Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2031449170', 'doi': 'https://doi.org/10.1016/j.bbamem.2006.08.007', 'title': 'Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases', 'display_name': 'Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases', 'publication_year': 2006, 'publication_date': '2006-12-01', 'ids': {'openalex': 'https://openalex.org/W2031449170', 'doi': 'https://doi.org/10.1016/j.bbamem.2006.08.007', 'mag': '2031449170', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16996023'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbamem.2006.08.007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210187475', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Biomembranes', 'issn_l': '0005-2736', 'issn': ['0005-2736', '1879-2642'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5026510433', 'display_name': 'Nitai C. Hait', 'orcid': 'https://orcid.org/0000-0001-7707-425X'}, 'institutions': [{'id': 'https://openalex.org/I184840846', 'display_name': 'Virginia Commonwealth University', 'ror': 'https://ror.org/02nkdxk79', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I184840846']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Nitai C. Hait', 'raw_affiliation_strings': ['Department of Biochemistry, Virginia Commonwealth University School of Medicine, 1101 E. Marshall St., Richmond, VA 23298-0614, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Virginia Commonwealth University School of Medicine, 1101 E. Marshall St., Richmond, VA 23298-0614, USA', 'institution_ids': ['https://openalex.org/I184840846']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061926035', 'display_name': 'Carole A. Oskeritzian', 'orcid': 'https://orcid.org/0000-0003-1380-9186'}, 'institutions': [{'id': 'https://openalex.org/I184840846', 'display_name': 'Virginia Commonwealth University', 'ror': 'https://ror.org/02nkdxk79', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I184840846']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carole A. Oskeritzian', 'raw_affiliation_strings': ['Department of Biochemistry, Virginia Commonwealth University School of Medicine, 1101 E. Marshall St., Richmond, VA 23298-0614, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Virginia Commonwealth University School of Medicine, 1101 E. Marshall St., Richmond, VA 23298-0614, USA', 'institution_ids': ['https://openalex.org/I184840846']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080486902', 'display_name': 'Steven W. Paugh', 'orcid': 'https://orcid.org/0000-0001-5697-9228'}, 'institutions': [{'id': 'https://openalex.org/I184840846', 'display_name': 'Virginia Commonwealth University', 'ror': 'https://ror.org/02nkdxk79', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I184840846']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven W. Paugh', 'raw_affiliation_strings': ['Department of Biochemistry, Virginia Commonwealth University School of Medicine, 1101 E. Marshall St., Richmond, VA 23298-0614, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Virginia Commonwealth University School of Medicine, 1101 E. Marshall St., Richmond, VA 23298-0614, USA', 'institution_ids': ['https://openalex.org/I184840846']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011102538', 'display_name': 'Sheldon Milstien', 'orcid': 'https://orcid.org/0000-0003-0728-837X'}, 'institutions': [{'id': 'https://openalex.org/I4210158500', 'display_name': 'National Institute of Mental Health', 'ror': 'https://ror.org/04xeg9z08', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210158500']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sheldon Milstien', 'raw_affiliation_strings': ['Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, MD 20892, USA'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, MD 20892, USA', 'institution_ids': ['https://openalex.org/I4210158500']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5014072958', 'display_name': 'Sarah Spiegel', 'orcid': 'https://orcid.org/0000-0003-0751-2634'}, 'institutions': [{'id': 'https://openalex.org/I184840846', 'display_name': 'Virginia Commonwealth