Publication Information

{'id': 'https://openalex.org/W2056823151', 'doi': 'https://doi.org/10.1158/1538-7445.am2014-4467', 'title': 'Abstract 4467: Treating brain tumors with targeted-micelles containing rapamycin', 'display_name': 'Abstract 4467: Treating brain tumors with targeted-micelles containing rapamycin', 'publication_year': 2014, 'publication_date': '2014-10-01', 'ids': {'openalex': 'https://openalex.org/W2056823151', 'doi': 'https://doi.org/10.1158/1538-7445.am2014-4467', 'mag': '2056823151'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2014-4467', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5003774562', 'display_name': 'Ann‐Marie Broome', 'orcid': 'https://orcid.org/0000-0002-2384-5212'}, 'institutions': [{'id': 'https://openalex.org/I153297377', 'display_name': 'Medical University of South Carolina', 'ror': 'https://ror.org/012jban78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I153297377']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ann-Marie Broome', 'raw_affiliation_strings': ['Medical University of South Carolina, Charleston, SC.'], 'affiliations': [{'raw_affiliation_string': 'Medical University of South Carolina, Charleston, SC.', 'institution_ids': ['https://openalex.org/I153297377']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109884686', 'display_name': 'Suraj Dixit', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I153297377', 'display_name': 'Medical University of South Carolina', 'ror': 'https://ror.org/012jban78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I153297377']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Suraj K. Dixit', 'raw_affiliation_strings': ['Medical University of South Carolina, Charleston, SC.'], 'affiliations': [{'raw_affiliation_string': 'Medical University of South Carolina, Charleston, SC.', 'institution_ids': ['https://openalex.org/I153297377']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088842777', 'display_name': 'Kayla Miller', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I153297377', 'display_name': 'Medical University of South Carolina', 'ror': 'https://ror.org/012jban78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I153297377']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kayla Miller', 'raw_affiliation_strings': ['Medical University of South Carolina, Charleston, SC.'], 'affiliations': [{'raw_affiliation_string': 'Medical University of South Carolina, Charleston, SC.', 'institution_ids': ['https://openalex.org/I153297377']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084995419', 'display_name': 'Alfred Moore', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I153297377', 'display_name': 'Medical University of South Carolina', 'ror': 'https://ror.org/012jban78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I153297377']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alfred Moore', 'raw_affiliation_strings': ['Medical University of South Carolina, Charleston, SC.'], 'affiliations': [{'raw_affiliation_string': 'Medical University of South Carolina, Charleston, SC.', 'institution_ids': ['https://openalex.org/I153297377']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5014443802', 'display_name': 'Amy‐Lee Bredlau', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I153297377', 'display_name': 'Medical University of South Carolina', 'ror': 'https://ror.org/012jban78', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I153297377']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amy-Lee Bredlau', 'raw_affiliation_strings': ['Medical University of South Carolina, Charleston, SC.'], 'affiliations': [{'raw_affiliation_string': 'Medical University of South Carolina, Charleston, SC.', 'institution_ids': ['https://openalex.org/I153297377']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '74', 'issue': '19_Supplement', 'first_page': '4467', 'last_page': '4467'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10063', 'display_name': 'Nanoparticle-Based Drug Delivery', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10063', 'display_name': 'Nanoparticle-Based Drug Delivery', 'score': 0.9991, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10782', 'display_name': 'Nanoplatforms for cancer theranostics', 'score': 0.9908, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'RNA Interference and Gene Delivery', 'score': 0.9885, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nanocarriers', 'display_name': 'Nanocarriers', 'score': 0.7283324}, {'id': 'https://openalex.org/keywords/targeted-drug-delivery', 'display_name': 'Targeted drug delivery', 'score': 0.4318081}], 'concepts': [{'id': 'https://openalex.org/C18150654', 'wikidata': 