Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2040009421', 'doi': 'https://doi.org/10.1371/journal.pone.0082457', 'title': 'Reverse Engineering the Neuroblastoma Regulatory Network Uncovers MAX as One of the Master Regulators of Tumor Progression', 'display_name': 'Reverse Engineering the Neuroblastoma Regulatory Network Uncovers MAX as One of the Master Regulators of Tumor Progression', 'publication_year': 2013, 'publication_date': '2013-12-05', 'ids': {'openalex': 'https://openalex.org/W2040009421', 'doi': 'https://doi.org/10.1371/journal.pone.0082457', 'mag': '2040009421', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24349289', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3857773'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0082457', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0082457&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0082457&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029194549', 'display_name': 'Ricardo D’Oliveira Albanus', 'orcid': 'https://orcid.org/0000-0003-3651-0136'}, 'institutions': [{'id': 'https://openalex.org/I130442723', 'display_name': 'Universidade Federal do Rio Grande do Sul', 'ror': 'https://ror.org/041yk2d64', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I130442723']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Ricardo D’Oliveira Albanus', 'raw_affiliation_strings': ['Departamento de Bioquímica, Núcleo de Bioinformática, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquímica, Núcleo de Bioinformática, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.', 'institution_ids': ['https://openalex.org/I130442723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012140349', 'display_name': 'Rodrigo Juliani Siqueira Dalmolin', 'orcid': 'https://orcid.org/0000-0002-1688-6155'}, 'institutions': [{'id': 'https://openalex.org/I130442723', 'display_name': 'Universidade Federal do Rio Grande do Sul', 'ror': 'https://ror.org/041yk2d64', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I130442723']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Rodrigo Juliani Siqueira Dalmolin', 'raw_affiliation_strings': ['Departamento de Bioquímica, Núcleo de Bioinformática, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquímica, Núcleo de Bioinformática, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.', 'institution_ids': ['https://openalex.org/I130442723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059694547', 'display_name': 'Mauro A. A. Castro', 'orcid': 'https://orcid.org/0000-0003-4942-8131'}, 'institutions': [{'id': 'https://openalex.org/I130442723', 'display_name': 'Universidade Federal do Rio Grande do Sul', 'ror': 'https://ror.org/041yk2d64', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I130442723']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Mauro Antônio Alves Castro', 'raw_affiliation_strings': ['Departamento de Bioquímica, Núcleo de Bioinformática, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquímica, Núcleo de Bioinformática, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.', 'institution_ids': ['https://openalex.org/I130442723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084318647', 'display_name': 'Matheus Augusto de Bittencourt Pasquali', 'orcid': 'https://orcid.org/0000-0001-8077-6818'}, 'institutions': [{'id': 'https://openalex.org/I130442723', 'display_name': 'Universidade Federal do Rio Grande do Sul', 'ror': 'https://ror.org/041yk2d64', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I130442723']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Matheus Augusto de Bittencourt Pasquali', 'raw_affiliation_strings': ['Departamento de Bioquímica, Núcleo de Bioinformática, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquímica, Núcleo de Bioinformática, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.', 'institution_ids': ['https://openalex.org/I130442723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034629354', 'display_name': 'Vitor de Miranda Ramos', 'orcid': 'https://orcid.org/0000-0001-7004-0823'}, 'institutions': [{'id': 'https://openalex.org/I130442723', 'display_name': 