Publication Information

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'https://openalex.org/W2418865968', 'https://openalex.org/W4232748180', 'https://openalex.org/W4255535345', 'https://openalex.org/W77084047'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2148612803', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166', 'https://openalex.org/W1489783725'], 'abstract_inverted_index': {'Mechanisms': [0, 263, 930], 'of': [1, 14, 19, 53, 64, 105, 188, 195, 240, 252, 261, 264, 277, 282, 316, 327, 368, 451, 458, 503, 515, 524, 532, 544, 581, 685, 757, 763, 771, 777, 944, 1058, 1066, 1072, 1077, 1098, 1184, 1255, 1264, 1294, 1303, 1339, 1343, 1353, 1367, 1404, 1626, 1679, 1699, 1728, 1797, 1807, 1830, 1918, 2037, 2133, 2138, 2206, 2383, 2393, 2404, 2414, 2434, 2445, 2454, 2462, 2566, 2631, 2663, 2678, 2707, 2716, 2745, 2810, 2818, 2868, 3156, 3161, 3177, 3179, 3195, 3201, 3209, 3212, 3225, 3228, 3334, 3481, 3516, 3518, 3521, 3530, 3562, 3628, 3863, 4013, 4181, 4195, 4205, 4233, 4241, 4276], 'cell': [2, 45, 241, 265, 308, 504, 680, 945, 1047, 1060, 1105, 1713, 1809, 1822, 2124, 2384, 2665, 3407, 3636, 3736], 'death': [3, 32, 46, 242, 253, 266, 295, 309, 505, 516, 946, 1122, 1130, 1714, 1838, 2385, 2666], 'in': [4, 48, 94, 112, 118, 130, 136, 139, 149, 166, 180, 206, 237, 243, 267, 311, 357, 375, 381, 393, 399, 402, 412, 429, 443, 469, 500, 506, 578, 585, 676, 753, 1090, 1117, 1300, 1322, 1628, 1666, 1686, 1716, 2127, 2391, 2408, 2439, 2516, 2523, 2563, 2614, 2686, 2733, 2758, 2803, 2858, 3002, 3008, 3024, 3133, 3325, 3329, 3411, 3452, 3537, 3603, 3640, 3676, 3866, 3872, 3890, 3900, 3906, 3925, 3944, 3985, 3990, 4030, 4178, 4185, 4221, 4243, 4258, 4265, 4273, 4285], 'pancreatitis': [5, 21, 49, 93, 154, 268, 284, 312, 356, 417, 527, 586, 765, 2140, 2208, 2409, 2568, 2683, 2800], 'remain': [6, 269], 'unknown.': [7, 270], 'Parenchymal': [8, 271], 'necrosis': [9, 25, 35, 148, 165, 179, 272, 288, 298, 411, 428, 442, 697, 772, 939, 1053, 1280, 1729, 1781, 1818, 1848, 1856, 1920, 1933, 1936, 2407, 2466, 2530, 3180, 4184, 4286], 'is': [10, 185, 273, 448, 528, 666, 1044, 1054, 1123, 1250, 1272, 1292, 1478, 1618, 1664, 1782, 1792, 1801, 1824, 1921, 2131, 2450], 'a': [11, 40, 192, 256, 274, 303, 455, 519, 1289, 1315, 1804, 1808, 1827, 2451, 2524, 2736, 2859, 3159, 3238, 3344, 3412, 3453, 3505, 3641, 3677, 3921, 3956, 4292], 'major': [12, 275, 673], 'complication': [13, 276], 'pancreatitis;': [15, 278], 'also,': [16, 279], 'the': [17, 51, 58, 61, 75, 95, 113, 119, 131, 150, 207, 211, 238, 250, 280, 314, 321, 324, 338, 358, 376, 382, 394, 413, 470, 474, 501, 513, 542, 570, 582, 669, 678, 761, 769, 1059, 1067, 1081, 1095, 1099, 1103, 1118, 1126, 1256, 1286, 1295, 1301, 1330, 1479, 1483, 1489, 1623, 1661, 1708, 1845, 1922, 2134, 2200, 2215, 2380, 2397, 2402, 2412, 2427, 2446, 2455, 2518, 2556, 2626, 2646, 2650, 2743, 2776, 2781, 2796, 2829, 2839, 3145, 3330, 3440, 3549, 3621, 3672, 3711, 3740, 3864, 3891, 3926, 3945, 4031, 4130, 4179, 4190, 4193, 4203, 4239, 4250, 4263, 4280, 4283], 'severity': [18, 281, 762], 'experimental': [20, 283, 683, 755, 764, 2207], 'correlates': [22, 285, 767], 'directly': [23, 286, 766], 'with': [24, 28, 67, 78, 125, 159, 222, 287, 291, 330, 341, 388, 422, 485, 768, 775, 1317, 1538, 1706, 2211, 2219, 2528, 2770, 2877, 2886, 3037, 3048, 3188, 3191, 3222, 3491, 3543, 3598, 3887, 3912, 3920, 3980, 4023, 4050, 4246, 4249], 'and': [26, 50, 71, 74, 81, 145, 163, 235, 289, 313, 334, 337, 344, 408, 426, 498, 539, 541, 698, 773, 938, 1049, 1061, 1064, 1083, 1113, 1319, 1328, 1487, 1493, 1672, 1697, 1702, 2126, 2214, 2406, 2410, 2464, 2531, 2560, 2603, 2620, 2622, 2628, 2692, 2724, 2792, 2838, 2841, 2849, 2853, 3006, 3010, 3026, 3042, 3139, 3153, 3199, 3427, 3439, 3465, 3496, 3523, 3548, 3558, 3571, 3587, 3608, 3630, 3671, 3709, 3716, 3723, 3735, 3742, 3850, 3914, 4000, 4004, 4044, 4056, 4060, 4074, 4086, 4101, 4127, 4129, 4145, 4156, 4170, 4183, 4208, 4214, 4262], 'inversely': [27, 290, 774], 'apoptosis.': [29, 292], 'Thus,': [30, 169, 293, 432], 'shifting': [31, 294], 'responses': [33, 254, 296, 517, 2677], 'from': [34, 178, 297, 441, 1931, 2379, 3173, 3231, 4067, 4076, 4088, 4096, 4103, 4110, 4117, 4136, 4150, 4166], 'to': [36, 248, 299, 511, 693, 1125, 1336, 2386, 2644, 2674, 2702, 2880, 2889, 3016, 3144, 3853, 3955, 4041, 4046, 4229], 'apoptosis': [37, 70, 80, 106, 144, 162, 174, 300, 333, 343, 369, 407, 425, 437, 699, 778, 1043, 1185, 1344, 1354, 1368, 1627, 1854, 2213, 2387, 2405, 2463, 2534, 4182, 4196, 4222, 4257, 4266], 'may': [38, 301, 2668], 'have': [39, 302, 690, 1631], 'therapeutic': [41, 257, 304, 520, 2672], 'value.': [42, 305], 'To': [43, 306], 'determine': [44, 307], 'pathways': [47, 310, 1183], 'possibility': [52, 315, 2413], 'necrosis/apoptosis': [54, 317, 2415, 2647], 'switch,': [55, 318], 'we': [56, 319, 2400, 2425, 2641, 2894, 3243, 3348, 3746, 4174], 'utilized': [57, 320, 2426], 'differences': [59, 322, 933, 2428, 2613], 'between': [60, 323, 