Mycobacterium tuberculosis Reprograms Waves of Phosphatidylinositol 3-Phosphate on Phagosomal Organelles

Name: Work Video:
Duration: 3 min 30 s
Jennifer Chua; Vojo Deretić
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2928, 3087, 3316], 'Mycobacteria': [145, 373], 'alter': [146, 374], 'two': [150, 378, 3429, 4290], 'ways:': [151, 379], '(i)': [152, 380, 994], 'inducing,': [154, 382], 'cholesterol-dependent': [157, 385], 'fashion,': [158, 386], 'neophase': [160, 388], 'I*': [161, 389], 'premature': [163, 391], 'production,': [165, 393], 'coinciding': [166, 394], 'mycobacterial': [171, 399, 1146, 1459, 3635, 3852, 3887, 4050], 'entry': [172, 400, 3565, 3591], 'macrophage,': [175, 403], '(ii)': [177, 405, 1019], 'inhibiting': [179, 407], 'calmodulin-dependent': [181, 409], 'phase': [182, 410], 'II': [183, 411], 'responsible': [184, 412], 'conclude': [192, 420], 'maturation': [199, 427, 742, 914, 1049, 1104, 1356, 1427, 1755, 2027, 4068, 4189], 'includes': [203, 431], 'temporally': [204, 432], 'organized': [205, 433], 'membranes': [212, 440, 1675, 2559, 3625, 3859], 'targeted': [218, 446], 'reprogramming': [220, 448], 'as': [223, 451, 905, 1026, 1762, 1796, 1854, 2520, 2538, 2560, 2641, 3423, 4225], 'they': [224, 452, 901, 4226], 'prevent': [225, 453, 4066], 'formation.': [227, 455], 'Phagocytosis': [456, 1833], 'fundamental': [459], 'biological': [460], 'proper': [464], 'tissue': [465], 'homeostasis,': [466], 'development,': [467], 'elimination': [468], 'invading': [470], 'microorganisms,': [471], 'processing': [473], 'antigens': [475], 'presentation': [477], 'immune': [480], 'system.': [481, 3419], 'Precisely': [482], 'how': [483], 'forms': [486], 'transforms': [488], 'has': [492, 1363, 1417, 2013, 4108], 'been': [493, 903, 1364], 'subject': [495], 'evolving': [497], 'views': [498], '(1Cardelli': [499], 'J.': [500, 524, 600, 627, 648, 671, 705, 790, 828, 836, 841, 954, 1008, 1056, 1114, 1128, 1178, 1198, 1225, 1242, 1269, 1295, 1313, 1346, 1397, 1433, 1438, 1629, 1634, 1687, 1731, 1874, 1919, 1923, 1959, 2039, 2044, 2075, 2089, 2092, 2127, 2158, 2164, 2234, 2264, 2296, 2333, 2364, 2394, 2401, 2431, 2454, 2482, 2503, 2653, 2712, 3225, 3230, 3478, 3490, 3494, 3514, 3675, 3687, 3691, 3711, 3793, 3825, 3830, 3922, 4021, 4026, 4072, 4249], 'Traffic.': [501, 1131, 1807], '2001;': [502, 1441, 1637, 1962, 2047, 2078, 2278, 2434, 3233, 3500, 3697, 3833, 4029], '2:': [503], '311-320Crossref': [504], 'PubMed': [505, 535, 560, 582, 614, 633, 659, 684, 711, 769, 784, 803, 822, 847, 865, 886, 933, 948, 967, 1014, 1040, 1062, 1088, 1120, 1135, 1185, 1213, 1229, 1257, 1273, 1328, 1350, 1408, 1444, 1640, 1700, 1746, 1811, 1880, 1901, 1936, 1965, 2005, 2050, 2081, 2098, 2140, 2168, 2204, 2238, 2281, 2307, 2344, 2377, 2407, 2437, 2469, 2493, 2507, 2670, 2723, 3009, 3236, 3503, 3520, 3539, 3559, 3700, 3717, 3736, 3756, 3836, 3926, 4032, 4087], 'Scopus': [506, 536, 561, 583, 615, 634, 660, 685, 712, 770, 785, 804, 823, 848, 866, 887, 934, 949, 968, 1015, 1041, 1063, 1089, 1121, 1136, 1186, 1214, 1230, 1258, 1274, 1329, 1351, 1409, 1445, 1641, 1701, 1747, 1812, 1881, 1966, 2006, 2051, 2082, 2099, 2141, 2169, 2205, 2239, 2282, 2308, 2345, 2378, 2408, 2438, 2470, 2494, 2508, 2724, 3010, 3237, 3504, 3521, 3540, 3701, 3718, 3737, 3837, 3927, 4033, 4088], '(116)': [507], 'Google': [508, 538, 563, 585, 617, 636, 662, 687, 714, 772, 787, 806, 825, 850, 868, 889, 936, 951, 970, 1017, 1043, 1065, 1091, 1123, 1138, 1188, 1216, 1232, 1260, 1276, 1300, 1331, 1353, 1411, 1447, 1643, 1703, 1749, 1814, 1883, 1902, 1937, 1968, 2008, 2053, 2084, 2101, 2143, 2171, 2207, 2241, 2284, 2310, 2347, 2380, 2410, 2440, 2472, 2496, 2510, 2671, 2726, 3012, 3239, 3485, 3506, 3523, 3542, 3560, 3682, 3703, 3720, 3739, 3757, 3800, 3839, 3929, 4035, 4090, 4256], 'Scholar,': [509, 539, 564, 586, 618, 637, 663, 688, 773, 788, 807, 826, 851, 869, 937, 952, 1124, 1217, 1261, 1277, 1884, 1938, 2054, 2085, 2144, 2285, 2473, 2497, 3486, 3507, 3524, 3543, 3683, 3704, 3721, 3740], '2Jahraus': [510], 'A.': [511, 517, 680, 698, 882, 1209, 1253, 1281, 1324, 1677, 1685, 1742, 1867, 1952, 2068, 2117, 2125, 2289, 2324, 2354, 2362, 2396, 2465, 2475, 2479, 2651, 2753, 4083], 'Tjelle': [512], 'T.E.': [513], 'Berg': [514, 542, 1987], 'T.': [515, 702, 875, 1286, 1871, 1886, 1925, 1948, 2064, 2741], 'Habermann': [516], 'Storrie': [518], 'B.': [519, 760, 924, 2150, 2258], 'Ullrich': [520], 'O.': [521, 598, 754, 918], 'Griffiths': [522, 625], 'G.': [523, 626, 2287], 'Biol.': [525, 556, 575, 629, 649, 707, 765, 929, 1010, 1036, 1058, 1116, 1398, 1440, 1636, 1876, 1892, 1932, 1961, 2001, 2046, 2077, 2200, 2297, 2334, 2403, 2433, 2483, 2665, 2713, 3232, 3481, 3499, 3516, 3535, 3678, 3696, 3713, 3732, 3796, 3832, 4028, 4252], 'Chem.': [526, 650, 1399, 2298, 2335, 2484, 2714], '1998;': [527, 651, 1697, 