Title: Stress echocardiography. From pathophysiological toy to diagnostic tool.
Abstract: HomeCirculationVol. 85, No. 4Stress echocardiography. From pathophysiological toy to diagnostic tool. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBStress echocardiography. From pathophysiological toy to diagnostic tool. E Picano E PicanoE Picano CNR Institute of Clinical Physiology, Pisa, Italy. Originally published1 Apr 1992https://doi.org/10.1161/01.CIR.85.4.1604Circulation. 1992;85:1604–1612 Previous Back to top Next FiguresReferencesRelatedDetailsCited By Cotrim C, Café H, João I, Cotrim N, Guardado J, Cotrim H, Cordeiro P and Baquero L (2022) Exercise stress echocardiography: Where are we now?, World Journal of Cardiology, 10.4330/wjc.v14.i2.64, 14:2, (64-82), Online publication date: 26-Feb-2022. Yamagishi M, Tamaki N, Akasaka T, Ikeda T, Ueshima K, Uemura S, Otsuji Y, Kihara Y, Kimura K, Kimura T, Kusama Y, Kumita S, Sakuma H, Jinzaki M, Daida H, Takeishi Y, Tada H, Chikamori T, Tsujita K, Teraoka K, Nakajima K, Nakata T, Nakatani S, Nogami A, Node K, Nohara A, Hirayama A, Funabashi N, Miura M, Mochizuki T, Yokoi H, Yoshioka K, Watanabe M, Asanuma T, Ishikawa Y, Ohara T, Kaikita K, Kasai T, Kato E, Kamiyama H, Kawashiri M, Kiso K, Kitagawa K, Kido T, Kinoshita T, Kiriyama T, Kume T, Kurata A, Kurisu S, Kosuge M, Kodani E, Sato A, Shiono Y, Shiomi H, Taki J, Takeuchi M, Tanaka A, Tanaka N, Tanaka R, Nakahashi T, Nakahara T, Nomura A, Hashimoto A, Hayashi K, Higashi M, Hiro T, Fukamachi D, Matsuo H, Matsumoto N, Miyauchi K, Miyagawa M, Yamada Y, Yoshinaga K, Wada H, Watanabe T, Ozaki Y, Kohsaka S, Shimizu W, Yasuda S and Yoshino H (2021) JCS 2018 Guideline on Diagnosis of Chronic Coronary Heart Diseases, Circulation Journal, 10.1253/circj.CJ-19-1131, 85:4, (402-572), Online publication date: 25-Mar-2021. Almeida A, Carpenter J, Cameli M, Donal E, Dweck M, Flachskampf F, Maceira A, Muraru D, Neglia D, Pasquet A, Plein S, Gerber B, Buechel R, Buechel R, Delgado V, Sade L, Stankovic I, Cosyns B and Edvardsen T (2021) Multimodality imaging of myocardial viability: an expert consensus document from the European Association of Cardiovascular Imaging (EACVI), European Heart Journal - Cardiovascular Imaging, 10.1093/ehjci/jeab053, 22:8, (e97-e125), Online publication date: 20-Jul-2021. Edwards N, Scalia G, Putrino A, Appadurai V, Sabapathy S, Anderson B, Chamberlain R, Khandheria B and Chan J (2021) Myocardial work and left ventricular contractile reserve during stress echocardiography: An angiographic validation, Echocardiography, 10.1111/echo.15194, 38:10, (1711-1721), Online publication date: 1-Oct-2021. Cortigiani L, Ciampi Q, Lombardo A, Rigo F, Bovenzi F and Picano E (2019) Age- and Gender-Specific Prognostic Cutoff Values of Coronary Flow Velocity Reserve in Vasodilator Stress Echocardiography, Journal of the American Society of Echocardiography, 10.1016/j.echo.2019.05.020, 32:10, (1307-1317), Online publication date: 1-Oct-2019. Picano E, Morrone D, Scali M, Huqi A, Coviello K and Ciampi Q Integrated quadruple stress echocardiography, Minerva Cardioangiologica, 10.23736/S0026-4725.18.04691-1, 67:4 Pargaonkar V, Kobayashi Y, Kimura T, Schnittger I, Chow E, Froelicher V, Rogers I, Lee D, Fearon W, Yeung A, Stefanick M and Tremmel J (2019) Accuracy of non-invasive stress testing in women and men with angina in the absence of obstructive coronary artery disease, International Journal of Cardiology, 10.1016/j.ijcard.2018.10.073, 282, (7-15), Online publication date: 1-May-2019. Paterni M, Carpeggiani C, Ciampi C, Citro R, Antonini-Canterin F, Colonna P and Picano E (2019) Software integral de eco estrés para protocolo ABCDE de última generación, Revista Argentina