Publication Information

{'id': 'https://openalex.org/W2060935167', 'doi': 'https://doi.org/10.1172/jci973', 'title': 'Distinct mechanisms of platelet aggregation as a consequence of different shearing flow conditions.', 'display_name': 'Distinct mechanisms of platelet aggregation as a consequence of different shearing flow conditions.', 'publication_year': 1998, 'publication_date': '1998-01-15', 'ids': {'openalex': 'https://openalex.org/W2060935167', 'doi': 'https://doi.org/10.1172/jci973', 'mag': '2060935167', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9435321', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/508588'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci973', 'pdf_url': 'http://www.jci.org/articles/view/973/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.jci.org/articles/view/973/files/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5037448892', 'display_name': 'Shinya Goto', 'orcid': 'https://orcid.org/0000-0002-6821-1504'}, 'institutions': [{'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'S Goto', 'raw_affiliation_strings': ['Roon Research Center for Arteriosclerosis and Thrombosis, The Scripps Research Institute, La Jolla, California 92037, USA.'], 'affiliations': [{'raw_affiliation_string': 'Roon Research Center for Arteriosclerosis and Thrombosis, The Scripps Research Institute, La Jolla, California 92037, USA.', 'institution_ids': ['https://openalex.org/I123431417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5114078012', 'display_name': 'Y. Ikeda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1314466530', 'display_name': 'Tokai University', 'ror': 'https://ror.org/01p7qe739', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I1314466530']}, {'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}, {'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP', 'US'], 'is_corresponding': False, 'raw_author_name': 'Y Ikeda', 'raw_affiliation_strings': ['Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.', 'Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan; Ya-', 'Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine and Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037', 'The Scripps Research Institute, SBR-8, 10550 N. Torrey Pines Road, La Jolla, CA 92037.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan; Ya-', 'institution_ids': ['https://openalex.org/I1314466530']}, {'raw_affiliation_string': 'The Scripps Research Institute, SBR-8, 10550 N. Torrey Pines Road, La Jolla, CA 92037.', 'institution_ids': ['https://openalex.org/I123431417']}, {'raw_affiliation_string': 'Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine and Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037', 'institution_ids': ['https://openalex.org/I123431417']}, {'raw_affiliation_string': 'Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.', 'institution_ids': ['https://openalex.org/I203951103']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084760433', 'display_name': 'Enrique Saldı́var', 'orcid': 'https://orcid.org/0009-0001-0331-9151'}, 'institutions': [{'id': 'https://openalex.org/I1314466530', 'display_name': 'Tokai University', 'ror': 'https://ror.org/01p7qe739', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I1314466530']}, {'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}, {'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP', 'US'], 'is_corresponding': False, 'raw_author_name': 'E Saldívar', 'raw_affiliation_strings': ['Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.', 'Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan; Ya-', 'Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine and Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037', 'The Scripps Research Institute, SBR-8, 10550 N. Torrey Pines Road, La Jolla, CA 92037.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan; Ya-', 'institution_ids': ['https://openalex.org/I1314466530']}, {'raw_affiliation_string': 'The Scripps Research Institute, SBR-8, 10550 N. Torrey Pines Road, La Jolla, CA 92037.', 'institution_ids': ['https://openalex.org/I123431417']}, {'raw_affiliation_string': 'Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine and Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037', 'institution_ids': ['https://openalex.org/I123431417']}, {'raw_affiliation_string': 'Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.', 'institution_ids': ['https://openalex.org/I203951103']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5084109223', 'display_name': 'Zaverio M. Ruggeri', 'orcid': 'https://orcid.org/0000-0003-0807-1295'}, 'institutions': [{'id': 'https://openalex.org/I1314466530', 'display_name': 'Tokai University', 'ror': 'https://ror.org/01p7qe739', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I1314466530']}, {'id': 'https://openalex.org/I123431417', 'display_name': 'Scripps Research Institute', 'ror': 'https://ror.org/02dxx6824', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I123431417']}, {'id': 'https://openalex.org/I203951103', 'display_name': 'Keio University', 'ror': 'https://ror.org/02kn6nx58', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I203951103']}], 'countries': ['JP', 'US'], 'is_corresponding': True, 'raw_author_name': 'Z M Ruggeri', 'raw_affiliation_strings': ['Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.', 'Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan; Ya-', 'Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine and Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037', 'The Scripps Research Institute, SBR-8, 10550 N. Torrey Pines Road, La Jolla, CA 92037.