Mitofusin-2 Is a Major Determinant of Oxidative Stress-mediated Heart Muscle Cell Apoptosis

Name: Work Video:
Duration: 3 min 30 s
Tao Shen; Ming Zheng; Chunmei Cao; Chunlei Chen; Jian Tang; Wanrui Zhang; Heping Cheng; Kuang‐Hueih Chen; Rui‐Ping Xiao
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3117, 3166, 3223, 3251, 3342, 3400, 3473, 3492, 3497, 3505, 3639, 3683, 3807, 3811, 3881, 3894, 3907, 3926, 4000, 4015, 4082, 4089, 4106, 4141, 4171, 4189, 4210, 4219, 4250, 4268, 4291, 4300], 'terminally': [4, 204], 'differentiated': [5, 205], 'heart': [6, 15, 158, 178, 198, 206, 215, 358, 378, 398, 658, 1458, 1518, 1548, 1568, 2728, 2740, 2893, 3094, 3124, 3435, 4203], 'muscle': [7, 113, 159, 179, 207, 313, 359, 379, 918, 1519, 1549, 1663, 3095, 3125, 3294, 3350, 3436, 3836, 3940, 4204], 'cells': [8, 208, 919, 1385, 1390, 1520, 2114, 2175, 2200, 2243, 2422, 2538, 2575, 2995, 3021, 3183, 3217, 3259, 3361, 3409, 3560, 3566, 3622, 3664, 3837, 3941, 4127, 4162, 4251, 4323], 'is': [9, 41, 89, 170, 209, 241, 289, 370, 1291, 1453, 1499, 1540, 1873, 2724, 2877, 3002, 3079, 3098, 3120, 3308, 3333, 3357, 3430, 3450, 3459, 3921, 4009, 4230], 'a': [10, 35, 42, 74, 111, 188, 193, 210, 235, 242, 274, 311, 388, 393, 437, 464, 522, 597, 609, 689, 993, 1131, 1141, 1188, 1280, 1558, 1563, 1621, 1801, 2225, 2231, 2274, 2281, 2492, 2562, 2593, 2602, 2695, 2846, 2878, 2967, 2979, 3015, 3044, 3133, 3174, 3188, 3321, 3347, 3387, 3629, 3684, 4109, 4142, 4167, 4172, 4197], 'crucial': [11, 189, 211, 389, 1559, 3630], 'causal': [12, 212, 615], 'factor': [13, 213], 'for': [14, 175, 197, 214, 375, 397, 467, 651, 1351, 1545, 1567, 1821, 1830, 1835, 1841, 2186, 2260, 2317, 2324, 2411, 2423, 2662, 2971, 3274, 3335, 3432, 3453, 3573, 3576, 3594, 4201, 4262], 'failure.': [16, 199, 216, 399, 1569], 'Here,': [17, 217, 1502], 'we': [18, 218, 898, 1503, 2830, 3129, 3327, 3550, 3585, 3876, 3976, 3995, 4236], 'have': [19, 219, 686, 742, 986, 3821], 'provided': [20, 220], 'several': [21, 221, 3297], 'lines': [22, 222, 913, 3300, 3841], 'evidence': [24, 224, 640, 1129, 2685], 'to': [25, 56, 73, 77, 84, 225, 256, 273, 277, 284, 751, 940, 980, 1270, 1405, 1438, 1505, 1527, 1769, 1875, 1883, 1900, 2203, 2420, 2500, 2545, 2736, 2845, 2941, 2966, 3109, 3122, 3132, 3146, 3264, 3310, 3329, 3539, 3565, 3597, 3826, 3924, 4233, 4271, 4319], 'demonstrate': [26, 226], 'that': [27, 78, 141, 165, 183, 227, 278, 341, 365, 383, 744, 901, 935, 988, 1118, 1272, 1294, 1345, 1392, 1535, 1553, 2688, 2719, 3004, 3076, 3092, 3147, 3375, 3427, 3552, 3626, 3794, 3823, 3980, 4099, 4187], 'mitofusin-2': [28, 228, 694], '(Mfn-2;': [29, 229], 'also': [30, 230, 696, 1292, 3061, 4123], 'called': [31, 231], 'hyperplasia': [32, 232, 698], 'suppressor': [33, 233, 699], 'gene),': [34, 234], 'member': [36, 236, 995], 'the': [38, 149, 238, 349, 441, 636, 647, 752, 929, 997, 1055, 1285, 1299, 1457, 1515, 1529, 1588, 1641, 1701, 1785, 1852, 1862, 1866, 1870, 1877, 1884, 1891, 1962, 2187, 2196, 2421, 2427, 2546, 2571, 2588, 2597, 2634, 2647, 2737, 2817, 2825, 2927, 2983, 3139, 3249, 3381, 3451, 3466, 3481, 3485, 3490, 3495, 3503, 3541, 3600, 3617, 3801, 3878, 3884, 3978, 3997, 4003, 4013, 4160, 4190, 4208, 4295, 4313], 'mitofusin': [39, 239], 'family,': [40, 240, 1301], 'major': [43, 243, 2696, 2879], 'determinant': [44, 244], 'oxidative': [46, 51, 105, 176, 246, 251, 305, 376, 1288, 1546, 2692, 2834, 2849, 3087, 3150, 3336, 3433, 4212], 'stress-mediated': [47, 247, 2835], 'cardiomyocyte': [48, 248, 3547, 3919, 4180], 'apoptosis.': [49, 161, 249, 361, 454, 1445, 3313, 3438, 3548], 'First,': [50, 250, 3549], 'stress': [52, 252, 2693, 3088, 3151], 'with': [53, 91, 253, 291, 617, 991, 1342, 1634, 1710, 1908, 1982, 2097, 2218, 2273, 2280, 2327, 2333, 2402, 2541, 2615, 3043, 3168, 3181, 3187, 3209, 3261, 3267, 3562, 3568, 3588, 3641, 4129, 4253, 4326, 4329], 'H2O2': [54, 81, 254, 281, 1967, 2851, 2942, 3005, 4330], 'led': [55, 255, 4270], 'concurrent': [57, 257], 'increases': [58, 258, 3230, 3670], 'in': [59, 64, 108, 156, 259, 264, 308, 356, 417, 440, 596, 761, 909, 920, 923, 1122, 1136, 1336, 1383, 1388, 1456, 1496, 1513, 1628, 1640, 1675, 1686, 1708, 1957, 1961, 2087, 2107, 2112, 2176, 2201, 2246, 2293, 2355, 2551, 2578, 2682, 2698, 2727, 2823, 2887, 2892, 2939, 2947, 2994, 3018, 3089, 3154, 3177, 3206, 3213, 3231, 3258, 3286, 3320, 3344, 3359, 3363, 3545, 3559, 3619, 3632, 3647, 3663, 3671, 3816, 3833, 3888, 3909, 3934, 3937, 4012, 4091, 4108, 4126, 4159, 4207, 4222, 4316], 'Mfn-2': [60, 72, 102, 168, 184, 260, 272, 302, 368, 384, 746, 902, 938, 989, 1119, 1135, 1145, 1192, 1236, 1440, 1452, 1508, 1538, 1554, 1905, 1912, 2676, 2822, 2932, 2948, 2991, 3064, 3077, 3102, 3106, 3118, 3131, 3224, 3306, 3314, 3332, 3343, 3376, 3393, 3404, 3428, 3439, 3796, 3808, 3824, 3882, 3895, 3981, 4001, 4090, 4100, 4214, 4269, 4301], 'expression': [61, 169, 261, 369, 1539, 2934, 3066, 3078, 3307], 'and': [62, 129, 146, 173, 192, 262, 329, 346, 373, 392, 405, 451, 535, 601, 664, 747, 756, 768, 907, 914, 922, 934, 1155, 1202, 1235, 1304, 1347, 1381, 1394, 1402, 1410, 1450, 1543, 1562, 1572, 1775, 1797, 1804, 1810, 1824, 1838, 1880, 1964, 1978, 2084, 2117, 2210, 2263, 2309, 2330, 2359, 2409, 2426, 2491, 2534, 2553, 2582, 2596, 2633, 2679, 2718, 2730, 2889, 2963, 2982, 3024, 3050, 3067, 3091, 3234, 3242, 3280, 3296, 3372, 3396, 3420, 3445, 3448, 3475, 3480, 3502, 3507, 3582, 3602, 3616, 3653, 3658, 3674, 3828, 3838, 4078, 4137, 4154, 4277, 4279, 4282, 4288, 4307], 'apoptosis': [63, 107, 119, 263, 307, 319, 419, 1059, 1411, 2099, 3069, 3097, 3338, 3788, 3799, 3920, 3984, 4181, 4206, 4304], 'cultured': [65, 265, 2410, 2840, 3155, 3287, 3365, 3889, 3910, 4092], 