Presenilin/γ-Secretase-mediated Cleavage of the Voltage-gated Sodium Channel β2-Subunit Regulates Cell Adhesion and Migration

Name: Work Video:
Duration: 3 min 30 s
Doo Yeon Kim; Laura Ingano; Bryce W. Carey; Warren H. Pettingell; Dora M. Kovacs
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2860, 2867, 2871, 2875, 2897, 2991, 3040, 3051, 3055, 3066, 3072, 3081, 3085, 3128, 3247, 3253, 3337, 3464, 3469, 3558, 3561, 3597, 3613, 3617, 3634, 3826, 3889, 3894, 3905, 3915, 3925, 3943, 4058, 4067, 4151, 4154, 4171, 4174, 4227, 4260, 4294, 4298], 'IgCAM': [11, 279], 'superfamily': [12, 280, 1658], 'and': [13, 20, 88, 104, 160, 169, 252, 263, 281, 288, 356, 372, 428, 437, 520, 531, 547, 576, 686, 732, 737, 819, 940, 1083, 1106, 1327, 1438, 1464, 1581, 1602, 1614, 1625, 1645, 1694, 1750, 1755, 1901, 1917, 1925, 1993, 2028, 2058, 2109, 2129, 2143, 2166, 2198, 2263, 2289, 2319, 2325, 2336, 2359, 2471, 2477, 2512, 2533, 2540, 2555, 2674, 2706, 2739, 2752, 2774, 2782, 2841, 2866, 2896, 2972, 3023, 3078, 3093, 3110, 3184, 3587, 3624, 3636, 3702, 4062, 4206, 4264], 'serves': [14, 282], 'as': [15, 283, 1606, 1697, 1765, 1854, 2076, 2367, 2612, 2920, 3043, 3698, 3967], 'both': [16, 284, 1621, 1647, 3182], 'an': [17, 21, 48, 285, 289, 316, 1691, 2561, 3044, 3823, 4011], 'adhesion': [18, 159, 262, 286, 427, 530, 546, 624, 1112, 1265, 1272, 1329, 1383, 1661, 1700, 1900, 1916, 3593], 'molecule': [19, 287], 'auxiliary': [22, 290, 1607], 'subunit': [23, 291, 1580, 1938, 2257], 'channel.': [28, 296], 'Here': [29, 297, 1847], 'we': [30, 114, 145, 206, 298, 382, 413, 474, 1848, 3564, 3813, 4086, 4099, 4145, 4195], 'found': [31, 163, 299, 431, 3565, 4235], 'that': [32, 164, 246, 300, 432, 514, 846, 1323, 3068, 3075, 3249, 3835, 3864, 3951, 4131, 4148, 4165, 4185, 4218, 4236, 4293], 'β2': [33, 57, 123, 141, 247, 301, 325, 391, 409, 515, 1853, 1883, 1937, 2256, 2760, 3104, 3582, 3589, 3628, 3648, 3802, 3818, 3837, 3854, 3865, 3952, 4024, 4123, 4287, 4306], 'undergoes': [34, 302, 1876, 3866, 3953], 'ectodomain': [35, 54, 303, 322, 1867, 3176, 3707, 3868, 3901, 3955, 4017, 4082, 4138, 4179], 'shedding': [36, 304, 1542, 3708, 3869, 3902, 3956, 4018, 4083, 4180], 'followed': [37, 305, 2206, 3957], 'by': [38, 75, 143, 218, 234, 306, 343, 411, 486, 502, 568, 683, 699, 1441, 1553, 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3238, 3327, 3472, 3647, 3717, 3808, 3873, 3934, 3969, 4016, 4093, 4119, 4158, 4251, 4279], 'cleavage': [55, 64, 255, 323, 332, 523, 537, 697, 741, 1087, 1258, 1868, 1878, 1890, 2445, 3177, 3233, 3319, 3339, 3638, 3645, 3665, 3806, 3896, 3966, 4139], 'Chinese': [59, 179, 327, 447, 654], 'hamster': [60, 180, 328, 448, 655], 'ovary': [61, 181, 329, 449], 'cells.': [62, 92, 267, 330, 360, 535, 1905, 3048, 4095], 'Subsequent': [63, 331], 'remaining': [67, 335, 1872], '15-kDa': [68, 336, 1873, 3916, 3944, 4175, 4187, 4299], 'C-terminal': [69, 337, 636, 647, 740, 1946, 3827], 'fragment': [70, 338, 3885], '(β2-CTF)': [71, 339], 'was': [72, 128, 340, 396, 566, 1951, 1961, 1971, 2327, 2349, 2506, 2723, 2731, 2828, 2852, 2906, 3037, 3886, 4064, 4078, 4113, 4266], 'independently': [73, 341, 4210], 'inhibited': [74, 166, 342, 434], 'three': [76, 344, 2551, 2574, 2681, 2725, 2890], 'specific': [77, 152, 345, 420, 4219], 'γ-secretase': [78, 112, 116, 153, 253, 346, 380, 384, 421, 521, 856, 1094, 1565, 1889, 2316, 3318, 3930, 3959, 4166, 4203, 4222], 'inhibitors,': [79, 347, 4204], 'dominant': [83, 351, 4261], 'negative': [84, 352, 4262], 'form': [85, 353], 'PS1,': [87, 355, 614, 1992], 'PS1/PS2': [90, 358, 2022, 4280], 'knock-out': [91, 359, 1368, 2023, 4281], 'γ-Secretase': [93, 361, 802], 'inhibitor': [94, 362, 2201, 2341, 4035, 4069], 'also': [96, 186, 207, 230, 364, 454, 475, 498, 1370, 1751, 3330, 3649, 3803, 4234], 'increased': [97, 203, 365, 471, 3912, 4150, 4228, 4239, 4278], 'endogenous': [98, 366], 'β2-CTF': [99, 204, 257, 367, 472, 525, 1875, 2643, 2812, 4117, 4157, 4188, 4212, 4229, 4237, 4275, 4300], 'levels': [100, 224, 368, 492, 2015, 2215, 3913, 3941, 4118, 4152, 4213, 4230, 4238, 4276], 'neuroblastoma': [102, 190, 370, 458], 'cells': [103, 182, 191, 371, 450, 459, 1983, 2032, 2045, 2121, 2176, 2525, 2578, 2645, 2683, 2758, 2814, 2824, 2873, 2905, 2979, 3012, 3067, 3816, 3851, 4022, 4121, 4160, 4199, 4253, 4283], 'mouse': [105, 373, 2106], 'primary': [106, 374, 2069], 'neuronal': [107, 375, 1378, 2071, 4304], 'cultures.': [108, 376], 'In': [109, 377, 2353, 2443, 4142, 4303], 'cell-free': [111, 379], 'assay,': [113, 381], 'detected': [115, 383], 'activity-dependent': [117, 385, 3960], 'generation': [118, 386, 2362], '12': [121, 389, 2651, 2820], 'kDa': [122, 390, 3841, 4060, 4156], 'intracellular': [124, 392, 643, 651, 1884], 'domain': [125, 393, 1086, 1885], '(ICD),': [126, 394], 'which': [127, 395, 701, 3187, 3657, 3713], 'loosely': [129, 397], 'associated': [130, 398, 4310], 'with': [131, 178, 399, 446, 1073, 1753, 1984, 2012, 2053, 2141, 2440, 2528, 2553, 2560, 2576, 2581, 2585, 2638, 2648, 2663, 2702, 2766, 2772, 2817, 2911, 2948, 2955, 2967, 2982, 3003, 3089, 3123, 3196, 3819, 3888, 3936, 4027, 4200, 4240, 4256, 4285, 4311], 'membrane': [133, 401, 844, 1081, 2452, 2510], 'fraction.': [134, 402], 'To': [135, 403, 2495, 2641, 3799, 4008, 4073, 4183], 'assess': [136, 404, 3800, 4075], 'functional': [138, 406, 1910], 'role': [139, 407, 1118, 1911], 'processing': [142, 410, 663, 1920, 2346, 3923, 3961, 4296], 'γ-secretase,': [144, 412], 'tested': [146, 208, 414, 476, 4088], 'whether': [147, 209, 415, 477, 3801, 4010, 4076], 