Publication Information

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248], '1B1,': [13, 250], 'respectively)': [14, 251], 'are': [15, 26, 51, 149, 252, 263, 288, 386, 717, 725, 1106, 1750, 1762, 2265, 2513, 3197, 3323, 3337, 3410, 3911, 3996, 4049, 4491, 4617, 4905, 4913], 'regulated': [16, 253], 'by': [17, 84, 254, 321, 492, 611, 1033, 1572, 1613, 1754, 1766, 2541, 3495, 4680, 4799, 5221], 'the': [18, 90, 117, 126, 144, 154, 195, 212, 223, 226, 255, 327, 354, 363, 381, 391, 432, 449, 460, 463, 478, 549, 606, 655, 720, 799, 810, 813, 818, 830, 836, 856, 861, 915, 941, 955, 961, 969, 985, 1014, 1018, 1024, 1060, 1158, 1183, 1192, 1221, 1229, 1247, 1254, 1307, 1313, 1315, 1327, 1395, 1524, 1620, 1629, 1645, 1682, 1698, 1725, 1760, 1779, 1790, 1825, 1858, 1877, 1904, 1945, 1988, 2141, 2176, 2198, 2296, 2311, 2379, 2394, 2400, 2487, 2525, 2529, 2639, 2734, 2791, 3056, 3066, 3138, 3147, 3170, 3176, 3181, 3193, 3237, 3404, 3415, 3474, 3489, 3516, 3547, 3608, 3642, 3647, 3679, 3697, 3803, 3814, 3827, 3839, 3842, 3928, 4053, 4124, 4193, 4196, 4212, 4217, 4223, 4247, 4280, 4288, 4299, 4312, 4362, 4525, 4530, 4568, 4623, 4627, 4666, 4737, 4794, 4843, 4908, 4987, 4998, 5001, 5006, 5018, 5024, 5044, 5049, 5103, 5129, 5143, 5149, 5157, 5173, 5202, 5206, 5212], 'aromatic': [19, 36, 40, 256, 273, 277, 505, 514, 525, 2218, 2645, 4693, 4702, 4713], 'hydrocarbon': [20, 257, 526, 625, 4714, 4813], 'receptor': [21, 258, 882, 5070], '(AHR).': [22, 259], 'CYP1': [24, 49, 65, 179, 207, 227, 261, 286, 302, 416, 444, 464, 922, 1052, 1071, 1095, 1136, 1186, 1201, 1207, 1223, 1285, 1429, 1508, 2617, 2921, 4040, 4095, 4199, 4316, 4375, 4404, 4486, 5110], 'enzymes': [25, 50, 134, 148, 228, 262, 287, 371, 385, 465, 613, 1430, 3885, 3937, 4075, 4080, 4106, 4110, 4376, 4405, 4487, 4801], 'responsible': [27, 264, 871, 1710, 2557, 3232, 3997, 5059], 'for': [28, 48, 186, 265, 285, 423, 653, 802, 872, 1567, 1711, 2295, 2558, 2638, 3199, 3211, 3233, 3944, 3970, 3998, 4544, 4841, 4990, 5060], 'both': [29, 266, 850, 4114, 5038], 'metabolically': [30, 267], 'activating': [31, 268], 'detoxifying': [33, 270], 'numerous': [34, 271, 2334, 4545], 'polycyclic': [35, 272, 504, 513, 4692, 4701], 'hydrocarbons': [37, 274, 506, 4694], '(PAHs)': [38, 275, 507, 4695], 'amines': [41, 278, 2221], 'present': [42, 279, 3790], 'in': [43, 55, 64, 77, 89, 97, 125, 130, 143, 153, 209, 229, 235, 280, 292, 301, 314, 326, 334, 362, 367, 380, 390, 446, 466, 472, 477, 497, 561, 812, 849, 889, 924, 965, 1041, 1056, 1100, 1113, 1157, 1236, 1268, 1295, 1369, 1376, 1379, 1385, 1392, 1625, 1633, 1756, 1763, 1774, 1799, 1822, 1845, 1939, 1994, 1999, 2002, 2111, 2136, 2148, 2156, 2223, 2246, 2255, 2268, 2300, 2308, 2324, 2331, 2369, 2399, 2404, 2429, 2438, 2484, 2656, 2675, 2680, 2695, 2731, 2788, 2830, 3008, 3046, 3060, 3065, 3084, 3141, 3219, 3236, 3414, 3430, 3463, 3473, 3497, 3515, 3546, 3556, 3617, 3694, 3802, 3809, 3838, 3890, 3919, 3925, 4028, 4052, 4061, 4067, 4192, 4200, 4257, 4265, 4278, 4290, 4294, 4300, 4309, 4346, 4352, 4361, 4408, 4478, 4515, 4565, 4621, 4640, 4653, 