de Cardiologia, 10.7775/rac.es.v87.i6.16647, 87:6, (478-484), Online publication date: 1-Dec-2019. Picano E and Scali M (2018) Stress Echocardiography, Carotid Arteries, and More, JACC: Cardiovascular Imaging, 10.1016/j.jcmg.2017.01.023, 11:2, (181-183), Online publication date: 1-Feb-2018. Mandoli G, Cameli M, Minardi S, Crudele F, Lunghetti S and Mondillo S (2018) Layer-specific strain in dipyridamole stress echo: A new tool for the diagnosis of microvascular angina, Echocardiography, 10.1111/echo.14180, 35:12, (2005-2013), Online publication date: 1-Dec-2018. Picano E, Ciampi Q, Wierzbowska-Drabik K, Urluescu M, Morrone D and Carpeggiani C (2018) The new clinical standard of integrated quadruple stress echocardiography with ABCD protocol, Cardiovascular Ultrasound, 10.1186/s12947-018-0141-z, 16:1, Online publication date: 1-Dec-2018. Cortigiani L, Carpeggiani C, Sicari R, Michelassi C, Bovenzi F and Picano E (2017) Simple six-item clinical score improves risk prediction capability of stress echocardiography, Heart, 10.1136/heartjnl-2017-312122, 104:9, (760-766), Online publication date: 1-May-2018. Scali M, de Azevedo Bellagamba C, Ciampi Q, Simova I, de Castro e Silva Pretto J, Djordjevic-Dikic A, Dodi C, Cortigiani L, Zagatina A, Trambaiolo P, Torres M, Citro R, Colonna P, Paterni M and Picano E (2017) Stress echocardiography with smartphone: real-time remote reading for regional wall motion, The International Journal of Cardiovascular Imaging, 10.1007/s10554-017-1167-2, 33:11, (1731-1736), Online publication date: 1-Nov-2017. Picano E and Scali M (2017) The lung water cascade in heart failure, Echocardiography, 10.1111/echo.13657, 34:10, (1503-1507), Online publication date: 1-Oct-2017. Picano E, Ciampi Q, Citro R, D'Andrea A, Scali M, Cortigiani L, Olivotto I, Mori F, Galderisi M, Costantino M, Pratali L, Di Salvo G, Bossone E, Ferrara F, Gargani L, Rigo F, Gaibazzi N, Limongelli G, Pacileo G, Andreassi M, Pinamonti B, Massa L, Torres M, Miglioranza M, Daros C, de Castro e Silva Pretto J, Beleslin B, Djordjevic-Dikic A, Varga A, Palinkas A, Agoston G, Gregori D, Trambaiolo P, Severino S, Arystan A, Paterni M, Carpeggiani C and Colonna P (2017) Stress echo 2020: the international stress echo study in ischemic and non-ischemic heart disease, Cardiovascular Ultrasound, 10.1186/s12947-016-0092-1, 15:1, Online publication date: 1-Dec-2017. (2016) Contrast Echocardiography ASE's Comprehensive Echocardiography, 10.1016/B978-0-323-26011-4.09944-7, (91-111), . (2016) Stress Echocardiography ASE's Comprehensive Echocardiography, 10.1016/B978-0-323-26011-4.09967-8, (237-283), . Marwick T and Picano E (2015) New Ultrasound Technologies for Quantitative Assessment of Left Ventricular Function Stress Echocardiography, 10.1007/978-3-319-20958-6_23, (377-399), . Pellikka P and Picano E (2015) Stress Echocardiography: A Historical Perspective Stress Echocardiography, 10.1007/978-3-319-20958-6_1, (3-18), . Peris V and Picano E (2015) Symptoms and Signs of Myocardial Ischemia Stress Echocardiography, 10.1007/978-3-319-20958-6_3, (37-51), . Cusmà-Piccione M, Zito C, Oreto L, D'Angelo M, Tripepi S, Di Bella G, Todaro M, Oreto G, Khandheria B and Carerj S (2015) Longitudinal Strain by Automated Function Imaging Detects Single-Vessel Coronary Artery Disease in Patients Undergoing Dipyridamole Stress Echocardiography, Journal of the American Society of Echocardiography, 10.1016/j.echo.2015.06.001, 28:10, (1214-1221), Online publication date: 1-Oct-2015. Picano E and Popescu B (2015) Technology and Training Requirements Stress Echocardiography, 10.1007/978-3-319-20958-6_10, (163-176), . Gaibazzi N and Picano E (2015) Echocardiographic Signs of Ischemia Stress Echocardiography, 