Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2053815283', 'doi': 'https://doi.org/10.1021/bi700650k', 'title': 'Recognition of the Inner Lipoyl-Bearing Domain of Dihydrolipoyl Transacetylase and of the Blood Glucose-Lowering Compound AZD7545 by Pyruvate Dehydrogenase Kinase 2', 'display_name': 'Recognition of the Inner Lipoyl-Bearing Domain of Dihydrolipoyl Transacetylase and of the Blood Glucose-Lowering Compound AZD7545 by Pyruvate Dehydrogenase Kinase 2', 'publication_year': 2007, 'publication_date': '2007-06-30', 'ids': {'openalex': 'https://openalex.org/W2053815283', 'doi': 'https://doi.org/10.1021/bi700650k', 'mag': '2053815283', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17602666', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2136408'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi700650k', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2136408?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5049786612', 'display_name': 'Alina Tuganova', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32389192', 'display_name': 'University of Alabama at Birmingham', 'ror': 'https://ror.org/008s83205', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32389192']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alina Tuganova', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama, Birmingham, Alabama 35294'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama, Birmingham, Alabama 35294', 'institution_ids': ['https://openalex.org/I32389192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002232743', 'display_name': 'Alla Klyuyeva', 'orcid': 'https://orcid.org/0009-0009-8380-3434'}, 'institutions': [{'id': 'https://openalex.org/I32389192', 'display_name': 'University of Alabama at Birmingham', 'ror': 'https://ror.org/008s83205', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32389192']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alla Klyuyeva', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama, Birmingham, Alabama 35294'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama, Birmingham, Alabama 35294', 'institution_ids': ['https://openalex.org/I32389192']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5057486236', 'display_name': 'Kirill M. Popov', 'orcid': 'https://orcid.org/0000-0002-8033-2552'}, 'institutions': [{'id': 'https://openalex.org/I32389192', 'display_name': 'University of Alabama at Birmingham', 'ror': 'https://ror.org/008s83205', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32389192']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kirill M. Popov', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama, Birmingham, Alabama 35294'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Genetics, Schools of Medicine and Dentistry, University of Alabama, Birmingham, Alabama 35294', 'institution_ids': ['https://openalex.org/I32389192']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.036, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 14, 'citation_normalized_percentile': {'value': 0.722734, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 85, 'max': 86}, 'biblio': {'volume': '46', 'issue': '29', 'first_page': '8592', 'last_page': '8602'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12915', 'display_name': 'Biochemical Acid Research Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12915', 'display_name': 'Biochemical Acid Research Studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1303', 'display_name': 'Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13012', 'display_name': 'Coenzyme Q10 studies and effects', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12763', 'display_name': 'ATP Synthase and ATPases Research', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dihydrolipoyl-transacetylase', 'display_name': 'Dihydrolipoyl transacetylase', 'score': 0.8602117}, {'id': 'https://openalex.org/keywords/dihydrolipoamide-dehydrogenase', 'display_name': 'Dihydrolipoamide dehydrogenase', 'score': 0.47497934}], 'concepts': [{'id': 'https://openalex.org/C80097345', 'wikidata': 'https://www.wikidata.org/wiki/Q419036', 'display_name': 'Dihydrolipoyl transacetylase', 'level': 5, 'score': 0.8602117}, {'id': 'https://openalex.org/C88099638', 'wikidata': 'https://www.wikidata.org/wiki/Q412856', 'display_name': 'Pyruvate dehydrogenase complex', 'level': 3, 'score': 0.84524643}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.61946744}, {'id': 