4665, 4685, 4749, 5000, 5037, 5077, 5112, 5153, 5229], 'combustion': [44, 281], 'products.': [45, 282], 'Many': [46, 283, 2509], 'substrates': [47, 284, 3340], 'AHR': [52, 56, 92, 106, 205, 224, 289, 293, 329, 343, 442, 461, 862, 918, 944, 988, 996, 1065, 1370, 1397, 1405, 1458, 1686, 2578, 2640, 2672, 2693, 2736, 3194, 4563, 5050, 5106, 5132, 5176, 5184], 'ligands.': [53, 290], 'Differences': [54, 291], 'affinity': [57, 93, 294, 330, 874, 879, 917, 943, 987, 995, 1064, 1393, 1517, 1540, 1622, 5062, 5067, 5105, 5131, 5175, 5183], 'between': [58, 295, 1134, 1220, 1246, 1944, 2271], 'inbred': [59, 296, 714, 2800, 4902], 'mouse': [60, 200, 214, 297, 437, 451, 715, 821, 1061, 2792, 2822, 2916, 3006, 3481, 3681, 3699, 4510, 4526, 4532, 4558, 4569, 4615, 4628, 4643, 4648, 4903, 5009], 'strains': [61, 298, 716, 2801, 4904], 'reflect': [62, 299], 'variations': [63, 300], 'inducibility': [66, 303, 1072, 1096, 1137, 1187, 1202, 1224, 1249], 'clearly': [68, 305], 'have': [69, 121, 306, 358, 621, 1180, 1910, 2208, 2287, 2315, 2435, 2491, 2496, 2817, 3041, 4306, 4366, 4512, 4540, 4809], 'been': [70, 307, 1690, 1706, 2210, 2288, 2316, 2436, 2492, 2498, 2818, 3856, 4307, 4513, 4574], 'shown': [71, 122, 308, 359, 578, 933, 1133, 2291, 2499, 3684, 4766, 5121], 'to': [72, 105, 220, 233, 309, 342, 457, 470, 485, 502, 547, 558, 582, 587, 592, 620, 637, 660, 665, 719, 774, 809, 926, 934, 945, 998, 1191, 1373, 1433, 1708, 1721, 1909, 2293, 2318, 2471, 2504, 2554, 2926, 3040, 3136, 3146, 3189, 3230, 3327, 3460, 3791, 3914, 4015, 4204, 4209, 4227, 4296, 4298, 4379, 4524, 4673, 4690, 4735, 4746, 4770, 4775, 4780, 4808, 4825, 4848, 4853, 4907, 4962, 4997, 5114, 5122, 5133, 5186], 'be': [73, 310, 503, 548, 559, 775, 935, 1031, 1617, 1642, 1709, 2147, 2165, 2555, 3231, 3691, 3849, 4083, 4112, 4116, 4121, 4275, 4283, 4323, 4380, 4638, 4651, 4691, 4736, 4747, 4963, 5123, 5219], 'associated': [74, 311, 1461, 1864, 1902, 2514], 'with': [75, 312, 742, 796, 817, 968, 1239, 1243, 1355, 1462, 1619, 1679, 1723, 1865, 1876, 1903, 2151, 2320, 2515, 3428, 3509, 3607, 3858, 4485, 4930, 4984, 5005, 5156], 'differences': [76, 96, 313, 333, 870, 1368, 1844, 2267, 2299, 2428, 5058], 'risk': [78, 99, 315, 336, 992, 1867, 4655, 5180], 'of': [79, 100, 116, 138, 156, 188, 198, 211, 316, 337, 353, 375, 393, 425, 435, 448, 608, 657, 668, 787, 929, 954, 1013, 1059, 1069, 1185, 1228, 1253, 1290, 1309, 1360, 1394, 1428, 1507, 1523, 1535, 1555, 1578, 1743, 1759, 1778, 1784, 1789, 1857, 1868, 2193, 2197, 2204, 2302, 2378, 2385, 2510, 2524, 2528, 2536, 2614, 3052, 3058, 3149, 3179, 3422, 3470, 3477, 3488, 3549, 3644, 3649, 3652, 3805, 3817, 3830, 3841, 3878, 3931, 4071, 4198, 4219, 4225, 4242, 4246, 4315, 4384, 4500, 4567, 4658, 4796, 4845, 4856, 4975, 5117, 5142, 5201], 'toxicity': [80, 101, 317, 338, 953, 1002, 2205, 2928, 3062, 3235, 3333, 3740, 3797, 3819, 3832, 4206, 4259, 4270, 4412, 4659, 5141, 5190], 'or': [81, 102, 114, 129, 140, 191, 206, 318, 339, 351, 366, 377, 428, 443, 886, 1001, 1009, 1232, 1258, 1527, 1532, 1951, 2115, 2138, 2206, 2705, 3798, 3808, 3873, 3902, 