Publication Information

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'https://openalex.org/W2298656647', 'https://openalex.org/W2049868369', 'https://openalex.org/W2044917002', 'https://openalex.org/W2038275607', 'https://openalex.org/W2020080372', 'https://openalex.org/W1995895091', 'https://openalex.org/W1992868516', 'https://openalex.org/W1510038452'], 'abstract_inverted_index': {'We': [0, 257, 1437], 'previously': [1, 258, 1438, 1686, 1813, 1856, 2646, 3359, 4287], 'identified': [2, 259, 2149], 'a': [3, 58, 106, 195, 220, 236, 260, 315, 363, 452, 477, 493, 661, 768, 920, 1086, 1408, 1505, 1586, 1616, 1624, 1648, 2132, 2166, 2252, 2267, 2276, 2293, 2341, 2388, 2593, 2829, 2981, 3075, 3144, 3194, 3228, 3327, 3736, 3845, 3882, 3925, 4120], 'mammalian': [4, 261, 626, 925, 1069, 1078, 1500, 3403], 'Set1A': [5, 34, 70, 117, 131, 140, 165, 189, 199, 214, 230, 262, 291, 327, 374, 388, 397, 422, 446, 456, 471, 487, 1597, 1653, 1883, 2382, 2609, 2753, 2926, 2946, 2976, 2995, 3043, 3107, 3364, 3414, 3618, 3664, 3679, 3692, 3727, 3787, 3832, 3873, 3886, 3939, 4180, 4268, 4351], 'complex': [6, 15, 61, 104, 263, 272, 318, 361, 663, 1520, 1533, 1574, 1625, 1649, 1654, 3365, 3372, 3887, 3970, 4290], 'analogous': [7, 264, 1525, 3367], 'to': [8, 184, 219, 235, 247, 265, 441, 476, 492, 504, 620, 754, 1013, 1022, 1094, 1291, 1364, 1426, 1523, 1526, 1594, 1607, 1627, 1630, 1994, 2108, 2131, 2165, 2220, 2580, 2739, 2903, 2935, 2965, 3098, 3139, 3158, 3357, 3368, 3408, 3659, 3673, 3858, 3868, 3912, 4089, 4119, 4175, 4225, 4315, 4342, 4349], 'the': [9, 69, 90, 93, 102, 126, 148, 151, 155, 164, 207, 248, 266, 326, 347, 350, 359, 383, 405, 408, 412, 421, 464, 505, 615, 652, 749, 1014, 1023, 1063, 1066, 1090, 1103, 1106, 1285, 1353, 1416, 1423, 1499, 1508, 1517, 1527, 1538, 1595, 1602, 1652, 1657, 1660, 1750, 1846, 1887, 1894, 1917, 1966, 2010, 2073, 2189, 2305, 2313, 2569, 2772, 2793, 2860, 2915, 2945, 2956, 2975, 2986, 3150, 3168, 3340, 3347, 3362, 3369, 3395, 3409, 3620, 3703, 3718, 3722, 3754, 3837, 3850, 3860, 3863, 3872, 3885, 3954, 3959, 3968, 4033, 4111, 4138, 4179, 4203, 4206, 4216, 4254, 4280, 4286, 4322, 4334, 4338, 4343], 'yeast': [10, 267, 648, 654, 917, 1015, 1503, 1528, 3370, 3410, 3610, 3674], 'Set1/COMPASS': [11, 268, 1509], 'histone': [12, 95, 107, 112, 269, 352, 364, 369, 517, 608, 627, 630, 640, 655, 762, 922, 930, 971, 1070, 1108, 1355, 1404, 1510, 1576, 1618, 1666, 2705, 3397, 3846], 'H3-Lys4': [13, 270, 656, 763, 923, 972, 1071, 1109, 1356, 1405, 1511, 1577, 3398], 'methyltransferase': [14, 108, 208, 271, 365, 465, 657, 1110, 1357, 1406, 1433, 1512, 1578, 1667, 2640, 2716, 2733, 3399], '(Lee,': [16, 273], 'J.-H.,': [17, 274], 'and': [18, 50, 77, 118, 141, 176, 190, 200, 215, 231, 242, 254, 275, 307, 334, 375, 398, 433, 447, 457, 472, 488, 499, 511, 523, 533, 613, 637, 658, 758, 979, 1350, 1422, 1546, 1629, 1663, 1672, 1683, 1708, 1736, 1766, 1786, 1790, 1799, 1810, 1840, 1889, 1969, 2016, 2082, 2087, 2100, 2106, 2135, 2154, 2188, 2205, 2227, 2249, 2263, 2300, 2328, 2362, 2376, 2397, 2412, 2435, 2458, 2468, 2472, 2513, 2518, 2520, 2527, 2558, 2566, 2578, 2589, 2610, 2618, 2626, 2729, 2743, 2754, 2768, 2778, 2783, 2812, 2845, 2848, 2892, 2907, 2927, 2952, 2993, 2996, 3005, 3017, 3022, 3029, 3034, 3036, 3040, 3044, 3063, 3078, 3113, 3180, 3197, 3211, 3237, 3245, 3252, 3272, 3284, 3294, 3324, 3556, 3619, 3665, 3670, 3677, 3680, 3686, 3693, 3699, 3706, 3714, 3732, 3742, 3745, 3833, 3867, 3910, 3922, 3929, 3938, 3946, 3973, 4078, 4099, 4117, 4126, 4142, 4167, 4195, 4236], 'Skalnik,': [19, 276], 'D.': [20, 277, 723, 832, 1182, 1223, 3765], 'G.': [21, 278, 1158], '(2005)': [22, 279], 'J.': [23, 280, 671, 700, 736, 780, 809, 845, 857, 861, 863, 939, 984, 1123, 1297, 1555, 1692, 1862, 2027, 2651, 3377, 3416, 3442, 3627, 3778, 3801, 3892, 3980, 4295], 'Biol.': [24, 281, 556, 595, 1387, 1490, 1556, 1693, 1863, 2028, 2652, 3378, 3455, 3547, 3596, 3893, 3993, 4021, 4296], 'Chem.': [25, 282, 1557, 1694, 1864, 2029, 2653, 3379, 3894, 4297], '280,': [26, 283], '41725–41731).': [27, 284], 'Data': [28, 285, 1582, 3605], 'base': [29, 286, 1583, 2318, 3606], 'analysis': [30, 287, 1584, 2153, 2632, 3607, 4261, 4275], 'indicates': [31, 288, 3608, 4329], 'that': [32, 54, 62, 86, 101, 109, 213, 229, 289, 311, 319, 343, 358, 366, 470, 486, 529, 932, 1399, 1590, 1644, 1664, 1747, 1849, 1978, 2833, 2923, 3361, 3609, 3752, 3794, 3841, 4032, 4148, 4330], 'human': [33, 83, 290, 340, 1018, 1463, 1518, 1535, 1572, 1588, 1596, 1834, 1882, 1908, 2315, 2369, 2704, 2992, 3019, 3024, 3363, 3617, 3678], 'protein': [35, 84, 179, 292, 341, 436, 650, 1442, 1589, 1996, 2316, 2549, 3623, 3961, 3965, 4132, 4163], 'shares': [36, 293], '39%': [37, 294, 3684], 'identity': [38, 91, 295, 348, 1658, 3672, 3685], 'with': [39, 57, 172, 206, 296, 314, 429, 463, 635, 645, 660, 1623, 1647, 1731, 1761, 1986, 2048, 2072, 2177, 2214, 2239, 2266, 2292, 2404, 2419, 2500, 2509, 2560, 2914, 2939, 2969, 3167, 3205, 3214, 3262, 3298, 3310, 3315, 3326, 3616, 3796, 3871, 3919, 3944, 3963, 4041, 4073, 4137, 4156, 4333], 'an': [40, 297, 1851, 1900, 1937, 2118, 2194, 2283, 3127, 3749, 3790, 4055], 'uncharacterized': [41, 298, 3621], 'SET': [42, 166, 299, 423, 611, 3705, 3723, 3838, 3956], 'domain': [43, 167, 180, 300, 424, 437, 3724, 3758, 3957], 'protein,': [44, 143, 301, 400, 1017, 1612, 3412], 'KIAA1076,': [45, 302, 3435], 'hereafter': [46, 303], 'denoted': [47, 304, 664, 1549, 1613], 'Set1B.': [48, 305, 3662], 'Immunoprecipitation': [49, 306, 2396], 'mass': [51, 308, 2297, 4170], 'spectrometry': [52, 309], 'reveal': [53, 81, 310, 338], 'Set1B': [55, 103, 119, 133, 142, 191, 201, 216, 232, 312, 360, 376, 390, 399, 448, 458, 473, 489, 1645, 1909, 1967, 2147, 2755, 2928, 2957, 2987, 2997, 3045, 3114, 