'https://openalex.org/C2780854706', 'wikidata': 'https://www.wikidata.org/wiki/Q900970', 'display_name': 'Pyruvate kinase', 'level': 4, 'score': 0.57160544}, {'id': 'https://openalex.org/C9506865', 'wikidata': 'https://www.wikidata.org/wiki/Q6321025', 'display_name': 'Pyruvate dehydrogenase kinase', 'level': 4, 'score': 0.5230735}, {'id': 'https://openalex.org/C101972281', 'wikidata': 'https://www.wikidata.org/wiki/Q899965', 'display_name': 'Pyruvate decarboxylation', 'level': 4, 'score': 0.4920625}, {'id': 'https://openalex.org/C179402230', 'wikidata': 'https://www.wikidata.org/wiki/Q14865383', 'display_name': 'Pyruvate dehydrogenase lipoamide kinase isozyme 1', 'level': 5, 'score': 0.47925162}, {'id': 'https://openalex.org/C120763696', 'wikidata': 'https://www.wikidata.org/wiki/Q419337', 'display_name': 'Dihydrolipoamide dehydrogenase', 'level': 4, 'score': 0.47497934}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.46600753}, {'id': 'https://openalex.org/C36503486', 'wikidata': 'https://www.wikidata.org/wiki/Q11235244', 'display_name': 'Domain (mathematical analysis)', 'level': 2, 'score': 0.42115375}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.25828123}, {'id': 'https://openalex.org/C20251656', 'wikidata': 'https://www.wikidata.org/wiki/Q162643', 'display_name': 'Glycolysis', 'level': 3, 'score': 0.21697518}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.10283896}, {'id': 'https://openalex.org/C134306372', 'wikidata': 'https://www.wikidata.org/wiki/Q7754', 'display_name': 'Mathematical analysis', 'level': 1, 'score': 0.058204114}], 'mesh': [{'descriptor_ui': 'D000813', 'descriptor_name': 'Anilides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D051047', 'descriptor_name': 'Dihydrolipoyllysine-Residue Acetyltransferase', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D008063', 'descriptor_name': 'Thioctic Acid', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000813', 'descriptor_name': 'Anilides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002942', 'descriptor_name': 'Circular Dichroism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051047', 'descriptor_name': 'Dihydrolipoyllysine-Residue Acetyltransferase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051047', 'descriptor_name': 'Dihydrolipoyllysine-Residue Acetyltransferase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017354', 'descriptor_name': 'Point Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011487', 'descriptor_name': 'Protein Conformation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000081382', 'descriptor_name': 'Pyruvate Dehydrogenase Acetyl-Transferring Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008063', 'descriptor_name': 'Thioctic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008063', 'descriptor_name': 'Thioctic Acid', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D008063', 'descriptor_name': 'Thioctic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/bi700650k', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S104038378', 'display_name': 'Biochemistry', 'issn_l': '0006-2960', 'issn': ['0006-2960', '1520-4995', '1943-295X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2136408', 'pdf_url': 'https://europepmc.org/articles/pmc2136408?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2136408', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17602666', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2136408', 'pdf_url': 'https://europepmc.org/articles/pmc2136408?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1517812011', 'https://openalex.org/W1593825810', 'https://openalex.org/W1775749144', 'https://openalex.org/W1832257936', 'https://openalex.org/W1885970184', 'https://openalex.org/W1910275359', 'https://openalex.org/W1966723933', 'https://openalex.org/W1970100772', 'https://openalex.org/W1975171610', 'https://openalex.org/W1975333713', 'https://openalex.org/W1975757233', 'https://openalex.org/W1977466946', 'https://openalex.org/W1980438140', 'https://openalex.org/W1988827801', 'https://openalex.org/W2003621319', 'https://openalex.org/W2009526294', 'https://openalex.org/W2011646732', 'https://openalex.org/W2014791035', 'https://openalex.org/W2018289835', 'https://openalex.org/W2041096022', 'https://openalex.org/W2045371106', 'https://openalex.org/W2048127465', 'https://openalex.org/W2053291546', 'https://openalex.org/W2055341741', 