Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2049904086', 'doi': 'https://doi.org/10.1161/01.cir.0000141574.78032.a9', 'title': 'Improved Vascular Gene Transfer With a Helper-Dependent Adenoviral Vector', 'display_name': 'Improved Vascular Gene Transfer With a Helper-Dependent Adenoviral Vector', 'publication_year': 2004, 'publication_date': '2004-09-14', 'ids': {'openalex': 'https://openalex.org/W2049904086', 'doi': 'https://doi.org/10.1161/01.cir.0000141574.78032.a9', 'mag': '2049904086', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15326058'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.cir.0000141574.78032.a9', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000141574.78032.A9', 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000141574.78032.A9', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002435665', 'display_name': 'Shan Wen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shan Wen', 'raw_affiliation_strings': ['From the Department of Medicine, University of Washington, Seattle.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, University of Washington, Seattle.', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030617595', 'display_name': 'Shannon Graf', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shannon Graf', 'raw_affiliation_strings': ['From the Department of Medicine, University of Washington, Seattle.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, University of Washington, Seattle.', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048902051', 'display_name': 'Philip G. Massey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Philip G. Massey', 'raw_affiliation_strings': ['From the Department of Medicine, University of Washington, Seattle.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, University of Washington, Seattle.', 'institution_ids': ['https://openalex.org/I201448701']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009396539', 'display_name': 'David A. Dichek', 'orcid': 'https://orcid.org/0000-0002-5224-2736'}, 'institutions': [{'id': 'https://openalex.org/I201448701', 'display_name': 'University of Washington', 'ror': 'https://ror.org/00cvxb145', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I201448701']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David A. Dichek', 'raw_affiliation_strings': ['From the Department of Medicine, University of Washington, Seattle.'], 'affiliations': [{'raw_affiliation_string': 'From the Department of Medicine, University of Washington, Seattle.', 'institution_ids': ['https://openalex.org/I201448701']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.804, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 57, 'citation_normalized_percentile': {'value': 0.927413, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '110', 'issue': '11', 'first_page': '1484', 'last_page': '1491'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10613', 'display_name': 'Gene Therapy Techniques and Applications', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10613', 'display_name': 'Gene Therapy Techniques and Applications', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10729', 'display_name': 'Electrospun Nanofibers in Biomedical Applications', 'score': 0.9895, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lentiviral-vector', 'display_name': 'Lentiviral Vector', 'score': 0.510653}], 'concepts': [{'id': 'https://openalex.org/C111599444', 'wikidata': 'https://www.wikidata.org/wiki/Q213901', 'display_name': 'Genetic enhancement', 'level': 3, 'score': 0.74053824}, {'id': 'https://openalex.org/C32470452', 'wikidata': 'https://www.wikidata.org/wiki/Q2298489', 'display_name': 'Viral vector', 'level': 4, 'score': 0.69318825}, {'id': 'https://openalex.org/C2776954459', 'wikidata': 'https://www.wikidata.org/wiki/Q193447', 'display_name': 'Adenoviridae', 'level': 4, 'score': 0.56862307}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.5665008}, {'id': 'https://openalex.org/C2779395532', 'wikidata': 'https://www.wikidata.org/wiki/Q7916469', 'display_name': 'Vascular smooth muscle', 'level': 3, 'score': 0.4765675}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.4540064}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4440357}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.43911776}, {'id': 'https://openalex.org/C92087593', 'wikidata': 'https://www.wikidata.org/wiki/Q427389', 'display_name': 'Vector (molecular biology)', 'level': 4, 'score': 0.42334908}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.37046114}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.34067687}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.33567297}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33257478}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.2984832}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.17469442}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2992686903', 