2429, 2625], 'rat': [62, 96, 114, 151, 208, 325, 359, 377, 414, 471, 1668, 2627, 4169, 4191, 4251, 4281], 'model': [63, 326], 'cerulein': [65, 92, 328, 355, 2520, 2632, 2746, 2771, 2782, 4115, 4172, 4206, 4260, 4277], 'pancreatitis,': [66, 329, 677, 687, 4173, 4261], 'relatively': [68, 331, 2216, 2459], 'high': [69, 82, 332, 345, 2460], 'low': [72, 335, 2465], 'necrosis,': [73, 336, 2125, 2130, 2221], 'mouse': [76, 120, 132, 167, 212, 339, 383, 395, 430, 475, 2629, 4171, 4259], 'model,': [77, 133, 152, 340, 396, 415, 2822, 4192, 4252, 4282], 'little': [79, 342, 665, 1620, 2533], 'necrosis.': [83, 197, 346, 460], 'We': [84, 198, 347, 461, 1630, 2610], 'found': [85, 199, 348, 462, 2611], 'that': [86, 200, 349, 463, 776, 1407, 1660, 1723, 1791, 1833, 2203, 2377, 2667], 'caspases': [87, 170, 350, 433, 1266], 'were': [88, 351, 2642, 2731, 2785, 2824, 2833, 2843, 2856, 3014, 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'triggered': [127, 224, 390, 487, 1274, 1786, 1836], 'activation': [129, 392, 1076, 1254, 1263, 1411, 1698], 'implicating': [134, 397], 'blockade': [138, 401], 'pancreatitis.': [140, 181, 244, 262, 403, 444, 507, 525, 758, 1629, 2395, 2436, 2633, 2680, 4278], 'Caspase': [141, 214, 404, 477, 2719, 3338, 4122, 4141], 'inhibitors': [142, 405, 2720, 4142], 'decreased': [143, 164, 406, 427], 'markedly': [146, 409], 'stimulated': [147, 161, 410, 424], 'worsening': [153, 416], 'parameters.': [155, 418], 'Conversely,': [156, 419], 'induction': [158, 221, 421, 484], 'only': [172, 435, 1913, 4288], 'mediate': [173, 436], 'also': [176, 439], 'protect': [177, 440], 'One': [182, 445], 'protective': [183, 446], 'mechanism': [184, 447], 'through': [186, 449, 695, 2417, 3030], 'receptor-interacting': [189, 452, 1360, 1923], '(RIP),': [191, 454], 'key': [193, 230, 456, 493], 'mediator': [194, 457, 1917], '"programmed"': [196, 459], 'RIP': [201, 217, 225, 236, 464, 480, 488, 499, 1927, 2038, 2623], 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'Slavin': [597], 'J.': [598, 599, 620, 629, 631, 741, 820, 907, 969, 1153, 1190, 1218, 1231, 1427, 1456, 1606, 1644, 1896, 1901, 1940, 1950, 1955, 1990, 2019, 2188, 2267, 2354, 2478, 2546, 2574, 2908, 2988, 3083, 3257, 3275, 3305, 3361, 3760, 3778, 3808], 'Pathol.': [600], '2000;': [601, 1193, 1523, 1993], '190:': [602], '117-125Crossref': [603], '(456)': [606], 'Scholar,': [608, 627, 645, 729, 808, 827, 849, 877, 903, 916, 963, 978, 994, 1011, 1028, 1147, 1162, 1198, 1226, 1435, 1452, 1511, 1576, 1745, 1762, 1881, 1970, 2000, 2063, 2080, 2097, 2161, 2182, 2255, 2274, 2296, 2324, 2350, 2363, 2485, 2580, 2915, 2945, 2973, 3068, 3264, 3290, 3376, 3767, 3793, 3818], '3Gukovsky': [609], 'I.': [610, 1637, 2171, 2898, 2977, 3072, 3247, 3268, 3294, 3354, 3384, 3750, 3771, 3797, 3826], 'Gukovskaya': [611, 852, 2299, 2488, 2899, 2948, 3248, 3387, 3751, 3829], 'A.S.': [612, 701, 780, 918, 1635, 2227, 2365, 2900, 2917, 2975, 3057, 3070, 3098, 3249, 3266, 3292, 3352, 3388, 3752, 3769, 3795, 3830], 'Blinman': [613, 2901, 3250, 3753], 'T.A.': [614, 2902, 3251, 3754], 'Zaninovic': [615, 704, 783, 2230, 2903, 2920, 2978, 3073, 3101, 3252, 3295, 3755, 3798], 'V.': [616, 705, 784, 1889, 2231, 2904, 2921, 2979, 3074, 3102, 3253, 3296, 3756, 3799], 'Pandol': [617, 712, 791, 862, 919, 1642, 2238, 2309, 2366, 2498, 2905, 2928, 2958, 2986, 3058, 3081, 3109, 3254, 3273, 3303, 3359, 3385, 3757, 3776, 3806, 3827], 'S.J.': [618, 713, 792, 863, 920, 1643, 2239, 2310, 2367, 2499, 2906, 2929, 2959, 2987, 3059, 3082, 3110, 3255, 3274, 3304, 3360, 3386, 3758, 3777, 3807, 3828], 'Am.': [619, 630, 740, 819, 906, 2266, 2353, 2477, 2545, 2907, 3256, 3759], 'Physiol.': [621, 742, 821, 908, 2268, 2355, 2479, 2547, 2909, 3258, 3761], '1998;': [622, 633, 896, 1219, 1904, 2343, 2910, 3259, 3762], '275:': [623, 2911, 3260, 3763], 'G1402-G1414Crossref': [624, 2912, 3261, 3764], '4Norman': [628], 'Surg.': [632], '175:': [634], '76-83Abstract': [635], 'Full': [636, 638, 720, 722, 799, 801, 870, 1237, 1239, 1526, 1528, 1650, 1652, 1961, 1963, 2025, 2027, 2246, 2248, 2317, 2506, 2936, 2938, 2966, 3117, 3119, 3281, 3283, 3367, 3369, 3393, 3395, 3784, 3786, 3835, 3837], 'Text': [637, 639, 721, 723, 800, 802, 871, 1238, 1240, 1527, 1529, 1651, 1653, 1962, 1964, 2026, 2028, 2247, 2249, 2318, 2507, 2937, 2939, 2967, 3118, 3120, 3282, 3284, 3368, 3370, 3394, 3396, 3785, 3787, 3836, 3838], 'PDF': [640, 724, 803, 872, 1241, 1530, 1654, 1965, 2029, 2250, 2319, 2508, 2940, 2968, 3121, 3285, 3371, 3397, 3788, 3839], '(672)': [643], '5Steer': [646], 'M.L.': [647, 739, 818, 889, 2265, 2336, 2476, 2544], 'Baillieres': [648], 'Best.': [649], 'Pract.': [650], 'Res.': [651, 840, 894, 1020, 1581, 1771, 2089, 2287, 2341], 'Clin.': [652, 1607, 2989, 3084, 3306, 3809], '1999;': [654, 956, 1140, 1234], '13:': [655], '213-225Crossref': [656], '(68)': [659], 'By': [662, 1814, 2514, 2634], 'contrast,': [663, 1815, 2515], 'very': [664, 1619, 2532], 'known': [667, 1621], 'about': [668, 1622], 'mechanisms': [670, 