Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2032788851', 'doi': 'https://doi.org/10.4161/cc.9.17.13048', 'title': 'Targeting autophagy to fight hematopoietic malignancies', 'display_name': 'Targeting autophagy to fight hematopoietic malignancies', 'publication_year': 2010, 'publication_date': '2010-09-01', 'ids': {'openalex': 'https://openalex.org/W2032788851', 'doi': 'https://doi.org/10.4161/cc.9.17.13048', 'mag': '2032788851', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20703092'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/cc.9.17.13048', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.4161/cc.9.17.13048?needAccess=true', 'source': {'id': 'https://openalex.org/S86011449', 'display_name': 'Cell Cycle', 'issn_l': '1551-4005', 'issn': ['1551-4005', '1538-4101'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.tandfonline.com/doi/pdf/10.4161/cc.9.17.13048?needAccess=true', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5038903944', 'display_name': 'Alexandre Puissant', 'orcid': 'https://orcid.org/0000-0002-3997-9282'}, 'institutions': [{'id': 'https://openalex.org/I4210118460', 'display_name': "Hôpital l'Archet", 'ror': 'https://ror.org/02fsxgh46', 'country_code': 'FR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I201841394', 'https://openalex.org/I3018988418', 'https://openalex.org/I4210118460']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Alexandre Puissant', 'raw_affiliation_strings': ["INSERM U895, Batiment Universitaire ARCHIMED, CHU Hopital de l'Archet, Nice Cedex, France."], 'affiliations': [{'raw_affiliation_string': "INSERM U895, Batiment Universitaire ARCHIMED, CHU Hopital de l'Archet, Nice Cedex, France.", 'institution_ids': ['https://openalex.org/I4210118460', 'https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051365781', 'display_name': 'Guillaume Robert', 'orcid': 'https://orcid.org/0000-0002-6350-2222'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Guillaume Robert', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5039959145', 'display_name': 'Patrick Auberger', 'orcid': 'https://orcid.org/0000-0002-2481-8275'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Patrick Auberger', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.232, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 72, 'citation_normalized_percentile': {'value': 0.740007, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '9', 'issue': '17', 'first_page': '3470', 'last_page': '3478'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13415', 'display_name': 'Calcium signaling and nucleotide metabolism', 'score': 0.9818, 'subfield': {'id': 'https://openalex.org/subfields/1314', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10952', 'display_name': 'PI3K/AKT/mTOR signaling in cancer', 'score': 0.9485, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.9485159}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.8017076}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.7485769}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.65723747}, {'id': 'https://openalex.org/C109159458', 'wikidata': 'https://www.wikidata.org/wiki/Q919283', 'display_name': 'Haematopoiesis', 'level': 3, 'score': 0.50314397}, {'id': 'https://openalex.org/C86554907', 'wikidata': 'https://www.wikidata.org/wiki/Q285613', 'display_name': 'PI3K/AKT/mTOR pathway', 'level': 3, 'score': 0.48141977}, {'id': 'https://openalex.org/C98490376', 'wikidata': 'https://www.wikidata.org/wiki/Q14876060', 'display_name': 'mTORC1', 'level': 4, 'score': 0.4635524}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.4548973}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.2104711}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.2050516}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.20323643}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.12171176}], 'mesh': [{'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019337', 'descriptor_name': 'Hematologic Neoplasms', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019337', 'descriptor_name': 'Hematologic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D019337', 'descriptor_name': 'Hematologic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015451', 'descriptor_name': 'Leukemia, Lymphocytic, Chronic, B-Cell', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D015451', 'descriptor_name': 'Leukemia, Lymphocytic, Chronic, B-Cell', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D015451', 'descriptor_name': 'Leukemia, Lymphocytic, Chronic, B-Cell', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015470', 'descriptor_name': 'Leukemia, Myeloid, Acute', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D015470', 'descriptor_name': 'Leukemia, Myeloid, Acute', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D015470', 'descriptor_name': 'Leukemia, Myeloid, Acute', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009101', 'descriptor_name': 'Multiple Myeloma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009190', 'descriptor_name': 'Myelodysplastic Syndromes', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009190', 'descriptor_name': 'Myelodysplastic Syndromes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009190', 'descriptor_name': 'Myelodysplastic Syndromes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054198', 'descriptor_name': 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D054198', 'descriptor_name': 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D054198', 'descriptor_name': 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D058570', 'descriptor_name': 