Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2043357528', 'doi': 'https://doi.org/10.1080/10286020.2011.599321', 'title': 'Identification of the metabolites of baicalein in human plasma', 'display_name': 'Identification of the metabolites of baicalein in human plasma', 'publication_year': 2011, 'publication_date': '2011-09-01', 'ids': {'openalex': 'https://openalex.org/W2043357528', 'doi': 'https://doi.org/10.1080/10286020.2011.599321', 'mag': '2043357528', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21830892'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/10286020.2011.599321', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S201142877', 'display_name': 'Journal of Asian Natural Products Research', 'issn_l': '1028-6020', 'issn': ['1028-6020', '1477-2213'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101922611', 'display_name': 'Xiaoyu Guo', 'orcid': 'https://orcid.org/0000-0003-2622-6676'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao-Yu Guo', 'raw_affiliation_strings': ['Department of Natural Medicines,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China)'], 'affiliations': [{'raw_affiliation_string': 'Department of Natural Medicines,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China)', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007288360', 'display_name': 'Lin Yang', 'orcid': 'https://orcid.org/0000-0002-4130-4188'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lin Yang', 'raw_affiliation_strings': ['Department of Natural Medicines , School of Pharmaceutical Sciences, Peking University , Beijing, 100191, China ; Center of Cardiovascular Diseases , Xiyuan Hospital, China Academy of Chinese Medical Sciences , Beijing, 100091, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Natural Medicines , School of Pharmaceutical Sciences, Peking University , Beijing, 100191, China ; Center of Cardiovascular Diseases , Xiyuan Hospital, China Academy of Chinese Medical Sciences , Beijing, 100091, China', 'institution_ids': ['https://openalex.org/I20231570', 'https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100383066', 'display_name': 'Ying Chen', 'orcid': 'https://orcid.org/0000-0002-5642-1272'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Ying Chen', 'raw_affiliation_strings': ['Department of Natural Medicines,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China)'], 'affiliations': [{'raw_affiliation_string': 'Department of Natural Medicines,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China)', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079115391', 'display_name': 'Qifang Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I103890011', 'display_name': 'Shenyang Pharmaceutical University', 'ror': 'https://ror.org/03dnytd23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I103890011']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qi-Fang Wang', 'raw_affiliation_strings': ['Shenyang Pharmaceutical University,Shenyang 110016,China)'], 'affiliations': [{'raw_affiliation_string': 'Shenyang Pharmaceutical University,Shenyang 110016,China)', 'institution_ids': ['https://openalex.org/I103890011']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102427974', 'display_name': 'Qinghui Sun', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I103890011', 'display_name': 'Shenyang Pharmaceutical University', 'ror': 'https://ror.org/03dnytd23', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I103890011']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qi-Shi Sun', 'raw_affiliation_strings': ['Shenyang Pharmaceutical University,Shenyang 110016,China)'], 'affiliations': [{'raw_affiliation_string': 'Shenyang Pharmaceutical University,Shenyang 110016,China)', 'institution_ids': ['https://openalex.org/I103890011']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028708130', 'display_name': 'Yi-Xin Che', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yi-Xin Che', 'raw_affiliation_strings': ['Department of Natural Medicines,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China)'], 'affiliations': [{'raw_affiliation_string': 'Department of Natural Medicines,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China)', 'institution_ids': ['https://openalex.org/I20231570']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5068951119', 'display_name': 'Qing‐Ming Che', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qing-Ming Che', 'raw_affiliation_strings': ['Department of Natural Medicines,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China)'], 'affiliations': [{'raw_affiliation_string': 'Department of Natural Medicines,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China)', 'institution_ids': ['https://openalex.org/I20231570']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.917, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 20, 'citation_normalized_percentile': {'value': 0.872125, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '13', 'issue': '9', 'first_page': '861', 'last_page': '868'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12582', 'display_name': 'Therapeutic Potential of Flavonoids in Medicine', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12582', 'display_name': 'Therapeutic Potential of Flavonoids in Medicine', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11613', 'display_name': 'Medicinal Plants: Chemical Constituents and Biological Activities', 'score': 0.9947, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11385', 'display_name': 'Biological Activities of Triterpenoids and Saponins', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/baicalein', 'display_name': 'Baicalein', 'score': 0.9987887}, {'id': 'https://openalex.org/keywords/flavones', 'display_name': 'Flavones', 'score': 0.6749782}, {'id': 'https://openalex.org/keywords/glucuronide', 'display_name': 'Glucuronide', 'score': 0.62437004}, {'id': 'https://openalex.org/keywords/baicalin', 'display_name': 'Baicalin', 'score': 0.5577827}, {'id': 'https://openalex.org/keywords/scutellaria-baicalensis', 'display_name': 'Scutellaria baicalensis', 'score': 0.468258}, {'id': 'https://openalex.org/keywords/scutellaria', 'display_name': 'Scutellaria', 'score': 0.4472955}, {'id': 'https://openalex.org/keywords/biotransformation', 'display_name': 'Biotransformation', 'score': 0.43765756}, {'id': 'https://openalex.org/keywords/metabolic-pathway', 