'neonatal': [66, 266, 2841, 3156, 3367, 3912, 4093], 'rat': [67, 267, 915, 1578, 2213, 2842, 3157, 3289, 3348, 3366, 3911, 4094], 'cardiomyocytes.': [68, 268, 3368, 4095], 'Second,': [69, 269], 'overexpression': [70, 131, 270, 331, 1231, 3893, 4088, 4101, 4267, 4299], 'level': [75, 275, 3134], 'similar': [76, 276, 3145], 'induced': [79, 279, 3081, 3148], 'by': [80, 122, 130, 280, 322, 330, 1587, 1658, 2094, 2105, 2337, 2344, 2361, 2508, 2612, 2659, 2936, 3014, 3029, 3040, 3082, 3100, 3149, 3201, 3228, 3237, 3256, 3415, 3669, 3800, 3985, 4087, 4246], 'was': [82, 120, 282, 320, 606, 1652, 1668, 1698, 1757, 1766, 1816, 1849, 1881, 1906, 1980, 2092, 2342, 2418, 2474, 2559, 2590, 2599, 2610, 2668, 3204, 3225, 3254, 3556, 4084, 4122], 'sufficient': [83, 174, 283, 374, 1544, 3121, 3309], 'trigger': [85, 285, 3123, 3311], 'myocyte': [86, 118, 286, 318, 2732, 2836, 3010, 3068, 3798, 4303], 'apoptosis,': [87, 181, 287, 381, 1551, 2733, 3011, 3412, 4321], 'which': [88, 288, 418, 1861, 2876, 4008], 'associated': [90, 290], 'profound': [92, 292], 'inhibition': [93, 123, 142, 293, 323, 342, 927, 3638, 3925, 4188], 'Akt': [95, 144, 295, 344, 460, 536, 1979, 3812, 4083, 4107, 4115, 4120, 4150], 'activation': [96, 136, 147, 296, 336, 347, 458, 3472, 3504, 3906, 4081, 4151], 'without': [97, 297, 4112], 'altering': [98, 298, 4113], 'ERK1/2': [99, 299, 476, 1977, 3908, 3927], 'signaling.': [100, 300, 1125, 3635], 'Third,': [101, 301], 'silencing': [103, 303, 3341], 'inhibited': [104, 304], 'stress-induced': [106, 177, 306, 377, 1547, 3337, 3434], 'H9C2': [109, 309, 2537, 3345, 3360, 3408], 'cells,': [110, 310, 3295, 3346, 3455], 'cardiac': [112, 167, 312, 367, 1497, 1537, 1654, 2214, 2828, 3290, 3349, 3890, 3913], 'cell': [114, 160, 180, 314, 360, 380, 403, 406, 422, 444, 447, 472, 540, 905, 912, 1281, 1442, 1448, 1550, 2700, 3096, 3126, 3178, 3299, 3312, 3351, 3437, 3840, 3983, 3989, 4016, 4021, 4193, 4205, 4228, 4239], 'line.': [115, 315], 'Furthermore,': [116, 316, 3197, 3655, 4139], 'Mfn-2-induced': [117, 157, 317, 357, 3229, 3611, 3787, 3935, 4156, 4220, 4227], 'abrogated': [121, 321, 3610, 4125], 'caspase-9': [125, 325, 2630, 3506, 3592, 3606, 3627, 3657], '(but': [126, 326, 3813], 'not': [127, 327, 3071, 3212, 3302, 3380, 3424, 4177], 'caspase-8)': [128, 328], 'Bcl-xL': [133, 333, 3688], 'or': [134, 334, 413, 429, 453, 1444, 1522, 1969, 1987, 2104, 2228, 2404, 3058, 3184, 3215, 3591, 3903, 4331], 'enhanced': [135, 335], 'phosphatidylinositol': [138, 338, 517, 525], '3-kinase-Akt,': [139, 339], 'suggesting': [140, 182, 340, 382, 1117, 1552], 'signaling': [145, 345, 408, 537, 591, 645, 932, 3458, 3542, 3832, 3929], 'mitochondrial': [150, 350, 753, 762, 766, 1051, 1123, 1147, 1159, 1194, 1199, 1337, 1408, 2603, 3482, 3685, 3803, 4234, 4240, 4272], 'death': [151, 351, 407, 2701, 3467, 4229], 'pathway': [152, 352, 933, 3470, 3483, 3887], 'are': [153, 353, 1349, 1890, 2644], 'essentially': [154, 354], 'involved': [155, 355, 3544, 4011], 'These': [162, 362, 3073, 3791, 4184], 'results': [163, 363, 1533, 2197, 3074, 3283, 3792, 4185], 'indicate': [164, 364, 1271, 1534, 3075, 3793], 'increased': [166, 366, 1536, 2726, 3255, 4148], 'both': [171, 371, 1233, 1407, 1541, 3238, 3577, 3656, 4076], 'necessary': [172, 372, 1542, 3334], 'deregulation': [185, 385, 1555], 'may': [186, 386, 1556], 'be': [187, 387, 425, 1557], 'pathogenic': [190, 390, 1560], 'element': [191, 391, 1561], 'potential': [194, 394, 1201, 1564, 2818, 3879], 'therapeutic': [195, 395, 1565], 'target': [196, 396, 1566, 1885], 'imbalance': [401], 'between': [402, 1400, 3599], 'survival': [404, 452, 1443, 3990, 4017, 4194], 'pathways': [409, 470, 592, 650, 3543], 'triggers': [410, 3797, 3982], 'either': [411, 426, 3589, 3648, 3901], 'proliferative': [412, 602, 662, 943], 'degenerative': [414, 600], 'disorders,': [415], 'diseases': [416, 654], '(or': [420, 3484], 'programmed': [421], 'death)': [423, 1523], 'can': [424], 'abnormally': [427], 'blocked': [428], 'undesirably': [430], 'activated.': [431], 'In': [432, 455, 978, 1126, 1229, 1972, 3636, 3678], 'this': [433, 3993], 'regard,': [434], 'Ras': [435, 590, 605, 644, 692, 3827], 'plays': [436, 1509, 2694, 3628], 'central': [438], 'role': [439, 760, 1495, 1512, 2697, 2820, 3631, 3933], 'regulation': [442, 4014], 'fate,': [445], 'including': [446, 1302], 'proliferation,': [448], 'differentiation,': [449], 'senescence,': [450], 'particular,': [456], 'Ras-mediated': [457], 'has': [461, 593, 1267, 2686], 'emerged': [462], 'as': [463, 608, 656, 1437, 1656, 1718, 1792, 1817, 1876, 1921, 1995, 2120, 2365, 2434, 2506, 2592, 2601, 2646, 3012, 3386, 3413, 3667, 4018, 4020, 4166], 'focal': [465], 'point': [466, 2194], 'signal': [468, 4195], 'transduction': [469], 'promoting': [471], 'survival,': [473], 'whereas': [474, 1187], 'Ras-activated': [475, 3830], '4The': [477], 'abbreviations': [478], 'used': [479, 1790, 2653, 2848, 3385], 'are:': [480], 'ERK,': [481], 'extracellular': [482], 'signal-regulated': [483, 532], 'kinase;': [484, 490], 'Mfn-2,': [485, 1343, 1794, 2505, 3666], 'mitofusin-2;': [486], 'MAPK,': [487], 'mitogen-activated': [488, 529], 'protein': [489, 530, 1902, 2223, 2992, 3394, 4116], 'FBS,': [491], 'fetal': [492, 1636], 'bovine': [493, 1637], 'serum;': [494], 'TUNEL,': [495], 'terminal': [496], 'deoxynucleotidyltransferase-mediated': [497], 'dUTP': [498, 2079], 'nick': [499], 'end': [500, 1853], 'labeling;': [501], 'Adv-GFP,': [502], 'adenovirus': [503, 520, 2219], 'expressing': [504, 521, 2220], 'green': [505, 2221], 'fluorescent': [506, 2222], 'protein;': [507], 'm.o.i.,': [508], 'multiplicity': [509, 2232], 'infection;': [511], 'siRNA,': [512], 'small': [513], 