A Role for the Mouse 12/15-Lipoxygenase Pathway in Promoting Epithelial Wound Healing and Host Defense

Name: Work Video:
Duration: 3 min 30 s
Karsten Gronert; Neha Maheshwari; Nabeela Khan; Iram Hassan; Michael W. Dunn; Michal L. Schwartzman
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4056, 4133, 4167, 4199, 4214, 4232], 'the': [3, 39, 111, 124, 131, 154, 161, 175, 215, 240, 276, 348, 361, 368, 391, 398, 412, 452, 552, 831, 858, 994, 1010, 1108, 1387, 1395, 1531, 1696, 1779, 2026, 2289, 2309, 2326, 2336, 2344, 2379, 2414, 2427, 2430, 2518, 2521, 2534, 2547, 2580, 2610, 2638, 2672, 2689, 2703, 2707, 2711, 2739, 2758, 2831, 2926, 3038, 3049, 3064, 3088, 3231, 3328, 3521, 3550, 3563, 3933, 4047, 4054, 4282], 'eye': [4, 241, 2581, 2725], 'actively': [5, 242, 1015], 'suppresses': [6, 243], 'inflammation': [7, 244, 873, 979, 1102, 1118, 1402, 1539, 2974], 'while': [8, 30, 177, 245, 267, 414], 'maintaining': [9, 246, 1705], 'a': [10, 147, 188, 200, 211, 247, 384, 425, 437, 448, 489, 537, 557, 710, 984, 1303, 1390, 1920, 1928, 2283, 2360, 2375, 2400, 2447, 2453, 2473, 2480, 2572, 2604, 2613, 2617, 2625, 2631, 2661, 2682, 2699, 2823, 2827, 2837, 3044, 3098, 3242, 3287, 3515, 3571, 3735, 3739, 3742, 3745, 3750, 3762, 3777, 3816, 3897, 3902, 3919, 4011, 4057, 4183, 4196, 4229], 'remarkable': [11, 248, 711], 'capacity': [12, 249, 715], 'for': [13, 214, 250, 451, 481, 716, 1116, 1904, 1919, 2285, 2374, 2432, 2549, 2656, 2750, 2767, 2966, 3247, 3536, 3810, 3854, 3862, 3986, 4075, 4116, 4244], 'epithelial': [14, 90, 251, 327, 717, 2045, 2209, 2258, 2339, 2366, 2704], 'wound': [15, 95, 226, 252, 332, 463, 1105, 1136, 2367, 2384, 3055, 3066], 'repair.': [16, 253], 'Our': [17, 254], 'understanding': [18, 255], 'mechanisms': [20, 257, 1081], 'that': [21, 58, 67, 197, 228, 258, 295, 304, 434, 465, 869, 998, 1082, 1099, 1282, 1535, 1765, 1819, 1914, 1924, 2142, 2301, 2363, 2388, 2459, 2486, 2634, 2834, 3259, 3796, 3955], 'balance': [22, 259], 'inflammatory/reparative': [23, 260], 'responses': [24, 261, 1300, 1629, 2307], 'to': [25, 262, 492, 543, 572, 739, 977, 1014, 1089, 1296, 1927, 2124, 2298, 2317, 2334, 2426, 2553, 2556, 2579, 2582, 2588, 2591, 2637, 2671, 2757, 3048, 3053, 3252, 3290, 3326, 3366, 3544, 3820, 3957, 3968, 4014, 4069, 4139, 4193, 4226, 4281], 'provide': [26, 263, 1917, 2372], 'effective': [27, 264], 'host': [28, 265, 1298], 'defense': [29, 266], 'preserving': [31, 268], 'tissue': [32, 269, 545, 833, 1543], 'function': [33, 270, 567, 1480], 'is': [34, 229, 271, 466, 479, 541, 548, 556, 568, 857, 997, 1000, 1119, 1693, 1807, 1911, 2140, 2479, 2835], 'limited,': [35, 272], 'in': [36, 38, 174, 190, 203, 225, 273, 275, 411, 427, 440, 462, 551, 570, 938, 1107, 1386, 1413, 1416, 1704, 1805, 1810, 2036, 2119, 2134, 2206, 2255, 2288, 2308, 2325, 2351, 2383, 2434, 2520, 2533, 2624, 2743, 2830, 2836, 3018, 3082, 3202, 3230, 3266, 3280, 3756, 3869, 3981, 4001, 4023, 4029, 4042, 4046, 4053, 4178, 4186, 4202, 4219, 4235, 4301], 'particular,': [37, 274, 1806], 'cornea.': [40, 277, 1109, 2310], 'Lipoxin': [41, 278, 1407], 'A4': [42, 279, 1408], '(LXA4)': [43, 280], 'and': [44, 61, 73, 77, 92, 122, 135, 169, 194, 219, 223, 281, 298, 310, 314, 329, 359, 372, 406, 431, 456, 460, 483, 503, 563, 712, 862, 866, 874, 1134, 1163, 1171, 1289, 1306, 1373, 1403, 1451, 1540, 1624, 1720, 1774, 1783, 1813, 1816, 1823, 1838, 2040, 2199, 2247, 2349, 2353, 2356, 2386, 2392, 2422, 2436, 2496, 2511, 2514, 2536, 2542, 2566, 2571, 2627, 2644, 2654, 2658, 2706, 2775, 2777, 2799, 2922, 2931, 2953, 2969, 3035, 3057, 3063, 3084, 3218, 3227, 3277, 3302, 3311, 3518, 3525, 3540, 3553, 3570, 3579, 3592, 3749, 3759, 3813, 3838, 3841, 3857, 3918, 3932, 3945, 3966, 3972, 3976, 4019, 4077, 4085, 4121, 4123, 4137, 4174, 4206, 4238, 4273, 4297], 'docosahexaenoic': [45, 282, 756, 1775], 'acid-derived': [46, 283], 'neuroprotectin': [47, 284, 759, 2018], 'D1': [48, 285, 760, 2019], '(NPD1)': [49, 286], 'are': [50, 287, 1096, 1157, 1377, 1383, 1398, 2323, 2822, 2843], 'lipid': [51, 288, 865, 1154, 2299, 2321, 2741, 4215], 'autacoids': [52, 289, 1399, 2300, 2322, 2742], 'formed': [53, 290, 2324], 'by': [54, 89, 101, 181, 291, 326, 338, 418, 1121, 1301, 1424, 1612, 1695, 2249, 2413, 2602, 2650, 2660, 2716, 2781, 2794, 2947, 2975, 3092, 3213, 3225, 3235, 3307, 3313, 3815, 3843, 3940, 4172, 4182, 4241, 4321], '12/15-lipoxygenase': [55, 292], '(LOX)': [56, 293], 'pathways': [57, 100, 294, 337, 1156, 1295, 1376, 2295], 'exhibit': [59, 296], 'anti-inflammatory': [60, 235, 297, 472, 1114, 1172, 1411, 1822, 2027, 2320], 'neuroprotective': [62, 299, 2034], 'properties.': [63, 236, 300, 473, 2407], 'Here,': [64, 301, 2341], 'we': [65, 302, 2314, 2342, 2371], 'demonstrate': [66, 303, 1622, 2387], 'mouse': [68, 216, 305, 453, 2120, 2256, 2380, 3329, 3368], 'corneas': [69, 306, 2355, 2954, 3086, 3993, 4041, 4078, 4289, 4291], 'generate': [70, 307, 3969], 'endogenous': [71, 204, 308, 441, 1080, 1532, 2113, 2332, 2345, 3990], 'LXA4': [72, 78, 85, 105, 168, 205, 222, 309, 315, 322, 342, 405, 442, 459, 799, 1308, 1522, 1616, 2348, 2361, 2391, 2770, 2784, 4245], 'NPD1.': [74, 311], '12/15-LOX': [75, 217, 312, 454, 1375, 2150, 2252, 2381, 2806, 2928, 3372], '(Alox15)': [76, 218, 313, 455, 2253, 3373], 'receptor': [79, 316, 1617, 3331], 'mRNA': [80, 317, 2357, 3322], 'expression': [81, 318, 2193, 2254, 2358], 'as': [82, 84, 156, 158, 319, 321, 393, 395, 1286, 1474, 1476, 1526, 2328, 2472, 2698, 2943, 2945, 2971, 2979, 3097, 3241, 3333, 3514, 3534, 3599, 3868, 4071, 4087], 'well': [83, 157, 233, 320, 394, 470, 1475, 1697, 2844], 'formation': [86, 159, 180, 323, 396, 417, 863, 