Publication Information

{'id': 'https://openalex.org/W2034560886', 'doi': 'https://doi.org/10.1034/j.1600-0854.2003.00070.x', 'title': 'A Class of Mutant CHO Cells Resistant to Cholera Toxin Rapidly Degrades the Catalytic Polypeptide of Cholera Toxin and Exhibits Increased Endoplasmic Reticulum‐Associated Degradation', 'display_name': 'A Class of Mutant CHO Cells Resistant to Cholera Toxin Rapidly Degrades the Catalytic Polypeptide of Cholera Toxin and Exhibits Increased Endoplasmic Reticulum‐Associated Degradation', 'publication_year': 2003, 'publication_date': '2003-04-01', 'ids': {'openalex': 'https://openalex.org/W2034560886', 'doi': 'https://doi.org/10.1034/j.1600-0854.2003.00070.x', 'mag': '2034560886', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12694562'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1034/j.1600-0854.2003.00070.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1034/j.1600-0854.2003.00070.x', 'source': {'id': 'https://openalex.org/S174148068', 'display_name': 'Traffic', 'issn_l': '1398-9219', 'issn': ['1398-9219', '1600-0854'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1034/j.1600-0854.2003.00070.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054026012', 'display_name': 'Ken Teter', 'orcid': 'https://orcid.org/0000-0003-4176-9361'}, 'institutions': [{'id': 'https://openalex.org/I51713134', 'display_name': 'University of Colorado Anschutz Medical Campus', 'ror': 'https://ror.org/03wmf1y16', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I51713134']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ken Teter', 'raw_affiliation_strings': ['Department of Microbiology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver 80262, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver 80262, USA.', 'institution_ids': ['https://openalex.org/I51713134']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086410531', 'display_name': 'Michael G. Jobling', 'orcid': 'https://orcid.org/0000-0001-7689-3093'}, 'institutions': [{'id': 'https://openalex.org/I51713134', 'display_name': 'University of Colorado Anschutz Medical Campus', 'ror': 'https://ror.org/03wmf1y16', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I51713134']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael G. Jobling', 'raw_affiliation_strings': ['Department of Microbiology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA.', 'institution_ids': ['https://openalex.org/I51713134']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5051273903', 'display_name': 'Randall K. Holmes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802236040', 'display_name': 'University of Colorado System', 'ror': 'https://ror.org/00jc20583', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I2802236040']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Randall K. Holmes', 'raw_affiliation_strings': ['Univ. of Colorado'], 'affiliations': [{'raw_affiliation_string': 'Univ. of Colorado', 'institution_ids': ['https://openalex.org/I2802236040']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4220, 'currency': 'USD', 'value_usd': 4220, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.789, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 47, 'citation_normalized_percentile': {'value': 0.759124, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '4', 'issue': '4', 'first_page': '232', 'last_page': '242'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12856', 'display_name': 'Transgenic Plants and Applications', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/endoplasmic-reticulum-associated-protein-degradation', 'display_name': 'Endoplasmic-reticulum-associated protein degradation', 'score': 0.8275432}, {'id': 'https://openalex.org/keywords/cholera-toxin', 'display_name': 'Cholera toxin', 'score': 0.70975447}, {'id': 'https://openalex.org/keywords/kdel', 'display_name': 'KDEL', 'score': 0.63379085}, {'id': 'https://openalex.org/keywords/pseudomonas-exotoxin', 'display_name': 'Pseudomonas exotoxin', 'score': 0.566894}, {'id': 'https://openalex.org/keywords/exotoxin', 'display_name': 'Exotoxin', 'score': 0.47349295}, {'id': 'https://openalex.org/keywords/ricin', 'display_name': 'Ricin', 'score': 0.4413607}], 'concepts': [{'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.963854}, {'id': 'https://openalex.org/C158619295', 'wikidata': 'https://www.wikidata.org/wiki/Q21101062', 'display_name': 'Endoplasmic-reticulum-associated protein degradation', 'level': 4, 'score': 0.8275432}, {'id': 'https://openalex.org/C2777006276', 