:1, (22-31), Online publication date: 1-Jan-2017. Shodehinde S, Oyeleye S, Olasehinde T, Adebayo A, Oboh G and Boligon A (2017) Lasianthera Africana leaves inhibits α-amylase α-glucosidase, angiotensin-I converting enzyme activities and Fe2+-induced oxidative damage in pancreas and kidney homogenates, Oriental Pharmacy and Experimental Medicine, 10.1007/s13596-017-0256-z, 17:1, (41-49), Online publication date: 1-Mar-2017. Deng B, Ni X, Zhai Z, Tang T, Tan C, Yan Y, Deng J and Yin Y (2017) New Quantitative Structure–Activity Relationship Model for Angiotensin-Converting Enzyme Inhibitory Dipeptides Based on Integrated Descriptors, Journal of Agricultural and Food Chemistry, 10.1021/acs.jafc.7b03367, 65:44, (9774-9781), Online publication date: 8-Nov-2017. Hedner T, Kjeldsen S, Narkiewicz K and Oparil S (2016) The polypill: an emerging treatment alternative for secondary prevention of cardiovascular disease, Blood Pressure, 10.3109/08037051.2016.1139324, 25:5, (276-279), Online publication date: 2-Sep-2016. Mazza A, Ravenni R, Armigliato M, Rossetti C, Schiavon L, Fiorini F, Rigatelli G, Ramazzina E and Casiglia E (2016) Mood Disorders in Uncontrolled Hypertension Despite Multiple Anti-Hypertensive Medications: Searching for a Link, High Blood Pressure & Cardiovascular Prevention, 10.1007/s40292-015-0128-x, 23:1, (41-46), Online publication date: 1-Mar-2016. Li H, Spagnol G, Zheng L, Stauch K and Sorgen P (2016) Regulation of Connexin43 Function and Expression by Tyrosine Kinase 2, Journal of Biological Chemistry, 10.1074/jbc.M116.727008, 291:30, (15867-15880), Online publication date: 1-Jul-2016. Padala S, Sidhu M and Boden W (2016) Stable Ischemic Heart Disease PanVascular Medicine, 10.1007/978-3-642-37393-0_70-2, (1-70), . Appleton J, Sprigg N and Bath P (2016) Blood pressure management in acute stroke, BMJ, 10.1136/svn-2016-000020, 1:2, (72-82), Online publication date: 1-Jun-2016. Mishra A, Srivastava A, Kumar S, Mittal T, Garg N, Agarwal S, Pande S and Mittal B (2015) Role of angiotensin II type I (AT1 A1166C) receptor polymorphism in susceptibility of left ventricular dysfunction, Indian Heart Journal, 10.1016/j.ihj.2015.04.013, 67:3, (214-221), Online publication date: 1-May-2015. Padala S, Sidhu M and Boden W (2015) Stable Ischemic Heart Disease Stable Ischemic Heart Disease PanVascular Medicine, 10.1007/978-3-642-37078-6_70, (2109-2172), . Liang B and Su J (2015) Involvement of Renin-Angiotensin System Inhibition, the Potential Risk of Danshen in the Treatment of Pregnancy-Induced Hypertension, Phytotherapy Research, 10.1002/ptr.5383, 29:9, (1421-1422), Online publication date: 1-Sep-2015. Wang F, Lu X, Liu M, Feng Y, Zhou S and Yang T (2015) Renal medullary (pro)renin receptor contributes to angiotensin II-induced hypertension in rats via activation of the local renin–angiotensin system, BMC Medicine, 10.1186/s12916-015-0514-1, 13:1, Online publication date: 1-Dec-2015. Imbalzano E, Scarpelli M, Mandraffino G, Creazzo M, Lizio G, Trapani G, Dattilo G, Dalbeni A, Tomasello C, Sardo M and Saitta A (2014) Combination therapy with aliskiren versus ramipril or losartan added to conventional therapy in patients with type 2 diabetes mellitus, uncontrolled hypertension and microalbuminuria, Journal of the Renin-Angiotensin-Aldosterone System, 10.1177/1470320314530018, 16:4, (956-964), Online publication date: 1-Dec-2015. van der Leeuw J, Oemrawsingh R, van der Graaf Y, Brugts J, Deckers J, Bertrand