Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1991443399', 'doi': 'https://doi.org/10.1016/0005-2744(74)90054-0', 'title': 'Role of individual cathepsins in lysosomal protein digestion as tested by specific inhibitors', 'display_name': 'Role of individual cathepsins in lysosomal protein digestion as tested by specific inhibitors', 'publication_year': 1974, 'publication_date': '1974-11-01', 'ids': {'openalex': 'https://openalex.org/W1991443399', 'doi': 'https://doi.org/10.1016/0005-2744(74)90054-0', 'mag': '1991443399', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/4429704'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0005-2744(74)90054-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210222880', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics', 'issn_l': '1570-9639', 'issn': ['1570-9639', '1878-1454'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5058402892', 'display_name': 'W. Huisman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'W. Huisman', 'raw_affiliation_strings': ['Biochemisch Laboratorium, The University of Groningen, Groningen The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Biochemisch Laboratorium, The University of Groningen, Groningen The Netherlands', 'institution_ids': ['https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083283039', 'display_name': 'Lineke Lanting', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Lineke Lanting', 'raw_affiliation_strings': ['Biochemisch Laboratorium, The University of Groningen, Groningen The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Biochemisch Laboratorium, The University of Groningen, Groningen The Netherlands', 'institution_ids': ['https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061727038', 'display_name': 'HENK DODDEMA', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'H.J. Doddema', 'raw_affiliation_strings': ['Biochemisch Laboratorium, The University of Groningen, Groningen The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Biochemisch Laboratorium, The University of Groningen, Groningen The Netherlands', 'institution_ids': ['https://openalex.org/I169381384']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053447527', 'display_name': 'J.M.W. Bouma', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'J.M.W. Bouma', 'raw_affiliation_strings': ['Biochemisch Laboratorium, The University of Groningen, Groningen The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Biochemisch Laboratorium, The University of Groningen, Groningen The Netherlands', 'institution_ids': ['https://openalex.org/I169381384']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111842337', 'display_name': 'M. Gruber', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I169381384', 'display_name': 'University of Groningen', 'ror': 'https://ror.org/012p63287', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I169381384']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'M. Gruber', 'raw_affiliation_strings': ['Biochemisch Laboratorium, The University of Groningen, Groningen The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Biochemisch Laboratorium, The University of Groningen, Groningen The Netherlands', 'institution_ids': ['https://openalex.org/I169381384']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3730, 'currency': 'USD', 'value_usd': 3730, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 6.734, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 104, 'citation_normalized_percentile': {'value': 0.855633, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '370', 'issue': '1', 'first_page': '297', 'last_page': '307'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9912, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 0.9912, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9877, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13637', 'display_name': 'Calpain Protease Function and Regulation', 'score': 0.9781, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/pepstatin', 'display_name': 'Pepstatin', 'score': 0.9876162}, {'id': 'https://openalex.org/keywords/antipain', 'display_name': 'Antipain', 'score': 0.97195053}, {'id': 'https://openalex.org/keywords/cathepsin-l', 'display_name': 'Cathepsin L', 'score': 0.52273065}, {'id': 'https://openalex.org/keywords/cathepsin-c', 'display_name': 'Cathepsin C', 'score': 0.49800944}, {'id': 'https://openalex.org/keywords/cathepsin-h', 'display_name': 'Cathepsin H', 'score': 0.46209446}, {'id': 'https://openalex.org/keywords/cathepsin-a', 'display_name': 'Cathepsin A', 'score': 0.44884595}, {'id': 'https://openalex.org/keywords/protein-degradation', 'display_name': 'Protein Degradation', 'score': 0.43789604}, {'id': 'https://openalex.org/keywords/proteolysis', 'display_name': 'Proteolysis', 'score': 0.42320263}], 'concepts': [{'id': 'https://openalex.org/C2776350231', 'wikidata': 'https://www.wikidata.org/wiki/Q7166509', 'display_name': 'Pepstatin', 'level': 4, 'score': 0.9876162}, {'id': 'https://openalex.org/C2775883766', 'wikidata': 'https://www.wikidata.org/wiki/Q11350119', 'display_name': 'Leupeptin', 'level': 4, 'score': 0.98246354}, {'id': 'https://openalex.org/C2781378782', 'wikidata': 'https://www.wikidata.org/wiki/Q96372211', 'display_name': 'Antipain', 'level': 5, 'score': 0.97195053}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.6663087}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.6189152}, {'id': 'https://openalex.org/C173633252', 'wikidata': 'https://www.wikidata.org/wiki/Q3663475', 'display_name': 'Cathepsin D', 'level': 3, 'score': 0.5863811}, {'id': 'https://openalex.org/C34695024', 'wikidata': 'https://www.wikidata.org/wiki/Q14902030', 