1309, 1388, 2115, 2346, 4213], 'were': [87, 324, 2411, 2423, 2443, 2544, 2560, 2600, 2648, 2694, 2721, 2753, 2762, 2779, 2812, 2941, 2951, 2955, 3031, 3041, 3061, 3080, 3200, 3255, 3260, 3270, 3278, 3317, 3364, 3532, 3582, 3754, 3830, 3852, 3860, 3964, 3979, 3999, 4044, 4079, 4111, 4125, 4128, 4148, 4162, 4176, 4191, 4224, 4295], 'abrogated': [88, 325], 'removal': [91, 145, 328, 382], 'restored': [93, 330], 'during': [94, 331, 1401], 'healing.': [96, 333, 2368], 'Amplification': [97, 334], 'these': [99, 208, 336, 445, 973, 1294, 1905, 2286, 2294], 'topical': [102, 339], 'treatment': [103, 166, 340, 403, 2389, 2752], 'with': [104, 167, 199, 341, 404, 436, 1615, 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'reduction': [202, 439, 3240], 'formation.': [206, 443], 'Collectively,': [207, 444], 'results': [209, 446, 2623], 'identify': [210, 447], 'novel': [212, 449, 2376], 'action': [213, 450], 'its': [220, 457, 566], 'products,': [221, 458], 'NPD1,': [224, 461, 758], 'healing': [227, 464, 1106, 1137, 2385], 'distinct': [230, 467, 1391, 2402], 'from': [231, 468, 1009, 1688, 2047, 2403, 2773, 2814, 3262, 3272, 3994], 'their': [232, 469, 2404], 'established': [234, 471, 1698, 3256, 3361, 3853, 3958], 'Activation': [474], 'an': [476, 1527, 2331, 2678, 3722, 3916, 4072], 'inflammatory/immune': [477], 'response': [478, 540, 1087], 'paramount': [480], 'mucosal': [482], 'dermal': [484], 'tissues,': [485], 'since': [486, 554, 1165, 1381], 'they': [487, 1166, 1382], 'form': [488], 'critical': [490, 569], 'barrier': [491], 'pathogens': [493, 1284], '(1Kumar': [494], 'V.': [495, 911, 3413], 'Fausto': [496], 'N.': [497, 522, 1457, 1748, 1787, 1948, 2068, 3407], 'Abbas': [498], 'A.': [499, 1229, 1250, 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3885], 'Med.': [525, 914, 1318, 1339, 1489, 1510, 1650, 1791, 3188, 3350, 3688, 3707, 3887], '1999;': [526, 844, 1251, 1729, 1753, 2239, 2894, 4101], '341:': [527], '738-746Crossref': [528], 'PubMed': [529, 587, 604, 621, 655, 676, 689, 702, 732, 888, 905, 918, 964, 1027, 1048, 1061, 1074, 1186, 1197, 1221, 1254, 1273, 1322, 1343, 1366, 1446, 1469, 1493, 1514, 1557, 1581, 1601, 1654, 1678, 1737, 1756, 1796, 1860, 1893, 1964, 1987, 2013, 2084, 2107, 2169, 2186, 2227, 2242, 2273, 2872, 2897, 2917, 3117, 3141, 3167, 3192, 3354, 3393, 3462, 3495, 3617, 3641, 3667, 3692, 3711, 3891, 4264], 'Scopus': [530, 588, 622, 656, 677, 690, 703, 733, 906, 919, 965, 1028, 1049, 1062, 1075, 1187, 1198, 1222, 1255, 1274, 1323, 1344, 1367, 1447, 1470, 1494, 1515, 1558, 1582, 1602, 1655, 1679, 1738, 1757, 1797, 1861, 1965, 1988, 2014, 2085, 2108, 2187, 2228, 2243, 2274, 2873, 2898, 2918, 3118, 3142, 3168, 3193, 3355, 3463, 3496, 3618, 3642, 3668, 3693, 3712, 3892, 4265], '(4740)': [531], 'Google': [532, 590, 605, 624, 645, 658, 679, 692, 705, 735, 847, 889, 908, 921, 967, 1030, 1051, 1064, 1077, 1189, 1200, 1224, 1257, 1276, 1325, 1346, 1369, 1449, 1472, 1496, 1517, 1560, 1584, 1604, 1657, 1681, 1740, 1759, 1799, 1863, 1877, 1894, 1967, 1990, 2016, 2087, 2110, 2170, 2189, 2230, 2245, 2276, 2875, 2900, 2920, 3001, 3120, 3144, 3170, 3195, 3357, 3394, 3431, 3465, 3498, 3620, 3644, 3670, 3695, 3714, 3894, 4104, 4267], 'Scholar).': [533, 706, 848, 968, 1078, 1151, 1277, 1370, 1518, 1605, 1682, 1760, 1800, 1895, 2111, 2190, 2277, 3026, 3196, 3358, 3715, 4105], 'However,': [534, 969, 1079, 1896, 2278], 'execution': [535], 'self-resolving': [538], 'inflammatory-reparative': [539], 'essential': [542, 1689], 'maintain': [544], 'function.': [546], 'This': [547, 1606, 2621], 'especially': [549], 'relevant': [550], 'cornea,': [553], 'it': [555, 737, 999, 1820, 2122], 'frequent': [558], 'site': [559], 'infection,': [561], 'injury,': [562, 2629], 'surgery;': [564], 'restoring': [565], 'order': [571], 'preserve': [573], 'vision': [574], '(3Lawrence': [575, 1174, 1545], 'T.': [576, 1175, 1235, 1546, 2853, 2878, 3337], 'Willoughby': [577, 1176, 1547], 'D.A.': [578, 1177, 1548], 'Gilroy': [579, 1178, 1549], 'D.W.': [580, 1179, 1550], 'Nat.': [581, 1180, 1551, 1596, 1649, 3112, 3612], 'Rev.': [582, 1181, 1552], 'Immunol.': [583, 1182, 1465, 1553, 1597, 3113, 3613], '2002;': [584, 1183, 1319, 1490, 1554, 1651, 2914, 3189, 3459, 3689, 3888], '2:': [585, 1184, 1555, 1599, 3115, 3615], '787-795Crossref': [586, 1185, 1556], '(710)': [589, 1188, 1559], '4Bazan': [592], 'N.G.': [593, 614, 877, 898, 1952, 1976, 2072, 2096, 2159, 3381], 'Allan': [594, 878], 'G.': [595, 879, 1666, 2865, 3129, 3183, 3629, 3683, 3882], 'Survey': [596, 880], 'Ophthalmol.': [597, 639, 841, 881, 1871, 2995], '1997;': [598, 642, 882, 2224, 2998, 3351], '41:': [599, 883], '23-34Abstract': [600, 884], 'Full': [601, 885, 959, 961, 1216, 1218, 1441, 1443, 1576, 1578, 1732, 1734, 1959, 1961, 2008, 2010, 2079, 2081, 2166, 3162, 3164, 3390, 3490, 3492, 3662, 3664], 'Text': [602, 886, 960, 962, 1217, 1219, 1442, 1444, 1577, 1579, 1733, 1735, 1960, 1962, 2009, 2011, 2080, 2082, 2167, 3163, 3165, 3391, 3491, 3493, 3663, 3665], 'PDF': [603, 887, 963, 1220, 1445, 1580, 1736, 1963, 2012, 2083, 2168, 3166, 3392, 3494, 3666], '5Bazan': [607, 891], 'H.E.': [608, 892, 952, 2157], 'Birkle': [609, 893], 'D.L.': [610, 894], 'Beuerman': [611, 895], 'R.W.': [612, 896], 'Bazan': [613, 897, 951, 1951, 1975, 2071, 2095, 2156, 2158], 'Curr.': [615, 899], 'Eye': [616, 900], 'Res.': [617, 901, 3427, 3458], '1985;': [618, 902], '4:': [619, 903], '175-179Crossref': [620, 904], '(67)': [623, 907], '6Conners': [626], 'M.S.': [627, 2216, 2983], 'Urbano': [628, 2984], 'F.': [629, 2797, 2985], 'Vafeas': [630, 2986], 'C.': [631, 1209, 1313, 1336, 1434, 1484, 1507, 1569, 2987], 