Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2033186130', 'doi': 'https://doi.org/10.1016/j.mce.2014.05.001', 'title': 'Phosphodiesterase 2 negatively regulates adenosine-induced transcription of the tyrosine hydroxylase gene in PC12 rat pheochromocytoma cells', 'display_name': 'Phosphodiesterase 2 negatively regulates adenosine-induced transcription of the tyrosine hydroxylase gene in PC12 rat pheochromocytoma cells', 'publication_year': 2014, 'publication_date': '2014-07-01', 'ids': {'openalex': 'https://openalex.org/W2033186130', 'doi': 'https://doi.org/10.1016/j.mce.2014.05.001', 'mag': '2033186130', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24837549'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.mce.2014.05.001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S191044671', 'display_name': 'Molecular and Cellular Endocrinology', 'issn_l': '0303-7207', 'issn': ['0303-7207', '1872-8057'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008815816', 'display_name': 'Edyta Makuch', 'orcid': 'https://orcid.org/0000-0001-7971-0109'}, 'institutions': [{'id': 'https://openalex.org/I4210163977', 'display_name': 'Ludwik Hirszfeld Institute of Immunology and Experimental Therapy', 'ror': 'https://ror.org/05b7p8k90', 'country_code': 'PL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210163977', 'https://openalex.org/I99542240']}, {'id': 'https://openalex.org/I99542240', 'display_name': 'Polish Academy of Sciences', 'ror': 'https://ror.org/01dr6c206', 'country_code': 'PL', 'type': 'government', 'lineage': ['https://openalex.org/I99542240']}], 'countries': ['PL'], 'is_corresponding': True, 'raw_author_name': 'Edyta Makuch', 'raw_affiliation_strings': ['Laboratory of Signaling Proteins, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Signaling Proteins, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland', 'institution_ids': ['https://openalex.org/I4210163977', 'https://openalex.org/I99542240']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017597908', 'display_name': 'M Kuropatwa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210163977', 'display_name': 'Ludwik Hirszfeld Institute of Immunology and Experimental Therapy', 'ror': 'https://ror.org/05b7p8k90', 'country_code': 'PL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210163977', 'https://openalex.org/I99542240']}, {'id': 'https://openalex.org/I99542240', 'display_name': 'Polish Academy of Sciences', 'ror': 'https://ror.org/01dr6c206', 'country_code': 'PL', 'type': 'government', 'lineage': ['https://openalex.org/I99542240']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Marianna Kuropatwa', 'raw_affiliation_strings': ['Laboratory of Signaling Proteins, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Signaling Proteins, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland', 'institution_ids': ['https://openalex.org/I4210163977', 'https://openalex.org/I99542240']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080348243', 'display_name': 'Ewa Kurowska', 'orcid': 'https://orcid.org/0000-0001-5259-4443'}, 'institutions': [{'id': 'https://openalex.org/I4210163977', 'display_name': 'Ludwik Hirszfeld Institute of Immunology and Experimental Therapy', 'ror': 'https://ror.org/05b7p8k90', 'country_code': 'PL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210163977', 'https://openalex.org/I99542240']}, {'id': 'https://openalex.org/I99542240', 'display_name': 'Polish Academy of Sciences', 'ror': 'https://ror.org/01dr6c206', 'country_code': 'PL', 'type': 'government', 'lineage': ['https://openalex.org/I99542240']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Ewa Kurowska', 'raw_affiliation_strings': ['Laboratory of Signaling Proteins, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Signaling Proteins, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland', 'institution_ids': ['https://openalex.org/I4210163977', 'https://openalex.org/I99542240']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017236798', 'display_name': 'Jarosław Ciekot', 'orcid': 'https://orcid.org/0000-0001-6883-2338'}, 'institutions': [{'id': 'https://openalex.org/I4210163977', 'display_name': 'Ludwik Hirszfeld Institute of Immunology and Experimental Therapy', 'ror': 'https://ror.org/05b7p8k90', 'country_code': 'PL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210163977', 'https://openalex.org/I99542240']}, {'id': 'https://openalex.org/I99542240', 'display_name': 'Polish Academy of Sciences', 'ror': 'https://ror.org/01dr6c206', 'country_code': 'PL', 'type': 'government', 'lineage': ['https://openalex.org/I99542240']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Jaroslaw Ciekot', 'raw_affiliation_strings': ['Laboratory of Biomedical Chemistry "Neolek", Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Biomedical Chemistry "Neolek", Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland', 'institution_ids': ['https://openalex.org/I4210163977', 'https://openalex.org/I99542240']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035881316', 'display_name': 'Dagmara Kłopotowska', 'orcid': 'https://orcid.org/0000-0002-1574-1106'}, 'institutions': [{'id': 'https://openalex.org/I4210163977', 'display_name': 'Ludwik Hirszfeld Institute of Immunology and Experimental Therapy', 'ror': 'https://ror.org/05b7p8k90', 'country_code': 'PL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210163977', 'https://openalex.org/I99542240']}, {'id': 'https://openalex.org/I99542240', 'display_name': 'Polish Academy of Sciences', 'ror': 'https://ror.org/01dr6c206', 