Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2047835909', 'doi': 'https://doi.org/10.1210/jc.2009-2561', 'title': 'Prolonged Inactivity Up-Regulates Cholesteryl Ester Transfer Protein Independently of Body Fat Changes in Humans', 'display_name': 'Prolonged Inactivity Up-Regulates Cholesteryl Ester Transfer Protein Independently of Body Fat Changes in Humans', 'publication_year': 2010, 'publication_date': '2010-03-13', 'ids': {'openalex': 'https://openalex.org/W2047835909', 'doi': 'https://doi.org/10.1210/jc.2009-2561', 'mag': '2047835909', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20228163'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/jc.2009-2561', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205775358', 'display_name': 'The Journal of Clinical Endocrinology & Metabolism', 'issn_l': '0021-972X', 'issn': ['0021-972X', '1945-7197'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1210/jc.2009-2561', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5034585696', 'display_name': 'Sara Mazzucco', 'orcid': 'https://orcid.org/0000-0002-1582-6724'}, 'institutions': [{'id': 'https://openalex.org/I142444530', 'display_name': 'University of Trieste', 'ror': 'https://ror.org/02n742c10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I142444530']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Sara Mazzucco', 'raw_affiliation_strings': ['Department of Medical, Technological, and Translational Science, Division of Internal Medicine, University of Trieste, 34139 Trieste, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical, Technological, and Translational Science, Division of Internal Medicine, University of Trieste, 34139 Trieste, Italy.', 'institution_ids': ['https://openalex.org/I142444530']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080140748', 'display_name': 'Francesco Agostini', 'orcid': 'https://orcid.org/0000-0002-2808-9348'}, 'institutions': [{'id': 'https://openalex.org/I142444530', 'display_name': 'University of Trieste', 'ror': 'https://ror.org/02n742c10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I142444530']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Francesco Agostini', 'raw_affiliation_strings': ['Department of Medical, Technological, and Translational Science, Division of Internal Medicine, University of Trieste, 34139 Trieste, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical, Technological, and Translational Science, Division of Internal Medicine, University of Trieste, 34139 Trieste, Italy.', 'institution_ids': ['https://openalex.org/I142444530']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091777805', 'display_name': 'Alessandro Mangogna', 'orcid': 'https://orcid.org/0000-0001-7910-1274'}, 'institutions': [{'id': 'https://openalex.org/I142444530', 'display_name': 'University of Trieste', 'ror': 'https://ror.org/02n742c10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I142444530']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Alessandro Mangogna', 'raw_affiliation_strings': ['Department of Medical, Technological, and Translational Science, Division of Internal Medicine, University of Trieste, 34139 Trieste, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical, Technological, and Translational Science, Division of Internal Medicine, University of Trieste, 34139 Trieste, Italy.', 'institution_ids': ['https://openalex.org/I142444530']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057717851', 'display_name': 'Luigi Cattin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I142444530', 'display_name': 'University of Trieste', 'ror': 'https://ror.org/02n742c10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I142444530']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Luigi Cattin', 'raw_affiliation_strings': ['Department of Medical, Technological, and Translational Science, Division of Internal Medicine, University of Trieste, 34139 Trieste, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical, Technological, and Translational Science, Division of Internal Medicine, University of Trieste, 34139 Trieste, Italy.', 'institution_ids': ['https://openalex.org/I142444530']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5081926215', 'display_name': 'Gianni Biolo', 'orcid': 'https://orcid.org/0000-0002-6397-1598'}, 'institutions': [{'id': 'https://openalex.org/I142444530', 'display_name': 'University of Trieste', 'ror': 'https://ror.org/02n742c10', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I142444530']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Gianni Biolo', 'raw_affiliation_strings': ['Department of Medical, Technological, and Translational Science, Division of Internal Medicine, University of Trieste, 34139 Trieste, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical, Technological, and Translational Science, Division of Internal