'N-[N-(3,5-difluorophenylacetyl-l-alanyl)]-S-phenylglycine': [148, 416], 't-butylester': [149, 417], '(DAPT),': [150, 418], 'inhibitor,': [154, 422, 3931], 'would': [155, 213, 423, 481], 'alter': [156, 424], 'β2-mediated': [157, 425], 'cell': [158, 216, 232, 426, 484, 500, 545, 623, 1111, 1264, 1325, 1328, 1379, 1382, 1626, 1660, 1915, 1976, 2025, 2169, 2721, 2915, 2952, 3016, 3031, 3061, 3592], 'migration.': [161, 429, 548, 3032], 'We': [162, 430, 1978, 3578, 4233], 'DAPT': [165, 185, 199, 433, 453, 467, 2318, 2470, 2649, 2673, 2693, 2787, 2818, 4052, 4149, 4244], 'cell-cell': [167, 261, 435, 529, 1699, 1899, 2607], 'aggregation': [168, 436, 2608], 'migration': [170, 188, 217, 233, 264, 438, 456, 485, 501, 532, 1326, 1380, 1902, 1918, 2066, 2916], 'wound': [173, 441, 2827, 2861, 2876, 2901], 'healing': [174, 442, 2850], 'assay': [175, 443, 2222], 'carried': [176, 444], 'out': [177, 445], 'expressing': [183, 451, 2759, 3817, 4023, 4122, 4259], 'β2.': [184, 452, 1870, 3577, 4141, 4162, 4182], 'reduced': [187, 455], 'modified': [194, 462], 'Boyden': [195, 463], 'chamber': [196, 464, 3042], 'assay.': [197, 465], 'Since': [198, 466], 'levels,': [205, 473], 'β2-CTFs': [210, 478, 4248], 'β2-ICDs': [212, 480], 'directly': [214, 482, 2174, 4087], 'affect': [215, 483], 'overexpressing': [219, 487, 4161], 'recombinant': [220, 488], 'proteins.': [221, 489], 'Interestingly,': [222, 490, 1092, 3642], 'elevated': [223, 491, 3939, 4211], 'β2-CTFs,': [226, 494, 1897], 'but': [227, 495, 3846], 'not': [228, 496], 'ICDs,': [229, 497], 'blocked': [231, 499, 2534, 4065], '81': [235, 503], 'to': [236, 504, 691, 727, 751, 753, 1089, 1434, 1550, 1568, 1618, 1643, 1655, 1690, 1879, 2002, 2060, 2311, 2508, 3028, 3039, 3064, 3080, 3206, 3336, 3468, 3580, 3585, 3596, 3633, 3662, 3709, 3810, 3848, 3855, 3871, 3875, 4115, 4215], '93%.': [237, 505], 'Together,': [238, 506], 'our': [239, 507, 4094], 'findings': [240, 508], 'show': [241, 509, 4292], 'for': [242, 260, 510, 528, 927, 1119, 1375, 1421, 1563, 1649, 1857, 1912, 1974, 2158, 2457, 2492, 2518, 2557, 2650, 2657, 2713, 2776, 2819, 2987, 3025, 3030, 3654, 4081, 4170, 4192, 4226], 'first': [244, 512], 'time': [245, 513, 2716, 2749], 'PS/γ-secretase': [250, 518, 924, 1120, 1376, 1546, 1858, 1913, 3117, 3125, 3207, 3456, 3695, 3922, 4193], 'substrate': [251, 519, 1566, 1856, 4191], 'mediated': [254, 522, 698, 1552, 1859], 'required': [259, 527, 926], 'β2-expressing': [266, 534], 'Presenilin/γ-secretase-mediated': [536], 'regulates': [544], 'Vol.': [549], '280': [550], '(2005)': [551], '23251-23261Journal': [552], 'Biological': [554], 'ChemistryVol.': [555], '280Issue': [556], '33PreviewPage': [557], '23251:': [558], 'grant': [560], 'footnote': [561], 'should': [562], 'read': [563], '"This': [564], 'work': [565], 'supported': [567], 'grants': [569], 'from': [570, 678, 1953, 2104, 2272, 2323, 2351, 2499, 4105, 4178], 'NIA/National': [572], 'Institutes': [573], 'Health': [575], 'John': [578], 'Douglas': [579], 'French': [580], "Alzheimer's": [581], 'Foundation."': [582], 'Full-Text': [583], 'PDF': [584, 834, 954, 1010, 1032, 1164, 1227, 1249, 1504, 1730, 1785, 1815, 1841, 2094, 2385, 2413, 2634, 2942, 3147, 3169, 3222, 3307, 3364, 3420, 3490, 3512, 3737, 3791, 4002], 'Open': [585], 'Access': [586], 'A': [587], 'major': [588], 'pathologic': [589], 'hallmark': [590], 'Alzheimer': [592, 756], 'disease': [593, 757], 'deposition': [596], 'amyloid': [598, 606], 'β-peptide': [599], '(Aβ)': [600], '1The': [601], 'abbreviations': [602], 'used': [603, 1973, 2001, 2244], 'are:': [604], 'Aβ,': [605], 'β-peptide;': [607], 'APP,': [608, 744, 923, 1100, 3699, 3849, 3872], 'β-amyloid': [609, 679], 'precursor': [610, 680], 'protein;': [611], 'PS,': [612], 'presenilin;': [613], '1;': [616], 'PS2,': [617], '2;': [619], 'TPA,': [620, 3937], '12-O-tetradecanoylphorbol-13-acetate;': [621], 'CAM,': [622], 'molecule;': [625], 'β2,': [626, 1892, 1985, 4020, 4085], 'β2-subunit;': [630], 'β2-CTF,': [631, 1986, 4061, 4176], 'fragment;': [637, 648], 'β2-ICD,': [638, 1987], 'domain;': [644, 652], 'NE-CTF,': [645, 1989], 'nectin-1': [646, 650, 1644, 3586], 'NE-ICD,': [649, 1990], 'CHO,': [653], 'ovary;': [656], 'BisTris,': [657], '2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol;': [658], 'TAPI-1,': [659, 4030], 'tumor': [660], 'necrosis': [661, 2344], 'factor-α': [662, 2345], 'inhibitor-1;': [664], 'PBS,': [665, 2577, 2773], 'phosphate-buffered': [666], 'saline;': [667], 'PDGF,': [668], 'platelet-derived': [669], 'growth': [670, 2132], 'factor.': [671], 'into': [672, 2697, 2825, 3015, 3252], 'senile': [673], 'plaques.': [674], 'Aβ': [675, 708, 736, 3314], 'produced': [677, 1979], 'protein': [681, 1701, 2221, 2228, 3594], '(APP)': [682], 'sequential': [684], 'β-': [685], 'cleavages.': [688, 734], 'An': [689, 1955], 'alternative': [690], 'β-secretase': [693], 'pathway': [694, 1322], 'α-secretase,': [700], 'cuts': [702], 'middle': [705], 'region': [709], 'APP': [711, 723, 1473, 3328], '(1Selkoe': [712], 'D.J.': [713, 904, 3296], 'Nature.': [714, 985, 1668], '1999;': [715, 986, 1242, 1533, 1808], '399:': [716], 'A23-A31Crossref': [717], 'PubMed': [718, 778, 797, 835, 888, 917, 955, 989, 1011, 1033, 1050, 1064, 1133, 1165, 1185, 1206, 1228, 1250, 1303, 1342, 1355, 1411, 1458, 1505, 1536, 1593, 1639, 1672, 1709, 1731, 1742, 1786, 1816, 1842, 2095, 2386, 2414, 2635, 2806, 2943, 3148, 3170, 3223, 3271, 3284, 3308, 3365, 3391, 3421, 3448, 3491, 3513, 3547, 3609, 3688, 3738, 3753, 3770, 3792, 4003, 4047], 'Scopus': [719, 779, 798, 836, 889, 918, 956, 990, 1012, 1034, 1051, 1065, 1134, 1166, 1186, 