3933, 4019, 4025, 4089, 4118, 4268, 4337, 4349, 4354, 4632, 5074, 5189, 5197], 'cancer': [82, 103, 319, 340, 475, 1074, 1227, 1252, 1522, 1546, 1993, 2207, 4414, 4663], 'caused': [83, 320, 4411], 'PAHs': [85, 139, 322, 376, 556, 639, 783, 887, 2335, 4744, 4827, 4971, 5075], 'arylamines.': [87, 324], 'Variability': [88, 325], 'human': [91, 98, 204, 230, 328, 335, 441, 467, 1103, 1380, 1396, 1646, 1826, 2161, 2250, 2312, 2405, 2439, 2488, 2735, 3490, 4520, 4562, 4624, 4634], 'exists,': [94, 331], 'but': [95, 332, 1402, 2109, 2134, 3048], 'related': [104, 341], 'activation': [107, 137, 344, 374, 3487, 4203], 'remain': [108, 345], 'unproven.': [109, 346], 'Mouse': [110, 347, 3071, 4505], 'lines': [111, 348, 4511, 4539, 4616, 4649], 'having': [112, 349, 914, 940, 984, 5102, 5128, 5172], 'one': [113, 217, 350, 454, 2328, 4119], 'another': [115, 352], 'Cyp1': [118, 355], 'disrupted': [120, 357], 'paradoxical': [123, 360, 3484, 3603, 4054], 'effects;': [124, 361], 'test': [127, 170, 364, 407], 'tube': [128, 365], 'cell': [131, 368, 616, 2696, 2703, 3069, 4232, 4804], 'culture': [132, 369, 1114, 3085], 'these': [133, 147, 370, 384, 2511, 3202, 3215, 3793, 4517, 4538], 'show': [135, 221, 372, 458, 3512], 'metabolic': [136, 159, 373, 396], 'arylamines,': [141, 378, 2342], 'whereas': [142, 379, 723, 1537, 3400, 3837, 4058, 4911], 'intact': [145, 382, 3238, 3843, 4194, 4363], 'animal': [146, 162, 383, 399, 4195], 'sometimes': [150, 387], 'more': [151, 388, 780, 936, 1197, 1212, 1549, 1693, 4493, 4633, 4968, 5124], 'important': [152, 389, 2538, 4519, 4652], 'role': [155, 392, 3057, 3853, 4197], 'detoxification': [157, 394, 562, 3921, 4201, 4385, 4750], 'than': [158, 395, 782, 938, 993, 1213, 1550, 1694, 3923, 4495, 4970, 5126, 5181], 'potentiation.': [160, 397], 'Intact': [161, 398], 'data': [163, 400, 825, 4292, 4305, 5013], 'contradict': [164, 401], 'pharmaceutical': [165, 402], 'company': [166, 403], 'policies': [167, 404], 'that': [168, 222, 234, 405, 459, 471, 481, 554, 579, 628, 748, 835, 863, 883, 1182, 1324, 1514, 1644, 1688, 1934, 2522, 2584, 2701, 3205, 3225, 3336, 3429, 3457, 3907, 4009, 4081, 4253, 4326, 4338, 4403, 4409, 4669, 4742, 4767, 4816, 4936, 5023, 5051, 5071], 'routinely': [169, 406], 'drugs': [171, 408, 2214, 3335], 'under': [172, 409, 4249, 4619], 'development;': [173, 410], 'if': [174, 411, 3786], 'a': [175, 203, 412, 440, 486, 666, 1094, 1214, 1389, 1515, 1538, 1850, 2152, 2166, 2580, 2784, 3208, 4372, 4561, 4642, 4674, 4854], 'candidate': [176, 413, 2167], 'drug': [177, 414], 'shows': [178, 415, 2361, 3483], 'inducibility,': [180, 417], 'further': [181, 418, 4359], 'testing': [182, 419], 'is': [183, 216, 420, 453, 964, 1021, 1459, 1511, 1718, 1739, 1771, 1863, 1941, 2170, 2253, 2367, 2462, 2466, 2469, 2579, 2702, 2924, 3207, 3228, 3788, 3800, 3813, 3826, 3905, 4007, 4011, 4023, 4039, 4064, 4207, 4255, 5152, 5209], 'generally': [184, 421, 1189, 4492], 'discontinued': [185, 422], 'fear': [187, 424], 'possible': [189, 426, 1513, 3906, 4008], 'toxic': [190, 427, 1010, 5198], 'carcinogenic': [192, 429], 