M, Fox K, Ferrari R, Remme W, Simoons M, Boersma E and Visseren F (2015) Prediction of absolute risk reduction of cardiovascular events with perindopril for individual patients with stable coronary artery disease — Results from EUROPA, International Journal of Cardiology, 10.1016/j.ijcard.2014.12.046, 182, (194-199), Online publication date: 1-Mar-2015. Hong Y, Jeong M, Cho K, Kim M, Lee K, Kim K, Kim H, Jeong H, Park K, Sim D, Kim J, Ahn Y, Cho J, Park J, Kim S and Kang J (2015) Impact of renal function on changes of plaque characteristics in non-intervened coronary segments after rosuvastatin treatment in patients with angina pectoris and hypertension, International Journal of Cardiology, 10.1016/j.ijcard.2015.03.331, 187, (286-287), Online publication date: 1-May-2015. Hong Y, Jeong M, Kim M, Kim W, Kim H, Park K, Sim D, Kim J, Ahn Y, Cho J and Park J (2015) Predictors of Plaque Progression in Hypertensive Angina Patients with Achieved Low-Density Lipoprotein Cholesterol Less Than 70 mg/dL after Rosuvastatin Treatment, Chonnam Medical Journal, 10.4068/cmj.2015.51.3.120, 51:3, (120), . Armstrong E, Chen D, Singh G, Amsterdam E and Laird J (2015) Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use is associated with reduced major adverse cardiovascular events among patients with critical limb ischemia, Vascular Medicine, 10.1177/1358863X15574321, 20:3, (237-244), Online publication date: 1-Jun-2015. Ortolani P, Di Bartolomeo S, Marino M, Vagnarelli F, Guastaroba P, Rapezzi C and De Palma R (2015) Adherence to agents acting on the renin–angiotensin system in secondary prevention of non-fatal myocardial infarction: a self-controlled case-series study, European Heart Journal - Cardiovascular Pharmacotherapy, 10.1093/ehjcvp/pvv028, 1:4, (254-259), Online publication date: 1-Oct-2015. Khan A, Sheikh M, Kaw D, Cooper C and Khouri S (2014) Prevalence and factors associated with left ventricular remodeling in renal artery stenosis, Journal of the American Society of Hypertension, 10.1016/j.jash.2014.01.008, 8:4, (254-261), Online publication date: 1-Apr-2014. Chen S, Seliger S and Fried L (2014) Complete inhibition of the renin–angiotensin–aldosterone system; where do we stand?, Current Opinion in Nephrology and Hypertension, 10.1097/MNH.0000000000000043, 23:5, (449-455), Online publication date: 1-Sep-2014. McGrogan D, Mark D, Lee B and O'Donnell M (2014) Implementation of best medical therapy for cardiovascular risk factors in vascular surgery patients treated in a tertiary referral regional unit, International Journal of Clinical Practice, 10.1111/ijcp.12415, 68:9, (1100-1109), Online publication date: 1-Sep-2014. Evans K, Tuttle K, Folt D, Dawson T, Haller S, Brewster P, He W, Jamerson K, Dworkin L, Cutlip D, Murphy T, D’Agostino R, Henrich W and Cooper C (2014) Use of Renin-Angiotensin Inhibitors in People with Renal Artery Stenosis, Clinical Journal of the American Society of Nephrology, 10.2215/CJN.11611113, 9:7, (1199-1206), Online publication date: 7-Jul-2014. Walker A, Cubbon R and Kearney M (2014) Contemporary treatment strategies for Type 2 diabetes-related macrovascular disease, Expert Review of Endocrinology & Metabolism, 10.1586/17446651.2014.941356, 9:6, (641-658), Online publication date: 1-Nov-2014. Yang K, Bonini M and Dudley S (2014) Mitochondria and arrhythmias, Free Radical Biology and Medicine, 10.1016/j.freeradbiomed.2014.03.033, 71, (351-361), Online publication date: 1-Jun-2014. Mangiacapra