'display_name': 'Cathepsin O', 'level': 4, 'score': 0.58596396}, {'id': 'https://openalex.org/C167844969', 'wikidata': 'https://www.wikidata.org/wiki/Q426245', 'display_name': 'Cathepsin', 'level': 3, 'score': 0.5858816}, {'id': 'https://openalex.org/C2780034444', 'wikidata': 'https://www.wikidata.org/wiki/Q5052485', 'display_name': 'Cathepsin L', 'level': 4, 'score': 0.52273065}, {'id': 'https://openalex.org/C2776125364', 'wikidata': 'https://www.wikidata.org/wiki/Q169219', 'display_name': 'Albumin', 'level': 2, 'score': 0.51780164}, {'id': 'https://openalex.org/C145734084', 'wikidata': 'https://www.wikidata.org/wiki/Q14902080', 'display_name': 'Cathepsin C', 'level': 4, 'score': 0.49800944}, {'id': 'https://openalex.org/C51618164', 'wikidata': 'https://www.wikidata.org/wiki/Q5052484', 'display_name': 'Cathepsin H', 'level': 4, 'score': 0.46209446}, {'id': 'https://openalex.org/C78553746', 'wikidata': 'https://www.wikidata.org/wiki/Q423561', 'display_name': 'Cathepsin A', 'level': 4, 'score': 0.44884595}, {'id': 'https://openalex.org/C28021979', 'wikidata': 'https://www.wikidata.org/wiki/Q14911946', 'display_name': 'Cathepsin B', 'level': 3, 'score': 0.44332364}, {'id': 'https://openalex.org/C2776714187', 'wikidata': 'https://www.wikidata.org/wiki/Q212410', 'display_name': 'Protease', 'level': 3, 'score': 0.44091097}, {'id': 'https://openalex.org/C2992195973', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Protein degradation', 'level': 2, 'score': 0.43789604}, {'id': 'https://openalex.org/C2781307694', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Proteolysis', 'level': 3, 'score': 0.42320263}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.37458292}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.373931}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23667055}], 'mesh': [{'descriptor_ui': 'D002403', 'descriptor_name': 'Cathepsins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D000135', 'descriptor_name': 'Acid Phosphatase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000135', 'descriptor_name': 'Acid Phosphatase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002403', 'descriptor_name': 'Cathepsins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002417', 'descriptor_name': 'Cattle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002712', 'descriptor_name': 'Chlorides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002712', 'descriptor_name': 'Chlorides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004229', 'descriptor_name': 'Dithiothreitol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004229', 'descriptor_name': 'Dithiothreitol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004591', 'descriptor_name': 'Electrophoresis, Polyacrylamide Gel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006863', 'descriptor_name': 'Hydrogen-Ion Concentration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007461', 'descriptor_name': 'Iodoacetates', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007461', 'descriptor_name': 'Iodoacetates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011092', 'descriptor_name': 'Polyethylene Glycols', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011092', 'descriptor_name': 'Polyethylene Glycols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012710', 'descriptor_name': 'Serum Albumin, Bovine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013696', 'descriptor_name': 'Temperature', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/0005-2744(74)90054-0', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210222880', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics', 'issn_l': '1570-9639', 'issn': ['1570-9639', '1878-1454'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/4429704', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'score': 0.44, 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 34, 'referenced_works': ['https://openalex.org/W127084926', 'https://openalex.org/W1481576954', 'https://openalex.org/W1484740986', 'https://openalex.org/W1501885095', 'https://openalex.org/W1548213021', 'https://openalex.org/W1775749144', 'https://openalex.org/W1968863999', 'https://openalex.org/W1970743785', 'https://openalex.org/W1977004629', 'https://openalex.org/W1977976545', 'https://openalex.org/W1977994076', 'https://openalex.org/W1986479868', 'https://openalex.org/W1991725534', 'https://openalex.org/W1996021681', 'https://openalex.org/W1998919086', 'https://openalex.org/W1999789402', 'https://openalex.org/W2046682016', 'https://openalex.org/W2048094093', 'https://openalex.org/W2066506931', 'https://openalex.org/W2076848220', 'https://openalex.org/W2081608503', 'https://openalex.org/W2088499165', 'https://openalex.org/W2091358974', 'https://openalex.org/W20915926', 'https://openalex.org/W2092010291', 'https://openalex.org/W2094506465', 'https://openalex.org/W2172091239', 'https://openalex.org/W2323612361', 'https://openalex.org/W2403695867', 'https://openalex.org/W2415205045', 'https://openalex.org/W2417154503', 'https://openalex.org/W2437375403', 'https://openalex.org/W2596611148', 'https://openalex.org/W4248353065'], 'related_works': ['https://openalex.org/W2562931037', 'https://openalex.org/W2435355987', 'https://openalex.org/W2330782653', 'https://openalex.org/W2090842707', 'https://openalex.org/W2074984096', 'https://openalex.org/W2029200442', 'https://openalex.org/W2027353944', 'https://openalex.org/W1997872977', 'https://openalex.org/W1984592674', 'https://openalex.org/W119608788'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1991443399', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-11T05:08:55.554906', 'created_date': '2016-06-24'}