Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2053516651', 'doi': 'https://doi.org/10.1001/jama.1995.03520480053039', 'title': 'T-Helper 1-Type Immunity to Trophoblast in Women With Recurrent Spontaneous Abortion', 'display_name': 'T-Helper 1-Type Immunity to Trophoblast in Women With Recurrent Spontaneous Abortion', 'publication_year': 1995, 'publication_date': '1995-06-28', 'ids': {'openalex': 'https://openalex.org/W2053516651', 'doi': 'https://doi.org/10.1001/jama.1995.03520480053039', 'mag': '2053516651', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/7783303'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1001/jama.1995.03520480053039', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S172573765', 'display_name': 'JAMA', 'issn_l': '0098-7484', 'issn': ['0098-7484', '1538-3598'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320259', 'host_organization_name': 'American Medical Association', 'host_organization_lineage': ['https://openalex.org/P4310320259'], 'host_organization_lineage_names': ['American Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5107929520', 'display_name': 'Joseph A. Hill', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Joseph A. Hill', 'raw_affiliation_strings': ["Fearing Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA."], 'affiliations': [{'raw_affiliation_string': "Fearing Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA.", 'institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5107929520'], 'corresponding_institution_ids': ['https://openalex.org/I1283280774', 'https://openalex.org/I136199984'], 'apc_list': None, 'apc_paid': None, 'fwci': 6.461, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 495, 'citation_normalized_percentile': {'value': 0.999844, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '273', 'issue': '24', 'first_page': '1933', 'last_page': '1933'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11510', 'display_name': 'Reproductive System and Pregnancy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11510', 'display_name': 'Reproductive System and Pregnancy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12096', 'display_name': 'Ectopic Pregnancy Diagnosis and Management', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10584', 'display_name': 'Reproductive Physiology in Livestock', 'score': 0.9913, 'subfield': {'id': 'https://openalex.org/subfields/1102', 'display_name': 'Agronomy and Crop Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/trophoblast', 'display_name': 'Trophoblast', 'score': 0.79141504}], 'concepts': [{'id': 'https://openalex.org/C2777495146', 'wikidata': 'https://www.wikidata.org/wiki/Q1889778', 'display_name': 'Trophoblast', 'level': 5, 'score': 0.79141504}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.68547034}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.60330045}, {'id': 'https://openalex.org/C137061746', 'wikidata': 'https://www.wikidata.org/wiki/Q736033', 'display_name': 'Peripheral blood mononuclear cell', 'level': 3, 'score': 0.59297806}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.5683765}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.5109052}, {'id': 'https://openalex.org/C16685009', 'wikidata': 'https://www.wikidata.org/wiki/Q335057', 'display_name': 'Andrology', 'level': 1, 'score': 0.45384568}, {'id': 'https://openalex.org/C2780841837', 'wikidata': 'https://www.wikidata.org/wiki/Q24741149', 'display_name': 'Interferon gamma', 'level': 3, 'score': 0.44725165}, {'id': 'https://openalex.org/C74172505', 'wikidata': 'https://www.wikidata.org/wiki/Q194908', 'display_name': 'Interleukin', 'level': 3, 'score': 0.43360716}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.36037472}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.34071118}, {'id': 'https://openalex.org/C2779234561', 'wikidata': 'https://www.wikidata.org/wiki/Q11995', 'display_name': 'Pregnancy', 'level': 2, 'score': 0.3076281}, {'id': 'https://openalex.org/C172680121', 'wikidata': 'https://www.wikidata.org/wiki/Q26513', 'display_name': 'Fetus', 'level': 3, 'score': 0.24601042}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19436231}, {'id': 'https://openalex.org/C2776953305', 'wikidata': 'https://www.wikidata.org/wiki/Q1212935', 'display_name': 'Placenta', 'level': 4, 'score': 0.13749525}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.092693776}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000026', 'descriptor_name': 'Abortion, Habitual', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011247', 'descriptor_name': 'Pregnancy', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D018417', 'descriptor_name': 'Th1 Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D014327', 'descriptor_name': 'Trophoblasts', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000026', 'descriptor_name': 'Abortion, Habitual', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015331', 'descriptor_name': 'Cohort Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004622', 'descriptor_name': 'Embryo, Mammalian', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011247', 'descriptor_name': 'Pregnancy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018417', 'descriptor_name': 'Th1 Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018417', 'descriptor_name': 'Th1 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014327', 'descriptor_name': 'Trophoblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014327', 'descriptor_name': 'Trophoblasts', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1001/jama.1995.03520480053039', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S172573765', 