F, Peace A, Di Serafino L, Pyxaras S, Bartunek J, Wyffels E, Heyndrickx G, Wijns W, De Bruyne B and Barbato E (2013) Intracoronary Enalaprilat to Reduce Microvascular Damage During Percutaneous Coronary Intervention (ProMicro) Study, Journal of the American College of Cardiology, 10.1016/j.jacc.2012.11.025, 61:6, (615-621), Online publication date: 1-Feb-2013. Majumder K, Panahi S, Kaufman S and Wu J (2013) Fried egg digest decreases blood pressure in spontaneous hypertensive rats, Journal of Functional Foods, 10.1016/j.jff.2012.10.004, 5:1, (187-194), Online publication date: 1-Jan-2013. Joyner J and Cowan J (2013) Target-directed catalytic metallodrugs, Brazilian Journal of Medical and Biological Research, 10.1590/1414-431X20133086, 46:6, (465-485), Online publication date: 1-Jun-2013. Dag O, Kaygin M, Aydin A, Limandal H, Arslan Ü, Kiymaz A, Kahraman N, Calik E and Erkut B (2013) Is Administration of Preoperative Angiotensin-Converting Enzyme Inhibitors Important for Renal Protection after Cardiac Surgery?, Renal Failure, 10.3109/0886022X.2013.777891, 35:5, (754-760), Online publication date: 1-Jun-2013. Lau W, Froehlich J, Jewell E, Montgomery D, Eng K, Shields T, Henke P and Eagle K (2013) Impact of Adding Aspirin to Beta-Blocker and Statin in High-Risk Patients Undergoing Major Vascular Surgery, Annals of Vascular Surgery, 10.1016/j.avsg.2012.12.001, 27:4, (537-545), Online publication date: 1-May-2013. Padala S, Sidhu M and Boden W (2014) Stable Ischemic Heart Disease PanVascular Medicine, 10.1007/978-3-642-37393-0_70-1, (1-70), . Monasky M, Taglieri D, Henze M, Warren C, Utter M, Soergel D, Violin J and Solaro R (2013) The β-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium, American Journal of Physiology-Heart and Circulatory Physiology, 10.1152/ajpheart.00327.2013, 305:6, (H856-H866), Online publication date: 15-Sep-2013. Bandeali S, Kayani W, Lee V, Pan W, Elayda M, Nambi V, Jneid H, Alam M, Wilson J, Birnbaum Y, Ballantyne C and Virani S (2012) Outcomes of Preoperative Angiotensin-Converting Enzyme Inhibitor Therapy in Patients Undergoing Isolated Coronary Artery Bypass Grafting, The American Journal of Cardiology, 10.1016/j.amjcard.2012.05.021, 110:7, (919-923), Online publication date: 1-Oct-2012. Butman S (2012) Consensus equals mediocrity. There, I said it!, Catheterization and Cardiovascular Interventions, 10.1002/ccd.24342, 79:4, (588-588), Online publication date: 1-Mar-2012. Joyner J, Hocharoen L and Cowan J (2012) Targeted Catalytic Inactivation of Angiotensin Converting Enzyme by Lisinopril-Coupled Transition-Metal Chelates, Journal of the American Chemical Society, 10.1021/ja208791f, 134:7, (3396-3410), Online publication date: 22-Feb-2012. Comiter C (2011) Local renin–angiotensin systems in the genitourinary tract, Naunyn-Schmiedeberg's Archives of Pharmacology, 10.1007/s00210-011-0706-y, 385:1, (13-26), Online publication date: 1-Jan-2012. Lee J, Yoon S, Cho W and Baek K (2012) A Case of Cerebellar Infarction with Renal Artery Stenosis, Korean Journal of Stroke, 10.5853/kjs.2012.14.2.82, 14:2, (82), . Fihn S, Gardin J, Abrams J, Berra K, Blankenship J, Dallas A, Douglas P, Foody J, Gerber T, Hinderliter A, King S, Kligfield P, Krumholz H, Kwong R, Lim M, Linderbaum J, Mack M, Munger M, Prager R, Sabik J, Shaw L, Sikkema J, Smith C, Smith S, Spertus J and Williams S (2012) 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease, Journal of the American College