Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2038514347', 'doi': 'https://doi.org/10.1016/0014-5793(81)81227-6', 'title': 'Effect of Ca<sup>2+</sup> on the inhibition of calcium‐activated neutral protease by leupeptin, antipain and epoxysuccinate derivatives', 'display_name': 'Effect of Ca<sup>2+</sup> on the inhibition of calcium‐activated neutral protease by leupeptin, antipain and epoxysuccinate derivatives', 'publication_year': 1981, 'publication_date': '1981-12-21', 'ids': {'openalex': 'https://openalex.org/W2038514347', 'doi': 'https://doi.org/10.1016/0014-5793(81)81227-6', 'mag': '2038514347', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6274695'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/0014-5793(81)81227-6', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2881%2981227-6', 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2881%2981227-6', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5077483738', 'display_name': 'Koichi Suzuki', 'orcid': 'https://orcid.org/0000-0001-8659-4660'}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Koichi Suzuki', 'raw_affiliation_strings': ['Department of Biochemistry, Faculty of Medicine, University of Tokyo, Bunkyo-ku Tokyo 113, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Faculty of Medicine, University of Tokyo, Bunkyo-ku Tokyo 113, Japan', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102080272', 'display_name': 'Shuichi Tsuji', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Shuichi Tsuji', 'raw_affiliation_strings': ['Department of Biochemistry, Faculty of Medicine, University of Tokyo, Bunkyo-ku Tokyo 113, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Faculty of Medicine, University of Tokyo, Bunkyo-ku Tokyo 113, Japan', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5003315468', 'display_name': 'Shoichi Ishiura', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210103779', 'display_name': 'National Center of Neurology and Psychiatry', 'ror': 'https://ror.org/0254bmq54', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103779']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Ishiura Shoichi', 'raw_affiliation_strings': ['Division of Neuromuscular Research, National Center for Nervous, Mental and Muscular Disorders, Kodaira, Tokyo 187, Japan'], 'affiliations': [{'raw_affiliation_string': 'Division of Neuromuscular Research, National Center for Nervous, Mental and Muscular Disorders, Kodaira, Tokyo 187, Japan', 'institution_ids': ['https://openalex.org/I4210103779']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3610, 'currency': 'USD', 'value_usd': 3610, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.829, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 47, 'citation_normalized_percentile': {'value': 0.850082, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '136', 'issue': '1', 'first_page': '119', 'last_page': '122'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T13637', 'display_name': 'Calpain Protease Function and Regulation', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T13637', 'display_name': 'Calpain Protease Function and Regulation', 'score': 0.9915, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11385', 'display_name': 'Natural product bioactivities and synthesis', 'score': 0.989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13326', 'display_name': 'Biochemical and Structural Characterization', 'score': 0.9843, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/antipain', 'display_name': 'Antipain', 'score': 0.6152172}], 'concepts': [{'id': 'https://openalex.org/C2775883766', 'wikidata': 'https://www.wikidata.org/wiki/Q11350119', 'display_name': 'Leupeptin', 'level': 4, 'score': 0.6676921}, {'id': 'https://openalex.org/C2781378782', 'wikidata': 'https://www.wikidata.org/wiki/Q96372211', 'display_name': 'Antipain', 'level': 5, 'score': 0.6152172}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3919331}, {'id': 'https://openalex.org/C161191863', 'wikidata': 'https://www.wikidata.org/wiki/Q199655', 'display_name': 'Library science', 'level': 1, 'score': 0.38396722}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2605467}, {'id': 'https://openalex.org/C2776714187', 'wikidata': 'https://www.wikidata.org/wiki/Q212410', 'display_name': 'Protease', 'level': 3, 'score': 0.25622702}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.16483101}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.11223477}], 'mesh': [{'descriptor_ui': 'D000976', 'descriptor_name': 'Antipain', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D007930', 'descriptor_name': 'Leucine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D007976', 'descriptor_name': 'Leupeptins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009842', 'descriptor_name': 'Oligopeptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000976', 'descriptor_name': 'Antipain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002154', 'descriptor_name': 'Calpain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002413', 'descriptor_name': 'Cations, Divalent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002645', 'descriptor_name': 'Chickens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007461', 'descriptor_name': 