Chronic Myocardial Hibernation in Humans

Name: Work Video:
Duration: 3 min 30 s
Jean‐Louis Vanoverschelde; William Wijns; Μ. Borgers; Guy R. Heyndrickx; Christophe Depré; Willem Flameng; Jacques Melin
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'prolonged': [401, 820, 842, 1089, 1597, 2877, 3152], '"ischemic"': [403], 'dysfunction': [404, 542, 861, 1117, 1390, 1542, 1561, 1617, 2090, 2792, 2819, 2833, 2852, 2879, 2886, 2963, 3231, 3646], 'did': [405, 2433], 'not': [406, 556, 1102, 1508, 1583, 1608, 2133, 2142, 2233, 2434, 2613, 2835, 2988, 3236, 3378, 3764], 'always': [407, 1829, 2845], 'arise': [408], 'from': [409, 731, 1768, 1820, 1835, 2216, 2365, 2670, 2798, 2889, 2975, 3389, 3698, 3779, 3901, 4002], 'tissue': [411, 500, 1105, 1677, 2180, 2198, 2467, 2500, 2523, 2544, 3487], 'and,': [413, 1973], 'some': [415, 599, 1268, 1340, 1975, 3167, 3347, 3948], 'extent,': [416, 1976], 'could': [417, 443, 1177, 1591, 2101, 2733, 2771, 2887, 3899, 3972], 'be': [418, 536, 585, 619, 808, 816, 895, 1178, 1335, 1565, 1830, 1883, 2121, 2546, 2618, 2734, 2772, 2928, 3245, 3268, 3752, 3938, 3973], 'reversed': [419], 'by': [420, 446, 481, 677, 711, 780, 1026, 1239, 1515, 1659, 1788, 2030, 2111, 2291, 2456, 2481, 2542, 2731, 2777, 2783, 2804, 2847, 2854, 2981, 3036, 3270, 3380, 3396, 3504, 3559, 3703, 3825, 3877, 3929, 3996, 4146], 'restoration': [421, 655, 1075], 'blood': [423, 752, 956, 1166, 1451, 1513, 1645, 2000, 2723, 2841, 3063, 3139], 'flow.2345': [424], 'These': [425, 991, 2811, 3292], 'observations': [426, 2782, 3050, 3163, 3519, 3543, 3873], 'have': [427, 639, 967, 993, 1198, 1215, 1375, 1395, 1728, 1935, 2016, 2148, 2787, 3564, 3609, 3614, 3950, 3984, 4013], 'led': [428], 'speculation': [431], 'chronically': [433, 2824, 3258, 3326], 'hypoperfused': [434], 'myocardium,': [435, 647, 1856, 2002, 2206, 3235, 3599, 4006], 'which': [436, 482, 1010, 1815, 2159, 3065, 3385, 3749], 'is': [437, 543, 596, 835, 855, 938, 1052, 1080, 1086, 1290, 1607, 1657, 1687, 1693, 1742, 1785, 1847, 1865, 1918, 1951, 2108, 2132, 2254, 2271, 2469, 2507, 2612, 2632, 2637, 2744, 2867, 2940, 3158, 3173, 3187, 3216, 3386, 3528, 3536, 3573, 3591, 3763, 3797, 4143], 'often': [438, 3034, 4106], 'referred': [439], 'as': [441, 458, 460, 477, 762, 778, 1024, 1141, 1529, 1531, 1710, 1811, 2201, 2524, 2548, 2602, 2656, 2949, 3199, 3449, 3460, 3502, 3600], '"hibernating,"23456': [442], 'maintain': [444], 'viability': [445], 'simply': [447], 'reducing': [448], 'its': [449, 487, 491, 745], 'metabolic': [450, 1271, 3658, 3787, 3811, 3835], 'demand': [451, 1333], 'match': [453], 'decreased': [455, 1311, 1331, 1688, 1758, 3035, 3081, 3141], 'supply': [456, 1003, 1167, 1329], 'for': [457, 520, 818, 1339, 1360, 1490, 1967, 2005, 2534, 2606, 2621, 2874, 3150, 3314, 3567, 3833, 3862], 'perfusion': [462, 804, 910, 1015, 1745, 1759, 1783, 1927, 2051, 2631, 2635, 2895, 2925, 3097, 3206], 'was': [463, 674, 708, 1237, 1424, 1502, 1507, 1562, 2328, 2343, 2360, 2407, 2424, 2690, 2834, 2844, 3033, 3338, 3350, 3362, 3377, 3399, 3424, 3446, 3510, 3556, 3624, 3685, 3935], 'inadequate.': [464], 'The': [465, 502, 591, 773, 1033, 1683, 1714, 1779, 1843, 1878, 3392, 3649, 4030, 4139], 'chronic': [466, 505, 526, 541, 547, 612, 686, 792, 857, 871, 1588, 1605, 1616, 1622, 2305, 2623, 2699, 2739, 2791, 2809, 2885, 2891, 2961, 2985, 3056, 3230, 3241, 3554, 3704, 3817], 'impairment': [467], 'contractile': [469, 933, 963, 1541, 2878, 2908, 2934, 2962, 3014, 3078, 3105, 3195, 3342, 4044, 4154], 'function': [470, 747, 755, 977, 1041, 1412, 1501, 1648, 2935, 3196], 'this': [472, 589, 594, 727, 812, 1043, 2252, 2550, 3086, 3349, 3706, 3794, 3917, 3976], 'setting': [473, 1044, 1673, 3745], 'regarded': [476, 2547], 'protective': [479], 'mechanism': [480, 2736, 2756, 2870], 'heart': [484, 743, 787, 838, 937, 1202], 'spontaneously': [485, 789], 'downgrades': [486, 744, 3009], 'function,': [489, 3501], 'minimizes': [490], 'energy': [492, 1022], 'requirements,': [493], 'prevents': [495], 'damage.245': [501], 'concept': [503, 3552], 'hibernation': [506, 614, 1289, 3243, 3555, 3585, 3898], 'thus': [507, 782, 1376, 1574, 2231, 2552, 3884], 'consists': [508], 'two': [510, 827, 1660, 3964, 3981, 3993], 'parts:': [511], 'unique': [513], 'clinical': [514, 631, 1672, 