of Cardiology, 10.1016/j.jacc.2012.07.013, 60:24, (e44-e164), Online publication date: 1-Dec-2012. Collier P and McDonald K (2012) The Role of Renin Angiotensin System Intervention in Stage B Heart Failure, Heart Failure Clinics, 10.1016/j.hfc.2011.11.006, 8:2, (225-236), Online publication date: 1-Apr-2012. Fihn S, Gardin J, Abrams J, Berra K, Blankenship J, Dallas A, Douglas P, Foody J, Gerber T, Hinderliter A, King S, Kligfield P, Krumholz H, Kwong R, Lim M, Linderbaum J, Mack M, Munger M, Prager R, Sabik J, Shaw L, Sikkema J, Smith C, Smith S, Spertus J and Williams S (2012) 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease, Circulation, 126:25, (e354-e471), Online publication date: 18-Dec-2012. Grundmeijer H, Van Bentum S, Rutten F, Bakx J, Hendrick J, Bouma M, Eizenga W and Verduijn M (2011) NHG-Standaard Beleid na een doorgemaakt myocardinfarct NHG- Standaarden voor de huisarts 2011, 10.1007/978-90-313-8279-8_19, (341-359), . Seddon M and Saw J (2011) Atherosclerotic Renal Artery Stenosis: Review of Pathophysiology, Clinical Trial Evidence, and Management Strategies, Canadian Journal of Cardiology, 10.1016/j.cjca.2010.12.038, 27:4, (468-480), Online publication date: 1-Jul-2011. Sovari A, Iravanian S, Dolmatova E, Jiao Z, Liu H, Zandieh S, Kumar V, Wang K, Bernstein K, Bonini M, Duffy H and Dudley S (2011) Inhibition of c-Src Tyrosine Kinase Prevents Angiotensin II–Mediated Connexin-43 Remodeling and Sudden Cardiac Death, Journal of the American College of Cardiology, 10.1016/j.jacc.2011.07.048, 58:22, (2332-2339), Online publication date: 1-Nov-2011. Urbieta-Caceres V, Zhu X, Gibson M, Favreau F, Jordan K, Lerman A and Lerman L (2011) Reversal of Experimental Renovascular Hypertension Restores Coronary Microvascular Function and Architecture, American Journal of Hypertension, 10.1038/ajh.2010.259, 24:4, (458-465), Online publication date: 1-Apr-2011. Thompson P (2011) Plaque Passivation and Endothelial Therapy Acute Coronary Syndromes: A Companion to Braunwald's Heart Disease, 10.1016/B978-1-4160-4927-2.00026-8, (289-298), . Ruff C and Braunwald E (2010) The evolving epidemiology of acute coronary syndromes, Nature Reviews Cardiology, 10.1038/nrcardio.2010.199, 8:3, (140-147), Online publication date: 1-Mar-2011. Tropeano A, Saleh N, Hawajri N, Macquin-Mavier I and Maison P (2011) Do all antihypertensive drugs improve carotid intima-media thickness? A network meta-analysis of randomized controlled trials, Fundamental & Clinical Pharmacology, 10.1111/j.1472-8206.2010.00832.x, 25:3, (395-404), Online publication date: 1-Jun-2011. Thompson A and Thompson P (2011) Stabilizing unstable plaque in acute coronary syndromes Coronary Care Manual, 10.1016/B978-0-7295-3927-2.10045-4, (338-345), . Destro M, Cagnoni F, Dognini G, Galimberti V, Taietti C, Cavalleri C and Galli E (2011) Telmisartan: just an antihypertensive agent? A literature review, Expert Opinion on Pharmacotherapy, 10.1517/14656566.2011.632367, 12:17, (2719-2735), Online publication date: 1-Dec-2011. Üçer B, Kayıkçıoğlu Ö, Seymenoğlu G, Var A and Çam S (2011) The Relationship Between Angiotensin Converting Enzyme Insertion/deletion Polymorphism and Age-related Macular Degeneration, Ophthalmic Genetics, 10.3109/13816810.2011.560060, 32:3, (158-161), Online publication date: 1-Sep-2011. Krum H and Elsik M (2011) ACE-inhibitors and angiotensin receptor blockers Coronary Care Manual, 10.1016/B978-0-7295-3927-2.10032-6, (247-252), . Diav-Citrin