10.1007/978-3-319-20958-6_6, (87-103), . Ostojic M, Picano E and Arandjelovic A (2015) Pathogenetic Mechanisms of Stress Stress Echocardiography, 10.1007/978-3-319-20958-6_5, (69-86), . Rigo F and Picano E (2015) Coronary Flow Reserve Stress Echocardiography, 10.1007/978-3-319-20958-6_9, (141-161), . Takeuchi M (2014) Current status of stress echocardiography: is it a required procedure for every sonographer?, Journal of Echocardiography, 10.1007/s12574-014-0226-0, 12:4, (129-137), Online publication date: 1-Dec-2014. Bombardini T, Arpesella G, Maccherini M, Procaccio F, Potena L, Bernazzali S, Leone O and Picano E (2014) Medium-term outcome of recipients of marginal donor hearts selected with new stress-echocardiographic techniques over standard criteria, Cardiovascular Ultrasound, 10.1186/1476-7120-12-20, 12:1, Online publication date: 1-Dec-2014. Picano E and Pellikka P (2013) Stress echo applications beyond coronary artery disease, European Heart Journal, 10.1093/eurheartj/eht350, 35:16, (1033-1040), Online publication date: 2-Apr-2014. Bombardini T, Gherardi S, Marraccini P, Schlueter M, Sicari R and Picano E (2013) The incremental diagnostic value of coronary flow reserve and left ventricular elastance during high-dose dipyridamole stress echocardiography in patients with normal wall motion at rest, International Journal of Cardiology, 10.1016/j.ijcard.2013.03.076, 168:2, (1683-1684), Online publication date: 1-Sep-2013. Weyman A (2013) More May Not Always Be Better, JACC: Cardiovascular Imaging, 10.1016/j.jcmg.2012.10.008, 6:1, (13-15), Online publication date: 1-Jan-2013. Bombardini T, Gherardi S, Leone O, Sicari R and Picano E (2013) Transplant of stunned donor hearts rescued by pharmacological stress echocardiography: a "proof of concept" report, Cardiovascular Ultrasound, 10.1186/1476-7120-11-27, 11:1, Online publication date: 1-Dec-2013. Kawata T, Daimon M, Hasegawa R, Toyoda T, Sekine T, Himi T, Uchida D, Miyazaki S, Hirose K, Ichikawa R, Maruyama M, Suzuki H and Daida H (2013) Prognostic value of coronary flow reserve assessed by transthoracic Doppler echocardiography on long-term outcome in asymptomatic patients with type 2 diabetes without overt coronary artery disease, Cardiovascular Diabetology, 10.1186/1475-2840-12-121, 12:1, (121), . Cotrim C, João I, Fazendas P, Almeida A, Lopes L, Stuart B, Cruz I, Caldeira D, Loureiro M, Morgado G and Pereira H (2013) Clinical applications of exercise stress echocardiography in the treadmill with upright evaluation during and after exercise, Cardiovascular Ultrasound, 10.1186/1476-7120-11-26, 11:1, Online publication date: 1-Dec-2013. Rigo F, Cortigiani L, Grolla E and Picano E (2012) Rest and Stress Echocardiography Clinical Applications of Cardiac CT, 10.1007/978-88-470-2522-6_33, (325-348), . Takagi A, Furugen A, Arai K, Gunji K, Hoshi H, Yagishita Y, Suzuki F, Ashihara K and Hagiwara N (2012) Time-dependent variation in coronary flow velocity reserve induced by adenosine triphosphate: comparison to low-dose dipyridamole, Journal of Echocardiography, 10.1007/s12574-012-0108-2, 10:1, (15-20), Online publication date: 1-Mar-2012. Picano E and Sicari R (2012) Stress Echocardiography Clinical Echocardiography, 10.1007/978-1-84882-521-5_8, (149-165), . Feng S, Jiang J, Hu P, Zhang J, Liu T, Zhao Q and Li B (2012) A phase I study on pharmacokinetics and pharmacodynamics of higenamine in healthy Chinese subjects, Acta Pharmacologica Sinica, 10.1038/aps.2012.114, 33:11, (1353-1358), Online publication date: 1-Nov-2012. Henein M, Sheppard M, Pepper J and Rigby M (2012) Coronary Artery Disease Clinical Echocardiography, 10.1007/978-1-84882-521-5_7, (115-147), . Grimaldi A, Olivotto I, Figini F, Pappalardo F, Capritti