Inhibition of Platelet Glycoprotein Ib and Its Antithrombotic Potential

Name: Work Video:
Duration: 3 min 30 s
Karen Vanhoorelbeke; Hans Ulrichts; Gerlinde R. Van de Walle; Alexandre Fontayne; Hans Deckmyn
{'id': 'https://openalex.org/W2150357452', 'doi': 'https://doi.org/10.2174/138161207781662867', 'title': 'Inhibition of Platelet Glycoprotein Ib and Its Antithrombotic Potential', 'display_name': 'Inhibition of Platelet Glycoprotein Ib and Its Antithrombotic Potential', 'publication_year': 2007, 'publication_date': '2007-08-28', 'ids': {'openalex': 'https://openalex.org/W2150357452', 'doi': 'https://doi.org/10.2174/138161207781662867', 'mag': '2150357452', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17897012'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/138161207781662867', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S55674637', 'display_name': 'Current Pharmaceutical Design', 'issn_l': '1381-6128', 'issn': ['1381-6128', '1873-4286'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010065750', 'display_name': 'Karen Vanhoorelbeke', 'orcid': 'https://orcid.org/0000-0003-2288-8277'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Karen Vanhoorelbeke', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056713280', 'display_name': 'Hans Ulrichts', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210101017', 'display_name': 'Research Institute for Chromatography', 'ror': 'https://ror.org/00yhmjd28', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210101017']}, {'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': True, 'raw_author_name': 'Hans Ulrichts', 'raw_affiliation_strings': ['Laboratory for Thrombosis Research, IRC, KU Leuven Campus Kortrijk, E. Sabbelaan 53 8500 Kortrijk, Belgium.,Belgium'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Thrombosis Research, IRC, KU Leuven Campus Kortrijk, E. Sabbelaan 53 8500 Kortrijk, Belgium.,Belgium', 'institution_ids': ['https://openalex.org/I4210101017', 'https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074374287', 'display_name': 'Gerlinde R. Van de Walle', 'orcid': 'https://orcid.org/0000-0002-2064-8029'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Gerlinde de Walle', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047345459', 'display_name': 'Alexandre Fontayne', 'orcid': 'https://orcid.org/0000-0002-0097-2294'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Alexandre Fontayne', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5022448402', 'display_name': 'Hans Deckmyn', 'orcid': 'https://orcid.org/0000-0003-3952-5501'}, 'institutions': [{'id': 'https://openalex.org/I4210101017', 'display_name': 'Research Institute for Chromatography', 'ror': 'https://ror.org/00yhmjd28', 'country_code': 'BE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210101017']}, {'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': True, 'raw_author_name': 'Hans Deckmyn', 'raw_affiliation_strings': ['Laboratory for Thrombosis Research, IRC, KU Leuven Campus Kortrijk, E. Sabbelaan 53 8500 Kortrijk, Belgium.,Belgium'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Thrombosis Research, IRC, KU Leuven Campus Kortrijk, E. Sabbelaan 53 8500 Kortrijk, Belgium.,Belgium', 'institution_ids': ['https://openalex.org/I4210101017', 'https://openalex.org/I99464096']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5056713280', 'https://openalex.org/A5022448402'], 'corresponding_institution_ids': ['https://openalex.org/I4210101017', 'https://openalex.org/I99464096', 'https://openalex.org/I4210101017', 'https://openalex.org/I99464096'], 'apc_list': None, 'apc_paid': None, 'fwci': 1.055, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 48, 'citation_normalized_percentile': {'value': 0.714165, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '13', 'issue': '26', 'first_page': '2684', 