1625, 1710, 2036, 2403, 2637], 'mediating': [671, 1711], 'another': [672], 'pathologic': [674], 'parenchymal': [679], 'death.': [681], 'In': [682, 1285, 1536, 1689, 1704, 2396, 2780, 2820, 3094, 4168, 4189, 4279], 'models': [684, 756, 2433, 2565, 2630, 2652, 4275], 'acute': [686, 2139, 2394, 2435, 2567, 2679], 'acinar': [688, 1670, 1687, 2664, 3165, 3406, 3635], 'cells': [689, 1112, 1671, 1930, 3166, 4235], 'shown': [692, 1633], 'die': [694], 'both': [696, 3710, 4274], '(6Gukovskaya': [700, 779, 2226, 3097], 'Perkins': [702, 781, 2228, 2918, 3099], 'P.': [703, 782, 855, 861, 954, 1138, 1870, 1900, 1986, 2111, 2173, 2229, 2302, 2308, 2491, 2497, 2919, 2951, 2957, 3100], 'Sandoval': [706, 785, 2232, 2922, 2982, 3077, 3103, 3299, 3802], 'D.': [707, 786, 851, 1603, 1866, 1883, 2107, 2233, 2298, 2487, 2923, 2947, 2983, 3078, 3104, 3300, 3803], 'Rutherford': [708, 787, 2234, 2924, 3105], 'Fitzsimmons': [710, 789, 2236, 2926, 3107], 'T.': [711, 790, 1565, 2237, 2927, 3108], 'Poucell-Hatton': [714, 793, 864, 2240, 2311, 2500, 2930, 2960, 3111], 'Gastroenterology.': [716, 795, 866, 2242, 2313, 2502, 2932, 2962, 3113, 3389, 3831], '1996;': [717, 796, 842, 867, 1874, 2115, 2243, 2289, 2314, 2503, 2933, 2963, 3114], '110:': [718, 797, 1610, 2244, 2934, 3115], '875-884Abstract': [719, 798, 2245, 2935, 3116], '(146)': [727, 806, 2253, 2943, 3124], '7Kaiser': [730, 809, 2256], 'A.M.': [731, 810, 2257, 2468, 2536], 'Saluja': [732, 736, 811, 815, 890, 2258, 2262, 2337, 2469, 2473, 2537, 2541], 'A.K.': [733, 812, 891, 2259, 2338, 2470, 2538], 'Sengupta': [734, 813, 2260, 2471, 2539], 'A.': [735, 814, 829, 853, 859, 1034, 1204, 1980, 2261, 2276, 2300, 2306, 2472, 2489, 2495, 2540, 2949, 2955], 'Steer': [738, 817, 836, 888, 2264, 2283, 2335, 2475, 2543], '1995;': [743, 822, 2269, 2480, 2548], '269:': [744, 823, 2270, 2481, 2549], 'C1295-C1304Crossref': [745, 824, 2271, 2482, 2550], 'The': [749, 1247, 1474, 1912, 2035, 2599, 2657, 3033, 3510, 3583, 3698, 3877, 3929, 4033, 4219], 'apoptosis/necrosis': [750], 'ratio': [751], 'varies': [752], 'different': [754], 'Of': [759], 'note,': [760], 'extent': [770, 2461, 4180, 4194], '8Saluja': [828, 2275], 'Hofbauer': [830, 882, 2277, 2329], 'B.': [831, 883, 1599, 1952, 1988, 2278, 2330, 3962], 'Yamaguchi': [832, 2279], 'Y.': [833, 1517, 1553, 1557, 1639, 2002, 2280, 3270, 3356, 3773], 'Yamanaka': [834, 2281], 'K.': [835, 1547, 1858, 2099, 2282], 'Biochem.': [838, 892, 970, 1154, 2285, 2339], 'Biophys.': [839, 893, 2286, 2340], 'Commun.': [841, 895, 2288, 2342], '220:': [843, 2290], '875-878Crossref': [844, 2291], '(59)': [847, 2294], '9Sandoval': [850, 2297, 2486, 2946], 'Reavey': [854, 2301, 2490, 2950], 'Gukovsky': [856, 1636, 2303, 2492, 2952, 2976, 2984, 3071, 3079, 3267, 3293, 3301, 3353, 3383, 3770, 3796, 3804, 3825], 'Sisk': [858, 2305, 2494, 2954], 'Braquet': [860, 2307, 2496, 2956], '111:': [868, 2315, 2504, 2964], '1081-1091Abstract': [869, 2316, 2505, 2965], '(226)': [875, 2322, 2511, 2971], '10Bhatia': [878, 2325], 'Wallig': [880, 2327], 'M.A.': [881, 2328], 'Lee': [884, 2331], 'H.S.': [885, 2332], 'Frossard': [886, 2333], 'J.L.': [887, 1984, 2334], '246:': [897, 2344], '476-483Crossref': [898, 2345], '(119)': [901, 1657, 2348, 3288, 3374, 3791], '11Bhatia': [904, 2351], '286:': [910, 2357], 'G189-G196Crossref': [911, 2358], '(186)': [914, 2361], '12Gukovskaya': [917, 2364], 'Pancreatology.': [921, 2174, 2368, 3060], '4:': [923, 2370, 3062], '567-586Crossref': [924, 2371, 3063], '(136)': [927, 2374, 3066], 'underlying': [931], 'are': [934, 940, 1087, 1180, 1400, 1715, 1725, 2045, 2209, 2555, 3512], 'known.': [936], 'Apoptosis': [937, 1093], 'two': [941, 1181, 1726, 2430, 2651, 2806], 'main': [942], 'types': [943, 1727], '(13Fiers': [947, 1131], 'W.': [948, 952, 1132, 1136, 1894, 1898], 'Beyaert': [949, 1133, 1884], 'Declercq': [951, 1135, 1893], 'Vandenabeele': [953, 1137, 1899], 'Oncogene.': [955, 1139], '18:': [957, 1141], '7719-7730Crossref': [958, 1142], '(760)': [961, 1145], '14Assuncao': [964, 1148], 'G.C.': [965, 1149], 'Linden': [966, 1150], 'Eur.': [968, 1152], '271:': [972, 1156], '1638-1650Crossref': [973, 1157], '(253)': [976, 1160], '15Edinger': [979, 1163], 'A.L.': [980, 1164, 1731, 2049], 'Thompson': [981, 1165, 1732, 2050], 'C.B.': [982, 1166, 1733, 2051], 'Opin.': [984, 1168, 1735, 2053], 'Cell': [985, 1019, 1169, 1443, 1463, 1502, 1736, 1770, 2054, 2088, 3524, 4068], 'Biol.': [986, 1003, 1170, 1232, 1444, 1503, 1645, 1737, 1754, 1956, 2020, 2055, 2072, 3276, 3362, 3779, 3971], '16:': [988, 1172, 1739, 2057], '663-669Crossref': [989, 1173, 1740, 2058], '(1121)': [992, 1176, 1743, 2061], '16Leist': [995, 1746, 2064], 'Jaattela': [997, 1748, 2066], 'Nat.': [999, 1440, 1499, 1750, 1991, 2068], 'Rev.': [1000, 1441, 1500, 1751, 2069], 'Mol.': [1001, 1442, 1501, 1752, 2070], 'Cell.': [1002, 1522, 1753, 2071], '2001;': [1004, 1428, 1755, 2073], '2:': [1005, 1756, 2074], '589-598Crossref': [1006, 1757, 2075], '(1389)': [1009, 