1933, 2137, 2374, 2404, 2504], '273:': [528, 652], '30379-30390Abstract': [529], 'Full': [530, 532, 579, 609, 611, 654, 656, 1403, 1405, 1896, 1898, 2302, 2304, 2339, 2341, 2488, 2490, 2718, 2720, 3554, 3556, 3751, 3753], 'Text': [531, 533, 580, 610, 612, 655, 657, 1404, 1406, 1897, 1899, 2303, 2305, 2340, 2342, 2489, 2491, 2719, 2721, 3555, 3557, 3752, 3754], 'PDF': [534, 581, 613, 658, 1407, 1900, 2306, 2343, 2492, 2722, 3558, 3755], '(102)': [537], '3Cox': [540], 'D.': [541, 641, 665, 1288, 1388, 1986, 2645, 2661, 2703, 3476, 3488, 3673, 3685, 3791, 4247], 'J.S.': [543, 1988], 'Cammer': [544, 1989], 'M.': [545, 604, 620, 692, 758, 857, 922, 1080, 1360, 1532, 1608, 1693, 1861, 1990, 2133, 2183, 2187, 2197, 2222, 2295, 2370, 2552, 2673, 2752, 2771, 2841, 2888, 3294, 3492, 3526, 3689, 3723, 3816, 3910, 3944], 'Chinegwundoh': [546, 1991], 'J.O.': [547, 1992], 'Dale': [548, 668, 1993], 'B.M.': [549, 669, 1994], 'Cheney': [550, 1995], 'R.E.': [551, 1996], 'Greenberg': [552, 646, 672, 1997], 'S.': [553, 590, 647, 673, 679, 704, 752, 777, 794, 855, 881, 916, 941, 958, 1005, 1162, 1208, 1219, 1252, 1263, 1279, 1283, 1323, 1340, 1435, 1631, 1681, 1741, 1873, 1888, 1890, 1958, 1998, 2041, 2074, 2121, 2146, 2181, 2293, 2358, 2464, 2649, 2663, 3227, 3547, 3744, 3827, 4023, 4082], 'Nat.': [554, 763, 927, 1034, 1999, 2198, 3479, 3497, 3533, 3676, 3694, 3730, 3794, 4250], 'Cell': [555, 574, 628, 706, 764, 842, 928, 1009, 1035, 1057, 1115, 1439, 1635, 1875, 1960, 2000, 2045, 2076, 2199, 2402, 2432, 2580, 3231, 3480, 3498, 3515, 3534, 3677, 3695, 3712, 3731, 3795, 3831, 4027, 4251], '2002;': [557, 606, 819, 1011, 1037, 1059, 1085, 1117, 2002, 3006, 3536, 3733], '4:': [558, 1038, 1133, 1809, 2003, 3537, 3734], '469-477Crossref': [559, 2004], '(178)': [562, 2007], '4Beron': [565], 'W.': [566, 1076], 'Alvarez-Dominguez': [567], 'C.': [568, 592, 832, 834, 838, 1691, 2131, 2160, 2368], 'Mayorga': [569], 'L.': [570, 1944, 2060, 2189, 2659], 'Stahl': [571], 'P.D.': [572], 'Trends': [573], '1995;': [576, 2165], '5:': [577], '100-104Abstract': [578], '(113)': [584], '5Gagnon': [587], 'E.': [588, 594, 756, 830, 920, 2326], 'Duclos': [589], 'Rondeau': [591], 'Chevet': [593], 'Cameron': [595], 'P.H.': [596, 1164], 'Steele-Mortimer': [597, 753, 917], 'Paiement': [599], 'Bergeron': [601], 'J.J.': [602], 'Desjardins': [603, 757, 921], 'Cell.': [605, 1931, 2666, 3550, 3747], '110:': [607], '119-131Abstract': [608], '(561)': [616], '6Desjardins': [619], 'Huber': [621, 1393, 2708], 'L.A.': [622, 1394, 2709], 'Parton': [623, 2229, 3917], 'R.G.': [624, 2230, 3003, 3918], '1994;': [630, 1182, 1297], '124:': [631], '677-688Crossref': [632], '(553)': [635], '7Zhang': [638], 'Q.': [639], 'Cox': [640], 'Tseng': [642], 'C.C.': [643], 'Donaldson': [644], 'J.G.': [645], '19977-19981Abstract': [653], '(173)': [661], '8Cox': [664], 'Lee': [666], 'D.J.': [667, 873, 2218, 3906], 'Calafat': [670], 'Proc.': [674, 876, 1203, 1247, 1318, 1736, 2459, 4077], 'Natl.': [675, 877, 1204, 1248, 1319, 1737, 2460, 4078], 'Acad.': [676, 878, 1205, 1249, 1320, 1738, 2461, 4079], 'Sci.': [677, 843, 879, 1206, 1250, 1321, 1739, 2462, 4080], 'U.': [678, 880, 1207, 1251, 1322, 1740, 2392, 2463, 4081], '2000;': [681, 708, 1877, 2235, 2299, 2336, 3551, 3748, 3923], '97:': [682], '680-685Crossref': [683], '(184)': [686], '9Botelho': [689], 'R.J.': [690, 1390, 1859, 1942, 2058, 2705], 'Teruel': [691, 1860], 'Dierckman': [693, 1862], 'R.': [694, 696, 1679, 1863, 1865, 2119, 2148, 2154, 2224, 2266, 2270, 2356, 2655, 3496, 3693, 3912], 'Anderson': [695, 1864, 3002], 'Wells': [697, 1866], 'York': [699, 1868], 'J.D.': [700, 1869], 'Meyer': [701, 1870], 'Grinstein': [703, 776, 940, 1872, 1957, 2073], '151:': [709, 1878], '1353-1368Crossref': [710, 1879], '(416)': [713, 1882, 1967, 2083], 'Scholar).': [715, 890, 971, 1092, 1139, 1354, 1412, 1644, 1704, 1750, 1815, 2009, 2102, 2242, 2511, 2672, 3013, 3240, 3561, 3801, 3930, 4091], 'Maturation': [716], 'multistage': [725], 'protein': [729], 'sorting': [730], 'process,': [731], 'significant': [734], 'portion': [735], 'current': [738], 'knowledge': [739], 'regarding': [740], 'comes': [743], 'from': [744, 1720, 2448, 2589, 2740, 2751, 2758, 2770, 4294], 'studies': [745, 4172], 'containing': [748, 1791], 'intracellular': [749, 892, 979, 1023, 2314, 3638, 3648], 'pathogens': [750, 893], '(10Meresse': [751, 915], 'Moreno': [755, 919], 'Finlay': [759, 923], 'Gorvel': [761, 925], 'J.P.': [762, 926], '1999;': [766, 930, 1893, 2201, 2485, 3517, 3714], '1:': [767, 931, 2202], 'E183-E188Crossref': [768, 932], '(292)': [771, 935], '11Brumell': [774, 938], 'J.H.': [775, 939], 'Curr.': [778, 797, 942, 961, 1891], 'Opin.': [779, 798, 943, 962], 'Microbiol.': [780, 799, 861, 944, 963], '2004;': [781, 800, 844, 945, 964], '7:': [782, 801, 946, 965], '78-84Crossref': [783, 