Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2051551600', 'doi': 'https://doi.org/10.1034/j.1600-0749.13.s8.28.x', 'title': 'The Melanocortin‐1 Receptor is a Key Regulator of Human Cutaneous Pigmentation', 'display_name': 'The Melanocortin‐1 Receptor is a Key Regulator of Human Cutaneous Pigmentation', 'publication_year': 2000, 'publication_date': '2000-06-01', 'ids': {'openalex': 'https://openalex.org/W2051551600', 'doi': 'https://doi.org/10.1034/j.1600-0749.13.s8.28.x', 'mag': '2051551600', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11041375'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1034/j.1600-0749.13.s8.28.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S180366410', 'display_name': 'Pigment Cell Research', 'issn_l': '0893-5785', 'issn': ['0893-5785', '1600-0749'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5078700708', 'display_name': 'ZALFA ABDEL‐MALEK', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I63135867', 'display_name': 'University of Cincinnati', 'ror': 'https://ror.org/01e3m7079', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63135867']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'ZALFA ABDEL‐MALEK', 'raw_affiliation_strings': ['University of Cincinnati, Ohio, 45267-592, USA.'], 'affiliations': [{'raw_affiliation_string': 'University of Cincinnati, Ohio, 45267-592, USA.', 'institution_ids': ['https://openalex.org/I63135867']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026588554', 'display_name': 'Matt Scott', 'orcid': 'https://orcid.org/0000-0002-8859-4602'}, 'institutions': [{'id': 'https://openalex.org/I63135867', 'display_name': 'University of Cincinnati', 'ror': 'https://ror.org/01e3m7079', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I63135867']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'M. CATHY SCOTT', 'raw_affiliation_strings': ['University of Cincinnati, Ohio, 45267-592, USA.'], 'affiliations': [{'raw_affiliation_string': 'University of Cincinnati, Ohio, 45267-592, USA.', 'institution_ids': ['https://openalex.org/I63135867']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050331345', 'display_name': 'Itaru Suzuki', 'orcid': 'https://orcid.org/0000-0002-4817-9156'}, 'institutions': [{'id': 'https://openalex.org/I4210111113', 'display_name': 'Pola Chemical Industries (Japan)', 'ror': 'https://ror.org/021gh4f04', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210111113']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'ITARU SUZUKI', 'raw_affiliation_strings': ['POLA Laboratories, Yokohama, 244 Japan'], 'affiliations': [{'raw_affiliation_string': 'POLA Laboratories, Yokohama, 244 Japan', 'institution_ids': ['https://openalex.org/I4210111113']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112047011', 'display_name': 'Akihiro Tada', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210111113', 'display_name': 'Pola Chemical Industries (Japan)', 'ror': 'https://ror.org/021gh4f04', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210111113']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'AKIHIRO TADA', 'raw_affiliation_strings': ['POLA Laboratories, Yokohama, 244 Japan'], 'affiliations': [{'raw_affiliation_string': 'POLA Laboratories, Yokohama, 244 Japan', 'institution_ids': ['https://openalex.org/I4210111113']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102136012', 'display_name': 'Sungbin Im', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I57664883', 'display_name': 'Ajou University', 'ror': 'https://ror.org/03tzb2h73', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I57664883']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'SUNGBIN IM', 'raw_affiliation_strings': ['Ajou University 442-749, Korea#TAB#'], 'affiliations': [{'raw_affiliation_string': 'Ajou University 442-749, Korea#TAB#', 'institution_ids': ['https://openalex.org/I57664883']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030119049', 'display_name': 'Lynn Lamoreux', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I91045830', 'display_name': 'Texas A&M University', 'ror': 'https://ror.org/01f5ytq51', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I91045830']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'LYNN LAMOREUX', 'raw_affiliation_strings': ['Texas A&M University, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'Texas A&M University, Texas, USA', 'institution_ids': ['https://openalex.org/I91045830']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065973944', 'display_name': 'Shosuke Ito', 'orcid': 'https://orcid.org/0000-0001-9182-5144'}, 'institutions': [{'id': 'https://openalex.org/I145673806', 'display_name': 'Fujita Health University', 'ror': 'https://ror.org/046f6cx68', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I145673806']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'SHOSUKE ITO', 'raw_affiliation_strings': ['FUJITA HEALTH UNIVERSITY, Toyoake, Japan'], 'affiliations': [{'raw_affiliation_string': 'FUJITA HEALTH UNIVERSITY, Toyoake, Japan', 'institution_ids': ['https://openalex.org/I145673806']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033517921', 