E, Ammirati E, Maisano F, Benussi S, Fumero A, Castiglioni A, De Bonis M, Vermi A, Colombo A, Zangrillo A and Alfieri O (2011) Dynamic assessment of 'valvular reserve capacity' in patients with rheumatic mitral stenosis, European Heart Journal - Cardiovascular Imaging, 10.1093/ejechocard/jer269, 13:6, (476-482), Online publication date: 1-Jun-2012. Picano E (2010) Basic Principles of Stress Echocardiography Stress Echocardiography, 10.3109/9781841847146-2, (1-11), Online publication date: 13-May-2010. Cotrim C, Almeida A, Miranda R, Almeida A, Cotrim H, Picano E and Carrageta M (2010) Stress-Induced Intraventricular Gradients in Symptomatic Athletes During Upright Exercise Continuous Wave Doppler Echocardiography, The American Journal of Cardiology, 10.1016/j.amjcard.2010.07.053, 106:12, (1808-1812), Online publication date: 1-Dec-2010. Franchi D, Cini D, Arpesella G, Gherardi S, Calamai I, Barletta G, Valente S, Pasanisi E, Sansoni S, Ricci C, Serra W, Picano E and Bombardini T (2010) Second-opinion stress tele-echocardiography for the Adonhers (Aged donor heart rescue by stress echo) project, Cardiovascular Ultrasound, 10.1186/1476-7120-8-20, 8:1, Online publication date: 1-Dec-2010. Ciampi Q, Pratali L, Citro R, Villari B, Picano E and Sicari R (2010) Clinical and prognostic role of pressure-volume relationship in the identification of responders to cardiac resynchronization therapy, American Heart Journal, 10.1016/j.ahj.2010.07.019, 160:5, (906-914), Online publication date: 1-Nov-2010. Ciampi Q, Pratali L, Bombardini T, Della Porta M, Petruzziello B, Villari B, Picano E and Sicari R (2010) Pressure-Volume Relationship During Dobutamine Stress Echocardiography Predicts Exercise Tolerance in Patients with Congestive Heart Failure, Journal of the American Society of Echocardiography, 10.1016/j.echo.2009.11.001, 23:1, (71-78), Online publication date: 1-Jan-2010. Picano E (2010) Stress and Stressors Stress Echocardiography, 10.3109/9781841847146-3, (12-19), Online publication date: 13-May-2010. Picano E (2009) Echocardiographic Signs of Ischemia Stress Echocardiography, 10.1007/978-3-540-76466-3_6, (75-89), . Picano E, Pibarot P, Lancellotti P, Monin J and Bonow R (2009) The Emerging Role of Exercise Testing and Stress Echocardiography in Valvular Heart Disease Stress Echocardiography, 10.1007/978-3-540-76466-3_36, (499-521), . Galderisi M and Picano E (2009) Diastolic Stress Echocardiography Stress Echocardiography, 10.1007/978-3-540-76466-3_25, (361-373), . Picano E (2009) Symptoms and Signs of Myocardial Ischemia Stress Echocardiography, 10.1007/978-3-540-76466-3_3, (31-42), . Rigo F, Lowenstein J and Picano E (2009) Coronary Flow Reserve Stress Echocardiography, 10.1007/978-3-540-76466-3_9, (125-144), . Picano E (2009) Stress Echocardiography: A Historical and Societal Perspective Stress Echocardiography, 10.1007/978-3-540-76466-3_1, (3-18), . Picano E and Schwitter J (2009) Stress Echocardiography Versus Stress CMR Stress Echocardiography, 10.1007/978-3-540-76466-3_40, (569-583), . Picano E, Pibarot P, Lancellotti P, Monin J and Bonow R (2009) The Emerging Role of Exercise Testing and Stress Echocardiography in Valvular Heart Disease, Journal of the American College of Cardiology, 10.1016/j.jacc.2009.07.046, 54:24, (2251-2260), Online publication date: 1-Dec-2009. Picano E (2009) Technology and Training Requirements Stress Echocardiography, 10.1007/978-3-540-76466-3_10, (145-155), . Picano E (2009) Stress Echo in Valvular Heart Disease Valvular Heart Disease in Clinical Practice, 10.1007/978-1-84800-275-3_5, (221-240), . Monaghan M and Picano E (2009) Contrast Stress Echocardiography Stress Echocardiography, 10.1007/978-3-540-76466-3_24, (343-359), . Dini