Publication Information

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'https://openalex.org/W2162815565', 'https://openalex.org/W2139018071', 'https://openalex.org/W2068781633', 'https://openalex.org/W2025628875', 'https://openalex.org/W2020377057', 'https://openalex.org/W1966337931', 'https://openalex.org/W1621864303', 'https://openalex.org/W1606577628', 'https://openalex.org/W1578243658'], 'abstract_inverted_index': {'The': [0, 182, 364, 941, 2186, 2200, 2731, 2965, 4543, 4788, 4862, 4938], 'familial': [1, 150, 183, 332], "Alzheimer's": [2, 151, 180, 184, 333, 362, 381, 530], 'disease': [3, 152, 185, 334, 531], 'gene': [4, 57, 64, 73, 128, 186, 239, 246, 255, 310, 870, 944, 1638, 3325, 3354, 3403, 3442, 3459, 3555, 3603, 3686, 3761, 3799, 3894, 3906, 4364, 4647, 4703, 4873], 'product': [5, 187, 4550], 'β-amyloid': [6, 87, 188, 269], '(Aβ)': [7, 189], 'precursor': [8, 190, 372], 'protein': [9, 191, 2939, 3296, 5087], '(APP)': [10, 192], 'is': [11, 29, 193, 211, 585, 612, 624, 641, 669, 929, 945, 976, 1085, 1547, 1608, 2626, 2632, 2648, 2652, 2734, 3137, 3153, 3215, 3230, 3444, 3456, 3599, 3885, 4465, 4489, 4493, 4522, 4551, 4569, 4819, 4921, 5151], 'processed': [12, 97, 194, 279, 1600, 3261], 'by': [13, 98, 112, 195, 280, 294, 576, 588, 603, 615, 681, 868, 882, 921, 1303, 1671, 1745, 1767, 1778, 1855, 1941, 1973, 2036, 2051, 2065, 2120, 2235, 2792, 2935, 2942, 3053, 3076, 3262, 3274, 3424, 3447, 3874, 4386, 4599, 4651, 4742, 4796, 4917, 4951, 5190], 'the': [14, 32, 44, 79, 84, 99, 107, 144, 160, 164, 174, 196, 214, 226, 261, 266, 281, 289, 326, 342, 346, 356, 516, 577, 589, 604, 616, 619, 625, 629, 634, 645, 650, 659, 664, 693, 759, 888, 922, 935, 1052, 1089, 1094, 1100, 1113, 1310, 1315, 1331, 1334, 1353, 1424, 1432, 1440, 1539, 1565, 1574, 1596, 1620, 1625, 1650, 1674, 1741, 1769, 1775, 1781, 1786, 1863, 1907, 1920, 1962, 2042, 2067, 2073, 2124, 2244, 2566, 2582, 2586, 2591, 2608, 2636, 2640, 2644, 2658, 2696, 2705, 2718, 2722, 2748, 2752, 2775, 2779, 2787, 2864, 2887, 2900, 2926, 2957, 3055, 3077, 3088, 3093, 3106, 3134, 3150, 3162, 3178, 3243, 3257, 3263, 3271, 3320, 3338, 3364, 3368, 3393, 3401, 3425, 3467, 3549, 3560, 3566, 3619, 3638, 3697, 3706, 3721, 3736, 3752, 3766, 3779, 3783, 3816, 3824, 3846, 3869, 3878, 3882, 3902, 3918, 3978, 3991, 4009, 4047, 4054, 4063, 4071, 4092, 4101, 4118, 4124, 4137, 4146, 4148, 4158, 4172, 4179, 4205, 4218, 4228, 4249, 4256, 4289, 4305, 4328, 4332, 4339, 4343, 4360, 4370, 4400, 4421, 4459, 4480, 4499, 4506, 4516, 4519, 4525, 4528, 4534, 4548, 4572, 4585, 4640, 4645, 4662, 4682, 4697, 4743, 4761, 4772, 4779, 4815, 4840, 4851, 4868, 4903, 4918, 4946, 4993, 5152, 5160, 5173, 5176, 5264, 5267], 'β-': [15, 197], 'and': [16, 49, 90, 93, 121, 142, 168, 198, 231, 272, 275, 303, 324, 350, 410, 640, 699, 702, 876, 933, 974, 1048, 1111, 1213, 1276, 1473, 1591, 1598, 1604, 1629, 1657, 1667, 1695, 1726, 1739, 1747, 1763, 1771, 1805, 1820, 1837, 1954, 1969, 1991, 2004, 2021, 2061, 2106, 2115, 2123, 2139, 2207, 2212, 2321, 2479, 2499, 2538, 2559, 2623, 2744, 2764, 2802, 2847, 2849, 2863, 2933, 2976, 2987, 3001, 3066, 3080, 3121, 3125, 3145, 3171, 3213, 3237, 3276, 3316, 3332, 3346, 3361, 3433, 3483, 3673, 3676, 3728, 3746, 3768, 3776, 3821, 3838, 3843, 3896, 3920, 3972, 3996, 4004, 4057, 4087, 4334, 4375, 4408, 4476, 4491, 4541, 4638, 4666, 4673, 4678, 4699, 4756, 4775, 4798, 4813, 4829, 4926, 5145, 5148, 5162, 5180, 5182, 5242, 5256, 5260], 'γ-secretases': [17, 199], 'to': [18, 42, 47, 55, 125, 131, 149, 200, 224, 229, 237, 307, 313, 331, 643, 663, 705, 711, 756, 773, 1054, 1431, 1439, 1570, 1579, 1601, 1611, 1636, 1653, 1949, 2072, 2099, 2184, 2204, 2238, 2247, 2677, 2692, 2727, 2899, 2961, 3015, 3062, 3074, 3155, 3177, 3205, 3301, 3322, 3342, 3411, 3418, 3451, 3479, 3629, 3732, 3788, 3803, 3855, 3901, 3913, 3967, 3976, 3989, 4069, 4090, 4098, 4108, 4127, 4142, 4207, 4210, 4216, 4227, 4260, 4288, 4292, 4338, 4359, 4362, 4369, 4381, 4392, 4419, 4560, 4595, 4745, 4768, 4911, 5171, 5183, 5274], 'produce': [19, 201, 1950, 3128], 'Aβ': [20, 202, 371, 377, 621, 623], 'as': [21, 23, 203, 205, 893, 1857, 2808, 3117, 4424, 4503, 4505, 4658, 4714], 'well': [22, 204, 4504], 'AID': [24, 38, 206, 220, 687, 769, 3058, 3179, 4264, 4275, 4374, 4407, 4429, 4793, 4866], '(APP': [25, 207], 'Intracellular': [26, 208], 'Domain)': [27, 209], 'which': [28, 210, 584, 611, 1349, 2856, 3693, 4531], 'derived': [30, 212, 4820], 'from': [31, 173, 213, 355, 658, 754, 1582, 1648, 1662, 1906, 1927, 2056, 2070, 2080, 2088, 2447, 2681, 2843, 3225, 3245, 3671, 3742, 4016, 4145, 4164, 4178, 4204, 4304, 4853], 'extreme': [33, 108, 215, 290], 'carboxyl': [34, 216, 665, 1621, 1675, 3107, 3817, 4329], 'terminus': [35, 217, 666], 'of': [36, 83, 163, 177, 218, 265, 345, 359, 404, 628, 636, 649, 667, 676, 695, 879, 1099, 1116, 1211, 1317, 1330, 1341, 1423, 1434, 1538, 1573, 1595, 1624, 1677, 1866, 1919, 1967, 2126, 2317, 2440, 2485, 2491, 2497, 2502, 2516, 2522, 2528, 2532, 2541, 2581, 2585, 2590, 2603, 2616, 2635, 2643, 2701, 2710, 2721, 2751, 2774, 2778, 2789, 2871, 2905, 2959, 2995, 3009, 3028, 3092, 3109, 3149, 3211, 3232, 3234, 3256, 3307, 3313, 3358, 3400, 3420, 3428, 3466, 3624, 3696, 3726, 3735, 3774, 3819, 3871, 3881, 3993, 4049, 4073, 4103, 4110, 4169, 4252, 4331, 4345, 4372, 4395, 4415, 4461, 4482, 4486, 4498, 4518, 4527, 4589, 4644, 4765, 4865, 4870, 4906, 4931, 4940, 4996, 5155, 5164, 5175, 5178, 5266, 5281], 'APP.': [37, 219, 926, 1583], 'was': [39, 221, 679, 689, 703, 1869, 1903, 1925, 1939, 2054, 2078, 2312, 2435, 2563, 2757, 2842, 2868, 2940, 2963, 2968, 3023, 3299, 3416, 4106, 4224, 4258, 4307, 4417], 'originally': [40, 222], 'shown': [41, 54, 223, 236, 704, 1610, 3478, 3628, 4427], 'lower': [43, 225, 4468], 'cellular': [45, 227], 'threshold': [46, 228], 'apoptosis': [48, 230, 712], 'more': [50, 232, 1562, 2176], 'recently': [51, 233, 768, 4597], 'has': [52, 133, 234, 315, 518, 525, 770, 1016, 1104, 1326, 3476, 3626, 4425], 'been': [53, 134, 147, 235, 316, 329, 519, 526, 771, 1010, 1017, 1105, 1217, 3477, 3627, 4426], 'modulate': [56, 238, 4363], 'expression': [58, 65, 240, 247, 871, 1433, 1938], 'such': [59, 241, 2955, 4941], 'that': [60, 78, 139, 242, 260, 321, 891, 1088, 1530, 1553, 1576, 1589, 1619, 1643, 2657, 2956, 3115, 3131, 3143, 3157, 3221, 3252, 3303, 3330, 3387, 3440, 3453, 3543, 3719, 3760, 3832, 3868, 4001, 4100, 4109, 4117, 4135, 4171, 4200, 4222, 4248, 4273, 4300, 4405, 4457, 4515, 4547, 4571, 4596, 4636, 4671, 4689, 4712, 4782, 4902, 4914, 4923], 'it': [61, 71, 243, 253, 524, 678, 1152, 4335, 4568], 'represses': [62, 244], 'Notch-dependent': [63, 245], 'while': [66, 248], 'in': [67, 101, 158, 169, 179, 249, 283, 340, 351, 361, 529, 633, 692, 775, 872, 1019, 1093, 1107, 1112, 1155, 1219, 1426, 1556, 1632, 1915, 2217, 2467, 2470, 2664, 2786, 3087, 