Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2054549100', 'doi': 'https://doi.org/10.1007/s00228-007-0348-7', 'title': 'Gender-associated differences in pharmacokinetics and anti-arrhythmic effects of flecainide in Japanese patients with supraventricular tachyarrhythmia', 'display_name': 'Gender-associated differences in pharmacokinetics and anti-arrhythmic effects of flecainide in Japanese patients with supraventricular tachyarrhythmia', 'publication_year': 2007, 'publication_date': '2007-07-31', 'ids': {'openalex': 'https://openalex.org/W2054549100', 'doi': 'https://doi.org/10.1007/s00228-007-0348-7', 'mag': '2054549100', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17665182'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s00228-007-0348-7', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S31780008', 'display_name': 'European Journal of Clinical Pharmacology', 'issn_l': '0031-6970', 'issn': ['0031-6970', '1432-1041'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5031741885', 'display_name': 'Kosuke Doki', 'orcid': 'https://orcid.org/0000-0003-2497-0063'}, 'institutions': [{'id': 'https://openalex.org/I146399215', 'display_name': 'University of Tsukuba', 'ror': 'https://ror.org/02956yf07', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146399215']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kosuke Doki', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.', 'institution_ids': ['https://openalex.org/I146399215']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084498942', 'display_name': 'Masato Homma', 'orcid': 'https://orcid.org/0000-0002-4824-3242'}, 'institutions': [{'id': 'https://openalex.org/I146399215', 'display_name': 'University of Tsukuba', 'ror': 'https://ror.org/02956yf07', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146399215']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masato Homma', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.', 'institution_ids': ['https://openalex.org/I146399215']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041735171', 'display_name': 'Keisuke Kuga', 'orcid': 'https://orcid.org/0000-0001-6318-2866'}, 'institutions': [{'id': 'https://openalex.org/I146399215', 'display_name': 'University of Tsukuba', 'ror': 'https://ror.org/02956yf07', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146399215']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Keisuke Kuga', 'raw_affiliation_strings': ['Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.', 'institution_ids': ['https://openalex.org/I146399215']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078388970', 'display_name': 'Kazutaka Aonuma', 'orcid': 'https://orcid.org/0000-0002-2332-111X'}, 'institutions': [{'id': 'https://openalex.org/I146399215', 'display_name': 'University of Tsukuba', 'ror': 'https://ror.org/02956yf07', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146399215']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazutaka Aonuma', 'raw_affiliation_strings': ['Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.', 'institution_ids': ['https://openalex.org/I146399215']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048935550', 'display_name': 'Satoshi Sakai', 'orcid': 'https://orcid.org/0000-0002-0056-1014'}, 'institutions': [{'id': 'https://openalex.org/I146399215', 'display_name': 'University of Tsukuba', 'ror': 'https://ror.org/02956yf07', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146399215']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Satoshi Sakai', 'raw_affiliation_strings': ['Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.', 'institution_ids': ['https://openalex.org/I146399215']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013893275', 'display_name': 'Iwao Yamaguchi', 'orcid': 'https://orcid.org/0000-0003-2370-031X'}, 'institutions': [{'id': 'https://openalex.org/I146399215', 'display_name': 'University of Tsukuba', 'ror': 'https://ror.org/02956yf07', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146399215']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Iwao Yamaguchi', 'raw_affiliation_strings': ['Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Internal Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.', 'institution_ids': ['https://openalex.org/I146399215']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5072105975', 'display_name': 'Yukinao Kohda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I146399215', 'display_name': 'University of Tsukuba', 'ror': 'https://ror.org/02956yf07', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I146399215']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yukinao Kohda', 'raw_affiliation_strings': ['Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.', 'institution_ids': ['https://openalex.org/I146399215']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3390, 'currency': 'EUR', 'value_usd': 4390, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.688, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 15, 'citation_normalized_percentile': {'value': 0.736255, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 86, 'max': 87}, 'biblio': {'volume': '63', 'issue': '10', 'first_page': '951', 'last_page': '957'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10217', 'display_name': 'Molecular Mechanisms of Cardiac Arrhythmias', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10217', 'display_name': 'Molecular Mechanisms of Cardiac Arrhythmias', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11460', 'display_name': 'Green Analytical Chemistry in Pharmaceutical Analysis', 'score': 0.9708, 'subfield': {'id': 'https://openalex.org/subfields/1602', 'display_name': 