3666, 3681, 3694, 3821, 3842, 3851, 3865, 3937, 4039, 4051, 4140, 4208, 4270, 4326, 4339, 4347], 'associates': [56, 313, 659, 1622, 1646], '∼450': [59, 316, 3949], 'kDa': [60, 317, 2199, 3950], 'contains': [63, 320, 1534, 3789], 'all': [64, 321, 1945, 4283], 'five': [65, 322], 'non-catalytic': [66, 152, 323, 409], 'components': [67, 153, 324, 410, 3966, 4042, 4177], 'of': [68, 92, 125, 129, 137, 150, 154, 163, 188, 197, 224, 239, 251, 325, 349, 382, 386, 394, 407, 411, 420, 445, 454, 481, 496, 508, 516, 535, 607, 617, 625, 639, 761, 771, 970, 1025, 1065, 1068, 1085, 1089, 1284, 1352, 1366, 1402, 1410, 1418, 1431, 1502, 1507, 1516, 1537, 1601, 1659, 1881, 1907, 1944, 1956, 1965, 1971, 1989, 2051, 2169, 2180, 2279, 2322, 2484, 2693, 2702, 2752, 2774, 2837, 2843, 2851, 2955, 3101, 3318, 3351, 3721, 3849, 3862, 3884, 3958, 3967, 4038, 4043, 4050, 4123, 4178, 4205, 4219, 4266, 4276, 4282, 4285, 4325, 4337, 4345], 'complex,': [71, 328, 1540, 3866, 4181, 4209], 'including': [72, 329, 519, 1541, 3413, 4182, 4311], 'CFP1,': [73, 173, 330, 430, 1836, 4233], 'Rbbp5,': [74, 175, 331, 432, 1545, 1838, 3972, 4235], 'Ash2,': [75, 174, 332, 431, 1544, 1837, 4234], 'Wdr5,': [76, 333, 1543, 1839], 'Wdr82.': [78, 335, 4312], 'These': [79, 336, 4172], 'data': [80, 337, 1641, 2301, 2317], 'two': [82, 339, 1637, 3095], 'complexes': [85, 342, 1668], 'differ': [87, 344], 'only': [88, 345, 919], 'in': [89, 346, 1114, 1580, 1713, 1725, 1755, 1781, 1792, 2304, 2333, 2373, 2523, 2540, 2601, 2828, 2856, 3048, 3094, 3193, 3209, 3218, 3227, 3279, 3302, 3400, 3735, 3798, 4062, 4146, 4247, 4318], 'catalytic': [94, 351, 1661, 3704], 'methyltransferase.': [96, 353, 3847], 'In': [97, 354], 'vitro': [98, 355], 'assays': [99, 356, 2641, 3073], 'demonstrate': [100, 357], 'is': [105, 168, 181, 194, 362, 425, 438, 451, 633, 643, 651, 746, 1020, 1397, 1407, 1615, 3366, 3394, 3612], 'produces': [110, 367, 2980], 'trimethylated': [111, 368], 'H3': [113, 370, 2474, 2706], 'at': [114, 371, 764, 2110, 2246, 2275, 2816, 2866, 2876, 2896, 3188, 3339, 3346, 3948], 'Lys4.': [115, 372], 'Both': [116, 373], 'are': [120, 377, 1111, 1434, 1960, 3696], 'widely': [121, 378, 1075], 'expressed.': [122, 379], 'Inducible': [123, 380], 'expression': [124, 149, 381, 406, 537, 2014, 3047, 3072, 3162, 4158, 4256], 'carboxyl': [127, 384, 4036, 4217, 4323], 'terminus': [128, 385, 4037, 4218], 'either': [130, 387], 'or': [132, 389, 1096, 1287, 2012, 2218, 2493, 2699, 4269], 'decreases': [134, 391], 'steady-state': [135, 392], 'levels': [136, 393], 'both': [138, 395, 1670, 2607, 2925, 3942], 'endogenous': [139, 396, 2608, 3128, 4267], 'but': [144, 401, 1415, 2949, 2979, 3820, 4243], 'does': [145, 402, 2942, 2972], 'not': [146, 204, 403, 461, 2943, 2973, 4144, 4245], 'alter': [147, 404], 'Set1': [156, 413, 649, 745, 1016, 3411, 3611, 4289], 'complexes.': [157, 414], 'A': [158, 415, 604, 1058, 1741, 1904], '123-amino': [159, 416], 'acid': [160, 417, 1926, 2242], 'fragment': [161, 418, 2344, 2349, 2354, 2359, 2365, 2391, 2495, 2612, 4114, 4348], 'upstream': [162, 419, 3720], 'necessary': [169, 426], 'for': [170, 427, 1656, 1991, 2018, 2114, 2146, 2229, 2243, 2409, 2502, 2529, 2537, 2568, 2715, 2819, 2869, 2879, 2884, 2889, 3003, 3106, 3163, 3199, 3224, 3254, 3286, 3304, 3343, 4075, 4110], 'interaction': [171, 428], 'Wdr5.': [177, 434], 'This': [178, 435], 'also': [182, 439, 2384], 'required': [183, 440], 'mediate': [185, 442], 'feedback': [186, 443], 'inhibition': [187, 444], 'expression,': [192, 449], 'which': [193, 450, 632, 642, 1898, 1935, 2941, 2971, 3171, 3393], 'consequence': [196, 453], 'reduced': [198, 455], 'stability': [202, 459], 'when': [203, 460], 'associated': [205, 462, 634, 644, 4136], 'complex.': [209, 466, 1513, 1530, 3874, 4046], 'Confocal': [210, 467, 3181, 3335], 'microscopy': [211, 468, 3336], 'reveals': [212, 469, 1585, 4279], 'each': [217, 233, 474, 490, 1403, 1432, 2838, 3164], 'localize': [218, 475], 'largely': [221, 478, 1435], 'non-overlapping': [222, 479], 'set': [223, 238, 480, 495, 3077], 'euchromatic': [225, 482], 'nuclear': [226, 483, 4079, 4210], 'speckles,': [227, 484], 'suggesting': [228, 485], 'bind': [234, 491], 'unique': [237, 494, 1428], 'target': [240, 497, 1412], 'genes': [241, 498, 1028, 1289], 'thus': [243, 500], 'make': [244, 501], 'non-redundant': [245, 502, 1081, 1400, 1673], 'contributions': [246, 503], 'epigenetic': [249, 506, 527], 'control': [250, 507], 'chromatin': [252, 509, 531], 'structure': [253, 510, 532], 'gene': [255, 512, 536, 1104, 1413, 1420, 3046, 3071, 3161, 3165], 'expression.': [256, 513, 1997], 'Covalent': [514], 'modification': [515], 'proteins,': [518, 4069], 'methylation,': [520], 'acetylation,': [521], 'ubiquitination,': [522], 'phosphorylation,': [524], 'confers': [525], 'critical': [526], 'information': [528], 'controls': [530, 3002], 'regulation': [534], '(1Shilatifard': [538], 'A.': [539, 681, 688, 711, 721, 725, 790, 797, 820, 830, 834, 859, 871, 877, 1049, 1138, 1201, 1234, 1273, 1485, 2681, 3438, 3482, 3763, 3767, 3976], 'Annu.': [540, 576], 'Rev.': [541, 577, 592], 'Biochem.': [542, 578], '2006;': [543, 959, 1004, 1317, 3647, 4022], '75:': [544], '243-269Crossref': [545], 'PubMed': [546, 565, 582, 599, 692, 715, 740, 801, 824, 849, 888, 911, 962, 1007, 1053, 1142, 1170, 1205, 1238, 1256, 1277, 1320, 1345, 1391, 1494, 1566, 1703, 1825, 1873, 2038, 2662, 2685, 3388, 3430, 3459, 3503, 3551, 3600, 3650, 3782, 3815, 3903, 3997, 4025, 4306], 'Scopus': [547, 566, 583, 600, 693, 716, 741, 802, 825, 850, 889, 912, 963, 1008, 1054, 1143, 1171, 1206, 1239, 1257, 1278, 1321, 1346, 1392, 1495, 1567, 1704, 1826, 1874, 2039, 2663, 2686, 3389, 3431, 3460, 3504, 3552, 3601, 3651, 3783, 3816, 3904, 3998, 4026, 4307], '(892)': [548], 'Google': [549, 568, 585, 602, 695, 718, 743, 804, 827, 852, 891, 914, 965, 1010, 1056, 1145, 1173, 1208, 1241, 1259, 1280, 1323, 1348, 1394, 1497, 1569, 1706, 1828, 1876, 2041, 2665, 2688, 3391, 3433, 3462, 3506, 3554, 3603, 3653, 3785, 3818, 3906, 4000, 4028, 4309], 'Scholar,': [550, 569, 586, 696, 719, 805, 828, 853, 892, 1146, 1174, 1209, 1242, 1260, 1324, 2666, 4001], '2Peterson': [551], 'C.L.': [552], 'Laniel': [553], 'M.