3222, 3242, 3265, 3319, 3353, 3388, 3782, 3859, 4008, 4255, 4342, 4458, 4479, 4496, 4580, 4584, 4681, 4705, 4848, 4867], 'combination': [68, 250, 873, 1633], 'with': [69, 251, 638, 697, 874, 1470, 1634, 1679, 1710, 1859, 2038, 2162, 2222, 2463, 2598, 2600, 2629, 2688, 2717, 2747, 2858, 2911, 2930, 2945, 2970, 3005, 3033, 3363, 3375, 3380, 3404, 3432, 3464, 3632, 3778, 3823, 3911, 4013, 4043, 4079, 4197, 4213, 4233, 4240, 4309, 4316, 4325, 4354, 4992], 'Fe65': [70, 252, 875, 1628, 1635, 1647, 2068, 2599, 2630, 2670, 2675, 2738, 3406, 3567, 3625, 3850, 3875, 3912, 4144, 4163, 4203, 4223, 4253, 4261, 4326, 4356, 4416, 4677, 4680], 'enhances': [72, 254], 'activation.': [74, 256, 2605, 3326, 3355, 3556, 3687, 3712], 'Here': [75, 257], 'we': [76, 258, 1568, 1587, 1641, 3060, 3158, 3328, 3340, 3662, 3717, 3770, 3861, 4075, 4183, 4201, 4282, 4378, 4398, 4634, 5251, 5262], 'report': [77, 259, 1586, 3273, 4633], 'two': [80, 262, 568, 936, 3389, 4581, 4642], 'other': [81, 263, 937, 4641], 'members': [82, 167, 264, 349, 1356, 1543, 2862, 3255, 3396, 3636, 4643, 4844, 5265], 'APP': [85, 141, 165, 178, 267, 323, 347, 360, 365, 384, 522, 562, 571, 598, 938, 1336, 1472, 1477, 1541, 1566, 1868, 2702, 2839, 2860, 3051, 3118, 3258, 3394, 3546, 3634, 3909, 4500, 4646, 4715, 4766, 4773, 4842], 'family,': [86, 268, 1567, 4648], 'precursor-like': [88, 270, 378], 'protein-1': [89, 271], '-2': [91, 273], '(APLP1': [92, 274], 'APLP2),': [94, 276], 'are': [95, 123, 277, 305, 1300, 1320, 1350, 1428, 1475, 1533, 1577, 1593, 1599, 2661, 3147, 3169, 3260, 3730, 3974, 4006, 4120, 4140, 4154, 4649, 4915], 'also': [96, 278, 670, 1086, 1150, 1216, 1301, 1548, 1609, 2735, 3068, 3127, 3334, 3349, 3683, 4067, 4513, 4669], 'γ-secretase': [100, 282, 590, 617, 660, 673, 1597, 1654, 3094, 3135, 3209, 3264, 3305, 3435, 3448, 3486, 3702, 4294, 4346, 4349, 4462, 4483, 4694, 4744, 4997, 5157], 'a': [102, 284, 580, 592, 607, 2315, 2438, 2482, 2573, 2784, 2869, 3026, 3040, 3173, 3266, 3291, 3309, 3351, 3376, 3429, 3665, 3792, 3891, 3999, 4185, 4652, 4747, 4830, 4858], 'Presenilin': [103, 285, 1613], '1-dependent': [104, 286], 'manner.': [105, 287, 3269, 4708], 'Furthermore,': [106, 288, 1467, 3450, 4478], 'carboxyl-terminal': [109, 291, 2866], 'fragments': [110, 292, 1210, 1623, 3336, 4385, 4423], 'produced': [111, 293, 671], 'this': [113, 154, 295, 336, 1585, 3208, 3414, 3689, 3857, 4487, 4632, 4854], 'processing': [114, 296, 566, 1092, 1607, 3075, 3210, 3239, 3455, 4269, 5223], '(here': [115, 297], 'termed': [116, 298, 595, 655], 'APP-likeIntracellular': [117, 299], 'Domain': [118, 300], 'or': [119, 301, 683, 708, 1344, 1480, 1580, 1708, 2619, 2704, 2716, 2769, 3090, 3098, 3112, 3381, 4085, 4193, 4236, 4265, 4276, 4312, 4935], 'ALID1': [120, 302, 1603, 1976, 4475, 4665], 'ALID2)': [122, 304], 'able': [124, 306, 3975, 4068, 4141], 'enhance': [126, 308], 'Fe65-dependent': [127, 309, 4707], 'activation,': [129, 311, 3907], 'similar': [130, 312, 1578, 3176, 3430, 3666, 4107, 4126, 4186], 'what': [132, 314], 'reported': [135, 317], 'for': [136, 318, 1012, 1352, 1536, 1821, 1961, 2005, 2175, 2191, 2565, 2917, 3105, 3544, 3601, 3710, 3794, 4062, 4428, 4562, 4659, 4792, 4814, 4839, 4945, 5159, 5245, 5257, 5278], 'AID.': [137, 319], 'Considering': [138, 320], 'only': [140, 322, 2739, 3559, 4136, 4533], 'not': [143, 325, 1945, 2745, 3160, 3241, 4161, 4239, 4244, 4315], 'APLPs': [145, 327, 1090, 1575, 1626, 1645, 3767, 4119, 4174, 4333, 4573], 'have': [146, 328, 886, 1009, 1215, 3172, 3350], 'linked': [148, 330], '(AD),': [153, 335], 'data': [155, 337, 885, 3250, 3889, 4015, 4321, 4687, 4710], 'should': [156, 338, 3704, 4909], 'help': [157, 339], 'understanding': [159, 341], 'physiologic': [161, 343, 4860], 'roles': [162, 344, 1535], 'family': [166, 348, 402, 406, 517, 939, 1337, 1355, 1542, 2861, 3259, 3395, 3547, 3635, 4774, 4843], 'differentiating': [170, 352], 'these': [171, 353, 1013, 1318, 3795, 3888, 4383, 4396, 4590], 'functions': [172, 354, 1008], 'pathologic': [175, 357], 'role': [176, 358, 3352, 4791], 'disease.': [181, 363, 651], '1The': [366], 'abbreviations': [367], 'used': [368, 1744, 2313, 2436, 2564, 3024, 3300, 4060, 4088, 4215, 4399, 4418], 'are:': [369], 'APP,': [370, 408, 668, 1342, 2617, 3110, 3235, 3308, 3359, 3558, 3836, 4191, 4234, 4310, 4579, 4660], 'protein;': [373, 379, 397], 'Aβ,': [374], 'β-amyloid;': [375], 'APLP,': [376], 'AD,': [380], 'disease;': [382], 'AID,': [383, 656, 3314, 4924], 'intracellular': [385, 389, 4663, 4750], 'domain;': [386, 390], 'ALID,': [387], 'APP-like': [388], 'GST,': [391], 'glutathione': [392], 'S-transferase;': [393], 'YFP,': [394], 'yellow': [395], 'fluorescent': [396, 1956], 'PS,': [398], 'Presenilin;': [399], 'DAPI,': [400], '4′,6-diamidino-2-phenylindole': [401], 'consists': [403], 'three': [405, 3254, 4841], 'members,': [407, 3548], 'APLP1,': [409, 1343, 2618, 3111, 3236, 3360, 3837, 3842, 4082, 4192, 4235, 4311], 'APLP2': [411, 975, 1050, 1149, 1214, 1277, 1345, 1479, 1483, 1592, 1822, 1923, 1970, 2620, 2850, 2988, 3002, 3067, 3113, 3126, 3146, 3214, 3238, 3333, 3347, 3362, 3674, 3729, 3822, 3839, 3844, 3973, 4005, 4058, 4194, 4237, 4313, 4674, 5181, 5222], '(1Wasco,': [412], 'W.,': [413], 'Bupp,': [414], 'K.,': [415, 1024], 'Magendantz,': [416], 'M.,': [417, 471], 'Gusella,': [418], 'J.': [419, 456, 731, 902, 955, 988, 990, 1139, 1175, 1193, 1234, 1266, 1281, 1292, 1389, 1393, 1414, 1448, 1494, 1498, 1519, 1890, 2083, 2296, 2368, 2425, 2823, 3192, 3523, 3582, 3653, 3948, 4438, 4615, 4723, 4958, 4962, 4983, 5067, 5093, 5094, 5114, 5136, 5234], 'F.,': [420], 'Tanzi,': [421], 'R.': [422, 496, 791, 1059, 2295, 2814, 3645, 3943, 5025], 'E.': [423, 1171, 2342], '&': [424], 'Solomon,': [425], 'F.': [426, 750, 2262, 3571, 5197, 5205], 'Proc.': [427, 808, 827], 'Natl.': [428, 809, 828], 'Acad.': [429, 810, 829], 'Sci.': [430, 811, 830], 'U.': [431, 444, 812, 831, 951, 1127, 1413, 1444, 1518, 4982], 'S.': [432, 442, 469, 813, 832, 1125, 1283, 1387, 1405, 1492, 1510, 2090, 2091, 2384, 4956, 4974, 5120, 5128, 5239, 5240], 'A.,': [433, 745], '89,': [434], '10758–10762.Google': [435], 'Scholar,': [436, 465, 492, 547, 741, 789, 822, 841, 1184, 1385, 3508, 3934, 5052], '2Paliga': [437], 'K.': [438, 452, 500, 963, 1069, 1121, 1135, 1231, 1456, 3186, 4612, 5011], 'Peraus': [439, 1122], 'G': [440, 1123], 'Kreger': [441, 1124], 'Durrwang': [443, 1126], 'Hesse': [445, 1128], 'L.': [446, 716, 730, 743, 807, 1129, 1875, 1889, 2822, 5064, 5124], 'Multhaup': [447, 501, 1130], 'G.': [448, 502, 724, 1028, 1131, 1188, 1367, 1883, 3520, 3575, 3647, 3936, 4030, 5043, 5116], 'Masters': [449, 497, 1072, 1132], 'C.L.': [450, 498, 1073, 1133], 'Beyreuther': [451, 499, 1068, 1134], 'Weidemann': [453, 1136], 'A.': [454, 814, 833, 959, 961, 1067, 1137, 1259, 1395, 1452, 1454, 1500, 3579, 3643, 3941, 4964, 