1760, 2078], '17Proskuryakov': [1012, 1763, 2081], 'S.Y.': [1013, 1764, 2082], 'Konoplyannikov': [1014, 1765, 2083], 'A.G.': [1015, 1766, 2084], 'Gabai': [1016, 1767, 2085], 'V.L.': [1017, 1768, 2086], 'Exp.': [1018, 1769, 1902, 2087], '2003;': [1021, 1569, 1772, 1958, 2090, 2175, 3390, 3832], '283:': [1022, 1773, 2091], '1-16Crossref': [1023, 1774, 2092], '(565)': [1026, 1777, 2095], '18Reed': [1029], 'J.C.': [1030], 'Doctor': [1031], 'K.S.': [1032], 'Godzik': [1033], 'Sci.': [1035, 1192], 'STKE.': [1036], '2004.': [1037], ':': [1039], 're9Google': [1040], 'Morphologically,': [1042], 'manifested': [1045], 'by': [1046, 1056, 1252, 1262, 1275, 1676, 1787, 1795, 1811, 1826, 2441, 2458, 2700, 2805, 2835, 3022, 3028, 3044, 3620, 3686, 3848, 3860, 3949, 4018, 4038, 4236], 'shrinkage': [1048], 'chromatin': [1050, 2883, 3052], 'condensation,': [1051], 'whereas': [1052, 1102], 'characterized': [1055, 1794, 2457, 2562], 'swelling': [1057], 'its': [1062, 1107, 2043], 'organelles': [1063, 3202], 'rupture': [1065], 'plasma': [1068, 1100, 3196], 'membrane.': [1069], 'Biochemical': [1070], 'hallmarks': [1071], 'apoptosis,': [1073, 1707], 'such': [1074, 1267, 1306], 'as': [1075, 1268, 1307, 1803, 2040, 2042, 2735, 2760, 2893, 3242, 3347, 3514, 3610, 3745], 'specific': [1078, 3471], 'cysteine': [1079], 'proteases,': [1080], 'internucleosomal': [1084], 'DNA': [1085, 2891, 3134], 'fragmentation,': [1086], 'usually': [1088], 'absent': [1089], 'necrotic': [1091, 1104, 1121, 1712, 2381], 'cells.': [1092, 1688], 'preserves': [1094], 'structural': [1096], 'integrity': [1097], 'membrane,': [1101, 1298], 'releases': [1106], 'constituents,': [1108], 'damage': [1110], 'neighboring': [1111], 'promote': [1114], 'infiltration': [1116, 3214], 'organ.': [1119], 'Therefore,': [1120], '"deadlier"': [1124], 'organism': [1127], 'than': [1128], 'apoptotic': [1129, 1662, 3055, 4234], 'There': [1179], 'distinct': [1182], '(19Lee': [1186], 'H.C.': [1187], 'Wei': [1188], 'Y.H.': [1189], 'Biomed.': [1191], '7:': [1194], '2-15Crossref': [1195], '20Scaffidi': [1199], 'C.': [1200, 1206, 1513, 1864, 2105, 2163], 'Fulda': [1201], 'Srinivasan': [1203], 'Friesen': [1205], 'Li': [1207, 1516, 1518, 1552], 'F.': [1208], 'Tomaselli': [1209], 'K.J.': [1210, 3382, 3824], 'Debatin': [1211], 'K.M.': [1212], 'Krammer': [1213], 'P.H.': [1214], 'Peter': [1215], 'M.E.': [1216], 'EMBO': [1217, 1426], '17:': [1220], '1675-1687Crossref': [1221], '(2633)': [1224], '21Wolf': [1227], 'B.B.': [1228], 'Green': [1229], 'D.R.': [1230], 'Chem.': [1233, 1646, 1957, 2021, 3277, 3363, 3780], '274:': [1235], '20049-20052Abstract': [1236], '(865)': [1244], 'extrinsic': [1248], 'pathway': [1249, 1271], 'initiated': [1251], 'receptor-induced': [1253], 'initiator': [1257], 'caspase-8': [1258, 3475], '(or': [1259, 1819], 'caspase-10)': [1260], 'followed': [1261], 'effector': [1265], 'caspase-3.': [1269], 'This': [1270], 'typically': [1273], '"death': [1276], 'receptors",': [1277], 'e.g.': [1278], 'tumor': [1279, 1847, 1932], 'factor': [1281, 1849], 'receptor': [1282, 1850], 'or': [1283, 1590, 1855, 2728, 2753, 2885, 3050, 3233, 3332, 3405, 3477, 3634, 3738, 3885], 'Fas.': [1284], 'intrinsic': [1287], 'pathway,': [1288], 'critical': [1290, 2661], 'event': [1291], 'permeabilization': [1293], 'mitochondrial': [1296, 1693], 'outer': [1297], 'resulting': [1299, 1321], 'release': [1302, 1696], 'pro-apoptotic': [1304], 'factors': [1305], 'cytochrome': [1308, 1312, 1694, 4053, 4083], 'c.': [1309, 4054], 'Once': [1310], 'released,': [1311], 'c': [1313, 1695], 'forms': [1314, 2205], 'complex': [1316], 'Apaf-1': [1318], 'procaspase-9,': [1320], 'caspase-9': [1323, 3478], 'activation.': [1324], 'Caspase-9': [1325], 'further': [1326], 'cleaves': [1327], 'activates': [1329], 'effectors': [1331], '(e.g.': [1333], 'caspase-3)': [1334], 'leading': [1335], 'subsequent': [1337], 'cellular': [1340, 1789, 1798], 'constituents.': [1341], 'Inhibitor': [1342], 'proteins': [1345, 1406, 3984, 4015], '(IAPs)': [1346], '2The': [1347], 'abbreviations': [1348], 'used': [1349, 2559, 3724], 'are:': [1350], 'IAP,': [1351], 'protein;': [1355, 1358, 1361, 1369], 'FLIP,': [1356], 'FLICE-inhibitory': [1357], 'RIP,': [1359, 4085], 'Q-VD-OPH,': [1362], 'Q-Val-Asp(non-O-methylated)-Oph;': [1363], 'Z-D-DCB,': [1370], 'Z-Asp-2,6-dichlorobenzoyloxymethylketone;': [1371], 'Z,': [1372], 'benzyloxycarbonyl;': [1373], 'fmk,': [1374], 'fluoromethyl': [1375], 'ketone;': [1376], 'CCK-8,': [1377], 'cholecystokinin-8;': [1378], 'TUNEL,': [1379], 'terminal': [1380, 3136], 'deoxynucleotidyl': [1381, 3137], 'transferase-mediated': [1382], 'dUTP': [1383, 3142], 'nick': [1384], 'end': [1385], 'labeling;': [1386], 'CHAPS,': [1387, 3464], '3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic': [1388], 'acid;': [1389], 'AMC,': [1390], '7-amino-4-methylcoumarin;': [1391], 'ERK,': [1392], 'extracellular': [1393], 'signal-regulated': [1394], 'kinase;': [1395], 'E3,': [1396], 'ubiquitin-protein': [1397], 'isopeptide': [1398], 