947], '(97)': [786, 950], '12Chua': [789, 953], 'Vergne': [791, 955, 1199, 1243, 1314, 1732, 2455, 4073], 'I.': [792, 956, 1126, 1200, 1244, 1290, 1315, 1733, 2087, 2456, 3528, 3725, 4074], 'Master': [793, 957], 'Deretic': [795, 959, 1129, 1201, 1245, 1316, 1387, 1395, 1436, 1632, 1734, 2042, 2090, 2457, 2702, 2710, 3228, 3828, 4024, 4075], 'V.': [796, 960, 1130, 1202, 1246, 1317, 1396, 1437, 1633, 1735, 2043, 2091, 2458, 2711, 3229, 3829, 4025, 4076], '71-77Crossref': [802, 966], '(91)': [805, 969, 3505, 3702], '13Nagai': [808], 'H.': [809, 1695, 2135, 2232, 2372, 2481, 2759, 3511, 3708, 3920], 'Kagan': [810, 835], 'J.C.': [811, 1031], 'Zhu': [812], 'X.': [813, 3545, 3742], 'Kahn': [814], 'R.A.': [815, 871, 1196, 1240, 1311, 1429, 1625, 1729, 2035, 2452, 3221, 3821, 4017, 4070], 'Roy': [816, 837, 858, 1032], 'C.R.': [817, 859, 1033, 2430], 'Science.': [818, 1181], '295:': [820], '679-682Crossref': [821], '(442)': [824], '14Guignot': [827], 'Caron': [829], 'Beuzon': [831], 'Bucci': [833], 'Holden': [839], 'D.W.': [840], '117:': [845], '1033-1045Crossref': [846], '(103)': [849], '15Zamboni': [852], 'D.S.': [853], 'McGrath': [854], 'Rabinovitch': [856, 1079], 'Mol.': [860, 1930, 2664], '2003;': [862, 883, 1132, 1210, 1254, 1325, 1743, 1808, 2095, 2466, 2667, 3482, 3679, 3797, 4084, 4253], '49:': [863], '965-976Crossref': [864], '(117)': [867], '16Carabeo': [870], 'Mead': [872], 'Hackstadt': [874], '100:': [884, 1211, 1255, 1326, 1744, 2467, 4085], '6771-6776Crossref': [885], '(213)': [888], 'Because': [891], 'various': [896], 'steps': [897], 'phagolysosomal': [899], 'biogenesis,': [900, 4144], 'have': [902], 'employed': [904, 4154], 'convenient': [906], 'tools': [907], 'dissect': [909], 'different': [910, 4138], 'aspects': [911], 'In': [972, 2512, 3981, 4196], 'general,': [973], 'phagocytosis': [975, 1829, 4123, 4141], 'or': [976, 1067, 1072, 2254, 2938, 2943, 3263, 3293, 3402, 3652, 3943, 3955, 4124, 4288], 'invasion,': [977], 'specializes': [982], 'parasitizing': [984], 'host': [985], 'cells': [986, 2638, 2786, 2814, 2940, 3016, 3052, 3068, 3104, 3126, 3167, 3281, 3338, 3618, 3962, 4107], 'can': [987, 4037], 'follow': [988, 2029], 'one': [989, 2175], 'following': [992, 2960, 4243], 'routes:': [993], 'lysis': [995], 'escape': [1000], 'cytosol': [1003], '(17Dramsi': [1004], 'Cossart': [1006], 'P.': [1007, 1166, 1292, 2332], '156:': [1012], '943-946Crossref': [1013], '(65)': [1016], 'Scholar);': [1018, 1044, 1066], 'unscheduled': [1020], 'fusion': [1021, 2352], 'compartments': [1024, 1074], 'such': [1025, 1761, 1795], 'endoplasmic': [1028], 'reticulum': [1029], '(18Kagan': [1030], '945-954Crossref': [1039], '(354)': [1042], '(iii)': [1045], 'arrest': [1046, 1357], '(19Russell': [1050, 1108], 'D.G.': [1051, 1109, 1180, 1223, 1267, 1294, 1344], 'Mwandumba': [1052, 1110], 'H.C.': [1053, 1111], 'Rhoades': [1054, 1112], 'E.E.': [1055, 1113], '158:': [1060, 1118], '421-426Crossref': [1061, 1119], '(139)': [1064, 1122], '(iv)': [1068], 'survival': [1069], 'lysosome-like': [1071], 'autophagic': [1073], '(20Beron': [1075], 'Gutierrez': [1077], 'M.G.': [1078], 'Colombo': [1081], 'M.I.': [1082], 'Infect.': [1083], 'Immun.': [1084], '70:': [1086, 2279], '5816-5821Crossref': [1087], '(186)': [1090], 'parasitizes': [1095], 'arresting': [1098], '21Vergne': [1125], 'Chua': [1127, 1197, 1241, 1312, 1730, 2088, 2453, 4071], '600-606Crossref': [1134], '(85)': [1137], 'major': [1141], 'defining': [1142], 'features': [1143], 'are': [1148, 1456], 'fewer': [1150], 'H+': [1151, 1716], 'ATPase': [1152, 1717], 'molecules': [1153, 1309], 'attendant': [1156], 'deficit': [1157], 'luminal': [1159], 'acidification': [1160], '(22Sturgill-Koszycki': [1161], 'Schlesinger': [1163], 'Chakraborty': [1165], 'Haddix': [1167], 'P.L.': [1168], 'Collins': [1169], 'H.L.': [1170], 'Fok': [1171], 'A.K.': [1172], 'Allen': [1173, 1291], 'R.D.': [1174], 'Gluck': [1175], 'S.L.': [1176], 'Heuser': [1177], 'Russell': [1179, 1222, 1266, 1293, 1343], '263:': [1183], '678-681Crossref': [1184], '(1052)': [1187], 'Scholar),': [1189, 1301, 1332, 1448, 1903, 1969, 2172, 2208, 2348, 2381, 2411, 2441], 'absence': [1190], 'hydrolases': [1194, 1713], '(23Fratti': [1195, 1239, 1310, 1728, 2451, 4069], '5437-5442Crossref': [1212, 1256, 1327, 1745, 2468, 4086], '(382)': [1215, 1259, 1330, 1748, 2471, 4089], '24Sturgill-Koszycki': [1218, 1262], 'Schaible': [1220, 1264, 1341], 'U.E.': [1221, 1265, 1342], 'EMBO': [1224, 1268, 1345, 2163, 2233, 2502, 3921], '1996;': [1226, 1270, 1347], '15:': [1227, 1271, 1348], '6960-6968Crossref': [1228, 1272, 1349], '(297)': [1231, 1275, 1352], 'Scholar)': [1233, 2311, 3758, 3840, 4036, 4257], 'mannose': [1236], '6-phosphate': [1237], 'receptor': [1238], '25Xu': [1278], 'Cooper': [1280], 'Sturgill-Koszycki': [1282], 'van': [1284], 'Heyningen': [1285], 'Chatterjee': [1287], 