5023, 5118, 5195], 'Eur.': [455, 1138], 'Biochem.': [457, 1140, 3652], '1997;': [458, 1141, 1378], '250:': [459, 1142], '354-363Crossref': [460, 1143], 'PubMed': [461, 488, 508, 543, 557, 737, 785, 818, 837, 863, 916, 969, 999, 1043, 1079, 1144, 1182, 1204, 1245, 1271, 1297, 1381, 1419, 1462, 1524, 1757, 1896, 2307, 2430, 2834, 3197, 3286, 3504, 3534, 3593, 3613, 3657, 3930, 3959, 4038, 4449, 4626, 4737, 4808, 4896, 4988, 5030, 5048, 5078, 5105, 5140, 5214], 'Scopus': [462, 489, 509, 544, 558, 738, 786, 819, 838, 864, 917, 970, 1000, 1044, 1080, 1145, 1205, 1246, 1272, 1382, 1463, 1758, 1897, 2308, 2431, 2835, 3198, 3287, 3505, 3535, 3594, 3614, 3658, 3931, 3960, 4039, 4450, 4627, 4738, 4809, 4897, 5031, 5049, 5079, 5106, 5141, 5215], '(49)': [463, 1146], 'Google': [464, 491, 511, 546, 560, 740, 788, 821, 840, 866, 919, 972, 1002, 1046, 1082, 1147, 1183, 1207, 1248, 1274, 1298, 1384, 1420, 1465, 1525, 1760, 1899, 2310, 2433, 2837, 3200, 3289, 3507, 3537, 3596, 3616, 3660, 3933, 3962, 4041, 4452, 4629, 4740, 4811, 4899, 4989, 5033, 5051, 5081, 5108, 5143, 5217], '3Wasco': [466], 'W.': [467, 1032, 3188, 3491, 4026, 5005], 'Gurubhagavatula': [468], 'Paradis': [470], 'D.': [472, 1063, 1163, 1257, 2254, 2352, 5233], 'Romano': [473], 'D.M.': [474], 'Sisodia': [475, 1191, 1374, 1404, 1509, 2092, 3521, 4973], 'S.S.': [476, 533, 1061, 1192, 1375, 3522], 'Hyman': [477, 4031], 'B.T': [478], 'Neve': [479], 'R.L.': [480], 'Tanzi': [481, 1029, 4027], 'R.E.': [482, 1030, 2293, 4028], 'Nat.': [483, 537, 5208], 'Genet.': [484, 965, 1458], '1993;': [485], '5:': [486], '95-100Crossref': [487], '(322)': [490], '4Bayer': [493], 'T.A.': [494], 'Cappai': [495], 'Mol.': [503, 1037], 'Psychiatry.': [504], '1999;': [505, 554, 1076, 3501, 5027], '4:': [506], '524-528Crossref': [507], '(81)': [510], 'Scholar).': [512, 561, 766, 1003, 1083, 1148, 1208, 1249, 1421, 1466, 1526, 1761, 1900, 2838, 3201, 3538, 3617, 3963, 4453, 4630, 4990], 'Most': [513], 'research': [514, 4908], 'on': [515, 521, 947, 978, 1673, 2173, 2760, 3045, 3812, 3985, 4018, 4188], 'focused': [520], 'because': [523, 2668, 3167], 'directly': [527, 1905, 2137, 3631], 'implicated': [528, 1018], '(5Sisodia': [532], 'St': [534], 'George-Hyslop': [535], 'P.H.': [536], 'Rev.': [538], 'Neurosci.': [539, 1293, 1415, 1520, 4984], '2002;': [540, 815, 855, 1268, 2826, 4888, 5070, 5097, 5137], '3:': [541, 5212], '281-290Crossref': [542], '(487)': [545], '6Haass': [548], 'C.': [549, 718, 986, 1169, 1403, 1508, 1877, 4972, 5201], 'De': [550, 746, 2874, 3189, 5237], 'Strooper': [551, 747, 3190, 5002], 'B.': [552, 714, 748, 1873, 2289, 2340, 3191, 5003, 5236], 'Science.': [553, 781, 1753, 3282, 3609, 3926, 4804, 5044], '286:': [555], '916-919Crossref': [556], '(366)': [559], 'undergoes': [563, 895, 4716], 'extensive': [564, 5279], 'proteolytic': [565], 'along': [567, 2628, 4078, 4196, 4232, 4353], 'major': [569, 626, 646], 'pathways.': [570], 'can': [572, 599, 4357, 4675, 4700], 'be': [573, 600, 644, 1612, 3705, 4280, 4323, 4411, 4575, 4769, 4846, 4910, 5169], 'cleaved': [574, 587, 601, 614, 1302, 4650], 'extracellularly': [575, 602], 'α-secretase': [578], 'creating': [579], 'C83': [581, 3120], 'membrane-bound': [582, 609], 'intermediate,': [583, 610], 'subsequently': [586, 613], 'releasing': [591, 618, 3054], 'non-amyloidogenic': [593], 'fragment': [594, 1743, 3423, 3699], 'p3.': [596], 'Alternatively,': [597], 'β-secretase': [605], 'forming': [606], 'C99': [608, 3122], 'amyloidogenic': [620], 'fragment.': [622], 'component': [627], 'amyloid': [630], 'plaques': [631], 'found': [632, 772, 1011, 3329, 4221, 4767, 5189], 'brains': [635, 694, 1221], 'patients': [637, 696], 'AD': [639, 698], 'considered': [642], 'underlying': [647], 'cause': [648, 1346, 3323, 3397, 3684, 3733], 'An': [652], 'additional': [653], 'peptide': [654, 688, 3180], 'extending': [657], 'cleavage': [661, 674, 3306, 4565, 4591, 4695], 'site': [662, 5174], 'following': [672, 1787, 3304], 'regardless': [675], 'whether': [677, 3064, 3207, 3344, 3413, 3664, 3969, 4053, 4850, 5185], 'preceded': [680], 'α': [682], 'β': [684], 'cleavage.': [685], 'This': [686, 1606, 3141, 3473, 4320, 4655, 4758], 'first': [690, 2583, 2641, 2719, 2749, 2776, 3780, 3879, 3982, 4096, 4762], 'identified': [691, 1218, 2119], 'normal': [700], 'controls,': [701], 'either': [706, 2765, 3086, 4080], 'induce': [707], 'sensitize': [709], 'cells': [710, 1117, 2214, 2232, 2683, 3083, 3988], '(7Passer': [713, 1872], 'Pellegrini': [715, 1874], 'Russo': [717, 1876, 3580, 3650, 3946], 'Siegel': [719, 1878], 'R.M.': [720, 1879], 'Lenardo': [721, 1880], 'M.J.': [722, 1881, 4022], 'Schettini': [723, 1882], 'Bachmann': [725, 1884], 'M.': [726, 728, 953, 1365, 1446, 1885, 1887, 2358, 2820], 'Tabaton': [727, 1886], "D'Adamio": [729, 806, 1888, 2821, 5268], 'Alzheimers': [732, 1891], 'Dis.': [733, 1892], '2000;': [734, 908, 1416, 1521, 1893, 2299, 4729, 4985], '2:': [735, 1894], '289-301Crossref': [736, 1895], '(202)': [739, 1898], "8D'Adamio": [742], 'Israel': [744], 'Checler': [749, 5204], 'Christen': [751], 'Y.': [752, 824, 1223, 1233, 4604, 4614], 'Notch': [753, 894, 5000], 'Neurodevelopment': [755], 'Neurodegeneration:': [757], 'Keeping': [758], 'Fate.': [760], 'Fondation': [761], 'IPSEN,': [762], 'Springer,': [763], 'Berlin2002:': [764], '101-108Google': [765], 'More': [767], 'participate': [774], 'transcription': [776, 4704, 4930], '(9Cao': [777, 1749, 3278, 3605, 3922, 4800], 'X.': [778, 1750, 3279, 3606, 3923, 4801], 'Sudhof': [779, 1748, 1751, 3277, 3280, 3607, 3924, 4799, 4802], 'T.C.': [780, 1752, 2398, 3281, 3608, 3925, 4803], '2001;': [782, 834, 1179, 1237, 1294, 1754, 2427, 3194, 3283, 3526, 3610, 3927, 3951, 4441, 4618, 4805, 5045, 5211], '293:': [783, 1755, 3284, 3611, 3928, 4806], '115-120Crossref': [784, 1756, 3285, 3612, 3929, 4807], '(1054)': [787, 1759, 3288, 3615, 3932, 4810], '10Roncarati': [790], 'Sestan': [792], 'N.': [793, 1229, 3573, 3649, 3945, 4610], 'Scheinfeld': [794], 'M.H.': [795, 2394, 2812], 'Berechid': [796], 'B.E.': [797], 'Lopez': [798, 2817], 'P.A.': [799, 2374, 2412, 2818], 'McGlade': [800], 'J.C.': [801, 1285, 2400], 'Meucci': [802], 'O.': [803, 5203], 'Rakic': [804], 'P.': [805, 957, 1261, 1407, 1450, 1512, 2334, 2816, 3182, 3939, 4976, 5007, 5009, 5089, 5112, 5126], '99:': [816], '7102-7707Crossref': [817], '(181)': [820], '11Gao': [823], 'Pimplikar': [825], 'S.W.': [826], '98:': [835], '14979-14984Crossref': [836], '(210)': [839], '12Baek': [842], 'S.H.': [843, 1289, 3510, 4876], 'Ohgi': [844, 4877], 'K.A.': [845, 4878], 'Rose': [846, 4879], 'D.W.': [847, 1287, 2287, 4880], 'Koo': [848, 1262, 4881], 'E.H.': [849, 1263, 4882, 5015], 'Glass': [850, 4883], 'C.K.': [851, 4884], 'Rosenfeld': [852, 4885], 'M.G.': [853, 4886], 'Cell.': [854, 907, 4728, 4887], '110:': [856, 4889], '55-67Abstract': [857, 