'ligase.': [1399], 'important': [1402], 'class': [1403], 'endogenous': [1405], 'negatively': [1408], 'regulate': [1409], '(22Bratton': [1412], 'S.B.': [1413, 1454], 'Walker': [1414], 'G.': [1415, 1549, 1887, 1892, 2165, 2572, 2584], 'Srinivasula': [1416], 'S.M.': [1417], 'Sun': [1418], 'X.M.': [1419], 'Butterworth': [1420, 1457], 'Alnemri': [1422], 'E.S.': [1423], 'Cohen': [1424, 1461], 'G.M.': [1425, 1462, 2010], '20:': [1429], '998-1009Crossref': [1430], '(342)': [1433, 1614], '23Salvesen': [1436], 'G.S.': [1437, 1496], 'Duckett': [1438, 1459, 1497], 'C.S.': [1439, 1460, 1498], '2002;': [1445, 1466, 1504, 1609, 1647, 3278, 3364, 3781, 3972], '3:': [1446, 1505, 2176], '401-410Crossref': [1447, 1506], '(1581)': [1450, 1509], '24Bratton': [1453], 'Lewis': [1455], 'Death': [1464], 'Differ.': [1465], '9:': [1467], '881-892Crossref': [1468], '(118)': [1471], 'IAP': [1476], 'most': [1480, 2135, 2557], 'potent': [1481], 'among': [1482], 'eight': [1484], 'mammalian': [1485], 'IAPs': [1486], 'inhibits': [1488], 'mitochondria-driven': [1490], 'caspases-9,': [1491, 1700], '-3,': [1492], '-7': [1494], '(23Salvesen': [1495], '25Du': [1512], 'Fang': [1514], 'L.': [1519, 1946], 'Wang': [1520], 'X.': [1521], '102:': [1524], '33-42Abstract': [1525], '(2941)': [1533], 'contrast': [1537, 1705], 'other': [1539, 3154], 'disease': [1540, 2456, 2527], 'states,': [1541], 'example,': [1543, 1841], 'myocardial': [1544], 'infarction': [1545], '(26Hayakawa': [1546], 'Takemura': [1548], 'Kanoh': [1550], 'Koda': [1554], 'Kawase': [1556], 'Maruyama': [1558], 'Okada': [1560], 'H.': [1561, 1567, 1868, 2109], 'Minatoguchi': [1562], 'Fujiwara': [1564, 1566], 'Circulation.': [1568], '108:': [1570], '104-109Crossref': [1571], '(93)': [1574], '27von': [1577], 'Harsdorf': [1578], 'Circ.': [1580], '95:': [1583], '554-556Crossref': [1584], '(21)': [1587], 'Scholar)': [1589, 1659, 2376], 'ischemic': [1591], 'renal': [1592], 'failure': [1593], '(28Melnikov': [1594], 'V.Y.': [1595], 'Faubel': [1596], 'Siegmund': [1598], 'Lucia': [1600], 'M.S.': [1601], 'Ljubanovic': [1602], 'Edelstein': [1604], 'C.L.': [1605], 'Invest.': [1608, 2990, 3085, 3307, 3810], '1083-1091Crossref': [1611], 'Scholar),': [1616, 3126, 3979], 'there': [1617, 1724, 4253], 'signaling': [1624, 1709, 1831, 2420], 'recently': [1632], '(29Gukovskaya': [1634, 3351], 'Jung': [1638, 3269, 3355, 3772], 'Mouria': [1640, 3271, 3357, 3774], '277:': [1648, 3279, 3365, 3782], '22595-22604Abstract': [1649, 3280, 3366, 3783], '"machinery"': [1663], 'present': [1665, 2398], 'isolated': [1667], 'pancreatic': [1669, 2873, 3170, 3184, 3218, 3229, 3317, 3593], 'can': [1673, 1834], 'be': [1674, 1835, 2389, 4227], 'supramaximal': [1677], 'doses': [1678, 2444], 'cholecystokinin-8': [1680], '(CCK-8),': [1681], 'cause': [1683], 'pancreatitis-like': [1684], 'changes': [1685, 4177], 'particular,': [1690, 2128], 'CCK-8': [1691, 2447, 4108], 'induced': [1692, 2438, 2685, 2802], '-3.': [1701], '-8.': [1703], 'general': [1717], 'poorly': [1718, 2046], 'understood.': [1719], 'Recent': [1720], 'findings': [1721], '(15Edinger': [1730, 2048], 'Accidental': [1780], 'unregulated': [1784], 'process': [1785], 'severe': [1788, 2217, 2526], 'stress': [1790], 'often': [1793], 'depletion': [1796], 'ATP.': [1799], 'It': [1800], 'seen': [1802], 'passive': [1805], 'explosion': [1806], 'overwhelmed': [1810], 'ion': [1812], 'fluxes.': [1813], 'so-called': [1816], 'programmed': [1817, 1821, 1919, 1935], 'necrosis-like': [1820], 'death)': [1823], 'mediated': [1825], 'coordinated': [1828], 'series': [1829], 'events': [1832], 'via': [1837], 'receptors.': [1839], 'For': [1840, 2422, 3151], 'depending': [1842], 'on': [1843, 2199, 2872, 3169, 3183, 3217, 3535, 3732, 3739], 'conditions': [1844], 'same': [1846, 2519], 'could': [1851, 2388, 4226], 'induce': [1852], 'either': [1853], '(30Kuida': [1857], 'Zheng': [1859, 1945, 2100], 'T.S.': [1860, 2101], 'Na': [1861, 2102], 'Kuan': [1863, 2104], 'Yang': [1865, 2007, 2106], 'Karasuyama': [1867, 2108], 'Rakic': [1869, 2110], 'Flavell': [1871, 2112], 'R.A.': [1872, 2113], 'Nature.': [1873, 2114], '384:': [1875, 2116], '368-372Crossref': [1876, 2117], '(1713)': [1879, 2120], '31Vercammen': [1882], 'Denecker': [1886], 'Goossens': [1888], 'Van': [1890], 'Loo': [1891], 'Grooten': [1895], 'Fiers': [1897], 'Med.': [1903], '187:': [1905], '1477-1485Crossref': [1906], '(751)': [1909], 'so': [1914], 'far': [1915], 'proven': [1916], 'kinase': [1925, 4064], '(RIP).': [1926], 'deficiency': [1928], 'rescues': [1929], 'factor-induced': [1934], '(32Chan': [1937], 'F.K.': [1938], 'Shisler': [1939], 'Bixby': [1941], 'J.G.': [1942], 'Felices': [1943], 'Appel': [1947], 'Orenstein': [1949], 'Moss': [1951], 'Lenardo': [1953], 'M.J.': [1954], '278:': [1959], '51613-51621Abstract': [1960], '(370)': [1968], '33Holler': [1971], 'N.': [1972], 'Zaru': [1973], 'Micheau': [1975], 'O.': [1976], 'Thome': [1977], 'Attinger': [1979], 'Valitutti': [1981], 'Bodmer': [1983], 'Schneider': [1985], 