University', 'ror': 'https://ror.org/02nkdxk79', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I184840846']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Sarah Spiegel', 'raw_affiliation_strings': ['Department of Biochemistry, Virginia Commonwealth University School of Medicine, 1101 E. Marshall St., Richmond, VA 23298-0614, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Virginia Commonwealth University School of Medicine, 1101 E. Marshall St., Richmond, VA 23298-0614, USA', 'institution_ids': ['https://openalex.org/I184840846']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5014072958'], 'corresponding_institution_ids': ['https://openalex.org/I184840846'], 'apc_list': {'value': 3980, 'currency': 'USD', 'value_usd': 3980, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.712, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 451, 'citation_normalized_percentile': {'value': 0.999676, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '1758', 'issue': '12', 'first_page': '2016', 'last_page': '2026'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Signalling and Metabolism in Health and Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Signalling and Metabolism in Health and Disease', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10617', 'display_name': 'Mechanisms of Intracellular Membrane Trafficking', 'score': 0.9979, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Unfolded Protein Response', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sphingolipid', 'display_name': 'Sphingolipid', 'score': 0.79925895}, {'id': 'https://openalex.org/keywords/sphingosine-1-phosphate', 'display_name': 'Sphingosine-1-Phosphate', 'score': 0.588115}, {'id': 'https://openalex.org/keywords/sphingosine-kinase', 'display_name': 'Sphingosine Kinase', 'score': 0.579722}], 'concepts': [{'id': 'https://openalex.org/C2777700496', 'wikidata': 'https://www.wikidata.org/wiki/Q7576797', 'display_name': 'Sphingosine kinase', 'level': 5, 'score': 0.9371865}, {'id': 'https://openalex.org/C2778703144', 'wikidata': 'https://www.wikidata.org/wiki/Q46298', 'display_name': 'Sphingosine', 'level': 3, 'score': 0.9089336}, {'id': 'https://openalex.org/C2776596873', 'wikidata': 'https://www.wikidata.org/wiki/Q418267', 'display_name': 'Sphingosine-1-phosphate', 'level': 4, 'score': 0.8087434}, {'id': 'https://openalex.org/C61705674', 'wikidata': 'https://www.wikidata.org/wiki/Q410395', 'display_name': 'Sphingolipid', 'level': 2, 'score': 0.79925895}, {'id': 'https://openalex.org/C2777851122', 'wikidata': 'https://www.wikidata.org/wiki/Q424213', 'display_name': 'Ceramide', 'level': 3, 'score': 0.755731}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.7093967}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.6506556}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5638565}, {'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.5519037}, {'id': 'https://openalex.org/C180899940', 'wikidata': 'https://www.wikidata.org/wiki/Q117982', 'display_name': 'Lipid signaling', 'level': 3, 'score': 0.54186934}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.5057273}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.46549022}, {'id': 'https://openalex.org/C28406088', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Extracellular', 'level': 2, 'score': 0.4375733}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.33442172}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.32667553}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004194', 'descriptor_name': 'Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008246', 'descriptor_name': 'Lysophospholipids', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017853', 'descriptor_name': 'Phosphotransferases (Alcohol Group Acceptor)', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008246', 'descriptor_name': 'Lysophospholipids', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D008246', 'descriptor_name': 'Lysophospholipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017853', 'descriptor_name': 'Phosphotransferases (Alcohol Group