'display_name': 'Gregory S. Barsh', 'orcid': 'https://orcid.org/0000-0002-0838-1042'}, 'institutions': [{'id': 'https://openalex.org/I97018004', 'display_name': 'Stanford University', 'ror': 'https://ror.org/00f54p054', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I97018004']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'GREG BARSH', 'raw_affiliation_strings': ['Stanford University, California, USA#TAB#'], 'affiliations': [{'raw_affiliation_string': 'Stanford University, California, USA#TAB#', 'institution_ids': ['https://openalex.org/I97018004']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5107446295', 'display_name': 'Vincent J. Hearing', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210140884', 'display_name': 'National Cancer Institute', 'ror': 'https://ror.org/040gcmg81', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210140884']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'VINCENT J. HEARING', 'raw_affiliation_strings': ['National Cancer Institute, Maryland, USA'], 'affiliations': [{'raw_affiliation_string': 'National Cancer Institute, Maryland, USA', 'institution_ids': ['https://openalex.org/I4210140884']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.222, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 133, 'citation_normalized_percentile': {'value': 0.944536, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '13', 'issue': 's8', 'first_page': '156', 'last_page': '162'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11144', 'display_name': 'melanin and skin pigmentation', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11144', 'display_name': 'melanin and skin pigmentation', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11584', 'display_name': 'Biochemical Analysis and Sensing Techniques', 'score': 0.9897, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10489', 'display_name': 'Regulation of Appetite and Obesity', 'score': 0.9626, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/melanocortin-1-receptor', 'display_name': 'Melanocortin 1 receptor', 'score': 0.9463901}, {'id': 'https://openalex.org/keywords/melanocortins', 'display_name': 'Melanocortins', 'score': 0.9415271}, {'id': 'https://openalex.org/keywords/melanocyte', 'display_name': 'Melanocyte', 'score': 0.7487985}, {'id': 'https://openalex.org/keywords/melanocyte-stimulating-hormone', 'display_name': 'Melanocyte-stimulating hormone', 'score': 0.6732842}, {'id': 'https://openalex.org/keywords/human-skin', 'display_name': 'Human skin', 'score': 0.4998269}], 'concepts': [{'id': 'https://openalex.org/C182843373', 'wikidata': 'https://www.wikidata.org/wiki/Q21173746', 'display_name': 'Melanocortin 1 receptor', 'level': 4, 'score': 0.9463901}, {'id': 'https://openalex.org/C2909567013', 'wikidata': 'https://www.wikidata.org/wiki/Q6591465', 'display_name': 'Melanocortins', 'level': 4, 'score': 0.9415271}, {'id': 'https://openalex.org/C2779993316', 'wikidata': 'https://www.wikidata.org/wiki/Q6591465', 'display_name': 'Melanocortin', 'level': 3, 'score': 0.87029135}, {'id': 'https://openalex.org/C2779769559', 'wikidata': 'https://www.wikidata.org/wiki/Q247101', 'display_name': 'Melanocyte', 'level': 3, 'score': 0.7487985}, {'id': 'https://openalex.org/C2780989459', 'wikidata': 'https://www.wikidata.org/wiki/Q423981', 'display_name': 'Melanocyte-stimulating hormone', 'level': 3, 'score': 0.6732842}, {'id': 'https://openalex.org/C2777241137', 'wikidata': 'https://www.wikidata.org/wiki/Q24784850', 'display_name': 'Melanocortin receptor', 'level': 4, 'score': 0.6232506}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.62061846}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6204835}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.5568705}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5402339}, {'id': 'https://openalex.org/C2777459323', 'wikidata': 'https://www.wikidata.org/wiki/Q5259911', 'display_name': 'Human skin', 'level': 2, 'score': 0.4998269}, {'id': 'https://openalex.org/C501734568', 'wikidata': 'https://www.wikidata.org/wiki/Q42918', 'display_name': 'Mutation', 'level': 3, 'score': 0.41743708}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.32256645}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.3070558}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.20931494}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.16977197}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.1017783}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.08238527}, {'id': 'https://openalex.org/C2777658100', 'wikidata': 'https://www.wikidata.org/wiki/Q180614', 'display_name': 'Melanoma', 'level': 2, 'score': 0.057445258}], 'mesh': [{'descriptor_ui': 'D036341', 'descriptor_name': 'Intercellular Signaling Peptides and Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018043', 'descriptor_name': 'Receptors, Corticotropin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D012880', 'descriptor_name': 'Skin Pigmentation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D054366', 'descriptor_name': 'Agouti Signaling Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008543', 