Title: Characterisation of new analogues of palytoxin isolated from an<i>Ostreopsis mascarenensis</i>bloom in the south-western Indian Ocean
Abstract:Abstract A preliminary screening of toxins of the crude extract of Ostreopsis mascarenensis Quod, a benthic dinoflagellate from the south-western Indian Ocean, revealed a neurotoxicity in mice similar...Abstract A preliminary screening of toxins of the crude extract of Ostreopsis mascarenensis Quod, a benthic dinoflagellate from the south-western Indian Ocean, revealed a neurotoxicity in mice similar to that induced by palytoxin, one of the most potent marine toxins involved in seafood poisoning. The highest toxicity was retained in the butanol-soluble fraction, revealing a strong haemolytic activity, as found for palytoxin. Analyses using high-performance liquid chromatography with ultraviolet detection allowed the detection of two new toxins named mascarenotoxins (McTXs). Their mass spectrum profile and fragmentation pattern, obtained by advanced nano-ESI-Q-TOF mass spectrometry of purified McTXs, were similar to those of a reference palytoxin. They were identified as palytoxin analogues, with the characterisation of a specific fragment ion m/z 327. O. mascarenensis is a species not previously known to produce palytoxin analogues. Keywords: ANALOGUESLC-UV AND LCMS/MS METHODOSTREOPSIS SPECIESPALYTOXINRead More
Publication Year: 2006
Publication Date: 2006-09-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 16
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