'Orme': [1289], 'Immunol.': [1296], '153:': [1298], '2568-2578PubMed': [1299], 'lack': [1302], 'specific': [1304], 'tethering': [1306], 'docking': [1308], 'extended': [1334], 'accessibility': [1335], 'transferrin': [1337], 'receptors': [1338, 2385], '(24Sturgill-Koszycki': [1339], 'linked': [1365], 'block': [1368], 'between': [1369], 'stages': [1371, 2024, 4139], 'controlled': [1372], 'early': [1375, 1466, 1476, 1552, 2349, 3065, 4119, 4183], 'endosomal': [1376, 1382, 1467, 1477, 1553, 2350, 2414, 3066, 3102], 'GTPase': [1377], 'Rab5': [1378, 1423, 1666, 2178], 'its': [1380, 2990, 3863], 'late': [1381, 2388, 3101], 'counterpart': [1383], 'Rab7': [1384], '(26Via': [1385, 2700], 'L.E.': [1386, 2701], 'Ulmer': [1389, 2704], 'Hibler': [1391, 2706], 'N.S.': [1392, 2707], '1997;': [1400, 2715], '272:': [1401, 2716], '13326-13331Abstract': [1402, 2717], '(443)': [1410, 2725], 'A': [1413, 1816], 'recent': [1414], 'follow-up': [1415], 'study': [1416], 'examined': [1418, 3392, 3890], 'possible': [1420], 'roles': [1421], 'effectors': [1424, 2179], '(27Fratti': [1428, 1624, 2034, 3220, 3820, 4016], 'Backer': [1430, 1626, 1928, 1953, 2036, 2069, 2194, 2399, 2427, 3222, 3822, 4018], 'J.M.': [1431, 1627, 1683, 1929, 1954, 2037, 2070, 2123, 2195, 2228, 2360, 2400, 2428, 2477, 3223, 3823, 3916, 4019], 'Gruenberg': [1432, 1628, 2038, 3224, 3824, 4020], 'Corvera': [1434, 1630, 2040, 2662, 3226, 3826, 4022], '154:': [1442, 1638, 2048, 3234, 3834, 4030], '631-644Crossref': [1443, 1639, 2049, 3235, 3835, 4031], '(413)': [1446, 1642, 2052, 3238, 3838, 4034], 'indicating': [1449], 'majority': [1452], 'Rab5-interacting': [1454], 'partners': [1455], 'present': [1457], 'exception': [1463], 'autoantigen': [1468, 1478, 1554], '1': [1469, 3027, 3132, 3622], '(EEA1)': [1470], '1The': [1471], 'abbreviations': [1472, 1548], 'used': [1473, 1549, 3783], 'are:': [1474, 1550], 'EEA1,': [1475, 1551, 1763], '1;': [1479, 1555], 'PI3P,': [1480, 1556, 2012], '3-phosphate;': [1482, 1558], 'PI4P,': [1483, 1559], '4-phosphate;': [1485, 1561], 'TGN,': [1486, 1562], 'trans-Golgi': [1487, 1563, 1722], 'network;': [1488, 1564], 'PI,': [1489, 1565], 'phosphatidylinositol;': [1490, 1566], 'PIP2,': [1491, 1567], '4,5-bisphosphate;': [1493, 1569], 'PIP3,': [1494, 1570], '3,4,5-trisphosphate;': [1496, 1572], 'PI3K,': [1497, 1573], '3-kinase;': [1499, 1575], 'DME,': [1500, 1576], "Dulbecco's": [1501, 1577], 'modified': [1502, 1578], "Eagle's": [1503, 1579], 'medium;': [1504, 1580], 'FBS,': [1505, 1581, 2605], 'fetal': [1506, 1582], 'bovine': [1507, 1583], 'serum;': [1508, 1584], 'BCG,': [1509, 1585], 'bacillus': [1510, 1586], 'Calmette-Guérin;': [1511, 1587], 'EGFP,': [1512, 1588], 'enhanced': [1513, 1589], 'green': [1514, 1590, 3276], 'fluorescence': [1515, 1591], 'protein;': [1516, 1592], 'PBS,': [1517, 1593, 3077], 'phosphate-buffered': [1518, 1594], 'saline;': [1519, 1595], 'CaM,': [1520, 1596], 'calmodulin;': [1521, 1597], 'CaMKII,': [1522, 1598], 'calmodulin': [1523, 1599], 'kinase': [1524, 1600], 'II;': [1525, 1601], 'MβCD,': [1526, 1602], 'methyl-β-cyclodextrin;': [1527, 1603], 'GST,': [1528, 1604], 'glutathione': [1529, 1605], 'S-transferase;': [1530, 1606], 'MBP,': [1531, 1607], 'phagosome;': [1534, 1538, 1610, 1614], 'LBP,': [1535, 1611], 'latex': [1536, 1612, 2977, 3119, 3143, 3291, 3567, 3880, 3941], 'bead': [1537, 1613, 3633, 3881], 'W7,': [1539, 1615, 2946], 'naphthalene': [1541, 1617], 'sulforamide': [1542, 1618], 'CaM': [1543, 1619], 'inhibitor;': [1544, 1620], 'FAPP,': [1545, 1621], 'four-phosphate-adaptor': [1546, 1622], 'protein.1The': [1547], 'protein.': [1623], 'EEA1': [1645, 1705, 3813, 3855, 4012], 'membrane-tethering': [1648], 'molecule': [1649], 'recruited': [1652], 'surfaces': [1655], 'via': [1656], 'bipartite': [1658], 'mechanism,': [1659], 'comprises': [1661], 'binding': [1663, 1793], 'association': [1668, 3861, 3986], '(PI3P)': [1672], 'target': [1674, 3858], '(28Simonsen': [1676, 2116, 2353], 'Lippe': [1678, 2118, 2355], 'Christoforidis': [1680, 2120, 2357], 'Gaullier': [1682, 2122, 2227, 2359, 2476, 3915], 'Brech': [1684, 2124, 2361], 'Callaghan': [1686, 2126, 2363], 'Toh': [1688, 2128, 2365], 'B.H.': [1689, 2129, 2366], 'Murphy': [1690, 2130, 2367], 'Zerial': [1692, 2132, 2196, 2369], 'Stenmark': [1694, 2134, 2231, 2371, 2480, 2760, 3919], 'Nature.': [1696, 2136, 2373], '394:': [1698, 2138, 2375], '494-498Crossref': [1699, 2139, 2376], '(902)': [1702, 2142, 2379], 'required': [1707], 'PI3P-dependent': [1710], 'delivery': [1711], 'Vo': [1718], 'subunit': [1719], 'network': [1723], '(TGN)': [1724], 'role': [1752, 1827], 'phosphoinositide-interacting': [1757], 'regulators': [1758], 'trafficking,': [1760], 'underscores': [1764], 'significance': [1766, 2572], '(PI)': [1769], 'derivatives': [1770, 1777, 1820], 'PI': [1776, 1819], 'regulate': [1778], 