Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W3168270255', 'doi': 'https://doi.org/10.1096/fasebj.2021.35.s1.04779', 'title': 'The Influence of Furin and the KDEL Receptor on the Efficacy of Recombinant Immunotoxins based on <i>Pseudomonas</i> Exotoxin A', 'display_name': 'The Influence of Furin and the KDEL Receptor on the Efficacy of Recombinant Immunotoxins based on <i>Pseudomonas</i> Exotoxin A', 'publication_year': 2021, 'publication_date': '2021-05-01', 'ids': {'openalex': 'https://openalex.org/W3168270255', 'doi': 'https://doi.org/10.1096/fasebj.2021.35.s1.04779', 'mag': '3168270255'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fasebj.2021.35.s1.04779', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005504705', 'display_name': 'Yuyi Zhu', 'orcid': 'https://orcid.org/0009-0000-9770-9611'}, 'institutions': [{'id': 'https://openalex.org/I4322298', 'display_name': 'Towson University', 'ror': 'https://ror.org/044w7a341', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4322298']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yuyi Zhu', 'raw_affiliation_strings': ['Biological Sciences, Towson University, Towson, MD'], 'affiliations': [{'raw_affiliation_string': 'Biological Sciences, Towson University, Towson, MD', 'institution_ids': ['https://openalex.org/I4322298']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5005963576', 'display_name': 'John E. Weldon', 'orcid': 'https://orcid.org/0000-0002-6516-9064'}, 'institutions': [{'id': 'https://openalex.org/I4322298', 'display_name': 'Towson University', 'ror': 'https://ror.org/044w7a341', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I4322298']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John Weldon', 'raw_affiliation_strings': ['Biological Sciences, Towson University, Towson, MD'], 'affiliations': [{'raw_affiliation_string': 'Biological Sciences, Towson University, Towson, MD', 'institution_ids': ['https://openalex.org/I4322298']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 57}, 'biblio': {'volume': '35', 'issue': 'S1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12477', 'display_name': 'Toxin Mechanisms and Immunotoxins', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11048', 'display_name': 'Bacteriophages and microbial interactions', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2303', 'display_name': 'Ecology'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11455', 'display_name': 'Microbial Inactivation Methods', 'score': 0.9793, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/kdel', 'display_name': 'KDEL', 'score': 0.98581064}, {'id': 'https://openalex.org/keywords/furin', 'display_name': 'Furin', 'score': 0.96650183}, {'id': 'https://openalex.org/keywords/pseudomonas-exotoxin', 'display_name': 'Pseudomonas exotoxin', 'score': 0.8713526}, {'id': 'https://openalex.org/keywords/hek-293-cells', 'display_name': 'HEK 293 cells', 'score': 0.53596807}], 'concepts': [{'id': 'https://openalex.org/C2779377555', 'wikidata': 'https://www.wikidata.org/wiki/Q6327751', 'display_name': 'KDEL', 'level': 4, 'score': 0.98581064}, {'id': 'https://openalex.org/C2777265534', 'wikidata': 'https://www.wikidata.org/wiki/Q14916427', 'display_name': 'Furin', 'level': 3, 'score': 0.96650183}, {'id': 'https://openalex.org/C182179738', 'wikidata': 'https://www.wikidata.org/wiki/Q907386', 'display_name': 'Pseudomonas exotoxin', 'level': 4, 'score': 0.8713526}, {'id': 'https://openalex.org/C115085202', 'wikidata': 'https://www.wikidata.org/wiki/Q425665', 'display_name': 'Immunotoxin', 'level': 4, 'score': 0.74740314}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.62498266}, {'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.61560565}, {'id': 'https://openalex.org/C174510640', 'wikidata': 'https://www.wikidata.org/wiki/Q489618', 'display_name': 'HEK 293 cells', 'level': 3, 'score': 0.53596807}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5215637}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.47684944}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.47351483}, {'id': 'https://openalex.org/C54009773', 'wikidata': 'https://www.wikidata.org/wiki/Q1429031', 'display_name': 'Transfection', 'level': 3, 'score': 0.45937857}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.44375038}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4334252}, {'id': 'https://openalex.org/C175656101', 'wikidata': 'https://www.wikidata.org/wiki/Q56646', 'display_name': 'Chinese hamster ovary cell', 'level': 3, 'score': 0.4191171}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.3785953}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.33077747}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16920465}, {'id': 'https://openalex.org/C119062480', 'wikidata': 