'last_page': '2697'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Treatments', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10746', 'display_name': 'Platelet Disorders and Treatments', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11917', 'display_name': 'Coagulation, Bradykinin, Polyphosphates, and Angioedema', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10881', 'display_name': 'Blood Coagulation and Thrombosis Mechanisms', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/glycoprotein-ib', 'display_name': 'Glycoprotein Ib', 'score': 0.6087106}, {'id': 'https://openalex.org/keywords/high-molecular-weight-kininogen', 'display_name': 'High-molecular-weight kininogen', 'score': 0.56990874}, {'id': 'https://openalex.org/keywords/platelet-adhesiveness', 'display_name': 'Platelet adhesiveness', 'score': 0.53723085}], 'concepts': [{'id': 'https://openalex.org/C2779394231', 'wikidata': 'https://www.wikidata.org/wiki/Q412310', 'display_name': 'Von Willebrand factor', 'level': 3, 'score': 0.83914685}, {'id': 'https://openalex.org/C89560881', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet', 'level': 2, 'score': 0.7909237}, {'id': 'https://openalex.org/C26828662', 'wikidata': 'https://www.wikidata.org/wiki/Q7202248', 'display_name': 'Platelet membrane glycoprotein', 'level': 3, 'score': 0.6950818}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.68486536}, {'id': 'https://openalex.org/C2910597130', 'wikidata': 'https://www.wikidata.org/wiki/Q17156451', 'display_name': 'Platelet Glycoprotein GPIb-IX Complex', 'level': 4, 'score': 0.6466173}, {'id': 'https://openalex.org/C2778442980', 'wikidata': 'https://www.wikidata.org/wiki/Q17110527', 'display_name': 'Glycoprotein Ib', 'level': 4, 'score': 0.6087106}, {'id': 'https://openalex.org/C108625454', 'wikidata': 'https://www.wikidata.org/wiki/Q187126', 'display_name': 'Glycoprotein', 'level': 2, 'score': 0.60364115}, {'id': 'https://openalex.org/C2778382381', 'wikidata': 'https://www.wikidata.org/wiki/Q179217', 'display_name': 'Coagulation', 'level': 2, 'score': 0.5856421}, {'id': 'https://openalex.org/C2777015399', 'wikidata': 'https://www.wikidata.org/wiki/Q4775337', 'display_name': 'Antithrombotic', 'level': 2, 'score': 0.5701963}, {'id': 'https://openalex.org/C2781317560', 'wikidata': 'https://www.wikidata.org/wiki/Q24721273', 'display_name': 'High-molecular-weight kininogen', 'level': 5, 'score': 0.56990874}, {'id': 'https://openalex.org/C2781362458', 'wikidata': 'https://www.wikidata.org/wiki/Q1588755', 'display_name': 'Thrombus', 'level': 2, 'score': 0.5419231}, {'id': 'https://openalex.org/C2780009322', 'wikidata': 'https://www.wikidata.org/wiki/Q7202246', 'display_name': 'Platelet adhesiveness', 'level': 4, 'score': 0.53723085}, {'id': 'https://openalex.org/C195687474', 'wikidata': 'https://www.wikidata.org/wiki/Q409715', 'display_name': 'Integrin', 'level': 3, 'score': 0.524031}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.47130263}, {'id': 'https://openalex.org/C159973064', 'wikidata': 'https://www.wikidata.org/wiki/Q3740205', 'display_name': 'Platelet factor 4', 'level': 3, 'score': 0.4509579}, {'id': 'https://openalex.org/C3018697912', 'wikidata': 'https://www.wikidata.org/wiki/Q179217', 'display_name': 'Platelet activation', 'level': 3, 'score': 0.4305539}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.427467}, {'id': 'https://openalex.org/C2777292125', 'wikidata': 'https://www.wikidata.org/wiki/Q409166', 'display_name': 'Thrombin', 'level': 3, 'score': 0.42338702}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.35914177}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.29785413}, {'id': 'https://openalex.org/C2777902427', 'wikidata': 'https://www.wikidata.org/wiki/Q6413860', 'display_name': 'Kininogen', 'level': 4, 'score': 0.24261966}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.23399273}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1819677}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.15857527}, {'id': 