-A.': [554], 'Curr.': [555], '2004;': [557, 1388, 1822, 3456, 3495, 3994], '14:': [558], 'R546-R551Abstract': [559], 'Full': [560, 562, 883, 885, 906, 908, 1167, 1253, 1561, 1563, 1698, 1700, 1868, 1870, 2033, 2035, 2657, 2659, 3383, 3385, 3498, 3500, 3898, 3900, 4301, 4303], 'Text': [561, 563, 884, 886, 907, 909, 1168, 1254, 1562, 1564, 1699, 1701, 1869, 1871, 2034, 2036, 2658, 2660, 3384, 3386, 3499, 3501, 3899, 3901, 4302, 4304], 'PDF': [564, 887, 910, 1169, 1255, 1565, 1702, 1872, 2037, 2661, 3387, 3502, 3902, 4305], '(978)': [567], '3Roth': [570], 'S.Y.': [571], 'Denu': [572], 'J.M.': [573], 'Allis': [574, 2673, 4014], 'C.D.': [575, 2674, 3420, 3805, 4015], '2001;': [579, 689, 737, 798, 846, 1342, 3779], '70:': [580], '81-120Crossref': [581], '(1610)': [584], '4Martin': [587], 'C.C.': [588], 'Zhang': [589], 'Y.': [590, 1148, 1184, 1221, 1372, 1376, 1384, 4003], 'Nat.': [591, 1385, 4018], 'Mol.': [593, 878, 901, 1488, 3453, 3493, 3545, 3594, 3991, 4020], 'Cell': [594, 1675], '2005;': [596, 1050, 1558, 1865, 2030, 2654, 3380, 3895, 4298], '6:': [597, 1389], '838-849Crossref': [598], '(1603)': [601], 'Scholar).': [603, 744, 915, 966, 1011, 1057, 1395, 1570, 1829, 1877, 2042, 2689, 3604, 3654, 3786], 'large': [605], 'number': [606, 1912, 2587, 3111, 3118, 3123, 4185, 4189, 4193, 4198], 'methyltransferases': [609, 931, 973, 1079], 'contain': [610, 927], 'domains': [612, 3708], 'catalyze': [614], 'addition': [616], 'methyl': [618], 'groups': [619], 'lysine': [621], 'residues.': [622], 'Prominent': [623], 'sites': [624, 766], 'methylation': [628, 638], 'include': [629], 'H3-Lys4,': [631], 'euchromatin,': [636], 'H3-Lys9,': [641], 'heterochromatin.': [646], 'The': [647, 967, 1531, 1571, 1599, 1640, 1922, 1941, 1953, 2096, 2159, 2201, 2210, 2288, 2622, 3152, 3828, 4047, 4313], 'sole': [653, 3396], 'multimeric': [662], 'COMPASS': [665, 1529, 1539], '(5Miller': [666, 775], 'T.': [667, 776, 1036, 1150, 1186, 1213, 1217], 'Krogan': [668, 777], 'N.J.': [669, 778, 855], 'Dover': [670, 779, 856], 'Erdjument-Bromage': [672, 781], 'H.': [673, 782, 1152, 1178], 'Tempst': [674, 783], 'P.': [675, 784, 1326], 'Johnston': [676, 785, 872], 'M.': [677, 730, 786, 839, 873, 1374, 1380, 3444, 3492, 3772, 3982], 'Greenblatt': [678, 787, 874], 'J.F.': [679, 788, 875], 'Shilatifard': [680, 789, 876], 'Proc.': [682, 705, 791, 814, 1043, 1132, 1195, 1228, 1267, 2675], 'Natl.': [683, 706, 792, 815, 1044, 1133, 1196, 1229, 1268, 2676], 'Acad.': [684, 707, 793, 816, 1045, 1134, 1197, 1230, 1269, 2677], 'Sci.': [685, 708, 794, 817, 1046, 1135, 1198, 1231, 1270, 2678], 'U.': [686, 709, 795, 818, 1047, 1136, 1199, 1232, 1271, 2679], 'S.': [687, 710, 796, 819, 937, 941, 982, 986, 1048, 1137, 1200, 1233, 1246, 1272, 1295, 1299, 2680, 3625, 3629, 4009], '98:': [690, 799], '12902-12907Crossref': [691, 800], '(456)': [694, 803], '6Nagy': [697, 806], 'P.L.': [698, 807], 'Griesenbeck': [699, 808], 'Kornberg': [701, 810], 'R.D.': [702, 811], 'Cleary': [703, 812, 1247, 3451, 3989], 'M.L.': [704, 813, 1248, 3452, 3990], '2002;': [712, 821, 1695], '99:': [713, 822], '90-94Crossref': [714, 823], '(265)': [717, 826], '7Roguev': [720, 829], 'Schaft': [722, 831, 938, 983, 1296, 3626, 3764], 'Shevchenko': [724, 833, 3766], 'Pim': [726, 835, 3768], 'Pijnappel': [727, 836, 3769], 'W.': [728, 837, 3424, 3450, 3770, 3809, 3988], 'Wilm': [729, 838, 3771], 'Aasland': [731, 840, 950, 995, 1308, 3638, 3773], 'R.': [732, 841, 951, 996, 1154, 1211, 1219, 1309, 1338, 1370, 1382, 2670, 3639, 3774], 'Stewart': [733, 842, 956, 1001, 1314, 3644, 3775], 'A.F.': [734, 843, 957, 1002, 1315, 3645, 3776], 'EMBO': [735, 844, 3777], '20:': [738, 847, 1492, 3780], '7137-7148Crossref': [739, 848, 3781], '(458)': [742, 851, 3784], 'recruited': [747], 'by': [748, 1358, 1950, 2140, 2150, 2207, 2337, 2582, 2620, 2630, 2722, 2725, 2745, 2859, 2873, 2909, 3053, 3149, 3308, 3934, 4096, 4129, 4169, 4229, 4240], 'RNA': [750, 1361, 2757, 2798, 3057, 3755], 'polymerase': [751, 2854], 'II': [752], 'machinery': [753], 'actively': [755, 1026], 'expressed': [756, 1027, 2372, 4061], 'genes,': [757], 'subsequent': [759], 'trimethylation': [760], 'these': [765, 1077, 1419, 1636, 1665], 'provides': [767], 'localized': [769, 1021], 'mark': [770], 'recent': [772], 'transcriptional': [773], 'activity': [774, 1579], '8Krogan': [854], 'Wood': [858], 'Schneider': [860], 'Heidt': [862], 'Boateng': [864], 'M.A.': [865], 'Dean': [866], 'K.': [867, 900, 943, 953, 988, 998, 1301, 1311, 3631, 3641], 'Ryan': [868], 'O.W.': [869], 'Golshani': [870], 'Cell.': [879, 902, 1163, 1249, 1386, 1489, 3454, 3494, 3546, 3595, 3992], '2003;': [880, 903, 3427, 3548, 3597, 3812], '11:': [881, 904], '721-729Abstract': [882], '(568)': [890], '9Ng': [893], 'H.-H.': [894], 'Robert': [895], 'F.': [896, 947, 992, 1305, 3635], 'Young': [897, 1041, 1335], 'R.A.': [898, 1042], 'Struhl': [899], '709-719Abstract': [905], '(855)': [913], 'Although': [916, 1073], 'express': [918], 'single': [921, 1087], 'methyltransferase,': [924, 1619], 'cells': [926, 1679, 1710, 1777, 1807, 2003, 2785, 3183, 3879, 4070, 4154, 4214, 4252], 'approximately': [928], '12': [929], 'exhibit': [933, 1669, 3405, 3683], 'this': [934, 1610, 3823], 'specificity': [935], '(10Glaser': [936, 981, 1294, 3624], 'Lubitz': [940, 985, 1298, 3628], 'Vintersten': [942, 987, 1300, 3630], 'van': [944, 989, 1302, 3632], 'der': [945, 990, 1303, 3633], 'Hoeven': [946, 991, 1304, 3634], 'Tufteland': [948, 993, 1306, 3636], 'K.R.': [949, 994, 1307, 3637], 'Anastassiadis': [952, 997, 1310, 3640], 'Ang': [954, 999, 1312, 3642], 'S.