4890], 'Full': [858, 860, 911, 913, 1199, 1201, 1240, 1242, 2302, 2304, 2829, 2831, 3529, 3531, 3588, 3590, 3954, 3956, 4444, 4446, 4621, 4623, 4732, 4734, 4891, 4893, 5073, 5075, 5100, 5102], 'Text': [859, 861, 912, 914, 1200, 1202, 1241, 1243, 2303, 2305, 2830, 2832, 3530, 3532, 3589, 3591, 3955, 3957, 4445, 4447, 4622, 4624, 4733, 4735, 4892, 4894, 5074, 5076, 5101, 5103], 'PDF': [862, 915, 1203, 1244, 2306, 2833, 3533, 3592, 3958, 4448, 4625, 4736, 4895, 5077, 5104], '(495)': [865, 4898], 'Scholar)': [867, 920, 1275, 1299, 2311, 2434, 3597, 4042, 4741, 4812, 4900, 5218], 'activating': [869], 'repressing': [877], 'activation': [878, 2634, 2651, 2659, 2673, 3399, 3415, 3443, 3604, 3734, 3753, 3762, 3800, 3895], 'genes': [880, 4838, 4913, 4942], 'induced': [881], 'Notch.': [883], 'These': [884, 1527, 3249, 4709], 'opened': [887], 'important': [889, 3154], 'possibility': [890], 'just': [892, 3116, 4577, 4657, 4713], 'regulated': [896, 4717, 4916], 'intramembranous': [897, 4564, 4586, 4718], 'proteolysis': [898, 4719], '(13Brown': [899, 4720], 'M.S.,': [900, 4721], 'Ye,': [901, 4722], 'Rawson': [903, 4724], 'R.B.': [904, 4725], 'Goldstein': [905, 4726], 'J.L.': [906, 1026, 4727, 5207], '100:': [909, 4730], '391-398Abstract': [910, 4731], '(1149)': [918, 4739], 'γ-secretase,': [923, 3339], 'so': [924, 4272, 4752], 'does': [925], 'Much': [927], 'less': [928, 3852], 'known': [930], 'about': [931], 'APLP1': [932, 943, 1015, 1097, 1101, 1119, 1212, 1251, 1435, 1481, 1590, 1678, 1785, 1902, 1968, 2848, 2986, 3000, 3065, 3124, 3144, 3212, 3331, 3345, 3672, 3727, 3820, 3971, 3995, 4003, 4056, 4637, 4672, 4755, 5147, 5179, 5220], 'APLP2,': [934, 4083, 4639, 5149], 'members.': [940, 1338], 'human': [942, 1108], 'located': [946, 977, 4121], 'chromosome': [948, 979], '19q13.1': [949], '(14Lenkkeri': [950, 1443], 'Kestila': [952, 1445], 'Lamerdin': [954, 1447], 'McCready': [956, 1449], 'Adamson': [958, 1451], 'Olsen': [960, 1453], 'Tryggvason': [962, 1455], 'Hum.': [964, 1457], '1998;': [966, 1459, 3654, 4035], '102:': [967, 1460], '192-196Crossref': [968, 1461], '(18)': [971, 1464], 'Scholar),': [973, 1047, 3290, 3661, 5034, 5082, 5109, 5144], '11q23-q25': [980], '(15von': [981], 'der': [982, 1369], 'Kammer': [983], 'H.': [984, 1225, 1361, 1363, 1400, 1505, 4606, 4969], 'Loffler': [985], 'Hanes': [987], 'Klaudiny': [989], 'Scheit': [991], 'K.H.': [992], 'Hansmann': [993], 'I.': [994, 3184], 'Genomics.': [995], '1994;': [996], '20:': [997, 1417, 1522, 4986], '308-311Crossref': [998], '(22)': [1001], 'Although': [1004], 'no': [1005, 4274], 'clear': [1006], 'neuronal': [1007], 'molecules,': [1014], 'synaptogenesis': [1020], '(16Kim': [1021], 'T.W.,': [1022], 'Wu,': [1023, 2381], 'Xu,': [1025], 'McAuliffe': [1027], 'Wasco': [1031, 4025], 'Black': [1033], 'I.B.': [1034], 'Brain': [1035, 1038, 4033], 'Res.': [1036, 1039, 4034], '1995;': [1040, 1196, 3585], '32:': [1041], '36-44Crossref': [1042], '(61)': [1045], 'recombinant': [1049], 'possess': [1051], 'ability': [1053], 'promote': [1055], 'neurite': [1056], 'outgrowth': [1057], '(17Cappai': [1058], 'Mok': [1060], 'Galatis': [1062], 'Tucker': [1064], 'D.F.': [1065], 'Henry': [1066], 'Small': [1070], 'D.H.': [1071, 2260], 'FEBS': [1074], 'Lett.': [1075], '442:': [1077], '95-98Crossref': [1078], '(50)': [1081], 'There': [1084], 'evidence': [1087], 'undergo': [1091], 'ectodomain.': [1095], 'Secretory': [1096], 'consisting': [1098, 3312], 'extracellular': [1102, 1153], 'domain': [1103, 1154, 3370, 3623], 'detected': [1106, 2941, 2969, 2990, 3004], 'cerebrospinal': [1109], 'fluid': [1110], 'conditioned': [1114], 'media': [1115, 2245], 'overexpressing': [1118, 2684], '(2Paliga': [1120], 'sheds': [1151], 'multiple': [1156], 'cell': [1157, 2913, 3390], 'culture': [1158], 'systems': [1159], '(18Xu': [1160], 'K.P.': [1161, 2370], 'Zoukhri': [1162], 'Zieske': [1164], 'J.D.': [1165, 2256], 'Dartt': [1166], 'D.A.': [1167], 'Sergheraert': [1168], 'Loing': [1170], 'Yu': [1172], 'F.S.': [1173], 'Am.': [1174], 'Physiol.': [1176, 1178], 'Cell': [1177, 2799, 5209], '281:': [1180], 'C603-C614Crossref': [1181], '19Lo': [1185], 'A.C.': [1186], 'Thinakaran': [1187, 1366, 3519, 4029], 'Slunt': [1189, 3515], 'H.H.': [1190, 3516], 'Biol.': [1194, 1235, 2297, 2824, 3524, 3583, 3949, 4439, 4616, 5068, 5095, 5210], 'Chem.': [1195, 1236, 2298, 2825, 3525, 3584, 3950, 4440, 4617, 5069, 5096], '270:': [1197, 3586], '12641-12645Abstract': [1198], '(20)': [1206], 'Carboxyl-terminal': [1209], 'rat': [1220], '(20Gu': [1222, 4603], 'Misonou': [1224, 4605], 'Sato': [1226, 4607], 'T.': [1227, 1397, 1502, 2449, 3581, 3651, 3947, 4608, 4966, 5132, 5229, 5231, 5243, 5276], 'Dohmae': [1228, 4609], 'Takio': [1230, 4611], 'Ihara': [1232, 4613], '276:': [1238, 3527, 3952, 4442, 4619], '35235-35238Abstract': [1239, 4620], '(269)': [1247, 3595, 4628], 'Both': [1250], '(21Galvan': [1252], 'V.': [1253, 1391, 1496, 2326, 3577, 4960, 5017, 5122], 'Chen': [1254, 1362, 2329], 'S.,': [1255], 'Lu,': [1256], 'Logvinova': [1258], 'Goldsmith': [1260], 'Bredesen': [1264], 'D.E.': [1265], 'Neurochem.': [1267, 2426, 3193], '82:': [1269], '283-294Crossref': [1270], '(83)': [1273], '(22Cowan': [1278], 'C.M.': [1279, 2258], 'Thai': [1280], 'Krajewski': [1282], 'Reed': [1284], 'Nicholson': [1286], 'Kaufmann': [1288], 'Roskams': [1290], 'A.J.': [1291], '21:': [1295, 5138], '7099-7109Crossref': [1296], 'caspases': [1304], 'within': [1305], 'their': [1306, 2596, 3740], 'cytoplasmic': [1307, 1770, 3369], 'domains': [1308, 1773], 'at': [1309, 2194, 2197, 2209, 2314, 2437, 2920, 3025, 4046], 'conserved': [1311, 2587, 2645, 2723, 2780, 3639, 3784, 4770], 'VEVD': [1312], 'motif.': [1313], 'Still,': [1314, 4391], 'significance': [1316], 'cleavages': [1319], 'unknown.': [1321], 'Work': [1322], 'using': [1323, 2047, 2457, 2551, 2572, 2886, 2895, 2952, 2991, 3039, 3102, 4821], 'knockout': [1324, 1485, 1558, 2108, 3227], 'mice': [1325, 1469, 1486, 2086, 2096, 3228], 'revealed': [1327, 3437], 'an': [1328, 2992, 3006, 3046, 3405, 3421, 4466, 4494, 4563, 4706, 4822, 4871, 5186], 'aspect': [1329, 4764], 'relationships': [1332], 'between': [1333, 3765, 3893, 3917], 'various': [1335], 'Single': [1339], 'disruptions': [1340], 'minor': [1347], 'abnormalities,': [1348], 'distinct': [1351, 4582, 4936], 'different': [1354, 1540, 1581, 4177, 4947], '(23von': [1357], 'Koch': [1358, 1402, 1507, 4971], 'C.S.': [1359], 'Zheng': [1360, 4432], 'Trumbauer': [1364], 'van': [1368], 'Ploeg': [1370], 'L.H.': [1371, 2356], 'Price': [1372], 'D.L.': [1373, 2402], 'Neurobiol.': [1376], 'Aging.': [1377], '18:': [1379], '661-669Crossref': [1380], '(287)': [1383], '24Heber': [1386], 'Herms': [1388, 1493, 4957], 'Gajic': [1390, 1495, 4959], 'Hainfellner': [1392, 1497, 4961], 'Aguzzi': [1394, 1499, 4963], 'Rulicke': [1396, 1501, 4965], 'von': [1398, 