Title: Effect of protamine on heparin-antithrombin III complexes. In vitro studies
Abstract: In vitro, when protamine sulfate (salmine) is added to heparinized human plasma, the activated heparin-antithrombin III complex which had been formed is broken, freeing the antithrombin and reestablishing its slowly progressive antithrombin activity. The “freed” antithrombin can be reactivated to an immediate inhibitor of thrombin by the addition of excess heparin to the “neutralized” plasma. In its interaction with commercial porcine mucosal heparin, protamine forms complexes only with the higher molecular weight, biologically active fractions of the heparin.
Publication Year: 1980
Publication Date: 1980-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 28
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