'Stoltz': [632, 2988], 'Dunn': [634, 2990], 'M.W.': [635, 2991], 'Schwartzman': [636, 2992], 'M.L.': [637, 924, 2993, 3004], 'Investig.': [638, 728, 840, 2893, 2994], 'Visual': [640, 842, 1872, 2996], 'Sci.': [641, 843, 1212, 1247, 1361, 1437, 1572, 1873, 1980, 2100, 2220, 2997], '38:': [643, 2999], '1963-1971PubMed': [644, 3000], '7Streilein': [647], 'J.W.': [648, 1020], 'Leukocyte': [650, 671, 684, 697, 1022, 1043, 1056, 1069], 'Biol.': [651, 672, 685, 698, 954, 1023, 1044, 1057, 1070, 1954, 2003, 2074, 2161, 3157, 3385, 3485, 3657, 4100], '2003;': [652, 673, 686, 699, 956, 1024, 1045, 1058, 1071, 1466, 1675, 1956, 2005, 2076, 3138, 3159, 3428, 3638, 3659], '74:': [653, 674, 687, 700, 1025, 1046, 1059, 1072], '179-185Crossref': [654, 1026], '(263)': [657, 1029], '8Hamrah': [660, 1032], 'P.': [661, 837, 1033, 1885], 'Huq': [662, 1034], 'S.O.': [663, 1035], 'Liu': [664, 1036], 'Y.': [665, 1037, 1239, 1853, 1855], 'Zhang': [666, 1038], 'Q.': [667, 1039], 'Dana': [668, 1040], 'M.R.': [669, 1041], '172-178Crossref': [675, 1047], '(256)': [678, 1050], '9Niederkorn': [681, 1053], 'J.Y.': [682, 1054], '167-171Crossref': [688, 1060], '(99)': [691, 1063], '10Ono': [694, 1066], 'S.J.': [695, 1067, 3399], '149-150Crossref': [701, 1073], '(5)': [704, 1076], 'shows': [709], 'highly': [713, 1808], 'regulated': [714], 'regeneration,': [718], 'unlike': [719], 'other': [720, 2135], 'tissues': [721, 2136, 3199], '(11Simpson': [722], 'D.M.': [723], 'Ross': [724], 'R.': [725, 1710, 1828, 1881, 2884], 'Clin.': [727, 1888, 2892], '1972;': [729], '51:': [730], '2009-2023Crossref': [731], '(314)': [734], 'Scholar);': [736], 'appears': [738], 'be': [740, 1090, 2125, 2132], 'dependent': [741], 'infiltration': [743], 'polymorphonuclear': [745, 753], 'leukocytes': [746, 861], '(PMN)': [747], '1The': [748], 'abbreviations': [749], 'used': [750, 2942, 3365, 3513], 'are:': [751], 'PMN,': [752], 'leukocyte(s);': [754], 'DHA,': [755], 'acid;': [757, 775], '(10,17S-diH-DHA);': [761], 'diHDHA,': [762], 'dihydroxy-DHA;': [763], 'LXA4,': [764], 'lipoxin': [765, 3330], 'A4;': [766], 'LTB4,': [767], 'leukotriene': [768], 'B4;': [769], 'PGE2,': [770, 4272], 'prostaglandin': [771], 'E2;': [772], '12R-HETrE,': [773], '12R-hydroxy-eicosatrienoic': [774], 'GC,': [776], 'gas': [777, 3594], 'chromatography;': [778, 793, 823], 'MS,': [779], 'mass': [780], 'spectrometry;': [781], 'DAD,': [782], 'diode': [783, 3736], 'array': [784, 3737], 'detector;': [785], 'RP,': [786], 'reverse': [787, 811, 3556, 3585], 'phase;': [788], 'HPLC,': [789], 'high': [790, 3587], 'performance': [791, 3588], 'liquid': [792, 822, 3589], 'MPO,': [794], 'myeloperoxidase;': [795], 'LOX,': [796], 'lipoxygenase;': [797], 'ALX,': [798], 'receptor;': [800], 'HBSS,': [801], "Hanks'": [802], 'balanced': [803], 'salt': [804], 'solution;': [805], 'ATLa,': [806], '15-epi-16-(para-fluorophenoxylipoxin': [807, 2788], 'A4-methyl': [808, 2789], 'ester;': [809], 'RT,': [810], 'transcription;': [812], 'ELISA,': [813], 'enzyme-linked': [814], 'immunosorbent': [815], 'assay;': [816], 'ANOVA,': [817], 'analysis': [818, 2248, 2659, 3559, 3598, 3718, 3865], 'variance;': [820], 'LC,': [821], 'IL,': [824], 'interleukin;': [825], 'S,': [826], 'sinister;': [827], 'R,': [828], 'rectus.': [829], 'wounded': [832], '(12Gan': [834], 'L.': [835, 2175, 2909], 'Fagerholm': [836], 'Kim': [838, 1637], 'H.J.': [839], '40:': [845], '575-581PubMed': [846], 'A': [849, 990], 'cardinal': [850], 'sign': [851], 'injury': [854, 1544, 2647, 2732, 2965], 'infection': [856], 'protein': [867], 'mediators': [868, 1686], 'initiate': [870], 'and/or': [871, 2961], 'amplify': [872, 3327, 3367], 'neovascularization': [875, 2970], '(4Bazan': [876], '13Weimar': [910], 'Exp.': [913, 1317, 1338, 1488, 1509, 3187, 3349, 3687, 3706, 3886], '1957;': [915], '105:': [916], '141-152Crossref': [917], '(21)': [920], '14Schwartzman': [923, 3003], 'Green': [925, 1788, 3005], 'K.': [926, 1353, 1593, 1640, 1670, 1847, 1940, 1995, 2060, 2262, 3006, 3109, 3133, 3149, 3177, 3609, 3633, 3649, 3677, 3698, 3876, 4091], 'Edelhauser': [927, 3007], 'H.F.': [928, 3008], 'Hackett': [929, 3009], 'R.B.': [930, 3010], 'Hull': [931, 3011], 'D.S.': [932, 3012, 3415, 3477], 'Potter': [933, 3013], 'D.E.': [934, 3014], 'Tripathi': [935, 3015], 'R.C.': [936, 3016], 'Advances': [937, 3017], 'Occular': [939, 3019], 'Toxicology.': [940, 3020], 'Plenum': [941, 3021], 'Press,': [942, 3022], 'New': [943, 2415, 3023], 'York1997:': [944, 3024], '3-20Google': [945, 3025], '15Sharma': [947], 'G.D.': [948], 'He': [949], 'Chem.': [955, 1955, 2004, 2075, 2162, 3158, 3386, 3486, 3658], '278:': [957, 1957, 2006, 2077, 3160, 3660], '21989-21997Abstract': [958], '(297)': [966], 'aberrant': [970, 1422], 'activation': [971, 1018, 1129, 1453], 'circuits': [974], 'can': [975, 1167, 1292, 2131], 'lead': [976], 'sight-destroying': [978], 'and,': [980, 1415], 'thus,': [981], 'has': [982, 1523, 1608, 2116, 2203], 'been': [983, 1524, 1609, 2117, 2204], 'main': [985], 'focus': [986], 'research': [988], 'efforts.': [989], 'striking': [991], 'feature': [992], 'avascular': [995], 'largely': [1001], 'devoid': [1002], 'immunogenic-inflammatory': [1004], 'responses.': [1005], 'Moreover,': [1006], 'soluble': [1007], 'factors': [1008], 'aqueous': [1011], 'humor': [1012], 'appear': [1013], 'suppress': [1016, 1297], 'leukocyte': [1017], '(7Streilein': [1019], 'mediate': [1083], 'this': [1084, 1520, 2128, 2312], 'atypical': [1085], 'inflammatory': [1086, 1628, 1782, 2304], 'remain': [1088], 'clearly': [1091], 'delineated.': [1092], 'No': [1093], 'clinical': [1094], 'therapies': [1095], 'currently': [1097], 