'effects.': [193, 430, 3688], 'In': [194, 431, 981, 2131, 3865, 3898, 3927, 4003, 4303, 5169], 'future,': [196, 433], 'use': [197, 434], '“humanized”': [199, 436, 4647], 'lines,': [201, 438], 'containing': [202, 439, 4560], 'allele': [208, 445], 'place': [210, 447, 4566], 'orthologous': [213, 450, 4531, 4629], 'gene,': [215, 452, 838, 858, 1828, 5026, 5046], 'likely': [218, 455, 3229, 4037, 4208], 'approach': [219, 456], 'behave': [231, 468], 'similarly': [232, 469], 'mouse.': [236, 473], 'IntroductionClassical': [474, 4662], 'studies': [476, 1932, 2196, 3455, 4547, 4657, 4664], '1930s': [479, 4667], 'showed': [480, 1205, 1933, 3204, 4668], 'coal': [482, 498, 4670, 4686], 'tar': [483, 499, 4671, 4687], 'applied': [484, 4672], "rabbit's": [487, 4675], 'ear': [488, 4676], 'causes': [489, 3499, 4677], 'papillomas': [490, 4678], 'followed': [491, 4679], 'tumors.': [493, 4681], 'active': [495, 4683], 'ingredients': [496, 4684], 'were': [500, 618, 794, 832, 931, 989, 1997, 3134, 3166, 3217, 3386, 3605, 4377, 4406, 4522, 4688, 4806, 4982, 5020, 5119, 5177], 'determined': [501, 1571, 4689], '1The': [508, 4696], 'abbreviations': [509, 4697], 'used': [510, 3135, 4698], 'are:': [511, 4699], 'PAH,': [512, 4700], 'hydrocarbon;': [515, 4703], 'BaP,': [516, 4704], 'benzo[a]pyrene;': [517, 4705], 'B6,': [518, 4706], 'C57BL/6;': [519, 4707], 'D2,': [520, 4708], 'DBA/2;': [521, 4709], 'TCDD,': [522, 4710], '2,3,7,8-tetrachlorodibenzo-p-dioxin;': [523, 4711], 'AHR,': [524, 3180, 4712], 'receptor;': [527, 4715], 'IQ,': [528, 4716], '2-amino-3-methylimidazo[4,5f]quinoline;': [529, 4717], 'PhIP,': [530, 4718], '2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine;': [531, 4719], 'ABP,': [532, 4720], '4-aminobiphenyl;': [533, 4721], 'DMBA,': [534, 4722], '7,12-dimethylbenzo[a]anthracene).': [535, 4723], 'such': [536, 1305, 2235, 3132, 3686, 4724], 'as': [537, 753, 784, 1004, 1306, 2227, 2236, 2336, 2338, 3129, 3169, 4237, 4239, 4725, 4941, 4972, 5192], 'benzo[a]pyrene': [538, 4726], '(BaP).': [539, 4727], 'parent': [541, 4729], 'PAH': [542, 661, 721, 963, 1034, 4335, 4730, 4849, 4909, 5151, 5222], 'at': [543, 776, 990, 1312, 2480, 2727, 3150, 4731, 4964, 5178], 'first': [544, 2401, 4732], 'was': [545, 576, 614, 750, 772, 806, 1098, 1132, 1188, 1317, 1398, 1570, 1650, 1702, 1907, 3063, 3223, 3554, 4371, 4733, 4764, 4802, 4938, 4960, 4994], 'thought': [546, 557, 4378, 4734, 4745], 'carcinogen': [550, 3493, 4738], 'an': [552, 754, 785, 844, 1130, 2516, 2537, 3876, 4740, 4942, 4973, 5032], 'enzyme': [553, 1286, 1700, 1748, 2325, 2507, 4041, 4741], 'metabolized': [555, 581, 1765, 4743, 4769], 'beneficial': [560, 4382, 4748], '(1Wattenberg': [563, 4386, 4751], 'L.W.': [564, 4387, 4752], 'Leong': [565, 4388, 4753], 'J.L.': [566, 4389, 4754], 'Strand': [567, 4390, 4755], 'P.J.': [568, 4391, 4756], 'Cancer': [569, 1054, 1172, 1892, 1923, 1965, 2047, 3539, 3990, 4181, 4392, 4468, 4757], 'Res.': [570, 1173, 1893, 1924, 1966, 1979, 2091, 3256, 3779, 4182, 4393, 4469, 4758], '1962;': [571, 4394, 4759], '22:': [572, 2106, 4395, 4760], '1120-1125Google': [573, 