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan; Ya-', 'institution_ids': ['https://openalex.org/I1314466530']}, {'raw_affiliation_string': 'The Scripps Research Institute, SBR-8, 10550 N. Torrey Pines Road, La Jolla, CA 92037.', 'institution_ids': ['https://openalex.org/I123431417']}, {'raw_affiliation_string': 'Research Center for Arteriosclerosis and Thrombosis, Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine and Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037', 'institution_ids': ['https://openalex.org/I123431417']}, {'raw_affiliation_string': 'Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.', 'institution_ids': ['https://openalex.org/I203951103']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5084109223'], 'corresponding_institution_ids': ['https://openalex.org/I1314466530', 'https://openalex.org/I123431417', 'https://openalex.org/I203951103'], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 8.918, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 286, 'citation_normalized_percentile': {'value': 0.99971, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '101', 'issue': '2', 'first_page': '479', 'last_page': '486'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Cell Adhesion Molecules Research', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12352', 'display_name': 'Heparin-Induced Thrombocytopenia and Thrombosis', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/platelet-adhesiveness', 'display_name': 'Platelet adhesiveness', 'score': 0.4880065}, {'id': 'https://openalex.org/keywords/glycoprotein-ib', 'display_name': 'Glycoprotein Ib', 'score': 0.4345766}], 'concepts': [{'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.6608834}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6394228}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.6124656}, {'id': 'https://openalex.org/C2778589496', 'wikidata': 'https://www.wikidata.org/wiki/Q487937', 'display_name': 'Hemostasis', 'level': 2, 'score': 0.5974166}, {'id': 'https://openalex.org/C2779036427', 'wikidata': 'https://www.wikidata.org/wiki/Q381899', 'display_name': 'Fibrinogen', 'level': 2, 'score': 0.5161511}, {'id': 'https://openalex.org/C195687474', 'wikidata': 'https://www.wikidata.org/wiki/Q409715', 'display_name': 'Integrin', 'level': 3, 'score': 0.5023217}, {'id': 'https://openalex.org/C2780009322', 'wikidata': 'https://www.wikidata.org/wiki/Q7202246', 'display_name': 'Platelet adhesiveness', 'level': 4, 'score': 0.4880065}, {'id': 'https://openalex.org/C2778442980', 'wikidata': 'https://www.wikidata.org/wiki/Q17110527', 'display_name': 'Glycoprotein Ib', 'level': 4, 'score': 0.4345766}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43312168}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.3911134}, {'id': 'https://openalex.org/C2993802102', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet aggregation', 'level': 3, 'score': 0.3664372}, {'id': 'https://openalex.org/C26828662', 'wikidata': 'https://www.wikidata.org/wiki/Q7202248', 'display_name': 'Platelet membrane glycoprotein', 'level': 3, 'score': 0.30757958}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.27477956}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.27449834}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.22873574}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.20066935}], 'mesh': [{'descriptor_ui': 'D010974', 'descriptor_name': 'Platelet Aggregation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001775', 'descriptor_name': 'Blood Circulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005340', 'descriptor_name': 'Fibrinogen', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D005340', 'descriptor_name': 'Fibrinogen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015539', 'descriptor_name': 'Platelet Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019039', 'descriptor_name': 'Platelet Glycoprotein GPIIb-IIIa Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019039', 'descriptor_name': 'Platelet Glycoprotein GPIIb-IIIa Complex', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D019038', 'descriptor_name': 'Platelet Glycoprotein GPIb-IX Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019038', 'descriptor_name': 'Platelet Glycoprotein GPIb-IX Complex', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D013927', 'descriptor_name': 'Thrombosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013927', 'descriptor_name': 'Thrombosis', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D014841', 'descriptor_name': 'von Willebrand Factor', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D014841', 'descriptor_name': 'von Willebrand Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci973', 'pdf_url': 'http://www.jci.org/articles/view/973/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc508588', 'pdf_url': 'https://europepmc.org/articles/pmc508588?