-L.': [955, 1000, 1313, 3643], 'Development.': [958, 1003, 1316, 3646], '133:': [960, 1005, 1318, 3648], '1423-1432Crossref': [961, 1006, 1319, 3649], '(228)': [964, 1009, 1144, 1322, 3652], 'Set1-like': [968, 1638], 'family': [969, 1091], 'includes': [974, 3753], 'Set1A,': [975, 1542, 1835], 'MLL,': [976], 'MLL2,': [977], 'MLL3,': [978], 'MLL4': [980, 3557], 'Similar': [1012, 4260, 4341], 'MLL': [1019, 1107, 1286, 3436, 3960], '5′-end': [1024], '(11Guenther': [1029], 'M.G.': [1030], 'Jenner': [1031], 'R.G.': [1032, 2672, 3530, 3579, 4017], 'Chevalier': [1033], 'B.': [1034, 1336, 1717, 1740], 'Nakamura': [1035, 1149, 1185, 1216, 1383], 'Croce': [1037, 1159, 1189, 1224], 'C.M.': [1038, 1160, 1190, 1225, 3466], 'Canaani': [1039, 1155, 1161, 1187, 1226], 'E.': [1040, 1162, 1188, 1227, 2709, 3522, 3571], '102:': [1051], '8603-8608Crossref': [1052], '(278)': [1055], 'major': [1059], 'unanswered': [1060], 'question': [1061], 'concerns': [1062], 'significance': [1064], 'complexity': [1067], 'methyltransferases.': [1072], 'generally': [1074], 'expressed,': [1076], 'provide': [1080], 'functions,': [1082], 'as': [1083, 1685, 1812, 1855, 2021, 2339, 2644, 3001, 3012, 3067, 3126, 3661, 3844], 'loss': [1084], 'member': [1088], 'can': [1092], 'lead': [1093], 'disease': [1095], 'death.': [1097], 'For': [1098], 'example,': [1099], 'chromosomal': [1100], 'translocations': [1101], 'involving': [1102], 'encoding': [1105, 1924], 'frequently': [1112], 'found': [1113], 'leukemia': [1115, 2775, 2807], '(12Domer': [1116], 'P.H.': [1117], 'Fakharzadeh': [1118], 'S.S.': [1119, 3474], 'Chen': [1120], 'C.S.': [1121], 'Jockel': [1122], 'Johansen': [1124], 'L.': [1125], 'Silverman': [1126], 'G.A.': [1127], 'Kersey': [1128], 'J.H.': [1129], 'Korsmeyer': [1130], 'S.J.': [1131], '1993;': [1139, 1202], '90:': [1140, 1203], '7884-7888Crossref': [1141], '13Gu': [1147], 'Alder': [1151, 1177], 'Prasad': [1153], 'O.': [1156, 3468], 'Cimino': [1157], '1992;': [1164, 1250], '71:': [1165, 1251], '701-708Abstract': [1166], '(794)': [1172], '14Ma': [1175], 'Q.': [1176], 'Nelson': [1179], 'K.K.': [1180], 'Chatterjee': [1181], 'Gu': [1183, 1220], 'Siracusa': [1191], 'L.D.': [1192], 'Buchberg': [1193], 'A.M.': [1194, 1264], '6350-6354Crossref': [1204], '(129)': [1207], '15Prasad': [1210], 'Yano': [1212], 'Sorio': [1214], 'C.': [1215], 'Rallapalli': [1218], 'Leshkowitz': [1222], '1995;': [1235], '92:': [1236], '12160-12164Crossref': [1237], '(119)': [1240], '16Tkachuk': [1243], 'D.C.': [1244], 'Kohler': [1245], '691-700Abstract': [1252], '(862)': [1258], '17Zeleznik-Le': [1261], 'N.': [1262], 'Harden': [1263], 'Rowley': [1265], 'J.D.': [1266], '1994;': [1274], '91:': [1275], '10610-10614Crossref': [1276], '(212)': [1279], 'Scholar);': [1281, 1349], 'genetic': [1282], 'disruption': [1283], 'MLL2': [1288, 3464], 'leads': [1290, 1363], 'embryonic': [1292, 1457, 1464, 1677, 1804], 'lethality': [1293], '18Ayton': [1325], 'Sneddon': [1327], 'S.F.': [1328], 'Palmer': [1329], 'D.B.': [1330], 'Rosewell': [1331], 'I.R.': [1332], 'Owen': [1333], 'M.J.': [1334], 'Presley': [1337], 'Subramanian': [1339], 'V.': [1340], 'Genesis.': [1341, 1821], '30:': [1343], '201-212Crossref': [1344], '(64)': [1347], 'depletion': [1351], 'SMYD3': [1354], 'small': [1359], 'interfering': [1360], 'treatment': [1362], 'suppression': [1365], 'cell': [1367, 1721, 1744, 1773, 1976, 2006, 2488, 2574], 'growth': [1368], '(19Hamamoto': [1369], 'Furukawa': [1371], 'Morita': [1373], 'Iimura': [1375], 'Silva': [1377], 'F.P.': [1378], 'Li': [1379], 'Yagyu': [1381], '731-740Crossref': [1390], '(628)': [1393], 'It': [1396], 'likely': [1398], 'function': [1401], 'result': [1409], 'distinct': [1411], 'specificity,': [1414, 2734], 'nature': [1417], 'targets': [1421], 'mechanisms': [1424], 'utilized': [1425], 'achieve': [1427], 'subnuclear': [1429], 'targeting': [1430], 'unknown.': [1436], 'cloned': [1439], 'CXXC': [1440, 1450], 'finger': [1441, 1451], '1': [1443, 1987, 2068, 2083, 2849, 2880, 2885, 2890, 3225, 3287], '(CFP1)': [1444], '3The': [1445], 'abbreviations': [1446], 'used': [1447, 2017, 2714, 3000, 3138, 3157], 'are:': [1448], 'CFP,': [1449], 'protein;': [1452], 'aa,': [1453], 'amino': [1454, 1925, 4335], 'acid;': [1455], 'ES,': [1456], 'stem;': [1458], 'GAPDH,': [1459], 'glyceraldehyde-3-phosphate': [1460, 3025], 'dehydrogenase;': [1461], 'HEK,': [1462], 'kidney;': [1465], 'PBS,': [1466], 'phosphate-buffered': [1467, 2510], 'saline;': [1468], 'RT,': [1469], 'reverse': [1470, 2802, 2809], 'transcriptase;': [1471], 'GST,': [1472], 'glutathione': [1473], 'S-transferase;': [1474], 'PIPES,': [1475, 2056], '1,4-piperazinediethanesulfonic': [1476], 'acid.': [1477], '(20Voo': [1478], 'K.S.': [1479, 3480], 'Carlone': [1480], 'D.L.': [1481], 'Jacobsen': [1482], 'B.M.': [1483], 'Flodin': [1484], 'Skalnik': [1486, 1553, 1690, 1819, 1860, 2025, 2649, 3375, 3890, 4293], 'D.G.': [1487, 1554, 1691, 1820, 1861, 2026, 2650, 3376, 3891, 4294], '2000;': [1491], '2108-2121Crossref': [1493], '(153)': [1496], 'Scholar),': [1498, 1707, 3392, 3434, 3463, 3507, 3555, 3819, 3907, 4029, 4310], 'homologue': [1501], 'Spp1,': [1504], 'component': [1506, 3883], 'Biochemical': [1514], 'purification': [1515], 'CFP1': [1519, 1532, 4183], 'revealed': [1521], 'it': [1522, 1621, 3870], 'be': [1524, 4176], 'homologues': [1536], 'Wdr82': [1547, 1841, 4317, 4331], '(previously': [1548], 'hSwd2)': [1550], '(21Lee': [1551, 1858, 2023, 2647, 3373, 3888, 4291], 'J.