4396, 4761], 'Scholar).': [574, 650, 737, 767, 980, 1154, 1425, 1456, 1818, 1897, 1984, 2130, 2191, 2356, 2551, 2636, 2670, 2691, 2724, 2913, 3003, 3122, 3164, 3382, 3452, 3601, 3784, 4397, 4473, 4556, 4608, 4762, 4838, 4925, 4955, 5168, 5239], 'It': [575, 1510, 4763], 'subsequently': [577, 932, 4765, 5120], 'PAHs,': [580, 2643, 4768], 'reactive': [583, 4098, 4771], 'intermediates,': [584, 4772], 'bind': [585, 4773], 'covalently': [586, 4774], 'nucleic': [588, 4776], 'acids': [589, 4777], 'proteins': [591, 4779], 'form': [593, 4781], 'adducts': [594, 3409, 3458, 3502, 3514, 3616, 4782], '(2Grover': [595, 4415, 4783], 'P.L.': [596, 4416, 4784], 'Sims': [597, 4417, 4785], 'P.': [598, 1601, 2834, 3576, 3663, 4418, 4786], 'Biochem.': [599, 708, 732, 1451, 1813, 1977, 2631, 2719, 3117, 3254, 4153, 4419, 4787, 4896, 4920], 'J.': [600, 644, 1122, 1149, 1348, 1590, 1594, 1671, 1887, 1891, 1918, 1922, 2089, 2180, 2758, 2766, 2873, 2898, 2961, 2991, 3303, 3537, 3720, 3988, 4420, 4788, 4832], '1968;': [601, 647, 4421, 4789, 4835], '110:': [602, 4422, 4790], '159-160Google': [603, 4423, 4791], 'Scholar);': [604, 1928, 3965, 4792], 'thus,': [605, 4793], 'concept': [607, 4795], '“metabolic': [609, 4797], 'activation”': [610, 4798], 'PAH-metabolizing': [612, 4800], 'born.Mammalian': [615, 4803], 'cultures': [617, 4805], 'found': [619, 1181, 1218, 1375, 1399, 1998, 2222, 2654, 4807], 'BaP': [622, 788, 841, 1714, 1727, 1846, 1912, 1936, 2396, 3188, 3212, 3389, 3453, 3471, 3945, 4810, 4976, 5029], 'hydroxylase': [623, 1715, 1728, 1847, 1913, 1937, 2397, 4811], '(aryl': [624, 4812], 'hydroxylase)': [626, 4814], 'activity': [627, 1287, 1294, 1701, 1729, 1749, 1770, 1914, 1938, 2244, 2326, 2398, 4815], 'becomes': [629, 4817], 'highly': [630, 4818], 'induced': [631, 1284, 4819], 'within': [632, 3397, 4820], '12–24': [633, 4821], 'h': [634, 1109, 4822], 'upon': [635, 4823], 'exposure': [636, 4824], 'various': [638, 2202, 2383, 4136, 4826], '(3Nebert': [640, 4828], 'D.W.': [641, 678, 697, 728, 759, 892, 973, 1044, 1076, 1271, 1346, 1440, 1485, 1802, 2119, 2274, 2544, 2546, 2620, 2708, 2846, 3087, 3106, 3253, 3276, 3354, 3446, 3536, 3594, 3959, 3987, 4142, 4160, 4426, 4435, 4448, 4829, 4866, 4885, 4916, 4947, 5080, 5161, 5232], 'Gelboin': [642, 729, 3372, 4830, 4917], 'H.V.': [643, 730, 3373, 4831, 4918], 'Biol.': [645, 899, 908, 1278, 1420, 1500, 1672, 2126, 2281, 2415, 2602, 2686, 2747, 4167, 4442, 4833, 5087, 5096], 'Chem.': [646, 907, 1419, 1673, 2414, 2601, 2685, 2746, 3635, 3778, 4834, 5095], '243:': [648, 4836], '6242-6249Google': [649, 4837], 'This': [651, 1027, 3851, 4839, 5215], 'paradigm': [652, 1066, 4840], 'studying': [654, 4842], 'response': [656, 925, 4844, 5113], 'cultured': [658, 4846], 'cells': [659, 1783, 1788, 3073, 3125, 3807, 3901, 4005, 4847], 'treatment': [662, 4850], 'has': [663, 843, 867, 3682, 3854, 4482, 4572, 4851, 5031, 5055], 'led': [664, 3145, 4852], 'wealth': [667, 4855], 'knowledge': [669, 1680, 4857], 'concerning': [670, 4858], 'transcription,': [671, 4859], 'translation,': [672, 4860], 'signal': [674, 