1207, 1229, 1251, 1304, 1343, 1356, 1412, 1459, 1506, 1537, 1673, 1732, 1743, 1787, 1817, 1843, 2096, 2387, 2415, 2807, 2944, 3149, 3171, 3224, 3272, 3285, 3309, 3366, 3392, 3422, 3449, 3492, 3514, 3548, 3689, 3739, 3754, 3771, 3793, 4004, 4048], '(1526)': [720], 'Google': [721, 781, 800, 838, 891, 920, 958, 992, 1014, 1036, 1053, 1067, 1136, 1168, 1188, 1209, 1231, 1253, 1306, 1345, 1358, 1398, 1414, 1461, 1508, 1539, 1594, 1640, 1675, 1710, 1734, 1745, 1789, 1819, 1845, 2098, 2389, 2417, 2636, 2809, 2946, 3151, 3173, 3226, 3274, 3287, 3311, 3368, 3394, 3424, 3451, 3494, 3516, 3550, 3610, 3691, 3741, 3756, 3773, 3795, 4006, 4050], 'Scholar).': [722, 801, 839, 921, 1068, 1254, 1307, 1359, 1415, 1462, 1540, 1595, 1641, 1676, 1746, 1846, 2099, 2418, 2810, 3312, 3452, 3551, 3611, 3692, 4007, 4051], 'has': [724, 3658], 'been': [725, 749, 1616, 3660], 'shown': [726, 750, 3968, 4147], 'serially': [728], 'undergo': [729, 3704], 'either': [730, 848], 'β-γ': [731], 'α-γ': [733], 'Both': [735], 'β-secretase-mediated': [739], 'product': [742], 'C99': [745], 'CTFβ,': [747], 'have': [748, 1615, 4146], 'contribute': [752], 'neurodegeneration': [754], '(2McPhie': [758], 'D.L.': [759], 'Golde': [760, 3762], 'T.': [761, 1177, 1295, 2396, 3347, 3401, 3539, 4329], 'Eckman': [762], 'C.B.': [763], 'Yager': [764], 'D.': [765], 'Brant': [766], 'J.B.': [767, 3292], 'Neve': [768], 'R.L.': [769], 'Brain': [770, 773], 'Res.': [771, 774, 1338], 'Mol.': [772, 3213], '2001;': [775, 1739, 2406, 3268, 3281, 3300, 3357, 3388, 3413, 3767, 4044], '97:': [776, 886], '103-113Crossref': [777], '(57)': [780], 'Scholar,': [782, 892, 959, 993, 1015, 1037, 1054, 1137, 1169, 1189, 1210, 1232, 1346, 1399, 1509, 1711, 1735, 1790, 1820, 2390, 3152, 3275, 3288, 3369, 3395, 3425, 3495, 3517, 3742, 3757, 3774], '3Ling': [783], 'Y.': [784, 1017, 1171, 1479, 2392, 2402, 3154, 3343, 3353, 3497], 'Morgan': [785], 'K.': [786, 970, 1039, 1173, 1175, 1715, 1770, 2400, 2625, 3260, 3351, 3375, 3435, 3441], 'Kalsheker': [787], 'N.': [788, 1139, 1331, 2398, 3349, 3667], 'Int.': [789], 'J.': [790, 867, 1000, 1022, 1044, 1191, 1217, 1277, 1299, 1392, 1494, 1720, 1775, 1805, 1831, 2084, 2375, 2403, 2626, 2800, 2932, 3137, 3159, 3266, 3297, 3354, 3410, 3480, 3502, 3521, 3543, 3682, 3727, 3780, 3781, 3983, 3992, 4043], 'Biochem.': [791, 4042], 'Cell': [792, 1045, 1452, 2801, 2908, 2912, 3683], 'Biol.': [793, 1001, 1023, 1218, 1454, 1495, 1721, 1776, 1806, 1832, 2085, 2376, 2404, 2627, 2802, 2933, 3138, 3160, 3298, 3355, 3411, 3481, 3503, 3684, 3728, 3782, 3993], '2003;': [794, 827, 947, 1025, 1182, 2803, 2935, 3162, 3505, 3995], '35:': [795], '1505-1535Crossref': [796], '(172)': [799], 'multisubunit': [805], 'aspartyl': [806], 'protease': [807, 2200, 2441, 3978], 'complex,': [808], 'harboring': [809], '1': [811, 2186, 2458, 2502, 2664], '(PS1)': [812], '2': [814], '(PS2),': [815], 'nicastrin,': [816], 'aph-1,': [817], 'pen2,': [818], 'likely': [820, 1549], 'additional': [821, 935, 4202], 'factors': [822], '(4De': [823, 943], 'Strooper': [824, 944, 961, 1448, 3264], 'B.': [825, 945, 962, 1449, 3265], 'Neuron.': [826, 946, 1156, 1241], '38:': [828, 948], '9-12Abstract': [829, 949], 'Full': [830, 832, 950, 952, 1006, 1008, 1028, 1030, 1160, 1162, 1223, 1225, 1245, 1247, 1500, 1502, 1726, 1728, 1781, 1783, 1811, 1813, 1837, 1839, 2090, 2092, 2381, 2383, 2409, 2411, 2632, 2938, 2940, 3143, 3145, 3165, 3167, 3218, 3220, 3303, 3305, 3360, 3362, 3416, 3418, 3486, 3488, 3508, 3510, 3733, 3735, 3787, 3789, 3998, 4000], 'Text': [831, 833, 951, 953, 1007, 1009, 1029, 1031, 1161, 1163, 1224, 1226, 1246, 1248, 1501, 1503, 1727, 1729, 1782, 1784, 1812, 1814, 1838, 1840, 2091, 2093, 2382, 2384, 2410, 2412, 2633, 2939, 2941, 3144, 3146, 3166, 3168, 3219, 3221, 3304, 3306, 3361, 3363, 3417, 3419, 3487, 3489, 3509, 3511, 3734, 3736, 3788, 3790, 3999, 4001], '(838)': [837, 957, 1507], 'presenilins': [841], 'are': [842, 1078, 1466, 2006, 2741, 3714, 4308], 'polytopic': [843], 'proteins': [845, 1082, 3570, 4307], 'constitute': [847], 'catalytic': [849], 'subunits': [850, 1608, 1631, 4316], 'necessary': [852], 'cofactors': [853], 'complex': [857, 1273], '(5Li': [858], 'Y.M.': [859], 'Lai': [860, 1150], 'M.T.': [861], 'Xu': [862, 3402], 'M.': [863, 1147, 1238, 1388, 1521, 1717, 1772, 1802, 2333, 2619, 2623, 3371, 3433], 'Huang': [864], 'Q.': [865], 'DiMuzio-Mower': [866], 'Sardana': [868], 'M.K.': [869], 'Shi': [870], 'X.P.': [871], 'Yin': [872], 'K.C.': [873], 'Shafer': [874], 'J.A.': [875, 2791], 'Gardell': [876], 'S.J.': [877, 2793], 'Proc.': [878, 907, 1196, 1526], 'Natl.': [879, 908, 1197, 1527], 'Acad.': [880, 909, 1198, 1528], 'Sci.': [881, 910, 1046, 1181, 1199, 1529], 'U.': [882, 911, 1200, 1530], 'S.': [883, 912, 1201, 1283, 1291, 1511, 1517, 1531, 2927, 3429, 3527, 3535, 3744, 3746], 'A.': [884, 913, 982, 1202, 1281, 1401, 1532, 3212, 3377, 3427, 3525, 3677, 3679, 3985, 3989], '2000;': [885, 1339, 1395, 1723, 1778, 3215, 3750], '6138-6143Crossref': [887], '(499)': [890], '6Esler': [893], 'W.P.': [894], 'Kimberly': [895], 'W.T.': [896, 3290], 'Ostaszewski': [897], 'B.L.': [898], 'Ye': [899], 'W.': [900, 964, 1179, 1446, 3262], 'Diehl': [901], 'T.S.': [902], 'Selkoe': [903, 3295], 'Wolfe': [905, 977, 2334], 'M.S.': [906, 978], '2002;': [914, 1003, 1220, 1300, 1455, 1590, 1636, 1706, 2087, 2378, 3140, 3445, 3483, 3544, 3606, 3730, 3784], '99:': [915], '2720-2725Crossref': [916], '(344)': [919], 'Besides': [922], 'intramembraneous': [929, 3324], 'cleavages': [930], 'at': [932, 2149, 2210, 2245, 2275, 2454, 2488, 2514, 2660, 2710, 2747, 