1699, 2280, 3921], 'observation': [515, 1151, 3129], 'bears': [517], 'important': [518, 2117], 'implications': [519], 'management': [522], 'patients': [524, 691, 915, 1636, 1656, 1945, 2026, 2035, 2154, 2259, 2278, 2313, 2336, 2366, 2399, 2415, 2443, 4003], 'disease23456': [529], 'pathophysiological': [532], 'hypothesis,': [533], 'yet': [534], 'demonstrated,': [537], 'implying': [538], 'due': [544], 'reduction': [548, 872, 1209, 1249, 1469, 1480, 1571, 1738, 2128, 2624, 3180, 3192], 'resting': [550, 874, 1211, 1653, 2023, 2316, 2339, 2402, 2417, 2594, 2610, 2630, 3194], 'MBF.45': [551], 'Other': [552], 'aspects': [553, 2118], 'were': [555, 1261, 2284, 2453, 3281, 3428, 3437, 3450, 3454, 3544, 3874, 4023], 'included': [557, 2149], 'original': [560], 'description,': [561], 'ie,': [562], 'rapidity': [564], 'mechanical': [566, 652, 2626], 'recovery': [567], 'after': [568, 704, 1059, 1413, 2065, 2820, 3031, 3082, 3142, 3647], 'successful': [569, 1219], 'revascularization7': [570], 'response': [573, 735, 868, 1409, 3011], 'dysfunctional': [575, 1762, 1904, 2043, 2063, 2688, 3259, 3327, 3930, 4000], 'myocardium': [576, 1639, 1692, 2029, 2107, 2262, 2653, 2795, 2939, 3623, 3696, 3934, 4022], 'inotropic': [578, 666, 1303], 'stimulation,': [579], 'are': [580, 756, 771, 1110, 1348, 1989, 2172, 2589, 3164, 3601, 3912, 4117, 4157], 'now': [581, 3592, 3708], 'also': [582, 2388, 2454, 3511, 3732, 3828, 3875], 'considered': [583, 3593], 'integral': [586], 'parts': [587], 'condition.': [590], 'purpose': [592], 'discussion': [595], 'review': [598], 'more': [602, 852, 3568, 3628], 'recent': [603], 'advances': [604], 'understanding': [607], 'pathophysiology': [610], 'humans.': [616], 'Emphasis': [617], 'will': [618, 1828], 'placed': [620], 'on': [621, 633, 648, 654, 661, 1217, 1695, 2176, 3286, 3299, 3657], 'perfusion-contraction': [623, 888, 1049, 1175, 1224, 1356, 1401, 1576, 1589, 1633], 'matching': [624, 889, 1176, 1225, 1357, 1590, 1634], 'both': [626, 980, 1231, 3271, 3318], 'experimental': [628, 1344, 1393, 3894], 'settings,': [632], 'peculiar': [635, 728, 4063], 'morphological': [636, 3264, 3652], 'changes': [637, 2916, 3133, 3265, 3334, 3603, 4018], 'shown': [641, 1199, 2905, 3936], 'occur': [643], 'hibernating': [646, 917, 1638, 1691, 1855, 2028, 2106, 2261, 2582, 2641, 2882, 2938, 3234, 3533, 3598, 3622, 3695, 3791, 3840, 4005, 4021, 4031, 4151], 'determinants': [650], 'reversibility': [653, 703, 3643], 'adequate': [657], 'patency,': [659], 'recruitable': [665], 'reserve.Perfusion-Contraction': [667], 'Matching': [668, 1626], 'HibernationThe': [671, 2958], 'term': [672], '"hibernation"': [673], 'first': [675, 834, 879, 3283], 'used': [676, 1990, 3639], 'Diamond': [678], 'et': [679, 1461, 1465, 1525, 1533, 2274, 2458, 2567, 2570, 2574, 2644, 2779, 3020, 3109, 3279, 3802, 3879], 'al6': [680], '1978': [682], 'describe': [684, 1992], 'wall': [687, 1826, 1841, 1863, 1891, 2317, 2340, 2370, 2403, 2418, 2448, 2701], 'motion': [688, 2371, 2419, 2449, 2702], 'abnormalities': [689, 2372], 'but': [696, 1384, 2052, 2843, 3931], 'no': [697, 1081, 2299, 2319, 2358, 2766, 3132, 3369, 3455], 'previous': [698, 2037, 2156, 2268, 2300], 'infarction': [700, 2039, 2270], 'their': [702, 1420, 2383, 3052, 3060, 4108], 'revascularization,': [705], 'subsequently': [709, 3610], 'popularized': [710], 'Rahimtoola45': [712], 'Braunwald': [714, 2748], 'Rutherford.2': [716], 'In': [717, 1419, 1493, 1552, 2192, 2312, 2335, 2398, 2414, 3059, 3346, 3793], 'his': [718], '1989': [719], 'description': [720], 'syndrome,': [723], 'Rahimtoola4': [724], 'postulated': [725, 3951], 'condition': [729], 'resulted': [730, 3697], '"relatively': [733], 'uncommon': [734], 'reduced': [737, 1327, 1511, 1825, 1909, 2050, 2072, 2114, 2839, 2997, 3013], 'MBF': [738, 973, 1654, 1666, 2024, 2322, 2342, 2480, 2948, 2993, 3007, 3025, 3135, 3182], 'at': [739, 1436, 1914, 3305, 3371, 4111], 'rest': [740, 1915], 'whereby': [741], 'extent': [750], 'flow': [753, 957, 1039, 1066, 1093, 1256, 1452, 1457, 1488, 1514, 1646, 1686, 1707, 1730, 1773, 1911, 1942, 2074, 2127, 2166, 2207, 2239, 2518, 2554, 2586, 2595, 2611, 2649, 2668, 2684, 2724, 2842, 3140], 'once': [757], 'again': [758], 'equilibrium,': [760], 'result,': [764], 'neither': [765], 'necrosis': [767, 