4862], 'transduction': [675, 4863], 'pathways': [676, 4864], '(4Nebert': [677, 972, 3086, 4865, 5160], 'Crit.': [679, 974, 1045, 3088, 4427, 4867, 5162, 5233], 'Rev.': [680, 689, 975, 1046, 2592, 2664, 3089, 3098, 3158, 4428, 4552, 4868, 4877, 5163, 5234], 'Toxicol.': [681, 691, 976, 1047, 2453, 2571, 2594, 2666, 2759, 2939, 2998, 3090, 3100, 3160, 3595, 3636, 3755, 3780, 4429, 4869, 4879, 5164, 5235], '1989;': [682, 977, 1048, 3091, 4430, 4870, 5165, 5236], '20:': [683, 978, 1049, 3092, 3581, 4431, 4871, 5166, 5237], '153-174Google': [684, 979, 1050, 3093, 4432, 4872, 5167, 5238], 'Scholar,': [685, 695, 1354, 1970, 2014, 2054, 2095, 2598, 2752, 2764, 2857, 2886, 3094, 3104, 3365, 4158, 4171, 4178, 4424, 4433, 4446, 4465, 4873, 4883], '5Hankinson': [686, 3095, 4874], 'O.': [687, 2590, 3096, 3156, 4583, 4875], 'Annu.': [688, 2591, 2663, 3097, 3157, 4876], 'Pharmacol.': [690, 709, 1452, 1814, 2455, 2573, 2593, 2632, 2665, 2720, 2941, 3099, 3118, 3159, 3448, 3597, 3961, 4154, 4878, 4897], '1995;': [692, 2011, 2595, 2854, 3101, 3161, 4880], '35:': [693, 2596, 3102, 3162, 4554, 4881], '307-340Google': [694, 2597, 3103, 3163, 4882], '6Nebert': [696, 1801, 3105, 4884], 'Roe': [698, 1441, 1803, 2621, 2709, 3107, 4143, 4886], 'A.L.': [699, 1442, 1804, 2622, 2710, 3108, 4144, 4887], 'Dieter': [700, 1443, 1805, 2623, 2711, 3109, 3242, 4145, 4888], 'M.Z.': [701, 1444, 1806, 2624, 2712, 3110, 3243, 4146, 4889], 'Solis': [702, 1445, 1807, 2625, 2713, 3111, 4147, 4890], 'W.A.': [703, 1446, 1808, 2626, 2714, 3112, 4148, 4891], 'Yang': [704, 1447, 1809, 2627, 2715, 3113, 4149, 4892], 'Y.': [705, 1448, 1810, 2036, 2058, 2628, 2716, 2888, 2890, 2894, 2900, 2951, 2953, 2957, 2963, 2983, 2985, 2987, 2995, 3015, 3029, 3031, 3114, 3522, 3973, 4150, 4589, 4595, 4893], 'Dalton': [706, 1449, 1482, 1811, 2629, 2717, 3115, 3435, 3523, 3589, 3948, 3974, 4151, 4894], 'T.P.': [707, 1450, 1483, 1812, 2630, 2718, 3116, 3241, 3436, 3524, 3590, 3949, 3975, 4152, 4895], '2000;': [710, 1453, 1733, 1815, 2353, 2633, 2721, 2770, 2883, 2910, 2973, 3119, 3258, 4155, 4175, 4898], '59:': [711, 1454, 1816, 2634, 2722, 3120, 4156, 4899], '65-85Google': [712, 1455, 1817, 2635, 2723, 3121, 4157, 4900], 'Scholar).Some': [713, 4901], '“sensitive”': [718, 4906], 'inducer,': [722, 4910], 'others': [724, 4912], 'not': [726, 1320, 1942, 2110, 2135, 3049, 3683, 3789, 3855, 4012, 4065, 4274, 4350, 4914], '(7Nebert': [727, 4915], 'Arch.': [731, 4919], 'Biophys.': [733, 1978, 3255, 4921], '1969;': [734, 4922], '134:': [735, 4923], '76-89Google': [736, 4924], 'Breeding': [738, 4926], 'sensitive': [739, 819, 4927, 5007], 'C57BL/6': [740, 4928], '(B6)': [741, 4929], 'resistant': [743, 814, 2925, 3130, 4931, 5002], 'DBA/2': [744, 4932], '(D2)': [745, 4933], 'mice': [746, 793, 939, 983, 997, 3322, 3330, 3385, 3395, 3402, 3432, 3465, 3507, 4934, 4981, 5127, 5171, 5185], 'revealed': [747, 4935], 'resistance': [749, 4937], 'inherited': [751, 4939], 'largely': [752, 2556, 4940], 'autosomal': [755, 4943], 'recessive': [756, 4944], 'trait': [757, 4945], '(8Nebert': [758, 4946], 'Gielen': [760, 