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC508588', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9435321', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci973', 'pdf_url': 'http://www.jci.org/articles/view/973/files/pdf', 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1512144932', 'https://openalex.org/W1534508763', 'https://openalex.org/W1537495273', 'https://openalex.org/W1555561206', 'https://openalex.org/W1561189761', 'https://openalex.org/W1598021300', 'https://openalex.org/W1600368065', 'https://openalex.org/W1601949983', 'https://openalex.org/W160258599', 'https://openalex.org/W16151995', 'https://openalex.org/W1924175076', 'https://openalex.org/W1966286149', 'https://openalex.org/W1970959909', 'https://openalex.org/W1987174800', 'https://openalex.org/W1992646081', 'https://openalex.org/W1993486440', 'https://openalex.org/W2015695912', 'https://openalex.org/W2016566683', 'https://openalex.org/W2051446149', 'https://openalex.org/W2075013504', 'https://openalex.org/W2078314103', 'https://openalex.org/W2084785484', 'https://openalex.org/W2134808987', 'https://openalex.org/W2140010130', 'https://openalex.org/W2165207329', 'https://openalex.org/W2169030528', 'https://openalex.org/W2171721261', 'https://openalex.org/W2227357774', 'https://openalex.org/W2259700787', 'https://openalex.org/W2263006099', 'https://openalex.org/W2270564137', 'https://openalex.org/W2294445537', 'https://openalex.org/W2335477357', 'https://openalex.org/W2444380280', 'https://openalex.org/W286388493', 'https://openalex.org/W2980015831', 'https://openalex.org/W4232951323', 'https://openalex.org/W4236716040', 'https://openalex.org/W4237471765', 'https://openalex.org/W4243291132', 'https://openalex.org/W4245085856', 'https://openalex.org/W4245198552', 'https://openalex.org/W4246702083', 'https://openalex.org/W4254742516', 'https://openalex.org/W4361865076'], 'related_works': ['https://openalex.org/W4241503690', 'https://openalex.org/W311984662', 'https://openalex.org/W2886504686', 'https://openalex.org/W2573943065', 'https://openalex.org/W2203090688', 'https://openalex.org/W2150357452', 'https://openalex.org/W2046578569', 'https://openalex.org/W2018209661', 'https://openalex.org/W2002135630', 'https://openalex.org/W1905987095'], 'abstract_inverted_index': {'Platelet': [0, 73], 'aggregation': [1, 92, 177], 'contributes': [2], 'to': [3, 20, 24, 37, 61, 69, 100, 106, 134, 145, 153], 'arresting': [4], 'bleeding': [5], 'at': [6], 'wound': [7], 'sites,': [8], 'but': [9, 89], 'may': [10, 57], 'cause': [11], 'occlusion': [12], 'of': [13, 157, 171, 188], 'atherosclerotic': [14], 'vessels,': [15], 'thus': [16], 'curtailing': [17], 'blood': [18], 'flow': [19, 53], 'vital': [21], 'organs.': [22], 'According': [23], 'current': [25, 186], 'dogma,': [26], 'the': [27, 95, 125, 141, 155, 168, 185], 'integrin': [28], 'alphaIIbbeta3': [29, 66, 126], 'plays': [30], 'an': [31], 'exclusive': [32], 'role': [33], 'in': [34, 91, 192], 'linking': [35], 'platelets': [36, 104], 'one': [38], 'another': [39], 'through': [40], 'interactions': [41], 'with': [42, 87, 149], 'fibrinogen': [43, 123], 'or': [44], 'vWf.': [45], 'We': [46], 'demonstrate': [47], 'here': [48], 'that,': [49], 'depending': [50], 'on': [51], 'shearing': [52], 'conditions,': [54, 182], 'this': [55], 'process': [56], 'require': [58], 'vWf': [59, 132], 'binding': [60, 133], 'glycoprotein': [62, 84, 135], 'Ibalpha,': [63], 'even': [64], 'when': [65, 122], 'is': [67, 81, 124], 'competent': [68], 'bind': [70, 98], 'adhesive': [71, 127, 173], 'ligands.': [72], 'activation': [74, 111], 'induced': [75], 'solely': [76], 'by': [77, 83, 112], 'high': [78, 107, 158], 'shear': [79, 108, 159], 'stress': [80], 'initiated': [82], 'Ibalpha': [85, 136], 'interaction': [86, 143], 'vWf,': [88], 'results': [90], 'only': [93, 130], 'if': [94, 131], 'latter': [96, 142], 'can': [97, 120, 137], 'concurrently': [99], 'alphaIIbbeta3.': [101], 'In': [102], 'contrast,': [103], 'exposed': [105], 'rate': [109, 160], 'after': [110], 'exogenous': [113], 'agonists': [114], 'such': [115], 'as': [116], 'ADP': [117], 'and': [118, 161, 183, 194], 'epinephrine': [119], 'aggregate': [121], 'ligand,': [128], 'yet': [129], 'also': [138], 'occur.': [139], 'Thus,': [140], 'appears': [144], 'provide': [146], 'a': [147, 189], 'bond': [148], 'biomechanical': [150], 'properties': [151], 'necessary': [152], 'overcome': [154], 'effects': [156], 'initiate': [162], 'interplatelet': [163], 'cohesion.': [164], 'These': [165], 'findings': [166], 'highlight': [167], 'distinct': [169], 'function': [170], 'two': [172], 'receptors': [174], 'mediating': [175], 'platelet': [176], 'under': [178], 'varying': [179], 'fluid': [180], 'dynamic': [181], 'modify': [184], 'interpretation': [187], 'crucial': [190], 'event': [191], 'hemostasis': [193], 'thrombosis.': [195]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2060935167', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-13T19:06:00.197021', 'created_date': '2016-06-24'}