'https://openalex.org/C2993802102', 'wikidata': 'https://www.wikidata.org/wiki/Q101026', 'display_name': 'Platelet aggregation', 'level': 3, 'score': 0.07363349}, {'id': 'https://openalex.org/C2779591629', 'wikidata': 'https://www.wikidata.org/wiki/Q24745328', 'display_name': 'Bradykinin', 'level': 3, 'score': 0.066488326}], 'mesh': [{'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D005343', 'descriptor_name': 'Fibrinolytic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019038', 'descriptor_name': 'Platelet Glycoprotein GPIb-IX Complex', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D013927', 'descriptor_name': 'Thrombosis', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001792', 'descriptor_name': 'Blood Platelets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005343', 'descriptor_name': 'Fibrinolytic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005343', 'descriptor_name': 'Fibrinolytic Agents', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D005343', 'descriptor_name': 'Fibrinolytic Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019038', 'descriptor_name': 'Platelet Glycoprotein GPIb-IX Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019038', 'descriptor_name': 'Platelet Glycoprotein GPIb-IX Complex', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019038', 'descriptor_name': 'Platelet Glycoprotein GPIb-IX Complex', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010980', 'descriptor_name': 'Platelet Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010980', 'descriptor_name': 'Platelet Membrane Glycoproteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D010980', 'descriptor_name': 'Platelet Membrane Glycoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010980', 'descriptor_name': 'Platelet Membrane Glycoproteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013927', 'descriptor_name': 'Thrombosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013927', 'descriptor_name': 'Thrombosis', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D013927', 'descriptor_name': 'Thrombosis', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/138161207781662867', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S55674637', 'display_name': 'Current Pharmaceutical Design', 'issn_l': '1381-6128', 'issn': ['1381-6128', '1873-4286'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17897012', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 188, 'referenced_works': ['https://openalex.org/W123749191', 'https://openalex.org/W143880323', 'https://openalex.org/W1492746912', 'https://openalex.org/W1498789585', 'https://openalex.org/W1518197977', 'https://openalex.org/W1529873450', 'https://openalex.org/W1542837635', 'https://openalex.org/W1543884598', 'https://openalex.org/W1548847180', 'https://openalex.org/W1549461809', 'https://openalex.org/W1550445291', 'https://openalex.org/W1563492198', 'https://openalex.org/W1572786395', 'https://openalex.org/W1579308444', 'https://openalex.org/W1587717751', 'https://openalex.org/W1590061014', 'https://openalex.org/W1598021300', 'https://openalex.org/W1602599685', 'https://openalex.org/W1615731206', 'https://openalex.org/W1616191186', 'https://openalex.org/W1644153661', 'https://openalex.org/W164651796', 'https://openalex.org/W168982357', 'https://openalex.org/W1811402656', 'https://openalex.org/W1828989025', 'https://openalex.org/W1837360856', 'https://openalex.org/W1838407374', 'https://openalex.org/W1888609755', 'https://openalex.org/W1963932041', 'https://openalex.org/W1964151860', 'https://openalex.org/W1964499190', 'https://openalex.org/W1965184869', 'https://openalex.org/W1969786740', 'https://openalex.org/W1970246174', 'https://openalex.org/W1970959706', 'https://openalex.org/W1971045715', 'https://openalex.org/W1971596159', 'https://openalex.org/W1971857408', 