O, Shechtman S, Halberstadt Y, Finkel-Pekarsky V, Wajnberg R, Arnon J, Di Gianantonio E, Clementi M and Ornoy A (2011) Pregnancy outcome after in utero exposure to angiotensin converting enzyme inhibitors or angiotensin receptor blockers, Reproductive Toxicology, 10.1016/j.reprotox.2011.02.008, 31:4, (540-545), Online publication date: 1-May-2011. Lorgis L, Richard C, Gudjoncik A, Zeller M, Buffet P, L’Huillier I and Cottin Y (2011) L’association inhibiteur de l’enzyme de conversion et antagoniste calcique. Quelle place chez le patient coronarien stable ?, Therapies, 10.2515/therapie/2010080, 66:1, (17-24), Online publication date: 1-Jan-2011. Vijayaraghavan K and Deedwania P (2011) Renin-Angiotensin-Aldosterone Blockade for Cardiovascular Disease Prevention, Cardiology Clinics, 10.1016/j.ccl.2010.11.003, 29:1, (137-156), Online publication date: 1-Feb-2011. Harley C, Sander S, Zarotsky V, Cao F and Shah H (2010) Burden of illness among patients at high risk versus low risk for major cardiovascular events, Journal of Medical Economics, 10.3111/13696998.2010.496341, 13:3, (438-446), Online publication date: 1-Sep-2010. Ma T, Kam K, Yan B and Lam Y (2010) Renin-angiotensin-aldosterone system blockade for cardiovascular diseases: current status, British Journal of Pharmacology, 10.1111/j.1476-5381.2010.00750.x, 160:6, (1273-1292), Online publication date: 1-Jul-2010. Tardif J (2010) Coronary artery disease in 2010, European Heart Journal Supplements, 10.1093/eurheartj/suq014, 12:Suppl C, (C2-C10), Online publication date: 1-Aug-2010. Komatsu T, Tachibana H, Satoh Y, Ozawa M, Kunugida F and Nakamura M (2010) Relationship Between the Long-Term Preventive Effect of Combined Treatment With Antiarrhythmic Drugs Plus Angiotensin-Converting Enzyme Inhibitors and Circadian Variation in the Onset of Paroxysmal Atrial Fibrillation, International Heart Journal, 10.1536/ihj.51.331, 51:5, (331-336), . Nantel P and René de Cotret P (2010) The evolution of angiotensin blockade in the management of cardiovascular disease, Canadian Journal of Cardiology, 10.1016/S0828-282X(10)71168-5, 26, (7E-13E), Online publication date: 1-Dec-2010. Ordaz-Medina S, González-Plascencia J, Martín del Campo F, Rojas-Campos E, Montañez-Fernández J, Espinoza-Gómez F and Cueto-Manzano A (2010) Is Systemic Inflammation of Hemodialysis Patients Improved With the Use of Enalapril? Results of a Randomized, Double-Blinded, Placebo-Controlled Clinical Trial, ASAIO Journal, 10.1097/MAT.0b013e3181c1d830, 56:1, (37-41), Online publication date: 1-Jan-2010. Feringa H, Bax J, Karagiannis S, Noordzij P, van Domburg R, Klein J and Poldermans D (2009) Elderly patients undergoing major vascular surgery: Risk factors and medication associated with risk reduction, Archives of Gerontology and Geriatrics, 10.1016/j.archger.2007.11.003, 48:1, (116-120), Online publication date: 1-Jan-2009. Gao G and Dudley S (2009) Redox Regulation, NF-κB, and Atrial Fibrillation, Antioxidants & Redox Signaling, 10.1089/ars.2009.2595, 11:9, (2265-2277), Online publication date: 1-Sep-2009. Komatsu T, Tachibana H, Sato Y, Ozawa M, Kunugida F, Orii M and Nakamura M (2009) Long-Term Efficacy of Upstream Therapy Using Angiotensin-Converting Enzyme Inhibitors and Statins in Combination With Antiarrhythmic Agents for the Treatment of Paroxysmal Atrial Fibrillation, International Heart Journal, 10.1536/ihj.50.465, 50:4, (465-476), . Sleight P (2009) Clinical evidence from