Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1998018864', 'doi': 'https://doi.org/10.1111/j.1574-695x.2006.00075.x', 'title': 'Periodontopathic bacterial endotoxin-induced tumor necrosis factor α production was inhibited by exercise in mice', 'display_name': 'Periodontopathic bacterial endotoxin-induced tumor necrosis factor α production was inhibited by exercise in mice', 'publication_year': 2006, 'publication_date': '2006-02-24', 'ids': {'openalex': 'https://openalex.org/W1998018864', 'doi': 'https://doi.org/10.1111/j.1574-695x.2006.00075.x', 'mag': '1998018864', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16831213'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1574-695x.2006.00075.x', 'pdf_url': 'https://academic.oup.com/femspd/article-pdf/47/2/262/19169111/47-2-262.pdf', 'source': {'id': 'https://openalex.org/S136462399', 'display_name': 'FEMS Immunology & Medical Microbiology', 'issn_l': '0928-8244', 'issn': ['0928-8244', '1574-695X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/femspd/article-pdf/47/2/262/19169111/47-2-262.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5102291083', 'display_name': 'Tetsuo Kato', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149564915', 'display_name': 'Tokyo Dental College', 'ror': 'https://ror.org/0220f5b41', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I149564915']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tetsuo Kato', 'raw_affiliation_strings': ['Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba, Japan.', 'institution_ids': ['https://openalex.org/I149564915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103628574', 'display_name': 'Sachiko Kaneko', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149564915', 'display_name': 'Tokyo Dental College', 'ror': 'https://ror.org/0220f5b41', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I149564915']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Sachiko Kaneko', 'raw_affiliation_strings': ['Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba, Japan.', 'institution_ids': ['https://openalex.org/I149564915']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084312960', 'display_name': 'Ryuta Kimizuka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149564915', 'display_name': 'Tokyo Dental College', 'ror': 'https://ror.org/0220f5b41', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I149564915']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ryuta Kimizuka', 'raw_affiliation_strings': ['Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba, Japan.', 'institution_ids': ['https://openalex.org/I149564915']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111504212', 'display_name': 'Katsuji Okuda', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I149564915', 'display_name': 'Tokyo Dental College', 'ror': 'https://ror.org/0220f5b41', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I149564915']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Katsuji Okuda', 'raw_affiliation_strings': ['Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, Oral Health Science Center, Tokyo Dental College, Chiba, Japan.', 'institution_ids': ['https://openalex.org/I149564915']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.076, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.726918, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 80, 'max': 81}, 'biblio': {'volume': '47', 'issue': '2', 'first_page': '262', 'last_page': '266'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11585', 'display_name': 'Exercise and Physiological Responses', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2742', 'display_name': 'Rehabilitation'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11585', 'display_name': 'Exercise and Physiological Responses', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2742', 'display_name': 'Rehabilitation'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11968', 'display_name': 'High Altitude and Hypoxia', 'score': 0.9816, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11399', 'display_name': 'Muscle metabolism and nutrition', 'score': 0.9799, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/physical-exercise', 'display_name': 'Physical exercise', 'score': 0.51474667}], 'concepts': [{'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.8766946}, {'id': 'https://openalex.org/C2778754761', 'wikidata': 'https://www.wikidata.org/wiki/Q421804', 'display_name': 'Lipopolysaccharide', 'level': 2, 'score': 0.82268596}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6441995}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.6174876}, {'id': 'https://openalex.org/C74172505', 'wikidata': 'https://www.wikidata.org/wiki/Q194908', 'display_name': 'Interleukin', 'level': 3, 'score': 0.5949696}, {'id': 'https://openalex.org/C503630168', 'wikidata': 'https://www.wikidata.org/wiki/Q178069', 'display_name': 'Necrosis', 'level': 2, 'score': 0.5866891}, {'id': 'https://openalex.org/C3020084786', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor α', 'level': 3, 'score': 0.52642316}, {'id': 'https://openalex.org/C181588539', 'wikidata': 'https://www.wikidata.org/wiki/Q219067', 'display_name': 'Physical exercise', 'level': 2, 'score': 0.51474667}, {'id': 'https://openalex.org/C2781300812', 'wikidata': 'https://www.wikidata.org/wiki/Q178061', 'display_name': 'Shock (circulatory)', 'level': 2, 'score': 0.50923026}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.50112915}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.40026873}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.38843906}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.34766734}], 