Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2053374394', 'doi': 'https://doi.org/10.1126/science.6719109', 'title': 'Replication Timing of Genes and Middle Repetitive Sequences', 'display_name': 'Replication Timing of Genes and Middle Repetitive Sequences', 'publication_year': 1984, 'publication_date': '1984-05-18', 'ids': {'openalex': 'https://openalex.org/W2053374394', 'doi': 'https://doi.org/10.1126/science.6719109', 'mag': '2053374394', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6719109'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.6719109', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5062604834', 'display_name': 'Michael A. Goldman', 'orcid': 'https://orcid.org/0000-0001-7879-4275'}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael A. Goldman', 'raw_affiliation_strings': ['Department of Medicine, Section of Genetics, Baylor College of Medicine'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Section of Genetics, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108567047', 'display_name': 'Gerald P. Holmquist', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gerald P. Holmquist', 'raw_affiliation_strings': ['Department of Medicine, Section of Genetics, Baylor College of Medicine'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Section of Genetics, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091744251', 'display_name': 'Martha C. Gray', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Martha C. Gray', 'raw_affiliation_strings': ['Department of Medicine, Section of Genetics, Baylor College of Medicine'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Section of Genetics, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054092329', 'display_name': 'L. A. Caston', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lucetta A. Caston', 'raw_affiliation_strings': ['Department of Medicine, Section of Genetics, Baylor College of Medicine'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Section of Genetics, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112252382', 'display_name': 'Abhijit Nag', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I181547552', 'display_name': 'Baylor College of Medicine', 'ror': 'https://ror.org/02pttbw34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I181547552', 'https://openalex.org/I2801539370']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Abhijit Nag', 'raw_affiliation_strings': ['Department of Medicine, Section of Genetics, Baylor College of Medicine'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Section of Genetics, Baylor College of Medicine', 'institution_ids': ['https://openalex.org/I181547552']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 15.852, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 561, 'citation_normalized_percentile': {'value': 0.993774, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '224', 'issue': '4650', 'first_page': '686', 'last_page': '692'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/replicate', 'display_name': 'Replicate', 'score': 0.7888794}, {'id': 'https://openalex.org/keywords/housekeeping-gene', 'display_name': 'Housekeeping gene', 'score': 0.69206834}, {'id': 'https://openalex.org/keywords/replication-timing', 'display_name': 'Replication timing', 'score': 0.55029607}, {'id': 'https://openalex.org/keywords/pre-replication-complex', 'display_name': 'Pre-replication complex', 'score': 0.5288312}, {'id': 'https://openalex.org/keywords/licensing-factor', 'display_name': 'Licensing factor', 'score': 0.5099269}, {'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription', 'score': 0.48654857}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8017035}, {'id': 'https://openalex.org/C2781162219', 'wikidata': 'https://www.wikidata.org/wiki/Q26250693', 'display_name': 'Replicate', 'level': 2, 'score': 0.7888794}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.7254055}, {'id': 'https://openalex.org/C33922130', 'wikidata': 'https://www.wikidata.org/wiki/Q419232', 'display_name': 'Housekeeping gene', 'level': 4, 'score': 0.69206834}, {'id': 'https://openalex.org/C73573662', 'wikidata': 'https://www.wikidata.org/wiki/Q130996', 'display_name': 'DNA replication', 'level': 3, 'score': 0.61395377}, {'id': 'https://openalex.org/C2778512757', 'wikidata': 'https://www.wikidata.org/wiki/Q7314076', 'display_name': 'Replication timing', 'level': 4, 'score': 0.55029607}, {'id': 'https://openalex.org/C41141232', 'wikidata': 'https://www.wikidata.org/wiki/Q3685229', 'display_name': 'Pre-replication complex', 'level': 5, 'score': 0.5288312}, {'id': 'https://openalex.org/C54266558', 'wikidata': 'https://www.wikidata.org/wiki/Q6543075', 'display_name': 'Licensing factor', 'level': 5, 'score': 0.5099269}, {'id': 'https://openalex.org/C141231307', 'wikidata': 'https://www.wikidata.org/wiki/Q7020', 'display_name': 'Genome', 'level': 3, 'score': 0.5062}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.4915267}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.48654857}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.35601035}, {'id': 'https://openalex.org/C58337764', 'wikidata': 'https://www.wikidata.org/wiki/Q976651', 'display_name': 'Origin of replication', 'level': 4, 'score': 0.35518628}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C105795698', 'wikidata': 'https://www.wikidata.org/wiki/Q12483', 'display_name': 'Statistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C33923547', 'wikidata': 'https://www.wikidata.org/wiki/Q395', 'display_name': 'Mathematics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005796', 'descriptor_name': 'Genes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012091', 'descriptor_name': 'Repetitive Sequences, Nucleic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001001', 'descriptor_name': 'Anura', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002843', 'descriptor_name': 'Chromatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002843', 'descriptor_name': 'Chromatin', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006367', 'descriptor_name': 'HeLa Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009693', 'descriptor_name': 'Nucleic Acid Hybridization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012093', 'descriptor_name': 'Replicon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1126/science.6719109', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S3880285', 'display_name': 'Science', 'issn_l': '0036-8075', 'issn': ['0036-8075', '1095-9203'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315823', 'host_organization_name': 'American Association for the Advancement of Science', 'host_organization_lineage': ['https://openalex.org/P4310315823'], 'host_organization_lineage_names': ['American Association for the Advancement of Science'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6719109', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 78, 'referenced_works': ['https://openalex.org/W1230038830', 'https://openalex.org/W141292933', 'https://openalex.org/W1426271323', 'https://openalex.org/W1487534034', 'https://openalex.org/W1510293025', 'https://openalex.org/W1513454033', 'https://openalex.org/W1520592610', 'https://openalex.org/W1541534570', 'https://openalex.org/W1570782502', 'https://openalex.org/W1574410335', 'https://openalex.org/W1966583531', 'https://openalex.org/W1968095512', 'https://openalex.org/W1969842104', 'https://openalex.org/W1973503553', 'https://openalex.org/W1975018414', 'https://openalex.org/W1975460184', 'https://openalex.org/W1978659501', 'https://openalex.org/W1981210273', 'https://openalex.org/W1982303333', 'https://openalex.org/W1983923110', 'https://openalex.org/W1984101604', 'https://openalex.org/W1986834928', 'https://openalex.org/W1992066230', 'https://openalex.org/W1992751725', 'https://openalex.org/W1997606084', 'https://openalex.org/W1997652060', 'https://openalex.org/W1997681444', 'https://openalex.org/W2004776010', 'https://openalex.org/W2007627498', 'https://openalex.org/W2008189553', 'https://openalex.org/W2010916267', 'https://openalex.org/W2012880496', 'https://openalex.org/W2017216895', 'https://openalex.org/W2017255140', 'https://openalex.org/W2017916255', 'https://openalex.org/W2019340297', 'https://openalex.org/W2020089973', 'https://openalex.org/W2024878014', 'https://openalex.org/W2027862346', 'https://openalex.org/W2029282244', 'https://openalex.org/W2030166063', 'https://openalex.org/W2031687390', 'https://openalex.org/W2032776824', 'https://openalex.org/W2036903205', 'https://openalex.org/W2039506829', 'https://openalex.org/W2046399641', 'https://openalex.org/W2046718938', 'https://openalex.org/W2048445121', 'https://openalex.org/W2050615089', 'https://openalex.org/W2051582871', 'https://openalex.org/W2053135013', 'https://openalex.org/W2054992515', 'https://openalex.org/W2060570546', 'https://openalex.org/W2062855633', 'https://openalex.org/W2063450941', 'https://openalex.org/W2063473003', 'https://openalex.org/W2065128251', 'https://openalex.org/W2069353841', 'https://openalex.org/W2075358739', 'https://openalex.org/W2075793087', 'https://openalex.org/W2076061732', 'https://openalex.org/W2081829672', 'https://openalex.org/W2090182247', 'https://openalex.org/W2090480028', 'https://openalex.org/W2091787601', 'https://openalex.org/W2093026894', 'https://openalex.org/W2106620902', 'https://openalex.org/W2108242358', 'https://openalex.org/W2110305795', 'https://openalex.org/W2130386700', 'https://openalex.org/W2160064257', 'https://openalex.org/W2163512464', 'https://openalex.org/W2165937469', 'https://openalex.org/W2326885422', 'https://openalex.org/W2432179264', 'https://openalex.org/W3206570346', 'https://openalex.org/W4237468955', 'https://openalex.org/W4246157133'], 'related_works': ['https://openalex.org/W4235709349', 'https://openalex.org/W3139440102', 'https://openalex.org/W3136565871', 'https://openalex.org/W3040121704', 'https://openalex.org/W2765756599', 'https://openalex.org/W2238310462', 'https://openalex.org/W2141944437', 'https://openalex.org/W2068289873', 'https://openalex.org/W2042439225', 'https://openalex.org/W1973070150'], 'abstract_inverted_index': {'DNA': [0], 'replication': [1, 77], 'in': [2, 12, 31, 34, 45, 47, 75, 117, 124], 'mammals': [3], 'is': [4], 'temporally': [5], 'bimodal.': [6], '"Housekeeping"': [7], 'genes,': [8], 'which': [9, 35, 48, 118], 'are': [10, 37, 50, 112], 'active': [11], 'all': [13], 'cells,': [14], 'replicate': [15, 29, 43, 105], 'during': [16, 54, 97], 'the': [17, 21, 55, 59, 76, 86, 125], 'first': [18, 56], 'half': [19, 57], 'of': [20, 24, 58, 79, 88, 101], 'S': [22, 60], 'phase': [23, 61], 'cell': [25], 'growth.': [26], 'Tissue-specific': [27], 'genes': [28], 'early': [30, 107], 'those': [32], 'cells': [33], 'they': [36, 41, 49], 'potentially': [38], 'expressed,': [39], 'and': [40], 'usually': [42], 'late': [44], 'tissues': [46], 'not': [51, 67], 'expressed.': [52], 'Replication': [53], 'is,': [62], 'therefore,': [63], 'a': [64, 80, 115], 'necessary': [65], 'but': [66], 'sufficient': [68], 'condition': [69], 'for': [70], 'gene': [71, 82, 90], 'transcription.': [72], 'A': [73], 'change': [74], 'timing': [78], 'tissue-specific': [81], 'appears': [83], 'to': [84, 91, 95], 'reflect': [85], 'commitment': [87], 'that': [89], 'transcriptional': [92], 'competence': [93], 'or': [94, 108], 'quiescence': [96], 'ontogeny.': [98], 'Most': [99], 'families': [100], 'middle': [102], 'repetitive': [103], 'sequences': [104], 'either': [106], 'late.': [109], 'These': [110], 'data': [111], 'consistent': [113], 'with': [114], 'model': [116], 'two': [119], 'functionally': [120], 'distinct': [121], 'genomes': [122], 'coexist': [123], 'nucleus.': [126]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2053374394', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2025-01-07T02:05:35.421191', 'created_date': '2016-06-24'}