ONTARGET: the value of an angiotensin II receptor blocker and an angiotensin-converting enzyme inhibitor, Journal of Hypertension, 10.1097/01.hjh.0000357905.78704.9a, 27:Suppl 5, (S23-S29), Online publication date: 1-Jul-2009. Komatsu T, Nakamura M and Okumura K (2009) , Japanese Journal of Electrocardiology, 10.5105/jse.29.117, 29:2, (117-125), . Grundmeijer H, Van Bentum S, Rutten F, Bakx J, Hendrick J, Bouma M, Eizenga W and Verduijn M (2009) NHG-Standaard Beleid na een doorgemaakt myocardinfarct NHG-Standaarden voor de huisarts 2009, 10.1007/978-90-313-6614-9_5, (87-105), . Johansson M, Bernberg E, Andersson I, Bie P, Skøtt O, Gan L and Bergström G (2009) High-salt diet combined with elevated angiotensin II accelerates atherosclerosis in apolipoprotein E-deficient mice, Journal of Hypertension, 10.1097/HJH.0b013e328318697b, 27:1, (41-47), Online publication date: 1-Jan-2009. Ramos-Nino M and Blumen S (2009) Benefits of ACE Inhibitors in Diabetes, Clinical Medicine. Therapeutics, 10.4137/CMT.S2027, 1, (CMT.S2027), Online publication date: 1-Jan-2009. Wieneke H, Konorza T, Eggebrecht H, Naber C, Philipp S, Philipp T, Kribben A and Erbel R (2009) Die NierenarterienstenoseRenal Artery Stenosis. Pathophysiology – Diagnosis – Therapy, Medizinische Klinik, 10.1007/s00063-009-1073-z, 104:5, (349-355), Online publication date: 1-May-2009. Verma A and Solomon S (2009) Diastolic Dysfunction as a Link Between Hypertension and Heart Failure, Medical Clinics of North America, 10.1016/j.mcna.2009.02.013, 93:3, (647-664), Online publication date: 1-May-2009. Khazaei M, Sharifi A, Golbidi S and Laher I (2009) Reduction in Risk of Myocardial Infarction, Stroke, and Death from Cardiovascular Causes. Focus on Rampiril, Clinical Medicine. Therapeutics, 10.4137/CMT.S2095, 1, (CMT.S2095), Online publication date: 1-Jan-2009. Sekuri C, Utuk O, Bayturan O, Bilge A, Kurhan Z and Tavli T (2008) Effect of losartan on exercise tolerance and echocardiographic parameters in patients with mitral regurgitation, Journal of the Renin-Angiotensin-Aldosterone System, 10.3317/jraas.2008.016, 9:2, (107-111), Online publication date: 1-Jun-2008. Juhlin T, Jönsson B and Höglund P (2014) Renal effects of aspirin are clearly dose-dependent and are of clinical importance from a dose of 160 mg, European Journal of Heart Failure, 10.1016/j.ejheart.2008.06.014, 10:9, (892-898), Online publication date: 1-Sep-2008. Kim J, Brown S, Jenrow K and Ryu S (2008) Mechanisms of radiation-induced brain toxicity and implications for future clinical trials, Journal of Neuro-Oncology, 10.1007/s11060-008-9520-x, 87:3, (279-286), Online publication date: 1-May-2008. Yusuf S, Diener H, Sacco R, Cotton D, Ôunpuu S, Lawton W, Palesch Y, Martin R, Albers G, Bath P, Bornstein N, Chan B, Chen S, Cunha L, Dahlöf B, De Keyser J, Donnan G, Estol C, Gorelick P, Gu V, Hermansson K, Hilbrich L, Kaste M, Lu C, Machnig T, Pais P, Roberts R, Skvortsova V, Teal P, Toni D, VanderMaelen C, Voigt T, Weber M and Yoon B (2008) Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events, New England Journal of Medicine, 10.1056/NEJMoa0804593, 359:12, (1225-1237), Online publication date: 18-Sep-2008. Mistry N and Westheim A (2008) Antihypertensive treatment in patients with heart failure Manual of Hypertension of The European Society of Hypertension, 10.3109/9780203091722-56, (345-359), Online publication date: 11-Sep-2008. Billet S, Aguilar F, Baudry C and Clauser E (2008) Role of