'TOR Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/cc.9.17.13048', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.4161/cc.9.17.13048?needAccess=true', 'source': {'id': 'https://openalex.org/S86011449', 'display_name': 'Cell Cycle', 'issn_l': '1551-4005', 'issn': ['1551-4005', '1538-4101'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20703092', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4161/cc.9.17.13048', 'pdf_url': 'https://www.tandfonline.com/doi/pdf/10.4161/cc.9.17.13048?needAccess=true', 'source': {'id': 'https://openalex.org/S86011449', 'display_name': 'Cell Cycle', 'issn_l': '1551-4005', 'issn': ['1551-4005', '1538-4101'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.73, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 38, 'referenced_works': ['https://openalex.org/W177963654', 'https://openalex.org/W1963617699', 'https://openalex.org/W1972618720', 'https://openalex.org/W1973472942', 'https://openalex.org/W1975317091', 'https://openalex.org/W1981247200', 'https://openalex.org/W1988327539', 'https://openalex.org/W1989764974', 'https://openalex.org/W1991300803', 'https://openalex.org/W1996812090', 'https://openalex.org/W2002636911', 'https://openalex.org/W2019178802', 'https://openalex.org/W2024650854', 'https://openalex.org/W2027442494', 'https://openalex.org/W2037711165', 'https://openalex.org/W2038405639', 'https://openalex.org/W2042377836', 'https://openalex.org/W2044874695', 'https://openalex.org/W2054293224', 'https://openalex.org/W2064203037', 'https://openalex.org/W2064605990', 'https://openalex.org/W2070224555', 'https://openalex.org/W2086853865', 'https://openalex.org/W2092315599', 'https://openalex.org/W2093083083', 'https://openalex.org/W2101428185', 'https://openalex.org/W2109034822', 'https://openalex.org/W2113492659', 'https://openalex.org/W2119041481', 'https://openalex.org/W2122355707', 'https://openalex.org/W2125798501', 'https://openalex.org/W2127054377', 'https://openalex.org/W2128058282', 'https://openalex.org/W2134138119', 'https://openalex.org/W2136088181', 'https://openalex.org/W2154663531', 'https://openalex.org/W2161735692', 'https://openalex.org/W2168576472'], 'related_works': ['https://openalex.org/W4283275596', 'https://openalex.org/W2988428292', 'https://openalex.org/W2905399276', 'https://openalex.org/W2890156259', 'https://openalex.org/W2388475655', 'https://openalex.org/W2163381356', 'https://openalex.org/W2012224340', 'https://openalex.org/W2010008722', 'https://openalex.org/W1989202029', 'https://openalex.org/W1482038694'], 'abstract_inverted_index': {'Macroautophagy,': [0], 'referred': [1], 'hereafter': [2], 'to': [3, 64, 142, 193, 203], 'as': [4, 198], 'autophagy': [5, 84, 138, 152, 183], 'is': [6, 25, 132, 154], 'an': [7], 'evolutionary': [8], 'conserved': [9], 'catabolic': [10], 'process': [11, 122], 'for': [12], 'the': [13, 44, 67, 71, 79, 117, 124, 157, 168, 174, 180, 191, 195], 'degradation': [14], 'and': [15, 21, 35, 129, 165, 186, 189], 'recycling': [16, 77], 'of': [17, 46, 103, 120, 126, 145, 160, 182], 'macromolecules,': [18], 'bulk': [19], 'cytoplasm': [20], 'dammaged': [22], 'organelles.': [23, 58], 'Autophagy': [24], 'activated': [26], 'under': [27, 88, 93], 'stress': [28], 'conditions': [29], 'induced': [30], 'by': [31, 43, 156, 167], 'nutrient': [32], 'deprivation,': [33], 'hypoxia': [34], 'drug': [36], 'treatments.': [37], 'Morphologically,': [38], 'autophagic': [39, 96, 112], 'cells': [40, 97], 'are': [41, 74], 'characterized': [42], 'accumulation': [45], 'double': [47], 'membrane': [48], 'cytoplasmic': [49, 55], 'vesicules': [50], 'called': [51, 106], 'autophagosomes': [52], 'that': [53, 135], 'surrounds': [54], 'proteins': [56], 'and/or': [57], 'Autophagosomes': [59], 'next': [60], 'fuse': [61], 'with': [62, 207], 'lysosomes': [63], 'generate': [65], 'autolysosomes,': [66], 'structures': [68], 'in': [69, 137, 184], 'which': [70], 'retained': [72], 'constituents': [73], 'digested': [75], 'before': [76], 'into': [78], 'cytoplasm.': [80], 'In': [81, 91, 173], 'this': [82, 121], 'context,': [83], 'promotes': [85], 'cell': [86, 104, 109, 113, 127], 'survival': [87], 'adverse': [89], 'conditions.': [90], 'contrast,': [92], 'certain': [94], 'circumstances': [95], 'may': [98], 'engage': [99], 'a': [100, 143, 199, 208], 'specific': [101], 'mode': [102], 'death': [105, 110, 114, 128], 'type': [107], 'II': [108], 'or': [111], '(ACD).': [115], 'Considering': [116], 'strategic': [118], 'positionnement': [119], 'at': [123], 'crossroads': [125], 'survival,': [130], 'it': [131], 'not': [133], 'surprising': [134], 'defects': [136], 'have': [139], 'been': [140], 'linked': [141], 'plethora': [144], 'human': [146], 'diseases,': [147], 'including': [148], 'hematopoietic': [149, 205], 'malignancies.': [150], 'Finally,': [151], 'induction': [153], 'repressed': [155], 'mammalian': [158], 'target': [159, 194], 'rapamycin': [161], 'complex': [162], '1': [163], '(mTORC1)': [164], 'favored': [166], 'adenosine-monophosphate': [169], 'activated-protein': [170], 'kinase': [171], '(AMPK).': [172], 'present': [175], 'review,': [176], 'we': [177], 'focus': [178], 'on': [179, 211], 'functions': [181], 'normal': [185], 'malignant': [187], 'hematopoiesis': [188], 'discuss': [190], 'opportunity': [192], 'AMPK/mTOR': [196], 'pathways': [197], 'new': [200], 'therapeutic': [201], 'strategy': [202], 'fight': [204], 'malignancies': [206], 'special': [209], 'emphasis': [210], 'Chronic': [212], 'Myelogenous': [213], 'Leukemia': [214], '(CML).': [215]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2032788851', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 8}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-08T17:27:47.497624', 'created_date': '2016-06-24'}