1106, 1181, 1474], 'nor': [768], 'ischemic': [769, 860, 1389, 2137, 2741, 3475], 'symptoms': [770], 'present."': [772], 'definition': [774, 825], 'hibernation,': [777], 'formulated': [779], 'Rahimtoola,': [781], 'implies': [783], '(1)': [785, 4041], 'can': [788, 807, 815, 839, 894, 1203, 1334, 1358, 1882, 2545, 2616, 2796, 2872, 2927, 3244, 3267], 'adapt': [790, 840, 1205], 'underperfusion': [793, 845, 1606], '(the': [794], '"smart': [795], 'heart"': [796], 'hypothesis),': [797], '(2)': [798, 4046], 'new': [800, 813], 'steady': [801, 1324], 'state': [802, 1325, 2807, 2983], 'between': [803, 926, 971, 1001, 1326, 1456, 2213, 2330, 2409, 3579], 'reached,': [809], '(3)': [811, 4052], 'equilibrium': [814], 'maintained': [817, 1338], 'period': [821, 3153], 'time.': [823, 3155], 'This': [824, 1798, 2513], 'raises': [826], 'important,': [828], 'albeit': [829, 1115], 'conceptually': [830], 'different,': [831], 'questions:': [832], 'whether': [836, 856, 1173, 1902], 'periods': [843, 1062, 1090, 1544, 1598], 'while': [846], 'avoiding': [847], 'necrosis;': [848], 'second,': [850], 'clinically': [853], 'relevant,': [854], 'left': [858, 1387, 1483], 'ventricular': [859, 1388], 'humans': [863], 'represents': [864], 'such': [865, 1354, 1709, 2200, 2754, 3290, 3459, 3809], 'adaptive': [867], 'MBF.': [875, 1252], 'To': [876, 901, 2381], 'answer': [877, 902], 'question': [880, 905], 'necessitates': [881], 'development': [882, 1220, 1614], 'animal': [884], 'models': [885, 1399, 1988], 'sustained': [887, 1174, 1208, 1222, 1468, 2876, 3115, 3852], 'demonstration': [891], 'perpetuated': [896, 2806], 'over': [897, 1504, 1543, 1596], 'term.8': [900], 'second': [904], 'requires': [906, 1640, 2943], 'simultaneous': [907], 'assessment': [908, 1651], 'directly': [913, 1943], 'myocardium.Flow-Function': [918], 'Relations': [919], 'During': [920], 'Partial': [921], 'Coronary': [922, 2901], 'OcclusionThe': [923], 'tight': [924], 'coupling': [925, 1000], 'flow,': [928, 3064], 'oxygen': [930, 1328, 1332, 2392, 2405, 2422, 3521, 3724], 'consumption,': [931], 'performance': [934, 2909], 'fundamental': [940], 'principle': [941], 'cardiac': [943, 1077, 3966], 'physiology.': [944], 'Because': [945, 1744, 2533], 'small': [948, 3429], 'extraction': [949], 'reserve': [950, 2636, 2650, 2685], 'oxygen,': [952], 'decreases': [953, 961, 1158], 'rapidly': [958], 'translate': [959], 'into': [960, 2490], 'performance.1': [964], 'Several': [965, 1213, 2014], 'studies': [966, 992, 1581, 1700, 2033, 2057, 2131, 2147, 3298, 3911, 3983, 4012, 4148], 'examined': [968, 1406, 2813], 'relation': [970], '(radioactive': [974], 'microspheres)': [975], '(sonomicrometry)': [978], 'open-chest9': [981], 'conscious1011': [983], 'dogs': [984, 1536], 'undergoing': [985, 1189, 1477], 'graded': [986], 'reductions': [987, 2720], 'flow.': [990, 2680], 'demonstrated': [994, 2773, 3269], 'existence': [996], 'close': [999], 'substrates,': [1006], 'including': [1007, 1263, 4040], 'O2,': [1008], 'measurement': [1012], 'provides': [1016, 1747, 2515], 'rough': [1018, 4049], 'estimate,12': [1019], 'demand,': [1023], 'reflected': [1025, 3503], 'steady-state': [1028], 'level': [1029, 1161, 2021, 2125, 2237], 'contraction.': [1032], 'proportional': [1034], 'decrease': [1035, 1427, 1498, 2677, 2892, 2922], 'called': [1047, 1121, 1227], '"acute': [1048], 'matching"': [1050], 'typical': [1053, 3407], 'acute': [1055, 1154, 2851, 3474], 'ischemia.': [1057], 'Reperfusion': [1058], 'very': [1060, 2217, 3048, 3363], 'short': [1061], 'low': [1064, 1255, 2218], '(<10': [1067], 'minutes)': [1068], 'usually': [1069, 1103, 1131, 1719, 3496], 'rapid': [1072, 3864], 'complete': [1074, 2304], 'performance.': [1078], 'There': [1079, 3453], 'necrosis,': [1082], 'ultrastructure': [1085], 'normal.': [1087], 'More': [1088, 1518], 'reduction,': [1094], 'up': [1095, 1397, 3069, 3626], '15': [1097], '20': [1099], 'minutes,': [1100], 'do': [1101, 1582], 'cause': [1104], 'but,': [1107], 'reperfusion,': [1109], 'associated': [1111, 1509, 2836], 'prolonged,': [1114], 'reversible,': [1116], 'stunning.13': [1123], 'Further': [1124, 3910], 'increases': [1125, 2856], 'duration': [1128], 'result': [1132, 1765, 1868, 2797, 2888, 3755, 3900], 'variable': [1134, 2151], 'degrees': [1135], 