'interfering': [514], 'RNA;': [515], 'PI3K,': [516], '3-kinase;': [518], 'Adv-CA-PI3K,': [519], 'constitutively': [523, 4143], 'active': [524, 4144], '3-kinase': [526, 4005], 'mutant;': [527], 'MEK,': [528], 'kinase/extracellular': [531], 'kinase': [533], 'kinase.': [534], 'cascades': [538], 'drive': [539], 'cycle': [541, 1858, 1879], 'progression': [542], '(1Jun': [543], 'T.': [544, 559, 561, 1313, 1597, 2003, 2128, 2771, 2857, 2896, 4034, 4044], 'Gjoerup': [545], 'O.': [546, 715, 954, 1468, 1730, 1933, 2446, 3851, 3951], 'Roberts': [547], 'T.M.': [548], 'Sci.': [549, 794, 811, 1220, 2065, 2162, 2383, 2706], 'STKE1999.': [550], '1999;': [551, 2792, 2807, 2917, 3771], ':': [552], 'PE1PubMed': [553], 'Google': [554, 570, 585, 633, 683, 737, 786, 799, 816, 847, 870, 896, 976, 1014, 1031, 1048, 1089, 1115, 1185, 1227, 1263, 1333, 1373, 1429, 1490, 1614, 1752, 1955, 2020, 2048, 2075, 2145, 2172, 2393, 2468, 2527, 2716, 2768, 2797, 2813, 2874, 2922, 3520, 3535, 3703, 3720, 3737, 3758, 3782, 3873, 3973, 4055, 4072], 'Scholar,': [555, 571, 787, 800, 817, 848, 871, 1015, 1032, 1090, 2021, 2049, 2146, 2769, 2798, 3521, 3704, 3721, 3738, 3759, 4056], '2Takai': [556], 'Y.': [557, 713, 952, 1248, 1466, 1728, 1931, 2444, 2511, 3849, 3949], 'Sasaki': [558], 'Matozaki': [560], 'Physiol.': [562], 'Rev.': [563, 577, 625, 1021, 1038, 3527, 3710, 3727], '2001;': [564, 795, 1025, 1042, 1327, 2069, 2166, 2387, 2762, 3714, 3731, 3752, 4049, 4066], '81:': [565], '153-208Crossref': [566], 'PubMed': [567, 582, 630, 680, 734, 783, 798, 815, 844, 867, 893, 973, 1011, 1028, 1045, 1086, 1112, 1182, 1224, 1260, 1330, 1370, 1426, 1487, 1611, 1749, 1952, 2017, 2045, 2072, 2142, 2169, 2390, 2465, 2524, 2713, 2765, 2810, 2871, 3517, 3532, 3700, 3717, 3734, 3755, 3779, 3870, 3970, 4052, 4069], 'Scopus': [568, 583, 631, 681, 735, 784, 845, 868, 894, 974, 1012, 1029, 1046, 1087, 1113, 1183, 1225, 1261, 1331, 1371, 1427, 1488, 1612, 1750, 1953, 2018, 2046, 2073, 2143, 2170, 2391, 2466, 2525, 2714, 2766, 2795, 2811, 2872, 2920, 3518, 3533, 3701, 3718, 3735, 3756, 3780, 3871, 3971, 4053, 4070], '(2072)': [569], '3Malumbres': [572], 'M.': [573, 575, 621, 623, 802, 819, 833, 873, 1061, 1075, 1092, 1162, 1213, 1357, 1413, 2023, 2053, 2150, 2371], 'Barbacid': [574, 622], 'Nat.': [576, 624, 728, 967, 1020, 1037, 1481, 1743, 1946, 2459, 3709, 3726, 3864, 3964], 'Cancer.': [578, 626], '2003;': [579, 627, 864, 1221, 2521], '3:': [580, 628, 3772], '459-465Crossref': [581, 629], '(1444)': [584, 632], 'Scholar).': [586, 634, 684, 738, 977, 1228, 1264, 1374, 1430, 1615, 1753, 2076, 2173, 2394, 2469, 2814, 2923, 3536, 3974, 4073], 'Thus,': [587, 3304, 3917], 'dysfunction': [588, 666], 'been': [594, 1268], 'implicated': [595], 'multitude': [598], 'diseases.': [603], 'Originally,': [604], 'identified': [607, 688], 'viral': [610], 'oncogene': [611], 'because': [612, 701, 3353], 'its': [614, 703, 748, 981, 1493, 2958, 3476, 3931], 'relationship': [616], 'various': [618, 941, 2412, 3083, 4243], 'cancers': [619], '(3Malumbres': [620], 'Over': [635], 'past': [637], 'decade,': [638], 'increasing': [639], 'has,': [641], 'however,': [642], 'placed': [643], 'at': [646, 1050, 1620, 1827, 1851, 1860, 2230, 2257, 2321, 2406, 2429, 2495, 2960, 2972, 3270, 4259], 'center': [648], 'diverse': [652], 'cardiovascular': [653], 'such': [655], 'congestive': [657], 'failure,': [659], 'hypertensive': [660], 'vascular': [661, 916, 942, 3292, 3834, 3938], 'growth,': [663], 'endothelial': [665], '(4Chien': [667], 'K.R.': [668], 'Olson': [669], 'E.N.': [670], 'Cell.': [671, 774, 1002, 3691, 3770], '2002;': [672, 812, 841, 1083, 3514], '110:': [673], '153-162Abstract': [674], 'Full': [675, 677, 778, 780, 888, 890, 1006, 1008, 1107, 1109, 1177, 1179, 1255, 1257, 2040, 2042, 2710, 3695, 3697, 3774, 3776], 'Text': [676, 678, 779, 781, 889, 891, 1007, 1009, 1108, 1110, 1178, 1180, 1256, 1258, 2041, 2043, 2711, 3696, 3698, 3775, 3777], 'PDF': [679, 782, 892, 1010, 1111, 1181, 1259, 2044, 2712, 3699, 3778], '(137)': [682], 'We': [685, 3537], 'recently': [687, 899], 'powerful': [690], 'endogenous': [691, 2880, 2931], 'inhibitor,': [693], '(Mfn-2),': [695], 'named': [697], 'gene': [700, 1666, 2933, 3065, 3161, 3681], 'anti-proliferative': [704, 982], 'effects': [705], '(5Chen': [706, 945, 1459, 1721, 1924, 2437, 3842, 3942], 'K-H.': [707, 946, 1460, 1722, 1925, 2438, 3843, 3943], 'Guo': [708, 712, 947, 951, 1461, 1465, 1723, 1727, 1926, 1930, 2439, 2443, 3844, 3848, 3944, 3948], 'X.': [709, 721, 948, 960, 1462, 1474, 1724, 1736, 1927, 1939, 2440, 2452, 3523, 3525, 3845, 3857, 3945, 3957], 'Ma': [710, 949, 1463, 1725, 1928, 2441, 3846, 3946], 'D.': [711, 717, 806, 950, 956, 1464, 1470, 1726, 1732, 1929, 1935, 2442, 2448, 2743, 2779, 2904, 3847, 3853, 3947, 3953], 'Li': [714, 718, 953, 957, 1467, 1471, 1729, 1733, 1932, 1936, 2445, 2449, 2802, 3850, 3854, 3950, 3954], 'Yang': [716, 955, 1469, 1731, 1934, 2447, 3852, 3952], 'P.': [719, 879, 958, 1098, 1168, 1472, 1734, 1937, 2450, 2759, 3855, 3955], 'Qiu': [720, 959, 1473, 1735, 1938, 2451, 3856, 3956], 'Wen': [722, 961, 1475, 1737, 1940, 2453, 3858, 3958], 'S.': [723, 827, 877, 962, 1069, 1096, 1166, 1209, 1246, 1476, 1601, 1738, 1941, 2007, 2067, 2132, 2164, 2385, 2454, 2515, 2775, 2861, 2900, 3859, 3959], 'Xiao': [724, 963, 1477, 1598, 1739, 1942, 2004, 2032, 2060, 2129, 2157, 2378, 2455, 2858, 3860, 3960], 'R.