'Iodoacetates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007461', 'descriptor_name': 'Iodoacetates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D019807', 'descriptor_name': 'Iodoacetic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007930', 'descriptor_name': 'Leucine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007930', 'descriptor_name': 'Leucine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007976', 'descriptor_name': 'Leupeptins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009132', 'descriptor_name': 'Muscles', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D009132', 'descriptor_name': 'Muscles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009842', 'descriptor_name': 'Oligopeptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011480', 'descriptor_name': 'Protease Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/0014-5793(81)81227-6', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2881%2981227-6', 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6274695', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/0014-5793(81)81227-6', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2881%2981227-6', 'source': {'id': 'https://openalex.org/S104830714', 'display_name': 'FEBS Letters', 'issn_l': '0014-5793', 'issn': ['0014-5793', '1873-3468'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 13, 'referenced_works': ['https://openalex.org/W1570260604', 'https://openalex.org/W1966389657', 'https://openalex.org/W2013080645', 'https://openalex.org/W2069164978', 'https://openalex.org/W2075120656', 'https://openalex.org/W2097267045', 'https://openalex.org/W2100837269', 'https://openalex.org/W2102804947', 'https://openalex.org/W2103439138', 'https://openalex.org/W2137583682', 'https://openalex.org/W2165886387', 'https://openalex.org/W2167041650', 'https://openalex.org/W2176903450'], 'related_works': ['https://openalex.org/W2402548264', 'https://openalex.org/W2210490355', 'https://openalex.org/W2084547059', 'https://openalex.org/W2076570352', 'https://openalex.org/W2034590243', 'https://openalex.org/W2021576485', 'https://openalex.org/W2020638986', 'https://openalex.org/W2002641834', 'https://openalex.org/W1991443399', 'https://openalex.org/W1987894962'], 'abstract_inverted_index': {'FEBS': [0], 'LettersVolume': [1], '136,': [2], 'Issue': [3], '1': [4], 'p.': [5], '119-122': [6, 248], 'Full-length': [7], 'articleFree': [8], 'Access': [9], 'Effect': [10], 'of': [11, 16, 31, 34, 37, 53, 56, 59, 75, 101, 104, 107, 123, 126, 129, 145, 192, 202, 215, 226], 'Ca2+': [12], 'on': [13], 'the': [14, 208, 218], 'inhibition': [15], 'calcium-activated': [17], 'neutral': [18], 'protease': [19], 'by': [20, 46, 68, 93, 116, 138, 163], 'leupeptin,': [21], 'antipain': [22], 'and': [23, 83, 153, 190, 194, 206, 213, 232], 'epoxysuccinate': [24], 'derivatives': [25], 'Koichi': [26, 28, 96, 98], 'Suzuki,': [27, 97], 'Suzuki': [29, 99], 'Department': [30, 52, 100, 122], 'Biochemistry,': [32, 54, 102, 124], 'Faculty': [33, 55, 103, 125], 'Medicine,': [35, 57, 105, 127], 'University': [36, 58, 106, 128], 'Tokyo,': [38, 60, 108, 130], 'Bunkyo-ku,': [39, 61, 109, 131], 'Tokyo': [40, 62, 87, 110, 132, 157], '113,': [41, 63, 111, 133], 'JapanSearch': [42, 64, 89, 112, 134, 159], 'for': [43, 65, 80, 90, 113, 135, 150, 160], 'more': [44, 66, 91, 114, 136, 161], 'papers': [45, 67, 92, 115, 137, 162], 'this': [47, 69, 94, 117, 139, 164, 227], 'authorShuichi': [48, 118], 'Tsuji,': [49, 119], 'Shuichi': [50, 120], 'Tsuji': [51, 121], 'authorIshiura': [70, 140], 'Shoichi,': [71, 141], 'Ishiura': [72, 142], 'Shoichi': [73, 143], 'Division': [74, 144], 'Neuromuscular': [76, 146], 'Research,': [77, 147], 'National': [78, 148], 'Center': [79, 149], 'Nervous,': [81, 151], 'Mental': [82, 152], 'Muscular': [84, 154], 'Disorders,': [85, 155], 'Kodaira,': [86, 156], '187,': [88, 158], 'author': [95, 165], 'First': [166], 'published:': [167], 'December': [168], '21,': [169, 246], '1981': [170], 'https://doi.org/10.1016/0014-5793(81)81227-6Citations:': [171], '34AboutPDF': [172], 'ToolsRequest': [173], 'permissionExport': [174], 'citationAdd': [175], 'to': [176, 198, 221], 'favoritesTrack': [177], 'citation': [178], 'ShareShare': [179], 'Give': [180], 'accessShare': [181, 184], 'full': [182], 'text': [183], 'full-text': [185, 200, 224], 'accessPlease': [186], 'review': [187], 'our': [188], 'Terms': [189, 212], 'Conditions': [191, 214], 'Use': [193], 'check': [195], 'box': [196], 'below': [197, 220], 'share': [199, 222], 'version': [201, 225], 'article.I': [203], 'have': [204], 'read': [205], 'accept': [207], 'Wiley': [209], 'Online': [210], 'Library': [211], 'UseShareable': [216], 'LinkUse': [217], 'link': [219], 'a': [223, 238], 'article': [228], 'with': [229], 'your': [230], 'friends': [231], 'colleagues.': [233], 'Learn': [234], 'more.Copy': [235], 'URL': [236], 'Share': [237], 'linkShare': [239], 'onFacebookTwitterLinked': [240], 'InRedditWechat': [241], 'Citing': [242], 'Literature': [243], 'Volume136,': [244], 'Issue1December': [245], '1981Pages': [247], 'ReferencesRelatedInformation': [249]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2038514347', 'counts_by_year': [{'year': 2017, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-09T04:44:14.610578', 'created_date': '2016-06-24'}