Acceptor)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D013110', 'descriptor_name': 'Sphingosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.bbamem.2006.08.007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210187475', 'display_name': 'Biochimica et Biophysica Acta (BBA) - Biomembranes', 'issn_l': '0005-2736', 'issn': ['0005-2736', '1879-2642'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16996023', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 135, 'referenced_works': ['https://openalex.org/W1544152865', 'https://openalex.org/W1595397037', 'https://openalex.org/W1598200894', 'https://openalex.org/W1599277155', 'https://openalex.org/W1607699671', 'https://openalex.org/W1634220494', 'https://openalex.org/W1761319647', 'https://openalex.org/W1827287971', 'https://openalex.org/W1856672768', 'https://openalex.org/W1881674564', 'https://openalex.org/W1937674947', 'https://openalex.org/W1963551043', 'https://openalex.org/W1970174185', 'https://openalex.org/W1971392424', 'https://openalex.org/W1973458872', 'https://openalex.org/W1973573934', 'https://openalex.org/W1974829480', 'https://openalex.org/W1977644244', 'https://openalex.org/W1978527995', 'https://openalex.org/W1981071904', 'https://openalex.org/W1981932258', 'https://openalex.org/W1984179269', 'https://openalex.org/W1985202015', 'https://openalex.org/W1986426214', 'https://openalex.org/W1989138941', 'https://openalex.org/W1989975786', 'https://openalex.org/W1993449698', 'https://openalex.org/W1994248356', 'https://openalex.org/W1995391501', 'https://openalex.org/W1997469380', 'https://openalex.org/W1999975964', 'https://openalex.org/W2001956269', 'https://openalex.org/W2002201938', 'https://openalex.org/W2002487087', 'https://openalex.org/W2006711474', 'https://openalex.org/W2006717761', 'https://openalex.org/W2006985918', 'https://openalex.org/W2007878869', 'https://openalex.org/W2008265157', 'https://openalex.org/W2016087648', 'https://openalex.org/W2017564052', 'https://openalex.org/W2018528407', 'https://openalex.org/W2019889454', 'https://openalex.org/W2019904737', 'https://openalex.org/W2021153400', 'https://openalex.org/W2021331088', 'https://openalex.org/W2021722796', 'https://openalex.org/W2021877299', 'https://openalex.org/W2022770236', 'https://openalex.org/W2023166258', 'https://openalex.org/W2024106968', 'https://openalex.org/W2024964264', 'https://openalex.org/W2028378028', 'https://openalex.org/W2029641949', 'https://openalex.org/W2030594678', 'https://openalex.org/W2032620622', 'https://openalex.org/W2035897334', 'https://openalex.org/W2036300443', 'https://openalex.org/W2039198468', 'https://openalex.org/W2040698057', 'https://openalex.org/W2041000246', 'https://openalex.org/W2043112660', 'https://openalex.org/W2046278419', 'https://openalex.org/W2046592989', 'https://openalex.org/W2047231993', 'https://openalex.org/W2047645266', 'https://openalex.org/W2049863334', 'https://openalex.org/W2053310582', 'https://openalex.org/W2053900021', 'https://openalex.org/W2054820743', 'https://openalex.org/W2055636600', 'https://openalex.org/W2056418403', 'https://openalex.org/W2056899647', 'https://openalex.org/W2062851728', 'https://openalex.org/W2063858579', 'https://openalex.org/W2064379250', 'https://openalex.org/W2064686935', 'https://openalex.org/W2066717022', 'https://openalex.org/W2068013069', 'https://openalex.org/W2070265046', 'https://openalex.org/W2070341850', 'https://openalex.org/W2070482516', 'https://openalex.org/W2075468442', 'https://openalex.org/W2075926091', 'https://openalex.org/W2076091755', 'https://openalex.org/W2076136942', 'https://openalex.org/W2077827642', 'https://openalex.org/W2078219311', 'https://openalex.org/W2078845055', 'https://openalex.org/W2084993188', 'https://openalex.org/W2086905823', 'https://openalex.org/W2090542818', 'https://openalex.org/W2091423973', 'https://openalex.org/W2092113592', 'https://openalex.org/W2093852073', 'https://openalex.org/W2094554783', 'https://openalex.org/W2096273281', 'https://openalex.org/W2100041813', 'https://openalex.org/W2101722374', 'https://openalex.org/W2103598907', 'https://openalex.org/W2108091182', 