'descriptor_name': 'Melanins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008543', 'descriptor_name': 'Melanins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008544', 'descriptor_name': 'Melanocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008544', 'descriptor_name': 'Melanocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011333', 'descriptor_name': 'Pro-Opiomelanocortin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011333', 'descriptor_name': 'Pro-Opiomelanocortin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018043', 'descriptor_name': 'Receptors, Corticotropin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044101', 'descriptor_name': 'Receptors, Melanocortin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012880', 'descriptor_name': 'Skin Pigmentation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000521', 'descriptor_name': 'alpha-MSH', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000521', 'descriptor_name': 'alpha-MSH', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1034/j.1600-0749.13.s8.28.x', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S180366410', 'display_name': 'Pigment Cell Research', 'issn_l': '0893-5785', 'issn': ['0893-5785', '1600-0749'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11041375', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W69973889', 'https://openalex.org/W3193531443', 'https://openalex.org/W2517562016', 'https://openalex.org/W2089588566', 'https://openalex.org/W2076809379', 'https://openalex.org/W2054435056', 'https://openalex.org/W2051551600', 'https://openalex.org/W2005763012', 'https://openalex.org/W1965504359', 'https://openalex.org/W125181801'], 'abstract_inverted_index': {'The': [0, 100], 'cloning': [1], 'and': [2, 10, 25, 32, 57, 66, 72, 131, 138, 154, 192, 266], 'characterization': [3], 'of': [4, 45, 84, 93, 107, 111, 119, 148, 157, 163, 239, 245, 253, 261], 'the': [5, 11, 19, 43, 60, 82, 85, 90, 104, 108, 120, 146, 155, 161, 164, 167, 176, 209, 237, 243, 246, 251, 259], 'human': [6, 15, 49, 61, 76, 94, 152], 'melanocortin-1': [7], 'receptor': [8], '(MC1R)': [9], 'demonstration': [12], 'that': [13, 55, 81, 142, 219], 'normal': [14, 213], 'melanocytes': [16, 95, 153, 170, 262], 'respond': [17], 'to': [18, 38, 96, 124, 183, 190, 198, 215, 235, 263], 'melanocortins,': [20, 264], 'alpha-melanocyte': [21], 'stimulating': [22], 'hormone': [23, 27], '(alpha-MSH)': [24], 'adrenocorticotrophic': [26], '(ACTH),': [28], 'with': [29, 63], 'increased': [30], 'proliferation': [31], 'eumelanogenesis': [33], 'had': [34], 'put': [35], 'an': [36, 194], 'end': [37], 'a': [39, 179, 212, 254], 'long-standing': [40], 'controversy': [41], 'about': [42], 'role': [44], 'melanocortins': [46], 'in': [47, 69, 175, 208, 223, 242, 258], 'regulating': [48], 'cutaneous': [50], 'pigmentation.': [51], 'We': [52, 78], 'have': [53], 'shown': [54], 'alpha-MSH': [56, 130], 'ACTH': [58], 'bind': [59], 'MC1R': [62, 86, 101, 121, 149, 165, 177, 230, 240, 257], 'equal': [64], 'affinity,': [65], 'are': [67, 220], 'equipotent': [68], 'their': [70], 'mitogenic': [71], 'melanogenic': [73, 91], 'effects': [74, 110], 'on': [75, 116, 145, 160], 'melanocytes.': [77], 'also': [79, 103], 'showed': [80], 'activation': [83], 'is': [87, 102, 122], 'important': [88], 'for': [89, 172, 205], 'response': [92, 182, 197, 214, 260], 'ultraviolet': [97], 'radiation': [98], '(UVR).': [99], 'principal': [105], 'mediator': [106], 'inhibitory': [109], 'agouti': [112], 'signaling': [113], 'protein': [114], '(ASP)': [115], 'melanogenesis.': [117], 'Expression': [118], 'subject': [123], 'regulation': [125], 'by': [126, 136, 151], 'its': [127], 'own': [128], 'ligands': [129], 'ACTH,': [132], 'as': [133, 135], 'well': [134], 'UVR': [137], 'endothelin-1.': [139], 'Recent': [140], 'studies': [141], 'we': [143], 'conducted': [144], 'expression': [147], 'variants': [150, 159, 241], 'implications': [156], 'these': [158], 'function': [162, 244], 'revealed': [166], 'following.': [168], 'Human': [169], 'homozygous': [171, 204], 'Arg160Trp': [173], 'mutation': [174, 207], 'demonstrated': [178, 211], 'significantly': [180], 'reduced': [181], 'alpha-MSH.': [184, 216], 'Also,': [185], 'this': [186], 'culture': [187], 'responded': [188], 'poorly': [189], 'ASP': [191], 'exhibited': [193], 'exaggerated': [195], 'cytotoxic': [196], 'UVR.': [199, 267], 'Another': [200], 'culture,': [201], 'which': [202], 'was': [203], 'Val92Met': [206], 'MC1R,': [210], 'Heterozygous': [217], 'mutations': [218], 'frequently': [221], 'expressed': [222], 'various': [224], 'melanocyte': [225], 'cultures': [226], 'did': [227], 'not': [228], 'disrupt': [229], 'function.': [231], 'These': [232], 'results': [233], 'begin': [234], 'elucidate': [236], 'significance': [238, 252], 'receptor.': [247], 'Our': [248], 'data': [249], 'emphasize': [250], 'normally': [255], 'functioning': [256], 'ASP,': [265]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2051551600', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 10}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2025-01-05T22:45:46.490628', 'created_date': '2016-06-24'}