'Analytical Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T12418', 'display_name': 'Diagnosis and Management of Chronic Cough', 'score': 0.9688, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/flecainide', 'display_name': 'Flecainide', 'score': 0.9955846}, {'id': 'https://openalex.org/keywords/arrhythmias', 'display_name': 'Arrhythmias', 'score': 0.476295}], 'concepts': [{'id': 'https://openalex.org/C2779837460', 'wikidata': 'https://www.wikidata.org/wiki/Q421381', 'display_name': 'Flecainide', 'level': 3, 'score': 0.9955846}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.8122683}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.78124845}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5320759}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.4022447}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.39871895}, {'id': 'https://openalex.org/C2779161974', 'wikidata': 'https://www.wikidata.org/wiki/Q815819', 'display_name': 'Atrial fibrillation', 'level': 2, 'score': 0.1620464}], 'mesh': [{'descriptor_ui': 'D000889', 'descriptor_name': 'Anti-Arrhythmia Agents', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000889', 'descriptor_name': 'Anti-Arrhythmia Agents', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D044466', 'descriptor_name': 'Asians', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005424', 'descriptor_name': 'Flecainide', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D005424', 'descriptor_name': 'Flecainide', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D013617', 'descriptor_name': 'Tachycardia, Supraventricular', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000889', 'descriptor_name': 'Anti-Arrhythmia Agents', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D000889', 'descriptor_name': 'Anti-Arrhythmia Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002851', 'descriptor_name': 'Chromatography, High Pressure Liquid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003430', 'descriptor_name': 'Cross-Sectional Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019389', 'descriptor_name': 'Cytochrome P-450 CYP2D6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019389', 'descriptor_name': 'Cytochrome P-450 CYP2D6', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019389', 'descriptor_name': 'Cytochrome P-450 CYP2D6', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015716', 'descriptor_name': 'Electrocardiography, Ambulatory', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005424', 'descriptor_name': 'Flecainide', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D005424', 'descriptor_name': 'Flecainide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005838', 'descriptor_name': 'Genotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006239', 'descriptor_name': 'Haplotypes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007564', 'descriptor_name': 'Japan', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009124', 'descriptor_name': 'Muscle Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D062554', 'descriptor_name': 'NAV1.5 Voltage-Gated Sodium Channel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012737', 'descriptor_name': 'Sex Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015222', 'descriptor_name': 'Sodium Channels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015222', 'descriptor_name': 'Sodium Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015222', 'descriptor_name': 'Sodium Channels', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013617', 'descriptor_name': 'Tachycardia, Supraventricular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013617', 'descriptor_name': 'Tachycardia, Supraventricular', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013617', 'descriptor_name': 'Tachycardia, Supraventricular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013617', 'descriptor_name': 'Tachycardia, Supraventricular', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/s00228-007-0348-7', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S31780008', 'display_name': 'European Journal of Clinical Pharmacology', 'issn_l': '0031-6970', 'issn': ['0031-6970', '1432-1041'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17665182', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.64}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 23, 'referenced_works': ['https://openalex.org/W1535792572', 'https://openalex.org/W1967231443', 'https://openalex.org/W1978599196', 'https://openalex.org/W1981464546', 'https://openalex.org/W1985597417', 'https://openalex.org/W1986868017', 'https://openalex.org/W1999173998', 'https://openalex.org/W2002374666', 'https://openalex.org/W2007566862', 'https://openalex.org/W2008637373', 'https://openalex.org/W2019954105', 'https://openalex.org/W2023778178', 'https://openalex.org/W2024977696', 'https://openalex.org/W2025203994', 'https://openalex.org/W2045132297', 'https://openalex.org/W2049976899', 'https://openalex.org/W2055983308', 'https://openalex.org/W2065451737', 'https://openalex.org/W2081800681', 'https://openalex.org/W2095131571', 'https://openalex.org/W2126236636', 'https://openalex.org/W2145542533', 'https://openalex.org/W2156298906'], 'related_works': ['https://openalex.org/W4387497383', 'https://openalex.org/W3183948672', 'https://openalex.org/W3173606202', 'https://openalex.org/W3110381201', 'https://openalex.org/W2948807893', 'https://openalex.org/W2935909890', 'https://openalex.org/W2778153218', 'https://openalex.org/W2758277628', 'https://openalex.org/W1941767368', 'https://openalex.org/W1531601525'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2054549100', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-08-15T07:14:58.280337', 'created_date': '2016-06-24'}