'diverse': [1779], 'processes': [1781], 'affecting': [1783], 'localization': [1785, 2245, 3639], 'activity': [1787], 'effector': [1789], 'proteins': [1790, 1823, 2249], 'modules': [1794], 'C2,': [1797], 'ENTH,': [1798], 'FERM,': [1799], 'FYVE,': [1800, 2252], 'PH,': [1801, 2253], 'PX': [1803, 2255, 4285], 'domains': [1804, 2256, 4293], '(29Lemmon': [1805], 'M.A.': [1806, 2291], '201-213Crossref': [1810], '(479)': [1813], 'subset': [1817, 2444], 'lipid-binding': [1822], 'also': [1824], 'plays': [1825], 'triggers': [1834], 'production': [1835], '4,5-bisphosphate': [1838], '(PIP2),': [1839], 'recruits': [1841], 'actin': [1842], 'phagocytic': [1845, 4184], 'cup;': [1846], 'followed': [1849, 3134, 3159, 3178, 3467, 3579, 3607, 3952], 'disappearance': [1851], 'PIP2': [1853, 1913], 'seals': [1857], '(9Botelho': [1858], '30Matsui': [1885], 'Yonemura': [1887], 'Tsukita': [1889], '9:': [1894], '1259-1262Abstract': [1895], 'concomitant': [1904], 'activation': [1906], 'phospholipase': [1908], 'C': [1909], 'conversion': [1911, 2566], '3,4,5-trisphosphate': [1916], '(PIP3)': [1917], '(31Yu': [1918], 'Zhang': [1920, 2397], 'Y.': [1921, 2398], 'McIlroy': [1922, 2393], 'Rordorf-Nikolic': [1924], 'Orr': [1926], 'G.A.': [1927], '18:': [1934], '1379-1387Crossref': [1935], '32Vieira': [1939, 2055], 'O.V.': [1940, 2056], 'Botelho': [1941, 2057], 'Rameh': [1943, 2059], 'Brachmann': [1945, 2061], 'S.M.': [1946, 2062], 'Matsuo': [1947, 2063], 'Davidson': [1949, 2065], 'H.W.': [1950, 2066], 'Schreiber': [1951, 2067], 'Cantley': [1955, 2071], 'L.C.': [1956, 2072], '155:': [1963, 2079, 2435], '19-25Crossref': [1964, 2080], 'latter': [1971], 'being': [1972], 'necessary': [1973], 'Myosin': [1976], 'X-dependent': [1977], 'extension': [1978], 'pseudopods': [1980], 'around': [1981], 'ingested': [1983], 'particle': [1984, 2032], '(3Cox': [1985], 'Another': [2010], 'phosphoinositide,': [2011], 'recently': [2014], 'received': [2015], 'more': [2016], 'attention,': [2017], 'because': [2018, 3854], 'it': [2019, 2536], 'important': [2021], 'those': [2023, 3885], 'uptake': [2033], '33Vergne': [2086], 'Exp.': [2093], 'Med.': [2094], '198:': [2096], '653-659Crossref': [2097], '(260)': [2100], 'product': [2106], '3-kinase': [2110, 4064], '(PI3K)': [2111], 'hVPS34': [2112], '(in': [2113], 'yeast,': [2114], 'Vps34p)': [2115], '34Volinia': [2145], 'Dhand': [2147], 'Vanhaesebroeck': [2149], 'MacDougall': [2151], 'L.K.': [2152], 'Stein': [2153], 'Zvelebil': [2155], 'M.J.': [2156], 'Domin': [2157], 'Panaretou': [2159], 'Waterfield': [2161, 2192, 2273], 'M.D.': [2162, 2193, 2274], '14:': [2166, 2668], '3339-3348Crossref': [2167], '(305)': [2170], '(35Christoforidis': [2180], 'Miaczynska': [2182], 'Ashman': [2184], 'K.': [2185, 2262, 2657], 'Wilm': [2186], 'Zhao': [2188], 'Yip': [2190], 'S.C.': [2191], '249-252Crossref': [2203], '(495)': [2206], 'thought': [2211], 'localize': [2213], 'predominantly': [2214], 'endomembranes': [2216, 2528], '(36Gillooly': [2217, 3905], 'Morrow': [2219, 3907], 'I.C.': [2220, 3908], 'Lindsay': [2221, 3909], 'Gould': [2223, 3911], 'Bryant': [2225, 3913], 'N.J.': [2226, 3914], '19:': [2236, 3924], '4577-4588Crossref': [2237, 3925], '(837)': [2240, 3928], 'affects': [2244], 'function': [2247], 'contain': [2251], '(37Vanhaesebroeck': [2257], 'Leevers': [2259], 'S.J.': [2260], 'Ahmadi': [2261], 'Timms': [2263], 'Katso': [2265], 'Driscoll': [2267], 'P.C.': [2268], 'Woscholski': [2269], 'Parker': [2271], 'P.J.': [2272], 'Annu.': [2275], 'Rev.': [2276], 'Biochem.': [2277], '535-602Crossref': [2280], '(1347)': [2283], '38Razzini': [2286], 'Brancaccio': [2288], 'Lemmon': [2290], 'Guarnieri': [2292], 'Falasca': [2294], '275:': [2300, 2337], '14873-14881Abstract': [2301], '(59)': [2309], 'controls': [2313], 'signal': [2317], 'transduction.': [2318], 'Such': [2319], 'functions': [2320, 2537], 'include': [2321], 'autophagy': [2322], '(39Petiot': [2323], 'Ogier-Denis': [2325], 'Blommaart': [2327], 'E.F.': [2328], 'Meijer': [2329], 'A.J.': [2330], 'Codogno': [2331], '992-998Abstract': [2338], '(1021)': [2346], 'homotypic': [2351], 'transit': [2382], 'internalized': [2384], 'endocytic': [2389], 'compartment': [2390], '(40Siddhanta': [2391], 'Shah': [2395], '143:': [2405], '1647-1659Crossref': [2406], '(137)': [2409], 'formation': [2412, 2526], 'multivesicular': [2415], 'bodies': [2416], 'involved': [2417], 'termination': [2419], 'signaling': [2421], 'events': [2422, 4126, 4185], '(41Futter': [2423], 'C.E.': [2424], 'Collinson': [2425], 'L.M.': [2426], 'Hopkins': [2429], '1251-1264Crossref': [2436], '(200)': [2439], 'transport': [2446], 'pathways': [2447], 'TGN': [2450], '42Simonsen': [2474], "D'Arrigo": [2478], '274:': [2486], '28857-28860Abstract': [2487], '(188)': [2495], '43Wurmser': [2498], 'A.E.': [2499], 'Emr': [2500], 