Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W4283275596', 'doi': 'https://doi.org/10.3390/biom12070866', 'title': 'Life and Death Decisions—The Many Faces of Autophagy in Cell Survival and Cell Death', 'display_name': 'Life and Death Decisions—The Many Faces of Autophagy in Cell Survival and Cell Death', 'publication_year': 2022, 'publication_date': '2022-06-21', 'ids': {'openalex': 'https://openalex.org/W4283275596', 'doi': 'https://doi.org/10.3390/biom12070866', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/35883421'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/biom12070866', 'pdf_url': 'https://www.mdpi.com/2218-273X/12/7/866/pdf?version=1655814320', 'source': {'id': 'https://openalex.org/S4210236520', 'display_name': 'Biomolecules', 'issn_l': '2218-273X', 'issn': ['2218-273X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.mdpi.com/2218-273X/12/7/866/pdf?version=1655814320', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5073590077', 'display_name': 'Ge Yu', 'orcid': 'https://orcid.org/0000-0002-3908-899X'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ge Yu', 'raw_affiliation_strings': ['Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2216, USA', 'Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA'], 'affiliations': [{'raw_affiliation_string': 'Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2216, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5066515392', 'display_name': 'Daniel J. Klionsky', 'orcid': 'https://orcid.org/0000-0002-7828-8118'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Daniel J. Klionsky', 'raw_affiliation_strings': ['Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2216, USA', 'Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA'], 'affiliations': [{'raw_affiliation_string': 'Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA', 'institution_ids': ['https://openalex.org/I27837315']}, {'raw_affiliation_string': 'Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109-2216, USA', 'institution_ids': ['https://openalex.org/I27837315']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5066515392'], 'corresponding_institution_ids': ['https://openalex.org/I27837315'], 'apc_list': {'value': 2100, 'currency': 'CHF', 'value_usd': 2273, 'provenance': 'doaj'}, 'apc_paid': {'value': 2100, 'currency': 'CHF', 'value_usd': 2273, 'provenance': 'doaj'}, 'fwci': 1.75, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 24, 'citation_normalized_percentile': {'value': 0.999598, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '12', 'issue': '7', 'first_page': '866', 'last_page': '866'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10587', 'display_name': 'Autophagy in Disease and Therapy', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/crosstalk', 'display_name': 'Crosstalk', 'score': 0.63186365}], 'concepts': [{'id': 'https://openalex.org/C203522944', 'wikidata': 'https://www.wikidata.org/wiki/Q288322', 'display_name': 'Autophagy', 'level': 3, 'score': 0.98699605}, {'id': 'https://openalex.org/C31573885', 'wikidata': 'https://www.wikidata.org/wiki/Q304484', 'display_name': 'Programmed cell death', 'level': 3, 'score': 0.8617759}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.786826}, {'id': 'https://openalex.org/C169822122', 'wikidata': 'https://www.wikidata.org/wiki/Q230187', 'display_name': 'Crosstalk', 'level': 2, 'score': 0.63186365}, {'id': 'https://openalex.org/C102568950', 'wikidata': 'https://www.wikidata.org/wiki/Q127702', 'display_name': 'Vacuole', 'level': 3, 'score': 0.6119972}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6095466}, {'id': 'https://openalex.org/C190062978', 'wikidata': 'https://www.wikidata.org/wiki/Q79899', 'display_name': 'Cytoplasm', 'level': 2, 'score': 0.5579265}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.5562793}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.44548148}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.42222798}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.120318234}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C120665830', 