4948], 'J.E.': [761, 4949], 'Fed.': [762, 4950], 'Proc.': [763, 2876, 2903, 2966, 3277, 3310, 3355, 3727, 4598, 4951], '1972;': [764, 4952], '31:': [765, 4953], '1315-1325Google': [766, 4954], 'When': [768, 3383, 4956], '2,3,7,8-tetrachlorodibenzo-p-dioxin': [769, 4957], '(TCDD;': [770, 4958], 'dioxin)': [771, 4959], 'realized': [773, 4961], 'least': [777, 2305, 2481, 2728, 3151, 4965], '30,000': [778, 4966], 'times': [779, 4967], 'potent': [781, 4969], 'inducer': [786, 4974], 'hydroxylase,': [789, 842, 4977, 5030], 'B6': [790, 820, 851, 1623, 4978, 5008, 5039], 'D2': [792, 815, 853, 4980, 5003, 5041], 'treated': [795, 3508, 4983], 'dioxin,': [797, 2642, 4985], 'effective': [800, 4988], 'dose': [801, 4989], '50%': [803, 4991], 'induction': [804, 1427, 1753, 4992], '(ED50)': [805, 4993], 'shifted': [807, 4995], '∼15-fold': [808, 4996], 'right': [811, 4999], 'compared': [816, 1242, 1678, 3427, 5004], '(Fig.': [822, 1194, 1400, 3886, 5010], '1).': [823, 5011], 'These': [824, 3165, 4285, 5012], '(proven': [826, 5014], 'years': [827, 1534, 5015], 'later': [828, 1110, 5016], 'when': [829, 960, 1017, 1874, 4374, 5017, 5148, 5205], 'cloned)': [833, 5021], 'suggested': [834, 3456, 5022], 'Cyp1a1': [837, 5025], 'which': [839, 859, 3144, 4516, 4622, 5027, 5047], 'encodes': [840, 860, 5028, 5048], 'identical': [845, 5033], 'amino': [846, 868, 2343, 5034, 5056], 'acid': [847, 869, 5035, 5057], 'sequence': [848, 5036], 'mice;': [854, 5042], 'however,': [855, 1929, 3392, 4357, 5043], 'Ahr': [857, 2793, 4570, 5045], 'regulates': [864, 5052], 'CYP1A1': [865, 1704, 1724, 1737, 1744, 1769, 1827, 2177, 2199, 3053, 3059, 3186, 3206, 3227, 3812, 3845, 3908, 3932, 4046, 4254, 4329, 5053], 'induction,': [866, 5054], 'high': [873, 916, 994, 1062, 1070, 1135, 1206, 1222, 1248, 1621, 1630, 2368, 3042, 3461, 4051, 4066, 5061, 5104, 5182], '(in': [875, 880, 2457, 5063, 5068], 'B6)': [876, 5064], 'poor': [878, 942, 986, 5066, 5130, 5174], 'D2)': [881, 5069], 'binds': [884, 5072], 'dioxin': [885, 5073], '(reviewed': [888, 1040, 1267, 1798, 5076, 5228], 'Refs.': [890, 5078], '10Nebert': [891, 1270, 4159, 4434, 5079], 'McKinnon': [893, 1272, 2120, 2275, 3267, 3345, 4161, 4436, 5081], 'R.A.': [894, 1273, 2121, 2276, 3268, 3346, 4162, 4437, 5082], 'Puga': [895, 1274, 1488, 2122, 2277, 3273, 3351, 4163, 4438, 5083], 'A.': [896, 1275, 1466, 1489, 1605, 1833, 2028, 2066, 2123, 2278, 2409, 2609, 2778, 2882, 2909, 2972, 3027, 3274, 3283, 3316, 3352, 3361, 3659, 3733, 3777, 4164, 4439, 4604, 5084], 'DNA': [897, 1276, 2124, 2279, 3615, 3821, 3834, 4165, 4440, 5085], 'Cell': [898, 1277, 2125, 2280, 4166, 4441, 5086], '1996;': [900, 1279, 1967, 2127, 2282, 2942, 3284, 3362, 3379, 4168, 4443, 5088], '15:': [901, 1280, 2128, 2283, 3782, 4169, 4444, 5089], '273-280Google': [902, 1281, 2129, 2284, 4170, 4445, 5090], 'Scholar': [903, 5091], '11Hahn': [905, 2599, 5093], 'M.E.': [906, 2444, 2600, 2684, 5094], 'Interact.': [909, 1421, 2416, 2603, 2687, 2748, 5097], '2002;': [910, 1422, 1502, 2548, 2604, 2688, 2749, 2813, 3000, 3035, 3598, 3637, 3781, 5098], '141:': [911, 