'S.D.': [2501], '17:': [2505], '4930-4942Crossref': [2506], '(127)': [2509], 'work,': [2514], 'show,': [2516], 'system,': [2523], 'not': [2530, 3653], 'uniform': [2532], 'event': [2533], 'timer': [2540], 'programmed': [2543], 'furthermore': [2549], 'reprograms': [2554], 'strategy': [2562], 'blocking': [2564], 'phagolysosome,': [2569], 'underscoring': [2570], 'cycling': [2576], 'organellar': [2578, 3871], 'membranes.': [2579, 3872], 'Bacterial': [2582], 'Culture—Murine': [2583], 'bone': [2584, 3932], 'marrow-derived': [2585, 3147, 3933], 'were': [2587, 2639, 2739, 2787, 2806, 2815, 2848, 2871, 2893, 2913, 3017, 3035, 3053, 3069, 3089, 3105, 3127, 3154, 3168, 3198, 3287, 3318, 3342, 3380, 3391, 3412, 3421, 3640, 3774, 3782, 3935, 3963, 3973, 3995, 4205, 4241, 4274], 'isolated': [2588], 'femurs': [2591], 'C57/BL6': [2593], 'mice': [2594], 'maintained': [2596, 2626], 'DME': [2598, 2628, 3322], 'supplemented': [2599, 2629], '4': [2601, 2631], 'mm': [2602, 2632, 2852, 3021], 'l-glutamine,': [2603], '20%': [2604], 'macrophage-colony': [2607], 'stimulating': [2608], 'factor': [2609], '7': [2611], 'days': [2612], 'prior': [2613, 2830, 2972, 3029, 3094], 'plating': [2615], 'onto': [2616, 3306], 'coverslips.': [2617], 'murine': [2619, 3998], 'macrophage-like': [2620], 'cell': [2621, 2695, 3244, 4000, 4204], 'line': [2622], 'RAW': [2623, 2784, 2936, 3014, 3050, 3279, 4271], '264.7': [2624, 2785, 2937, 3015, 3051, 3280, 4272], 'was': [2625, 2680, 2932, 2949, 2958, 2963, 2970, 2987, 2992, 3190, 3213, 3247, 3300, 3572, 3592, 4153], 'l-glutamine': [2633], '10%': [2635], 'FBS.': [2636], 'COS-7': [2637, 2939], 'grown': [2640, 2681, 3149, 3282], 'described': [2642], 'previously': [2643, 3469, 3669, 3809, 4007], '(44Lawe': [2644], 'Sitouah': [2646], 'N.': [2647], 'Hayes': [2648], 'Chawla': [2650], 'Virbasius': [2652], 'Tuft': [2654], 'Fogarty': [2656], 'Lifshitz': [2658], 'Lambright': [2660], '2935-2945Crossref': [2669], 'var.': [2675, 2843, 2890, 3296, 3946], 'bovis': [2676, 2844, 2891, 3297, 3947], 'BCG': [2677, 2892, 3948], 'harboring': [2678], 'phsp60-DsRed': [2679], '7H9': [2683], 'broth': [2684], 'rotating': [2687, 3251, 4166], 'platform': [2688], 'homogenized': [2690], 'generate': [2692], 'single': [2694, 3407, 4233, 4260], 'suspension': [2696], '(Via': [2697], 'et': [2698], 'al.': [2699], 'Scholar)).': [2727], 'Plasmid': [2728], 'Constructs': [2729], 'Transfection—The': [2731], 'plasmid': [2732, 2803], 'constructs': [2733], 'pPLC∂': [2734], 'PH-EGFP': [2735, 2738, 2750], 'pBtk': [2737], 'Balla': [2742], '(National': [2743], 'Institutes': [2744], 'Health,': [2746], 'Bethesda,': [2747], 'MD),': [2748], 'pFAPP': [2749], 'De': [2754], 'Matteis': [2755], '(Italy),': [2756], 'p2xFYVE-EGFP': [2757], '(The': [2761], 'Norwegian': [2762], 'Radium': [2763], 'Hospital,': [2764], 'Oslo,': [2765], 'Norway),': [2766], 'p40phox': [2768, 4284], 'PX-EGFP': [2769], 'Yaffe': [2772], '(Massachusetts': [2773], 'Institute': [2774], 'Technology,': [2776], 'Cambridge,': [2777], 'MA).': [2778], 'For': [2779, 3064, 3100, 3121, 4236], 'transfection,': [2780], '5': [2781, 2861, 2902, 3086, 3112, 3315], '×': [2782], '106': [2783], 'resuspended': [2788], 'nucleoporator': [2791], 'buffer': [2792], 'supplied': [2793], 'manufacturer': [2796], '(Amaxa': [2797], 'Biosystems)': [2798], '2': [2800], 'μg': [2801], 'DNA.': [2804], 'Cells': [2805, 3034, 3088], 'nucleoporated': [2807, 4275], 'according': [2808], "manufacturer's": [2811], 'protocol.': [2812], 'plated': [2816], '25-mm': [2818, 3151, 3284], 'diameter': [2819], 'coverslips': [2820, 3153, 3286, 3310], 'allowed': [2822, 3288, 3936, 4177, 4220], 'express': [2824], 'construct': [2826], '18': [2828], 'h': [2829, 3028], 'imaging': [2832, 4162], 'experiments.': [2833], 'Preparation': [2834], 'Texas': [2836, 2863, 2904, 3058, 3083, 3109], 'Red-labeled': [2837], 'Latex': [2838, 3632], 'Beads': [2839, 2870], 'BCG—Streptavidin-conjugated': [2845], 'polystyrene': [2846], 'beads': [2847, 2978, 3292, 3568, 3942], 'washed': [2849, 2873, 2894, 2914, 3074, 3090], '50': [2851], 'NaHCO3,': [2853], 'pH': [2854], '9.6,': [2855], 'incubated': [2857, 2900, 3018, 3054, 3081, 3107, 3169], 'PBS': [2859, 2876, 2907, 2917, 3093], 'mg/ml': [2862, 2903, 3057], 'Red-X': [2864, 2905], '(Molecular': [2865, 3186], 'Probes)': [2866], '1-2': [2868, 2909], 'h.': [2869, 2910], 'subsequently': [2872, 3080], '(5×)': [2874, 2915], 'then': [2878, 2919, 3079, 3116, 3140], 'opsonized': [2879, 2920], '100%': [2881, 2922], 'FBS': [2882, 2923], 'additional': [2885, 2926], '30': [2886, 2927], 'PBS/0.5%': [2896], 'Tween': [2897], 'Labeled': [2911], 'Treatment': [2929], 'Inhibitors—CaM': [2931], 'inhibited': [2933, 2964], 'treating': [2935], '25': [2942], '100': [2944], 'μm': [2945, 3379], 'respectively.': [2947], 'W7': [2948], 'added': [2950, 2971], 'after': [2951, 3959], 'first': [2953, 3070, 3106], 