-H.': [1552, 1689, 1816, 1859, 2024, 2648, 3374, 3889, 4292], '280:': [1559, 1866, 2031, 2655, 3381, 3896, 4299], '41725-41731Abstract': [1560, 1867, 2032, 2656, 3382, 3897, 4300], '(247)': [1568, 1875, 2040, 2664, 3390, 3905, 4308], 'Set1A-CFP1': [1573, 3969], 'exhibits': [1575, 1591], 'vitro.': [1581], 'predicted': [1587], 'high': [1592], 'homology': [1593, 3830], 'protein.': [1598, 4340], 'purpose': [1600], 'studies': [1603, 4320], 'reported': [1604, 3360], 'here': [1605], 'was': [1606, 1753, 1914, 1930, 1948, 1984, 2138, 2162, 2191, 2203, 2212, 2290, 2371, 2383, 2428, 2449, 2624, 2628, 2758, 2801, 2826, 2901, 3051, 3058, 3065, 3137, 3156, 3172, 3250, 3337, 3856, 4059, 4262], 'examine': [1608], 'whether': [1609, 1620], 'novel': [1611], 'Set1B,': [1614, 3834], 'functional': [1617, 1633], 'similar': [1626, 3701, 3716, 3734, 3747], 'COMPASS,': [1628], 'assess': [1631, 2732], 'possible': [1632], 'interactions': [1634], 'between': [1635, 3831], 'enzymes.': [1639], 'presented': [1642], 'demonstrates': [1643], 'indistinguishable': [1650], 'from': [1651, 1916, 2002, 2430, 2442, 2451, 2465, 2480, 2708, 2760, 2985, 3060, 3086, 3878, 4151, 4213, 4251], '(except': [1655], 'methyltransferase),': [1662], 'overlapping': [1671], 'properties.': [1674], 'Lines—Human': [1676], 'kidney': [1678], '(HEK293)': [1680], 'were': [1681, 1711, 1723, 1778, 1808, 1843, 1884, 2000, 2045, 2098, 2124, 2129, 2148, 2155, 2174, 2225, 2237, 2264, 2302, 2310, 2331, 2402, 2417, 2440, 2463, 2478, 2498, 2506, 2521, 2533, 2556, 2576, 2616, 2642, 2713, 2720, 2737, 2863, 2921, 2933, 2963, 2999, 3011, 3084, 3092, 3184, 3203, 3221, 3258, 3282, 3290, 3296, 3313, 3908, 3917, 3932, 3941, 4071, 4081, 4087, 4094, 4101, 4115, 4134, 4143, 4149, 4165, 4173, 4223, 4238, 4244], 'cultured': [1682, 1809, 3198], 'transfected': [1684, 1709, 1720, 4155], 'described': [1687, 1814, 1857, 2022, 2645, 3068, 4288], '(22Lee': [1688], '277:': [1696], '42259-42267Abstract': [1697], '(42)': [1705], 'selected': [1712, 1780, 2922], '200': [1714, 1782], 'μg/ml': [1715, 1738, 1768, 1783, 1788, 1796, 1801, 1988, 2080, 2093, 2185, 3278, 3300], 'hygromycin': [1716, 1739, 1784, 1797], 'Established': [1718], 'stably': [1719], 'lines': [1722, 2489], 'maintained': [1724, 1754, 1791], "Dulbecco's": [1726, 1756], 'modified': [1727, 1757], "Eagle's": [1728, 1758], 'medium': [1729, 1759, 2515, 2524, 2541, 2561], 'supplemented': [1730, 1760, 2071], '10%': [1732, 1762], 'bovine': [1733, 1763, 3235, 3273], 'calf': [1734, 1764], 'serum': [1735, 1765, 3236], '50': [1737, 1795, 2841], 'T-REx': [1742, 1775, 1974, 2514, 4063, 4152], 'HEK293': [1743, 1776, 1975, 2487, 4064, 4153], 'line': [1745, 1977], '(Invitrogen)': [1746, 2811], 'constitutively': [1748], 'expresses': [1749, 1980], 'tetracycline': [1751], 'repressor': [1752], '5': [1767, 1787, 1800, 3305], 'blasticidin.': [1769, 1802], 'To': [1770, 2731, 4066, 4200], 'establish': [1771], 'inducible': [1772], 'lines,': [1774], 'transfected,': [1779], 'B': [1785, 1798], 'blasticidin,': [1789], 'media': [1793], 'containing': [1794, 2091, 2183, 2542, 2562, 2991, 3074, 3232, 3264, 4054], 'Mouse': [1803, 3120], 'stem': [1805], '(ES)': [1806], 'differentiated': [1811, 2764], '(23Lee': [1815], 'Hart': [1817], 'S.R.L.': [1818], '38:': [1823], '32-38Crossref': [1824], '(230)': [1827], 'Plasmid': [1830], 'Construction—Expression': [1831], 'vectors': [1832], 'carrying': [1833, 2009, 2490, 4253], 'cDNAs': [1842], 'prepared': [1844, 2001, 2577, 3066, 3909, 4082, 4250], 'using': [1845, 1886, 2117, 2193, 2233, 2282, 2319, 2338, 2592, 2748, 2786, 2804, 4321], 'pcDNA3.1/Hygro': [1847], 'vector': [1848, 1896, 2015, 2492, 4159, 4257], 'carries': [1850], 'amino-terminal': [1852, 1901, 1938, 4056], 'FLAG': [1853, 1902, 1939, 2019, 2094, 2170, 2186, 3913, 3920, 4057, 4090, 4097, 4124, 4226, 4248], 'epitope,': [1854, 4058], 'Various': [1878], 'deletion': [1879], 'constructs': [1880, 1947], 'subcloned': [1885, 1931], 'PCR': [1888, 1958, 2919, 2931, 2947, 2958, 2961, 2977, 2988, 3135, 3141], 'restriction': [1890, 2904, 2936, 2966, 3006], 'enzyme': [1891, 2905, 2937, 2967, 3007], 'digestions': [1892], 'into': [1893, 1932], 'pcDNA5/TO': [1895, 1933], '(Invitrogen),': [1897], 'encodes': [1899, 1936], 'epitope.': [1903, 1940], 'partial': [1905], 'cDNA': [1906, 1923, 2823, 2998, 3064], '(KIAA1076,': [1910], 'accession': [1911], 'AB028999)': [1913], 'obtained': [1915, 2429, 2441, 2450, 2464, 2479], 'Kazusa': [1918], 'DNA': [1919, 1951, 2853, 2900, 3105], 'Research': [1920, 2790], 'Institute.': [1921], '(aa)': [1927], 'residues': [1928, 3710, 3728, 3740, 3760], '1120–1923': [1929], 'vector,': [1934], 'nucleotide': [1942, 1954], 'sequence': [1943], 'plasmid': [1946], 'confirmed': [1949], 'sequencing.': [1952], 'sequences': [1955], 'oligonucleotide': [1957], 'primers': [1959, 2920], 'available': [1961], 'upon': [1962], 'request.': [1963], 'Purification': [1964], 'Complex': [1968], 'Identification': [1970, 3848], 'Its': [1972], 'Components—A': [1973], 'inducibly': [1979], 'FLAG-Set1B': [1981, 2011, 4112, 4220], '(aa': [1982, 2345, 2350, 2355, 2360, 2366, 2392, 2496, 2613, 4052, 4221], '1120–1923)': [1983, 4222], 'treated': [1985, 2499], 'doxycycline': [1990, 2501, 4074], '4': [1992, 2503, 4076], 'days': [1993, 2770, 4077], 'induce': [1995], 'Nuclear': [1998, 3875, 4085], 'extracts': [1999, 2401, 2575, 3876, 4080, 4086, 4211], '(5': [2004, 2767, 2799], 'ml': [2005, 2050, 2179], 'pellet': [2007], 'volume)': [2008], 'parental': [2013], 'immunoprecipitation': [2020, 2581, 4125, 4227, 4265], 'Bound': [2043, 2172, 2415, 3915], 'proteins': [2044, 2173, 2416, 3404, 3667, 3682, 3695, 3916, 3940, 4093, 4271], 'eluted': [2046, 2175, 2265, 2418, 3918, 4095], 'twice': [2047, 2176, 2508], '0.5': [2049], 'binding': [2052, 2181, 3792, 3825], 'buffer': [2053, 2182, 2857], '(10': [2054], 'mm': [2055, 2060, 2063, 2066, 