'Seed': [1987], 'Tschopp': [1989], 'Immunol.': [1992], '1:': [1994], '489-495Crossref': [1995], '(1467)': [1998], '34Lin': [2001], 'Choksi': [2003], 'Shen': [2005], 'H.M.': [2006], 'Q.F.': [2008], 'Hur': [2009], 'Kim': [2011], 'Y.S.': [2012], 'Tran': [2013], 'J.H.': [2014], 'Nedospasov': [2015], 'S.A.': [2016], 'Liu': [2017, 3961], 'Z.G.': [2018], '279:': [2023], '10822-10828Abstract': [2024], '(350)': [2032], 'action,': [2039], 'well': [2041, 2561], 'targets,': [2044], 'understood': [2047], '30Kuida': [2098], 'Acinar': [2123], 'recurrent': [2129], 'one': [2132, 2761], 'serious': [2136], 'complications': [2137], '35Bassi': [2162], 'Butturini': [2164], 'Falconi': [2166], 'Salvia': [2168], 'Frigerio': [2170], 'Pederzoli': [2172], '128-132Crossref': [2177], '(25)': [2180], '36Connor': [2183], 'World': [2187], '10:': [2191], '1697-1698Crossref': [2192], '(11)': [2195], 'Based': [2198], 'above-described': [2201], 'observations': [2202], 'milder': [2204], 'associated': [2210], 'more': [2212, 2220, 2525, 2653], 'forms,': [2218], 'it': [2222], 'hypothesized': [2225], 'switching': [2378], 'beneficial': [2390], 'study': [2399, 3958], 'investigated': [2401], 'explored': [2411], 'switch': [2416], 'manipulating': [2418, 2635], 'mechanisms.': [2421], 'this': [2423, 2821], 'purpose,': [2424], 'related': [2431], 'rodent': [2432], 'Pancreatitis': [2437], 'rats': [2440, 2691, 2734, 2804, 2823, 3232], 'supramaximally': [2442], 'stimulating': [2443], 'analog,': [2448], 'cerulein,': [2449], 'mild': [2452], 'form': [2453], '(7Kaiser': [2467, 2535], 'mice': [2517, 2699, 2759, 3234], 'Both': [2554], 'commonly': [2558], 'vivo': [2564], '(37Lerch': [2569], 'M.M.': [2570], 'Adler': [2571, 2583], 'Int.': [2573], 'Pancreatol.': [2575], '1994;': [2576], '15:': [2577], '159-170PubMed': [2578], '38Gorelick': [2581], 'F.S.': [2582], 'Kern': [2585], 'H.F.': [2586], 'Go': [2587], 'V.W.': [2588], 'DiMagno': [2589], 'E.P.': [2590], 'Gardner': [2591], 'J.D.': [2592], 'Lebenthal': [2593], 'E.': [2594], 'Reber': [2595], 'H.A.': [2596], 'Scheele': [2597], 'G.A.': [2598], 'Pancreas:': [2600], 'Biology,': [2601], 'Pathology,': [2602], 'Disease.': [2604], 'Raven,': [2605], 'New': [2606], 'York1993:': [2607], '64-69Google': [2608], 'drastic': [2612], 'death-signaling': [2615], 'mechanisms,': [2616], 'namely,': [2617], 'activation,': [2619], 'degradation,': [2624], 'using': [2638, 3135, 3237, 3343, 3469, 3504, 3935], 'pharmacologic': [2639], 'inhibitors,': [2640], 'able': [2643], 'shift': [2645], 'ratio,': [2648], 'making': [2649], 'like': [2654], 'each': [2655, 3174], 'other.': [2656], 'identify': [2659], 'several': [2660], 'mediators': [2662], 'represent': [2669], 'targets': [2670], 'interventions': [2673], 'attenuate': [2675], 'cell-death': [2676], 'Experimental': [2681], 'Pancreatitis—Cerulein': [2682], 'male': [2687, 2693], '(200–250': [2688], 'g)': [2689, 2695], 'Sprague-Dawley': [2690], '(25–30': [2694], 'Swiss': [2696], 'Webster': [2697], 'CD-1': [2698], 'up': [2701], 'seven': [2703], 'hourly': [2704, 2807], 'intraperitoneal': [2705, 2808], 'injections': [2706, 2715, 2809, 2817], '50': [2708, 3419], 'μg/kg': [2709], 'cerulein.': [2710], 'Control': [2711], 'animals': [2712, 2784], 'received': [2713, 2815], 'similar': [2714, 2816], 'physiologic': [2717], 'saline.': [2718, 2819], 'Q-VD-OPH': [2721], '(25': [2722], 'mg/kg)': [2723], 'Z-D-DCB': [2725], '(10': [2726], 'mg/kg),': [2727, 2752], 'vehicle': [2729, 2754], '(Me2SO),': [2730, 2755], 'applied': [2732, 2757], 'single': [2737], 'intravenous': [2738], 'injection': [2739, 2764], '30': [2740, 2773, 2788, 4021, 4200], 'min': [2741, 2774, 3434, 3567, 3578, 3694, 4022, 4201], 'before': [2742], 'start': [2744, 4204], 'treatment.': [2747], '(20': [2751], 'daily': [2762], 'subcutaneous': [2763], '5': [2766], 'consecutive': [2767], 'days;': [2768], 'started': [2772], 'after': [2775, 2795, 2828, 4202], 'last': [2777], 'injection.': [2779, 2798, 2831], 'models,': [2783], 'sacrificed': [2786, 2825], 'at': [2787, 3162, 3322, 3435, 3449, 3493, 3498, 3568, 3573, 3579, 3589, 3688, 3695, 3705, 4006, 4027, 4199, 4211, 4216, 4223, 4290], 'min,': [2789], '2,': [2790], '4,': [2791], '7': [2793, 4217, 4224], 'h': [2794, 2827, 3704, 3884, 3919, 4213, 4225], 'first': [2797, 2830], 'Arginine': [2799], '2.5': [2811], 'g/kg': [2812], 'l-arginine;': [2813], 'controls': [2814], '24': [2826], 'Animals': [2832], 'euthanized': [2834], 'CO2-induced': [2836], 'asphyxiation,': [2837], 'blood': [2840], 'pancreas': [2842, 4186, 4244], 'harvested': [2844], 'measurements.': [2846], 'Serum': [2847], 'Amylase': [2848], 'Lipase': [2850], 'Measurements—Serum': [2851], 'amylase': [2852], 'lipase': [2854], 'levels': [2855], 'measured': [2857, 3342, 4175], 'Hitachi': [2860], '707': [2861], 'analyzer': [2862], '(Antech': [2863], 'Diagnostics,': [2864], 'Irvine,': [2865], 'CA).': [2866, 4107, 4121], 'Quantification': [2867, 3176, 3208], 'Apoptosis—Apoptosis': [2869], 'quantified': [2871, 3948], 'tissue': [2874, 