'https://www.wikidata.org/wiki/Q17153796', 'display_name': 'Nanocarriers', 'level': 3, 'score': 0.7283324}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.603946}, {'id': 'https://openalex.org/C181389837', 'wikidata': 'https://www.wikidata.org/wiki/Q461809', 'display_name': 'Bioavailability', 'level': 2, 'score': 0.5857233}, {'id': 'https://openalex.org/C2779820397', 'wikidata': 'https://www.wikidata.org/wiki/Q1392806', 'display_name': 'Drug delivery', 'level': 2, 'score': 0.55288815}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.54591674}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.54093784}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.47187486}, {'id': 'https://openalex.org/C11268172', 'wikidata': 'https://www.wikidata.org/wiki/Q421110', 'display_name': 'Micelle', 'level': 3, 'score': 0.46163273}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4576068}, {'id': 'https://openalex.org/C13245373', 'wikidata': 'https://www.wikidata.org/wiki/Q3715494', 'display_name': 'Drug carrier', 'level': 3, 'score': 0.43796152}, {'id': 'https://openalex.org/C126511603', 'wikidata': 'https://www.wikidata.org/wiki/Q1261145', 'display_name': 'Targeted drug delivery', 'level': 3, 'score': 0.4318081}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.27120572}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.25025108}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15194103}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.13198459}, {'id': 'https://openalex.org/C150903083', 'wikidata': 'https://www.wikidata.org/wiki/Q7108', 'display_name': 'Biotechnology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C147789679', 'wikidata': 'https://www.wikidata.org/wiki/Q11372', 'display_name': 'Physical chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C184651966', 'wikidata': 'https://www.wikidata.org/wiki/Q906356', 'display_name': 'Aqueous solution', 'level': 2, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1158/1538-7445.am2014-4467', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S168522863', 'display_name': 'Cancer Research', 'issn_l': '0008-5472', 'issn': ['0008-5472', '1538-7445'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320273', 'host_organization_name': 'American Association for Cancer Research', 'host_organization_lineage': ['https://openalex.org/P4310320273'], 'host_organization_lineage_names': ['American Association for Cancer Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.67, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4309488430', 'https://openalex.org/W4200226131', 'https://openalex.org/W3132615601', 'https://openalex.org/W2896971073', 'https://openalex.org/W2518046561', 'https://openalex.org/W2284960947', 'https://openalex.org/W2111330785', 'https://openalex.org/W2035994152', 'https://openalex.org/W2005818850', 'https://openalex.org/W1978267970'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'development': [2], 'of': [3, 22, 69, 91, 103, 108, 110, 127, 204, 223, 256, 280, 305, 322, 329, 333, 349, 430, 435], 'selectively': [4, 135], 'targeted': [5, 136, 181, 354], 'nanoparticles': [6], 'that': [7, 169], 'can': [8, 188], 'act': [9], 'as': [10, 81, 129, 131, 225], 'drug': [11, 119, 162, 182, 193, 212, 237, 324, 331], 'delivery': [12, 143], 'vehicles': [13], 'is': [14, 38, 262, 336], 'critical': [15], 'for': [16, 40, 138, 180, 200, 208, 297, 439], 'improving': [17], 'the': [18, 87, 99, 106, 115, 118, 124, 175, 191, 198, 205, 215, 220, 257, 277, 281, 326, 330, 334, 375, 377, 380, 405, 431, 436], 'treatment': [19], 'and': [20, 44, 49, 150, 160, 197, 210, 242, 315, 338, 355, 389], 'monitoring': [21], 'glioblastoma,': [23], 'a': [24, 31, 56, 166, 171, 184, 291], 'life': [25], 'threatening': [26], 'disease.': [27], 'Rapamycin': [28], '(Sirolimus,': [29], 'rapa),': [30], 'large,': [32], 'lipophilic': [33], 'carboxylic': [34], 'lactone-lactam': [35], 'macrolide': [36], 'antibiotic,': [37], 'recognized': [39], 'its': [41, 64, 76, 79, 142], 'potent': [42], 'anti-proliferative': [43], 'immunosuppressive': [45], 'effects': [46], 'in': [47, 50, 250, 393, 394], 'vitro': [48], 'vivo.': [51], 'These': [52, 300], 'properties': [53], 'make': [54], 'rapa': [55, 70, 92, 104, 139, 323, 378], 'potential': [57], 'chemotherapeutic': [58], 'agent': [59, 207], 'against': [60], 'several': [61], 'tumors.': [62], 'Despite': [63], 'promising': [65], 'properties,': [66], 'clinical': [67], 'applications': [68], 'have': [71, 287, 302], 'been': [72, 288], 'limited': [73], 'due': [74, 318], 'to': [75, 121, 123, 144, 156, 177, 214, 259, 276, 294, 310, 319, 367], 'hydrophobicity,': [77], 'limiting': [78], 'utility': [80], 'an': [82, 158, 303], 'intravenously': [83], 