F, Ghiadoni L, Conti U, Stea F, Buralli S, Taddei S and De Tommasi S (2009) Coronary Flow Reserve in Idiopathic Dilated Cardiomyopathy: Relation with Left Ventricular Wall Stress, Natriuretic Peptides, and Endothelial Dysfunction, Journal of the American Society of Echocardiography, 10.1016/j.echo.2009.01.013, 22:4, (354-360), Online publication date: 1-Apr-2009. Bombardini T, Galderisi M, Agricola E, Coppola V, Mottola G and Picano E (2008) Negative stress echo: Further prognostic stratification with assessment of pressure–volume relation, International Journal of Cardiology, 10.1016/j.ijcard.2006.12.093, 126:2, (258-267), Online publication date: 1-May-2008. Picano E, Molinaro S and Pasanisi E (2008) The diagnostic accuracy of pharmacological stress echocardiography for the assessment of coronary artery disease: a meta-analysis, Cardiovascular Ultrasound, 10.1186/1476-7120-6-30, 6:1, Online publication date: 1-Jun-2008. TSUKIJI M and WATANABE N (2008) Assessment of ischemic heart disease by transthoracic echocardiography, Choonpa Igaku, 10.3179/jjmu.35.613, 35:6, (613-622), . Bombardini T, Gemignani V, Bianchini E, Venneri L, Petersen C, Pasanisi E, Pratali L, Alonso-Rodriguez D, Pianelli M, Faita F, Giannoni M, Arpesella G and Picano E (2008) Diastolic time – frequency relation in the stress echo lab: filling timing and flow at different heart rates, Cardiovascular Ultrasound, 10.1186/1476-7120-6-15, 6:1, Online publication date: 1-Apr-2008. BORDACHAR P, LABROUSSE L, PLOUX S, THAMBO J, LAFITTE S, REANT P, JAIS P, HAISSAGUERRE M, CLEMENTY J and SANTOS P (2008) Validation of a New Noninvasive Device for the Monitoring of Peak Endocardial Acceleration in Pigs: Implications for Optimization of Pacing Site and Configuration, Journal of Cardiovascular Electrophysiology, 10.1111/j.1540-8167.2008.01105.x, 19:7, (725-729), Online publication date: 1-Jul-2008. Ciampi Q and Villari B (2007) Role of echocardiography in diagnosis and risk stratification in heart failure with left ventricular systolic dysfunction, Cardiovascular Ultrasound, 10.1186/1476-7120-5-34, 5:1, Online publication date: 1-Dec-2007. Bombardini T, Gemignani V, Bianchini E, Venneri L, Petersen C, Pasanisi E, Pratali L, Pianelli M, Faita F, Giannoni M and Picano E (2007) Cardiac reflections and natural vibrations: Force-frequency relation recording system in the stress echo lab, Cardiovascular Ultrasound, 10.1186/1476-7120-5-42, 5:1, Online publication date: 1-Dec-2007. Magagnin V, Delfino L, Cerutti S, Turiel M and Caiani E (2007) Nearly automated analysis of coronary Doppler flow velocity from transthoracic ultrasound images: validation with manual tracings, Medical & Biological Engineering & Computing, 10.1007/s11517-007-0178-x, 45:5, (483-493), Online publication date: 1-May-2007. MARWICK T (2007) Stress Echocardiography with Nonexercise Techniques: Principles, Protocols, Interpretation, and Clinical Applications The Practice of Clinical Echocardiography, 10.1016/B978-1-4160-3640-1.50020-4, (353-392), . Sicari R, Pingitore A, Aquaro G, Pasanisi E, Lombardi M and Picano E (2007) Cardiac functional stress imaging: A sequential approach with stress echo and cardiovascular magnetic resonance, Cardiovascular Ultrasound, 10.1186/1476-7120-5-47, 5:1, Online publication date: 1-Dec-2007. Baroncini L (2007) Short-term Risk Stratification with Accelerated High-dose Dipyridamole Stress Echocardiography: Follow-up into 301 Consecutive Outpatients, Journal of the American Society of Echocardiography, 10.1016/j.echo.2006.09.010, 20:3, (253-256), Online publication date: 1-Mar-2007. Jagathesan R, Rosen S, Foale R, Camici P and Picano E (2006) Effects of Long-Term Oral Dipyridamole Treatment on Coronary