Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1973070150', 'doi': 'https://doi.org/10.1371/journal.pone.0114545', 'title': 'Initiation of DNA Replication from Non-Canonical Sites on an Origin-Depleted Chromosome', 'display_name': 'Initiation of DNA Replication from Non-Canonical Sites on an Origin-Depleted Chromosome', 'publication_year': 2014, 'publication_date': '2014-12-08', 'ids': {'openalex': 'https://openalex.org/W1973070150', 'doi': 'https://doi.org/10.1371/journal.pone.0114545', 'mag': '1973070150', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25486280', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/4259332'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0114545', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114545&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114545&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5059277535', 'display_name': 'Naomi L. Bogenschutz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}, {'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Naomi L. Bogenschutz', 'raw_affiliation_strings': ['Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America', 'Molecular and Cellular Biology Program, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Molecular and Cellular Biology Program, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America', 'institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I201448701']}, {'raw_affiliation_string': 'Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America', 'institution_ids': ['https://openalex.org/I4210089486']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018300539', 'display_name': 'Jairo Rodríguez', 'orcid': 'https://orcid.org/0000-0002-6844-974X'}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Jairo Rodriguez', 'raw_affiliation_strings': ['Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America', 'institution_ids': ['https://openalex.org/I4210089486']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5050815693', 'display_name': 'Toshio Tsukiyama', 'orcid': 'https://orcid.org/0000-0001-6478-6207'}, 'institutions': [{'id': 'https://openalex.org/I4210089486', 'display_name': 'Fred Hutch Cancer Center', 'ror': 'https://ror.org/007ps6h72', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210089486']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Toshio Tsukiyama', 'raw_affiliation_strings': ['Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America', 'institution_ids': ['https://openalex.org/I4210089486']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5059277535', 'https://openalex.org/A5018300539', 'https://openalex.org/A5050815693'], 'corresponding_institution_ids': ['https://openalex.org/I4210089486', 'https://openalex.org/I201448701', 'https://openalex.org/I4210089486', 'https://openalex.org/I4210089486'], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 0.783, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 23, 'citation_normalized_percentile': {'value': 0.795654, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '9', 'issue': '12', 'first_page': 'e114545', 'last_page': 'e114545'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'DNA Repair Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10497', 'display_name': 'Fungal and yeast genetics research', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pre-replication-complex', 'display_name': 'Pre-replication complex', 'score': 0.7393998}, {'id': 'https://openalex.org/keywords/origin-recognition-complex', 'display_name': 'Origin recognition complex', 'score': 0.69734913}, {'id': 'https://openalex.org/keywords/replication-timing', 'display_name': 'Replication timing', 'score': 0.67894715}, {'id': 'https://openalex.org/keywords/licensing-factor', 'display_name': 'Licensing factor', 'score': 0.6381454}, {'id': 'https://openalex.org/keywords/replication-factor-c', 'display_name': 'Replication factor C', 'score': 0.48382086}, {'id': 'https://openalex.org/keywords/autonomously-replicating-sequence', 'display_name': 'Autonomously replicating sequence', 'score': 0.45618194}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7506379}, {'id': 'https://openalex.org/C41141232', 'wikidata': 'https://www.wikidata.org/wiki/Q3685229', 'display_name': 'Pre-replication complex', 'level': 5, 'score': 0.7393998}, {'id': 'https://openalex.org/C58337764', 'wikidata': 'https://www.wikidata.org/wiki/Q976651', 'display_name': 'Origin of replication', 'level': 4, 'score': 0.72430104}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.6990522}, {'id': 'https://openalex.org/C151158763', 'wikidata': 'https://www.wikidata.org/wiki/Q1626856', 'display_name': 'Origin recognition complex', 'level': 5, 'score': 0.69734913}, {'id': 'https://openalex.org/C2778512757', 'wikidata': 'https://www.wikidata.org/wiki/Q7314076', 'display_name': 'Replication timing', 'level': 4, 'score': 0.67894715}, {'id': 'https://openalex.org/C104690221', 'wikidata': 'https://www.wikidata.org/wiki/Q5165872', 'display_name': 'Control of chromosome duplication', 'level': 4, 'score': 0.67782485}, {'id': 'https://openalex.org/C73573662', 'wikidata': 'https://www.wikidata.org/wiki/Q130996', 'display_name': 'DNA replication', 'level': 3, 'score': 0.67765856}, {'id': 'https://openalex.org/C54266558', 'wikidata': 'https://www.wikidata.org/wiki/Q6543075', 'display_name': 'Licensing factor', 'level': 5, 'score': 0.6381454}, {'id': 'https://openalex.org/C2777576037', 'wikidata': 'https://www.wikidata.org/wiki/Q719725', 'display_name': 'Saccharomyces cerevisiae', 'level': 3, 'score': 0.5254932}, {'id': 'https://openalex.org/C30481170', 'wikidata': 'https://www.wikidata.org/wiki/Q37748', 'display_name': 'Chromosome', 'level': 3, 'score': 0.51587594}, {'id': 'https://openalex.org/C188036394', 'wikidata': 'https://www.wikidata.org/wiki/Q14902224', 'display_name': 'Replication factor C', 'level': 5, 'score': 