'damage.14Myocardial': [1139], 'Adaptive': [1143], 'Response': [1144], 'Sustained': [1146], 'Reduction': [1147, 2946], 'Resting': [1149], 'MBFThe': [1150], 'under': [1153, 1342, 1366, 3184, 3618], 'conditions': [1155, 3186], 'matched': [1162], 'available': [1165, 1350], 'inclined': [1169], 'investigators': [1170, 1214, 1373, 2015, 3613, 3949], 'examine': [1172], 'achieved': [1179, 1336, 1467], 'without': [1180, 1473, 2369, 2446], 'being': [1182], 'induced.': [1183], 'Studies': [1184], 'open-chest': [1186], 'anesthetized': [1187], 'animals': [1188, 1365, 1595], '1': [1190], '5': [1192], 'hours': [1193, 3030], 'partial': [1195, 1844, 1978], 'occlusion': [1197, 1242, 1441, 2306, 3075], 'indeed': [1204, 2109, 2173, 2485, 3615, 4033], 'MBF.151617181920': [1212], 'reported': [1216, 2455, 3547, 3616, 3876, 4135], 'low-flow': [1223], '(also': [1226], 'short-term': [1228, 3123], 'hibernation)': [1229], 'dog15': [1232], 'pig': [1234, 3120], 'heart.1617181920': [1235], 'Ischemia': [1236], 'produced': [1238, 4009], 'incomplete': [1240], 'leading': [1243, 2737], '20%': [1246, 1871, 2676, 3037], '70%': [1248], 'transmural': [1251, 2211, 2667, 3138], 'Despite': [1253], 'continuing': [1254], 'dysfunction,': [1258, 3079], 'intriguing': [1259, 3128, 3671], 'phenomena': [1260], 'observed,': [1262], 'spontaneous': [1265], 'resolution': [1266, 1792, 1962], 'markers': [1272], '(mainly': [1275], 'lactate': [1276, 1309], 'production)1516': [1277], 'regeneration': [1280], 'PCr': [1282, 3495], 'back': [1283, 2757], 'nearly': [1285, 2633, 3498, 3512, 3717], 'normal': [1286, 1729, 1840, 2068, 2224, 2315, 2331, 2401, 2599, 3068, 3632, 3715, 3718], 'levels.17181920': [1287], 'Short-term': [1288], 'fragile': [1292], 'unstable': [1294], 'condition,': [1295], 'because': [1297, 1857, 2761, 3924], 'superimposition': [1298], 'chronotropic': [1301], 'or': [1302, 1362, 1712, 1921, 2069, 2716, 3226, 3368, 3468, 3477, 3716, 3958], 'stress': [1304, 3146], 'invariably': [1305], 'increased': [1308, 3662, 3690], 'production,': [1310], 'PCr,': [1312], 'necrosis.1920Although': [1316], 'above': [1318, 1580, 2146, 3162], 'findings': [1319, 2452, 3656], 'suggest': [1320, 1603, 2863, 3885], 'precarious': [1323], 'time': [1341, 1438, 1505, 2815, 3072, 3307], 'particular': [1343], 'conditions,': [1345, 3620], 'few': [1346, 3367], 'data': [1347, 2862, 3653, 3883], 'presently': [1349], 'indicate': [1352, 3473], 'persist': [1359], 'weeks': [1361], 'months': [1363], 'long-term': [1367, 1381, 2931], 'study.': [1368], 'On': [1369], 'contrary,': [1371], 'most': [1372, 2130, 2972], 'who': [1374], 'far': [1377, 4132], 'succeeded': [1378, 1537], 'reproducing': [1380], '(>1': [1382], 'week)': [1383], 'reversible': [1385], 'laboratory': [1394], 'ended': [1396], 'mismatch.': [1402, 1577], 'Canty': [1403, 3044], 'Klocke21': [1405, 3046], 'temporal': [1408], 'ameroid': [1414, 1433, 1440, 2821, 3057, 3074, 3083], 'implantation': [1415, 2822], 'conscious': [1417], 'dogs.': [1418], 'model,': [1421], 'found': [1425, 1563, 2060, 2329, 2361, 2576, 2661, 2828], 'during': [1429, 3136, 3870], 'course': [1431, 2816], 'occlusion.': [1434, 3058, 3084], 'Yet,': [1435], '(2': [1442], '4': [1444, 3027], 'weeks),': [1445], 'measurements': [1447], 'endocardial': [1450], 'showed': [1453, 3440, 3846], 'dissociation': [1455], 'function.': [1459, 3015, 3106], 'Bolukoglu': [1460, 3878], 'al22': [1462], 'Liedtke': [1464, 3801], 'al23': [1466, 3803], 'segmental': [1471, 1500], 'shortening': [1472], 'swine': [1476], '50%': [1479], 'anterior': [1484], 'descending': [1485], 'velocity': [1489], '7': [1491], 'days.': [1492], 'these': [1494, 1555, 1717, 1895, 2098, 2705, 2861, 3185, 3541, 3580, 3728, 3882, 3992], 'experiments': [1495], 'too,': [1496], 'progressive': [1503, 3093, 3179], 'subendocardial': [1512, 2840, 3062], 'day': [1516], '4.': [1517], 'recently,': [1519], 'Shen': [1520, 2784], 'Vatner24': [1522, 2786], 'Fallavollita': [1524], 'al25': [1526], 'pigs': [1528, 2826, 3815], 'well': [1530, 3425, 3529], 'Gerber': [1532], 'al26': [1534], 'producing': [1539], '1,': [1546], '3,': [1547], '6': [1549, 3029], 'months,': [1550], 'respectively.': [1551], 'each': [1553], 'studies,': [1556, 2099], 'severity': [1558, 2697], 'out': [1566], 'proportion': [1568, 2152], 'MBF,': [1573], 