Microcirculatory Function in Patients With Chronic Stable Angina: A Substudy of the Persantine In Stable Angina (PISA) Study, Journal of Cardiovascular Pharmacology, 10.1097/01.fjc.0000245404.20922.9f, 48:3, (110-116), Online publication date: 1-Sep-2006. Habis M, Lardoux H, Verdaguer M, Hadjiat F, Chaib A, Jacq L, Caussin C, Pezzano M, Ghostine S, Hassan A and Lancelin B (2006) E´chocardiographie de stress, EMC - Cardiologie, 10.1016/S1166-4568(04)37880-0, 1:1, (1-7), Online publication date: 1-Jan-2006. Sicari R La coronaropatia Ecocardiografia clinica, 10.1007/88-470-0460-8_8, (117-144) Rigo F, Cortigiani L, Pasanisi E, Richieri M, Cutaia V, Celestre M, Raviele A and Picano E (2006) The additional prognostic value of coronary flow reserve on left anterior descending artery in patients with negative stress echo by wall motion criteria. A Transthoracic Vasodilator Stress Echocardiography Study, American Heart Journal, 10.1016/j.ahj.2005.03.008, 151:1, (124-130), Online publication date: 1-Jan-2006. Camarozano A, Siqueira-Filho A, Weitzel L, Resende P and Noé R (2006) The effects of early administration of atropine during dobutamine stress echocardiography: advantages and disadvantages of early dobutamine-atropine protocol, Cardiovascular Ultrasound, 10.1186/1476-7120-4-17, 4:1, Online publication date: 1-Mar-2006. Sicari R (2005) Relevance of tissue Doppler in the quantification of stress echocardiography for the detection of myocardial ischemia in clinical practice, Cardiovascular Ultrasound, 10.1186/1476-7120-3-2, 3:1, Online publication date: 1-Dec-2005. Bedetti G, Pasanisi E, Tintori G, Fonseca L, Tresoldi S, Minneci C, Jambrik Z, Ghelarducci B, Orlandini A and Picano E (2005) Stress echo in chest pain unit: the SPEED trial, International Journal of Cardiology, 10.1016/j.ijcard.2004.05.058, 102:3, (461-467), Online publication date: 1-Jul-2005. Khan I, Otero F, Font-Cordoba J, McCulloch M, Sheahan R, Parmar R and Defilippi C (2005) Adjunctive handgrip during dobutamine stress echocardiography: Invasive assessment of myocardial oxygen consumption in humans, Clinical Cardiology, 10.1002/clc.4960280709, 28:7, (349-352), Online publication date: 1-Jul-2005. Gligorova S and Agrusta M (2005) Pacing stress echocardiography, Cardiovascular Ultrasound, 10.1186/1476-7120-3-36, 3:1, Online publication date: 1-Dec-2005. Bombardini T (2005) Myocardial contractility in the echo lab: molecular, cellular and pathophysiological basis, Cardiovascular Ultrasound, 10.1186/1476-7120-3-27, 3:1, Online publication date: 1-Dec-2005. Picano E (2005) Stress echocardiography: the long and winding road from meta-analysis to bedside, The International Journal of Cardiovascular Imaging, 10.1007/s10554-004-6923-4, 21:2-3, (209-211), Online publication date: 1-Apr-2005. Bombardini T, Agrusta M, Natsvlishvili N, Solimene F, Pap R, Coltorti F, Varga A, Mottola G and Picano E (2005) Noninvasive assessment of left ventricular contractility by pacemaker stress echocardiography, European Journal of Heart Failure, 10.1016/j.ejheart.2004.04.019, 7:2, (173-181), Online publication date: 1-Mar-2005. Paelinck B, Lamb H, Bax J, van der Wall E and de Roos A (2004) MR flow mapping of dobutamine-induced changes in diastolic heart function, Journal of Magnetic Resonance Imaging, 10.1002/jmri.10448, 19:2, (176-181), Online publication date: 1-Feb-2004. Picano E (2014) Stress echocardiography, Expert Review of Cardiovascular Therapy, 10.1586/14779072.2.1.77, 2:1, (77-88), Online publication date: 1-Jan-2004. Habis M, Lardoux H, Verdaguer M, Hadjiat F, Chaib A, Jacq L, Caussin C, Pezzano M, Ghostine S, Hassan A and Lancelin B (2004) Échocardiographie de stress, EMC - Cardiologie-Angéiologie, 10.1016/j.emcaa.2003.11.001, 