angiotensin II AT1 receptor activation in cardiovascular diseases, Kidney International, 10.1038/ki.2008.358, 74:11, (1379-1384), Online publication date: 1-Dec-2008. Kim J, Yun I, Choi Y, Lee K and Kim Y (2008) Ramipril protects from free radical induced white matter damage in chronic hypoperfusion in the rat, Journal of Clinical Neuroscience, 10.1016/j.jocn.2006.12.003, 15:2, (174-178), Online publication date: 1-Feb-2008. Fang W, Oreopoulos D and Bargman J (2008) Use of ACE inhibitors or angiotensin receptor blockers and survival in patients on peritoneal dialysis, Nephrology Dialysis Transplantation, 10.1093/ndt/gfn321, 23:11, (3704-3710), Online publication date: 1-Nov-2008. Rapp J and Gheorghiade M (2008) Role of Neurohormonal Modulators in Heart Failure with Relatively Preserved Systolic Function, Cardiology Clinics, 10.1016/j.ccl.2007.11.001, 26:1, (23-40), Online publication date: 1-Feb-2008. Ramos-Nino M, MacLean C and Littenberg B (2008) Association of angiotensin-converting enzyme inhibitor therapy and comorbidity in diabetes: results from the Vermont diabetes information system, BMC Endocrine Disorders, 10.1186/1472-6823-8-17, 8:1, Online publication date: 1-Dec-2008. Dubel G and Murphy T (2008) The role of percutaneous revascularization for renal artery stenosis, Vascular Medicine, 10.1177/1358863x07085408, 13:2, (141-156), Online publication date: 1-May-2008. Starchina Y, Parfenov V, Chazova I, Sinitsyn V, Pustovitova T, Kolos I and Ustyuzhanin D (2007) Cognitive function and the emotional state of stroke patients on antihypertensive therapy, Neuroscience and Behavioral Physiology, 10.1007/s11055-007-0143-z, 37:1, (13-17), Online publication date: 1-Jan-2007. Nesbitt S (2007) Antihypertensive Combination Therapy: Optimizing Blood Pressure Control and Cardiovascular Risk Reduction, The Journal of Clinical Hypertension, 10.1111/j.1524-6175.2007.07724.x, 9, (26-32) Asselbergs F and van Gilst W (2007) Angiotensin converting enzyme inhibition in cardiovascular risk populations: a practical approach to identify the patient who will benefit most, Current Opinion in Cardiology, 10.1097/HCO.0b013e3281a7ec81, 22:4, (267-272), Online publication date: 1-Jul-2007. Scaglione R, Argano C, Chiara T, Parrinello G, Colomba D, Avellone G, Donatelli M, Corrao S and Licata G (2007) Effect of dual blockade of renin–angiotensin system on TGFβ1 and left ventricular structure and function in hypertensive patients, Journal of Human Hypertension, 10.1038/sj.jhh.1002161, 21:4, (307-315), Online publication date: 1-Apr-2007. Gradman A and Traub D (2007) Angiotensin-Converting Enzyme Inhibitors Comprehensive Hypertension, 10.1016/B978-0-323-03961-1.50083-0, (985-1001), . Rahman S, Ismail A, Ismail S, Naing N and Abdul Rahman A (2007) Effect of rosiglitazone/ramipril on preclinical vasculopathy in newly diagnosed, untreated diabetes and IGT patients: 1-year randomised, double-blind, placebo-controlled study, European Journal of Clinical Pharmacology, 10.1007/s00228-007-0315-3, 63:8, (733-741), Online publication date: 1-Aug-2007. Kasi V, Xiao H, Shang L, Iravanian S, Langberg J, Witham E, Jiao Z, Gallego C, Bernstein K and Dudley S (2007) Cardiac-restricted angiotensin-converting enzyme overexpression causes conduction defects and connexin dysregulation, American Journal of Physiology-Heart and Circulatory Physiology, 10.1152/ajpheart.00684.2006, 293:1, (H182-H192), Online publication date: 1-Jul-2007. Campbell D (2