'country_code': 'PL', 'type': 'government', 'lineage': ['https://openalex.org/I99542240']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Dagmara Klopotowska', 'raw_affiliation_strings': ['Laboratory of Experimental Anticancer Therapy "Neolek", Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Experimental Anticancer Therapy "Neolek", Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland', 'institution_ids': ['https://openalex.org/I4210163977', 'https://openalex.org/I99542240']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5050041795', 'display_name': 'Janusz Matuszyk', 'orcid': 'https://orcid.org/0000-0002-0382-1272'}, 'institutions': [{'id': 'https://openalex.org/I4210163977', 'display_name': 'Ludwik Hirszfeld Institute of Immunology and Experimental Therapy', 'ror': 'https://ror.org/05b7p8k90', 'country_code': 'PL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210163977', 'https://openalex.org/I99542240']}, {'id': 'https://openalex.org/I99542240', 'display_name': 'Polish Academy of Sciences', 'ror': 'https://ror.org/01dr6c206', 'country_code': 'PL', 'type': 'government', 'lineage': ['https://openalex.org/I99542240']}], 'countries': ['PL'], 'is_corresponding': False, 'raw_author_name': 'Janusz Matuszyk', 'raw_affiliation_strings': ['Laboratory of Signaling Proteins, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Signaling Proteins, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland', 'institution_ids': ['https://openalex.org/I4210163977', 'https://openalex.org/I99542240']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5008815816'], 'corresponding_institution_ids': ['https://openalex.org/I4210163977', 'https://openalex.org/I99542240'], 'apc_list': {'value': 3000, 'currency': 'USD', 'value_usd': 3000, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 66}, 'biblio': {'volume': '392', 'issue': '1-2', 'first_page': '51', 'last_page': '59'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12434', 'display_name': 'Molecular Regulation and Clinical Applications of PDEs', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12434', 'display_name': 'Molecular Regulation and Clinical Applications of PDEs', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10198', 'display_name': 'Diagnosis and Treatment of Heart Failure', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11001', 'display_name': 'Renin-Angiotensin System in Cardiovascular Physiology and Pathology', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/angiotensin-ii-receptor', 'display_name': 'Angiotensin II Receptor', 'score': 0.478714}, {'id': 'https://openalex.org/keywords/pde10a', 'display_name': 'PDE10A', 'score': 0.46375376}, {'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription (linguistics)', 'score': 0.45934045}, {'id': 'https://openalex.org/keywords/phosphodiesterase-3', 'display_name': 'Phosphodiesterase 3', 'score': 0.4356762}], 'concepts': [{'id': 'https://openalex.org/C2776991684', 'wikidata': 'https://www.wikidata.org/wiki/Q190012', 'display_name': 'Adenosine', 'level': 2, 'score': 0.6767073}, {'id': 'https://openalex.org/C62826618', 'wikidata': 'https://www.wikidata.org/wiki/Q424304', 'display_name': 'Phosphodiesterase', 'level': 3, 'score': 0.56807745}, {'id': 'https://openalex.org/C159167319', 'wikidata': 'https://www.wikidata.org/wiki/Q420766', 'display_name': 'Tyrosine hydroxylase', 'level': 3, 'score': 0.56529593}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.54806817}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.48121884}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.47431326}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.46638846}, {'id': 'https://openalex.org/C79418042', 'wikidata': 'https://www.wikidata.org/wiki/Q5864325', 'display_name': 'PDE10A', 'level': 4, 'score': 0.46375376}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.45934045}, {'id': 'https://openalex.org/C58141971', 'wikidata': 'https://www.wikidata.org/wiki/Q906688', 'display_name': 'Phosphodiesterase 3', 'level': 4, 'score': 0.4356762}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.42154112}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.390857}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.36560774}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.33075}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.23785883}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15709743}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.06903231}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.057094812}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000241', 'descriptor_name': 'Adenosine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000310', 'descriptor_name': 'Adrenal Gland Neoplasms', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D000310', 'descriptor_name': 'Adrenal Gland Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D054678', 'descriptor_name': 'Cyclic Nucleotide Phosphodiesterases, Type 2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010673', 'descriptor_name': 'Pheochromocytoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D014446', 'descriptor_name': 'Tyrosine 3-Monooxygenase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000241', 'descriptor_name': 'Adenosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000310', 'descriptor_name': 'Adrenal Gland Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009320', 'descriptor_name': 'Atrial Natriuretic Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009320', 'descriptor_name': 'Atrial Natriuretic