'display_name': 'JAMA', 'issn_l': '0098-7484', 'issn': ['0098-7484', '1538-3598'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320259', 'host_organization_name': 'American Medical Association', 'host_organization_lineage': ['https://openalex.org/P4310320259'], 'host_organization_lineage_names': ['American Medical Association'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/7783303', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.81, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W1495896580', 'https://openalex.org/W1510730676', 'https://openalex.org/W151088397', 'https://openalex.org/W1514549604', 'https://openalex.org/W1532278869', 'https://openalex.org/W1546288178', 'https://openalex.org/W1578766902', 'https://openalex.org/W181323389', 'https://openalex.org/W1853022482', 'https://openalex.org/W1882195644', 'https://openalex.org/W1897632974', 'https://openalex.org/W1941412517', 'https://openalex.org/W1942668068', 'https://openalex.org/W1973750057', 'https://openalex.org/W1979105454', 'https://openalex.org/W1979661906', 'https://openalex.org/W1986672594', 'https://openalex.org/W1990197546', 'https://openalex.org/W2005246059', 'https://openalex.org/W2009248667', 'https://openalex.org/W2020191064', 'https://openalex.org/W2034249407', 'https://openalex.org/W2041034005', 'https://openalex.org/W2073056113', 'https://openalex.org/W2075942059', 'https://openalex.org/W2078735513', 'https://openalex.org/W2083185383', 'https://openalex.org/W2084990572', 'https://openalex.org/W2098430467', 'https://openalex.org/W2104538381', 'https://openalex.org/W2127977816', 'https://openalex.org/W2128707261', 'https://openalex.org/W2133602875', 'https://openalex.org/W2153639301', 'https://openalex.org/W2172466148', 'https://openalex.org/W2258124562', 'https://openalex.org/W2316637423', 'https://openalex.org/W270965262'], 'related_works': ['https://openalex.org/W2425854203', 'https://openalex.org/W2394478663', 'https://openalex.org/W2365828934', 'https://openalex.org/W2183091990', 'https://openalex.org/W2171087992', 'https://openalex.org/W2081482521', 'https://openalex.org/W2061584516', 'https://openalex.org/W2042331917', 'https://openalex.org/W1998018864', 'https://openalex.org/W1600496839'], 'abstract_inverted_index': {'To': [0], 'test': [1], 'the': [2, 124, 223], 'hypothesis': [3], 'that': [4], 'peripheral': [5, 45], 'blood': [6, 46, 194], 'mononuclear': [7, 47], 'cells': [8, 48, 197], 'in': [9, 21, 112, 121, 130, 188, 249], 'women': [10, 31, 199, 210, 232], 'with': [11, 32, 75, 142, 148, 200, 242], 'unexplained': [12], 'recurrent': [13], 'abortion': [14], '(URA)': [15], 'produce': [16], 'T-helper': [17], '1': [18], '(TH1)-type': [19], 'cytokines': [20, 96, 104, 185], 'response': [22, 258], 'to': [23, 238, 259, 262], 'trophoblast': [24, 239, 260], 'antigens.Cohort': [25], 'study.Medical': [26], 'center.A': [27], 'total': [28], 'of': [29, 116, 123, 134, 145, 152, 198], '244': [30, 117, 135], 'URA,': [33], '13': [34, 80], 'reproductively': [35, 81, 208, 230], 'normal': [36, 82, 209, 231], 'parous': [37, 83], 'control': [38], 'women,': [39, 84], 'and': [40, 60, 78, 85, 107, 120, 138, 180, 211, 244], '10': [41, 86], 'men.Supernatants': [42], 'from': [43, 49, 71, 114, 132, 163, 190, 207, 229], 'trophoblast-activated': [44, 204], 'all': [50, 169], 'participants': [51], 'were': [52, 88, 170, 186, 214], 'tested': [53, 90], 'for': [54, 66, 93, 166, 172, 175, 178, 182], 'toxic': [55], 'effects': [56], 'on': [57], 'mouse': [58], 'embryos': [59], 'by': [61, 91], 'enzyme-linked': [62], 'immunosorbent': [63], 'assay': [64], '(ELISA)': [65], 'interferon': [67], 'gamma': [68, 127], '(IFN-gamma).': [69], 'Supernatants': [70], '20': [72, 161], 'URA': [73, 118, 136, 243], 'patients': [74, 119, 137, 164], 'embryotoxic': [76, 215], 'activity': [77, 109], 'IFN-gamma,': [79], 'men': [87, 212], 'further': [89, 167], 'ELISA': [92], 'other': [94], 'TH1-type': [95, 218, 236], '(interleukin-2': [97], '[IL-2],': [98], 'tumor': [99], 'necrosis': [100], 'factor-beta': [101], '[TNF-beta]),': [102], 'TH2-type': [103, 224, 252], '(IL-4,': [105], 'IL-10),': [106], 'TNF-alpha.Embryotoxic': [108], 'was': [110, 128, 139], 'detected': [111, 129, 187], 'supernatants': [113, 131, 147, 154, 162, 189, 206, 228], '160': [115, 146], 'none': [122], 'controls.': [125], 'Interferon': [126], '125': [133], 'significantly': [140], 'associated': [141, 241], 'embryotoxicity': [143, 149, 156], '(121': [144], 'vs': [150], 'four': [151], '84': [153], 'without': [155], '[P': [157], '<': [158], '.001]).': [159], 'Of': [160], 'chosen': [165], 'study,': [168], 'positive': [171], 'TNF-alpha,': [173], '17': [174], 'TNF-beta,': [176], 'two': [177], 'IL-10,': [179], 'one': [181], 'IL-4.': [183], 'No': [184], 'unstimulated': [191], 'or': [192], 'red': [193], 'cell': [195], 'membrane-activated': [196], 'URA.': [201], 'In': [202], 'contrast,': [203], 'lymphocyte': [205], 'neither': [213], 'nor': [216], 'contained': [217, 222, 234], 'cytokines,': [219], 'but': [220], 'most': [221], 'cytokine': [225], 'IL-10.': [226], 'Three': [227], 'also': [233], 'IL-4.Whereas': [235], 'immunity': [237, 253], 'is': [240], 'may': [245, 254], 'play': [246], 'a': [247, 256], 'role': [248], 'reproductive': [250], 'failure,': [251], 'be': [255], 'natural': [257], 'contributing': [261], 'successful': [263], 'pregnancy.': [264]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2053516651', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 14}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-12-21T07:32:58.439316', 'created_date': '2016-06-24'}