'demonstrating': [1575], 'Although': [1578, 2760, 3156, 3683], 'dismiss': [1584], 'possibility': [1586, 2991], 'exist': [1592], 'intact': [1594], 'time,': [1600], 'they': [1601, 3563, 4008, 4116], 'nevertheless': [1602], 'necessary': [1610], 'prerequisite': [1611], 'stenoses.Perfusion-Contraction': [1625], 'Patients': [1628], 'Hibernating': [1630, 3213], 'MyocardiumAssessment': [1631], 'ability': [1642, 1939], 'measure': [1644, 1941, 2476, 3987], 'simultaneously.8': [1649], 'Direct': [1650], 'complicated': [1658], 'factors:': [1661], 'difficulty': [1663], 'measuring': [1665], 'absolute': [1668, 1770, 3721], 'terms': [1669], 'heterogeneity': [1678, 2468], 'ischemically': [1680], 'injured': [1681], 'myocardium.': [1682, 2334, 2883, 3043, 3792, 3841], 'contention': [1684], 'human': [1690, 3300], 'based': [1694], 'relative': [1703, 1751, 1782], 'distribution': [1704, 4064], 'radiolabeled': [1706, 1910], 'tracers': [1708], '201Tl,27282982Rb,30': [1711], '99mTc-MIBI.31': [1713], 'interpretation': [1715, 2163], 'scintigrams': [1718], 'assumes': [1720], 'segments': [1723, 2044, 2064, 2087, 2350, 2364, 2441, 2583, 2689, 3261, 4001], 'maximum': [1725], 'tracer': [1726, 1740, 1754, 1912, 2185], 'uptake': [1727, 1741, 1913, 3692, 3926], 'any': [1733, 2265, 2535], 'region': [1734, 1823, 1837, 2189, 2503, 2530], 'apparent': [1737], 'underperfused.': [1743], 'scintigraphy': [1746, 1784], 'only': [1748, 2070, 3366, 3574, 3980], 'estimates': [1749, 2009, 2169, 2208], 'differences': [1752], 'distribution,': [1755], 'seemingly': [1757], 'segment': [1763, 1906], 'may': [1764, 2232, 2994], 'part': [1767, 2244, 2559], 'increase': [1771, 2673, 3094, 3203], 'remote': [1776, 2346, 2410, 2427, 3631], 'hyperfunctioning': [1777], 'tissue.32': [1778], 'accuracy': [1780], 'further': [1786, 2944, 4144], 'affected': [1787, 3000], 'limited': [1790, 3351], 'spatial': [1791, 1961, 2197], 'current': [1795], 'SPECT': [1796, 1917], 'devices.': [1797], 'significant': [1801, 1890], 'underestimation': [1802, 1874, 1881], 'true': [1804], 'activity': [1806, 3957], 'concentrations,': [1807], 'phenomenon': [1809], '"partial': [1812], 'volume': [1813, 1845, 1979, 3383], 'effect,"': [1814], 'describes': [1816], 'how': [1817], 'counts': [1818], 'measured': [1819, 1834, 2323, 2597, 3026, 3726], 'thickness': [1827], 'lower': [1831, 2093], 'than': [1832, 1963, 2347, 2428, 3569, 3630], 'those': [1833, 2288, 4092], 'thickness.33': [1842], 'effect': [1846], 'particularly': [1848, 1930], 'relevant': [1849], 'situation': [1852], 'sole': [1859], 'loss': [1860, 3340, 3376, 4068], 'systolic': [1862], 'thickening': [1864], 'expected': [1866, 3753], '25%': [1873, 3039], 'counts.34': [1877], 'degree': [1879], 'even': [1884, 2092, 2911], 'larger': [1885], 'thinning.': [1892], 'Taken': [1893], 'together,': [1894], 'limitations': [1896], 'make': [1897], 'difficult': [1899], 'determine': [1901], 'exhibits': [1908], 'truly': [1919, 1953], 'underperfused': [1920], 'not.': [1922], 'Recent': [1923], 'refinements': [1924], 'imaging,': [1928], 'PET,': [1934], 'greatly': [1936, 2160], 'enhanced': [1937], 'our': [1938], 'disease.353637': [1949], 'PET': [1950, 2171, 2327, 2474], 'quantitative': [1954, 2008, 2056, 3997], 'method.': [1955], 'It': [1956, 2432, 2743, 3535, 3572, 3730], 'much': [1959], 'better': [1960], 'SPECT;': [1964], 'allows': [1966, 2004, 2486], 'accurate': [1968], 'correction': [1969], 'photon': [1971], 'attenuation': [1972], 'effects;': [1980], 'finally,': [1982], 'when': [1983], 'mathematically': [1984], 'physiologically': [1986], 'appropriate': [1987], 'biological': [1994], 'behavior': [1995], 'radiotracers': [1998], 'computation': [2006], 'perfusion.': [2013, 2115], 'attempted': [2017, 3985], 'assess': [2019], 'PET.': [2031, 2397], 'Initial': [2032], 'indicated': [2040, 3023], 'reversibly': [2042, 2062], 'corresponded': [2045], 'areas': [2047, 2080, 2221], 'qualitatively': [2049], 'preserved': [2053, 3530], 'metabolism.383940': [2054], 'However,': [2055], 'using': [2058, 2394, 2654], '[13N]ammonia': [2059, 2325], 'revascularization': [2066], 'had': [2067, 2091, 2294, 2751, 3066], 'mildly': [2071, 2113], 'baseline': [2073, 2585], 'compared': [2075], 'remote,': [2077], 'normally': [2078], 'contracting': [2079], 'same': [2083], 