3127, 3171, 3185, 3219, 3404, 3532, 3614, 3633, 3734, 3986], 'sections': [2875, 3013, 3034, 3128, 3172, 3186, 3220], 'stained': [2876, 3036, 3130, 3187, 3221], 'Hoechst': [2878, 3040], '33258': [2879, 3041], 'visualize': [2881], 'nuclear': [2882], 'morphology': [2884], 'TUNEL': [2887, 3095], 'assay': [2888, 3096, 3346, 3540, 3606, 3624], 'measure': [2890], 'breaks,': [2892], 'described': [2895, 3244, 3349, 3611, 3747], 'previously': [2896, 3245, 3350, 3748], '(3Gukovsky': [2897, 3246, 3749], '6Gukovskaya': [2916], '39Gukovskaya': [2974, 3069, 3291, 3794], 'Song': [2980, 3075, 3297, 3800], '1997;': [2991, 3086, 3308, 3811], '100:': [2992, 3087, 3309, 3812], '1853-1862Crossref': [2993, 3088, 3310, 3813], '(344)': [2996, 3091, 3313, 3816], 'Tissue': [2999, 3522], 'fixed': [3001], '4%': [3003], 'buffered': [3004], 'formaldehyde': [3005], 'embedded': [3007], 'paraffin,': [3009], '6': [3011], 'μm-thick': [3012], 'adhered': [3015], 'glass': [3017, 3678], 'slides.': [3018], 'Sections': [3019], 'deparaffinized': [3021], 'washing': [3023], 'Hemo-De': [3025], 'hydrated': [3027], 'transferring': [3029], 'graded': [3031], 'ethanol.': [3032], '8': [3038, 3997], 'μg/ml': [3039, 3561], 'examined': [3043], 'fluorescence': [3045], 'microscopy.': [3046], 'Nuclei': [3047, 3683], 'condensed': [3049], 'fragmented': [3051], 'considered': [3054, 3206], '(12Gukovskaya': [3056], 'breaks': [3132], 'transferase': [3138], 'fluorescein': [3140], 'isothiocyanate-labeled': [3141], 'according': [3143, 3954], "manufacturer's": [3146], 'protocol': [3147], '(Promega,': [3148], 'Madison,': [3149], 'WI).': [3150], 'quantifications': [3155], 'histologic': [3157], 'measurements,': [3158], 'total': [3160, 3733], 'least': [3163], '1000': [3164], 'counted': [3168], 'animal.': [3175], 'Necrosis—Quantification': [3178], 'performed': [3182, 3216, 3236, 3731], 'H&E.': [3189, 3223], 'Cells': [3190], 'swollen': [3192], 'cytoplasm,': [3193], 'loss': [3194], 'membrane': [3197, 3714, 3741], 'integrity,': [3198], 'leakage': [3200], 'into': [3203], 'interstitium': [3204], 'necrotic.': [3207], 'Inflammatory': [3210], 'Infiltration—Quantification': [3211], 'Isolation': [3224], 'Pancreatic': [3226, 3403], 'Acini—Isolation': [3227], 'acini': [3230, 3318, 3594], 'collagenase': [3239], 'digestion': [3240], 'procedure': [3241], '29Gukovskaya': [3265, 3768], 'Dispersed': [3316, 3592], 'then': [3320, 3880, 4036], 'incubated': [3321, 3881, 3916, 4005], '37': [3323, 3450, 4007], '°C': [3324, 3451, 3575, 4008], '199': [3326], 'medium': [3327], '(Invitrogen)': [3328], 'presence': [3331], 'absence': [3333], '100': [3335], 'nm': [3336, 3495], 'CCK-8.': [3337], 'Activities—Caspase': [3339], 'activities': [3340], 'fluorogenic': [3345, 4123], '40Vaquero': [3377, 3819], 'E.C.': [3378, 3820], 'Edderkaoui': [3379, 3821], 'Nam': [3381, 3823], '125:': [3391, 3833], '1188-1202Abstract': [3392, 3834], '(69)': [3400, 3842], 'samples': [3408, 3637, 4034], 'homogenized': [3410, 3534, 3639], 'lysis': [3413], 'buffer': [3414, 3454, 3541, 3642, 3893], 'containing': [3415, 3455, 3553, 3643, 3894, 3996], '150': [3416], 'mm': [3417, 3420, 3429, 3457, 3467, 3545, 3645, 3648, 3653, 3656, 3659, 3662, 3665, 3668], 'NaCl,': [3418], 'Tris-HCl': [3421, 3993], '(pH': [3422, 3459, 3650, 3875, 3994], '7.5),': [3423, 3460], '0.5%': [3424], 'Igepal': [3425], 'CA-630,': [3426], '0.5': [3428], 'EDTA,': [3430, 3663], 'centrifuged': [3431, 3572, 3701], '15': [3433, 3577], '16,000': [3436, 3580], '×': [3437, 3581, 3690, 3707], 'g,': [3438, 3708], 'supernatants': [3441, 3584], 'collected.': [3443], 'Proteolytic': [3444], 'reactions': [3445], 'carried': [3447], 'out': [3448], '25': [3456], 'HEPES': [3458], '10%': [3461], 'sucrose,': [3462, 3646], '0.1%': [3463], '10': [3466, 3652, 3693], 'dithiothreitol,': [3468, 3666, 4003], 'substrates': [3470, 3483, 4124], 'caspase-3': [3473], '(Ac-DEVD-AMC),': [3474], '(Ac-IETD-AMC),': [3476], '(Ac-LEHD-AMC).': [3479], 'Cleavage': [3480], 'relieves': [3484], '7-amino-4-methylcoumarin': [3485], '(AMC),': [3486], 'emits': [3488], 'fluorescent': [3489], 'signal': [3490], 'excitation': [3492], '380': [3494], 'emission': [3497], '440': [3499], 'nm.': [3500], 'Fluorescence': [3501], 'calibrated': [3503], 'standard': [3506], 'curve': [3507], 'AMC.': [3509], 'data': [3511], 'expressed': [3513], 'moles': [3515], 'AMC/mg': [3517], 'protein/min.': [3519], 'Preparation': [3520, 3627], 'Lysates': [3525], 'Western': [3527, 3726, 3728, 4047], 'Blot': [3528, 3729], 'Analysis—Portions': [3529], 'frozen': [3531], 'ice': [3536], 'radioimmune': [3538, 3604], 'precipitation': [3539, 3605], 'supplemented': [3542], '1': [3544, 3655, 3661, 3664, 3667, 3703, 3918, 4010], 'phenylmethylsulfonyl': [3546, 3669], 'fluoride': [3547], 'protease': [3550, 3673], 'mixture': [3552, 3675], 'pepstatin,': [3554], 'leupeptin,': [3555], 'chymostatin,': [3556], 'antipain,': [3557], 'aprotinin': [3559], '(5': [3560], 'each),': [3563], 'rotated': [3564], '20': [3566, 3647, 