'https://openalex.org/W1972704690', 'https://openalex.org/W1973043594', 'https://openalex.org/W1974172048', 'https://openalex.org/W1977487002', 'https://openalex.org/W1978785828', 'https://openalex.org/W1983735248', 'https://openalex.org/W1984464853', 'https://openalex.org/W1987174800', 'https://openalex.org/W1988580831', 'https://openalex.org/W1990386018', 'https://openalex.org/W1990625704', 'https://openalex.org/W1992989611', 'https://openalex.org/W1995421768', 'https://openalex.org/W2002135630', 'https://openalex.org/W2002321751', 'https://openalex.org/W2002715335', 'https://openalex.org/W2002943688', 'https://openalex.org/W200349053', 'https://openalex.org/W2003648675', 'https://openalex.org/W2004721076', 'https://openalex.org/W2006006858', 'https://openalex.org/W2007417152', 'https://openalex.org/W2008516918', 'https://openalex.org/W2012882322', 'https://openalex.org/W2015038774', 'https://openalex.org/W2016428398', 'https://openalex.org/W2016531738', 'https://openalex.org/W2017873104', 'https://openalex.org/W2017874859', 'https://openalex.org/W2018382750', 'https://openalex.org/W2023458662', 'https://openalex.org/W2024096897', 'https://openalex.org/W2024625411', 'https://openalex.org/W2026855111', 'https://openalex.org/W202768902', 'https://openalex.org/W2028687062', 'https://openalex.org/W2031259374', 'https://openalex.org/W2032277310', 'https://openalex.org/W2032879069', 'https://openalex.org/W2033453659', 'https://openalex.org/W2035845109', 'https://openalex.org/W2036659707', 'https://openalex.org/W2037863911', 'https://openalex.org/W2038583617', 'https://openalex.org/W2041720169', 'https://openalex.org/W2042094123', 'https://openalex.org/W2043083034', 'https://openalex.org/W2044255402', 'https://openalex.org/W2045710773', 'https://openalex.org/W2047985607', 'https://openalex.org/W2050141829', 'https://openalex.org/W2052061149', 'https://openalex.org/W2055524637', 'https://openalex.org/W2056845211', 'https://openalex.org/W2057037941', 'https://openalex.org/W2058417054', 'https://openalex.org/W2061123866', 'https://openalex.org/W2062581256', 'https://openalex.org/W2064724092', 'https://openalex.org/W2066463869', 'https://openalex.org/W2067625954', 'https://openalex.org/W2068322932', 'https://openalex.org/W2069025442', 'https://openalex.org/W2070307942', 'https://openalex.org/W2071119634', 'https://openalex.org/W2071254360', 'https://openalex.org/W2075492999', 'https://openalex.org/W2078200855', 'https://openalex.org/W2078752995', 'https://openalex.org/W2080086114', 'https://openalex.org/W2081075409', 'https://openalex.org/W2081514771', 'https://openalex.org/W2085808764', 'https://openalex.org/W2087350779', 'https://openalex.org/W2089625435', 'https://openalex.org/W2091785640', 'https://openalex.org/W2092422296', 'https://openalex.org/W2092442248', 'https://openalex.org/W2093731263', 'https://openalex.org/W2096326108', 'https://openalex.org/W2101951362', 'https://openalex.org/W2102193620', 'https://openalex.org/W2102324547', 'https://openalex.org/W2104391363', 'https://openalex.org/W2106733037', 'https://openalex.org/W2106803296', 'https://openalex.org/W2109421983', 'https://openalex.org/W2109935864', 'https://openalex.org/W2110007918', 'https://openalex.org/W2110641306', 'https://openalex.org/W2111016073', 'https://openalex.org/W2112030247', 'https://openalex.org/W2112701109', 'https://openalex.org/W2115952305', 'https://openalex.org/W2115956404', 'https://openalex.org/W2121530981', 'https://openalex.org/W2121844388', 'https://openalex.org/W2121859722', 'https://openalex.org/W2121897924', 'https://openalex.org/W2123695942', 'https://openalex.org/W2125010264', 'https://openalex.org/W2128359699', 'https://openalex.org/W2131027010', 'https://openalex.org/W2136877202', 'https://openalex.org/W2136969158', 'https://openalex.org/W2140680091', 'https://openalex.org/W2142320136', 'https://openalex.org/W2142860191', 'https://openalex.org/W2146572848', 