'wikidata': 'https://www.wikidata.org/wiki/Q208453', 'display_name': 'Smooth muscle', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000256', 'descriptor_name': 'Adenoviridae', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D003673', 'descriptor_name': 'Defective Viruses', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D006378', 'descriptor_name': 'Helper Viruses', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014161', 'descriptor_name': 'Transduction, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D014568', 'descriptor_name': 'Urokinase-Type Plasminogen Activator', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000256', 'descriptor_name': 'Adenoviridae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000256', 'descriptor_name': 'Adenoviridae', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D017498', 'descriptor_name': 'Adenovirus E1 Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017498', 'descriptor_name': 'Adenovirus E1 Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017498', 'descriptor_name': 'Adenovirus E1 Proteins', 'qualifier_ui': 'Q000172', 'qualifier_name': 'deficiency', 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000914', 'descriptor_name': 'Antibodies, Viral', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000914', 'descriptor_name': 'Antibodies, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000914', 'descriptor_name': 'Antibodies, Viral', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D002213', 'descriptor_name': 'Capsid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002213', 'descriptor_name': 'Capsid', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D002339', 'descriptor_name': 'Carotid Arteries', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D003587', 'descriptor_name': 'Cytomegalovirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003587', 'descriptor_name': 'Cytomegalovirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003673', 'descriptor_name': 'Defective Viruses', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042783', 'descriptor_name': 'Endothelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042783', 'descriptor_name': 'Endothelial Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D042783', 'descriptor_name': 'Endothelial Cells', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004730', 'descriptor_name': 'Endothelium, Vascular', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005813', 'descriptor_name': 'Genes, Synthetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D006378', 'descriptor_name': 'Helper Viruses', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006965', 'descriptor_name': 'Hyperplasia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007267', 'descriptor_name': 'Injections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011817', 'descriptor_name': 'Rabbits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019076', 'descriptor_name': 'Transgenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017539', 'descriptor_name': 'Tunica Intima', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017539', 'descriptor_name': 'Tunica Intima', 'qualifier_ui': 'Q000648', 'qualifier_name': 'ultrastructure', 'is_major_topic': False}, {'descriptor_ui': 'D014568', 'descriptor_name': 'Urokinase-Type Plasminogen Activator', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014568', 'descriptor_name': 'Urokinase-Type Plasminogen Activator', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D019010', 'descriptor_name': 'Vascular Cell Adhesion Molecule-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019010', 'descriptor_name': 'Vascular Cell Adhesion Molecule-1', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D014657', 'descriptor_name': 'Vasculitis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014657', 'descriptor_name': 'Vasculitis', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D014657', 'descriptor_name': 'Vasculitis', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.cir.0000141574.78032.a9', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000141574.78032.A9', 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15326058', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1161/01.cir.0000141574.78032.a9', 'pdf_url': 'https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.0000141574.78032.A9', 'source': {'id': 'https://openalex.org/S116251202', 'display_name': 'Circulation', 'issn_l': '0009-7322', 'issn': ['0009-7322', '1524-4539'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.74}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 40, 