'Universidade Federal do Rio Grande do Sul', 'ror': 'https://ror.org/041yk2d64', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I130442723']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Vitor de Miranda Ramos', 'raw_affiliation_strings': ['Departamento de Bioquímica, Núcleo de Bioinformática, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquímica, Núcleo de Bioinformática, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.', 'institution_ids': ['https://openalex.org/I130442723']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018877036', 'display_name': 'Daniel Pens Gelain', 'orcid': 'https://orcid.org/0000-0001-5254-0509'}, 'institutions': [{'id': 'https://openalex.org/I130442723', 'display_name': 'Universidade Federal do Rio Grande do Sul', 'ror': 'https://ror.org/041yk2d64', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I130442723']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'Daniel Pens Gelain', 'raw_affiliation_strings': ['Departamento de Bioquímica, Núcleo de Bioinformática, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquímica, Núcleo de Bioinformática, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.', 'institution_ids': ['https://openalex.org/I130442723']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5056281232', 'display_name': 'José Cláudio Fonseca Moreira', 'orcid': 'https://orcid.org/0000-0002-0619-4913'}, 'institutions': [{'id': 'https://openalex.org/I130442723', 'display_name': 'Universidade Federal do Rio Grande do Sul', 'ror': 'https://ror.org/041yk2d64', 'country_code': 'BR', 'type': 'education', 'lineage': ['https://openalex.org/I130442723']}], 'countries': ['BR'], 'is_corresponding': False, 'raw_author_name': 'José Cláudio Fonseca Moreira', 'raw_affiliation_strings': ['Departamento de Bioquímica, Núcleo de Bioinformática, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.'], 'affiliations': [{'raw_affiliation_string': 'Departamento de Bioquímica, Núcleo de Bioinformática, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil.', 'institution_ids': ['https://openalex.org/I130442723']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 1.036, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.870139, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 87, 'max': 88}, 'biblio': {'volume': '8', 'issue': '12', 'first_page': 'e82457', 'last_page': 'e82457'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12226', 'display_name': 'Neuroblastoma Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12226', 'display_name': 'Neuroblastoma Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 0.9939, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9894, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tumor-progression', 'display_name': 'Tumor progression', 'score': 0.69847727}], 'concepts': [{'id': 'https://openalex.org/C2776715637', 'wikidata': 'https://www.wikidata.org/wiki/Q938205', 'display_name': 'Neuroblastoma', 'level': 3, 'score': 0.95854163}, {'id': 'https://openalex.org/C2779256057', 'wikidata': 'https://www.wikidata.org/wiki/Q16909647', 'display_name': 'Tumor progression', 'level': 3, 'score': 0.69847727}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5850979}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5705524}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.56589556}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.46777788}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.19180533}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.15675992}], 'mesh': [{'descriptor_ui': 'D050976', 'descriptor_name': 'Basic-Leucine Zipper Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D053263', 'descriptor_name': 'Gene Regulatory Networks', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D051778', 'descriptor_name': 'Basic Helix-Loop-Helix Leucine Zipper Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051778', 'descriptor_name': 'Basic Helix-Loop-Helix Leucine Zipper Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051778', 'descriptor_name': 'Basic Helix-Loop-Helix Leucine Zipper Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050976', 'descriptor_name': 'Basic-Leucine Zipper Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050976', 'descriptor_name': 'Basic-Leucine Zipper Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016000', 'descriptor_name': 'Cluster Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0082457', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0082457&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/d750337b2fb64d24ac7cc80b73bb9c9d', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3857773', 'pdf_url': 'https://europepmc.org/articles/pmc3857773?