Medicine, University of Trieste, 34139 Trieste, Italy.', 'institution_ids': ['https://openalex.org/I142444530']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.393, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.848742, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '95', 'issue': '5', 'first_page': '2508', 'last_page': '2512'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11399', 'display_name': 'Muscle metabolism and nutrition', 'score': 0.9936, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11399', 'display_name': 'Muscle metabolism and nutrition', 'score': 0.9936, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11209', 'display_name': 'Cardiovascular and exercise physiology', 'score': 0.9777, 'subfield': {'id': 'https://openalex.org/subfields/2707', 'display_name': 'Complementary and alternative medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10397', 'display_name': 'Nutrition and Health in Aging', 'score': 0.9731, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cholesterylester-transfer-protein', 'display_name': 'Cholesterylester transfer protein', 'score': 0.89376837}, {'id': 'https://openalex.org/keywords/reverse-cholesterol-transport', 'display_name': 'Reverse cholesterol transport', 'score': 0.52885044}, {'id': 'https://openalex.org/keywords/high-density-lipoprotein', 'display_name': 'High-density lipoprotein', 'score': 0.47706735}, {'id': 'https://openalex.org/keywords/cholesteryl-ester', 'display_name': 'Cholesteryl ester', 'score': 0.4403548}], 'concepts': [{'id': 'https://openalex.org/C45505151', 'wikidata': 'https://www.wikidata.org/wiki/Q424706', 'display_name': 'Cholesterylester transfer protein', 'level': 4, 'score': 0.89376837}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.8064187}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.79410064}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.6870645}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6321041}, {'id': 'https://openalex.org/C2777391703', 'wikidata': 'https://www.wikidata.org/wiki/Q1053470', 'display_name': 'Insulin resistance', 'level': 3, 'score': 0.62872493}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.54297686}, {'id': 'https://openalex.org/C110459506', 'wikidata': 'https://www.wikidata.org/wiki/Q7318217', 'display_name': 'Reverse cholesterol transport', 'level': 4, 'score': 0.52885044}, {'id': 'https://openalex.org/C2780541478', 'wikidata': 'https://www.wikidata.org/wiki/Q410020', 'display_name': 'High-density lipoprotein', 'level': 3, 'score': 0.47706735}, {'id': 'https://openalex.org/C2776448209', 'wikidata': 'https://www.wikidata.org/wiki/Q415555', 'display_name': 'Cholesteryl ester', 'level': 4, 'score': 0.4403548}, {'id': 'https://openalex.org/C2780072125', 'wikidata': 'https://www.wikidata.org/wiki/Q28350', 'display_name': 'Lipoprotein', 'level': 3, 'score': 0.4251157}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.40738592}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.26615775}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.17620417}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001510', 'descriptor_name': 'Bed Rest', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D053480', 'descriptor_name': 'Cholesterol Ester Transfer Proteins', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000273', 'descriptor_name': 'Adipose Tissue', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000273', 'descriptor_name': 'Adipose Tissue', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001823', 'descriptor_name': 'Body Composition', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053480', 'descriptor_name': 'Cholesterol Ester Transfer Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008076', 'descriptor_name': 'Cholesterol, HDL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008076', 'descriptor_name': 'Cholesterol, HDL', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D002149', 'descriptor_name': 'Energy Intake', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005247', 'descriptor_name': 'Feeding Behavior', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008019', 'descriptor_name': 'Life Style', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008055', 'descriptor_name': 'Lipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008055', 'descriptor_name': 'Lipids', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017524', 'descriptor_name': 'Slovenia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018667', 'descriptor_name': 'Tilt-Table Test', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055815', 'descriptor_name': 'Young Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/jc.2009-2561', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205775358', 'display_name': 'The Journal of Clinical Endocrinology & Metabolism', 'issn_l': '0021-972X', 