Title: Synthesis and Biological Validation of Novel Synthetic Histone/Protein Methyltransferase Inhibitors
Abstract: Coding control: Protein arginine methyltransferases (PRMTs) and histone lysine methyltransferases (HKMTs) are epigenetic enzymes involved in regulation of gene expression and cellular processes. A new series of histone/protein methyltransferase inhibitors based on the 1,5-diphenyl-1,4-pentadien-3-one scaffold is reported. The described compounds showed various degrees of selectivity against the tested PRMTs (PRMT1 and CARM1) and HKMT (SET7).
Publication Year: 2007
Publication Date: 2007-06-27
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 55
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