'available': [1098], 'selectively': [1100], 'target': [1101], 'promote': [1104, 1536], 'use': [1112], 'glucocorticoids': [1115], 'restricted': [1120, 2636], 'serious': [1122], 'side': [1123], 'effects,': [1124], 'including': [1125], 'cataract': [1126], 'formation,': [1127, 4288], 'glaucoma,': [1128], 'latent': [1131], 'herpes': [1132], 'simplex,': [1133], 'delayed': [1135], '(16Fraunfelder': [1138], 'F.T.': [1139], 'Fraunfelder': [1140], 'F.W.': [1141], 'Drug-induced': [1142], 'Ocular': [1143], 'Side': [1144], 'Effects,': [1145], '5th': [1146], 'Butterworth-Heinemann,': [1148], 'Boston,': [1149], 'MA2001Google': [1150], 'Lipoxygenase': [1152], '(LOX)-initiated': [1153], 'mediator': [1155, 1930, 2130], 'important': [1158, 1528], 'regulators': [1159], 'innate': [1161], 'immunity': [1162], 'inflammation,': [1164, 1423], 'activate': [1168], 'pro-': [1170], 'signals': [1173, 1534], '17Funk': [1191], 'C.D.': [1192, 2890, 2903, 3383, 3421, 3452, 3475], 'Science.': [1193, 1269, 2868], '2001;': [1194, 1213, 1438, 1573, 1598, 3114, 3614], '294:': [1195], '1871-1875Crossref': [1196], '(3070)': [1199], '18McMahon': [1202, 1562], 'B.': [1203, 1260, 1428, 1563, 1591, 3107, 3607], 'Mitchell': [1204, 1429, 1564], 'S.': [1205, 1233, 1249, 1332, 1351, 1430, 1503, 1565, 1664, 1712, 1830, 1934, 1982, 1993, 2054, 2102, 2222, 2886, 3127, 3147, 3175, 3339, 3403, 3627, 3647, 3675, 3874, 4249], 'Brady': [1206, 1431, 1566, 3342], 'H.R.': [1207, 1432, 1567, 3343], 'Godson': [1208, 1433, 1568], 'Trends': [1210, 1435, 1570], 'Pharmacol.': [1211, 1436, 1571], '22:': [1214, 1439, 1574], '391-395Abstract': [1215, 1440, 1575], '(123)': [1223, 1448, 1583], '19Munger': [1226], 'K.A.': [1227], 'Montero': [1228], 'Fukunaga': [1230], 'M.': [1231, 1459, 1662, 1849, 1944, 2064, 2155, 2173, 2233, 2268, 2859, 3125, 3409, 3440, 3625, 4095], 'Uda': [1232], 'Yura': [1234], 'Imai': [1236], 'E.': [1237, 1638, 2235, 4253], 'Kaneda': [1238], 'Valdivielso': [1240], 'J.M.': [1241, 1646, 1946, 2066, 4257], 'Badr': [1242], 'K.F.': [1243], 'Proc.': [1244, 1358, 1977, 2097, 2217], 'Natl.': [1245, 1359, 1978, 2098, 2218], 'Acad.': [1246, 1360, 1979, 2099, 2219], 'U.': [1248, 1981, 2101, 2221, 3377], '96:': [1252], '13375-13380Crossref': [1253], '(136)': [1256], '20Samuelsson': [1259], 'Dahlén': [1261], 'S.E.': [1262, 3401], 'Lindgren': [1263], 'J.Å.': [1264], 'Rouzer': [1265], 'C.A.': [1266], 'Serhan': [1267, 1312, 1335, 1354, 1462, 1483, 1506, 1594, 1647, 1671, 1949, 1973, 2000, 2069, 2093, 3110, 3134, 3154, 3346, 3610, 3634, 3654, 3703, 4096, 4258], 'C.N.': [1268, 1355, 1463, 1595, 1648, 1672, 1950, 1974, 2001, 2070, 2094, 3111, 3135, 3155, 3173, 3347, 3611, 3635, 3655, 3673, 3704, 3872, 4097, 4259], '1987;': [1270], '237:': [1271], '1171-1176Crossref': [1272], '(1987)': [1275], 'Recent': [1278], 'studies': [1279, 1614, 1762, 2280, 2410], 'have': [1280, 1763, 2281], 'demonstrated': [1281, 1764, 2118, 2205], 'human': [1283, 1372, 1706, 2042, 2207], 'such': [1285], 'Pseudomonas': [1287], 'aeruginosa': [1288], 'Toxoplasma': [1290], 'gondii': [1291], 'exploit': [1293], 'immune': [1299], 'expressing': [1302], 'functional': [1304], '15-LOX': [1305, 2195, 2832], 'inducing': [1307], '(21Aliberti': [1310, 1481], 'Sher': [1314, 1333, 1485, 1504], '196:': [1320, 1491, 3190, 3690, 3889], '1253-1262Crossref': [1321, 1492], '(176)': [1324, 1495], '22Bannenberg': [1327, 1498], 'G.L.': [1328, 1499], 'Aliberti': [1329, 1500], 'Hong': [1331, 1350, 1502, 1663, 1933, 2053, 3126, 3174, 3626, 3674, 3873], '2004;': [1340, 1363, 1511, 1984, 2104, 2869], '199:': [1341, 1512], '515-523Crossref': [1342, 1513], '(82)': [1345, 1516], '23Vance': [1348], 'R.E.': [1349], 'Gronert': [1352, 1592, 1669, 1939, 1994, 2059, 3108, 3132, 3148, 3176, 3608, 3632, 3648, 3676, 3875], 'Mekalanos': [1356], 'J.J.': [1357], 'U.S.A.': [1362], '101:': [1364, 1985, 2105], '2135-2139Crossref': [1365], '(157)': [1368], 'murine': [1374], 'particular': [1379], 'interest,': [1380], 'key': [1384], 'enzymes': [1385, 2287], 'class': [1392], 'lipoxins,': [1396], 'which': [1397, 1621, 2022], 'generated': [1400, 2133], 'heterotypic': [1404], 'cell-cell': [1405], 'interactions.': [1406], 'exhibits': [1409, 2033], 'potent': [1410], 'properties': [1412, 1907, 2035], 'vitro': [1414], 'animal': [1417, 2409], 'models': [1418, 2594], 'acute': [1420], 'inhibiting': [1425], 'PMN': [1426, 2398, 3079, 3100, 3253, 3258], '(18McMahon': [1427], 'Scholar)': [1450, 1473, 2921, 3432, 3466, 3499, 4268], 'lymphocyte': [1452], '(24Ariel': [1454], 'Chiang': [1456, 1947, 2067], 'Arita': [1458, 1661, 3124, 3624], 'Petasis': [1460, 3344], 'N.A.': [1461, 3345, 3379], '170:': [1467], '6266-6272Crossref': [1468], '(164)': [1471], 'suppressing': [1477], 'dendritic': [1478], 'cell': [1479], 'regard,': [1521], 'implicated': [1525], 'component': [1529], 'counterregulatory': [1533], 'resolution': [1537, 1626], 'limit': [1541, 2335], 'PMN-mediated': [1542], '25Levy': [1586], 'B.D.': [1587, 1631, 3103, 3603, 4247], 'Clish': [1588, 3104, 3604, 4092], 'C.B.': [1589, 3105, 3605, 4093], 'Schmidt': [1590, 1641, 1715, 1833, 3106, 3606], '612-619Crossref': [1600, 3116, 3616], '(1119)': [1603, 3119, 3619], 'conclusion': [1607], 'further': [1610], 'substantiated': [1611], 'recent': [1613], '(ALX)': [1618], 'transgenic': [1619], 'mice,': [1620], 'inhibition': [1623], 'accelerated': [1625], '(26Levy': [1630], 'De': [1632], 'Sanctis': [1633], 'G.T.': [1634], 'Devchand': [1635, 1996, 3150, 3180, 3650, 3680, 3879], 'P.R.': [1636, 1660, 1997, 3123, 3151, 3181, 3623, 3651, 3681, 3880], 'Ackerman': [1639], 'B.A.': [1642], 'Szczeklik': [1643], 'W.': [1644, 3446, 3456], 'Drazen': [1645, 