'issn': ['0021-972X', '1945-7197'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20228163', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1210/jc.2009-2561', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S205775358', 'display_name': 'The Journal of Clinical Endocrinology & Metabolism', 'issn_l': '0021-972X', 'issn': ['0021-972X', '1945-7197'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W1508002143', 'https://openalex.org/W1965338173', 'https://openalex.org/W1970313703', 'https://openalex.org/W1977195981', 'https://openalex.org/W1980407235', 'https://openalex.org/W2001610389', 'https://openalex.org/W2006441443', 'https://openalex.org/W2023735255', 'https://openalex.org/W2030204904', 'https://openalex.org/W2035901431', 'https://openalex.org/W2041760854', 'https://openalex.org/W2048614243', 'https://openalex.org/W2083888364', 'https://openalex.org/W2108966129', 'https://openalex.org/W2111170630', 'https://openalex.org/W2124620553', 'https://openalex.org/W2141559778', 'https://openalex.org/W2147416676', 'https://openalex.org/W2153362477', 'https://openalex.org/W2154490896', 'https://openalex.org/W2166318177', 'https://openalex.org/W2166606079', 'https://openalex.org/W2166789921', 'https://openalex.org/W2175587614', 'https://openalex.org/W3141666803'], 'related_works': ['https://openalex.org/W4362127563', 'https://openalex.org/W2888082957', 'https://openalex.org/W2131740775', 'https://openalex.org/W2122454094', 'https://openalex.org/W2092737787', 'https://openalex.org/W2059653257', 'https://openalex.org/W2038635817', 'https://openalex.org/W1966227916', 'https://openalex.org/W1491900378', 'https://openalex.org/W123223230'], 'abstract_inverted_index': {'Context:': [0], 'Physical': [1, 237], 'inactivity': [2, 45, 238], 'is': [3, 19], 'associated': [4], 'with': [5, 217], 'insulin': [6, 106, 151], 'resistance': [7, 152], 'and': [8, 37, 56, 73, 97, 107, 109, 224], 'decreased': [9, 137, 167], 'high-density': [10], 'lipoprotein': [11, 193], '(HDL)': [12], 'cholesterol.': [13, 194], 'Cholesteryl': [14], 'ester': [15], 'transfer': [16, 28], 'protein': [17], '(CETP)': [18], 'involved': [20], 'in': [21, 52, 69, 86, 212, 219, 244], 'cholesterol': [22, 49, 169, 226], 'metabolism,': [23], 'being': [24], 'responsible': [25], 'for': [26], 'the': [27, 75, 94, 99, 102, 220], 'of': [29, 77, 80, 101, 150], 'cholesteryl': [30], 'esters': [31], 'from': [32], 'HDL': [33, 48, 168, 223, 240], 'to': [34], 'very': [35], 'low-': [36], 'low-density': [38, 192], 'lipoproteins.': [39], 'Objective:': [40], 'We': [41], 'hypothesized': [42], 'that': [43, 124], 'physical': [44], 'could': [46], 'decrease': [47], 'through': [50, 246], 'changes': [51, 211, 218], 'CETP': [53, 116, 196, 213, 247], 'availability.': [54], 'Design': [55], 'Participants:': [57], 'Twenty-four': [58], 'healthy,': [59], 'male': [60], 'volunteers': [61], '(aged': [62], '23.1': [63], '±': [64, 140, 160, 172, 181, 204], '0.5': [65], 'yr)': [66], 'were': [67, 89, 118], 'investigated': [68], 'eucaloric': [70], 'conditions': [71], 'before': [72], 'at': [74, 98, 242], 'end': [76, 100], '35': [78], 'd': [79], 'experimental': [81, 103], 'bed': [82, 126, 163, 200], 'rest.': [83, 164], 'Measures:': [84], 'Changes': [85], 'body': [87], 'composition': [88], 'monitored': [90], 'by': [91, 138, 158, 170, 179, 202], 'bioimpedance': [92], 'throughout': [93], 'study.': [95], 'Before': [96], 'period,': [104], 'plasma': [105, 110], 'glucose': [108], 'lipid': [111], 'pattern': [112], 'as': [113, 115], 'well': [114], 'concentrations': [117, 214], 'determined.': [119], 'Results:': [120], 'Our': [121], 'results': [122], 'demonstrated': [123], 'during': [125], 'rest,': [127], 'fat': [128], 'mass': [129, 136], 'did': [130, 188], 'not': [131, 189], 'change': [132, 190], 'significantly,': [133], 'whereas': [134, 186], 'fat-free': [135], '3.9': [139], '0.4%': [141], '(P': [142, 154, 174, 183, 206], '<': [143, 155, 175, 184, 207, 234], '0.01).': [144, 208], 'The': [145], 'homeostatic': [146], 'model': [147], 'assessment': [148], 'index': [149], 'significantly': [153, 191], '0.001)': [156], 'increased': [157, 177, 198], '47': [159], '11%': [161], 'after': [162, 199], 'Bed': [165, 209], 'rest': [166, 201], '12': [171], '3%': [173], '0.05),': [176, 185], 'triglycerides': [178], '51': [180], '10%': [182], 'it': [187], 'Plasma': [195], 'concentration': [197], '27': [203], '9%': [205], 'rest-induced': [210], 'inversely': [215], 'correlated': [216], 'ratio': [221], 'between': [222], 'non-HDL': [225], '(n': [227], '=': [228, 231], '24;': [229], 'R': [230], '−0.43;': [232], 'P': [233], '0.05).': [235], 'Conclusions:': [236], 'decreases': [239], 'cholesterol,': [241], 'least': [243], 'part,': [245], 'up-regulation.': [248]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2047835909', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-15T05:09:40.796045', 'created_date': '2016-06-24'}