-P.': [725, 964, 1478, 1740, 1943, 2033, 2061, 2158, 2379, 2456, 3861, 3961], 'Tang,': [726, 965, 1479, 1741, 1944, 2457, 3862, 3962], 'J.': [727, 792, 809, 838, 861, 882, 966, 1080, 1101, 1171, 1218, 1249, 1480, 1742, 1945, 2034, 2458, 2518, 2755, 3749, 3863, 3963], 'Cell': [729, 793, 810, 839, 862, 968, 1023, 1040, 1081, 1219, 1482, 1744, 1947, 2397, 2460, 3323, 3712, 3729, 3750, 3865, 3965], 'Biol.': [730, 840, 863, 883, 969, 1024, 1041, 1082, 1102, 1172, 1250, 1483, 1745, 1948, 2035, 2461, 3713, 3730, 3751, 3866, 3966], '2004;': [731, 970, 1252, 1484, 1746, 1949, 2462, 3529, 3867, 3967], '6:': [732, 971, 1485, 1747, 1950, 2463, 3868, 3968], '872-883Crossref': [733, 972, 1486, 1748, 1951, 2464, 3869, 3969], '(331)': [736, 975, 1489, 1751, 1954, 2467, 3872, 3972], 'Although': [739], 'previous': [740, 984], 'studies': [741, 985, 3820], 'shown': [743, 987, 3822], 'human': [745], 'homologs': [749], 'localize': [750], 'outer': [754], 'membrane': [755, 1200], 'play': [757], 'an': [758, 1510, 1909, 2098, 2616, 2833], 'essential': [759, 1511, 3932], 'fusion,': [763], 'thus': [764, 2734], 'regulating': [765, 1514, 2824], 'morphology': [767, 1409, 4241], 'function': [769], '(6Hales': [770], 'K.G.': [771], 'Fuller': [772, 790, 832, 1074, 1216], 'M.T.': [773, 791, 1217], '1997;': [775], '90:': [776], '121-129Abstract': [777], '(488)': [785], '7Santel': [788], 'A.': [789, 808, 829, 831, 1071, 1073, 1207, 1593, 1999, 2068, 2124, 2165, 2386, 2757, 2789, 2853, 2914, 3740, 4058], '114:': [796], '867-874Crossref': [797], '8Rojo': [801], 'Legros': [803], 'F.': [804], 'Chateau': [805], 'Lombes': [807], '115:': [813], '1663-1674Crossref': [814], '9Karbowski': [818], 'Lee': [820, 1062], 'Y.J.': [821, 1063], 'Gaume': [822, 1064, 1210], 'B.': [823, 1065, 1211, 2029, 2059, 2156, 2377, 2753], 'Jeong': [824, 1066, 1362, 1418], 'S.Y.': [825, 1067, 1363, 1419], 'Frank': [826, 1068, 1208], 'Nechushtan': [828, 1070], 'Santel': [830, 1072], 'Smith': [834, 1076, 3741], 'C.L.': [835, 1077, 3742], 'Youle': [836, 1078, 1214, 1364, 1420, 3747], 'R.J.': [837, 1079, 1215, 1365, 1421, 2055, 2152, 2373], '159:': [842, 1084], '931-938Crossref': [843, 1085], '(680)': [846, 1088], '10Chen': [849], 'H.': [850, 881, 1100, 1170, 2773, 2777, 2898, 2902, 3512], 'Detmer': [851], 'S.A.': [852], 'Ewald': [853], 'A.J.': [854, 1317], 'Griffin': [855], 'E.F.': [856], 'Fraser': [857], 'S.E.': [858, 2650], 'Chan': [859], 'D.C.': [860], '160:': [865], '189-200Crossref': [866], '(1843)': [869], '11Neuspiel': [872, 1091], 'Zunino': [874, 1093, 1163], 'R.': [875, 1094, 1164, 1244, 2801, 2805, 3748, 4040], 'Gangaraju': [876, 1095, 1165], 'Rippstein': [878, 1097, 1167], 'McBride': [880, 1099, 1169], 'Chem.': [884, 1103, 1173, 1251, 2036], '2005;': [885, 1104, 1174], '280:': [886, 1105, 1175], '25060-25070Abstract': [887, 1106, 1176], '(265)': [895, 1114, 1184], 'Scholar),': [897, 1049, 1116, 1186, 1334, 1491, 2528, 2875, 3783, 3874], 'demonstrated': [900, 2687], 'profoundly': [903, 3008, 4102], 'suppresses': [904], 'growth': [906], 'proliferation': [908, 4022], 'multiple': [910], 'tumor': [911], 'smooth': [917, 1662, 3293, 3835, 3939], 'vivo': [921], 'culture': [924, 1685], 'systems': [925], 'via': [926, 1339], 'Ras-ERK': [930], 'MAPK': [931, 1984, 3831, 3886, 3928], 'down-regulation': [936], 'contributes': [939], 'disorders': [944], 'addition': [979], 'effects,': [983], 'associates': [990], 'Bax,': [992], 'pro-apoptotic': [994, 1296, 1403], 'Bcl-2': [998, 1300], 'family': [999], '(12Green': [1000, 3689], 'D.R.': [1001, 1019, 3690, 3708], '2000;': [1003, 1608, 2014, 2037, 2139, 2868, 3692], '102:': [1004, 3693], '1-4Abstract': [1005, 3694], '(890)': [1013, 3702], '13Martinou': [1016, 3705], 'J.C.': [1017, 3706], 'Green': [1018, 1712, 1848, 3707], 'Mol.': [1022, 1039, 3711, 3728, 3769], '2:': [1026, 1043, 3715, 3732], '63-67Crossref': [1027, 3716], '(851)': [1030, 3719], '14Zamzami': [1033, 3722], 'N.': [1034, 2513, 2781, 2906, 3723, 4046], 'Kroemer': [1035, 3724], 'G.': [1036, 3725], '67-71Crossref': [1044, 3733], '(898)': [1047, 3736], 'scission': [1052], 'sites': [1053], 'during': [1054], 'initial': [1056], 'stages': [1057], '(9Karbowski': [1060], 'might': [1120, 1278, 1396], 'participate': [1121, 1335], 'apoptotic': [1124, 1241, 1389, 2190, 2699, 2837, 3036, 3127, 3221, 3252, 3457, 3634, 3804], 'contrast,': [1127, 3637], 'emerging': [1128], 'suggests': [1130], 'protective': [1132], 'effect': [1133, 3222, 3646, 3880, 3899, 3999], 'mammalian': [1137], 'cells.': [1138], 'For': [1139], 'instance,': [1140], 'dominant-active': [1142], 'form': [1143, 1190], '(promoting': [1146], 'fusion)': [1148, 1195], 'protects': [1149], 'against': [1150, 1240, 1284, 3410], 'Bax-mediated': [1151], 'cytochrome': [1152, 2557, 2563, 3493, 3554], 'c': [1153, 2550, 2558, 2564, 2609, 2618, 3443, 3555], 'release': [1154, 2565, 3491], 'reduces': [1156], 'free': [1157], 'radical-mediated': [1158], 'injury': [1160], '(11Neuspiel': [1161], 'dominant-negative': [1189], '(inhibiting': [1193], 'causes': [1196], 'fragmentation': [1203, 2091, 2341, 3027, 3051, 3199, 3235, 3613, 4158], 'mitochondria': [1205, 1277, 1355, 2888, 4317], '(15Santel': [1206], 'Herrler': [1212], '116:': [1222], '2763-2774Crossref': [1223], '(314)': [1226], 'addition,': [1230, 3679], 'Mfn-1': [1234], 'provides': [1237], 'some': [1238, 1295], 'protection': [1239], 'stimuli': [1242], '(16Sugioka': [1243], 'Shimizu': [1245], 'Tsujimoto': [1247], '279:': [1253], '52726-52734Abstract': [1254], '(291)': [1262], 'This': [1265], 'phenomenon': [1266], 'interpreted': [1269], 'high': [1273], 'levels': [1274], 'fused': [1276], 'constitute': [1279], 'defense': [1282], 'mechanism': [1283, 4199], 'accumulation': [1286], 'lesions.': [1289], 'It': [1290, 3001], 'noteworthy': [1293, 3003], 'members': [1297], 'Bax': [1303, 1346, 1380, 1393], 'Bak': [1305, 1348, 1382, 1395], '(17Wei': [1306], 'M.C.': [1307], 'Zong': [1308], 'W.X.': [1309], 'Cheng': [1310], 'E.H.': [1311], 