0.48382086}, {'id': 'https://openalex.org/C85638360', 'wikidata': 'https://www.wikidata.org/wiki/Q263090', 'display_name': 'Autonomously replicating sequence', 'level': 5, 'score': 0.45618194}, {'id': 'https://openalex.org/C98086919', 'wikidata': 'https://www.wikidata.org/wiki/Q118019', 'display_name': 'Eukaryotic DNA replication', 'level': 4, 'score': 0.45442513}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.3689764}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.21592417}], 'mesh': [{'descriptor_ui': 'D015825', 'descriptor_name': 'Chromosomes, Fungal', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004261', 'descriptor_name': 'DNA Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004271', 'descriptor_name': 'DNA, Fungal', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D051738', 'descriptor_name': 'Origin Recognition Complex', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D018741', 'descriptor_name': 'Replication Origin', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015825', 'descriptor_name': 'Chromosomes, Fungal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004271', 'descriptor_name': 'DNA, Fungal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051738', 'descriptor_name': 'Origin Recognition Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018741', 'descriptor_name': 'Replication Origin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0114545', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114545&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/205957aea46a4723a044d0c52aa93bc0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc4259332', 'pdf_url': 'https://europepmc.org/articles/pmc4259332?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259332', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25486280', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0114545', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0114545&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/15', 'score': 0.63, 'display_name': 'Life on land'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1514253368', 'https://openalex.org/W1519427546', 'https://openalex.org/W1850569493', 'https://openalex.org/W1865107886', 'https://openalex.org/W1966842178', 'https://openalex.org/W1978617734', 'https://openalex.org/W1988617470', 'https://openalex.org/W1993702002', 'https://openalex.org/W2003153093', 'https://openalex.org/W2008486131', 'https://openalex.org/W2010589044', 'https://openalex.org/W2034206561', 'https://openalex.org/W2037061918', 'https://openalex.org/W2050066600', 'https://openalex.org/W2060141490', 'https://openalex.org/W2080466240', 'https://openalex.org/W2084626008', 'https://openalex.org/W2105222529', 'https://openalex.org/W2106130068', 'https://openalex.org/W2111595310', 'https://openalex.org/W2112429774', 'https://openalex.org/W2118211036', 'https://openalex.org/W2123070316', 'https://openalex.org/W2125483272', 'https://openalex.org/W2126193015', 'https://openalex.org/W2126673769', 'https://openalex.org/W2129319315', 'https://openalex.org/W2134421533', 'https://openalex.org/W2137455320', 'https://openalex.org/W2148990865', 'https://openalex.org/W2164235180', 'https://openalex.org/W2166459599', 'https://openalex.org/W4253634538'], 'related_works': ['https://openalex.org/W4235709349', 'https://openalex.org/W2417440641', 'https://openalex.org/W2163245344', 'https://openalex.org/W2158990839', 'https://openalex.org/W2156911227', 'https://openalex.org/W2141944437', 'https://openalex.org/W2125404920', 'https://openalex.org/W1994187913', 'https://openalex.org/W1973070150', 'https://openalex.org/W1970873235'], 'abstract_inverted_index': {'Eukaryotic': [0], 'DNA': [1, 137], 'replication': [2, 11, 49, 77, 108, 130, 138, 152], 'initiates': [3, 139], 'from': [4, 89, 140], 'multiple': [5, 58], 'sites': [6], 'on': [7], 'each': [8], 'chromosome': [9, 55, 73, 90, 134], 'called': [10], 'origins': [12, 20, 33, 88, 145], '(origins).': [13], 'In': [14], 'the': [15, 46, 105, 113, 122, 125], 'budding': [16], 'yeast': [17], 'Saccharomyces': [18], 'cerevisiae,': [19], 'are': [21, 34], 'defined': [22], 'at': [23], 'discrete': [24], 'sites.': [25], 'Regular': [26], 'spacing': [27], 'and': [28, 68, 92], 'diverse': [29], 'firing': [30], 'characteristics': [31], 'of': [32, 42, 48, 107, 124, 132], 'thought': [35], 'to': [36, 64], 'be': [37, 155], 'required': [38], 'for': [39], 'efficient': [40], 'completion': [41], 'replication,': [43], 'especially': [44], 'in': [45, 104, 121, 146, 158], 'presence': [47, 106], 'stress.': [50], 'However,': [51], 'a': [52, 118], 'S.': [53], 'cerevisiae': [54], 'III': [56], 'harboring': [57], 'origin': [59, 114, 126], 'deletions': [60, 96, 115], 'has': [61], 'been': [62], 'reported': [63], 'replicate': [65], 'relatively': [66], 'normally,': [67], 'yet': [69], 'how': [70], 'an': [71], 'origin-deficient': [72], 'could': [74], 'accomplish': [75], 'successful': [76], 'remains': [78], 'unknown.': [79], 'To': [80], 'address': [81], 'this': [82, 133, 159], 'issue,': [83], 'we': [84], 'deleted': [85, 144], 'seven': [86], 'well-characterized': [87], 'VI,': [91], 'found': [93], 'that': [94, 112, 136, 151], 'these': [95], 'do': [97, 116], 'not': [98], 'cause': [99, 117], 'gross': [100], 'growth': [101], 'defects': [102], 'even': [103], 'inhibitors.': [109], 'We': [110], 'demonstrated': [111], 'strong': [119], 'decrease': [120], 'binding': [123], 'recognition': [127], 'complex.': [128], 'Unexpectedly,': [129], 'profiling': [131], 'showed': [135], 'non-canonical': [141], 'loci': [142], 'around': [143], 'yeast.': [147], 'These': [148], 'results': [149], 'suggest': [150], 'initiation': [153], 'can': [154], 'unexpectedly': [156], 'flexible': [157], 'organism.': [160]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1973070150', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2025-01-09T08:41:17.145910', 'created_date': '2016-06-24'}