'wikidata': 'https://www.wikidata.org/wiki/Q14620', 'display_name': 'Optics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001343', 'descriptor_name': 'Autophagy', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D016923', 'descriptor_name': 'Cell Death', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012441', 'descriptor_name': 'Saccharomyces cerevisiae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/biom12070866', 'pdf_url': 'https://www.mdpi.com/2218-273X/12/7/866/pdf?version=1655814320', 'source': {'id': 'https://openalex.org/S4210236520', 'display_name': 'Biomolecules', 'issn_l': '2218-273X', 'issn': ['2218-273X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313301', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/35883421', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3390/biom12070866', 'pdf_url': 'https://www.mdpi.com/2218-273X/12/7/866/pdf?version=1655814320', 'source': {'id': 'https://openalex.org/S4210236520', 'display_name': 'Biomolecules', 'issn_l': '2218-273X', 'issn': ['2218-273X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310310987', 'host_organization_name': 'Multidisciplinary Digital Publishing Institute', 'host_organization_lineage': ['https://openalex.org/P4310310987'], 'host_organization_lineage_names': ['Multidisciplinary Digital Publishing Institute'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.68}], 'grants': [{'funder': 'https://openalex.org/F4320337354', 'funder_display_name': 'National Institute of General Medical Sciences', 'award_id': 'GM131919'}], 'datasets': [], 'versions': [], 'referenced_works_count': 87, 'referenced_works': ['https://openalex.org/W1560977824', 'https://openalex.org/W1942767863', 'https://openalex.org/W1972336737', 'https://openalex.org/W1972432707', 'https://openalex.org/W1980305749', 'https://openalex.org/W1983467638', 'https://openalex.org/W1987695408', 'https://openalex.org/W1992637754', 'https://openalex.org/W1992659717', 'https://openalex.org/W1996152690', 'https://openalex.org/W2001675597', 'https://openalex.org/W2009741382', 'https://openalex.org/W2011580247', 'https://openalex.org/W2015503148', 'https://openalex.org/W2021011570', 'https://openalex.org/W2026860604', 'https://openalex.org/W2028304108', 'https://openalex.org/W2032700869', 'https://openalex.org/W2041943889', 'https://openalex.org/W2045457634', 'https://openalex.org/W2046205790', 'https://openalex.org/W2047242847', 'https://openalex.org/W2054815464', 'https://openalex.org/W2055731427', 'https://openalex.org/W2056274991', 'https://openalex.org/W2065060908', 'https://openalex.org/W2067684692', 'https://openalex.org/W2068275754', 'https://openalex.org/W2074272918', 'https://openalex.org/W2079355772', 'https://openalex.org/W2085470568', 'https://openalex.org/W2086107258', 'https://openalex.org/W2088962120', 'https://openalex.org/W2091469763', 'https://openalex.org/W2095238101', 'https://openalex.org/W2097830998', 'https://openalex.org/W2102601355', 'https://openalex.org/W2103628478', 'https://openalex.org/W2103851013', 'https://openalex.org/W2106195012', 'https://openalex.org/W2111362374', 'https://openalex.org/W2113464867', 'https://openalex.org/W2119851117', 'https://openalex.org/W2120595804', 'https://openalex.org/W2132146273', 'https://openalex.org/W2136994247', 'https://openalex.org/W2137690550', 'https://openalex.org/W2143161560', 'https://openalex.org/W2144404276', 'https://openalex.org/W2156171182', 'https://openalex.org/W2158535498', 'https://openalex.org/W2171243762', 'https://openalex.org/W2172108417', 'https://openalex.org/W2415787897', 'https://openalex.org/W2560020248', 'https://openalex.org/W2566427422', 'https://openalex.org/W2576890255', 'https://openalex.org/W2592593829', 'https://openalex.org/W2621289937', 'https://openalex.org/W2748829107', 