Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2060288350', 'doi': 'https://doi.org/10.1111/j.1600-0722.1998.tb02170.x', 'title': 'The bone morphogenetic protein family: multifunctional cellular regulators in the embryo and adult', 'display_name': 'The bone morphogenetic protein family: multifunctional cellular regulators in the embryo and adult', 'publication_year': 1998, 'publication_date': '1998-01-01', 'ids': {'openalex': 'https://openalex.org/W2060288350', 'doi': 'https://doi.org/10.1111/j.1600-0722.1998.tb02170.x', 'mag': '2060288350', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9541220'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1600-0722.1998.tb02170.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S40136177', 'display_name': 'European Journal Of Oral Sciences', 'issn_l': '0909-8836', 'issn': ['0909-8836', '1600-0722'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5088552955', 'display_name': 'John M. Wozney', 'orcid': 'https://orcid.org/0000-0001-5460-6815'}, 'institutions': [{'id': 'https://openalex.org/I4210090529', 'display_name': 'Andover Eye Associates', 'ror': 'https://ror.org/00gb2qm43', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210090529']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'John M. Wozney', 'raw_affiliation_strings': ['Genetics Institute, Andover, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Genetics Institute, Andover, MA, USA', 'institution_ids': ['https://openalex.org/I4210090529']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5088552955'], 'corresponding_institution_ids': ['https://openalex.org/I4210090529'], 'apc_list': {'value': 4020, 'currency': 'USD', 'value_usd': 4020, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.5, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 184, 'citation_normalized_percentile': {'value': 0.889299, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '106', 'issue': 'S1', 'first_page': '160', 'last_page': '166'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10059', 'display_name': 'Bone Tissue Engineering Materials', 'score': 0.9687, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10059', 'display_name': 'Bone Tissue Engineering Materials', 'score': 0.9687, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11501', 'display_name': 'TGF-β signaling in diseases', 'score': 0.9345, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12264', 'display_name': 'Tissue Engineering and Regenerative Medicine', 'score': 0.9181, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/intramembranous-ossification', 'display_name': 'Intramembranous ossification', 'score': 0.8225859}, {'id': 'https://openalex.org/keywords/endochondral-ossification', 'display_name': 'Endochondral ossification', 'score': 0.6096662}], 'concepts': [{'id': 'https://openalex.org/C188945261', 'wikidata': 'https://www.wikidata.org/wiki/Q10746904', 'display_name': 'Intramembranous ossification', 'level': 2, 'score': 0.8225859}, {'id': 'https://openalex.org/C31507581', 'wikidata': 'https://www.wikidata.org/wiki/Q425383', 'display_name': 'Bone morphogenetic protein', 'level': 3, 'score': 0.7428475}, {'id': 'https://openalex.org/C17938293', 'wikidata': 'https://www.wikidata.org/wiki/Q3312710', 'display_name': 'Endochondral ossification', 'level': 3, 'score': 0.6096662}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5154027}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4499088}, {'id': 'https://openalex.org/C30352789', 'wikidata': 'https://www.wikidata.org/wiki/Q14903153', 'display_name': 'Bone morphogenetic protein 2', 'level': 3, 'score': 0.42073834}, {'id': 'https://openalex.org/C199343813', 'wikidata': 'https://www.wikidata.org/wiki/Q12128', 'display_name': 'Dentistry', 'level': 1, 'score': 0.38261533}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.3521583}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.35169628}, {'id': 'https://openalex.org/C2780550940', 'wikidata': 'https://www.wikidata.org/wiki/Q502730', 'display_name': 'Cartilage', 'level': 2, 'score': 0.25632882}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.15370154}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.13226119}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019485', 'descriptor_name': 'Bone Morphogenetic Proteins', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019485', 'descriptor_name': 'Bone