'administered': [84], 'drug.': [85], 'Presently,': [86], 'commercially': [88], 'available': [89], 'formulations': [90], 'include': [93], 'tablet': [94], 'or': [95, 270], 'oral': [96, 101], 'forms.': [97, 112], 'Nevertheless,': [98], 'low': [100], 'bioavailability': [102], 'limits': [105], 'effectiveness': [107], 'both': [109], 'these': [111, 228, 285], 'In': [113, 154, 283], 'addition,': [114], 'lipophilicity': [116], 'makes': [117], 'susceptible': [120], 'attachment': [122], 'lipid': [125, 248], 'membranes': [126], 'normal': [128], 'well': [130], 'cancer': [132], 'cells.': [133, 381], 'A': [134], 'carrier': [137, 176, 206, 224], 'will': [140], 'enhance': [141], 'malignant': [145], 'cells,': [146], 'avoid': [147], 'non-specific': [148], 'interactions,': [149], 'reduce': [151], 'non-tumor': [152], 'toxicity.': [153], 'order': [155], 'design': [157], 'efficient': [159], 'effective': [161], 'carrier,': [163], 'we': [164], 'created': [165], 'multifunctional': [167], 'nanocarrier': [168], 'contains': [170], 'tailored': [172], 'surface': [173], 'on': [174, 231], 'attach': [178], 'biomolecules': [179], 'delivery;': [183], 'biocompatible': [185], 'coating': [186], 'which': [187], 'efficiently': [189], 'encapsulate': [190], 'hydrophobic': [192], 'thereby': [194], 'reducing': [195], 'cytotoxicity;': [196], 'capability': [199], 'stimuli-induced': [201], '(pH)': [202], 'disruption': [203], 'slow': [209], 'controlled': [211], 'release': [213], 'desired': [216], 'environment,': [217], 'Micelles': [218, 234], 'are': [219, 238], 'preferred': [221], 'choice': [222], 'they': [226], 'fulfill': [227], 'requirements': [229], 'based': [230], 'their': [232], 'composition.': [233], 'containing': [235, 425], 'rapamycin': [236], 'synthesized': [239], 'using': [240], 'PEG-PE-Amine': [241], 'N-palmitoyl': [243], 'homocysteine': [244], '(PHC,': [245], 'pH': [246, 252], 'sensitive': [247], 'breaks': [249], 'endosome': [251], '5.5).': [253], 'Specific': [254], 'targeting': [255], 'micelles': [258, 286, 301], 'glioblastoma': [260, 350], 'cells': [261, 351], 'achieved': [263], 'by': [264], 'PDGF': [265], '(platelet': [266], 'derived': [267], 'growth': [268, 273], 'factor)': [269, 274], 'EGF': [271], '(epidermal': [272], 'coupled': [275], 'amine': [278], 'moeity': [279], 'DSPE-PEG.': [282], 'addition': [284], 'labeled': [289], 'with': [290, 353, 423], 'NIR': [292], 'fluorphore': [293], 'track': [295], 'them': [296], 'cellular': [298, 343], 'uptake.': [299], 'advantage': [304], 'small': [306], 'size': [307], '(<50': [308], 'nm,': [309], 'cross': [311], 'blood': [312], 'brain': [313, 421], 'barrier)': [314], 'reduced': [316], 'toxicity': [317], 'robust': [320], 'packaging': [321], 'inside': [325], 'core.': [327], 'Leaching': [328], 'out': [332], 'micelle': [335], 'prevented': [337], 'reduces': [339], 'offsite': [340], 'cytotoxicity.': [341], 'Preliminary': [342], 'uptake': [344], 'studies': [345, 392], 'via': [346], 'fluorescence': [347], 'imaging': [348], 'treated': [352], 'untargeted': [356], 'labeled-micellar': [357], 'particles': [358], 'demonstrate': [359], 'receptor-mediated': [360], 'endocytosis.': [361], 'Uptake': [362], 'occurs': [363], 'rapidly': [364], 'within': [365], '1': [366], '4': [368], 'hours': [369], 'after': [370], 'treatment.': [371], 'Once': [372], 'released': [373], 'from': [374], 'micelle,': [376], 'kills': [379], 'Future': [382], 'experiments': [383], 'involve': [384], 'performing': [385], 'cytotoxicity': [386], 'assays,': [387], 'pharmacokinetic': [388], 'tissue': [390], 'distribution': [391], 'vivo': [395], 'animal': [396], 'models.': [397], 'Note:': [398], 'This': [399], 'abstract': [400], 'was': [401], 'not': [402], 'presented': [403], 'at': [404], 'meeting.': [406], 'Citation': [407], 'Format:': [408], 'Ann-Marie': [409], 'Broome,': [410], 'Suraj': [411], 'K.': [412], 'Dixit,': [413], 'Kayla': [414], 'Miller,': [415], 'Alfred': [416], 'Moore,': [417], 'Amy-Lee': [418], 'Bredlau.': [419], 'Treating': [420], 'tumors': [422], 'targeted-micelles': [424], 'rapamycin.': [426], '[abstract].': [427], 'In:': [428], 'Proceedings': [429], '105th': [432], 'Annual': [433], 'Meeting': [434], 'American': [437], 'Association': [438], 'Cancer': [440, 451], 'Research;': [441], '2014': [442], 'Apr': [443], '5-9;': [444], 'San': [445], 'Diego,': [446], 'CA.': [447], 'Philadelphia': [448], '(PA):': [449], 'AACR;': [450], 'Res': [452], '2014;74(19': [453], 'Suppl):Abstract': [454], 'nr': [455], '4467.': [456], 'doi:10.1158/1538-7445.AM2014-4467': [457]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2056823151', 'counts_by_year': [], 'updated_date': '2024-12-08T13:03:48.229971', 'created_date': '2016-06-24'}