4256], '8:': [1652], '1018-1023Crossref': [1653], '(337)': [1656], '27Devchand': [1659, 3122, 3622], 'Bannenberg': [1665, 3128, 3628], 'Moussignac': [1667, 1998, 3130, 3152, 3184, 3630, 3652, 3684, 3883], 'R.L.': [1668, 1999, 3131, 3153, 3185, 3405, 3631, 3653, 3685, 3884], 'FASEB': [1673, 3136, 3636], '17:': [1676, 3139, 3639], '652-659Crossref': [1677, 3140, 3640], '(158)': [1680, 3143, 3643], 'importance': [1684], 'derived': [1687], 'polyun-saturated': [1690], 'fatty': [1691, 1702], 'acid': [1692, 1776, 1802], 'underscored': [1694], 'role': [1699, 2284, 2377], 'ω-3': [1701, 2522], 'acids': [1703], 'health': [1707], '(28De': [1708, 1826], 'Caterina': [1709, 1827, 1880], 'Endres': [1711, 1829], 'Kristensen': [1713, 1831], 'S.D.': [1714, 1832], 'E.B.': [1716, 1834], 'n-3': [1717, 1835], 'Fatty': [1718, 1836], 'Acids': [1719, 1837], 'Vascular': [1721, 1839], 'Springer-Verlag,': [1723, 1841], 'London1993Google': [1724, 1842], '29Investigators': [1726], 'G-P.': [1727], 'Lancet.': [1728], '354:': [1730], '447-455Abstract': [1731], '(3761)': [1739], '30Simopoulos': [1742], 'A.P.': [1743], 'Leaf': [1744], 'Salem': [1746], 'Jr.,': [1747], 'Am.': [1750, 1886], 'Coll.': [1751], 'Nutr.': [1752, 1889], '18:': [1754], '487-489Crossref': [1755], '(230)': [1758], 'Epidemiological': [1761], 'consumption': [1766], 'fish': [1768, 2467, 2525], 'oil-enriched': [1769], 'diets': [1770], 'containing': [1771, 3208, 4036, 4304], 'eicosapentaenoic': [1772, 2509], '(EPA)': [1773], '(DHA)': [1777], 'lowers': [1778], 'incidence': [1780], 'autoimmune': [1784], 'diseases': [1785], '(31Kromann': [1786], 'Acta': [1790], 'Scand.': [1792], '1980;': [1793], '208:': [1794], '401-406Crossref': [1795], '(781)': [1798], 'Docosahexaenoic': [1801], '(DHA,': [1803], '22:6),': [1804], 'concentrated': [1809], 'photoreceptors,': [1811], 'brain,': [1812], 'retinal': [1814, 2043], 'synapses,': [1815], 'evidence': [1817, 1918, 2373], 'suggests': [1818, 2251], 'exerts': [1821], 'immunosuppressive': [1824], 'effects': [1825], '32Tomobe': [1844], 'Y.I.': [1845], 'Morizawa': [1846], 'Tsuchida': [1848], 'Hibino': [1850], 'H.': [1851, 2266, 3442], 'Nakano': [1852], 'Tanaka': [1854], 'Lipids.': [1856, 4260], '2000;': [1857, 1890], '35:': [1858], '61-69Crossref': [1859], '(59)': [1862], '33Verbey': [1865], 'N.L.': [1866], 'van': [1867], 'Haeringen': [1868], 'N.J.': [1869], 'Investigative': [1870], '1990;': [1874], '31:': [1875], '1526-1532PubMed': [1876], '34De': [1879], 'Liao': [1882], 'J.K.': [1883, 2863], 'Libby': [1884], '71:': [1891], '213S-223SCrossref': [1892], 'until': [1897], 'recently,': [1898], 'clear': [1900], 'mechanism': [1901], 'could': [1902], 'account': [1903], 'beneficial': [1906], 'DHA.': [1909], 'It': [1910, 2139], 'interest': [1913], 'several': [1915, 2146], 'reports': [1916], '15-LOX-like': [1921], 'initiated': [1922], 'pathway': [1923, 2362, 2382], 'gives': [1925], 'rise': [1926, 2297], 'DHA-derived': [1929], '(35Marcheselli': [1931, 2051], 'V.L.': [1932, 1972, 2052, 2092], 'Lukiw': [1935, 2055], 'W.J.': [1936, 2056], 'Tian': [1937, 2057], 'X.H.': [1938, 2058], 'Musto': [1941, 2061], 'Hardy': [1943, 2063], 'Gimenez': [1945, 2065], '43807-43817Abstract': [1958, 2078], '(686)': [1966, 2086], '36Mukherjee': [1969, 2089], 'P.K.': [1970, 2090], 'Marcheselli': [1971, 2091], '8491-8496Crossref': [1986, 2106], '(655)': [1989, 2109], '37Hong': [1992, 3146, 3646], '14677-14687Abstract': [2007, 3161, 3661], '(844)': [2015, 3169, 3669], 'Scholar),': [2017, 2246], '(NPD1;': [2020], '10,17S-docosatriene),': [2021], 'mimics': [2023], 'many': [2024], 'actions': [2028], 'LXA4.': [2030], 'Specifically,': [2031], 'NPD-1': [2032, 2114], 'experimental': [2037], 'ischemic': [2038], 'stroke': [2039], 'protects': [2041], 'pigment': [2044], 'cells': [2046, 2210, 2259], 'oxidative': [2048], 'stress-induced': [2049], 'apoptosis': [2050], 'Although': [2112], 'brains,': [2121], 'remains': [2123], 'determined': [2126, 2649], 'whether': [2127, 2293, 2319], 'protective': [2129], 'organs.': [2138], 'notable': [2141], 'epithelia': [2144], 'species': [2147], 'express': [2148, 2925], 'prominent': [2149], 'activity': [2151, 3095, 3229], '(38Hurst': [2152], 'J.S.': [2153], 'Balazy': [2154], '1991;': [2163], '266:': [2164], '6726-6730Abstract': [2165], '39Liminga': [2172], 'Hornsten': [2174], 'Sprecher': [2176], 'H.W.': [2177], 'Oliw': [2178, 2234, 3478], 'E.H.': [2179, 3479], 'Biochim.': [2180, 2236], 'Biophys.': [2181, 2237], 'Acta.': [2182, 2238], '1994;': [2183, 3387], '1210:': [2184], '288-296Crossref': [2185], '(28)': [2188], 'Furthermore,': [2191], 'RNA': [2192, 3295, 3303, 3542, 3551], 'type': [2196, 2200], '1': [2197], '(ALOX15)': [2198], '2': [2201, 2540, 3982], '(ALOX15B)': [2202], '(40Brash': [2211], 'A.R.': [2212, 3423, 3483], 'Boeglin': [2213, 3410, 3480], 'W.E.': [2214, 3411, 3481], 'Chang': [2215], '94:': [2225], '6148-6152Crossref': [2226], '(360)': [2229], '41Liminga': [2232], '1437:': [2240], '124-135Crossref': [2241], '(14)': [2244], 'immunohistochemistry': [2250], 'lens': [2257], '(42van': [2260], 'Leyen': [2261], 'Duvoisin': [2263], 'R.M.': [2264], 'Engelhardt': [2265], 'Wiedmann': [2267], 'Nature.': [2269], '1998;': [2270, 3708], '395:': [2271], '392-395Crossref': [2272], '(255)': [2275], 'identified': [2282], 'investigated': [2292], 'give': [2296], 'may': [2302], 'regulate': [2303], 'immunogenic': [2306], 'To': [2311, 4211, 4285], 'end,': [2313], 'set': [2315], 'out': [2316], 'determine': [2318], 'part': [2329], 'program': [2333], 'report': [2343], 'healthy': [2352, 3995], 'injured': [2354, 3997], 'correlates': [2364], 'addition,': [2370], 'accelerates': [2394], 