Morphogenetic Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D019485', 'descriptor_name': 'Bone Morphogenetic Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019485', 'descriptor_name': 'Bone Morphogenetic Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005314', 'descriptor_name': 'Embryonic and Fetal Development', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D005314', 'descriptor_name': 'Embryonic and Fetal Development', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009805', 'descriptor_name': 'Odontogenesis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D009805', 'descriptor_name': 'Odontogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010012', 'descriptor_name': 'Osteogenesis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D010012', 'descriptor_name': 'Osteogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1111/j.1600-0722.1998.tb02170.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S40136177', 'display_name': 'European Journal Of Oral Sciences', 'issn_l': '0909-8836', 'issn': ['0909-8836', '1600-0722'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9541220', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Life on land', 'score': 0.53, 'id': 'https://metadata.un.org/sdg/15'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W3111436710', 'https://openalex.org/W2979256684', 'https://openalex.org/W2353378266', 'https://openalex.org/W2305606475', 'https://openalex.org/W2284078820', 'https://openalex.org/W2160769459', 'https://openalex.org/W2149581206', 'https://openalex.org/W2039419642', 'https://openalex.org/W2025253407', 'https://openalex.org/W18760785'], 'abstract_inverted_index': {'Originally': [0], 'identified': [1], 'as': [2, 71, 73, 138, 140], 'the': [3, 12, 25, 35, 62, 84, 91, 97, 103, 114, 141, 160, 182, 191], 'active': [4], 'components': [5], 'within': [6, 24], 'osteoinductive': [7], 'extracts': [8], 'derived': [9], 'from': [10, 51, 186], 'bone,': [11, 179], 'BMPs': [13, 85], 'now': [14], 'are': [15, 56], 'known': [16], 'to': [17, 41, 53, 89, 119, 133, 158, 174, 196], 'include': [18], 'a': [19, 128, 171], 'large': [20, 124], 'family': [21, 37], 'of': [22, 28, 34, 64, 83, 99, 116, 130, 150, 193], 'proteins': [23], 'TGF‐β': [26], 'superfamily': [27], 'growth': [29], 'and': [30, 69, 105, 122, 143, 167], 'differentiation': [31], 'factors.': [32], 'Members': [33], 'BMP': [36], 'have': [38, 86, 112], 'been': [39, 87, 156], 'determined': [40], 'be': [42], 'key': [43], 'signaling': [44], 'molecules': [45], 'in': [46, 48, 58, 96, 127, 136, 163, 170], 'embryogenesis,': [47], 'species': [49], 'ranging': [50], 'Drosophila': [52], 'humans.': [54], 'They': [55], 'involved': [57], 'delivering': [59], 'positional': [60], 'information,': [61], 'development': [63], 'hard': [65], 'tissues': [66], '(both': [67], 'bones': [68], 'teeth),': [70], 'well': [72, 139], 'soft': [74], 'tissue': [75], 'types.': [76], 'When': [77], 'implanted': [78], 'into': [79], 'adult': [80], 'animals,': [81], 'several': [82, 164], 'shown': [88, 113, 157], 'initiate': [90], 'complex': [92], 'cellular': [93], 'process': [94], 'resulting': [95], 'induction': [98], 'bone': [100, 107, 121], 'through': [101], 'both': [102], 'endochondral': [104], 'intramembranous': [106], 'formation': [108], 'pathways.': [109], 'Preclinical': [110], 'studies': [111, 189], 'ability': [115, 192], 'these': [117], 'factors': [118], 'induce': [120, 197], 'heal': [123], 'bony': [125], 'defects': [126], 'variety': [129], 'models': [131], 'relevant': [132], 'clinical': [134, 188], 'problems': [135], 'orthopedics,': [137], 'oral': [142], 'maxillofacial': [144], 'dental': [145], 'areas.': [146], 'For': [147], 'example,': [148], 'implantation': [149], 'recombinant': [151], 'human': [152], 'BMP‐2': [153], '(rhBMP‐2)': [154], 'has': [155], 'augment': [159], 'alveolar': [161], 'ridge': [162], 'animal': [165], 'models,': [166], 'when': [168], 'placed': [169], 'periodontal': [172], 'environment': [173], 'restore': [175], 'not': [176], 'only': [177], 'new': [178], 'but': [180], 'also': [181], 'attachment': [183], 'tissues.': [184], 'Results': [185], 'ongoing': [187], 'support': [190], 'rhBMP‐2': [194], 'implants': [195], 'physiologic': [198], 'bone.': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2060288350', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-10T13:47:42.468599', 'created_date': '2016-06-24'}