'https://openalex.org/W2149935828', 'https://openalex.org/W2150117652', 'https://openalex.org/W2150525984', 'https://openalex.org/W2150717689', 'https://openalex.org/W2152298923', 'https://openalex.org/W2155725197', 'https://openalex.org/W2155911050', 'https://openalex.org/W2158097737', 'https://openalex.org/W2158369873', 'https://openalex.org/W2158551846', 'https://openalex.org/W2160209309', 'https://openalex.org/W2165212561', 'https://openalex.org/W2169030528', 'https://openalex.org/W2170055916', 'https://openalex.org/W2171068060', 'https://openalex.org/W2195745009', 'https://openalex.org/W2210300066', 'https://openalex.org/W2226484723', 'https://openalex.org/W2226999514', 'https://openalex.org/W2246880911', 'https://openalex.org/W2263006099', 'https://openalex.org/W2265690186', 'https://openalex.org/W2292419927', 'https://openalex.org/W2308864913', 'https://openalex.org/W2324841714', 'https://openalex.org/W2399187687', 'https://openalex.org/W2402120089', 'https://openalex.org/W2404846762', 'https://openalex.org/W2409160201', 'https://openalex.org/W2415653215', 'https://openalex.org/W2416425874', 'https://openalex.org/W2425822344', 'https://openalex.org/W2432215871', 'https://openalex.org/W2435424019', 'https://openalex.org/W2463468240', 'https://openalex.org/W2990245264', 'https://openalex.org/W34673264', 'https://openalex.org/W36951521', 'https://openalex.org/W53004749', 'https://openalex.org/W753326633', 'https://openalex.org/W89470292'], 'related_works': ['https://openalex.org/W4248195639', 'https://openalex.org/W4241503690', 'https://openalex.org/W311984662', 'https://openalex.org/W2203090688', 'https://openalex.org/W2154246857', 'https://openalex.org/W2150357452', 'https://openalex.org/W2140680091', 'https://openalex.org/W2093095636', 'https://openalex.org/W2018209661', 'https://openalex.org/W1905987095'], 'abstract_inverted_index': {'The': [0], 'platelet': [1, 15, 74], 'receptor': [2], 'glycoprotein': [3], '(GP)Ib-IX-V': [4], 'complex': [5], 'plays': [6], 'a': [7, 56, 72], 'dominant': [8], 'role': [9], 'in': [10, 64, 68, 134], 'the': [11, 25, 37, 43, 46, 59, 69, 78, 90, 119, 130], 'first': [12, 73], 'steps': [13], 'of': [14, 71, 121], 'adhesion': [16, 66], 'and': [17, 114, 129], 'arterial': [18], 'thrombus': [19, 82], 'formation.': [20, 83], 'Through': [21], 'its': [22, 124], 'interaction': [23, 120], 'with': [24, 123], 'multimeric': [26], 'plasma': [27], 'protein': [28], 'von': [29], 'Willebrand': [30], 'factor': [31, 101, 109], '(VWF),': [32], 'which': [33, 76], 'is': [34, 55, 77, 127], 'bound': [35], 'to': [36, 62], 'damaged': [38], 'subendothelial': [39], 'structures,': [40], 'GPIb-IX-V': [41, 88, 122], 'tethers': [42], 'platelets': [44], 'from': [45], 'flowing': [47], 'blood': [48], 'thereby': [49], 'slowing': [50], 'them': [51], 'down.': [52], 'This': [53], 'step': [54], 'prerequisite': [57], 'for': [58, 80, 87], 'collagen': [60], 'receptors': [61], 'participate': [63], 'firm': [65], 'resulting': [67], 'formation': [70], 'layer': [75], 'basis': [79], 'further': [81], 'Recently,': [84], 'other': [85], 'ligands': [86, 126], 'besides': [89], 'extensively': [91], 'studied': [92], 'VWF': [93], 'have': [94], 'been': [95], 'identified,': [96], 'such': [97], 'as:': [98], 'alpha-thrombin,': [99], 'coagulation': [100], 'XII': [102], '(FXII),': [103], 'high': [104], 'molecular': [105], 'weight': [106], 'kininogen': [107], '(HMWK),': [108], 'XI': [110], '(FXI),': [111], 'integrin': [112], 'Mac-1': [113], 'P-selectin.': [115], 'In': [116], 'this': [117], 'review,': [118], 'different': [125], 'described': [128], 'anticipated': [131], 'or': [132], 'demonstrated': [133], 'vivo': [135], 'effects': [136], 'are': [137], 'discussed.': [138]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2150357452', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-07T19:08:01.578944', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