'https://openalex.org/W2758797028', 'https://openalex.org/W2763871199', 'https://openalex.org/W2768129277', 'https://openalex.org/W2788640168', 'https://openalex.org/W2792549532', 'https://openalex.org/W2793199383', 'https://openalex.org/W2795906582', 'https://openalex.org/W2811443127', 'https://openalex.org/W2887998229', 'https://openalex.org/W2902863353', 'https://openalex.org/W2905399276', 'https://openalex.org/W2920882938', 'https://openalex.org/W2923204865', 'https://openalex.org/W2943908983', 'https://openalex.org/W2951686954', 'https://openalex.org/W3011802680', 'https://openalex.org/W3022464411', 'https://openalex.org/W3092024834', 'https://openalex.org/W3108936441', 'https://openalex.org/W3157582528', 'https://openalex.org/W3159899764', 'https://openalex.org/W3207282310', 'https://openalex.org/W4210284474', 'https://openalex.org/W4220778713', 'https://openalex.org/W4220910428', 'https://openalex.org/W4229024039', 'https://openalex.org/W66711298'], 'related_works': ['https://openalex.org/W2919042118', 'https://openalex.org/W2886343980', 'https://openalex.org/W2367559322', 'https://openalex.org/W2336003703', 'https://openalex.org/W2159372512', 'https://openalex.org/W2094712522', 'https://openalex.org/W2087642137', 'https://openalex.org/W2053099864', 'https://openalex.org/W1995893937', 'https://openalex.org/W1482038694'], 'abstract_inverted_index': {'Autophagy': [0, 114], 'is': [1, 59, 126], 'a': [2, 137, 146, 167], 'process': [3], 'conserved': [4], 'from': [5], 'yeast': [6], 'to': [7, 34, 43, 60, 64, 86, 165], 'humans.': [8], 'Since': [9], 'the': [10, 31, 65, 74, 77, 95, 98, 109, 155, 161, 180, 184, 196], 'discovery': [11], 'of': [12, 30, 57, 81, 97, 105, 112, 119, 139, 187, 199], 'autophagy,': [13, 73], 'its': [14, 192], 'physiological': [15, 185], 'role': [16, 56, 111, 186], 'in': [17, 45, 51, 84, 101, 201], 'cell': [18, 21, 46, 49, 75, 121, 133, 152, 162, 170, 173, 202, 205], 'survival': [19, 47, 171, 203], 'and': [20, 37, 48, 79, 131, 151, 172, 194, 204], 'death': [22, 50, 134], 'has': [23, 93], 'been': [24], 'intensively': [25], 'investigated.': [26], 'The': [27, 54], 'inherent': [28], 'ability': [29], 'autophagy': [32, 42, 58, 99, 130, 150, 164, 188, 200], 'machinery': [33, 100], 'sequester,': [35], 'deliver,': [36], 'degrade': [38], 'cytoplasmic': [39, 62, 82], 'components': [40, 63, 83], 'enables': [41], 'participate': [44], 'multiple': [52, 197], 'ways.': [53], 'primary': [55], 'send': [61], 'vacuole': [66], 'or': [67, 89], 'lysosomes': [68], 'for': [69], 'degradation.': [70], 'By': [71], 'fine-tuning': [72], 'regulates': [76], 'removal': [78], 'recycling': [80], 'response': [85], 'various': [87], 'stress': [88], 'signals.': [90], 'Recent': [91], 'research': [92], 'shown': [94], 'implications': [96], 'other': [102], 'pathways': [103], 'independent': [104], 'lysosomal': [106], 'degradation,': [107], 'expanding': [108], 'pro-survival': [110], 'autophagy.': [113], 'also': [115], 'facilitates': [116], 'certain': [117], 'forms': [118], 'regulated': [120, 132], 'death.': [122, 153, 174, 206], 'In': [123, 175], 'addition,': [124], 'there': [125], 'complex': [127], 'crosstalk': [128], 'between': [129, 142, 149, 169], 'pathways,': [135], 'with': [136], 'number': [138], 'genes': [140], 'shared': [141], 'them,': [143], 'further': [144], 'suggesting': [145], 'deeper': [147], 'connection': [148], 'Finally,': [154], 'mitochondrion': [156], 'presents': [157], 'an': [158], 'example': [159], 'where': [160], 'utilizes': [163], 'strike': [166], 'balance': [168], 'this': [176], 'review,': [177], 'we': [178], 'consider': [179], 'current': [181], 'knowledge': [182], 'on': [183], 'as': [189, 191], 'well': [190], 'regulation': [193], 'discuss': [195], 'functions': [198]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W4283275596', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 1}], 'updated_date': '2024-12-21T04:20:55.267353', 'created_date': '2022-06-23'}