Title: Lipid Mediators in Acute Inflammation and Resolution: Eicosanoids, PAF, Resolvins, and Protectins
Abstract: Autacoids are locally acting substances that are rapidly biosynthesized in response to specific stimuli, act quickly, and are usually deactivated by metabolism. Eicosanoids are a chemically diverse family of arachidonic acid–derived autacoids that have critical roles in cardiovascular, inflammatory, and reproductive physiology. Pharmacologic interventions in eicosanoid pathways – including the nonsteroidal anti-inflammatory drugs (NSAIDs), COX-2 inhibitors, and leukotriene inhibitors – are useful in the clinical management of inflammation, pain, and fever. Given the many important bioactivities of lipid mediator eicosanoids, resolvins, and protectins, future research may lead to the development of new therapeutics for the treatment of inflammatory conditions, autoimmune diseases, asthma, glomerulonephritis, cancer, sleep disorders, and Alzheimer's disease.
Publication Year: 2010
Publication Date: 2010-04-26
Language: en
Type: book-chapter
Indexed In: ['crossref']
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Cited By Count: 17
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