'Lindsten': [1312], 'Panoutsakopoulou': [1314], 'V.': [1315], 'Ross': [1316], 'Roth': [1318], 'K.A.': [1319], 'MacGregor': [1320], 'G.R.': [1321], 'Thompson': [1322, 3767], 'C.B.': [1323, 3768], 'Korsmeyer': [1324], 'S.J.': [1325], 'Science.': [1326, 2479, 3513], '292:': [1328], '727-730Crossref': [1329], '(3373)': [1332], 'fusion': [1338], 'their': [1340], 'interaction': [1341], 'indicating': [1344, 3426, 3625], 'required': [1350, 3431], 'normal': [1352, 1384], 'morphogenesis': [1353], '(18Karbowski': [1356, 1412], 'Norris': [1358, 1414], 'K.L.': [1359, 1415], 'Cleland': [1360, 1416], 'M.M.': [1361, 1417], 'Nature.': [1366, 1422], '2006;': [1367, 1423], '443:': [1368, 1424], '658-662Crossref': [1369, 1425], '(532)': [1372, 1428], 'The': [1375, 1647, 1788, 1813, 1844, 1857, 1887, 2267, 2629, 2945, 3035, 3220, 3605], 'functionally': [1376], 'opposing': [1377], 'roles': [1378], 'versus': [1386], 'those': [1387, 3185, 3265, 4327], 'suggest': [1391, 4186], 'undergo': [1397], 'conformational': [1398], 'change': [1399], 'anti-': [1401], 'conformations': [1404], 'regulate': [1406], 'Nevertheless,': [1431], 'it': [1432], 'still': [1433], 'remains': [1434], 'highly': [1435], 'controversial': [1436], 'whether': [1439, 1507, 3115, 3331, 4226, 4312], 'promotes': [1441], 'Of': [1446], 'all': [1447, 2623], 'types': [1449], 'tissues,': [1451], 'expressed': [1454, 2645], 'predominantly': [1455], 'but': [1492, 3211, 3379], 'functional': [1494, 2819], 'myocytes': [1498, 1580, 1617, 1655, 2215, 3207, 3785, 3914], 'poorly': [1500], 'understood.': [1501], 'sought': [1504, 3328, 3538], 'determine': [1506, 3114, 3330, 3540, 4311], 'fate': [1516, 2826], '(survival': [1521], 'and,': [1524], 'if': [1525], 'so,': [1526], 'explore': [1528], 'underlying': [1530], 'mechanism.': [1531], 'Our': [1532], 'Isolation,': [1570], 'Culture,': [1571], 'Adenoviral': [1573], 'Infection': [1574, 3165], 'Cardiac': [1576, 1616, 2089, 3111, 3322], 'Myocytes—Neonatal': [1577], 'ventricular': [1579], 'were': [1581, 1618, 1791, 2184, 2216, 2244, 2271, 2291, 2400, 2432, 2529, 2539, 2576, 2625, 2638, 3284, 3660, 4324], 'isolated': [1582], 'from': [1583, 1959, 2181, 2198, 2476, 2627, 2640, 3786], '1-day-old': [1584], 'Sprague-Dawley': [1585], 'rats': [1586], 'method': [1589], 'described': [1590, 1719, 1922, 1996, 2121, 2366, 2435, 2507], 'previously': [1591, 1720, 1923, 1997, 2122, 2367, 2436, 2509], '(19Chesley': [1592, 1998, 2123, 2852], 'Lundberg': [1594, 2000, 2125, 2854], 'M.S.': [1595, 2001, 2126, 2855], 'Asai': [1596, 2002, 2127, 2856], 'R-P.': [1599, 2005, 2130, 2859], 'Ohtani': [1600, 2006, 2131, 2860], 'Lakatta': [1602, 2008, 2133, 2862], 'E.G.': [1603, 2009, 2134, 2863], 'Crow': [1604, 2010, 2135, 2864], 'M.T': [1605, 2011, 2136, 2865], 'Circ.': [1606, 2012, 2137, 2760, 2790, 2866, 2915], 'Res.': [1607, 2013, 2138, 2761, 2791, 2867, 2916], '87:': [1609, 2015, 2140, 2869], '1172-1179Crossref': [1610, 2016, 2141, 2870], '(348)': [1613, 2019, 2144, 2873], 'plated': [1619], 'density': [1622], '6.6': [1624], '×': [1625], '104': [1626], 'cells/cm2': [1627], "Dulbecco's": [1629, 1677, 1687], 'modified': [1630, 1678, 1688], "Eagle's": [1631, 1679, 1689], 'medium': [1632, 1680, 1690, 2248], 'supplemented': [1633], '10%': [1635, 1692, 3904], 'serum': [1638, 3055], '(FBS)': [1639], 'presence': [1642, 1963], '0.1': [1644], 'mm': [1645, 2109, 2297, 2302, 2305], '5-bromo-2-deoxyuridine.': [1646], 'purity': [1648], 'these': [1650], 'cultures': [1651], '>98%': [1653], 'indexed': [1657], 'positive': [1659], 'staining': [1660, 2096, 2364, 3244, 3422], 'α-actin.': [1664], 'Adenovirus-mediated': [1665], 'transfer': [1667, 3162, 3682], 'implemented': [1669], 'after': [1670, 2314, 2952, 2996], '24': [1671, 2974, 2997], 'h': [1672, 1683, 2240, 2326, 2954, 2998, 3575, 3596], 'quiescence': [1674], 'serum-free': [1676, 2247], 'following': [1681, 1784, 2570], '48': [1682, 2318, 3275, 3595], 'containing': [1691, 2249], 'FBS.': [1693], 'Real-time': [1694], 'PCR—Quantitative': [1695], 'real-time': [1696, 2937], 'PCR': [1697, 1814], 'performed': [1699, 1907], 'using': [1700, 1759, 1772, 2561, 2839, 3159, 3339], 'DNA': [1702, 2289, 2340, 2350, 3026, 3030, 3198, 3202, 3416, 3612, 4157], 'Engine': [1703], 'Opticon': [1704], 'system': [1705], '(MJ': [1706], 'Research)': [1707], 'combination': [1709], 'SYBR': [1711, 1847], '(Roche': [1713], 'Applied': [1714, 2478], 'Science,': [1715], 'Mannheim,': [1716], 'Germany)': [1717], 'Briefly,': [1754, 2574], 'total': [1755, 2349, 4114], 'RNA': [1756, 1765, 2482], 'extracted': [1758, 2332], 'TriReagent': [1760], '(Sigma).': [1761], '1.5': [1762], 'μg': [1763, 2347], 'then': [1767, 2264, 2331, 2964], 'reverse-transcribed': [1768], 'first-strand': [1770], 'cDNA': [1771], 'oligo(dT)': [1773], 'primer': [1774], 'Moloney': [1776], 'murine': [1777], 'leukemia': [1778], 'virus': [1779], 'reverse': [1780], 'transcriptase': [1781], '(Promega': [1782], 'Corp.)': [1783], "manufacturer's": [1786, 2547, 2572], 'protocol.': [1787, 2548], 'primers': [1789], 'follows:': [1793, 1818], '5′-CTCAGGAGCAGCGGGTTTATTGTCT-3′': [1795], '(forward)': [1796, 1809], '5′-TGTCGAGGGACCAGCATGTCTATCT-3′': [1798], '(reverse),': [1799], 'producing': [1800], '412-bp': [1802], 'fragment;': [1803], '18': [1805], 'S': [1806], 'RNA,': [1807], '5′-GGAAGGGCACCACCAGGAGT-3′': [1808], '5′-TGCAGCCCCGGACATCTAAG-3′': [1811], '(reverse).': [1812], 'profile': [1815], '95': [1819, 1828], '°C': [1820, 1829, 1834, 1840, 2259, 2323, 4261], '30': [1822, 1831, 1836, 1842], 's': [1823], '35': [1825], 'cycles': [1826], 's,': [1832, 1837], '60': [1833], '72': [1839], 's.': [1843], 'amount': [1845], 'measured': [1850, 1981, 2433, 2560], 'each': [1855, 