2750, 3127, 3332, 3463, 3839], 'least': [933, 2889], '15': [934, 2658, 4059, 4155], 'proteins,': [936, 3621], 'including': [937, 3576, 3622, 4134], 'Notch,': [938], 'nectin-1α,': [939, 3845], 'recently': [941, 1603, 3659], 'NRADD': [942], '7De': [960], 'Annaert': [963, 3261], 'Cupers': [965], 'P.': [966, 968, 1275, 1289, 3256, 3519, 3533, 3675, 3776], 'Saftig': [967], 'Craessaerts': [969, 3259], 'Mumm': [971], 'J.S.': [972], 'Schroeter': [973], 'E.H.': [974, 1056, 1125], 'Schrijvers': [975], 'V.': [976, 1285, 1828, 3529], 'Ray': [979], 'W.J.': [980, 1348], 'Goate': [981], 'Kopan': [983, 1057, 1126], 'R.': [984, 1058, 1127, 1350, 1515, 1519, 3407], '398:': [987], '518-522Crossref': [988], '(1800)': [991], '8Kim': [994], 'D.Y.': [995, 1216, 2079, 2370, 3132, 3475, 3722], 'Ingano': [996, 2080, 2371, 3133, 3476, 3723], 'L.A.': [997, 2081, 2372, 3134, 3477, 3724], 'Kovacs': [998, 2082, 2373, 3135, 3478, 3725], 'D.M.': [999, 1240, 2083, 2374, 3136, 3479, 3726], 'Chem.': [1002, 1024, 1219, 1496, 1722, 1777, 1807, 1833, 2086, 2377, 2405, 2628, 2934, 3139, 3161, 3299, 3356, 3412, 3482, 3504, 3729, 3783, 3994], '277:': [1004, 1221, 2088, 2379, 3141, 3484, 3731, 3785], '49976-49981Abstract': [1005, 2089, 2380, 3142, 3485, 3732], '(162)': [1013, 2097, 2388, 3150, 3493, 3740], '9Taniguchi': [1016, 3153, 3496], 'Kim': [1018, 3155, 3398, 3498], 'S.H.': [1019, 3156, 3399, 3499], 'Sisodia': [1020, 1402, 2040, 3157, 3408, 3500], 'S.S.': [1021, 1403, 3158, 3409, 3501], '278:': [1026, 2936, 3163, 3506, 3996], '30425-30428Abstract': [1027, 3164, 3507], '(105)': [1035, 3172, 3515], '10Gowrishankar': [1038], 'Zeidler': [1040], 'M.G.': [1041, 2929], 'Vincenz': [1042], 'C.': [1043, 1149, 1151, 1523, 1826, 3385, 3397, 3681, 3991], '2004;': [1047, 1061, 1130, 1157, 1203, 1352, 1408, 1834, 3685], '117:': [1048], '4099-4111Crossref': [1049], '(41)': [1052, 1413], '11Koo': [1055], 'Nat.': [1059, 1128], 'Med.': [1060, 1129], '10:': [1062, 1131], 'S26-S33Crossref': [1063, 1132], '(152)': [1066, 1135], 'All': [1069, 1596], 'known': [1071, 1617, 4091], 'substrates,': [1072, 3696], 'exception': [1075], 'GluR3,': [1077], 'type': [1079, 2969], 'I': [1080], 'require': [1084], 'extracellular': [1085, 1760, 3197], 'prior': [1088], 'subsequent': [1090], 'γ-cleavage.': [1091], 'many': [1093, 3239], 'substrates': [1095, 1547, 1648, 2308, 3118, 3126, 3457], '(E-,': [1096], 'N-cadherin,': [1097], 'nectin-1,': [1098, 3703], 'CD44,': [1099], 'ErbB4,': [1101], 'p75NTR,': [1102], 'APOER2,': [1103], 'LRP,': [1104, 3701], 'syndecan-3,': [1105], 'DCC)': [1107], 'share': [1108], 'functions': [1109], 'and/or': [1113, 1381], 'migration,': [1114], 'implicating': [1115], 'possible': [1117], 'these': [1122, 2004, 4097, 4128], 'processes': [1123], '(11Koo': [1124], '12Flames': [1138], 'Long': [1140], 'J.E.': [1141], 'Garratt': [1142], 'A.N.': [1143], 'Fischer': [1144], 'T.M.': [1145], 'Gassmann': [1146], 'Birchmeier': [1148], 'Rubenstein': [1152], 'J.L.': [1153, 1481], 'Marin': [1154], 'O.': [1155, 3671], '44:': [1158], '251-261Abstract': [1159], '(360)': [1167], '13Takai': [1170], 'Irie': [1172], 'Shimizu': [1174], 'Sakisaka': [1176], 'Ikeda': [1178], 'Cancer': [1180, 1337], '94:': [1183], '655-667Crossref': [1184], '(289)': [1187], '14Yamauchi': [1190], 'Chan': [1192], 'J.R.': [1193], 'Shooter': [1194], 'E.M.': [1195], '101:': [1204], '8774-8779Crossref': [1205], '(145)': [1208], '15Swertfeger': [1211], 'D.K.': [1212], 'Bu': [1213], 'G.': [1214, 1279, 3210, 3379, 3437, 3443, 3523, 3765], 'Hui': [1215], '4141-4146Abstract': [1222], '(58)': [1230], '16Yee': [1233], 'K.T.': [1234], 'Simon': [1235], 'H.H.': [1236], 'Tessier-Lavigne': [1237], "O'Leary": [1239], '24:': [1243], '607-622Abstract': [1244], '(233)': [1252], 'For': [1255, 2811, 4096], 'example,': [1256], 'γ-secretase-dependent': [1257], 'E-cadherin,': [1260], 'well': [1262, 1695, 4090], 'characterized': [1263, 1470, 1696], 'molecule,': [1266], 'promotes': [1267], 'disassembly': [1268], 'E-cadherin-catenin': [1271], '(17Marambaud': [1274], 'Shioi': [1276, 3520], 'Serban': [1278, 3522], 'Georgakopoulos': [1280, 3524], 'Sarner': [1282, 3526], 'Nagy': [1284, 3528], 'Baki': [1286, 3530], 'L.': [1287, 3405, 3531], 'Wen': [1288, 3532], 'Efthimiopoulos': [1290, 3534], 'Shao': [1292, 3536], 'Z.': [1293, 2789, 3537], 'Wisniewski': [1294, 3538], 'Robakis': [1296, 3540], 'N.K.': [1297, 3541], 'EMBO': [1298, 3386, 3542], '21:': [1301, 3545], '1948-1956Crossref': [1302, 3546], '(624)': [1305, 3549], 'This': [1308, 3862, 4163], 'results': [1309], 'release': [1312], 'β-catenin,': [1314], 'key': [1316], 'mediator': [1317], 'Wnt': [1320], 'signaling': [1321], 'controls': [1324], '(18Barker': [1330], 'Morin': [1332], 'P.J.': [1333, 2795], 'Clevers': [1334], 'H.': [1335, 2394, 2621, 3345, 3373, 3403], 'Adv.': [1336], '77:': [1340], '1-24Crossref': [1341], '(260)': [1344, 3794], '19Nelson': [1347], 'Nusse': [1349], 'Science.': [1351, 3280, 3766], '303:': [1353], '1483-1487Crossref': [1354], '(2242)': [1357], 'Studies': [1360], 'on': [1361, 1431, 2124, 2231, 3050, 3557], 'central': [1362, 1685], 'nervous': [1363, 1686], 'system': [1364], 'morphogenesis': [1365], 'PS1': [1367], 'mice': [1369], 'strongly': [1371], 'support': [1372], 'function': [1374, 1764], 'during': [1384, 2065], 'brain': [1385], 'development': [1386], '(20Handler': [1387], 'Yang': [1389], 'X.': [1390, 3277], 'Shen': [1391], 'Development': [1393, 1406], '(Camb.).': [1394, 1407], '127:': [1396], '2593-2606PubMed': [1397], '21Louvi': [1400], 'Grove': [1404], 'E.A.': [1405], '131:': [1409], '3093-3105Crossref': [1410], 