'without': [2396, 3549, 3555, 4005, 4313], 'impairing': [2397], 'recruitment,': [2399], 'bioaction': [2401], 'documented': [2405, 2655], 'leukocyte-selective': [2406], 'All': [2408], 'approved': [2412], 'York': [2416], 'Medical': [2417], 'College': [2418], 'Vertebrate': [2419], 'Animal': [2420], 'Committee': [2421], 'performed': [2424, 3561, 3720, 3867], 'according': [2425, 4280], 'guidelines': [2428], 'Association': [2431], 'Research': [2433], 'Vision': [2435], 'Ophthalmology.': [2437], 'Male': [2438], 'BALB/c': [2439, 3267], '(6–8': [2441], 'weeks)': [2442], 'placed': [2444, 2545, 4022, 4112], 'either': [2445, 2463, 4020], 'standard': [2448, 2481, 4074], 'rodent': [2449, 2484], 'diet': [2450, 2455, 2478, 2485, 2527, 2548], 'custom': [2454], '(Research': [2456], 'Diets,': [2457], 'Inc.)': [2458], 'was': [2460, 2528, 2537, 2577, 2635, 2675, 2714, 2771, 2791, 3068, 3223, 3233, 3296, 3305, 3512, 3560, 3719, 3866, 3929, 3936, 4067, 4319], 'based': [2461, 3319], 'corn': [2464], 'oil': [2465, 2468, 2503, 2526], '(menhaden': [2469], 'oil,': [2470], 'ω-3)': [2471], 'fat': [2474, 2483, 2519], 'source.': [2475], 'AIN-76A': [2477], 'low': [2482], 'contains': [2487, 2504], '20.8': [2488], 'kcal': [2489, 2493, 2498], '%': [2490, 2494, 2499], 'protein,': [2491], '67.7': [2492], 'carbohydrates,': [2495], '11.5': [2497], 'fat.': [2500], 'menhaden': [2502], '2%': [2505], 'arachidonic': [2506], '14%': [2508], '11%': [2512], 'DHA': [2513, 3580], 'represents': [2515], '90%': [2516], 'diet.': [2523], 'kept': [2529], 'at': [2530, 2803, 3087, 3832, 4082, 4113, 4117, 4208], '4': [2531, 4083], '°C': [2532, 3942, 3947, 4084, 4115], 'dark': [2535, 4048], 'replaced': [2538], 'every': [2539, 2751], 'days,': [2541], 'animals': [2543, 2590], '3–4': [2550], 'weeks': [2551], 'prior': [2552, 2587, 2756], 'being': [2554], 'subjected': [2555], 'Mice': [2559, 2720, 2950], 'anesthetized': [2561, 3029], 'ketamine': [2563], '(50': [2564, 4065], 'mg/kg)': [2565, 2569], 'xylazine': [2567], '(20': [2568], 'intramuscularly,': [2570], 'drop': [2573], 'tetracaine-HCl': [2575], '0.5%': [2576, 3209], 'applied': [2578], 'deliver': [2583], 'local': [2584], 'anesthesia': [2586], 'subjecting': [2589], 'two': [2592, 3790], 'separate': [2593, 3791], 'injuries.': [2597], 'Thermal': [2598], 'Injury—Corneas': [2599], 'cauterized': [2601], 'drawing': [2603], 'vertical': [2605], 'line': [2606], '(∼1–2': [2607], 'mm)': [2608], 'across': [2609], 'heated': [2614, 3746], 'microprobe': [2615], 'under': [2616, 2688, 3286, 4010, 4195, 4228], 'slit': [2618, 2651, 2690, 2976, 3050], 'lamp': [2619, 2652, 2691, 2977, 3051], 'biomicroscope.': [2620, 2692], 'method': [2622], 'significant': [2626], 'consistent': [2628], 'namely': [2630], '1–2-mm': [2632], 'burn': [2633], 'anterior': [2639, 3039], 'surface.': [2641], 'Wound': [2642], 'size': [2643], 'degree': [2645], 'biomicroscopy': [2653], 'quantitation': [2657], 'CCD': [2662, 3045], 'camera': [2663, 3046], '(MicroPublisher,': [2664], 'QImaging).': [2665], 'Removal—The': [2667], 'epithelium': [2669], 'up': [2670], 'corneal/limbal': [2673], 'border': [2674], 'removed': [2676, 3224, 4320], 'using': [2677, 3070, 3237, 3274, 3298, 3520, 3789], 'Algerbrush': [2679], 'II': [2680], '0.5-mm': [2683], 'rust': [2685], 'ring': [2686], 'remover': [2687], 'Corneas': [2693, 3269], 'stained': [2695, 3032], 'fluorescein': [2697], 'direct': [2700], 'marker': [2701, 3101], 'defect,': [2705], 'total': [2708], 'area': [2709, 3067], 'denuded': [2712], 'quantitated': [2715, 3069, 3081, 3312], 'image': [2717, 3071], 'software': [2718, 3072, 3847], 'analyses.': [2719], 'treated': [2722], 'topically': [2723], 'drop;': [2726], '10': [2727, 4131, 4165], 'μl)': [2728], 'immediately': [2729, 2755, 4021, 4149, 4239], 'after': [2730, 2964], 'de-epithelialization': [2734], '0.01–1': [2736], 'μg': [2737], 'indicated': [2740, 3089], '100%': [2744, 4024], 'sterile': [2745, 3275, 3281], 'HBSS': [2746, 4003, 4030, 4302], '(pH': [2747, 3206, 4032], '7.4);': [2748], 'solutions': [2749], 'prepared': [2754, 2780], 'application.': [2759], 'treatments': [2761], 'repeated': [2763], 'three': [2764, 3214], 'times': [2765, 3960], 'daily': [2766], '24–96': [2768], 'h.': [2769], 'purchased': [2772, 2813], 'Calbiochem,': [2774], '17S-HDHA': [2776], 'biogenic': [2782], 'synthesis.': [2783], 'stable': [2785], 'analog': [2786], '(ATLa,': [2787], 'ester)': [2790], 'kindly': [2792], 'provided': [2793], 'Drs.': [2795], 'John': [2796], 'Parkinson': [2798], 'William': [2800], 'Guilford': [2802], 'Berlex': [2804], 'Bioscience.': [2805], '(Alox15)-deficient': [2807], '(6': [2809, 2938], 'weeks,': [2810, 2939], 'female)': [2811, 2940], 'Jackson': [2815, 2948], 'Laboratory': [2816], '(Bar': [2817], 'Harbor,': [2818], 'ME).': [2819], 'These': [2820], 'Jax®Gemm®': [2824], 'Strain': [2825], 'targeted': [2828], 'mutation': [2829], '(Alox15tm1Fun)': [2833], 'background': [2838], 'C57BL/6J': [2839, 2934], 'inbreed': [2840], 'strain.': [2841], 'They': [2842], 'characterized': [2845], '(43Klein': [2846], 'R.F.': [2847], 'Allard': [2848], 'Avnur': [2850], 'Z.': [2851, 3450], 'Nikolcheva': [2852], 'Rotstein': [2854], 'D.': [2855], 'Carlos': [2856], 'A.S.': [2857], 'Shea': [2858], 'Waters': [2860], 'R.V.': [2861], 'Belknap': [2862], 'Peltz': [2864], 'Orwoll': [2866], 'E.S.': [2867], '303:': [2870], '229-232Crossref': [2871], '(251)': [2874], '44Cyrus': [2877], 'Witztum': [2879], 'J.L.': [2880, 3702], 'Rader': [2881], 'D.J.': [2882], 'Tangirala': [2883], 'Fazio': [2885], 'Linton': [2887], 'M.F.': [2888, 3417], 'Funk': [2889, 3382, 3420, 3451], '103:': [2895], '1597-1604Crossref': [2896], '(466)': [2899], '45Funk': [2902], 