2182, 2192, 2496], 'cycle.': [1856], 'number': [1859], 'emission': [1863], 'intensity': [1864], 'sample': [1867], 'rose': [1868], 'above': [1869], 'base': [1871, 3140], 'line': [1872], 'referred': [1874], 'threshold': [1878], 'proportional': [1882], 'concentration.': [1886], 'data': [1888, 2193], 'presented': [1889], 'average': [1892, 2984], 'four': [1894, 2202], 'independent': [1895, 2205], 'experiments.': [1896, 2206], 'Western': [1897, 2613], 'Blotting—Western': [1898], 'blotting': [1899, 2614], 'assess': [1901], 'abundance': [1903, 2950, 2993, 3395], 'affinity-purified': [1910], 'anti-chicken': [1911], 'primary': [1913, 3364, 3802, 4198], 'antibody': [1914, 1986, 1990], '(GenWay': [1915], 'Biotech,': [1916], 'Inc.,': [1917], 'San': [1918], 'Diego,': [1919], 'California)': [1920], 'Scholar)': [1956, 2717], 'samples': [1958], 'cardiomyocytes': [1960, 2270, 2843, 3158, 3167, 3253, 3587], 'absence': [1965], 'treatment': [1968], 'adenoviral': [1970, 2315, 3160, 3680], 'infection.': [1971], 'subset': [1973], 'experiments,': [1974], 'phosphorylation': [1975, 4105, 4121], 'anti-phospho-p44/42': [1983], 'Thr202/Tyr204': [1985], 'anti-phospho-Akt': [1988], 'Ser473': [1989], '(Cell': [1991], 'Signaling': [1992], 'Biotechnology,': [1993], 'Inc.)': [1994], '20Zheng': [2022], 'Zhang': [2024], 'S-J.': [2025], 'Zhu': [2026], 'W.-Z': [2027], 'Ziman': [2028], 'Kobilka': [2030, 2058, 2155, 2376], 'B.K.': [2031], '275:': [2038], '40635-40640Abstract': [2039], '(105)': [2047], '21Zhu': [2050, 2147], 'W-Z.': [2051, 2148, 2369], 'Zheng': [2052, 2149, 2370], 'Lefkowitz': [2054, 2151, 2372], 'Koch': [2056, 2153, 2374], 'W.J.': [2057, 2154, 2375], 'Proc.': [2062, 2159, 2380], 'Natl.': [2063, 2160, 2381], 'Acad.': [2064, 2161, 2382], 'U.': [2066, 2163, 2384], '98:': [2070, 2167, 2388], '1607-1612Crossref': [2071, 2168, 2389], '(383)': [2074, 2171, 2392], 'Terminal': [2077], 'Deoxynucleotidyltransferase-mediated': [2078], 'Nick': [2080], 'End': [2081], 'Labeling': [2082, 2209], '(TUNEL)': [2083], 'Hoechst': [2085, 2110, 3239, 3421, 3620], 'Staining': [2086], 'Cultured': [2088, 2683], 'Myocytes—Nuclear': [2090], 'detected': [2093, 2343, 2611, 3205], 'TUNEL': [2095, 3019, 3041, 3243], 'detection': [2100], 'kit': [2101, 2473, 2568], '(R&D': [2102], 'Systems)': [2103], 'incubation': [2106], '10': [2108, 2177, 2304, 2346], '33342': [2111], 'fixed': [2113], '(70%': [2115], 'alcohol': [2116], '30%': [2118], 'acetone)': [2119], '500–700': [2174], 'randomly': [2178], 'chosen': [2179], 'fields': [2180], 'dish': [2183], 'counted': [2185], 'percentage': [2188, 3250], 'nuclei;': [2191], 'shows': [2195, 2978], '5000–7000': [2199], 'eight': [2204], 'MitoTracker': [2207, 2252, 4256], 'Red': [2208, 2253, 4257], 'Confocal': [2211], 'Imaging—Neonatal': [2212], 'infected': [2217, 2401, 3186, 3208, 3260, 3266, 3561, 3567, 4128], '(Adv-GFP;': [2224], 'control': [2226, 3189, 4173], 'virus)': [2227], 'Adv-Mfn-2': [2229, 2405, 3169, 3262, 3563, 4130], 'infection': [2234, 2316], '(m.o.i.)': [2235], '100.': [2237], 'After': [2238, 2586], '24–48': [2239], 'infection,': [2242], 'incubated': [2245, 2320, 4252], '0.2': [2250, 4254], 'μm': [2251, 4255], 'CMXRos': [2254, 4258], '(Molecular': [2255], 'Probes)': [2256], '37': [2258, 4260], '20': [2261, 4263], 'min': [2262], 'washed': [2265], 'twice.': [2266], 'intact': [2268], '(unfixed)': [2269], 'imaged': [2272], 'Zeiss': [2275], '510': [2276], 'inverted': [2277], 'confocal': [2278, 4247], 'microscope': [2279], '×40': [2282], 'numerical': [2283], 'aperture': [2284], '1.3': [2285], 'oil': [2286], 'immersion': [2287], 'lens.': [2288], 'Laddering—Cells': [2290], 'lysed': [2292, 2577], 'lysis': [2294], 'buffer': [2295, 2358, 2581], '(10': [2296], 'Tris-Cl': [2298], '(pH': [2299], '8.0),': [2300], '150': [2301], 'NaCl,': [2303], 'EDTA,': [2306], '0.4%': [2307], 'SDS,': [2308], '100': [2310, 2408, 3273, 3572], 'μg/ml': [2311], 'protease': [2312], 'K)': [2313], 'h;': [2319], '50': [2322], '5': [2325], 'gentle': [2328], 'agitation;': [2329], 'phenol/CHCl3/isoamyl': [2334], 'alcohol,': [2335], 'followed': [2336, 2658], 'CHCl3/isoamyl': [2338], 'alcohol.': [2339], 'loading': [2345], 'onto': [2351], '2%': [2352], 'agarose': [2353], 'gel': [2354], 'Tris': [2356], 'acetate/EDTA': [2357], 'visualized': [2360, 4237], 'ethidium': [2362], 'bromide': [2363, 2417, 2472], '(21Zhu': [2368], '3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [2395], 'Bromide': [2396], 'Viability': [2398], 'Assay—Cells': [2399], 'Adv-GFP': [2403, 3191, 3268, 3569], 'm.o.i.': [2407, 3271], 'times.': [2413, 2585], '0.5': [2414], 'mg/ml': [2415], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [2416, 2471], 'added': [2419], '4': [2424, 2953], 'h,': [2425, 2962], 'absorbances': [2428], '490': [2430], 'nm': [2431], 'A': [2470, 3581], 'purchased': [2475, 2626, 2639], 'Roche': [2477], 'Small': [2480], 'Interfering': [2481], '(siRNA)—For': [2483], 'siRNA': [2484, 3354, 3377, 3383, 3405], 'assay,': [2485], '21-nucleotide': [2486], 'siRNAs': [2487], 'comprising': [2488], '19': [2489], 'nucleotides': [2490], 'dTdT': [2493], 'overhang': [2494], '3′': [2497], 'terminus': [2498], 'corresponding': [2499], 'coding': [2501], 'region': [2502], '1973–1991': [2503], '(22Eura': [2510], 'Ishihara': [2512], 'Yokota': [2514], 'Mihara': [2516], 'K.': [2517, 2783, 2785, 2787, 2908, 2910, 2912, 4028, 4032, 4042], 'Biochem.': [2519, 2705, 3528], '(Tokyo).': [2520], '134:': [2522], '333-344Crossref': [2523], '(319)': [2526], 'chemically': [2530], 'synthesized:': [2531], 'RNAi-1,': [2532], '5′-AGAGGGCCUUCAAGCGCCATT-3′;': [2533], 'RNAi-2,': [2535], '5′-UGGCGCUUGAAGGCCCUCUTT-3′.': [2536], 'transfected': [2540], 