3905], '4': [3569, 3574, 3696, 4212, 4291], '°C,': [3570], 'g.': [3582], 'collected': [3586, 3721], 'stored': [3588], '–80': [3590], '°C.': [3591, 3697], 'washed': [3596, 3909], 'twice': [3597], 'ice-cold': [3599], 'phosphate-buffered': [3600], 'saline,': [3601], 'resuspended': [3602], 'buffer,': [3607], 'processed': [3609], 'above': [3612], 'samples.': [3615], 'Protein': [3616], 'concentrations': [3617], 'determined': [3619], 'Bio-Rad': [3622], '(Bio-Rad': [3625], 'Laboratories).': [3626], 'Membrane': [3629], 'Cytosolic': [3631], 'Fractions—Pancreatic': [3632], '250': [3644], 'HEPES-KOH': [3649], '7.0),': [3651], 'KCl,': [3654], 'EGTA,': [3657], '2': [3658, 3883], 'MgCl2,': [3660], 'fluoride,': [3670], 'Dounce': [3679], 'homogenizer': [3680], '(80': [3681], 'strokes).': [3682], 'removed': [3685], 'centrifugation': [3687], '1,000': [3689], 'g': [3691], 'supernatant': [3699, 3717], '100,000': [3706], 'pellet': [3712], '(mitochondria-enriched': [3713], 'fraction)': [3715, 3719], '(cytosolic': [3718], 'separately': [3722], 'blotting.': [3727], 'Analysis—was': [3730], 'lysates,': [3737], 'cytosolic': [3743], 'fractions,': [3744], 'Proteins': [3845], 'separated': [3847, 4037], 'SDS-PAGE': [3849], 'electrophoretically': [3851], 'transferred': [3852, 4040], 'nitrocellulose': [3854, 4042], 'membranes.': [3855], 'Nonspecific': [3856], 'binding': [3857], 'blocked': [3859], '1-h': [3861], 'incubation': [3862, 4019], 'membranes': [3865], '5%': [3867], '(w/v)': [3868, 3896], 'nonfat': [3869, 3897], 'dry': [3870, 3898], 'milk': [3871, 3899], 'Tris-buffered': [3873, 3907], 'saline': [3874], '7.5).': [3876], 'blots': [3878, 3930], 'overnight': [3886], 'primary': [3888], 'antibodies': [3889], 'antibody': [3892, 3924, 3927, 4051], '1%': [3895], 'TTBS': [3901], '(0.05%': [3902], '(v/v)': [3903], 'Tween': [3904], 'saline),': [3908], 'three': [3910], 'times': [3911], 'TTBS,': [3913], 'finally': [3915], 'peroxidase-labeled': [3922], 'secondary': [3923], 'buffer.': [3928], 'developed': [3932], 'visualization': [3934], 'enhanced': [3936], 'chemiluminescence': [3937], '(ECL)': [3938], 'detection': [3939], 'kit': [3940], '(Pierce).': [3941], 'Band': [3942], 'intensities': [3943], 'immunoblots': [3946], 'densitometry.': [3950], 'Reduction/Alkylation—This': [3951], 'done': [3953], 'previous': [3957], '(41Soares': [3959], 'R.V.': [3960], 'Oppenheim': [3963], 'F.G.': [3964], 'Offner': [3965], 'G.D.': [3966], 'Troxler': [3967], 'R.F.': [3968], 'Arch.': [3969], 'Oral': [3970], '47:': [3973], '591-597Crossref': [3974], '(7)': [3977], 'minor': [3981], 'modifications.': [3982], 'Briefly,': [3983], 'lysate': [3987], 'reduced': [3989, 4014], '0.1': [3991, 4001], 'm': [3992, 3998, 4002, 4025], '9.0)': [3995], 'urea': [3999], 'h.': [4011, 4218], 'Alkylation': [4012], '0.3': [4024], 'iodoacetamide': [4026], 'room': [4028], 'temperature': [4029], 'dark.': [4032], 'SDS-PAGE,': [4039], 'membranes,': [4043], 'subjected': [4045], 'blot': [4048], 'analysis': [4049], 'against': [4052, 4058], 'Antibodies': [4055], 'Reagents—Antibodies': [4057], 'p44/42': [4061], 'mitogen-activate': [4062], '(Erk1/2)': [4065], 'Signaling': [4069], '(Beverly,': [4070], 'MA);': [4071], 'caspase-3,': [4072], 'caspase-8,': [4073], 'FLIPS/L,': [4075], 'Santa': [4077], 'Cruz': [4078], 'Biotechnology': [4079], '(Santa': [4080], 'Cruz,': [4081], 'CA);': [4082, 4093, 4114], 'c,': [4084], 'Pyk2,': [4087], 'BD': [4089], 'Biosciences': [4090], '(San': [4091, 4105, 4153], 'Diego,': [4092, 4106, 4154], 'COX': [4094], 'IV,': [4095], 'Molecular': [4097], 'Probes': [4098], '(Eugene,': [4099], 'OR);': [4100], 'caspase-9,': [4102], 'Stressgen': [4104], 'American': [4111], 'Peptide': [4112], '(Sunnyvale,': [4113], 'Peninsula': [4118], 'Laboratories': [4119], '(Belmont,': [4120], 'Ac-IETD-AMC,': [4125], 'Ac-DEVD-AMC,': [4126], 'Ac-LEHD-AMC,': [4128], '(2,5-dihydroxy-3-undecyl-1,4-benzoquinone)': [4134], 'Biomol': [4137], '(Plymouth': [4138], 'Meeting,': [4139], 'PA).': [4140], 'Z-Asp-2,6-dichlorobenzoyloxymethylketone': [4143], '(Z-D-DCB)': [4144], 'Q-Val': [4146], '-Asp(non-O-methylated)-OPh': [4147], '(Q-VD-OPH)': [4148], 'ALEXIS': [4151], 'Biochemicals': [4152], 'CA)': [4155], 'Enzyme': [4157], 'Systems': [4158], 'Products': [4159], '(Livermore,': [4160], 'CA),': [4161], 'respectively.': [4162], 'Other': [4163], 'reagents': [4164], 'Sigma.': [4167], 'time-dependent': [4176], '(Fig.': [4187], '1).': [4188], 'unchanged': [4198], 'increased': [4209, 4231, 4272], '∼33-fold': [4210], '∼16-fold': [4215], 'decrease': [4220], 'due': [4228], 'clearance': [4232], 'cells,': [4238], 'number': [4240], 'increases': [4245], 'time.': [4247], 'Compared': [4248], 'much': [4255], 'less': [4256], 'increase': [4264, 4284], 'minimal.': [4268], 'Necrosis': [4269], 'time': [4270], 'dependently': [4271], 'detected': [4289]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2055388969', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 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