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10183/225326', 'pdf_url': 'https://lume.ufrgs.br/bitstream/10183/225326/1/000915500.pdf', 'source': {'id': 'https://openalex.org/S4306402641', 'display_name': 'LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4383465926', 'host_organization_name': 'LA Referencia', 'host_organization_lineage': ['https://openalex.org/I4383465926'], 'host_organization_lineage_names': ['LA Referencia'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857773', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24349289', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0082457', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0082457&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.88}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 81, 'referenced_works': ['https://openalex.org/W139309820', 'https://openalex.org/W1519958729', 'https://openalex.org/W1552033616', 'https://openalex.org/W1570622790', 'https://openalex.org/W1898299209', 'https://openalex.org/W1951128322', 'https://openalex.org/W195865777', 'https://openalex.org/W1959376412', 'https://openalex.org/W1966955143', 'https://openalex.org/W1968998295', 'https://openalex.org/W1969315337', 'https://openalex.org/W1973186568', 'https://openalex.org/W1983867616', 'https://openalex.org/W1984164498', 'https://openalex.org/W1985200617', 'https://openalex.org/W1985308729', 'https://openalex.org/W1986100580', 'https://openalex.org/W2000215626', 'https://openalex.org/W2014666371', 'https://openalex.org/W2017877824', 'https://openalex.org/W2021536610', 'https://openalex.org/W2022397091', 'https://openalex.org/W2035041551', 'https://openalex.org/W2039181243', 'https://openalex.org/W2041547446', 'https://openalex.org/W2044350730', 'https://openalex.org/W2046661986', 'https://openalex.org/W2047404819', 'https://openalex.org/W2047547891', 'https://openalex.org/W2047614415', 'https://openalex.org/W2048478983', 'https://openalex.org/W2048674295', 'https://openalex.org/W2055562581', 'https://openalex.org/W2061026023', 'https://openalex.org/W2075406901', 'https://openalex.org/W2079901920', 'https://openalex.org/W2081098333', 'https://openalex.org/W2082039282', 'https://openalex.org/W2084620487', 'https://openalex.org/W2085934079', 'https://openalex.org/W2086132387', 'https://openalex.org/W2089067113', 'https://openalex.org/W2095849686', 'https://openalex.org/W2100089498', 'https://openalex.org/W2101039596', 'https://openalex.org/W2103695091', 'https://openalex.org/W2106713259', 'https://openalex.org/W2110265246', 'https://openalex.org/W2110962700', 'https://openalex.org/W2118071133', 'https://openalex.org/W2118862408', 'https://openalex.org/W2120006551', 'https://openalex.org/W2125170852', 'https://openalex.org/W2129296674', 'https://openalex.org/W2129586435', 'https://openalex.org/W2130002311', 'https://openalex.org/W2130926603', 'https://openalex.org/W2136245178', 'https://openalex.org/W2140952049', 'https://openalex.org/W2142318636', 'https://openalex.org/W2142570576', 'https://openalex.org/W2143017330', 'https://openalex.org/W2147575945', 'https://openalex.org/W2149353806', 'https://openalex.org/W2149517362', 'https://openalex.org/W2156543879', 'https://openalex.org/W2157232173', 'https://openalex.org/W2158640653', 'https://openalex.org/W2160014402', 'https://openalex.org/W2160697532', 'https://openalex.org/W2161409973', 'https://openalex.org/W2162371443', 'https://openalex.org/W2164097016', 'https://openalex.org/W2167190345', 'https://openalex.org/W2271226922', 'https://openalex.org/W2320699773', 