1401, 1503, 1506, 4967, 4970], 'Kretzschmar': [1399, 1504, 4968], 'Tremml': [1406, 1511, 4975], 'Lipp': [1408, 1513, 4977], 'H.P.': [1409, 1514, 4978], 'Wolfer': [1410, 1515, 4979], 'D.P.': [1411, 1516, 4980], 'Muller': [1412, 1517, 4981], '7951-7963Crossref': [1418, 1523, 4987], 'Some': [1422], 'differences': [1425], 'phenotype': [1427], 'probably': [1429, 4352, 4367], 'related': [1430], 'being': [1436, 4336], 'restricted': [1437], 'mostly': [1438, 4156, 4226], 'nervous': [1441], 'system': [1442, 2889, 3298, 4824, 4856], 'although': [1468, 1531, 3833, 4152], 'both': [1471, 1959, 2444, 3720, 4002], 'APLP1-disrupted': [1474], 'normal,': [1476], 'plus': [1478, 1482], 'double': [1484], 'die': [1487], 'soon': [1488], 'after': [1489, 2548, 4693], 'birth': [1490], '(24Heber': [1491, 4955], 'observations': [1528], 'indicate': [1529, 3251, 4711], 'there': [1532, 1546, 2631, 3229, 4464, 4492, 5150], 'unique': [1534], 'each': [1537], 'during': [1544, 4786], 'development,': [1545], 'functional': [1549, 4763, 4780], 'redundancy': [1550, 4781], 'among': [1551, 4784], 'them': [1552, 2237, 4785], 'allows': [1554], 'compensation': [1555], 'single': [1557], 'mice.': [1559], 'To': [1560, 3757, 4051, 4267], 'gain': [1561], 'insight': [1563], 'into': [1564, 1780, 1862, 1935, 2041, 3367, 4166], 'sought': [1569, 3061, 3341], 'identify': [1571], 'aspects': [1572], 'In': [1584, 3270, 3713, 3899, 4631, 4684], 'show': [1588, 1618, 1642, 3302, 3718, 3759, 3890, 4635, 4670], 'substrates': [1594, 3148, 4998], 'release': [1602, 3069, 3335, 3419, 4746], 'ALID2.': [1605, 4477, 4667], '1': [1614, 2153, 2159, 2918, 3219], '(PS1)-dependent.': [1615], 'We': [1616, 3202, 3408, 3805, 3964, 3981, 4095, 4220, 4246, 4668, 5225, 5270], 'further': [1617, 3758, 4133], 'terminal': [1622, 1676, 1963, 2612, 2697, 2706, 3561, 3722, 4330, 4535], 'bind': [1627, 3630, 3840, 4676], 'may': [1630, 3348, 4574, 4593, 4776, 4928, 4943], 'function': [1631], 'activate': [1637, 4702, 4929], 'expression.': [1639, 4365], 'Finally,': [1640, 4366, 4991], 'full-length': [1644, 1867, 1924, 3743, 3908, 3970, 4055, 4138, 4402], 'restrict': [1646], 'entering': [1649], 'nucleus': [1651, 3321, 3919, 4125, 4257, 4306, 4361, 4698], 'prior': [1652], 'processing.': [1655, 4295, 4347], 'Gal4-APP': [1656], 'Gal4-APPCT44': [1658], 'constructs': [1659, 1948, 1958, 2045, 3357, 3744, 4059, 4403], 'were': [1660, 1669, 1765, 1789, 1853, 1971, 2034, 2049, 2063, 2093, 2097, 2113, 2118, 2135, 2171, 2188, 2202, 2215, 2233, 2445, 2455, 2508, 2543, 2546, 2570, 2686, 2805, 2852, 2879, 2893, 2909, 2928, 2950, 2989, 3003, 3031, 3037, 3084, 3373, 3461, 4066, 4379], 'obtained': [1661, 2046, 2055, 2079, 2087, 2446, 4308], 'Dr.': [1663, 2057, 2081, 2089, 2448, 2872, 5275], 'Thomas': [1664], 'Sudhof.': [1665], 'Gal4-APLP1CT44': [1666], 'Gal4-APLP2CT44': [1668], 'made': [1670, 1854, 2035], 'PCR': [1672, 1779, 1856, 2037, 2048], 'primers': [1680, 1711, 1788], 'sense:': [1681, 1712, 1823, 1977, 2007], '5′-AAG': [1682, 1713], 'GGG': [1683, 1691, 1714, 1797, 1996], 'ATC': [1684, 1693, 1715, 1723, 1733, 1735, 1848, 1984, 2014, 2016, 2027, 2029], 'CCA': [1685, 1716, 2000], 'CCG': [1686, 1717, 1994], 'GGA': [1687, 1718, 2001], 'AAG': [1688, 1707], 'CCC': [1689, 1801], 'TAC': [1690], 'GCT': [1692, 1794, 1809, 1826, 1841], 'AGC-3′': [1694], 'antisense:': [1696, 1727, 1806, 1838, 1992, 2022], '5′-TCG': [1697, 1728], 'CAG': [1698, 1701, 1719, 1729, 1800], 'TCG': [1699, 1730], 'ACT': [1700], 'GGT-3′': [1702], '5′-CGT': [1703], 'TCC': [1704, 1705, 1737, 1987, 2031], 'AGG': [1706, 1815, 1850], 'APLP2-3′': [1709], 'TAT': [1720], 'GGC': [1721, 1811, 1829, 1830, 1835, 1843], 'ACC': [1722, 1731, 1849, 2024], 'AGC': [1724, 1795, 1810, 1816, 1817, 1827, 1842, 1847, 2002, 2017], 'CAC-3′': [1725], 'TAA': [1732], 'TGC': [1734, 1736, 1803, 2028, 2030], 'AG-3′': [1738], 'replacing': [1740], 'APPCT44': [1742], 'Cao': [1746, 3275, 4797], 'Gal4-APLP1': [1762], 'Gal4-APLP2': [1764], 'constructed': [1766, 2064], 'adding': [1768], 'transmembrane': [1772], 'before': [1774], 'Gal4': [1776, 2505, 2535], 'tag': [1777, 1910, 1930], 'NheI': [1782], 'site.': [1783, 4566], 'For': [1784, 1975, 2451, 2472, 2510, 3557, 5248], 'used.': [1790, 2094, 2509, 2544], 'Sense:': [1791], '5′-TTT': [1792, 1807, 1824, 1839, 2023], 'TTT': [1793, 1808, 1825, 1840], 'GAT': [1796, 1828], 'GCC': [1798, 1981, 1982, 2011, 2012], 'CGC': [1799, 1802, 1814, 1834], 'TC-3′': [1804], 'TTC': [1812, 1845], 'CTG': [1813, 1989, 2018], 'ATG': [1818, 1983, 1988, 2013], 'GAG-3′': [1819], 'CAC': [1831], 'CGG': [1832], 'GAC': [1833], 'CG-3′': [1836], 'CTC': [1844, 1846, 1979, 1986, 2009], 'CTG-3′.': [1851], 'Mutants': [1852, 2033], 'above': [1858, 4061], 'mutations': [1860, 2039], 'incorporated': [1861], 'primers.': [1864, 2043], 'Cloning': [1865], 'described': [1870, 2809, 4795, 4817, 4950], 'previously': [1871, 2810, 4794], 'Full-length': [1901, 3356], 'expressed': [1904, 1908, 1928, 2880, 4076, 4195, 4231], 'sequence': [1909, 1929, 3708], 'I.M.A.G.E.': [1911, 1931], 'Clone': [1912, 1932], 'ID:': [1913, 1933], '4180020': [1914], 'pCMV-SPORT6': [1916], '(under': [1917], 'control': [1918], 'cytomegalovirus': [1921], 'promoter).': [1922], 'cloned': [1926], '2820109': [1934], 'pcDNA3.': [1936], 'Robust': [1937], 'confirmed': [1940, 2050], 'Western': [1942, 2803, 2943, 3100, 4387], 'blotting': [1943, 2804, 2944, 3101, 4388], '(data': [1944, 4243], 'shown).': [1946, 4245], 'pGEX5–1': [1947], 'GST': [1951, 2693, 2906, 3808], 'fusion': [1952, 2506, 2536, 2907, 3295, 3813], 'proteins': [1953, 2507, 2743, 2746, 2878, 2908, 3814, 4139, 4828], 'cyan': [1955], 'protein-tagged': [1957], 'coding': [1960], '57': [1964, 2698, 2707], 'amino': [1965, 2614, 2699, 2708, 3563, 3668, 3724, 4537, 4555], 'acids': [1966, 2615, 2700, 2709, 3564, 3725, 4538], 'generated': [1972], 'PCR.': [1974], '5′-AAA': [1978, 2008], 'GAG': [1980, 2010], 'GTC': [1985, 1995, 1997, 2015], 'CTC-3′': [1990], '5′-TTA': [1993], 'GTT': [1998], 'CCT': [1999], 'G-3′,': [2003], 'ALID2': [2006, 4927], 'GTG': [2019], 'ATG-3′': [2020], 'GGT': [2025], 'CGA': [2026], 'AGG-3′.': [2032], 'introduced': [2040], 'All': [2044], 'sequencing.': [2052], 'YFP-Fe65': [2053, 2071, 4077], 'Tommaso': [2058], 'Russo.': [2059], 'FLAG-Fe65': [2060, 2685, 2763, 2916], 'GFP-Fe65': [2062], 'moving': [2066, 4165], 'insert': [2069], 'appropriate': [2074], 'vectors.': [2075], 'PS1': [2076, 2101, 2107, 2865, 3226, 3470, 3550], 'D385A': [2077, 3551], 'Dennis': [2082], 'Selkoe.': [2084], 'PS1+/−': [2085, 2095], 'intercrossed': [2098], 'obtain': [2100], 'wild': [2102, 2609, 2712, 2741, 2766, 2998, 3246, 3834, 4180, 4189], 'type': [2103, 2610, 2713, 2742, 2767, 2999, 3247, 3835, 4181, 4190], '(PS1+/+,': [2104], 'PS1+/−)': [2105], 'pups.': [2109], 'E17.5–18.5': [2110], 'pregnant': [2111], 'females': [2112], 'sacrificed,': [2114], 