'α-Secretase': [1416, 3109], 'generic': [1419, 1435], 'name': [1420], 'several': [1422], 'ectodomain-shedding': [1423], 'proteases,': [1424], 'primarily': [1425], 'metalloprotease': [1428, 1436, 3975], 'type,': [1429], 'based': [1430, 3556], 'their': [1432, 1758, 1763], 'sensitivity': [1433], 'inhibitors': [1437, 2317, 4209], 'inducible': [1439, 3879], 'activation': [1440], 'phorbol': [1442, 3705, 3811, 3877], 'ester': [1443, 3878], '(22Annaert': [1445], 'De': [1447, 3263, 4321], 'Annu.': [1450], 'Rev.': [1451], 'Dev.': [1453], '18:': [1456], '25-51Crossref': [1457], '(198)': [1460], 'ADAM-10': [1463], 'ADAM-17': [1465], 'among': [1467, 3114], 'best': [1469], 'α-secretases': [1471], '(23Buxbaum': [1474], 'J.D.': [1475, 1713, 1768, 1796], 'Liu': [1476], 'K.N.': [1477], 'Luo': [1478], 'Slack': [1480], 'Stocking': [1482], 'K.L.': [1483], 'Peschon': [1484], 'J.J.': [1485], 'Johnson': [1486], 'R.S.': [1487], 'Castner': [1488], 'B.J.': [1489], 'Cerretti': [1490], 'D.P.': [1491, 1822], 'Black': [1492], 'R.A.': [1493], '1998;': [1497], '273:': [1498], '27765-27767Abstract': [1499], '24Lammich': [1510], 'Kojro': [1512], 'E.': [1513, 3669], 'Postina': [1514], 'Gilbert': [1516], 'Pfeiffer': [1518], 'Jasionowski': [1520], 'Haass': [1522, 3384], 'Fahrenholz': [1524], 'F.': [1525, 3673], '96:': [1534], '3922-3927Crossref': [1535], '(985)': [1538], 'Ectodomain': [1541], 'currently': [1544, 3115], 'reported': [1545, 3116, 3661, 3694], 'be': [1551, 1569, 1619], 'α-secretase-like': [1554, 4132], 'metalloproteases.': [1555], 'However,': [1556, 3927], 'identity': [1558], 'metalloproteases': [1561], 'responsible': [1562, 4080, 4169, 4225], 'each': [1564, 2863], 'remains': [1567], 'elucidated.': [1570], 'Voltage-gated': [1571], 'channels': [1573], 'consist': [1574], 'single': [1577], 'pore-forming': [1578], 'α': [1579, 1630, 1692, 3623, 4315], 'one': [1582], 'two': [1584, 4201], 'β-subunits': [1585, 1653], '(25Isom': [1586, 1632, 1702, 3602], 'L.L.': [1587, 1633, 1665, 1703, 1719, 1737, 1774, 1804, 1830, 3603, 4318], 'Front.': [1588, 1634, 1704, 3604], 'Biosci.': [1589, 1635, 1705, 3605], '7:': [1591, 1637, 1707, 1740, 3607], '12-23Crossref': [1592, 1638, 1708, 3608], 'β-subunits,': [1597], 'β1,': [1598], '1A,': [1599], '2,': [1600], '3,': [1601], '4,': [1604], 'serve': [1605], 'involved': [1620, 4015], 'gating': [1624], 'surface': [1627, 3053, 3083], 'Similarly': [1642], 'DCC,': [1646, 3588], 'PS/γ-secretase-mediated': [1650, 1877], 'cleavages,': [1651], 'belong': [1654], 'immunoglobulin': [1657], 'molecules': [1662], '(CAMs)': [1663], '(26Isom': [1664], 'Catterall': [1666, 4330], 'W.A.': [1667, 4331], '1996;': [1669], '383:': [1670], '307-308Crossref': [1671], '(100)': [1674], 'β2-subunit,': [1678], 'particular,': [1680], 'enriched': [1682], 'system,': [1687], 'covalently': [1688], 'linked': [1689], 'subunit,': [1693], '27Malhotra': [1712], 'Kazen-Gillespie': [1714, 1769], 'Hortsch': [1716, 1771], 'Isom': [1718, 1773, 1803, 1829], '275:': [1724, 1779], '11383-11388Abstract': [1725, 1780], '(247)': [1733, 1788], '28Isom': [1736], 'Neuroscientist.': [1738], '42-54Crossref': [1741], '(284)': [1744], 'β2-Subunits': [1747], 'interact': [1748], 'homophilically,': [1749], 'heterophilically': [1752], 'tenascin-R': [1754], 'β1-subunits': [1756], 'via': [1757, 1919], 'N-CAM-like': [1759], 'domains,': [1761], 'mediating': [1762], 'CAMs': [1766], '(27Malhotra': [1767], '29Xiao': [1791], 'Z.C.': [1792], 'Ragsdale': [1793, 4319], 'D.S.': [1794, 4320], 'Malhotra': [1795], 'Mattei': [1797], 'L.N.': [1798], 'Braun': [1799], 'P.E.': [1800], 'Schachner': [1801], '274:': [1809], '26511-26517Abstract': [1810], '(189)': [1818], '30McEwen': [1821], 'Meadows': [1823], 'L.S.': [1824], 'Chen': [1825], 'Thyagarajan': [1827], '279:': [1835], '16044-16049Abstract': [1836], '(94)': [1844], 'report': [1849], 'identification': [1851], 'TPA': [1861, 3908, 4270], 'ADAM10': [1864, 1960, 4103, 4111, 4135], 'induce': [1866, 2642], 'membrane-anchored': [1874], 'generate': [1880, 2003, 3188], '12-kDa': [1882], '(β2-ICD).': [1886], 'Lack': [1887], 'resulting': [1893], 'accumulation': [1895, 3192, 4056], 'inhibits': [1898], 'CHO': [1904, 1982, 3815, 4021, 4120, 4159, 4198, 4252], 'These': [1906, 3948, 4208, 4290], 'data': [1907, 3949, 4129, 4291], 'suggest': [1908, 3950], 'β2-CTFs.': [1922], 'Plasmids,': [1923], 'Transfection,': [1924], 'Primary': [1926, 2241], 'Neuronal': [1927], 'Cultures—An': [1928], 'construct': [1930, 4104, 4258], 'encoding': [1931], 'full-length': [1932, 3836, 4286], 'human': [1933, 1959], '(β2,': [1939], 'GeneBank™': [1940], 'accession': [1941], 'number': [1942, 2719, 2744, 3568], 'gi:21361089)': [1943], 'containing': [1944, 1958, 2180, 2568, 2670, 2692, 3571], 'V5/His': [1947], 'tag': [1948], '(in': [1949], 'pcDNA3.1/GS)': [1950], 'purchased': [1952, 2350], 'Invitrogen.': [1954], 'vector': [1957], 'kind': [1963, 2270, 2329], 'gift': [1964, 2037, 2271, 2330], 'Dr.': [1966, 2039, 2273, 2332, 4106], 'Lichtenthaler': [1967, 4107], '(Ludwig-Maximilians-Universität).': [1968, 4108], 'Effectene': [1969], '(Qiagen)': [1970], 'routinely': [1972, 2047], 'transfecting': [1975], 'lines.': [1977], 'stably': [1980, 4254], 'transfected': [1981, 4255, 4284], 'nectin,': [1988], 'wild-type': [1991, 2030], 'PS1(D385A)': [1994], 'constructs.': [1996], 'sequences': [1998], 'primers': [2000], 'constructs': [2005], 'available': [2007], 'request.': [2009], 'Individual': [2010], 'clones': [2011], 'similar': [2013, 3870], 'were': [2016, 2034, 2046, 2074, 2102, 2122, 2147, 2171, 2216, 2229, 2243, 2298, 2321, 