1:1, (38-48), Online publication date: 1-Feb-2004. Agricola E, Oppizzi M, Pisani M and Margonato A (2004) Stress echocardiography in heart failure, Cardiovascular Ultrasound, 10.1186/1476-7120-2-11, 2:1, Online publication date: 1-Jul-2004. YOSHIKAWA K, SHIOGAI T, KASAI T, TAKAYAS N, NAKAGAWA M, ANDOU M and SHIMIZU Y (2004) , Neurosonology, 10.2301/neurosonology.17.68, 17:2, (68-71), . Henein M, Sheppard M, Pepper J and Rigby M (2004) Coronary Artery Disease Clinical Echocardiography, 10.1007/978-1-4471-3785-6_8, (119-148), . Picano E (2003) Symptoms and Signs of Myocardial Ischemia Stress Echocardiography, 10.1007/978-3-662-05096-5_3, (27-36), . Picano E (2003) Stress echocardiography: a historical perspective, The American Journal of Medicine, 10.1016/S0002-9343(02)01427-4, 114:2, (126-130), Online publication date: 1-Feb-2003. Sicari R, Pasanisi E, Venneri L, Landi P, Cortigiani L and Picano E (2003) Stress echo results predict mortality: a large-scale multicenter prospective international study, Journal of the American College of Cardiology, 10.1016/S0735-1097(02)02863-2, 41:4, (589-595), Online publication date: 1-Feb-2003. Bombardini T, Correia M, Cicerone C, Agricola E, Ripoli A and Picano E (2003) Force-frequency relationship in the echocardiography laboratory: a noninvasive assessment of Bowditch Treppe?, Journal of the American Society of Echocardiography, 10.1016/S0894-7317(03)00221-9, 16:6, (646-655), Online publication date: 1-Jun-2003. Rigo F, Richieri M, Pasanisi E, Cutaia V, Zanella C, Della Valentina P, Di Pede F, Raviele A and Picano E (2003) Usefulness of coronary flow reserve over regional wall motion when added to dual-imaging dipyridamole echocardiography, The American Journal of Cardiology, 10.1016/S0002-9149(02)03153-3, 91:3, (269-273), Online publication date: 1-Feb-2003. Picano E, Rigo F and Lowenstein J (2003) Coronary Flow Reserve Stress Echocardiography, 10.1007/978-3-662-05096-5_37, (437-453), . Laghi-Pasini F, Guideri F, Petersen C, Lazzerini P, Sicari R, Capecchi P and Picano E (2003) Blunted increase in plasma adenosine levels following dipyridamole stress in dilated cardiomyopathy patients, Journal of Internal Medicine, 10.1111/j.1365-2796.2003.01234.x, 254:6, (591-596), Online publication date: 1-Dec-2003. Lowenstein J, Tiano C, Marquez G, Presti C and Quiroz C (2003) Simultaneous analysis of wall motion and coronary flow reserve of the left anterior descending coronary artery by transthoracic doppler echocardiography during dipyridamole stress echocardiography, Journal of the American Society of Echocardiography, 10.1016/S0894-7317(03)00281-5, 16:6, (607-613), Online publication date: 1-Jun-2003. Picano E, Alaimo A, Chubuchny V, Plonska E, Baldo V, Baldini U, Pauletti M, Perticucci R, Fonseca L, Villarraga H, Emanuelli C, Miracapillo G, Hoffmann E and De Nes M (2002) Noninvasive pacemaker stress echocardiography for diagnosis of coronary artery disease, Journal of the American College of Cardiology, 10.1016/S0735-1097(02)02157-5, 40:7, (1305-1310), Online publication date: 1-Oct-2002. Picano E (2002) Dipyridamole in myocardial ischemia: Good Samaritan or Terminator?, International Journal of Cardiology, 10.1016/S0167-5273(02)00060-8, 83:3, (215-216), Online publication date: 1-Jun-2002. Imran M, Pálinkás A, Pasanisi E, De Nes M and Picano E (2002) Optimal reading criteria in stress echocardiography, The American Journal of Cardiology, 10.1016/S0002-9149(02)02510-9, 90:4, (444-445), Online publication date: 1-Aug-2002. Kondo I, Mizushige K, Nozaki S, Iwado Y, Hirao K, Senda S, Kohno M and Matsuo H (2001) Ultrasonic tissue characterization can predict β-blocker efficacy in dilated cardiomyopathy, Ultrasound in Medicine & Biology, 10.1016/S0301-5629(01)00417-3, 27:8, (1079-1086), Online publication date: 1-Aug-2001. Picano E, Pálinkás A and Amyot R (2001) Diagnosis of myocardial ischemia in hypertensive patients, Journal of Hypertension, 10.1097/00004872-200107000-00001, 19:7, (1177-1183), Online publication date: 1-Jul-2001. Pálinkás A, Picano E, Rodriguez O, Diordjevic-Dikic A, Landi P, Varga A and Ghelarducci B (2001) Safety of ergot stress echocardiography for non-invasive detection of coronary vasospasm, Coronary Artery Disease, 10.1097/00019501-200112000-00008, 12:8, (649-654), Online publication date: 1-Dec-2001. Picano E and Abbracchio M (2000) Adenosine, the imperfect endogenous anti-ischemic cardio-neuroprotector, Brain Research Bulletin, 10.1016/S0361-9230(00)00249-5, 52:2, (75-82), Online publication date: 1-May-2000. Song J, Park S, Kang D, Hong M, Kim J, Lee C and Park S (2000) Safety and clinical impact of ergonovine stress echocardiography for diagnosis of coronary vasospasm, Journal of the American College of Cardiology, 10.1016/S0735-1097(00)00646-X, 35:7, (1850-1856), Online publication date: 1-Jun-2000. POLDERMANS D, BAX J, THOMSON I, BOERSMA E, MEER P, FIORETTI P, ELHENDY A, VEN L, ROELANDT J and URK H (2000) Role of Dobutamine Stress Echocardiography for Preoperative Cardiac Risk Assessment Before Major Vascular Surgery: A Diagnostic Tool Comes of Age, Echocardiography, 10.1111/j.1540-8175.2000.tb00998.x, 17:1, (79-91), Online publication date: 1-Jan-2000. Tanaka M, Hashimoto Y and Numano F (2000) Decreased Left Ventricular Contractility Reserve In Patients With Never-Treated Essential Hypertension, Clinical and Experimental Pharmacology and Physiology, 10.1046/j.1440-1681.2000.03351.x, 27:11, (871-875), Online publication date: 12-Nov-2000. Tommasi S, Carluccio E, Bentivoglio M, Corea L and Picano E (2000) Low-dose dipyridamole infusion acutely increases exercise capacity in angina pectoris, Journal of the American College of Cardiology, 10.1016/S0735-1097(99)00534-3, 35:1, (83-88), Online publication date: 1-Jan-2000. Picano E and Trivieri M (1999) Pharmacologic stress echocardiography in the assessment of coronary artery disease, Current Opinion in Cardiology, 10.1097/00001573-199911000-00003, 14:6, (464), Online publication date: 1-Nov-1999. Gaddi O, Tortorella G, Picano E, Pantaleoni M, Manicardi E, Varga A, Moneta I and Guiducci U (1999) Diagnostic and prognostic value of vasodilator stress echocardiography in asymptomatic Type 2 diabetic patients with positive exercise thallium scintigraphy: a pilot study, Diabetic Medicine, 10.1046/j.1464-5491.1999.00145.x, 16:9, (762-766), Online publication date: 1-Sep-1999. Beleslin B, Ostojic M, Djordjevic-Dikic A, Babic R, Nedeljkovic M, Stankovic G, Stojkovic S, Marinkovic J, Nedeljkovic I, Stepanovic J, Saponjski J, Petrasinovic Z, Nedeljkovic S and Kanjuh V (1999) Integrated evaluation of relation between coronary lesion features and stress echocardiography results: the importance of coronary lesion morphology, Journal of the American College of Cardiology, 10.1016/S0735-1097(98)00613-5, 33:3, (717-726), Online publication date: 1-Mar-1999. Miyamoto M, Rose G, Weissman N, Guerrero J, Semigran M and Picard M (1999) Abnormal Global Left Ventricular Relaxation Occurs Early During the Development of Pharmacologically Induced Ischemia, Journal of the American Society of Echocardiography, 10.1016/S0894-7317(99)70123-9, 12:2, (113-120), Online publication date: 1-Feb-1999. MARWICK T (1999) Advances in Exercise Echocardiography., Echocardiography, 10.1111/j.1540-8175.1999.tb00140.x, 16:8, (841-856), Online publication date: 1-Nov-1999. Orsinelli D and Daniels C (1999) PHARMACOLOGIC STRESS ECHOCARDIOGRAPHY, Cardi