'PS1−/−': [2116], 'pups': [2117], 'skeletal': [2121], 'defects': [2122], 'presence': [2125, 3091, 4481], 'cerebral': [2127], 'hemorrhages.': [2128], 'Fetal': [2129], 'tissues': [2130], '(from': [2131], '2–3': [2132], 'embryos': [2133], 'pooled)': [2134], 'harvested': [2136], 'into,': [2138], 'then': [2140, 2189, 3806], 'homogenized': [2141], 'in,': [2142], 'lysis': [2143, 2553], 'buffer': [2144, 2555, 2932], '(20': [2145], 'mm': [2146, 2151, 2154, 2160], 'Tris,': [2147], 'pH': [2148], '7.5,': [2149], '150': [2150], 'NaCl,': [2152], 'EDTA,': [2155], '1%': [2156], 'Nonidet': [2157], 'P-40,': [2158], 'Na3VO4)': [2161], 'protease': [2163], 'inhibitors': [2164, 3095, 3436, 4463, 5158], '(Roche': [2165, 2460], 'Molecular': [2166, 2461], 'Biochemicals': [2167], 'complete': [2168, 4302], 'tablets).': [2169], 'Samples': [2170], 'incubated': [2172, 2687, 2910, 3085], 'ice': [2174], 'than': [2177, 2663, 2674, 4524, 4553], '30': [2178], 'min,': [2179], 'inverting': [2180], 'every': [2181], '10': [2182], 'min': [2183, 2193], 'mix.': [2185], 'samples': [2187, 2465], 'spun': [2190], '5': [2192, 4455, 4512], '12,000': [2195], 'rpm': [2196], '4': [2198, 4114, 4131, 4297], '°C.': [2199], 'supernatants': [2201], 'transferred': [2203], 'fresh': [2205], 'tubes': [2206], 'stored': [2208], '−80.': [2210], 'HEK293T': [2211], 'N2a': [2213, 2231, 3081, 3987], 'grown': [2216], 'RPMI': [2218], '1640': [2219], 'medium': [2220, 4291], '(Invitrogen)': [2221], '10%': [2223], 'heat-inactivated': [2224], 'fetal': [2225], 'calf': [2226], 'serum': [2227], '(Biofluids;': [2228], 'Rockville,': [2229], 'MD).': [2230], 'differentiated': [2234, 3986], 'allowing': [2236], 'grow': [2239], '3': [2240, 2318, 2481, 3829, 3865], 'days': [2241], 'without': [2242, 3382, 3434], 'changing': [2243], 'leading': [2246], 'low': [2248, 5083], 'serum-induced': [2249], 'differentiation.': [2250], 'Compound': [2251, 3096], 'E': [2252, 3097], '(25Seiffert': [2253], 'Bradley': [2255], 'Rominger': [2257, 2259], 'Yang': [2261, 2383], 'Meredith': [2263], 'Jr.,': [2264], 'J.E.': [2265, 2354, 2424], 'Wang': [2266], 'Q.': [2267], 'Roach': [2268], 'A.H.': [2269], 'Thompson': [2270], 'L.A.': [2271], 'Spitz': [2272], 'S.M.': [2273], 'Higaki': [2274], 'J.N.': [2275], 'Prakash': [2276], 'S.R.': [2277], 'Combs': [2278], 'A.P.': [2279], 'Copeland': [2280], 'R.A.': [2281], 'Arneric': [2282], 'S.P.': [2283, 2418], 'Hartig': [2284], 'P.R.': [2285], 'Robertson': [2286], 'Cordell': [2288], 'Stern': [2290], 'A.M.': [2291], 'Olson': [2292], 'Zaczek': [2294], '275:': [2300], '34086-34091Abstract': [2301], '(303)': [2309], 'concentration': [2316, 2439], '×': [2319, 2442, 4285], '10−8m': [2320], 'DAPT': [2322, 4287], '(26Dovey': [2323], 'H.F.': [2324], 'John': [2325], 'Anderson': [2327], 'J.P.': [2328], 'L.Z.': [2330], 'de': [2331, 3937], 'Saint': [2332], 'Andrieu': [2333], 'Fang': [2335], 'L.Y.': [2336], 'Freedman': [2337], 'S.B.': [2338], 'Folmer': [2339], 'Goldbach': [2341], 'Holsztynska': [2343], 'E.J.,': [2344], 'Hu,': [2345], 'K.L.': [2346, 2348, 2372], 'Johnson-Wood': [2347], 'Kennedy': [2349], 'S.L.': [2350], 'Kholodenko': [2351], 'Knops': [2353], 'Latimer': [2355], 'Lee': [2357, 5061], 'Liao': [2359], 'Z.': [2360, 5130], 'Lieberburg': [2361], 'I.M.': [2362], 'Motter': [2363], 'R.N.': [2364], 'Mutter': [2365], 'L.C.': [2366], 'Nietz': [2367], 'Quinn': [2369], 'Sacchi': [2371], 'Seubert': [2373], 'Shopp': [2375], 'G.M.': [2376], 'Thorsett': [2377], 'E.D.': [2378], 'Tung': [2379], 'J.S.,': [2380], 'J.S.': [2382, 5013, 5062], 'Yin': [2385], 'C.T.': [2386, 4024], 'Schenk': [2387], 'D.B.': [2388], 'May': [2389], 'P.C.': [2390], 'Altstiel': [2391], 'L.D.': [2392], 'Bender': [2393], 'Boggs': [2395], 'L.N.': [2396], 'Britton': [2397], 'Clemens': [2399], 'Czilli': [2401], 'Dieckman-McGinty': [2403], 'D.K.': [2404], 'Droste': [2405], 'J.J.': [2406, 3514], 'Fuson': [2407], 'K.S.': [2408], 'Gitter': [2409], 'B.D.': [2410], 'Hyslop': [2411], 'Johnstone': [2413], 'E.M.,': [2414], 'Li,': [2415], 'W.Y.': [2416], 'Little': [2417], 'Mabry': [2419], 'T.E.': [2420, 5041], 'Miller': [2421], 'F.D.': [2422], 'Audia': [2423], '76:': [2428], '173-181Crossref': [2429], '(797)': [2432], '2': [2441, 2512, 2666, 3540, 3680, 3715, 3749, 3755, 4284], '10−6m,': [2443], 'Golde.': [2450], 'luciferase': [2452, 2486, 2517, 2560, 4064], 'assays,': [2453], 'transfections': [2454], 'done': [2456, 2466], 'FuGENE': [2458, 2953], '6': [2459, 2954], 'Biochemicals)': [2462], 'all': [2464, 2859, 3253, 3392, 3545, 3633], '96-well': [2468], 'plates': [2469], 'triplicate.': [2471], 'Fig.': [2473, 2480, 2511, 2665, 3218, 3539, 3679, 3714, 3748, 3828, 3864, 4113, 4130, 4296, 4454, 4511], '2,': [2474], 'b,': [2475, 2679], 'c,': [2476], 'e,': [2477], 'andf': [2478], '0.06': [2483, 2495, 2500], 'μg': [2484, 2490, 2496, 2501, 2515, 2521, 2527, 2531, 2540], 'reporter': [2487, 2518, 2552, 2637, 3297, 3324, 3378, 3402, 3441, 3458, 3554, 3602, 3685, 3737, 3798, 3905, 4832, 4855], 'plasmid,': [2488, 2519], '0.01': [2489, 2520], 'plasmid': [2492, 2523], 'encoding': [2493, 2504, 2524, 2534], 'β-galactosidase,': [2494, 2525], 'YFP-Fe65/YFP,': [2498], 'DNA': [2503, 2533], 'd': [2513, 3541], '0.03': [2514], '0.02': [2526], 'YFP-Fe65,': [2529], '0.04': [2530], 'proteins,': [2537, 4182], '0.1': [2539], 'PS/pcDNA3.1': [2542], 'Cells': [2545, 2949], 'lysed': [2547], '24–48': [2549], 'h': [2550, 2919], '5×': [2554], '(Promega,': [2556], 'Madison,': [2557], 'WI),': [2558], 'substrate': [2561], '(Promega)': [2562], 'assay.': [2567], 'Luciferase': [2568], 'values': [2569, 2660], 'normalized': [2571], 'β-galactosidase': [2574], 'assay': [2575, 3431], '(Tropix,': [2576], 'Bedford,': [2577], 'Massachusetts).Figure': [2578], '3Point': [2579], 'mutation': [2580, 3475, 3848], 'tyrosine': [2584, 2642, 2720, 2750, 2777, 3781, 3826, 3880], 'YENPTY': [2588, 2646, 2724, 2753, 2781, 3640, 3785, 3883], 'motif': [2589, 2647, 2725, 2754, 2782, 3569, 3641, 3786, 3884], 'ALIDs': [2592, 3072, 4409, 4816], 'abolish': [2593, 3484], 'nearly': [2594, 3802, 4270, 4301], 'completely': [2595, 2654], 'interaction': [2597, 3764, 3858], 'concomitant': [2601], 'abolishment': [2602], 'transcriptional': [2604, 3398, 3711, 4790], 'a,': [2606], 'when': [2607, 3133, 3877, 4230], '(wt)': [2611, 2768], '44': [2613, 3562, 3667, 3723, 4536, 4554], '(APPCT44,': [2621, 4539], 'APLP1CT44': [2622, 3775], 'APLP2CT44,': [2624, 3677], 'respectively)': [2625], 'co-expressed': [2627], 'strong': [2633], 'gene.': [2638, 4833], 'When': [2639], 'mutated': [2649, 2726, 3787], '(Y-G),': [2650], 'almost': [2653], 'abolished.': [2655], 'Note': [2656], 'greater': [2662, 2672], 'e': [2667, 3716], 'untagged': [2669, 4373], 'causes': [2671, 2783], 'fused': [2676], 'YFP.': [2678], 'lysates': [2680, 2761, 2914, 3224, 3244], '293': [2682, 2912], 'Sepharose': [2689], 'beads': [2690, 