'Chen': [2904], 'X.S.': [2905, 3375], 'Johnson': [2906], 'E.N.': [2907], 'Zhao': [2908], 'Prostaglandins': [2910], 'Other': [2911], 'Lipid': [2912], 'Mediators.': [2913], '68:': [2915], '303-312Crossref': [2916], '(150)': [2919], 'do': [2923], 'not': [2924], '“leukocyte-type”': [2927], '(Alox15).': [2929], 'Age-': [2930], 'gender-matched': [2932], 'congenic': [2933], 'stock': [2935], '000664': [2936], 'controls': [2944, 3535], 'suggested': [2946], 'Laboratory.': [2949], 'anesthetized,': [2952], 'subjectively': [2956], 'assessed': [2957], '24,': [2958], '48,': [2959], '72,': [2960], '96': [2962], 'h': [2963], 'cloudiness,': [2967], 'opacity,': [2968], 'markers': [2972], 'biomicroscopy,': [2978], 'previously': [2980, 3334, 3600, 4088], 'cited': [2981], '(6Conners': [2982], 'Eyes': [3027], 'fluorescein,': [3034], 'images': [3036, 3060], 'taken': [3042, 4192, 4225], 'attached': [3047], 'biomicroscope': [3052], 'quantitate': [3054, 4212, 4286], 'closure': [3056], 'Digital': [3059], 'analyzed,': [3062], 'fluorescein-stained': [3065], 'analyses': [3073], '(Adobe': [3074], 'Photoshop,': [3075], 'San': [3076], 'Jose,': [3077], 'CA).': [3078], 'dissected': [3083, 3271, 4000], 'cleaned': [3085, 3279, 4009], 'time': [3090], 'points': [3091], 'measuring': [3093], 'myeloperoxidase': [3094], '(MPO)': [3096], 'specific': [3099, 3546, 4242], '(25Levy': [3102, 3602], '46Serhan': [3172, 3672, 3871], 'Colgan': [3178, 3678, 3877], 'S.P.': [3179, 3679, 3878], 'Mirick': [3182, 3682, 3881], '1025-1037Crossref': [3191, 3691, 3890], '(1362)': [3194, 3694, 3893], 'brief,': [3198, 3717, 4107], 'homogenized': [3201, 4081, 4108, 4298], 'potassium': [3203], 'phosphate': [3204], 'buffer': [3205, 4004, 4031, 4043, 4303], '6.0)': [3207], 'hexadecyltrimethylammonium': [3210], 'bromide,': [3211], 'followed': [3212, 3814, 3939, 4171, 4181], 'cycles': [3215], 'sonication': [3217], 'freeze-thaw.': [3219], 'particulate': [3221], 'matter': [3222], 'centrifugation,': [3226], 'MPO': [3228, 3250], 'supernatant': [3232], 'measured': [3234], 'spectrophotometry': [3236], 'o-dianisidine': [3238], 'dihydrochloride': [3239], 'colorimetric': [3243], 'indicator.': [3244], 'Calibration': [3245, 3850], 'curves': [3246, 3851], 'conversion': [3248], 'activities': [3251], 'number': [3254], 'collected': [3261, 3965], 'zymosan': [3263], 'A-induced': [3264], 'peritonitis': [3265], 'mice.': [3268], 'eyes': [3273, 3998], 'instruments': [3276], 'phosphate-buffered': [3282], 'saline': [3283], '(4': [3284], '°C)': [3285, 4035], 'dissecting': [3288, 4012], 'microscope': [3289, 4013], 'remove': [3291, 4015], 'all': [3292, 4016], 'noncorneal': [3293, 4017], 'tissue.': [3294], 'isolated': [3297, 4296], 'TRIzol': [3299], 'reagent': [3300], '(Invitrogen),': [3301], 'integrity': [3304], 'verified': [3306], 'agarose': [3308], 'gel': [3309], 'electrophoresis': [3310], 'spectrophotometry.': [3314], 'Specific': [3315], 'primers': [3316], 'designed': [3318], 'published': [3321], 'sequences': [3323], '(PubMed,': [3324], 'GenBank™)': [3325], 'ALX': [3332], 'described': [3335, 3601], '(47Takano': [3336], 'Fiore': [3338], 'Maddox': [3340], 'J.F.': [3341], '185:': [3352], '1693-1704Crossref': [3353], '(390)': [3356], 'following': [3360], 'primer': [3362, 3523, 3527, 3538], 'pairs': [3363], 'lipoxygenases:': [3369], '1)': [3370, 3548], 'leukocyte-type': [3371], '(48Chen': [3374], 'Kurre': [3376], 'Jenkins': [3378], 'Copeland': [3380], '269:': [3388], '13979-13987Abstract': [3389], '49Shappell': [3396], 'S.B.': [3397], 'Olson': [3398], 'Hannah': [3400], 'Manning': [3402], 'Roberts': [3404], 'Masumori': [3406], 'Jisaka': [3408], 'Vader': [3412], 'Dave': [3414], 'Shook': [3416], 'Thomas': [3418], 'T.Z.': [3419], 'Brash': [3422, 3482], 'Matusik': [3424], 'R.J.': [3425], 'Cancer': [3426], '63:': [3429], '2256-2267PubMed': [3430], '(sense,': [3433, 3467, 3500, 3507], '5′-GCGACGCTGCCCAATCCTAATC-3′;': [3434], 'antisense,': [3435, 3469, 3502, 3509], '5′-CATATGGCCACGCTGTTTTCTACC-3′);': [3436], '5-LOX': [3437], '(Alox5)': [3438], '(50Mehrabian': [3439], 'Allayee': [3441], 'Wong': [3443], 'Shi': [3445], 'Wang': [3447], 'X.P.': [3448], 'Shaposhnik': [3449], 'Lusis': [3453], 'Shih': [3455], 'Circ.': [3457], '91:': [3460], '120-126Crossref': [3461], '(374)': [3464], '5′-ATGCCCTCCTACACTGTCAC-3′;': [3468], '5′-CCACTCCATCCATCTATACT-3′);': [3470], 'epidermal-type': [3471], '12-LOX': [3472, 3505], '(Aloxe)': [3473], '(51Funk': [3474], 'Keeney': [3476], '1996;': [3487], '271:': [3488], '23338-23344Abstract': [3489], '(85)': [3497], '5′-AGTGACACCGATGTGAAGGAG-3′;': [3501], '5′-CTCTCAGATGGTCACACTG-3′);': [3503], 'platelet-type': [3504], '(Alox12)': [3506], '5′-CGCGGGGCAAGGAGGAGGAGT-3′;': [3508], '5′-GGGGTTGGCGCCATTGAGGA-3′).': [3510], 'β-Actin': [3511], 'reference': [3516], 'gene': [3517], 'amplified': [3519], 'sense': [3522], '5′-ACGGCCAGGTCATCACTATTG-3′': [3524], 'antisense': [3526], '5′-AGGGGCCGGACTCATCGTA-3′.': [3528], 'Two': [3529], 'PCR': [3530], 'amplifications': [3531], 'carried': [3533], 'each': [3537, 3855], 'pair': [3539], 'sample': [3543], 'confirm': [3545], 'amplification:': [3547], 'template': [3552], '2)': [3554], 'transcription.': [3557], 'RT-PCR': [3558, 3565], 'OneStep': [3564], 'kit': [3566], '(Qiagen,': [3567], 'Valencia,': [3568], 'CA)': [3569, 3732, 3775], 'Gradient': [3572], 'cycler': [3574], '(PTC-200;': [3575], 'MJ': [3576], 'Research).': [3577], 'Eicosanoids': [3578], 'products': [3581], 'analyzed': [3583, 3842, 4240], 'employing': [3584], 'phase': [3586, 3758, 3794], 'chromatography': [3590], '(RP-HPLC)': [3591], 'capillary': [3593], 'chromatography/mass': [3595], 