'https://openalex.org/W2417317929', 'https://openalex.org/W3068960408', 'https://openalex.org/W4211031423', 'https://openalex.org/W4250627081', 'https://openalex.org/W92636149'], 'related_works': ['https://openalex.org/W4387937397', 'https://openalex.org/W4321228505', 'https://openalex.org/W4213330937', 'https://openalex.org/W3025904015', 'https://openalex.org/W2952910607', 'https://openalex.org/W2331058431', 'https://openalex.org/W2040009421', 'https://openalex.org/W2031747930', 'https://openalex.org/W2021744816', 'https://openalex.org/W1974317126'], 'abstract_inverted_index': {'Neuroblastoma': [0], 'is': [1, 20, 32, 189, 209, 251], 'the': [2, 75, 107, 151, 202, 212, 252, 256, 259], 'most': [3], 'common': [4], 'extracranial': [5], 'tumor': [6, 31, 66, 90], 'and': [7, 92, 175, 264], 'a': [8, 224], 'major': [9], 'cause': [10], 'of': [11, 29, 150, 153, 200, 204, 236, 261], 'infant': [12], 'cancer': [13], 'mortality': [14], 'worldwide.': [15], 'Despite': [16], 'its': [17, 23, 33, 123], 'importance,': [18], 'little': [19], 'known': [21], 'about': [22], 'molecular': [24], 'mechanisms.': [25], 'A': [26], 'striking': [27], 'feature': [28], 'this': [30, 70, 250, 262], 'clinical': [34, 142], 'heterogeneity.': [35], 'Possible': [36], 'outcomes': [37], 'range': [38], 'from': [39], 'aggressive': [40, 114], 'invasion': [41], 'to': [42, 48, 64, 85, 121, 139, 247], 'other': [43, 134, 244], 'tissues,': [44], 'causing': [45], 'patient': [46, 166], 'death,': [47], 'spontaneous': [49], 'disease': [50], 'regression': [51], 'or': [52, 100], 'differentiation': [53, 197, 218, 231], 'into': [54], 'benign': [55], 'ganglioneuromas.': [56], 'Several': [57], 'efforts': [58], 'have': [59, 73, 105, 157, 169], 'been': [60, 239], 'made': [61], 'in': [62, 83, 89, 119, 133, 191, 215, 228, 243], 'order': [63, 84, 120], 'find': [65, 86, 122], 'progression': [67, 91], 'markers.': [68], 'In': [69], 'work,': [71], 'we': [72], 'reconstructed': [74, 108], 'neuroblastoma': [76, 109, 115, 135, 154, 181, 192], 'regulatory': [77, 110], 'network': [78, 111], 'using': [79, 112], 'an': [80, 113], 'information-theoretic': [81], 'approach': [82], 'genes': [87], 'involved': [88, 190], 'that': [93, 159, 172, 187, 221, 255], 'could': [94], 'be': [95], 'used': [96], 'as': [97, 101, 138, 148, 241], 'outcome': [98], 'predictors': [99], 'therapeutic': [102], 'targets.': [103], 'We': [104, 156, 168, 185], 'queried': [106], 'metastasis': [116], 'gene': [117, 263], 'signature': [118], 'master': [124], 'regulators': [125], '(MRs).': [126], 'MRs': [127, 152], 'expression': [128, 162, 174, 260], 'profiles': [129], 'were': [130, 178], 'then': [131], 'investigated': [132], 'datasets': [136], 'so': [137], 'detect': [140], 'possible': [141], 'significance.': [143], 'Our': [144], 'analysis': [145], 'pointed': [146], 'MAX': [147, 161, 173, 188, 222, 237], 'one': [149], 'progression.': [155], 'found': [158, 171, 214], 'higher': [160], 'correlated': [163], 'with': [164, 211], 'favorable': [165], 'outcomes.': [167], 'also': [170], 'protein': [176], 'levels': [177], 'increased': [179], 'during': [180], 'SH-SY5Y': [182, 217], 'cells': [183, 230], 'differentiation.': [184], 'propose': [186], 'progression,': [193], 'possibly': [194], 'increasing': [195], 'cell': [196], 'by': [198], 'means': [199], 'regulating': [201], 'availability': [203], 'MYC:MAX': [205], 'heterodimers.': [206], 'This': [207], 'mechanism': [208], 'consistent': [210], 'results': [213], 'our': [216, 248], 'protocol,': [219], 'suggesting': [220], 'has': [223, 238], 'more': [225], 'central': [226], 'role': [227], 'these': [229], 'than': [232], 'previously': [233], 'reported.': [234], 'Overexpression': [235], 'identified': [240], 'anti-tumorigenic': [242], 'works,': [245], 'but,': [246], 'knowledge,': [249], 'first': [253], 'time': [254], 'link': [257], 'between': [258], 'malignancy': [265], 'was': [266], 'verified': [267], 'under': [268], 'physiological': [269], 'conditions.': [270]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2040009421', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-14T08:00:52.448686', 'created_date': '2016-06-24'}