'referenced_works': ['https://openalex.org/W1965172479', 'https://openalex.org/W1965518509', 'https://openalex.org/W1990561446', 'https://openalex.org/W2004646325', 'https://openalex.org/W2008336445', 'https://openalex.org/W2016200465', 'https://openalex.org/W2033131186', 'https://openalex.org/W2035600956', 'https://openalex.org/W2046906164', 'https://openalex.org/W2052612816', 'https://openalex.org/W2065853857', 'https://openalex.org/W2068161230', 'https://openalex.org/W2075921029', 'https://openalex.org/W2078396087', 'https://openalex.org/W2081484258', 'https://openalex.org/W2081738353', 'https://openalex.org/W2084015000', 'https://openalex.org/W2085041477', 'https://openalex.org/W2087080914', 'https://openalex.org/W2091899397', 'https://openalex.org/W2097132418', 'https://openalex.org/W2097187941', 'https://openalex.org/W2098264302', 'https://openalex.org/W2102608915', 'https://openalex.org/W2107021343', 'https://openalex.org/W2110014354', 'https://openalex.org/W2118479681', 'https://openalex.org/W2125781030', 'https://openalex.org/W2131095976', 'https://openalex.org/W2137474914', 'https://openalex.org/W2144217904', 'https://openalex.org/W2145242239', 'https://openalex.org/W2155898643', 'https://openalex.org/W2158319858', 'https://openalex.org/W2163267480', 'https://openalex.org/W2163457814', 'https://openalex.org/W2169662267', 'https://openalex.org/W2322836356', 'https://openalex.org/W2324841714', 'https://openalex.org/W2460396814'], 'related_works': ['https://openalex.org/W4236631617', 'https://openalex.org/W4230010807', 'https://openalex.org/W3032277478', 'https://openalex.org/W2394205039', 'https://openalex.org/W2374090291', 'https://openalex.org/W2347300262', 'https://openalex.org/W2046944129', 'https://openalex.org/W1996824302', 'https://openalex.org/W181974884', 'https://openalex.org/W1587611090'], 'abstract_inverted_index': {'Background—': [0], 'Adenoviral': [1], 'vectors': [2, 18, 43, 202, 222], 'are': [3], 'the': [4, 14, 31, 210], 'most': [5], 'widely': [6], 'used': [7], 'agents': [8, 226], 'for': [9, 19, 64, 160, 213, 227], 'vascular': [10, 20, 65, 123, 211, 228], 'gene': [11, 21, 48, 66, 92, 119, 133, 208, 229, 232], 'transfer.': [12, 67, 120, 134], 'However,': [13], 'utility': [15], 'of': [16, 27, 33, 90, 182], 'adenoviral': [17, 42, 75, 201, 221], 'transfer': [22, 230], 'is': [23], 'limited': [24], 'by': [25, 30, 179], 'brevity': [26], 'expression': [28, 49, 104, 136, 152, 165, 173], 'and': [29, 52, 69, 105, 125, 139, 153, 193, 231], 'induction': [32], 'a': [34, 73, 87, 95, 206], 'significant': [35], 'host': [36], 'inflammatory': [37], 'response.': [38], 'Third-generation': [39], 'or': [40], '“helper-dependent”': [41], 'have': [44, 60], 'achieved': [45], 'prolonged': [46], 'recombinant': [47], 'in': [50, 86, 110, 144, 157, 174, 209], 'liver': [51], 'muscle': [53], 'with': [54, 94, 147, 163, 216], 'minimal': [55, 217], 'associated': [56, 218], 'inflammation;': [57], 'however,': [58], 'they': [59], 'never': [61], 'been': [62], 'tested': [63], 'Methods': [68], 'Results—': [70], 'We': [71], 'constructed': [72], 'helper-dependent': [74], 'vector': [76, 106, 140, 154], 'expressing': [77, 99], 'rabbit': [78, 88, 100], 'urokinase': [79], 'plasminogen': [80], 'activator': [81], '(HD-AduPA).': [82], 'HD-AduPA': [83, 158, 175, 187], 'was': [84, 137, 177], 'compared,': [85], 'model': [89], 'carotid': [91], 'transfer,': [93], 'first-generation': [96], 'adenovirus,': [97], 'also': [98], 'uPA': [101, 103, 135, 151, 172, 184], '(FG-AduPA).': [102], 'DNA': [107, 141, 155], 'were': [108, 128], 'measured': [109], 'arteries': [111, 145, 159, 176, 188], 'harvested': [112], 'from': [113, 166], '3': [114], 'to': [115, 168], '56': [116, 169], 'days': [117, 131], 'after': [118, 132], 'Vector-specific': [121], 'mRNA,': [122], 'inflammation,': [124], 'neointimal': [126, 194], 'formation': [127, 195], 'assessed': [129], '14': [130, 167], 'lost,': [138], 'declined': [142], 'rapidly': [143], 'infused': [146], 'FG-AduPA.': [148], 'In': [149], 'contrast,': [150], 'persisted': [156], '≥56': [161], 'days,': [162], 'stable': [164], 'days.': [170], 'Increased': [171], 'accompanied': [178], 'high': [180], 'levels': [181], 'vector-specific': [183], 'mRNA.': [185], 'Moreover,': [186], 'had': [189], 'significantly': [190], 'less': [191], 'inflammation': [192], 'than': [196], 'FG-AduPA': [197], 'arteries.': [198], 'Conclusions—': [199], 'Helper-dependent': [200, 220], 'can': [203], 'stably': [204], 'express': [205], 'therapeutic': [207], 'wall': [212], '≥8': [214], 'weeks,': [215], 'inflammation.': [219], 'will': [223], 'be': [224], 'useful': [225], 'therapy.': [233]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2049904086', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-09-09T13:05:59.997363', 'created_date': '2016-06-24'}