'display_name': 'Metabolic pathway', 'score': 0.41374293}], 'concepts': [{'id': 'https://openalex.org/C2781466915', 'wikidata': 'https://www.wikidata.org/wiki/Q2879363', 'display_name': 'Baicalein', 'level': 2, 'score': 0.9987887}, {'id': 'https://openalex.org/C2778153525', 'wikidata': 'https://www.wikidata.org/wiki/Q803769', 'display_name': 'Scutellaria baicalensis', 'level': 4, 'score': 0.7482982}, {'id': 'https://openalex.org/C2777477808', 'wikidata': 'https://www.wikidata.org/wiki/Q407595', 'display_name': 'Metabolite', 'level': 2, 'score': 0.7463145}, {'id': 'https://openalex.org/C2776292868', 'wikidata': 'https://www.wikidata.org/wiki/Q424525', 'display_name': 'Flavones', 'level': 2, 'score': 0.6749782}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.64727646}, {'id': 'https://openalex.org/C2779186261', 'wikidata': 'https://www.wikidata.org/wiki/Q137786', 'display_name': 'Glucuronide', 'level': 3, 'score': 0.62437004}, {'id': 'https://openalex.org/C2780113650', 'wikidata': 'https://www.wikidata.org/wiki/Q2879368', 'display_name': 'Baicalin', 'level': 3, 'score': 0.5577827}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.5001855}, {'id': 'https://openalex.org/C3020134792', 'wikidata': 'https://www.wikidata.org/wiki/Q79749', 'display_name': 'Human plasma', 'level': 2, 'score': 0.48776966}, {'id': 'https://openalex.org/C2775897108', 'wikidata': 'https://www.wikidata.org/wiki/Q156764', 'display_name': 'Scutellaria', 'level': 4, 'score': 0.4472955}, {'id': 'https://openalex.org/C27881333', 'wikidata': 'https://www.wikidata.org/wiki/Q864895', 'display_name': 'Biotransformation', 'level': 3, 'score': 0.43765756}, {'id': 'https://openalex.org/C179998833', 'wikidata': 'https://www.wikidata.org/wiki/Q381233', 'display_name': 'High-performance liquid chromatography', 'level': 2, 'score': 0.42027962}, {'id': 'https://openalex.org/C192989942', 'wikidata': 'https://www.wikidata.org/wiki/Q68685', 'display_name': 'Metabolic pathway', 'level': 3, 'score': 0.41374293}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.3732148}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.24844122}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.19847}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.19596255}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.16155264}, {'id': 'https://openalex.org/C188947578', 'wikidata': 'https://www.wikidata.org/wiki/Q200253', 'display_name': 'Traditional Chinese medicine', 'level': 3, 'score': 0.13134605}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.09884572}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D044950', 'descriptor_name': 'Flavanones', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': True}, {'descriptor_ui': 'D020719', 'descriptor_name': 'Glucuronides', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': True}, {'descriptor_ui': 'D031364', 'descriptor_name': 'Scutellaria baicalensis', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D002851', 'descriptor_name': 'Chromatography, High Pressure Liquid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044950', 'descriptor_name': 'Flavanones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044950', 'descriptor_name': 'Flavanones', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D044950', 'descriptor_name': 'Flavanones', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D044950', 'descriptor_name': 'Flavanones', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D044950', 'descriptor_name': 'Flavanones', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D020719', 'descriptor_name': 'Glucuronides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020719', 'descriptor_name': 'Glucuronides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D020719', 'descriptor_name': 'Glucuronides', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D031364', 'descriptor_name': 'Scutellaria baicalensis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/10286020.2011.599321', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S201142877', 'display_name': 'Journal of Asian Natural Products Research', 'issn_l': '1028-6020', 'issn': ['1028-6020', '1477-2213'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21830892', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 5, 'referenced_works': ['https://openalex.org/W1963528029', 'https://openalex.org/W1994924428', 'https://openalex.org/W2002750001', 'https://openalex.org/W2012702883', 'https://openalex.org/W2051238015'], 'related_works': ['https://openalex.org/W3196841018', 'https://openalex.org/W3116588626', 'https://openalex.org/W3010909540', 'https://openalex.org/W2429874541', 'https://openalex.org/W2383763915', 'https://openalex.org/W2355484294', 'https://openalex.org/W2293854843', 'https://openalex.org/W2008891304', 'https://openalex.org/W2003800993', 'https://openalex.org/W2000815058'], 'abstract_inverted_index': {'Abstract': [0], 'The': [1], 'metabolites': [2, 26], 'of': [3, 16, 64, 82, 87], 'baicalein': [4, 33, 65], 'in': [5, 21, 66], 'human': [6], 'plasma': [7], 'were': [8, 35], 'investigated': [9], 'after': [10], 'taking': [11], 'baicalein,': [12], 'which': [13], 'is': [14, 52], 'one': [15], 'the': [17, 30, 40, 58, 60, 80], 'main': [18], 'bioactive': [19], 'flavones': [20], 'Scutellaria': [22], 'baicalensis': [23], 'Georgi.': [24], 'Five': [25], '(M1–M5)': [27], 'together': [28], 'with': [29], 'parent': [31], 'drug': [32], '(P)': [34], 'detected': [36], 'and': [37, 44], 'identified': [38], 'by': [39, 79], 'HPLC-diode-array': [41], 'detector': [42], '(DAD)': [43], 'LC-MS/MS': [45], 'methods.': [46], 'Among': [47], 'them,': [48], '7-methoxybaicalein': [49], '6-O-glucuronide': [50], '(M5)': [51], 'a': [53], 'new': [54], 'metabolite.': [55], 'Based': [56], 'on': [57], 'results,': [59], 'proposed': [61], 'metabolic': [62], 'pathway': [63], 'humans': [67], 'was': [68, 76], 'inferred.': [69], 'Keywords:': [70], 'baicaleinflavonesmetaboliteshuman': [71], 'plasmaLC-MS/MSHPLC-DAD': [72], 'Acknowledgements': [73], 'This': [74], 'research': [75], 'financially': [77], 'supported': [78], 'program': [81], 'National': [83], 'Natural': [84], 'Science': [85], 'Foundation': [86], 'China': [88], '(Grant': [89], 'No.': [90], '30225049).': [91]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2043357528', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-08-15T06:42:42.630359', 'created_date': '2016-06-24'}