'mesh': [{'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010805', 'descriptor_name': 'Physical Conditioning, Animal', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016976', 'descriptor_name': 'Aggregatibacter actinomycetemcomitans', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D016976', 'descriptor_name': 'Aggregatibacter actinomycetemcomitans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010805', 'descriptor_name': 'Physical Conditioning, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016966', 'descriptor_name': 'Porphyromonas gingivalis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016966', 'descriptor_name': 'Porphyromonas gingivalis', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018417', 'descriptor_name': 'Th1 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018417', 'descriptor_name': 'Th1 Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1574-695x.2006.00075.x', 'pdf_url': 'https://academic.oup.com/femspd/article-pdf/47/2/262/19169111/47-2-262.pdf', 'source': {'id': 'https://openalex.org/S136462399', 'display_name': 'FEMS Immunology & Medical Microbiology', 'issn_l': '0928-8244', 'issn': ['0928-8244', '1574-695X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16831213', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1574-695x.2006.00075.x', 'pdf_url': 'https://academic.oup.com/femspd/article-pdf/47/2/262/19169111/47-2-262.pdf', 'source': {'id': 'https://openalex.org/S136462399', 'display_name': 'FEMS Immunology & Medical Microbiology', 'issn_l': '0928-8244', 'issn': ['0928-8244', '1574-695X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.67, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1549397047', 'https://openalex.org/W1561143321', 'https://openalex.org/W1567912931', 'https://openalex.org/W1592147317', 'https://openalex.org/W1605898561', 'https://openalex.org/W1777081626', 'https://openalex.org/W1889287864', 'https://openalex.org/W1905898110', 'https://openalex.org/W1916851262', 'https://openalex.org/W1920829566', 'https://openalex.org/W1936301880', 'https://openalex.org/W1963500205', 'https://openalex.org/W1967687886', 'https://openalex.org/W1986848594', 'https://openalex.org/W2001955029', 'https://openalex.org/W2009564860', 'https://openalex.org/W2016960864', 'https://openalex.org/W2033124959', 'https://openalex.org/W2048325240', 'https://openalex.org/W2055090334', 'https://openalex.org/W2061103862', 'https://openalex.org/W2062718181', 'https://openalex.org/W2063366467', 'https://openalex.org/W2093845352', 'https://openalex.org/W2101853656', 'https://openalex.org/W2104934728', 'https://openalex.org/W2117626604', 'https://openalex.org/W2127647469', 'https://openalex.org/W2131520834', 'https://openalex.org/W2146915105', 'https://openalex.org/W2148401329', 'https://openalex.org/W2149631937', 'https://openalex.org/W2152254190', 'https://openalex.org/W2157554312', 'https://openalex.org/W2162965528', 'https://openalex.org/W2166163436', 'https://openalex.org/W2170156191', 'https://openalex.org/W2170451878', 'https://openalex.org/W2214363391', 'https://openalex.org/W2285204915', 'https://openalex.org/W2341046423', 'https://openalex.org/W578905084'], 'related_works': ['https://openalex.org/W2587791650', 'https://openalex.org/W2392741140', 'https://openalex.org/W2385076233', 'https://openalex.org/W2374967587', 'https://openalex.org/W2260954265', 'https://openalex.org/W2164350224', 'https://openalex.org/W2162110762', 'https://openalex.org/W2061953809', 'https://openalex.org/W2045301138', 'https://openalex.org/W2013556833'], 'abstract_inverted_index': {'The': [0, 33, 60, 92], 'effects': [1, 115], 'of': [2, 87, 116], 'exercise': [3, 29, 34, 102, 117], 'on': [4, 118], 'serum': [5, 54, 61, 80, 121], 'interleukin-6': [6, 62, 81, 122], 'and': [7, 22, 30, 52, 63, 90, 113, 123], 'tumor': [8, 64, 93, 124, 134], 'necrosis': [9, 65, 94, 125, 135], 'factor': [10, 66, 95, 126, 136], 'α': [11, 67, 96, 127, 137], 'levels': [12, 68, 128], 'were': [13, 26, 69, 129], 'investigated': [14], 'using': [15, 71], 'mice.': [16], 'Five-week-old': [17], 'female': [18], 'BALB/c': [19], 'mice': [20, 24, 88], '(Th2-biased)': [21], 'C57BL/6': [23], '(Th1-biased)': [25], 'divided': [27], 'into': [28], 'control': [31], 'groups.': [32], 'group': [35], 'was': [36, 50, 55, 98, 109], 'exercised': [37], 'in': [38, 83, 100], 'a': [39, 142], 'rotating': [40], 'basket': [41], 'type': [42], 'treadmill': [43], 'for': [44], '1': [45], 'h': [46], '(5': [47], 'r.p.m.).': [48], 'Blood': [49], 'collected': [51], 'the': [53, 79, 84, 101, 114, 119], 'separated': [56], 'immediately': [57], 'after': [58, 111], 'exercise.': [59], 'measured': [70], 'an': [72], 'Endogen': [73], 'ELISA': [74], 'kit.': [75], 'Exercise': [76, 131], 'significantly': [77], 'increased': [78], 'level': [82, 97], 'two': [85], 'strains': [86], '(P<0.05': [89], 'P<0.01).': [91], 'decreased': [99], 'group.': [103], 'Next,': [104], 'periodontopathic': [105], 'bacterial': [106], 'endotoxin': [107, 146], '(lipopolysaccharide)': [108], 'administered': [110], 'exercise,': [112], 'lipopolysaccharide-induced': [120, 133], 'investigated.': [130], 'inhibited': [132], 'production,': [138], 'suggesting': [139], 'it': [140], 'has': [141], 'defensive': [143], 'action': [144], 'against': [145], 'shock.': [147]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1998018864', 'counts_by_year': [{'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T04:23:43.861329', 'created_date': '2016-06-24'}