'https://openalex.org/W2056282717', 'https://openalex.org/W2056816046', 'https://openalex.org/W2060809301', 'https://openalex.org/W2061266943', 'https://openalex.org/W2076812146', 'https://openalex.org/W2099421147', 'https://openalex.org/W2100837269', 'https://openalex.org/W2106970085', 'https://openalex.org/W2108326741', 'https://openalex.org/W2130452502', 'https://openalex.org/W2136611430', 'https://openalex.org/W2138270253', 'https://openalex.org/W2138710796', 'https://openalex.org/W2144285975', 'https://openalex.org/W2153938802', 'https://openalex.org/W2156946803', 'https://openalex.org/W2166679041', 'https://openalex.org/W2167123876', 'https://openalex.org/W2334261900', 'https://openalex.org/W2342610199', 'https://openalex.org/W2402223713', 'https://openalex.org/W4233270123'], 'related_works': ['https://openalex.org/W992578657', 'https://openalex.org/W74304500', 'https://openalex.org/W2369281961', 'https://openalex.org/W2184209744', 'https://openalex.org/W204747089', 'https://openalex.org/W2015269539', 'https://openalex.org/W2000725524', 'https://openalex.org/W1998850551', 'https://openalex.org/W1975622822', 'https://openalex.org/W1490403537'], 'abstract_inverted_index': {'Pyruvate': [0], 'dehydrogenase': [1, 18], 'kinase': [2, 10, 59], '2': [3], '(PDHK2)': [4], 'is': [5, 23, 260], 'a': [6, 103, 145, 203], 'unique': [7], 'mitochondrial': [8], 'protein': [9], 'that': [11, 144, 242], 'regulates': [12], 'the': [13, 16, 32, 38, 62, 69, 75, 78, 83, 91, 113, 119, 127, 134, 137, 165, 178, 181, 230, 237, 243, 249], 'activity': [14, 235, 259], 'of': [15, 27, 37, 43, 71, 85, 105, 129, 136, 139, 147, 180, 189, 232], 'pyruvate': [17], 'multienzyme': [19], 'complex': [20], '(PDC).': [21], 'PDHK2': [22, 72, 88, 93, 122, 130, 148, 184, 195, 212, 234, 252, 258], 'an': [24, 53], 'integral': [25], 'component': [26, 41], 'PDC': [28], 'tightly': [29], 'bound': [30], 'to': [31, 50, 55, 111, 202], 'inner': [33], 'lipoyl-bearing': [34], 'domains': [35], '(L2)': [36], 'dihydrolipoyl': [39], 'transacetylase': [40], '(E2)': [42], 'PDC.': [44], 'This': [45], 'association': [46], 'has': [47], 'been': [48], 'reported': [49], 'bring': [51], 'about': [52], 'up': [54], '10-fold': [56], 'increase': [57], 'in': [58, 68, 74, 151, 164, 176, 236], 'activity.': [60], 'Despite': [61], 'central': [63], 'role': [64], 'played': [65], 'by': [66, 87, 131, 194], 'E2': [67], 'maintenance': [70, 231], 'functionality': [73], 'PDC-bound': [76], 'state,': [77], 'molecular': [79, 106], 'mechanisms': [80], 'responsible': [81], 'for': [82, 90, 118, 126, 192, 229], 'recognition': [84, 193], 'L2': [86, 124, 190, 254], 'and': [89, 108, 123, 125, 161, 163, 172, 185, 201, 208, 224, 253, 255], 'E2-dependent': [92], 'activation': [94, 128], 'are': [95, 174, 226], 'largely': [96], 'unknown.': [97], 'In': [98], 'this': [99], 'study,': [100], 'we': [101], 'used': [102], 'combination': [104], 'modeling': [107], 'site-directed': [109, 140], 'mutagenesis': [110], 'identify': [112], 'amino': [114], 'acid': [115], 'residues': [116, 149, 188, 213], 'essential': [117, 191], 'interaction': [120, 182], 'between': [121, 183, 251], 'E2.': [132], 'On': [133], 'basis': [135], 'results': [138], 'mutagenesis,': [141], 'it': [142], 'appears': [143], 'number': [146], 'located': [150], 'its': [152], 'R': [153], 'domain': [154], '(P22,': [155], 'L23,': [156], 'F28,': [157], 'F31,': [158, 221], 'F44,': [159, 222], 'L45,': [160], 'L160)': [162], 'so-called': [166], '"cross': [167], 'arm"': [168], 'structure': [169], '(K368,': [170], 'R372,': [171, 223], 'K391)': [173], 'critical': [175, 228], 'determining': [177], 'strength': [179], 'L2.': [186], 'The': [187], 'include': [196], 'L140,': [197], 'K173,': [198], 'I176,': [199], 'E179,': [200], 'lesser': [204], 'extent': [205], 'D164,': [206], 'D172,': [207], 'A174.': [209], 'Importantly,': [210], 'certain': [211], 'forming': [214], 'interfaces': [215], 'with': [216], 'L2,': [217], 'i.e.,': [218], 'K17,': [219], 'P22,': [220], 'K391,': [225], 'also': [227], 'enhanced': [233], 'E2-bound': [238], 'state.': [239], 'Finally,': [240], 'evidence': [241], 'blood': [244], 'glucose-lowering': [245], 'compound': [246], 'AZD7545': [247], 'disrupts': [248], 'interactions': [250], 'thereby': [256], 'inhibits': [257], 'presented.': [261]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2053815283', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-17T07:06:35.085764', 'created_date': '2016-06-24'}