'wikidata': 'https://www.wikidata.org/wiki/Q83586', 'display_name': 'Cholera toxin', 'level': 2, 'score': 0.70975447}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7043154}, {'id': 'https://openalex.org/C2779377555', 'wikidata': 'https://www.wikidata.org/wiki/Q6327751', 'display_name': 'KDEL', 'level': 4, 'score': 0.63379085}, {'id': 'https://openalex.org/C182179738', 'wikidata': 'https://www.wikidata.org/wiki/Q907386', 'display_name': 'Pseudomonas exotoxin', 'level': 4, 'score': 0.566894}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4762854}, {'id': 'https://openalex.org/C2778723905', 'wikidata': 'https://www.wikidata.org/wiki/Q408649', 'display_name': 'Exotoxin', 'level': 3, 'score': 0.47349295}, {'id': 'https://openalex.org/C2777200438', 'wikidata': 'https://www.wikidata.org/wiki/Q408668', 'display_name': 'Ricin', 'level': 3, 'score': 0.4413607}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.32184994}, {'id': 'https://openalex.org/C2777367657', 'wikidata': 'https://www.wikidata.org/wiki/Q184651', 'display_name': 'Toxin', 'level': 2, 'score': 0.26488823}, {'id': 'https://openalex.org/C119062480', 'wikidata': 'https://www.wikidata.org/wiki/Q83181', 'display_name': 'Golgi apparatus', 'level': 3, 'score': 0.25917894}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.19539657}, {'id': 'https://openalex.org/C139447449', 'wikidata': 'https://www.wikidata.org/wiki/Q14633900', 'display_name': 'Unfolded protein response', 'level': 3, 'score': 0.18479094}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.066067696}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002772', 'descriptor_name': 'Cholera Toxin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016466', 'descriptor_name': 'CHO Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002384', 'descriptor_name': 'Catalysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002772', 'descriptor_name': 'Cholera Toxin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002772', 'descriptor_name': 'Cholera Toxin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003546', 'descriptor_name': 'Cysteine Endopeptidases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003546', 'descriptor_name': 'Cysteine Endopeptidases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003593', 'descriptor_name': 'Cytoplasm', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003593', 'descriptor_name': 'Cytoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004721', 'descriptor_name': 'Endoplasmic Reticulum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006868', 'descriptor_name': 'Hydrolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009097', 'descriptor_name': 'Multienzyme Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009097', 'descriptor_name': 'Multienzyme Complexes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D046988', 'descriptor_name': 'Proteasome Endopeptidase Complex', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1034/j.1600-0854.2003.00070.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1034/j.1600-0854.2003.00070.x', 'source': {'id': 'https://openalex.org/S174148068', 'display_name': 'Traffic', 'issn_l': '1398-9219', 'issn': ['1398-9219', '1600-0854'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12694562', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1034/j.1600-0854.2003.00070.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1034/j.1600-0854.2003.00070.x', 'source': {'id': 'https://openalex.org/S174148068', 'display_name': 'Traffic', 'issn_l': '1398-9219', 'issn': ['1398-9219', '1600-0854'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Life on land', 'id': 'https://metadata.un.org/sdg/15', 'score': 0.41}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1485332704', 'https://openalex.org/W1489591743', 'https://openalex.org/W1494865255', 'https://openalex.org/W1553768169', 'https://openalex.org/W1592615086', 'https://openalex.org/W1596448669', 'https://openalex.org/W1843935642', 'https://openalex.org/W1940632338', 'https://openalex.org/W1959389258', 'https://openalex.org/W1973963032', 'https://openalex.org/W1980775568', 'https://openalex.org/W1986186343', 'https://openalex.org/W1992946884', 'https://openalex.org/W1994880461', 'https://openalex.org/W1999289759', 'https://openalex.org/W2009664225', 'https://openalex.org/W2012939559', 'https://openalex.org/W2030670856', 'https://openalex.org/W2033179504', 'https://openalex.org/W2045893780', 'https://openalex.org/W2052549964', 'https://openalex.org/W2056775389', 