'Oligofectamine': [2542], '(Lifetech)': [2543], 'according': [2544], 'Cytochrome': [2549, 2608, 3442], 'Cytosolic': [2552], 'Mitochondrial': [2554, 3441, 4223], 'Fractions—Release': [2555], 'Apoptosis': [2566, 2681, 3319], 'Assay': [2567], '(Oncogene)': [2569], 'instructions.': [2573], 'cytosol': [2579], 'extract': [2580], 'homogenized': [2583], '40': [2584], 'centrifugation,': [2587], 'supernatant': [2589], 'collected': [2591], 'cytosolic': [2594, 3553], 'fraction,': [2595], 'pellet': [2598], 'resuspended': [2600], 'fraction': [2604], '(see': [2605], 'Fig.': [2606, 2924, 2976, 3369, 4096], '4A).': [2607], 'anti-cytochrome': [2617], 'antibody.': [2619], 'Materials—Unless': [2620], 'indicated': [2621], 'otherwise,': [2622], 'chemicals': [2624], 'Sigma.': [2628], 'inhibitor': [2631, 2636, 3593, 3607], 'Z-LEHD-FMK': [2632, 3608], 'caspase-8': [2635, 3474, 3590, 3640], 'Z-IE(OMe)TD(OMe)-FMK': [2637, 3642], 'Calbiochem.': [2641], 'Statistical': [2642, 2651], 'Analysis—Data': [2643], 'mean': [2648], '±': [2649, 3136], 'comparisons': [2652], 'one-way': [2654], 'analysis': [2655], 'variance,': [2657], "Bonferroni's": [2660], 'procedure': [2661], 'multiple-group': [2663], 'comparisons.': [2664], 'p': [2665], '<': [2666], '0.05': [2667], 'considered': [2669], 'statistically': [2670], 'significant.': [2671], 'Oxidative': [2672, 3317], 'Stress': [2673], 'Elevates': [2674], 'Endogenous': [2675], 'Gene': [2677], 'Expression': [2678], 'Triggers': [2680], 'Cardiomyocytes—Mounting': [2684], 'reactive': [2689, 2720, 2883], 'oxygen': [2690, 2721, 2884], 'species-mediated': [2691], '(23Jacobson': [2702], 'M.D.': [2703], 'Trends': [2704], '1996;': [2707], '21:': [2708], '83-86Abstract': [2709], '(730)': [2715], 'species': [2722, 2885], 'formation': [2723], 'greatly': [2725, 2890], 'failure': [2729, 2741, 2894], 'initiates': [2731], 'contributing': [2735], 'development': [2738], '(24Cesselli': [2742], 'Jakoniuk': [2744], 'I.': [2745, 3744, 4036], 'Barlucchi': [2746], 'L.': [2747], 'Beltrami': [2748], 'A.P.': [2749], 'Hintze': [2750], 'T.H.': [2751], 'Nadal-Ginard': [2752], 'Kajstura': [2754], 'Leri': [2756], 'Anversa': [2758], '89:': [2763], '279-286Crossref': [2764], '(326)': [2767], '25Ide': [2770], 'Tsutsui': [2772, 2897], 'Kinugawa': [2774, 2899], 'Utsumi': [2776, 2901], 'Kang': [2778, 2903], 'Hattori': [2780, 2905], 'Uchida': [2782, 2907], 'Arimura': [2784, 2909], 'Egashira': [2786, 2911], 'Takeshita': [2788, 2913], '5:': [2793, 2918], '357-363Crossref': [2794, 2919], '(575)': [2796, 2921], '26von': [2799], 'Harsdorf': [2800], 'P.F.': [2803], 'Dietz': [2804], 'Circulation.': [2806], '99:': [2808], '2934-2941Crossref': [2809], '(515)': [2812], 'To': [2815, 3992, 4309], 'investigate': [2816], 'myocytes,': [2829, 3291], 'first': [2831], 'adopted': [2832], 'model': [2838], 'subjected': [2844], 'widely': [2847], 'insult,': [2850], 'source': [2881], 'produced': [2886], 'augmented': [2891, 3063], '(25Ide': [2895], '1A': [2925], 'illustrates': [2926, 3374, 4098], 'time': [2928], 'course': [2929], '(quantified': [2935], 'PCR)': [2938], 'response': [2940, 2986], '(200': [2943, 3006], 'μm).': [2944], 'increase': [2946, 2970, 3017, 3618], 'mRNA': [2949], 'occurred': [2951], 'treatment,': [2956], 'reached': [2957], 'maximum': [2959], '8': [2961], 'declined': [2965], 'sustained': [2968], '2-fold': [2969], 'least': [2973], 'h.': [2975], '1B': [2977], 'typical': [2980], 'example': [2981], 'dose': [2985], 'H2O2-induced': [2988, 3398, 3411], 'augmentation': [2989], 'treatment.': [3000], 'μm)': [3007], 'promoted': [3009], 'evidenced': [3013, 3668], '6.2-fold': [3016], 'staining-positive': [3020, 3621], '(Fig.': [3022, 3033, 3052, 3152, 3163, 3195, 3218, 3240, 3245, 3277, 3418, 3579, 3614, 3623, 3650, 3676, 3789, 3915, 4134, 4152, 4163, 4182, 4285], '1C)': [3023], 'severe': [3025, 3093], 'revealed': [3028, 3236], 'laddering': [3031, 3417], 'assay': [3032, 3649], '1D).': [3034], 'nuclei': [3037], 'appeared': [3038], 'blue': [3039], 'staining,': [3042], 'varying': [3045], 'degree': [3046], 'chromatin': [3048, 3232], 'condensation': [3049, 3233], '1C).': [3053], 'Similarly,': [3054], 'starvation,': [3056], 'hypoxia,': [3057], 'simulated': [3059], 'ischemia': [3060], 'concurrently': [3062], '(data': [3070, 3301, 3423], 'shown).': [3072, 3303], 'markedly': [3080, 3557, 4085], 'death-inducing': [3084], 'stimuli,': [3085], 'particularly': [3086], 'cardiomyocytes,': [3090], 'accompanied': [3099], 'elevated': [3101, 3558, 3795], 'expression.': [3103], 'Up-regulation': [3104], 'Is': [3107, 4217], 'Sufficient': [3108], 'Trigger': [3110], 'Myocyte': [3112], 'Apoptosis—To': [3113], 'up-regulation': [3116, 3399, 3429], 'alone': [3119], 'death,': [3128], 'overexpressed': [3130], '(2.35': [3135], '0.47-fold': [3137], 'over': [3138], 'line;': [3141], 'n': [3142], '=': [3143, 3171, 3193, 3272, 3571, 4132], '4)': [3144], '1B)': [3153], '2A).': [3164], '(m.o.i.': [3170, 3192, 3570, 4131], '100)': [3172, 3194, 4133], 'displayed': [3173], 'time-dependent': [3175], 'decrease': [3176], 'viability': [3179], 'compared': [3180, 4325], 'uninfected': [3182, 3214], 'virus,': [3190], '2B).': [3196], '(assayed': [3200], 'laddering)': [3203], 'Adv-Mfn-2,': [3210], 'Adv-GFP-infected': [3216], '2C).': [3219], 'further': [3226, 4310], 'manifested': [3227], '2D)': [3241], '2E).': [3246], 'On': [3247], 'average,': [3248], '2–3-fold': [3257], 'relative': [3263, 3564], '(both': [3269], 'h)': [3276], '2,': [3278], 'D': [3279], 'E).': [3281], 'Similar': [3282], 'observed': [3285], 'adult': [3288], 'cancer': [3298, 3839], 'excessive': [3305], 'Silencing': [3315], 'Blocks': [3316], 'Stress-induced': [3318], 'Line': [3324], '(H9C2': [3325], 