'patients,': [2084], 'persistent': [2089], 'values.4142On': [2094], 'basis': [2096], 'one': [2100, 3224], 'inadvertently': [2102], 'conclude': [2103], 'characterized': [2110], 'Two': [2116], 'must': [2119], 'nonetheless': [2120, 3913], 'considered.': [2122], 'First,': [2123], 'sufficient': [2134], 'justify': [2136], 'dysfunction.8': [2138], 'Second,': [2139], 'if': [2141, 2629, 3760], 'all': [2143, 3237, 4085], 'infarction,': [2158, 2302], 'complicates': [2161], 'data.': [2167], 'Flow': [2168], 'critically': [2174], 'dependent': [2175, 2440], 'mass': [2178], 'actively': [2182], 'participates': [2183], 'exchange': [2186, 2539], 'within': [2187, 2590], 'interest.': [2191, 2532], 'marked': [2196], 'heterogeneity,': [2199], 'occurs': [2202], 'previously': [2204, 3394], 'infarcted': [2205], 'represent': [2209], 'average': [2212], 'several': [2214, 3548], 'values': [2215, 2516, 2587, 2596], 'microinfarcted': [2220], 'almost': [2223], 'noninfarcted': [2227], 'epicardial': [2228], 'zones': [2229], 'reflect': [2234], 'actual': [2236], 'seen': [2240, 3183, 3335, 3837, 3892, 4128], 'viable': [2243], 'wall.': [2247, 2562], 'One': [2248, 3329], 'approach': [2249, 2461, 2514], 'circumvent': [2251, 2463], 'problem': [2253], 'study': [2256, 2764, 2776], 'carefully': [2257], 'selected': [2258], 'whom': [2264], 'lacking.': [2272], 'al32': [2275, 2645], 'studied': [2276, 3111], '26': [2277], 'whose': [2279], 'angiographic': [2282], 'characteristics': [2283, 4087], 'quite': [2285, 3740], 'similar': [2286, 3049], 'initially': [2289], 'described': [2290], 'Rahimtoola.4': [2292], 'All': [2293], 'symptomatic': [2295], 'disease,': [2298], 'major': [2309, 3381, 3965], 'artery.': [2311], 'motion,': [2318, 2341, 2404], 'difference': [2320, 2359], 'collateral-dependent': [2333, 2349, 2363, 2430, 2652, 2794], 'higher': [2344, 2425], '(95±27': [2351], 'versus': [2352, 2374], '77±25': [2353], 'mL·min−1·100': [2354, 2376], 'g−1,': [2355, 2377], 'P<.001).': [2356], 'Yet': [2357], 'among': [2362, 2438], '(77±25': [2373], '85±14': [2375], 'P=NS)': [2378], '(Fig': [2379, 3344], '1).': [2380], 'corroborate': [2382], 'surprising': [2384], 'results,': [2385], 'authors': [2387, 2706, 2812, 3293], 'investigated': [2389, 2646], 'consumption': [2393, 2406, 2423, 3522], '[11C]acetate': [2395, 3525], 'comparable': [2408], 'collateralized': [2412], 'segments.': [2413, 2431, 2642, 3001, 3729], 'abnormalities,': [2420], 'differ': [2435], 'significantly,': [2436], 'collateral': [2439, 2683], 'abnormalities.': [2450, 2703, 3291], 'Similar': [2451, 3872], 'Sambuceti': [2457], 'al.43': [2459], 'Another': [2460], 'problems': [2465], 'use': [2471, 2482], '[15O]H2O': [2472, 2484], 'MBF.4445': [2477], 'Quantification': [2478], 'us': [2487], 'incorporate': [2489], 'kinetic': [2492], 'model': [2493, 3054, 3121], 'estimate': [2495], 'fraction': [2498], 'interest': [2505], 'exchanging': [2508], 'freely': [2510], 'diffusible': [2511], 'water.4445': [2512], 'per': [2519, 2527], 'gram': [2520, 2528], 'perfusable': [2522], 'opposed': [2525], 'practical': [2536], 'purposes,': [2537], 'water': [2541], 'scar': [2543], 'negligible,': [2549], 'technique': [2551], 'measures': [2553], 'predominantly': [2555], 'nonnecrotic': [2558], 'Using': [2563], '[15O]H2O,': [2564], 'de': [2565], 'Silva': [2566], 'al,46': [2568], 'Marinho': [2569], 'al,47': [2571], 'Conversano': [2573], 'al48': [2575], '80%': [2578], '90%': [2580], 'exhibited': [2584], 'range': [2592, 2664], 'regions.Repeated': [2600], 'Stunning': [2601], 'Plausible': [2604], 'Mechanism': [2605], 'Chronic': [2607, 2957, 3820], 'HibernationIf': [2609], 'reduced,': [2614], 'what': [2615], 'then': [2617], 'trigger': [2620], 'function?': [2627], 'Even': [2628, 3759], 'normal,': [2634], 'highly': [2638], 'dipyridamole': [2655], 'hyperemic': [2658, 2666], 'agent.': [2659], 'They': [2660, 3125], 'wide': [2663], 'values,': [2669], 'fourfold': [2672], 'basal': [2679], 'Importantly,': [2681], 'markedly': [2691], 'blunted': [2692], 'correlated': [2694], 'suggested': [2707, 3687, 4014], 'repetitive': [2709, 2865], 'intermittent': [2710], 'episodes': [2711, 2800, 2849, 2977], '(either': [2714], 'exercise-induced': [2715], 'related': [2717, 3165], 'primary': [2719], '[plaque': [2725], 'events,': [2726], 'vasoconstriction,': [2727], 