2897, 2927], 'bound': [2691, 4355], 'alone': [2694], '(−),': [2695], '(AID)': [2703], 'APLP1/2': [2711], '(ALID1/2': [2714, 2729], 'w.t.),': [2715], 'glycine': [2728], 'Y-G).': [2730], 'total': [2732], 'lysate': [2733], 'indicated': [2736], '(T.L.).': [2737], 'binds': [2740, 3849], 'mutated.c,': [2755], 'immunoprecipitation': [2756], 'carried': [2758, 2806, 3462], 'out': [2759, 2807, 3463], 'containing': [2762, 2915, 3565, 3815, 3845], 'mutant': [2770, 3471, 3552], '(Y-G)': [2771], 'ALIDs.': [2772, 4266, 4919], 'Mutation': [2773], 'decrease': [2785], 'amount': [2788, 3870, 4251], 'ALID': [2790, 3164, 3698, 3872, 4351, 4376, 4422, 4690], 'immunoprecipitated': [2791, 3873], 'Fe65.View': [2793], 'Large': [2794], 'Image': [2795], 'Figure': [2796], 'ViewerDownload': [2797], '(PPT)': [2798], 'lysis,': [2800], 'immunoprecipitation,': [2801], '(27Scheinfeld': [2811], 'Roncarati': [2813], 'Vito': [2815], 'Abdallah': [2819], '277:': [2827, 5071, 5098], '3767-3775Abstract': [2828], '(148)': [2836], 'specific': [2840, 3104], 'antibody': [2841, 2867, 2947, 2973, 2979, 2993, 3007, 3012], 'Zymed': [2844], 'Laboratories': [2845], 'Inc.,': [2846], 'antibodies': [2851, 3103], 'fromCalbiochem.': [2853], 'Antibody': [2854], 'B10,': [2855], 'cross-reacts': [2857], 'gift': [2870], 'Bart': [2873], 'Strooper.': [2875], 'Recombinant': [2876], 'GST-fusion': [2877], 'inEscherichia': [2881], 'coli': [2882], 'strain': [2883], 'BL21': [2884], '(Stratagene)': [2885], 'pGEX': [2888], '(Amersham': [2890], 'Biosciences).': [2891], 'Proteins': [2892], 'purified': [2894], 'glutathione-Sepharose': [2896], 'according': [2898], "manufacturer's": [2901], 'instructions.': [2902], 'Equal': [2903], 'amounts': [2904], 'room': [2921], 'temperature.': [2922], 'Following': [2923], 'five': [2924], 'washes': [2925], 'boiled': [2929], 'loading': [2931], 'separated': [2934], 'SDS-PAGE.': [2936], 'Pulled': [2937], 'down': [2938, 3810], 'anti-FLAG': [2946], '(Sigma).': [2948, 3035], 'transfected': [2951], 'ratio': [2958], 'APP/APLP1/APLP2': [2960], 'YFP/GFP-Fe65': [2962], '4:1.': [2964], 'Gal4BD': [2966, 3292, 3365, 4093], 'epitope': [2967], 'anti-Gal4BD': [2971], 'monoclonal': [2972], '(Santa': [2974], 'Cruz)': [2975], 'Cy5-conjugated': [2977], 'secondary': [2978], '(Jackson': [2980], 'ImmunoResearch,': [2981], 'West': [2982], 'Grove,': [2983], 'PA).': [2984], 'Endogenous': [2985], 'dilution': [2994, 3008, 3027], '1:2500.': [2996], 'Overexpressed': [2997], '1:10,000.': [3010], 'Secondary': [3011], 'Alexa-594': [3013, 4214], 'conjugated': [3014], 'goat': [3016], 'anti-rabbit': [3017], 'IgG': [3018], '(Molecular': [3019], 'Probes,': [3020], 'Eugene,': [3021], 'OR)': [3022], '1:250.': [3029], 'Nuclei': [3030], 'stained': [3032], 'DAPI': [3034], 'Images': [3036], 'captured': [3038], 'charge-coupled': [3041], 'device': [3042], 'camera': [3043], 'mounted': [3044], 'Olympus': [3047], 'Provis': [3048], 'AX70.': [3049], 'Since': [3050, 3618], 'signals': [3052], 'biologically': [3056, 3070, 4748], 'active': [3057, 3071, 3422, 4749], 'peptide,': [3059, 4751], 'investigate': [3063], 'due': [3073, 3417, 4259, 4368], 'γ-secretase.': [3078, 3151, 3426, 4654], 'HEK293': [3079], 'neuroblastoma': [3082], 'absence': [3089, 4344, 4460], 'DAPT.': [3099], 'termini': [3108, 3818], 'showed': [3114], 'produces': [3119], 'intermediates,': [3123], 'C83/C99-like': [3129], 'intermediates': [3130, 3233, 4501], 'accumulate': [3132], 'activity': [3136, 3487], 'inhibited': [3138, 3446], '(Fig.1': [3139], 'a).': [3140], 'suggested': [3142], 'It': [3152, 4920], 'note': [3156], 'did': [3159], 'detect': [3161, 4382, 4393], 'endogenous': [3163, 3481, 3994, 4111, 4128, 4384, 4836, 4872], 'peptides,': [3165, 4377], 'perhaps': [3166, 4557], 'they': [3168, 4153], 'unstable': [3170], 'short': [3174], 'half-life': [3175], '(28Cupers': [3181], 'Orlans': [3183], 'Craessaerts': [3185, 5010], 'Annaert': [3187, 5004], '78:': [3195], '1168-1178Crossref': [3196], '(217)': [3199], 'next': [3203, 3409, 4904], 'wanted': [3204, 3410, 3966, 4097], 'determine': [3206, 3343, 3412, 3968, 3990, 5184], 'PS1-': [3216, 3267], 'dependent.': [3217], 'bshows': [3220], 'brain': [3223, 4019], 'accumulation': [3231, 4045, 4497], 'but': [3240, 4238, 4314], 'controls.': [3248], 'dependent': [3268], 'recent': [3272, 4863], '(binding': [3293], 'domain)': [3294], 'multimolecular': [3310], 'complex': [3311], 'Fe65,': [3315, 3769, 3841, 4074], 'Tip60': [3317], 'forms': [3318], 'Once': [3327], 'via': [3337, 3637], 'inserted': [3366], '(Fig.2': [3371, 3438], 'a)': [3372, 3681, 3750], 'co-transfected': [3374], 'Gal4-luciferase': [3377], 'construct': [3379], 'Fe65.': [3383], 'Fig.2': [3384], 'b': [3385, 3830, 4115, 4132], 'shows': [3386, 3542, 3831, 3867, 4000, 4116, 4134, 4299, 4456, 4514], 'lines': [3391], 'dependence.': [3407], 'Performance': [3427], 'c)': [3439], 'indeed': [3445], 'inhibitors.': [3449], 'establish': [3452], 'APLP': [3454, 4105, 4507], 'PS1-dependent,': [3457], 'assays': [3460, 3811, 4065], 'co-transfection': [3465, 4414], 'dominant': [3468], 'negative': [3469], 'D385A.': [3472], 'aspartate': [3474], 'replace': [3480], 'Presenilins': [3482], 'Presenilin-dependent': [3485, 4653], '(29Wolfe': [3488], 'M.S.': [3489, 5019], 'Xia': [3490], 'Ostaszewski': [3492], 'B.L.': [3493], 'Diehl': [3494], 'T.S.': [3495], 'Kimberly': [3496], 'W.T.': [3497, 4431], 'Selkoe': [3498, 4436], 'D.J.': [3499, 4437], 'Nature.': [3500, 5026], '398:': [3502, 5028], '513-517Crossref': [3503], '(1688)': [3506], '30Kim': [3509], 'Leem': [3511], 'J.Y.': [3512], 'Lah': [3513], 'Levey': [3517], 'A.I.': [3518], '43343-43350Abstract': [3528], '(90)': [3536], 'depresses': [3553], 'binding': [3568, 3622, 4262, 4327], '(31Fiore': [3570], 'Zambrano': [3572, 3648, 3944], 'Minopoli': [3574, 3646], 'Donini': [3576], 'Duilio': [3578], '30853-30856Abstract': [3587], '(YENPTY)': [3598], 'required': [3600], 'second': [3620], 'phosphotyrosine': [3621], '(32Duilio': [3642], 'Faraonio': [3644, 3942], '330:': [3655], '513-519Crossref': [3656], '(87)': [3659], 'questioned': [3663], 'acid': [3669, 3691], 'stretch': [3670], '(APLP1CT44': [3675], 'respectively,': [3678], 'could': [3682], 'Additionally,': [3688, 4413], '44-amino': [3690], 'fragment,': [3692], 'comprises': [3694], 'most': [3695], 'released': [3700, 4692], 'upon': [3701], 'cleavage,': [3703, 4350, 4656], 'minimal': [3707], 'needed': [3709], 'sufficient': [3731], 'gene,': [3738], 'whereas': [3739], 'deletion': [3741, 4149], '(APLP1ΔCT': [3745], 'APLP2ΔCT,': [3747], 'abolishes': [3751], '(Fig.': [3754, 4389], 'f).': [3756], 'requires': [3763], 'created': [3771], 'point': [3772, 3796, 3847], 'mutants': [3773], 'APLP2CT44': [3777], 'glycine.': [3789], 'As': [3790], 'Fig.3': [3791], 'shows,': [3793], 'mutants,': [3797, 4150], 'drops': [3801], 'baseline.': [3804], 'performed': [3807, 