'https://openalex.org/W2108352126', 'https://openalex.org/W2110388058', 'https://openalex.org/W2111134333', 'https://openalex.org/W2118649335', 'https://openalex.org/W2121890980', 'https://openalex.org/W2123556335', 'https://openalex.org/W2125890824', 'https://openalex.org/W2127330795', 'https://openalex.org/W2131731146', 'https://openalex.org/W2132579946', 'https://openalex.org/W2132805096', 'https://openalex.org/W2136920332', 'https://openalex.org/W2140053474', 'https://openalex.org/W2140636998', 'https://openalex.org/W2143068056', 'https://openalex.org/W2147336880', 'https://openalex.org/W2149441416', 'https://openalex.org/W2151948261', 'https://openalex.org/W2153904682', 'https://openalex.org/W2154089780', 'https://openalex.org/W2155952015', 'https://openalex.org/W2156494795', 'https://openalex.org/W2160917745', 'https://openalex.org/W2162468322', 'https://openalex.org/W2164422031', 'https://openalex.org/W2164522180', 'https://openalex.org/W2165204073', 'https://openalex.org/W2165308436', 'https://openalex.org/W2168026099', 'https://openalex.org/W2170519462', 'https://openalex.org/W2279323582', 'https://openalex.org/W4230277786', 'https://openalex.org/W4243707169', 'https://openalex.org/W4294658238'], 'related_works': ['https://openalex.org/W4255675750', 'https://openalex.org/W4243027891', 'https://openalex.org/W2086674389', 'https://openalex.org/W2084654786', 'https://openalex.org/W2071704583', 'https://openalex.org/W2061137389', 'https://openalex.org/W2059246206', 'https://openalex.org/W2042678520', 'https://openalex.org/W2003007879', 'https://openalex.org/W114681587'], 'abstract_inverted_index': {'Sphingolipids': [0], 'are': [1, 31, 96], 'ubiquitous': [2], 'components': [3], 'of': [4, 23, 43, 49, 57, 80, 86, 99, 109, 140], 'cell': [5, 24], 'membranes': [6], 'and': [7, 14, 26, 29, 36, 45, 92, 106, 137, 142, 146], 'their': [8], 'metabolites': [9], 'ceramide': [10], '(Cer),': [11], 'sphingosine': [12, 87], '(Sph),': [13], 'sphingosine-1-phosphate': [15], '(S1P)': [16], 'have': [17], 'important': [18], 'physiological': [19], 'functions,': [20], 'including': [21], 'regulation': [22, 136], 'growth': [25, 34], 'survival.': [27], 'Cer': [28, 44], 'Sph': [30, 81], 'associated': [32, 52], 'with': [33, 53], 'arrest': [35], 'apoptosis.': [37], 'Many': [38], 'stress': [39], 'stimuli': [40], 'increase': [41], 'levels': [42, 56, 108], 'Sph,': [46], 'whereas': [47], 'suppression': [48], 'apoptosis': [50, 145], 'is': [51, 76, 115, 123], 'increased': [54], 'intracellular': [55], 'S1P.': [58], 'In': [59], 'addition,': [60], 'extracellular/secreted': [61], 'S1P': [62, 75, 105, 143], 'regulates': [63], 'cellular': [64], 'processes': [65], 'by': [66, 78, 83], 'binding': [67], 'to': [68], 'five': [69], 'specific': [70], 'G': [71], 'protein': [72], 'coupled-receptors': [73], '(GPCRs).': [74], 'generated': [77], 'phosphorylation': [79], 'catalyzed': [82], 'two': [84], 'isoforms': [85], 'kinases': [88], '(SphK),': [89], 'type': [90, 93], '1': [91], '2,': [94], 'which': [95], 'critical': [97], 'regulators': [98], 'the': [100, 130, 135, 138], '"sphingolipid': [101], 'rheostat",': [102], 'producing': [103], 'pro-survival': [104], 'decreasing': [107], 'pro-apoptotic': [110], 'Sph.': [111], 'Since': [112], 'sphingolipid': [113], 'metabolism': [114], 'often': [116], 'dysregulated': [117], 'in': [118, 144], 'many': [119], 'diseases,': [120], 'targeting': [121], 'SphKs': [122, 141], 'potentially': [124], 'clinically': [125], 'relevant.': [126], 'Here': [127], 'we': [128], 'review': [129], 'growing': [131], 'recent': [132], 'literature': [133], 'on': [134], 'roles': [139], 'diseases.': [147]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2031449170', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 18}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 19}, {'year': 2017, 'cited_by_count': 32}, {'year': 2016, 'cited_by_count': 19}, {'year': 2015, 'cited_by_count': 22}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 34}, {'year': 2012, 'cited_by_count': 34}], 'updated_date': '2024-09-10T16:25:50.042324', 'created_date': '2016-06-24'}