'I)': [2957], 'ascertained': [2959], 'phagocytosis.': [2961], 'CaMKII': [2962], 'KN62': [2966, 2969], '(2': [2967], 'μm).': [2968], 'macrophage': [2974, 3605, 3613, 3999], 'infection': [2975, 3031, 3040], 'throughout': [2980], 'duration': [2982], 'experiment.': [2985], 'Cholesterol': [2986], 'extracted,': [2988], 'removal': [2991], 'verified': [2993], 'methyl-β-cyclodextrin': [2997], '(MβCD)': [2998], 'method': [2999], '(45Smart': [3000], 'E.J.': [3001], 'Methods': [3004], 'Enzymol.': [3005], '353:': [3007], '131-139Crossref': [3008], '(111)': [3011], '10': [3020, 3950], 'MβCD': [3022, 3038], 'serum-free': [3024], 'media': [3025], 'BCG.': [3033, 3298], 'kept': [3036], 'during': [3039, 3584], 'imaging.': [3043], 'Labeling': [3044], 'Fluid': [3046], 'Phase': [3047], 'Endocytic': [3048], 'Tracers—Transfected': [3049], '2.5': [3056], 'Red-dextran': [3059, 3084, 3110], '(Mr': [3060], '10,000,': [3061], 'Molecular': [3062], 'Probes).': [3063, 3187], 'labeling,': [3067, 3103], 'infected': [3071, 3117, 3141], 'particles,': [3073], '(3×)': [3075], '(6×)': [3091], 'viewing': [3096], 'under': [3097], 'microscope.': [3099, 3196, 4170], 'min,': [3113], 'washed,': [3114], 'beads.': [3120, 3144], 'labeling': [3122], 'compartments,': [3125], 'pulsed': [3128], 'dextran': [3130], 'h,': [3133], '2-h': [3137], 'chase,': [3138], 'Immunofluorescence': [3145], 'Microscopy—Bone': [3146], 'glass': [3152, 3285], 'fixed': [3155, 3964, 4106], '1%': [3157], 'paraformaldehyde': [3158], 'permeabilization': [3162], '0.2%': [3164], 'saponin.': [3165], 'Permeabilized': [3166], 'probe': [3172, 3210, 3903, 3978, 3990], '2xFYVE-GST': [3173], '(10': [3174], 'μg/ml,': [3175], 'Echelon,': [3176], 'Inc.)': [3177], 'anti-GST': [3180], 'antibody': [3181], 'conjugated': [3182], 'Alexa': [3184], '488': [3185], 'Epifluorescence': [3188], 'microscopy': [3189, 3246, 3474, 3893, 4149], 'performed': [3191, 3248], 'IX70': [3194], 'Olympus': [3195], 'Images': [3197, 3411], 'collected': [3199, 3413, 3422], 'processed': [3201, 3415, 3434, 3966], 'LSR': [3203], 'Esprit': [3204], 'software.': [3205], 'Colocalization': [3206], 'determined': [3214], 'methods': [3216], 'unbiased': [3218], 'counting': [3219], 'Four-dimensional': [3241, 3665, 4092], 'Confocal': [3242, 3666], 'Microscopy—Live': [3243], 'confocal': [3245, 3253, 3371, 4169], 'disc': [3252], 'UltraView': [3254, 3418, 3772, 4168, 4175], 'LCI': [3255], 'microscope': [3256], 'system': [3257, 4176], '(PerkinElmer': [3258], 'Life': [3259], 'Sciences)': [3260], 'argon': [3262], 'argon/krypton': [3264], 'lasers': [3265], 'appropriate': [3267], 'excitation': [3268], 'dichroic': [3269], 'emission': [3271], 'filters': [3272], 'red': [3274], 'fluorescence.': [3277], 'Transfected': [3278, 3337], 'phagocytose': [3290, 3938], 'Infection': [3299], 'achieved': [3301], 'centrifugation': [3303], 'particles': [3305, 3352, 3390], 'adherent': [3308], 'at': [3311, 3330, 4039, 4127, 4207], '800': [3312], 'rpm': [3313], 'Coverslips': [3317], 'transferred': [3319], 'immediately': [3320], 'perfusion': [3325], 'chamber': [3326], '(Harvard': [3327], 'Apparatus)': [3328], 'set': [3329], 'constant': [3332], 'temperature': [3333], '37': [3335], '°C.': [3336], 'chosen': [3339], 'observation': [3341], 'selected': [3343], 'based': [3344], 'presence': [3347], 'moving': [3349], '(Brownian': [3350], 'motion)': [3351], 'phagocytosed': [3355, 3389], 'adjacent': [3357], 'macrophages.': [3358], 'Rapid': [3359], 'z-stack': [3360], '(controlled': [3361], 'piezoelectric': [3365], 'device;': [3366], 'millisecond': [3367, 4208], 'speed': [3368], 'range)': [3369], 'sections': [3372], 'spanning': [3373], 'total': [3375], 'thickness': [3376, 4201], '10-15': [3378], 'taken': [3381], 'ensure': [3383], 'all': [3385], 'sides': [3386], 'each': [3394, 4211], 'time': [3395, 3425, 4120, 4212], 'point': [3396, 4213], 'regardless': [3397], 'object': [3399], 'movement': [3400, 3583, 3611], 'out': [3403, 4230], 'any': [3405, 4128], 'given': [3406], 'plane': [3408, 3441, 3768], 'focus.': [3410], 'Data': [3420], 'lapse': [3426], 'sequence': [3427, 3461], 'separate': [3430], 'channel/color': [3431], 'z-stacks': [3432], 'three-dimensional': [3436, 3588, 3761, 4221], 'rendering': [3437, 3452, 3785], '(particle': [3438], 'internalization),': [3439], 'x-y': [3440, 3767], 'projection': [3442], 'range': [3445], 'z': [3447], 'stacks': [3448], '(maximum': [3449], 'intensity': [3450, 3777], 'mean-intensity': [3454, 3780], 'quantitative': [3456, 3787], 'analysis),': [3457], 'time-lapse': [3460], 'supplemental': [3463], 'movies.': [3464], 'All': [3465], 'procedures': [3466, 4245], 'published': [3470, 3670, 4244], 'approaches': [3471, 3671], '(46Gerlich': [3475, 3672, 3790, 4246], 'Ellenberg': [3477, 3493, 3674, 3690, 3792, 4248], ':': [3483, 3680, 3798, 4254], 'S14-S19PubMed': [3484, 3681, 3799, 