Title: Fmoc solid phase synthesis of serine phosphopeptides via selective protection of serine and on resin phosphorylation
Abstract: An Fmoc based solid phase method for the synthesis of phosphoserine peptides has been developed which is amenable to standard protocols on automated synthesizers. The serine residue to be phosphorylated is protected with a t-butyldimethylsilyl group which is selectively removed from the resin bound protected peptide. On resin phosphorylation and final deprotection/cleavage are performed in standard fashion to yield serine phosphopeptides of significant length and complexity.
Publication Year: 1994
Publication Date: 1994-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 19
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