2069, 2084, 2836], 'pH': [2057], '7.0,': [2058], '300': [2059, 2062], 'NaCl,': [2061], 'sucrose,': [2064], '3': [2065, 2410], 'MgCl2,': [2067], 'EGTA,': [2070], 'protease': [2074], 'inhibitors': [2075], 'leupeptin,': [2076], 'aprotinin,': [2077], 'pepstatin': [2078], '(1': [2079], 'each),': [2081], 'phenylmethylsulfonyl': [2085], 'fluoride,': [2086], '0.5%': [2088], 'Triton': [2089, 3216], 'X-100)': [2090], '250': [2092, 2184, 2280], 'peptide.': [2095], 'eluants': [2097, 4100], 'combined': [2099], 'loaded': [2101], 'onto': [2102, 2251, 3186], '10–50%': [2103, 3926, 4104], 'sucrose': [2104, 3927, 4105], 'gradients': [2105], 'subjected': [2107, 2164, 2219, 2579, 2902, 2934, 2964, 3911, 4088, 4118, 4224], 'centrifugation': [2109, 3855], '38,000': [2111], '×': [2112, 2255, 3190], 'g': [2113], '18': [2115], 'h': [2116, 2411, 3226], 'SW41': [2119], 'rotor': [2120], '(Beckman).': [2121], 'Five-hundred-milliliter': [2122], 'fractions': [2123, 3931, 4108], 'collected.': [2125], 'Molecular': [2126], 'weight': [2127], 'markers': [2128], 'applied': [2130], 'parallel': [2133], 'gradient,': [2134, 3928], 'their': [2136], 'migration': [2137], 'analyzed': [2139, 2619, 2721, 2744, 2908, 3933, 4168], 'Coomassie': [2141, 2215, 2726], 'Blue': [2142, 2217, 2727], 'staining.': [2143, 2222], 'Fractions': [2144], 'enriched': [2145, 4109], 'Western': [2151, 2398, 2746, 3935, 4230, 4274], 'blotting': [2152, 2747], 'pooled': [2156, 2160, 4116], '(fractions': [2157], '11–14).': [2158], 'sample': [2161, 2202, 2421], 'then': [2163, 2534, 3173, 3212, 3222, 4127], 'second': [2167, 4121], 'round': [2168, 4122], 'immunoprecipitation.': [2171, 3914], '0.25': [2178], 'peptide,': [2187, 4098], 'eluant': [2190], 'concentrated': [2192], 'Amicon': [2195], 'Ultra-4': [2196], 'concentrator': [2197], '(100': [2198], 'cutoff).': [2200], 'denatured': [2204, 2617, 2865], 'separated': [2206, 3923, 4102], '4–12%': [2208], 'SDS-PAGE.': [2209, 2621, 4130], 'gel': [2211, 2623, 2911], 'stained': [2213], 'Brilliant': [2216], 'silver': [2221], 'Protein': [2223, 2485], 'bands': [2224, 4133, 4164], 'excised': [2226, 4166], 'processed': [2228], 'in-gel': [2230], 'trypsin': [2231], 'digestion': [2232, 2906, 2938, 2968], 'standard': [2234, 3145], 'protocols.': [2235], 'Peptides': [2236], 'extracted': [2238], '0.1%': [2240], 'trifluoroacetic': [2241], '30': [2244, 2273, 2874], 'min': [2245, 2274, 2539, 2895, 3306], '37': [2247], '°C': [2248, 2818, 2868, 2878, 2883, 2888], 'injected': [2250], '75': [2253], 'μm': [2254], '5-cm': [2256], 'C-18': [2257], 'reverse-phase': [2258], 'column': [2259, 2289], '(Waters,': [2260], 'Picofrit': [2261], 'column),': [2262], '5–45%': [2268], 'acetonitrile': [2269], 'gradient': [2270, 3853, 3930], 'developed': [2271], 'over': [2272, 3175], 'flow': [2277], 'rate': [2278], 'nl/min': [2281], 'Agilent': [2284], '1100': [2285], 'series': [2286], 'nanopump.': [2287], 'interfaced': [2291], 'LTQ': [2294], 'ion': [2295], 'trap': [2296], 'spectrometer': [2298], '(Thermo),': [2299], 'collected': [2303], 'triple-play': [2306], 'mode.': [2307], 'MS/MS': [2308], 'spectra': [2309], 'searched': [2311], 'against': [2312, 2387], 'IPI': [2314], 'SEQUEST.': [2320], 'Generation': [2321], 'Polyclonal': [2323], 'Antisera—Anti-Set1A,': [2324], 'anti-Set1B,': [2325], 'anti-CFP1,': [2326], 'anti-Wdr5,': [2327], 'anti-Wdr82': [2329], 'antisera': [2330, 2380, 2439, 2462, 2477], 'generated': [2332, 2386], 'rabbits': [2334], '(Proteintech': [2335, 2394], 'Group)': [2336], 'antigens': [2340], 'recombinant': [2342, 2347, 2352, 2357, 2363, 2389, 2703], 'GST-Set1A': [2343, 2390], '258–458),': [2346], 'GST-Set1B': [2348], '1444–1596),': [2351], 'GST-CFP1': [2353], '213–367),': [2356], 'GST-Wdr5': [2358], '1–334),': [2361], 'GST-Wdr82': [2364], '1–173).': [2367], 'Each': [2368], 'antigen': [2370], 'Escherichia': [2374], 'coli': [2375, 2710], 'affinity': [2377], 'purified.': [2378], 'Goat': [2379], 'recognizing': [2381], 'similarly': [2385], '795–993)': [2393], 'Group).': [2395], 'Blotting': [2399], 'Analysis—Nuclear': [2400], 'incubated': [2403, 2522, 2559, 3223, 3253, 3285], 'anti-FLAG': [2405], 'M2-agarose': [2406], 'beads': [2407], '(Sigma)': [2408], 'extensively': [2413], 'washed.': [2414], 'SDS': [2420], 'buffer.': [2422], 'Anti-FLAG': [2423], '(mouse': [2424], 'monoclonal': [2425], 'M2)': [2426], 'antibody': [2427, 2605], 'Sigma,': [2431], 'anti-Ash2': [2432], '(rabbit': [2433, 2437, 2446, 2456, 2460, 2470, 2475], 'polyclonal)': [2434, 2438, 2447, 2457, 2461, 2471, 2476], 'anti-Rbbp5': [2436], 'Bethyl': [2443], 'Laboratories,': [2444, 2585], 'anti-Brg1': [2445], 'antiserum': [2448], 'Santa': [2452], 'Cruz': [2453], 'Biotechnology,': [2454, 2467], 'anti-H3K4me2': [2455], 'anti-H3K9me2': [2459], 'Upstate': [2466], 'anti-H3K4me3': [2469], 'anti-histone': [2473], 'Abcam.': [2481], 'Pulse-Chase': [2482], 'Analysis': [2483, 2751], 'Stability—T-REx': [2486], 'empty': [2491, 4157, 4255], 'FLAG-Set1A': [2494, 2611], '1082–1707)': [2497], 'days.': [2504], 'Cells': [2505, 2532, 2555, 3202, 3220, 3257, 3289, 3312], 'rinsed': [2507, 2557], 'saline': [2511], '(PBS)': [2512], 'lacking': [2516, 2525], 'methionine': [2517, 2526, 2565], 'cysteine,': [2519], 'cysteine': [2528, 2567], '15': [2530], 'min.': [2531, 2821], 'metabolically': [2535], 'labeled': [2536], '45': [2538], '0.1': [2543, 3299], 'mCi/ml': [2544], '[35S]Met/Cys': [2545], 'mixture': [2546, 2832], '(EasyTag': [2547], 'Expres35S': [2548], 'labeling': [2550], 'mix,': [2551], 'PerkinElmer': [2552], 'Life': [2553], 'Sciences).': [2554], 'excess': [2563], 'cold': [2564], 'indicated': [2570], 'time': [2571], 'points.': [2572], 'Whole': [2573], 'anti-Set1A': [2583, 2604], '(Bethyl': [2584], 'catalog': [2586, 3110, 3117], 'BL1193)': [2588], 'anti-Set1B': [2590, 