Title: Evaluation of monomethoxytrityl and dimethoxytrityl as orthogonal amino protecting groups in Fmoc solid phase peptide synthesis
Abstract: Amino acid derivatives protected at the α- or side chain amino function with mono- as well as dimethoxytrityl were successfully prepared by a one-step procedure. These derivatives were evaluated for their utilization in solid phase peptide synthesis (SPPS), particularly with respect to the selective detritylation in the presence of other acid labile protecting groups to allow for the preparation of multiple, branched or cyclized peptide structures as well as for site specific post-assembly manipulations.
Publication Year: 1998
Publication Date: 1998-03-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 23
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