2365, 2422, 2447, 2480, 2526, 2548, 2579, 2592, 2610, 2646, 2654, 2684, 2761, 2815, 2836, 2893, 2918, 2965, 2980, 3000, 3013, 3057, 3087, 4025], 'maintained': [2017, 2130, 2148], 'selection': [2019], 'medium.': [2020], 'ES': [2024, 2031, 4282], 'line': [2026], '(BD1)': [2027], 'control': [2029, 3663], '(BD6)': [2033], 'generous': [2036], '(University': [2041], 'Chicago).': [2043], 'SH-SY5Y': [2044, 2978, 3047], 'grown': [2048, 2762], 'DMEM': [2050], 'medium': [2051, 2063, 2137, 2139, 2986], '(Cambrex)': [2052, 2064], '10%': [2054, 2433], 'fetal': [2055, 2107], 'bovine': [2056, 2703], 'serum': [2057, 2704], 'switched': [2059], 'RPMI': [2061, 2984], '1640': [2062, 2985], 'assays.': [2067], 'Mouse': [2068], 'cortical': [2070], 'cultures': [2072], '(DIV16)': [2073], 'prepared': [2075, 2172], 'described': [2077, 2368, 2613, 2921], '(8Kim': [2078, 2369, 3131, 3474, 3721], 'Briefly,': [2100, 2951], 'cortices': [2101], 'dissected': [2103], 'E16': [2105], 'brains': [2108], 'dissociated': [2110, 2120], 'repeated': [2112], 'passages': [2113], 'through': [2114], 'fire-polished': [2116], 'Pasteur': [2117], 'pipette.': [2118], 'plated': [2123], 'l-polylysine/laminine': [2125], 'coated': [2126, 2966], '6-well': [2127, 2975, 3021], 'dishes': [2128, 2700], 'media': [2133], 'consisting': [2134], 'neurobasal': [2136], '(Invitrogen)': [2138], 'supplemented': [2140], 'B27': [2142], '0.5': [2144], 'mml-glutamine.': [2145], 'Cultures': [2146], '37': [2150, 2455], '°C': [2151, 2456], 'humidified': [2154], '5%': [2155], 'CO2': [2156], 'atmosphere': [2157], '16': [2159], 'days': [2160], '(DIV16).': [2161], 'Western': [2162, 3831], 'Blot': [2163], 'Analysis,': [2164], 'Antibodies,': [2165], 'Inhibitors—For': [2167], 'immunoblotting,': [2168], 'extracts': [2170], 'extracting': [2175], 'buffer': [2179], '10': [2181, 4028], 'mm': [2182, 2187, 2190, 2428, 2431, 2436, 2503, 2665], 'Tris-HCl,': [2183], 'pH': [2184, 2438], '6.8,': [2185], 'EDTA,': [2188, 2437], '150': [2189, 2430], 'NaCl,': [2191, 2432], '0.25%': [2192], 'Nonidet': [2193], 'P-40,': [2194], '1%': [2195], 'Triton': [2196, 2538], 'X-100,': [2197], 'mixture': [2202, 2487], '(Roche': [2203], 'Applied': [2204], 'Science),': [2205], 'spin': [2209], '16,000': [2211], '×': [2212, 2490, 2516, 3010], 'g.': [2213], 'Protein': [2214], 'quantitated': [2217, 3094], 'using': [2218, 2302, 2536, 2594, 2878], 'BCA': [2220], 'kit': [2223], '(Pierce).': [2224], '20–100': [2225], 'μg': [2226], 'resolved': [2230], '4–12%': [2232], 'gradient': [2233], 'BisTris': [2234, 2238], 'gels': [2235, 2239], '12%': [2237], '(Invitrogen).': [2240], 'antibodies': [2242, 2258, 2583], 'following': [2247], 'dilutions:': [2248], 'anti-V5': [2249, 2562], 'antibody': [2250, 2563, 3824], '(1:5000': [2251], 'dilution': [2252, 2261, 2268], '(Invitrogen)),': [2253], 'anti-sodium': [2254], '(Navβ2,': [2259], '1:500': [2260, 2264], '(Chemicon)': [2262], '(USBiological)),': [2265], 'anti-nectin-1': [2266], '(1:1000': [2267, 2282, 2287], '(a': [2269], 'Federoff': [2274], 'University': [2277], 'Rochester)),': [2279], 'anti-transferrin': [2280], 'receptor': [2281], '(BD': [2283], 'Bioscience)),': [2284], 'anti-poly-(d-ribose)': [2285], 'polymerase': [2286], '(Pharmingen)),': [2288], 'anti-cleaved': [2290], 'caspase': [2291], '3': [2292, 2558], '(1:2000': [2293], '(Cell': [2294], 'Signaling)).': [2295], 'blots': [2297], 'visualized': [2299], 'ECL': [2301], 'Lumiglo': [2303], '(KPL)': [2304], 'SuperSignal': [2306], 'CL-HRP': [2307], '(Pierce)': [2309], 'according': [2310], "manufacturer's": [2313], 'instructions.': [2314], 'L-685,458': [2320, 4205], 'obtained': [2322, 2593, 2837, 4100], 'Calbiochem,': [2324], 'WPE31C': [2326], '(Brigham': [2335], "Women's": [2337], 'Hospital).': [2338], 'TAPI-1': [2342, 4070], '(tumor': [2343], 'inhibitor-1,': [2347], 'IC-2)': [2348], 'Biomol.': [2352], 'Vitro': [2354], 'Generation': [2355], 'β2-ICD—Membrane': [2357], 'preparation': [2358], 'vitro': [2361, 2444, 2606], 'β2-ICD': [2364], 'performed': [2366, 2448, 2611, 2919], '31Gu': [2391], 'Misonou': [2393, 3344], 'Sato': [2395, 3346], 'Dohmae': [2397, 3348], 'Takio': [2399, 3350], 'Ihara': [2401, 3352], '276:': [2407, 3301, 3358, 3414], '35235-35238Abstract': [2408, 3359], '(269)': [2416, 3367], 'P2-P3': [2420], 'fractions': [2421, 2453], 'resuspended': [2423, 2685], 'Buffer': [2425], 'H': [2426], '(20': [2427, 3034], 'HEPES,': [2429], 'glycerol,': [2434], '5': [2435, 2597], '7.4)': [2439], 'inhibitors.': [2442], 'experiments': [2446], 'incubating': [2450], 'h': [2459, 2559, 2778, 2844, 2989, 3027], 'presence': [2462, 2781, 2992], 'absence': [2464, 2783, 2994], 'indicated': [2467, 2715], 'amounts': [2468], 'L-685,458.': [2472], 'After': [2473, 2572, 2679], 'incubation,': [2474], 'soluble': [2476], 'membrane-associated': [2478], 'fragments': [2479, 2498], 'separated': [2481], 'centrifugation': [2483], 'reaction': [2486], '120,000': [2489, 2515], 'g': [2491, 2517], '45': [2493, 2519], 'min.': [2494, 2520], 'dissociate': [2496], 'ICD': [2497, 3248], 'membranes,': [2501], 'NaOH': [2504], 'solution': [2505, 2669, 2691, 3006], 'added': [2507, 3038], 'fraction': [2511], 'centrifuged': [2513], 'Fluorescence': [2521], 'Confocal': [2522, 2589], 'Analysis—For': [2523], 'immunostaining,': [2524], 'fixed': [2527], '4%': [2529], 'paraformaldehyde,': [2530], 'rinsed,': [2531], 'permeabilized,': [2532], '0.1%': [2537], 'X-100': [2539], '1.5%': [2541, 2569], 'goat': [2542, 2570], 'IgG': [2543], '(Molecular': [2544, 3091], 'Probes),': [2545], 'respectively.': [2546, 2754], 'Cells': [2547, 2653, 2999, 3049, 3074], 