'platelet': [2728], 'aggregation])': [2729], 'followed': [2730, 2803, 2980], 'stunning': [2732, 2770, 2866, 2986, 3221], 'dysfunction.': [2742], 'worth': [2745, 3798], 'mentioning': [2746, 3799], 'Kloner49': [2750], 'already': [2752, 3022], 'proposed': [2753, 3830], '1982.': [2759], 'design,': [2765], 'single': [2767], 'episode': [2768], 'al,32': [2780], 'subsequent': [2781, 3518], 'provided': [2788, 3312], 'repeated': [2799, 2848, 2976], 'stunning.': [2810, 3248], 'instrumented': [2825], 'onset': [2831], 'permanently': [2838], 'preceded': [2846], 'induced': [2853, 3850], 'transient': [2855, 3848], 'demand.': [2859], 'Altogether,': [2860], 'plausible': [2869], 'account': [2873, 3832], 'Alternatively,': [2884], 'pressure': [2896, 2902, 2926, 3098], 'poststenotic': [2899], 'bed.5051': [2900], 'regulate': [2907], 'acutely,': [2910], 'absence': [2914], 'flow.52': [2919], 'Whether': [2920], 'involved': [2929, 3974], 'regulation': [2932], 'unknown': [2941], 'investigation.Chronic': [2945], 'Consequence': [2951], 'Rather': [2952], 'Than': [2953], 'Cause': [2955], 'fact': [2959], 'severe': [2968], 'likely': [2973], 'does': [2987], 'exclude': [2989], 'become': [2996], 'Indeed,': [3002], 'increasing': [3003], 'suggests': [3005], 'Back': [3016], '1975,': [3018], 'al13': [3021], 'reperfusion': [3032], 'acutely': [3041], 'stunned': [3042], 'made': [3047, 3126, 3545], 'dog': [3053], 'experiments,': [3061], 'remained': [3067, 3148, 3497], 'peak': [3077], 'gradually': [3080], 'Interestingly,': [3085], 'occurred': [3087, 3813], 'face': [3090], 'slow': [3101], 'normalization': [3102], 'Recently,': [3107], 'Berman': [3108], 'al53': [3110], 'effects': [3113], 'demand-induced': [3116], 'hibernation.': [3124], 'that,': [3130], 'despite': [3131], 'stress,': [3137], 'depressed': [3149], 'possible': [3159, 3768], 'form': [3168, 3857], 'microvascular': [3170], 'stunning,': [3171], 'tempting': [3174], 'hypothesize': [3176], 'somehow': [3188], 'secondary': [3189], 'serves': [3198], 'means': [3201], 'residual': [3204], 'reserve.54Structural': [3207], 'Metabolic': [3209], 'Alterations': [3210], 'MyocardiumAlthough': [3214], 'there': [3215], 'little': [3217], 'doubt': [3218], 'contributes': [3222, 3784], 'way': [3225], 'another': [3227], 'features': [3239, 4036], 'ascribed': [3246], 'Since': [3249], 'early': [3251], '1980s,': [3252], 'exhibit': [3262], 'distinct': [3263], 'light': [3273], 'electron': [3276, 3412], 'microscope.': [3277], 'al5556': [3280], 'report': [3285], 'conducted': [3294], 'series': [3296], 'biopsy': [3302], 'samples': [3303], 'harvested': [3304], 'bypass': [3309], 'surgery': [3310], 'specific': [3315, 4158], 'alterations': [3316, 3582, 3788, 3836, 3888], 'affecting': [3317], 'cardiomyocytes': [3320, 3337, 4032, 4090, 4131, 4152], 'extracellular': [3323], 'matrix': [3324], 'segments.325556575859': [3328], 'striking': [3330], 'feature': [3331, 3635], 'material': [3343, 3406], '2).58': [3345], 'cells,': [3348, 4095], 'vicinity': [3354], 'nucleus,': [3357], 'whereas': [3358, 4115], 'others': [3360], 'extended,': [3364], 'leaving': [3365], 'sarcomeres': [3370, 3423, 4101], 'periphery.': [3374], 'Myofibrillar': [3375], 'accompanied': [3379], 'changes,': [3384], 'clearly': [3387], 'different': [3388], 'atrophic': [3390], 'degeneration.': [3391], 'space': [3393], 'occupied': [3395], 'myofilaments': [3398], 'filled': [3400], 'amorphous,': [3403], 'strongly': [3404], 'PAS-positive': [3405], 'glycogen.': [3409], 'Under': [3410], 'microscope,': [3413], 'general': [3415], 'organization': [3416], 'pattern': [3417, 3774], 'remaining': [3420, 4100], 'peripherally': [3421], 'located': [3422], 'preserved.': [3426], 'Mitochondria': [3427], 'scattered': [3431], 'throughout': [3432], 'myolytic': [3434], 'cytoplasm.': [3435], 'Nuclei': [3436], 'tortuous': [3438], 'uniformly': [3441], 'dispersed': [3442], 'heterochromatin.': [3443], 'Sarcoplasmic': [3444], 'reticulum': [3445], 'virtually': [3447], 'absent,': [3448], 'T': [3451, 4076], 'tubules.': [3452], 'signs': [3456], 'degeneration,': [3458], 'cytoplasmic': [3461], 'vacuolization,': [3462], 'edema,': [3463], 'mitochondrial': [3464], 'swelling,': [3465], 'membrane': [3466], 'disruption,': [3467], 'lipid': [3469], 'droplets,': [3470], 'would': [3472, 3731, 