Title: Global Left Atrial Strain Correlates with CHADS2 Risk Score in Patients with Atrial Fibrillation
Abstract: <h3>Background</h3> The aim of this cross-sectional study was to explore the association between echocardiographic parameters and CHADS<sub>2</sub> score in patients with nonvalvular atrial fibrillation (AF). <h3>Methods</h3> Seventy-seven subjects (36 patients with AF, 41 control subjects) underwent standard two-dimensional, Doppler, and speckle-tracking echocardiography to compute regional and global left atrial (LA) strain. <h3>Results</h3> Global longitudinal LA strain was reduced in patients with AF compared with controls (<i>P</i> < .001) and was a predictor of high risk for thromboembolism (CHADS<sub>2</sub> score ≥ 2; odds ratio, 0.86; <i>P</i> = .02). LA strain indexes showed good interobserver and intraobserver variability. In sequential Cox models, the prediction of hospitalization and/or death was improved by addition of global LA strain and indexed LA volume to CHADS<sub>2</sub> score (<i>P</i> = .003). <h3>Conclusions</h3> LA strain is a reproducible marker of dynamic LA function and a predictor of stroke risk and cardiovascular outcomes in patients with AF.
Publication Year: 2011
Publication Date: 2011-04-15
Language: en
Type: letter
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 114
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