3246], 'antibodies': [2591], 'rabbit': [2594, 3247], 'IgG': [2595, 3243, 3248], 'TrueBlot': [2596], 'kit': [2597], '(eBioscience).': [2598], 'As': [2599], 'demonstrated': [2600], 'Fig.': [2602], '6C,': [2603], 'recognizes': [2606], '1082–1707).': [2614], 'Immunoprecipitates': [2615], 'dried': [2625], 'radioactivity': [2627], 'quantitated': [2629], 'phosphorimager': [2631], '(Bio-Rad': [2633], 'Personal': [2634], 'FX': [2635], 'System).': [2636], 'Histone': [2637], 'Methyltransferase': [2638], 'Assay—Histone': [2639], 'performed': [2643, 3338, 3857, 4263], '24Strahl': [2667], 'B.D.': [2668], 'Ohba': [2669], 'Cook': [2671], '1999;': [2682], '96:': [2683], '14967-14972Crossref': [2684], '(413)': [2687], 'Either': [2690], '10': [2691, 2769, 2894, 3316], 'μg': [2692, 2701], 'purified': [2694, 2707], 'core': [2695], 'histones': [2696], '(Upstate': [2697, 2711], 'Biotechnology)': [2698, 2712], '2': [2700, 2870, 3255], 'reactions.': [2717], 'Reaction': [2718], 'products': [2719, 2736, 2932, 2962, 3142], 'SDS-PAGE': [2723], 'followed': [2724, 2872, 3307, 4228], 'staining': [2728], 'fluorography.': [2730], 'reaction': [2735, 2831], 'transferred': [2738], 'polyvinylidene': [2740], 'difluoride': [2741], 'membrane': [2742], 'modification-specific': [2749], 'antisera.': [2750], 'Expression—Total': [2756], 'isolated': [2759, 3059, 3877, 4150, 4212], 'undifferentiated': [2761], 'ES': [2762], 'cells,': [2763], 'embryoid': [2765], 'bodies': [2766], 'following': [2771, 3143, 4264], 'removal': [2773], 'inhibitory': [2776], 'factor),': [2777], 'HEK293,': [2779], 'HEL,': [2780], 'K562,': [2781], 'Jurkat,': [2782], 'HeLa': [2784], 'TriReagent': [2787], 'solution': [2788, 3230], '(Molecular': [2789], 'Center)': [2791], 'per': [2792], "manufacturer's": [2794], 'recommended': [2795, 3148], 'protocol.': [2796], 'Total': [2797, 3056], 'μg)': [2800, 2825], 'transcribed': [2803], 'Moloney': [2805], 'murine': [2806, 2994, 3014, 3031, 3037, 3049], 'virus': [2808], 'transcriptase': [2810], 'random': [2813], 'hexamers': [2814], '(Roche)': [2815, 2855], '42': [2817], '60': [2820], 'Single-stranded': [2822], '(0.1': [2824], 'amplified': [2827, 2917], '50-μl': [2830], 'included': [2834], '0.2': [2835], 'deoxynucleoside': [2839], 'triphosphate,': [2840], 'pmol': [2842], 'sense': [2844], 'antisense': [2846], 'primers,': [2847], 'unit': [2850], 'Taq': [2852], 'supplied': [2858], 'manufacturer.': [2861, 3151], 'Samples': [2862], 'heat': [2864], '94': [2867, 2877], 'min,': [2871, 2881, 2886, 2891], 'cycles': [2875], '55': [2882], '72': [2887, 2897], 'finally': [2893], '°C.': [2898], 'Amplified': [2899], 'agarose': [2910], 'electrophoresis': [2912], 'along': [2913], 'undigested': [2916], 'DNA.': [2918], 'amplify': [2924], 'cDNA.': [2929], 'Human': [2930, 3663, 3691], 'PmlI,': [2940], 'cleave': [2944, 2974], 'product': [2948, 2978, 2984], 'generates': [2950], '189-': [2951], '261-bp': [2953], 'fragments': [2954], 'product.': [2959, 2989], 'Murine': [2960], 'AflIII,': [2970], '190-bp': [2982], 'doublet': [2983], 'Plasmids': [2990], 'amplification': [3004, 3100, 3146], 'digestion.': [3008], 'Primer': [3009, 3090], 'pairs': [3010, 3091], 'follows:': [3013], 'Set1,': [3015, 3020, 3675], '5′-AACCAGCTCAAGTTTCG-3′': [3016], '5′-GGGAACTTGTAGTCGTA-3;': [3018], '5′-AGATGACCATCCTGTATGACA-3′': [3021], '5′-TCCGGAACTTGAGCTGGTTGA-3′;': [3023], 'dehydrogenase': [3026], '(GAPDH),': [3027], '5′-ACAGTCCATGCCATCACTGCCACTC-3′': [3028], '5′-CCAGCCCCAGCATCAAAGGTGG-3′;': [3030], 'Oct4,': [3032], '5′-GGCGTTCTCTTTGGAAAGGTGTTC-3′': [3033], '5′-CTCGAACCACATCCTTCTCT-3′;': [3035], 'HPRT,': [3038], '5′-CACAGGACTAGAACACCTGC-3′': [3039], '5′-GCTGGTGAAAAGGACCTCT-3′.': [3041], 'Relative': [3042], 'tissues': [3050, 3062], 'determined': [3052, 4174], 'quantitative': [3054], 'RT-PCR.': [3055], 'mouse': [3061], 'above.': [3069], 'TaqMan': [3070], 'primer': [3076], 'probe': [3079], '(FAM': [3080], 'fluorescent': [3081], 'reporter': [3082], 'dye)': [3083], 'purchased': [3085], 'PE': [3087], 'Applied': [3088, 3131], 'Biosystems.': [3089], 'located': [3093], 'different': [3096], 'exons': [3097], 'avoid': [3099], 'any': [3102], 'contaminating': [3103], 'genomic': [3104], '(Exon': [3108, 3115], '6–7,': [3109], 'Mm00626143_m1)': [3112], '5–6,': [3116], 'Mm00616971_m1).': [3119], 'GAPDH': [3121, 3169], '(catalog': [3122], '4352932E)': [3124], 'served': [3125], 'control.': [3129], 'An': [3130], 'Biosystems': [3132], '7500': [3133], 'Real-Time': [3134], 'System': [3136], 'detect': [3140, 4316], 'protocol': [3147], 'comparative': [3153], 'CT': [3154], 'method': [3155], 'determine': [3159], 'relative': [3160], 'compared': [3166], 'control,': [3170], 'averaged': [3174], 'three': [3176, 3260, 3292, 3964], 'independent': [3177], 'experiments.': [3178], 'Immunofluorescence': [3179], 'Microscopy—HEK293': [3182], 'seeded': [3185], 'coverglass': [3187], '2–5': [3189], '104': [3191], 'cells/well': [3192], '24-well': [3195], 'dish': [3196], '24': [3200], 'h.': [3201, 3256, 3288], 'fixed': [3204], '4%': [3206], '(v/v)': [3207], 'paraformaldehyde': [3208], 'PBS': [3210, 3263, 3303], 'permeabilized': [3213], '0.2%': [3215, 3238, 3265], 'X-100': [3217], 'PBS.': [3219, 3311], 'blocking': [3229, 3280], '(PBS': [3231], '2.5%': [3233], 'normal': [3234], 'Tween': [3239, 3266], '20).': [3240], 'Anti-Set1A': [3241], 'goat': [3242], '(1:250)': [3244, 3249], 'added': [3251, 3283], 'washed': [3259, 3291], 'times': [3261, 3293], '20.': [3267], 'Bovine': [3268], 'anti-goat': [3269], 'IgG-Texas': [3270], 'Red': [3271], 'anti-rabbit': [3274], 'IgG-fluorescein': [3275], 'isothiocyanate': [3276], '(2': [3277], 'solution)': [3281], 'nuclei': [3295], 'counterstained': [3297], '4,6-diamidino-2-phenylindole': [3301], 'washing': [3309], 'mounted': [3314], 'μl': [3317], 