'then': [2549, 2655, 3001], 'washed': [2550, 2771], 'times': [2552, 2575, 2726], 'PBS': [2554, 2567], 'incubated': [2556, 2580, 2656, 2775, 3024], '(1:200,': [2564], 'Invitrogen)': [2565], 'IgG.': [2571], 'washing': [2573, 2680], 'secondary': [2582], 'conjugated': [2584], 'Alexa': [2586], 'Fluor': [2587], '488.': [2588], 'fluorescence': [2590, 3098], 'images': [2591, 2835], 'LSM': [2596], 'Pascal': [2598], 'laser': [2599], 'scanning': [2600], 'microscope': [2601], '(Zeiss).': [2602], 'Cell-Cell': [2603], 'Aggregation': [2604, 2730], 'Assay—In': [2605], 'assays': [2609, 2917], 'Miura': [2615], 'et': [2616, 2924], 'al.': [2617, 2925], '(32Miura': [2618], 'Asou': [2620], 'Kobayashi': [2622], 'Uyemura': [2624], '1992;': [2629], '267:': [2630], '10752-10758Abstract': [2631], 'Scholar)': [2637, 2947, 3796], 'slight': [2639, 2949], 'modifications.': [2640, 2950], 'accumulation,': [2644, 2813], 'pretreated': [2647, 2816], 'h.': [2652, 2821], 'min': [2659], 'room': [2661, 2711], 'temperature': [2662, 2712], "EDTA/Hanks'": [2666], 'balanced': [2667, 2689], 'salt': [2668, 2690], '500': [2671, 2785, 2996], 'nm': [2672, 2786, 2997], 'dispersed': [2675, 3002], 'gentle': [2677], 'pipetting.': [2678], 'times,': [2682], 'Ca2+/Mg2+-free': [2687], "Hanks'": [2688], '(500': [2694], 'nm),': [2695], 'transferred': [2696], '35-mm': [2698], 'polysterene': [2699], 'precoated': [2701], 'albumin,': [2705], 'agitated': [2707], '(75': [2708], 'rpm)': [2709], 'intervals.': [2717], 'aggregates': [2722], 'counted': [2724], 'hemocytometer.': [2729], 'quantified': [2732, 2853], 'index': [2735], 'N(t)/N(0),': [2736], 'where': [2737], 'N(t)': [2738], 'N(0)': [2740], 'total': [2743, 2857], 'particles': [2746], 'incubation': [2748], 't': [2751], '0,': [2753], 'Wound': [2755, 2849], 'Healing': [2756], 'Assay—CHO': [2757], 'monolayer,': [2764], 'scraped': [2765], 'P200': [2768], 'pipette': [2769], 'tip,': [2770], '18–21': [2777], '(33Mostafavi-Pour': [2788], 'Askari': [2790], 'Parkinson': [2792], 'Parker': [2794], 'Ng': [2796], 'T.T.': [2797], 'Humphries': [2798], 'M.J.': [2799], '161:': [2804], '155-167Crossref': [2805], '(183)': [2808], 'Migration': [2822, 2909], 'examined': [2829], 'phase': [2831], 'contrast': [2832], 'microscopy.': [2833], 'Photographic': [2834], 'immediately': [2838], 'after': [2839, 2842], 'scraping': [2840], '21': [2843], 'same': [2847], 'locations.': [2848], 'activity': [2851, 3245, 4013, 4167, 4223], 'measuring': [2855], 'area': [2858, 2868, 2902], '10×': [2864], 'field': [2865], 'covered': [2869, 2903], 'migrating': [2872], 'within': [2874], 'public': [2879], 'image': [2880, 2884], 'analysis': [2881, 3833], 'software,': [2882, 2885], 'NIH': [2883], 'Version': [2886], '1.61.': [2887], 'At': [2888], 'different': [2891], 'fields': [2892], 'chosen': [2894], 'randomly,': [2895], 'mean': [2898], 'percentage': [2899], 'calculated.': [2907], 'Assay': [2910], 'Culture': [2913], 'Inserts—SH-SY5Y': [2914], 'Pola': [2923], '(34Pola': [2926], 'Cattaneo': [2928], 'Vicentini': [2930], 'L.M.': [2931], '40601-40606Abstract': [2937], '(47)': [2945], 'culture': [2953, 3017], 'inserts': [2954, 3018, 3056, 3086], 'polyethylene': [2956], 'terephthalate': [2957], 'membranes': [2958], '(8': [2959], 'μm': [2960, 4029], 'pore,': [2961], 'USA': [2962], 'Scientific,': [2963], 'Inc.)': [2964], 'collagen': [2968], 'IV': [2970], '(Sigma)': [2971], 'placed': [2973, 3019], 'dishes.': [2976], 'Confluent': [2977], 'preincubated': [2981], 'serum-free': [2983], '24': [2988, 3026], 'DAPT.': [2998], '0.02%': [3004], 'EDTA': [3005], 'PBS.': [3008], '4': [3009], '105': [3011], 'replated': [3014], 'plates': [3022], 'allow': [3029], 'PDGF-BB': [3033], 'ng/ml,': [3035], 'Sigma)': [3036], 'lower': [3041, 3082], 'attractant': [3045], 'upper': [3052], 'removed': [3058], 'sterile': [3060], 'scraper': [3062], '(Falcon),': [3063], 'leave': [3065], 'had': [3069, 3076], 'migrated': [3070, 3077, 3838], 'across': [3071], 'membrane.': [3073, 3907], 'attached': [3079], 'stained': [3088], 'Hoechst33342': [3090], 'Probes)': [3092], 'Victor3': [3097], 'plate': [3099], 'reader': [3100], '(PerkinElmer': [3101], 'Life': [3102], 'Sciences).': [3103], 'Is': [3105], 'Sequentially': [3106], 'Cleaved': [3107], 'PS/γ-Secretase': [3111], 'Activities—Common': [3112], 'characteristics': [3113], 'include:': [3119], '1)': [3120], 'sequence': [3121, 3462, 3631], 'homology': [3122, 3559, 3632], 'other': [3124, 3455], 'membrane-cytosol': [3129, 3465], 'interface': [3130], 'Scholar);': [3174, 3227], '2)': [3175], 'alone': [3180, 3932, 4054, 4112], 'α-': [3183], 'β-secretase-like': [3185], 'activities,': [3186], 'CTF': [3189, 3194, 3858, 3945], 'derivatives;': [3190], '3)': [3191], 'derivatives': [3195], 'domains': [3198], 'shorter': [3199, 3805], 'than': [3200], '300': [3201], 'amino': [3202, 3573], 'acids': [3203], 'response': [3205, 3809], 'inhibition': [3208, 4220], '(35Struhl': [3209], 'Adachi': [3211], 'Cell.': [3214, 4332], '6:': [3216], '625-636Abstract': [3217], '(356)': [3225], '4)': [3228], 'detection': [3229], 'PS/γ-secretase-dependent': [3232], 'product,': [3234, 3897], 'termed': [3235], 'ICD;': [3236], '5)': [3237], 'cases,': [3240], 'modulation': [3241], 'nuclear': [3243], 'transcriptional': [3244], 'released': [3251, 3316], 'cytosol': [3254], '(36Cupers': [3255], 'Orlans': [3257], 'I.': [3258, 3981], 'Neurochem.': [3267], '78:': [3269], '1168-1178Crossref': [3270], '(217)': [3273], '37Cao': [3276], 'Sudhof': [3278], 'T.C.': [3279], '293:': [3282], '115-120Crossref': [3283], '(1055)': [3286], '38Kimberly': [3289], 'Zheng': [3291], 