4255], '47Gerlich': [3487, 3684], 'Beaudouin': [3489, 3686], 'Gebhard': [3491, 3688], 'Eils': [3495, 3692], '3:': [3501, 3698], '852-855Crossref': [3502, 3699], '48Manders': [3508, 3705], 'E.M.': [3509, 3706], 'Kimura': [3510, 3707], 'Cook': [3512, 3709], 'P.R.': [3513, 3710], '144:': [3518, 3715], '813-821Crossref': [3519, 3716], '(150)': [3522, 3719], '49Platani': [3525, 3722], 'Goldberg': [3527, 3724], 'Lamond': [3529, 3726], 'A.I.': [3530, 3727], 'Swedlow': [3531, 3728], 'J.R.': [3532, 3729], '502-508Crossref': [3538, 3735], '(226)': [3541, 3738], '50He': [3544, 3741], 'Asthana': [3546, 3743], 'Sorger': [3548, 3745], 'P.K.': [3549, 3746], '101:': [3552, 3749], '763-775Abstract': [3553, 3750], 'Particle': [3562], 'Entry': [3563], 'Determination—The': [3564], 'identified': [3573, 3593], 'characteristic': [3576], 'brief': [3577], 'immobilization,': [3578], 'centripetal': [3582], 'internalization': [3585, 3636], '(confirmed': [3586], 'reconstruction).': [3589], 'Mycobacterial': [3590, 3807], 'immobilization': [3595], 'bacilli': [3598], 'their': [3600], 'firm': [3601], 'attachment': [3602], 'surface,': [3606], 'centrifugal': [3610], 'along': [3615], 'bacterial': [3617], '(see': [3619, 4214], 'Supplemental': [3620], 'Movie': [3621], 'showing': [3623], 'PIP2-labeled': [3624], 'engulfing': [3630], 'mycobacteria).': [3631], 'additionally': [3641], 'confirmed': [3642], 'differentially': [3644], 'staining': [3645, 3896], 'extracellular': [3646], 'objects': [3649, 4224], '(by': [3650], 'permeabilizing': [3651, 3654], 'plasma': [3656], 'membrane)': [3657], 'independent': [3659], 'correlative': [3660], 'studies.': [3661], 'Quantitative': [3662], 'Analysis': [3663, 4095], 'Microscopy': [3667, 4094], 'Data—The': [3668], 'analyzing': [3760], 'data': [3762], 'projections': [3764, 3778, 3781], 'built': [3769], 'software': [3773], 'applied.': [3775], 'Maximum': [3776], 'analysis,': [3788], 'respectively': [3789], 'Diminished': [3802], 'Levels': [3803], 'Phagosomes—The': [3808], 'reported': [3810, 4008], 'changes': [3811], 'recruitment': [3814, 4013], '(MBPs)': [3819], 'led': [3841], 'us': [3842], 'hypothesize': [3844], 'profiles': [3847], 'may': [3848], 'affected': [3850], 'binds': [3856], 'through': [3860], 'PI3P-binding': [3864], 'FYVE': [3865, 4292], 'domain': [3866, 4286], 'To': [3873, 4131], 'compare': [3874], 'levels': [3877, 4046], 'model,': [3879], '(LBPs)': [3883], 'immunofluorescence': [3892], 'affinity': [3902], '(2xFYVE-GST)': [3904], 'Murine': [3931], 'complement-opsonized': [3939], '1-μm': [3940], 'min': [3951], '20-': [3954], '60-min': [3956], 'chase': [3957], 'periods,': [3958], 'immunostaining.': [3968], 'Under': [3969], 'these': [3970], 'conditions,': [3971], 'LBPs': [3972], 'positive': [3974], '(Fig.': [3979, 3991], '1).': [3980, 3992], 'contrast,': [3982], 'MBPs': [3983, 4015], 'displayed': [3984], 'reduced': [3985], 'Identical': [3993], 'results': [3994], 'obtained': [3996, 4206], 'lines': [4001], 'J774': [4002], 'RAW264.7.': [4004], 'Thus,': [4005], 'phenomenon': [4009], 'altered': [4011, 4045], 'be,': [4038], 'least': [4040], 'part,': [4042], 'explained': [4043], 'This': [4052, 4219], 'keeping': [4055], 'our': [4057], 'earlier': [4058], 'demonstration': [4059], 'treatments': [4061], 'inhibitors': [4065], 'Live': [4093], 'Dynamics:': [4098], 'Multiple': [4099], 'Waves': [4100], 'Phagosomes—Immunostaining': [4104], 'technical': [4109], 'limitations': [4110], 'precluding': [4112], 'reliable': [4114], 'investigation': [4115], 'very': [4118, 4182], 'points': [4121], 'transient': [4125], 'other': [4129], 'stage.': [4130], 'examine': [4132], 'time-resolved': [4135], 'manner': [4136], 'resorted': [4146], 'live': [4148], 'observations.': [4150], 'An': [4151], 'approach': [4152], 'afforded': [4156], 'low': [4157, 4160], 'photocytotoxicity': [4158], 'photobleaching': [4161], 'disk': [4167], 'Time-lapse': [4171], 'monitoring': [4178], 'both': [4180], 'progression': [4190], 'over': [4191, 4269], 'long': [4192], 'periods': [4193], 'time.': [4195, 4270], 'addition,': [4197], 'z-sections': [4198, 4240], 'encompassing': [4199], 'complete': [4200], 'speeds': [4209], '"Experimental': [4215], 'Procedures"': [4216], 'details).': [4218], 'tracking': [4222], 'moved': [4227], 'focal': [4234], 'plane.': [4235], 'analysis': [4237], 'presentation,': [4239], 'collapsed': [4242], 'image': [4261], '(projection),': [4262], 'affording': [4263], 'investigations': [4265], 'volume': [4268], 'DNA': [4277], 'encoding': [4278], 'GFP': [4279], 'fused': [4280], 'either': [4282], '(P40PXEGFP)': [4287], 'tandem': [4291]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2039181024', 'counts_by_year': [{'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2025-01-11T11:36:28.308247', 'created_date': '2016-06-24'}
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