'Fluoromount': [3319], 'G': [3320], '(Southern': [3321], 'Biotechnology': [3322], 'Associates)': [3323], 'scanned': [3325], 'Zeiss': [3328], 'LSM': [3329], '510': [3330], 'laser': [3331], 'scanning': [3332], 'confocal': [3333], 'microscope.': [3334], 'Indiana': [3341, 3348], 'Center': [3342], 'Biological': [3344], 'Microscopy': [3345], 'University': [3349], 'School': [3350], 'Medicine.': [3352], 'KIAA1076': [3353, 3622, 3660], 'Is': [3354], 'Highly': [3355], 'Homologous': [3356], 'Set1A—We': [3358], 'Set1-COMPASS': [3371], 'yeast.': [3401], 'Several': [3402, 4131], 'significant': [3406], 'similarity': [3407, 3688], '(25Wysocka': [3415, 3800], 'Myers': [3417, 3802], 'M.P.': [3418, 3803], 'Laherty': [3419, 3804], 'Eisenmann': [3421, 3806], 'R.N.': [3422, 3807], 'Herr': [3423, 3449, 3808, 3987], 'Genes': [3425, 3810], 'Dev.': [3426, 3811], '17:': [3428, 3813], '896-911Crossref': [3429, 3814], '(320)': [3432, 3817], '(26Yokoyama': [3437, 3975], 'Wang': [3439, 3977], 'Z.': [3440, 3978], 'Wysocka': [3441, 3979], 'Sanyal': [3443, 3981], 'Aufiero': [3445, 3983], 'D.J.': [3446, 3984], 'Kitabayashi': [3447, 3985], 'I.': [3448, 3986], '24:': [3457, 3995], '5639-5649Crossref': [3458, 3996], '(531)': [3461, 3999], '(27Hughes': [3465], 'Rozenblatt-Rosen': [3467], 'Milne': [3469, 4004], 'T.A.': [3470, 4005], 'Copeland': [3471], 'T.D.': [3472], 'Levine': [3473], 'Lee': [3475, 3539, 3541, 3543, 3588, 3590, 3592, 4008, 4010], 'J.C.': [3476], 'Hayes': [3477], 'D.N.': [3478], 'Shanmugam': [3479], 'Bhattacharjee': [3481], 'Biondi': [3483], 'C.A.': [3484], 'Kay': [3485], 'G.F.': [3486], 'Hayward': [3487], 'N.K.': [3488], 'Hess': [3489], 'J.L.': [3490], 'Meyerson': [3491], '13:': [3496, 4023], '587-597Abstract': [3497], '(505)': [3505], 'MLL3': [3508], '(28Goo': [3509, 3558], 'Y.-H.': [3510, 3559], 'Sohn': [3511, 3560], 'Y.C.': [3512, 3542, 3561, 3591], 'Kim': [3513, 3515, 3562, 3564], 'D.-H.': [3514, 3563], 'S.-W.': [3516, 3565], 'Kang': [3517, 3566], 'M.-J.': [3518, 3567], 'Jung': [3519, 3568], 'D.-J.': [3520, 3569], 'Kwak': [3521, 3570], 'Barlev': [3523, 3572], 'N.A.': [3524, 3573], 'Berger': [3525, 3574], 'S.L.': [3526, 3575], 'Chow': [3527, 3576], 'V.T.': [3528, 3577], 'Roeder': [3529, 3578, 4016], 'Azorsa': [3531, 3580], 'D.O.': [3532, 3581], 'Meltzer': [3533, 3582], 'P.S.': [3534, 3583], 'Suh': [3535, 3584], 'P.-G.': [3536, 3585], 'Song': [3537, 3586], 'E.J.': [3538, 3587], 'K.-J.': [3540, 3589], 'J.W.': [3544, 3593, 4011], '23:': [3549, 3598], '140-149Crossref': [3550, 3599], '(186)': [3553, 3602], 'most': [3613], 'closely': [3614], 'related': [3615], 'Hereafter,': [3655], 'we': [3656, 4030], 'will': [3657], 'refer': [3658], 'share': [3668], '35': [3669], '37%': [3671], 'respectively,': [3676], '56%': [3687], '(Fig.': [3689, 3951, 4083, 4160, 4258, 4272, 4327, 4352], '1).': [3690], '85%': [3697], 'identical': [3698, 3713, 3731, 3744], '97%': [3700], 'throughout': [3702, 3717, 3748, 3836], 'post-SET': [3707], '(Set1A': [3709, 3739, 3759], '1563–1707),': [3711], '60%': [3712], '78%': [3715], 'region': [3719, 3738, 3751, 4049], '(N-SET': [3725], 'domain,': [3726, 3839], '1414–1562),': [3729], '46%': [3730], '66%': [3733], 'central': [3737], '786–916),': [3741], '61%': [3743], '83%': [3746], 'NH2-terminal': [3750], 'recognition': [3756], 'motif': [3757, 3793, 3826], '85–173)': [3761], '(7Roguev': [3762], 'additionally': [3788], 'HCF-1': [3791, 3797, 3824], 'interacts': [3795, 3962, 4040, 4332], 'vivo': [3799], 'lacks': [3822], 'domain.': [3827], 'extensive': [3829], 'particularly': [3835], 'suggests': [3840], 'functions': [3843], 'Complex—Sucrose': [3852], 'equilibrium': [3854], 'analyze': [3859], 'size': [3861], 'native': [3864], 'compare': [3869], 'expressing': [3880, 4215], 'FLAG-CFP1,': [3881], 'peptide': [3921], 'on': [3924, 4103], 'blotting.': [3936], 'co-immunoprecipitated': [3943], 'FLAG-CFP1': [3945], 'co-migrate': [3947], '2A).': [3952], 'Because': [3953], 'carboxyl-terminal': [3955, 4048, 4113], '(Ash2,': [3971], 'Wdr5)': [3974], '29Dou': [4002], 'Ruthenburg': [4006], 'A.J.': [4007], 'Verdine': [4012], 'G.L.': [4013], 'Struct.': [4019], '713-719Crossref': [4024], '(569)': [4027], 'reasoned': [4031], 'highly': [4034], 'conserved': [4035], 'its': [4044], 'cognate': [4045], '1120–1923),': [4053], 'conditionally': [4060], 'cells.': [4065], 'purify': [4067], 'Set1B-associated': [4068], 'induced': [4072], '2B).': [4084], 'immunoprecipitation,': [4091], 'bound': [4092], 'gradients.': [4106], 'Gradient': [4107], 'visualized': [4128], 'specifically': [4135], 'FLAG-tagged': [4139, 4346], 'fragment,': [4141], 'apparent': [4145], 'samples': [4147], '2C).': [4161], 'Set1B-interacting': [4162], 'spectrometry.': [4171], '(accession': [4184, 4188, 4192, 4197], 'NP_055408),': [4186], 'Ash2': [4187], 'NP_004665.1),': [4190], 'Rbbp5': [4191], 'NP_005048.1),': [4194], 'Wdr5': [4196, 4237], 'NP_060058.1).': [4199], 'further': [4201], 'evaluate': [4202], 'authenticity': [4204], 'putative': [4207], 'blot': [4231], 'analysis.': [4232], 'detected': [4239, 4246], 'specific': [4241], 'antisera,': [4242], 'immunoprecipitates': [4249], '3A).': [4259], '3B).': [4273], 'immunoprecipitated': [4277], 'material': [4278], 'presence': [4281], 'members': [4284], 'failure': [4314], 'co-immunoprecipitation': [4319], 'half': [4324, 4336], '2C)': [4328], 'inability': [4344], 'immunoprecipitate': [4350], '3A),': [4353], 'immunopr': [4354]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2054205113', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 12}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 17}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 16}, {'year': 2012, 'cited_by_count': 18}], 'updated_date': '2025-01-06T13:15:25.378972', 'created_date': '2016-06-24'}