'Guenette': [3293], 'S.Y.': [3294], '40288-40292Abstract': [3302], '(397)': [3310], 'Although': [3313], 'APP-CTFβ,': [3321], 'second': [3323], 'clip': [3325], '(ϵ-cleavage)': [3326], 'PS-mediated,': [3331], 'site': [3334, 3646], 'homologous': [3335, 3572], 'S3': [3338], 'Notch': [3341], '(31Gu': [3342], '39Sastre': [3370], 'Steiner': [3372], 'Fuchs': [3374], 'Capell': [3376], 'Multhaup': [3378], 'Condron': [3380], 'M.M.': [3381], 'Teplow': [3382], 'D.B.': [3383], 'Rep.': [3387], '2:': [3389], '835-841Crossref': [3390], '(430)': [3393], '40Yu': [3396], 'Ikeuchi': [3400], 'Gasparini': [3404], 'Wang': [3406], '43756-43760Abstract': [3415], '(200)': [3423], '41Weidemann': [3426], 'Eggert': [3428], 'Reinhard': [3430], 'F.B.': [3431], 'Vogel': [3432], 'Paliga': [3434], 'Baier': [3436], 'Masters': [3438], 'C.L.': [3439], 'Beyreuther': [3440], 'Evin': [3442], 'Biochemistry.': [3444], '41:': [3446], '2825-2835Crossref': [3447], '(319)': [3450], 'Similarly,': [3453, 4274], 'all': [3454], 'harbor': [3458], 'loose': [3460], 'consensus': [3461], 'interface,': [3466], 'corresponding': [3467], 'ϵ/S3-cleavage': [3470, 3562], 'sites': [3471, 3639], 'APP/Notch': [3473], '17Marambaud': [3518], 'Using': [3552], 'BLAST': [3554], 'search': [3555], 'between': [3560], 'sites,': [3563], 'large': [3567], 'acid': [3574], 'sequences,': [3575], 'chose': [3579], 'characterize': [3581], 'because,': [3583], 'similarly': [3584, 3847, 4214], 'belonging': [3595], 'wide': [3598], 'family': [3599], 'IgCAMs': [3601], 'Of': [3612], 'numerous': [3614], 'members': [3615], 'β': [3625], 'subunits,': [3626], 'only': [3627, 3910], 'harbors': [3629], 'strong': [3630], 'APP-ϵ': [3635], 'Notch-S3': [3637, 3664], '(Fig.': [3640, 3797, 3842, 3946, 4071, 4124, 4231, 4245, 4272, 4288], '1A).': [3641], 'this': [3643, 3884, 4063, 4186, 4265], 'putative': [3644], 'contains': [3650], 'lysine': [3652], 'residue': [3653], 'potential': [3655], 'monoubiquitination,': [3656], '(42Gupta-Rossi': [3666], 'Six': [3668], 'LeBail': [3670], 'Logeat': [3672], 'Chastagner': [3674], 'Olry': [3676], 'Israel': [3678], 'Brou': [3680], '166:': [3686], '73-83Crossref': [3687], '(182)': [3690], 'Previously': [3693], 'such': [3697], 'erbB4,': [3700], 'ester-inducible': [3706], 'produce': [3710], 'short': [3711], 'CTFs,': [3712], 'subsequently': [3715], 'cleaved': [3716], 'PS-dependent': [3719], 'manner': [3720], '43Gandy': [3743], 'Petanceska': [3745], 'Biochim.': [3747], 'Biophys.': [3748], 'Acta.': [3749], '1502:': [3751], '44-52Crossref': [3752], '(37)': [3755], '44Ni': [3758], 'C.Y.': [3759], 'Murphy': [3760], 'M.P.': [3761], 'T.E.': [3763], 'Carpenter': [3764], '294:': [3768], '2179-2181Crossref': [3769], '(756)': [3772], '45May': [3775], 'Reddy': [3777], 'Y.K.': [3778], 'Herz': [3779], '18736-18743Abstract': [3786], '1B).': [3798], 'yields': [3804], 'products': [3807], 'esters,': [3812], 'treated': [3814, 4026, 4196], '12-O-tetradecanoylphorbol-13-acetate': [3820], '(TPA).': [3821], 'Employing': [3822], 'against': [3825], 'V5': [3828], 'epitope': [3829], 'tag,': [3830], 'blot': [3832], 'showed': [3834], '∼47': [3840], '1C).': [3843, 3947], 'Unlike': [3844], 'untreated': [3850], 'already': [3852], 'processed': [3853], 'yield': [3856], '∼15': [3860], 'kDa.': [3861], 'indicates': [3863], 'constitutive': [3867], 'addition': [3874], 'activity.': [3880], 'size': [3882], 'consistent': [3887], 'predicted': [3890], 'molecular': [3891], 'mass': [3892], 'β2-CTF-V5/His': [3895], '∼14–15': [3898], 'kDa,': [3899], 'if': [3900], 'occurred': [3903], 'near': [3904], 'plasma': [3906], 'slightly': [3911], 'fragment,': [3917], 'presumably': [3918], 'because': [3919], 'immediate': [3921], 'protein.': [3926], 'DAPT,': [3928, 4216], 'conjunction': [3935], 'further': [3938, 4074, 4267], 'cellular': [3940], 'TPA-inducible': [3954, 3965], 'its': [3963], 'CTF.': [3964], 'Fig.': [3970, 4143], '1C': [3971], 'characteristic': [3973], 'α-secretase-mediated': [3977], 'activities': [3979], '(46Hussain': [3980], 'Hawkins': [3982], 'Shikotra': [3984], 'Riddell': [3986], 'D.R.': [3987], 'Faller': [3988], 'Dingwall': [3990], '36264-36268Abstract': [3997], '(53)': [4005], 'test': [4009], 'hydroxamic': [4032], 'acid-based': [4033], '(47Slack': [4036], 'B.E.': [4037], 'Ma': [4038], 'L.K.': [4039], 'Seah': [4040], 'C.C.': [4041], '357:': [4045], '787-794Crossref': [4046], '(129)': [4049], 'induced': [4055], '1D).': [4072], 'partially': [4079, 4136], 'experiments,': [4098], 'hemagglutinin-tagged': [4102], 'Overexpression': [4109], 'sufficient': [4114], 'increase': [4116], '1E).': [4125], 'Taken': [4126], 'together,': [4127], 'demonstrate': [4130], 'proteases': [4133], 'mediate': [4137], '1,': [4144], 'suggests': [4164], 'degradation': [4172], 'generated': [4177], 'confirm': [4184], 'activity,': [4194], 'β2-transfected': [4197], 'WPE31C.': [4207], 'suggesting': [4217], '2A).': [4232], 'increasing': [4241], 'concentrations': [4242], '2B).': [4246], 'Moreover,': [4247], 'specifically': [4249], 'accumulated': [4250], 'PS1(D385A),': [4263], 'enhanced': [4268], '2C).': [4273], 'largely': [4277], '2D).': [4289], 'proteolytic': [4295], 'PS/γ-secretase-mediated.': [4302], 'cells,': [4305], 'predominantly': [4309], '(48Isom': [4317], 'Jongh': [4322], 'K.S.': [4323], 'Westenbroek': [4324], 'R.E.': [4325], 'Reber': [4326], 'B.F.': [4327], 'Scheuer': [4328]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2041397281', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-11T20:53:52.119528', 'created_date': '2016-06-24'}
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