'Cells)—Next,': [3326], 'siRNA-mediated': [3340], 'line,': [3352], 'transfection': [3355], 'efficiency': [3356], 'greater': [3358], 'than': [3362], '3': [3370], '(A': [3371], 'B)': [3373], '(siRNA+),': [3378], 'scrambled': [3382], '(siRNA-;': [3384], 'negative': [3388, 4168], 'control),': [3389], 'substantially': [3390], 'reduced': [3391], 'basal': [3392, 3902, 4077, 4104], 'prevented': [3397], 'Mfn-2.': [3401], 'More': [3402], 'important,': [3403], 'fully': [3406], 'protected': [3407, 3784], 'assayed': [3414], '3C)': [3419], 'shown),': [3425], 'Increases': [3440], 'Release': [3444], 'Activates': [3446], 'Caspase-9': [3447], 'Caspase-3—As': [3449], 'case': [3452], 'most': [3454], 'upstream': [3456], 'often': [3460], 'classified': [3461], 'into': [3462], 'two': [3463], 'general': [3464], 'pathways:': [3465], 'ligand': [3468], 'receptor-mediated': [3469], 'involving': [3471, 3488], 'downstream': [3477, 3508], 'executioner': [3478, 3509], 'caspases': [3479, 3510], 'intrinsic': [3486], 'pathway)': [3487], 'sequentially': [3489], 'c,': [3494], 'recruitment': [3496], 'Apaf-1': [3498], '(apoptotic': [3499], 'protease-activating': [3500], 'factor-1),': [3501], '(27Wajant': [3511], '296:': [3515], '1635-1636Crossref': [3516], '(728)': [3519], '28Jiang': [3522], 'Wang': [3524], 'Annu.': [3526], '73:': [3530], '87-106Crossref': [3531], '(1138)': [3534], 'Mfn-2-mediated': [3546, 3918, 4179, 4202, 4320], 'found': [3551], '36': [3574], 'groups)': [3578], '4,': [3580, 3651], 'B).': [3583], 'Moreover,': [3584, 4118], 'treated': [3586, 4328], 'distinguish': [3598], 'mitochondrion-dependent': [3601], '-independent': [3603], 'pathways.': [3604], 'effectively': [3609], '4C)': [3615], '4D),': [3624], 'Mfn-2-evoked': [3633], 'had': [3643, 3896], 'no': [3644, 3897], 'detectable': [3645, 3898], 'C': [3652, 4136], 'D).': [3654, 4138], 'caspase-3': [3659], 'overtly': [3661], 'activated': [3662], 'overexpressing': [3665], 'cleaved': [3672], 'procaspase-9': [3673], 'procaspase-3': [3675], '4E).': [3677], 'anti-apoptotic': [3686], 'protein,': [3687], '29Nechushtan': [3739], 'Lamensdorf': [3743], 'Yoon': [3745], 'S.H.': [3746], '153:': [3753], '1265-1276Crossref': [3754], '(403)': [3757], '30Vander': [3760], 'Heiden': [3761], 'M.G.': [3762], 'Chandel': [3763], 'N.S.': [3764], 'Schumacker': [3765], 'P.T.': [3766], '159-167Abstract': [3773], '(453)': [3781], '4F).': [3790], 'pathway.': [3805], 'Overexpression': [3806], 'Inhibits': [3809], 'Activation': [3810], 'Not': [3814], 'ERK1/2)': [3815], 'Cardiomyocytes—Because': [3817], 'our': [3818], 'recent': [3819], 'binds': [3825], 'inhibits': [3829], 'here': [3875], 'examined': [3877, 3977], 'on': [3883, 3900, 4002], 'Ras-ERK1/2': [3885], 'myocytes.': [3891], 'Surprisingly,': [3892], 'FBS-induced': [3905], '5A).': [3916], 'unlikely': [3922], 'attributable': [3923], 'despite': [3930], 'anti-proliferation': [3936], 'Next,': [3975], 'possibility': [3979], 'suppressing': [3986], 'other': [3987], 'Ras-dependent': [3988], 'signals.': [3991], 'end,': [3994], 'defined': [3996], 'possible': [3998], 'Ras-phosphatidylinositol': [4004], '(PI3K)-Akt': [4006], 'pathway,': [4007], 'crucially': [4010], 'well': [4019], '(31Chen': [4023], 'W.S.': [4024], 'Xu': [4025], 'P.Z.': [4026], 'Gottlob': [4027], 'Chen': [4029], 'M.L.': [4030], 'Sokol': [4031], 'Shiyanova': [4033], 'Roninson': [4035], 'Weng': [4037], 'W.': [4038], 'Suzuki': [4039], 'Tobe': [4041], 'Kadowaki': [4043], 'Hay': [4045], 'Genes': [4047], 'Dev.': [4048], '15:': [4050], '2203-2208Crossref': [4051], '(783)': [4054], '32Brunet': [4057], 'Datta': [4059], 'S.R.': [4060], 'Greenberg': [4061], 'M.E.': [4062], 'Curr.': [4063], 'Opin.': [4064], 'Neurobiol.': [4065], '11:': [4067], '297-305Crossref': [4068], '(1016)': [4071], 'Unlike': [4074], 'ERK1/2,': [4075], 'mitogenic': [4079], 'stimulus-induced': [4080], 'attenuated': [4086], '5B': [4097], 'suppressed': [4103], 'titer-dependent': [4110], 'manner': [4111], 'abundance.': [4117], 'serum-mediated': [4119], 'largely': [4124], '5,': [4135], 'coexpression': [4140, 4170], 'PI3K': [4145], 'mutant': [4146], '(Adv-CA-PI3K)': [4147], 'PI3K-mediated': [4149], '5E)': [4153], 'abolished': [4155], 'co-infected': [4161], '5F).': [4164, 4183], 'Used': [4165], 'control,': [4169], 'gene,': [4174], 'β-galactosidase,': [4175], 'did': [4176], 'affect': [4178], 'Ras-evoked': [4191], 'PI3K-Akt': [4192], 'constitutes': [4196], 'responsible': [4200], 'context': [4209], 'myocardial': [4211], 'stress.': [4213], 'Apoptotic': [4215], 'Effect': [4216], 'Independent': [4218], 'Alterations': [4221], 'Morphology—To': [4224], 'address': [4225], 'causally': [4231], 'related': [4232], 'dynamics,': [4235], 'living': [4238], 'under': [4242, 4294], 'experimental': [4244, 4297], 'conditions': [4245], 'microscopic': [4248], 'imaging': [4249], 'min.': [4264], 'Interestingly,': [4265], 'adenovirus-mediated': [4266], 'perinuclear': [4273], 'clustering': [4274], '(24-h': [4275], 'infection)': [4276], 'elongation': [4278], 'networks': [4280], '(36-': [4281], '48-h': [4283], 'infections)': [4284], '6,': [4286], 'B': [4287], 'C),': [4289], 'instead': [4290], 'fragmentation,': [4292], 'although': [4293], 'same': [4296], 'conditions,': [4298], 'triggered': [4302], '(Figs.': [4305], '2': [4306], '4).': [4308], 'morphological': [4314], 'changes': [4315], 'contribute': [4318], 'Adv-Mfn-2-infected': [4322], 'co-infecte': [4332]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2043723940', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 16}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-15T09:47:26.403383', 'created_date': '2016-06-24'}
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