'https://openalex.org/W2058757351', 'https://openalex.org/W2067963440', 'https://openalex.org/W2085648931', 'https://openalex.org/W2094614534', 'https://openalex.org/W2106778710', 'https://openalex.org/W2113571259', 'https://openalex.org/W2118597394', 'https://openalex.org/W2120365956', 'https://openalex.org/W2124476511', 'https://openalex.org/W2126753022', 'https://openalex.org/W2127310249', 'https://openalex.org/W2133311104', 'https://openalex.org/W2140305640', 'https://openalex.org/W2140631633', 'https://openalex.org/W2178557511', 'https://openalex.org/W2402316897', 'https://openalex.org/W4242507630'], 'related_works': ['https://openalex.org/W3168270255', 'https://openalex.org/W2745560200', 'https://openalex.org/W2421331648', 'https://openalex.org/W2413325023', 'https://openalex.org/W2153934618', 'https://openalex.org/W2053404437', 'https://openalex.org/W1991811755', 'https://openalex.org/W1917568389', 'https://openalex.org/W1589088345', 'https://openalex.org/W1550052423'], 'abstract_inverted_index': {'After': [0], 'binding': [1], 'to': [2, 12, 61, 111, 148], 'the': [3, 13, 26, 32, 40, 69, 142, 170, 184, 192, 197, 218, 223, 235, 248], 'eukaryotic': [4], 'cell': [5], 'surface,': [6], 'cholera': [7, 21, 149, 240], 'toxin': [8, 22, 252, 255], 'undergoes': [9], 'retrograde': [10], 'transport': [11], 'endoplasmic': [14, 27, 46, 63, 97, 136, 156, 166, 224, 231], 'reticulum.': [15, 225], 'The': [16], 'catalytic': [17], 'A1': [18], 'polypeptide': [19], 'of': [20, 118, 154, 163, 173, 180], '(CTA1)': [23], 'then': [24], 'crosses': [25], 'reticulum': [28], 'membrane': [29], 'and': [30, 56, 81, 93, 104, 176, 183, 254], 'enters': [31], 'cytosol': [33, 219], 'in': [34, 217, 222, 234], 'a': [35, 86, 119, 210, 239], 'process': [36], 'that': [37, 84, 133, 214, 229], 'may': [38], 'involve': [39], 'quality': [41], 'control': [42], 'mechanism': [43], 'known': [44], 'as': [45, 52], 'reticulum‐associated': [47, 64, 137, 167, 232], 'degradation.': [48, 138], 'Other': [49], 'toxins': [50, 99], 'such': [51], 'Pseudomonas': [53, 90, 129, 242], 'exotoxin': [54, 91, 130, 243], 'A': [55, 92], 'ricin': [57], 'are': [58], 'also': [59], 'thought': [60], 'exploit': [62], 'degradation': [65, 153, 162, 168, 233, 256], 'for': [66], 'entry': [67], 'into': [68], 'cytosol.': [70], 'To': [71], 'test': [72], 'this': [73], 'model,': [74], 'we': [75, 126], 'mutagenized': [76], 'Chinese': [77], 'hamster': [78], 'ovary': [79], 'cells': [80], 'selected': [82], 'clones': [83, 132, 140, 199, 237], 'survived': [85], 'prolonged': [87], 'coincubation': [88], 'with': [89], 'ricin.': [94], 'These': [95, 226], 'lethal': [96], 'reticulum‐translocating': [98], 'bind': [100], 'different': [101, 106], 'surface': [102], 'receptors': [103], 'target': [105], 'cytosolic': [107, 207], 'substrates,': [108], 'so': [109], 'resistance': [110, 147], 'both': [112, 181], 'would': [113], 'likely': [114], 'result': [115], 'from': [116], 'disruption': [117], 'shared': [120], 'trafficking': [121], 'or': [122], 'translocation': [123, 253], 'event.': [124], 'Here': [125], 'characterize': [127], 'two': [128], 'A/ricin‐resistant': [131, 244], 'exhibited': [134], 'increased': [135, 152, 161, 203], 'Both': [139], 'acquired': [141], 'following': [143], 'unselected': [144], 'traits:': [145], '(i)': [146], 'toxin;': [150], '(ii)': [151], 'an': [155, 164], 'reticulum‐localized': [157], 'CTA1': [158, 212], 'construct;': [159], '(iii)': [160], 'established': [165], 'substrate,': [169], 'Z': [171], 'variant': [172], 'α1‐antitrypsin': [174], '(α1AT‐Z);': [175], '(iv)': [177], 'reduced': [178], 'secretion': [179, 194], 'α1AT‐Z': [182], 'transport‐competent': [185], 'protein': [186], 'α1AT‐M.': [187], 'Proteosome': [188], 'inhibition': [189], 'partially': [190], 'rescued': [191], 'α1AT‐M': [193], 'deficiencies.': [195], 'However,': [196], 'mutant': [198, 236], 'did': [200], 'not': [201], 'exhibit': [202], 'proteosomal': [204], 'activity': [205], 'against': [206], 'proteins,': [208], 'including': [209], 'second': [211], 'construct': [213], 'was': [215], 'expressed': [216], 'rather': [220], 'than': [221], 'results': [227], 'suggested': [228], 'accelerated': [230], 'produced': [238], 'toxin/': [241], 'phenotype': [245], 'by': [246], 'increasing': [247], 'coupling': [249], 'efficiency': [250], 'between': [251], '.': [257]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2034560886', 'counts_by_year': [{'year': 2022, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-13T11:30:38.694014', 'created_date': '2016-06-24'}