3750], 'cellular': [3478], 'atrophy.': [3479], 'From': [3480], 'biochemical': [3482, 3675], 'point': [3483], 'view,': [3485], 'content': [3488], 'ATP,': [3490], 'adenine': [3492], 'nucleotides,': [3493], 'normal.57': [3499], 'Mitochondrial': [3500], 'ADP/ATP': [3506], 'PCr/ATP': [3508], 'ratios,': [3509], 'intact,57': [3513], 'finding': [3515, 3742], 'consistent': [3516], '(measured': [3523], 'PET)': [3527], 'myocardium.3260': [3534], 'interesting': [3537], 'note': [3539], 'critical': [3542], 'years': [3549], 'before': [3550], 'put': [3557], 'forward': [3558], 'Rahimtoola': [3560], 'ignored': [3566], 'decade.': [3571], 'recently': [3575, 3804, 3845], 'link': [3578], 'structural': [3581, 4017], 'established.3258': [3588], 'Their': [3589], 'hallmark': [3595], 'glucose': [3606, 3627, 3679, 3691, 3783, 3890, 3928, 3967, 3994], 'utilization': [3607, 3778], 'described.Several': [3612], 'fasting': [3619], 'taking': [3625], 'avidly': [3629], 'myocardium,406162': [3633], 'predict': [3641], 'revascularization.40': [3648], 'comparison': [3650], 'imaging': [3659], '(which': [3660], 'demonstrates': [3661], 'rate': [3663], 'FDG': [3665], 'transport': [3666], 'phosphorylation)': [3668], 'raised': [3670], 'questions': [3672], 'about': [3673], 'fate': [3676], 'exogenous': [3678], '"hibernating"': [3681], 'cells.63': [3682], 'originally': [3686], 'stimulation': [3699], 'anaerobic': [3701], 'metabolism': [3702, 3891], 'ischemia,64': [3705], 'explanation': [3707], 'appears': [3709], 'unlikely': [3710], 'view': [3712], 'levels': [3719], 'MBF32414243464748': [3722], 'consumption3260': [3725], 'hardly': [3733], 'explain': [3734], 'accumulation': [3736, 4053], 'glycogen,': [3738, 4055], 'unusual': [3741], 'ongoing': [3747, 3761], 'ischemia,': [3748], 'rather': [3751], 'opposite.65': [3758], 'implicated,': [3765], 'remains': [3767], 'change': [3771, 3954], 'substrate': [3777], 'fatty': [3780], 'acid': [3781], 'regard,': [3795], 'presented': [3805], 'strong': [3806], 'switch': [3812], 'stenosis.': [3819], 'activation': [3821, 3853], 'glycogen': [3823, 3859, 3868, 3908, 4127], 'synthase': [3824], 'McNulty': [3842], 'Luba66': [3844], 'glucose-6-phosphate–independent': [3856], 'synthase,': [3860], 'allowing': [3861], 'replenishment': [3865], 'stores': [3869], 'reperfusion.': [3871], 'al.67': [3880], 'Together,': [3881], 'concerted': [3903], 'deregulation': [3904], 'glycolysis': [3906], 'synthesis.': [3909], 'required': [3914], 'verify': [3916], 'hypothesis': [3918, 4140], 'setting.': [3922], 'Finally,': [3923], 'metabolically': [3932], 'active': [3933], 'relatively': [3939], 'independent': [3940], 'hormonal': [3943], 'milieu': [3944], 'dietary': [3946], 'conditions,6162': [3947], 'expression': [3961], 'transporters,': [3968], 'GLUT-1': [3969], 'GLUT-4,': [3971], 'phenomenon.68': [3977], 'So': [3978], 'far,': [3979], 'preliminary': [3982], 'messenger': [3989], 'RNA': [3990], 'transporters': [3995], 'PCR': [3998], 'conflicting': [4010], 'results.6869Recent': [4011], 'occurring': [4019], 'consequence': [4025], 'dedifferentiation': [4028, 4142], 'process.': [4029], 'show': [4034], 'neonatal': [4038], 'cardiomyocytes,70': [4039], 'depletion': [4042], 'filaments,': [4045], 'sarcoplasmic': [4050, 4071], 'reticulum,': [4051, 4072], '(4)': [4056], 'occurrence': [4057], 'irregularly': [4059], 'shaped': [4060], 'nuclei': [4061], 'chromatin,': [4066], '(5)': [4067], 'organized': [4070], '(6)': [4073], 'lack': [4074], 'tubules,': [4077], '(7)': [4079], 'vesiculization': [4080], 'sarcolemma.58': [4083], 'Not': [4084], 'altered': [4089, 4104, 4130], 'resemble': [4091], 'embryonic': [4094, 4121], 'however.': [4096], 'For': [4097], 'instance,': [4098], 'cells': [4105], 'retain': [4107], 'orderly': [4109], 'arrangement': [4110], 'periphery,': [4114], 'randomly': [4118], 'distributed': [4119], 'cells.': [4122], 'Also,': [4123], 'amount': [4125], 'exceeds': [4133], 'embryo.': [4138], 'substantiated': [4145], 'immunohistological': [4147], 'showing': [4149], 'reexpress': [4153], 'proteins': [4155], 'feta': [4161]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2046550786', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-10T03:41:41.137035', 'created_date': '2016-06-24'}
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