'https://www.wikidata.org/wiki/Q83181', 'display_name': 'Golgi apparatus', 'level': 3, 'score': 0.16158181}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.12054178}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1109049}, {'id': 'https://openalex.org/C542903549', 'wikidata': 'https://www.wikidata.org/wiki/Q422248', 'display_name': 'Monoclonal antibody', 'level': 3, 'score': 0.084515035}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0782367}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.06826392}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1096/fasebj.2021.35.s1.04779', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.73, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4383374385', 'https://openalex.org/W3176409755', 'https://openalex.org/W3168270255', 'https://openalex.org/W2909145676', 'https://openalex.org/W2770380181', 'https://openalex.org/W2491001938', 'https://openalex.org/W2460813870', 'https://openalex.org/W2354898668', 'https://openalex.org/W2349885609', 'https://openalex.org/W1954790131'], 'abstract_inverted_index': {'Recombinant': [0], 'immunotoxins': [1], '(RITs)': [2], 'are': [3, 13, 44], 'targeted': [4], 'immunotherapeutics': [5], 'for': [6], 'the': [7, 57, 60, 68, 76, 91, 99, 102, 133, 140, 154, 177, 182, 220, 225, 232, 236, 246], 'treatment': [8], 'of': [9, 15, 88, 132, 137, 179, 184, 222, 235, 248], 'cancers.': [10], 'Most': [11], 'RITs': [12, 31, 43, 159], 'composed': [14], 'an': [16], 'antibody': [17], 'fragment': [18], 'joined': [19], 'to': [20, 39, 75, 174, 218, 230, 240, 244, 251, 261], 'a': [21, 33, 212], 'bacterial': [22], 'toxin': [23], 'such': [24], 'as': [25], 'Pseudomonas': [26], 'exotoxin': [27], 'A': [28], '(PE).': [29], 'PE-based': [30], 'undergo': [32], 'complex': [34], 'intoxication': [35], 'pathway': [36], 'in': [37, 123, 176], 'order': [38], 'kill': [40], 'cells.': [41], 'First,': [42], 'internalized': [45], 'by': [46, 86], 'receptor-mediated': [47], 'endocytosis': [48], 'upon': [49], 'engagement': [50], 'with': [51, 90, 139, 197], 'their': [52], 'cognate': [53], 'receptor.': [54, 93, 227], 'Then,': [55], 'within': [56], 'endolysosomal': [58], 'system,': [59], 'protease': [61], 'furin': [62, 180, 200, 223], 'cleaves': [63], 'RITs,': [64], 'separating': [65], 'PE': [66, 71, 89, 95, 105, 138], 'from': [67, 73, 98, 216], 'antibody.': [69], 'Next,': [70], 'traffics': [72], 'endosomes': [74], 'endoplasmic': [77], 'reticulum': [78], '(ER)': [79], 'via': [80], 'retrograde': [81], 'transport.': [82], 'This': [83, 112, 256], 'is': [84, 96], 'mediated': [85], 'interaction': [87], 'KDEL': [92, 142, 226], 'Finally,': [94], 'exported': [97], 'ER': [100], 'into': [101], 'cytosol,': [103], 'where': [104], 'covalently': [106], 'modifies': [107], 'translation': [108], 'elongation': [109], 'factor-2': [110], '(EF2).': [111], 'halts': [113], 'protein': [114], 'synthesis': [115], 'and': [116, 126, 163, 198, 224, 254], 'induces': [117], 'apoptotic': [118], 'cell': [119, 164, 195, 238], 'death.': [120], 'Previous': [121], 'research': [122], 'our': [124], 'lab': [125], 'others': [127], 'has': [128], 'demonstrated': [129], 'that': [130, 168, 201], 'replacement': [131], 'C-terminal': [134], 'REDLK': [135], 'sequence': [136, 143], 'canonical': [141], 'can': [144], 'enhance': [145], 'RIT': [146, 242, 252], 'efficacy.': [147], 'When': [148], 'we': [149], 'evaluated': [150], 'this': [151], 'improvement,': [152], 'however,': [153], 'enhancement': [155], 'varied': [156], 'widely': [157], 'among': [158], 'targeting': [160], 'different': [161, 185, 241], 'receptors': [162], 'lines.': [165], 'I': [166, 191, 228], 'hypothesized': [167], 'these': [169, 189, 249], 'differences': [170], 'could': [171], 'be': [172, 259], 'due': [173], 'variations': [175], 'expression': [178], 'or': [181, 206], 'trafficking': [183, 253], 'receptors.': [186], 'To': [187], 'investigate': [188], 'possibilities,': [190], 'have': [192], 'created': [193], 'HEK293': [194, 209], 'lines': [196, 239], 'without': [199], 'express': [202], 'uncommon': [203], 'receptors,': [204], 'CD22': [205], 'mesothelin.': [207], 'These': [208], 'cells': [210], 'provide': [211], 'uniform': [213], 'genetic': [214], 'background': [215], 'which': [217], 'study': [219], 'roles': [221], 'plan': [229], 'compare': [231], 'relative': [233], 'sensitivity': [234], 'transgenic': [237], 'constructs': [243], 'determine': [245], 'contribution': [247], 'factors': [250], 'cytotoxicity.': [255], 'information': [257], 'will': [258], 'used': [260], 'develop': [262], 'improved': [263], 'RIT-based': [264], 'cancer': [265], 'therapies.': [266]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W3168270255', 'counts_by_year': [], 'updated_date': '2025-01-17T12:40:54.772868', 'created_date': '2021-06-22'}