3862, 3983, 4184], 'pull': [3809], 'same': [3825, 3979], 'mutated.': [3827, 3886], 'much': [3851], 'efficiently.': [3853], 'Last,': [3854], 'confirm': [3856, 4099], 'vivo,': [3860], 'immunoprecipitations.': [3863], 'c': [3866, 4298], 'decreases': [3876], 'Thus,': [3887], 'correlation': [3892], 'Fe65-APLP': [3897], 'interaction.': [3898], 'addition': [3900], 'AID-Fe65': [3903], 'complex-stimulating': [3904], 'interacts': [3910], 'regulate': [3914, 4070], 'its': [3915], 'distribution': [3916, 4072, 4102], 'cytoplasm': [3921, 4229], '33Minopoli': [3935], 'Candia': [3938], 'Bonetti': [3940], '6545-6550Abstract': [3953], '(122)': [3961], 'therefore': [3965], 'accomplish': [3977], 'task.': [3980], 'immunocytochemistry': [3984, 4089], 'localization': [3992], 'APLP2.': [3997, 4757], 'Fig.4': [3998], 'present': [4007, 4254], 'perinuclear': [4010, 4340], 'area': [4011], '(agreeing': [4012], 'previous': [4014], 'immunohistochemistry': [4017], 'sections)': [4020], '(34McNamara': [4021], 'Ruff': [4023], 'B.T.': [4032], '804:': [4036], '45-51Crossref': [4037], '(33)': [4040], 'some': [4044], 'tips': [4048], 'neurites.': [4050], 'test': [4052], 'Gal4-tagged': [4081, 4173], 'APLP1ΔCT': [4084], 'APLP2ΔCT': [4086], 'locate': [4091], 'epitope.': [4094], 'overexpressed': [4104], 'APLP.': [4112, 4129], 'predominantly': [4122], 'outside': [4123, 4157], 'exclude': [4143], 'nucleus;': [4147], 'however,': [4151], 'localized': [4155], 'nucleus,': [4159], 'do': [4160, 4754], 'restrain': [4162], 'nucleus.': [4167], 'Because': [4168], 'concerns': [4170], 'would': [4175, 4279, 4322, 4410], 'act': [4176], 'analysis': [4187], 'GFP-Fe65.': [4198], '(Note': [4199], 'changed': [4202], 'YFP': [4206], 'GFP': [4208], 'fluorophore': [4209], 'allow': [4211], 'compatibility': [4212], 'stain': [4217], 'APLPs.)': [4219], 'restrained': [4225], 'empty': [4241, 4318], 'vector': [4242], 'speculated': [4247], 'small': [4250], 'free': [4263], 'eliminate': [4268], 'entirely': [4271], 'ALID/Fe65': [4277], 'complexes': [4278], 'released,': [4281], 'added': [4283, 5153], '10−6m': [4286], 'growth': [4290], 'inhibit': [4293], 'exclusion': [4303], 'pcDNA3': [4317], 'vector.': [4319], 'consistent': [4324], 'constrained': [4337], 'space': [4341], 'Upon': [4348], 'travel': [4358], 'instability': [4371], 'unable': [4380], '1).': [4390], 'production': [4394, 4485], 'fragments,': [4397], 'Gal4BD-tagged': [4401, 4529], '(so': [4404], 'tagged': [4406, 4474], 'produced).': [4412], 'stabilize': [4420], '(35Kimberly': [4430], 'J.B.': [4433], 'Guenette': [4434], 'S.Y.': [4435], '40288-40292Abstract': [4443], '(397)': [4451], 'extra': [4467, 4520], 'molecular': [4469], 'weight': [4470], 'band': [4471, 4488, 4521], 'present,': [4472], 'presumably': [4473, 4701], 'inhibitors,': [4484], 'inhibited,': [4490], 'increase': [4495], 'C99/C83': [4502], '(C99/C83-like)': [4508], 'intermediate': [4509], 'fragments.': [4510], 'size': [4517, 4526, 4545], 'larger': [4523, 4544, 4552], 'constructs,': [4530], 'contain': [4532], 'APLP1CT44,': [4540], 'APLP2CT44).': [4542], 'indicates': [4546], 'γ-cleavage': [4549, 5177], 'acids,': [4556], 'large': [4558], 'enough': [4559], 'account': [4561, 4944], 'Indeed,': [4567], 'plausible': [4570], 'cleaved,': [4576], 'like': [4578], 'positions': [4583], 'portion.': [4587], 'One': [4588], 'sites': [4592], 'correspond': [4594], 'characterized': [4598], 'Gu': [4600], 'et': [4601, 4953, 5192], 'al.': [4602, 4954, 5193], 'releases': [4661], 'peptides': [4664], 'sequester': [4679], 'cytoplasm.': [4683], 'addition,': [4685], 'our': [4686, 4907, 5272], 'suggest': [4688], 'molecules': [4691], 'enter': [4696], 'too': [4753], 'study': [4759], 'provides': [4760], 'throughout': [4771], 'partially': [4777, 4933], 'explain': [4778], 'exists': [4783], 'development.': [4787], 'possible': [4789, 4922], 'here': [4818], 'artificial': [4823], 'involving': [4825], 'Gal4BD-fusion': [4826], 'APP/APLPs': [4827], 'Gal4-dependent': [4831], 'Discovering': [4834], 'physiological,': [4835], 'target': [4837], 'will': [4845, 5168], 'essential': [4847], 'determining': [4849], 'results': [4852], 'represent': [4857], 'true': [4859], 'phenomenon.': [4861], 'implication': [4864], 'regulation': [4869], '(KAI-1)': [4874], '(12Baek': [4875], 'suggests': [4901], 'step': [4905], 'find': [4912], 'ALID1,': [4925], 'identical,': [4932], 'overlapping,': [4934], 'genes.': [4937], 'discovery': [4939], 'development': [4948], 'phenotypes': [4949], 'Heber': [4952], 'growing': [4994], 'list': [4995], 'including': [4999], '(36De': [5001], 'Cupers': [5006], 'Saftig': [5008], 'Mumm': [5012], 'Schroeter': [5014], 'Schrijvers': [5016], 'Wolfe': [5018], 'Ray': [5020], 'W.J.': [5021], 'Goate': [5022], 'Kopan': [5024], '518-522Crossref': [5029], '(1799)': [5032], 'ErbB4': [5035], '(37Ni': [5036], 'C.Y.': [5037], 'Murphy': [5038], 'M.P.': [5039], 'Golde': [5040, 5244], 'Carpenter': [5042], '294:': [5046], '2179-2181Crossref': [5047], '(756)': [5050], '38Lee': [5053], 'H.J.': [5054], 'Jung': [5055], 'K.M.': [5056], 'Huang': [5057], 'Y.Z.': [5058], 'Bennett': [5059], 'L.B.': [5060], 'Mei': [5063, 5254], 'Kim': [5065], 'T.W.': [5066], '6318-6323Abstract': [5072], '(263)': [5080], 'density': [5084], 'lipoprotein': [5085], 'receptor-related': [5086], '(39May': [5088], 'Reddy': [5090], 'Y.K.': [5091], 'Herz': [5092], '18736-18743Abstract': [5099], '(260)': [5107], 'E-cadherin': [5110], '(40Marambaud': [5111], 'Shioi': [5113], 'Serban': [5115], 'Georgakopoulos': [5117], 'Sarner': [5119], 'Nagy': [5121], 'Baki': [5123], 'Wen': [5125], 'Efthimiopoulos': [5127], 'Shao': [5129], 'Wisniewski': [5131], 'Robakis': [5133], 'N.K.': [5134], 'EMBO': [5135], '1948-1956Crossref': [5139], '(623)': [5142], 'now': [5146], 'complication': [5154], 'designing': [5156], 'prevention': [5161], 'treatment': [5163], 'AD.': [5165], 'Further': [5166], 'work': [5167], 'necessary': [5170], 'localize': [5172], 'APP-specific': [5187], 'inhibitor': [5188], 'Petit': [5191], '(41Petit': [5194], 'Bihel': [5196], 'Alves': [5198], 'da': [5199], 'Costa': [5200], 'Pourquie': [5202], 'Kraus': [5206], '507-511Crossref': [5213], '(193)': [5216], 'inhibits': [5219], 'and/or': [5221], 'too.': [5224], 'gratefully': [5226], 'thank': [5227, 5252, 5263], 'Drs.': [5228], 'Sudhof,': [5230], 'Russo,': [5232], 'Selkoe,': [5235], 'Strooper,': [5238], 'Sisodia,': [5241], 'materials': [5246], 'provided.': [5247], 'technical': [5249], 'assistance': [5250], 'Yong': [5253], 'Zhao,': [5255], 'helpful': [5258], 'advice': [5259], 'discussions': [5261], 'laboratory.': [5269], 'express': [5271], 'appreciation': [5273], 'Dragic': [5277], 'usage': [5280], 'equipment.': [5282]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2058287822', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-13T04:51:16.635791', 'created_date': '2016-06-24'}