'spectrometry': [3596], '(GC/MS)': [3597], '52Gronert': [3697], 'Gewirtz': [3699], 'Madara': [3701], '187:': [3709], '1285-1294Crossref': [3710], '(194)': [3713], 'Agilent': [3723, 4159], '1100': [3724], 'series': [3725], 'HPLC': [3726, 3953, 4134, 4168], 'system': [3727, 3900], '(Agilent': [3728, 3848, 3923], 'Technologies,': [3729], 'Palo': [3730], 'Alto,': [3731], 'equipped': [3733], 'detector,': [3738], 'binary': [3740], 'pump,': [3741], 'membrane': [3743], 'degasser,': [3744], 'column': [3747, 3766, 3781, 3907], 'compartment,': [3748], 'microflow': [3751], 'cell.': [3752], 'Samples': [3753], 'injected': [3755, 3980], 'mobile': [3757, 3793], 'eluted': [3760, 4177], 'Luna': [3763], 'C18–2': [3764], 'microbore': [3765], '×': [3768, 3783, 3910, 3913], '100': [3769], 'mm,': [3770, 3785], '5': [3771, 3786, 4061], 'μm;': [3772, 3787], 'Phenomenex,': [3773], 'Torrance,': [3774], 'Beckman': [3778], 'Coulter': [3779], 'Ultrasphere': [3780], '(4.6': [3782], '250': [3784], 'Phenomenex)': [3788], 'gradient': [3792, 3819], 'systems': [3795], 'consisted': [3797], 'methanol/acetonitrile/water/acetate': [3799], '(24:27:49:1,': [3800], 'v/v/v/v,': [3801], 'pH': [3802, 4140], '5.6)': [3803], 'methanol/water/acetate': [3805], '(65:35:0.01,': [3806], 'v/v/v)': [3807], 'run': [3808], 'isocratically': [3809], '25': [3811], 'min': [3812, 4120], '25-min': [3817], 'linear': [3818], '99:1': [3821], '99.99:0.01': [3823], '(v/v,': [3824], 'methanol/acetate),': [3825], 'respectively.': [3826], 'Collected': [3827], 'UV': [3828], 'data': [3829, 4293], 'recalled': [3831], '205,': [3833], '236,': [3834], '270,': [3835], '245,': [3836], '280,': [3837], '301': [3839], 'nm': [3840], 'LC': [3844], '3D': [3845], 'ChemStation': [3846], 'Technologies).': [3849, 3924, 4160], 'compound,': [3856], 'peak': [3858], 'areas': [3859], 'integrated': [3861], 'quantitation.': [3863], 'GC/MS': [3864, 3987], 'Ref.': [3870], 'Scholar': [3895], '6890N': [3898], 'GC': [3899], 'HP5MS': [3903], 'cross-linked': [3904], 'ME': [3905], 'siloxane': [3906], '(30': [3908], 'm': [3909], '0.25': [3911, 3914], 'mm': [3912, 4038], 'μm),': [3915], 'autosampler,': [3917], '5973N': [3920], 'mass-selective': [3921], 'detector': [3922], 'helium': [3926], 'flow': [3927], '1.5': [3930], 'ml/min,': [3931], 'initial': [3934], 'temperature': [3935], '150': [3937], '°C,': [3938, 4050], '230': [3941], '(2': [3943, 4290], 'min)': [3944, 4052], '280': [3946], '(10': [3948], 'min).': [3949], 'For': [3950, 3989], 'selected': [3951], 'samples,': [3952], 'fractions': [3954, 4190], 'correspond': [3956], 'retention': [3959], 'authentic': [3962], 'standards': [3963], 'derivatized': [3967], 'pentafluorobenzyl': [3970], 'esters': [3971], 'trimethylsilyl': [3973], 'ether': [3974], 'derivatives,': [3975], '10–1000': [3977], 'pg': [3978], 'μl': [3983], 'iso-octane': [3985], 'analysis.': [3988], 'product': [3991], 'analysis,': [3992], 'cold': [4002], 'calcium': [4006, 4058, 4314], 'magnesium,': [4008], 'tissue,': [4018], 'MeOH': [4025, 4203], '(injured': [4026], 'corneas)': [4027], '7.4,': [4033], '37': [4034], '1.2': [4037], 'Ca2+.': [4039], 'Uninjured': [4040], 'incubated': [4045], '(37': [4049], '30': [4051, 4119], 'presence': [4055], 'ionophore': [4059], '(A23187;': [4060], 'μm).': [4062], 'Prostaglandin': [4063], 'B2': [4064], 'ng)': [4066], 'added': [4068], 'samples': [4070, 4147, 4218], 'internal': [4073], 'recovery,': [4076], 'gently': [4080], 'extracted': [4086, 4217], 'detailed': [4089], '(53Gronert': [4090], 'Romano': [4094], 'Methods': [4098], 'Mol.': [4099], '120:': [4102], '119-144PubMed': [4103], 'suspensions': [4110], '-20': [4114], 'least': [4118], 'centrifuged,': [4122], 'supernatants': [4124], 'collected.': [4126], 'Supernatants': [4127], 'diluted': [4129], 'volumes': [4132], 'grade': [4135, 4169], 'water': [4136, 4170], 'acidified': [4138], '4.0': [4141], 'HCl': [4143], 'n).': [4145], 'Acidified': [4146], 'loaded': [4150], 'onto': [4151], 'primed': [4152], 'C18-ODS': [4153], 'cartridges': [4154], '(AccuBond': [4155], 'II;': [4156], '500': [4157], 'mg;': [4158], 'Cartridges': [4161], 'washed': [4163], 'ml': [4166], 'hexane,': [4173], 'compounds': [4175], 'methyl': [4179], 'formate': [4180, 4189, 4222], 'final': [4184], 'elution': [4185], 'methanol.': [4187], 'Methyl': [4188], 'dryness': [4194, 4227], 'gentle': [4197, 4230], 'stream': [4198, 4231], 'nitrogen,': [4200, 4233], 'resuspended': [4201, 4234], '(100': [4204], 'μl),': [4205], 'stored': [4207], '-80': [4209], '°C.': [4210], 'autacoids,': [4216], 'methanol': [4220], '(methyl': [4221], 'fractions)': [4223], 'ELISA': [4236], 'buffer,': [4237], 'ELISAs': [4243], '(54Levy': [4246], 'Bertram': [4248], 'Tai': [4250], 'H.H.': [4251], 'Israel': [4252], 'Fischer': [4254], '1993;': [4261], '28:': [4262], '1047-1053Crossref': [4263], '(52)': [4266], '(Neogen,': [4269], 'Lexington,': [4270], 'KY),': [4271], '(Cayman': [4275], 'Chemical,': [4276], 'Ann': [4277], 'Arbor,': [4278], 'MI)': [4279], "manufacturers'": [4283], 'instructions.': [4284], 'per': [4292], 'point)': [4294], 'ice': [4300], 'protease': [4305], 'inhibitor': [4306], 'mixture': [4307], '(Complete': [4308], 'Mini;': [4309], 'Roche': [4310], 'Applied': [4311], 'Science)': [4312], 'magnesium.': [4316], 'Cell': [4317], 'debris': [4318], 'cen': [4322]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2061167233', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 21}, {'year': 2013, 'cited_by_count': 20}, {'year': 2012, 'cited_by_count': 19}], 'updated_date': '2024-12-24T14:53:43.023107', 'created_date': '2016-06-24'}
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