Factor', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000242', 'descriptor_name': 'Cyclic AMP', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000242', 'descriptor_name': 'Cyclic AMP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017362', 'descriptor_name': 'Cyclic AMP Response Element-Binding Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017362', 'descriptor_name': 'Cyclic AMP Response Element-Binding Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006152', 'descriptor_name': 'Cyclic GMP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006152', 'descriptor_name': 'Cyclic GMP', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D054678', 'descriptor_name': 'Cyclic Nucleotide Phosphodiesterases, Type 2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016716', 'descriptor_name': 'PC12 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010673', 'descriptor_name': 'Pheochromocytoma', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D010673', 'descriptor_name': 'Pheochromocytoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011401', 'descriptor_name': 'Promoter Regions, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014446', 'descriptor_name': 'Tyrosine 3-Monooxygenase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014446', 'descriptor_name': 'Tyrosine 3-Monooxygenase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.mce.2014.05.001', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S191044671', 'display_name': 'Molecular and Cellular Endocrinology', 'issn_l': '0303-7207', 'issn': ['0303-7207', '1872-8057'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24837549', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.41, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1538325952', 'https://openalex.org/W1558386025', 'https://openalex.org/W1713577217', 'https://openalex.org/W1964720242', 'https://openalex.org/W1967543124', 'https://openalex.org/W1970486454', 'https://openalex.org/W1970625220', 'https://openalex.org/W1982414891', 'https://openalex.org/W1983934270', 'https://openalex.org/W1986071704', 'https://openalex.org/W1993428746', 'https://openalex.org/W2001821930', 'https://openalex.org/W2030732769', 'https://openalex.org/W2035130508', 'https://openalex.org/W2035303003', 'https://openalex.org/W2038761191', 'https://openalex.org/W2039661360', 'https://openalex.org/W2041292257', 'https://openalex.org/W2041502163', 'https://openalex.org/W2051337690', 'https://openalex.org/W2055745355', 'https://openalex.org/W2056275306', 'https://openalex.org/W2062554994', 'https://openalex.org/W2065564312', 'https://openalex.org/W2068592086', 'https://openalex.org/W2069847580', 'https://openalex.org/W2077881960', 'https://openalex.org/W2081120934', 'https://openalex.org/W2086238151', 'https://openalex.org/W2090368102', 'https://openalex.org/W2099303231', 'https://openalex.org/W2104214454', 'https://openalex.org/W2105977137', 'https://openalex.org/W2107277218', 'https://openalex.org/W2108651626', 'https://openalex.org/W2118462346', 'https://openalex.org/W2128725121', 'https://openalex.org/W2138216041', 'https://openalex.org/W2150279512', 'https://openalex.org/W2154457951', 'https://openalex.org/W2168675611', 'https://openalex.org/W2172094801'], 'related_works': ['https://openalex.org/W4230851220', 'https://openalex.org/W2116859828', 'https://openalex.org/W2096988953', 'https://openalex.org/W2096716690', 'https://openalex.org/W2030697191', 'https://openalex.org/W2007897250', 'https://openalex.org/W1988408001', 'https://openalex.org/W1968217178', 'https://openalex.org/W1959582949', 'https://openalex.org/W1676724278'], 'abstract_inverted_index': {'Adenosine': [0], 'induces': [1], 'expression': [2, 22, 133], 'of': [3, 23, 42, 47, 49, 57, 101, 111, 116, 119, 130, 136], 'the': [4, 39, 43, 60, 87, 91, 120], 'tyrosine': [5], 'hydroxylase': [6], '(TH)': [7], 'gene': [8, 132], 'in': [9, 63, 85, 140], 'PC12': [10, 141], 'cells.': [11, 142], 'However,': [12], 'it': [13], 'is': [14, 83], 'suggested': [15], 'that': [16, 35, 54, 81, 97, 125], 'atrial': [17], 'natriuretic': [18], 'peptide': [19], '(ANP)': [20], 'inhibits': [21, 59], 'this': [24], 'gene.': [25, 45, 122], 'Using': [26, 66], 'real-time': [27], 'PCR': [28], 'and': [29, 72], 'luciferase': [30], 'reporter': [31], 'assays': [32], 'we': [33, 79], 'found': [34, 80], 'ANP': [36, 126], 'significantly': [37], 'decreases': [38], 'adenosine-induced': [40, 61, 117], 'transcription': [41, 118], 'TH': [44, 121, 131], 'Results': [46], 'measurements': [48], 'cyclic': [50], 'nucleotide': [51], 'concentrations': [52], 'indicated': [53], 'ANP-induced': [55, 98], 'accumulation': [56], 'cGMP': [58, 75, 102, 106], 'increase': [62], 'cAMP': [64, 92, 138], 'level.': [65], 'selective': [67], 'phosphodiesterase': [68], '2': [69], '(PDE2)': [70], 'inhibitors': [71], 'a': [73], 'synthetic': [74], 'analog': [76, 107], 'activating': [77], 'PDE2,': [78, 112], 'PDE2': [82], 'involved': [84], 'coupling': [86], 'ANP-triggered': [88], 'signal': [89], 'to': [90, 114], 'metabolism.': [93], 'We': [94, 123], 'have': [95], 'established': [96], 'elevated': [99], 'levels': [100], 'as': [103, 105], 'well': [104], 'stimulate': [108], 'hydrolytic': [109], 'activity': [110], 'leading': [113], 'inhibition': [115], 'conclude': [124], 'mediates': [127], 'negative': [128], 'regulation': [129], 'via': [134], 'stimulation': [135], 'PDE2-dependent': [137], 'breakdown': [139]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2033186130', 'counts_by_year': [], 'updated_date': '2024-08-28T05:07:15.982585', 'created_date': '2016-06-24'}