1423, 2605, 2689, 2750, 5099], '131-160Google': [912, 2606, 2690, 5100], 'Scholar).Mice': [913, 5101], '(and': [919, 2431, 5107], 'therefore': [920, 2146, 5108], 'higher': [921, 3413, 5109], 'levels': [923, 1742, 2301, 2434, 3045, 3462, 5111], 'lower': [927, 3468, 5115], 'doses': [928, 5116], 'PAHs)': [930, 5118], 'prone': [937, 5125], 'PAH-induced': [946, 2559, 5134], 'cancers,': [947, 5135], 'mutagenesis,': [948, 5136], 'birth': [949, 5137], 'defects,': [950, 5138], 'uroporphyria,': [951, 5139], 'liver,': [956, 2256, 3418, 3618, 5144], 'eye,': [957, 5145], 'ovary': [959, 5147], 'administered': [962, 5150], 'direct': [966, 1237, 5154], 'contact': [967, 1238, 5155], 'target': [970, 1019, 4244, 5158, 5207], 'organ': [971, 1020, 5159, 5208], 'contrast,': [982, 5170], 'greater': [991, 5179], 'developing': [999, 4641, 5187], 'malignancy': [1000, 5188], '(such': [1003, 2226, 5191], 'immunosuppression,': [1005, 5193], 'immune': [1006, 4004, 4068, 5194], 'system': [1007, 5195], 'malignancy,': [1008, 5196], 'chemical': [1011, 4248, 5199], 'depression': [1012, 5200], 'bone': [1015, 5203], 'marrow)': [1016, 5204], 'distant': [1022, 1262, 5210], 'from': [1023, 1263, 1299, 1331, 1358, 1559, 2175, 2798, 3334, 3693, 4318, 5211], 'incoming': [1025, 1264, 5213], 'PAH.': [1026, 5214], 'seeming': [1028, 5216], 'paradox': [1029, 5217], 'can': [1030, 1431, 3848, 4082, 4111, 4115, 4120, 4322, 5218], 'explained': [1032, 5220], 'pharmacokinetics,': [1035, 5223], 'called': [1036, 5224], '“first-pass': [1037, 5225], 'elimination”': [1038, 5226], 'kinetics': [1039, 5227], 'Ref.': [1042, 1269, 1332, 1800, 5230], '4Nebert': [1043, 4425, 5231], 'Scholar).PAH-induced': [1051], 'Studies': [1055], 'HumansFollowing': [1057], 'reports': [1058], 'affinity/low': [1063], 'relationship': [1068], '(12Nebert': [1075], 'Benedict': [1077, 4449], 'W.F.': [1078, 1670, 4450], 'Kouri': [1079, 4451], 'R.E.': [1080, 1161, 4452], "Ts'o": [1081, 4453], 'P.O.P.': [1082, 4454], 'DiPaolo': [1083, 4455], 'J.A.': [1084, 4456], 'Chemical': [1085, 4457], 'Carcinogenesis.': [1086, 1732, 2010, 2104, 2352, 3034, 3579, 3672, 4174, 4458], 'Marcel': [1087, 4459], 'Dekker,': [1088, 4460], 'Inc.,': [1089, 4461], 'New': [1090, 4462], 'York1974:': [1091, 4463], '271-288Google': [1092, 4464], 'Scholar),': [1093, 1128, 1177, 2285, 2607, 2945, 2976, 3261, 3287, 3737, 3760], 'assay': [1097, 1159, 1323], 'developed': [1099, 1691, 4514], 'mitogen-activated': [1101, 1296], 'PAH-treated': [1102], 'lymphocytes': [1104, 1298], '(which': [1105], 'transformed': [1107], '55': [1108], 'into': [1111], 'lymphoblasts)': [1112], '(13Kellermann': [1115], 'G.': [1116, 1142, 2087, 3532, 3592, 3983], 'Luyten-Kellermann': [1117, 1145], 'M.': [1118, 1146, 1591, 1831, 1976, 2005, 2007, 2871, 2892, 2955, 3023, 3033, 3534, 3566, 3627, 3657, 3985, 4597], 'Shaw': [1119, 1143], 'C.R.': [1120, 1144, 2570, 3307, 3724, 3752], 'Am.': [1121, 1347], 'Hum.': [1123, 1349], 'Genet.': [1124, 1350], '1973;': [1125, 1151], '25:': [1126], '327-331Google': [1127], 'association': [1131], 'bronchogenic': [1139], 'carcinoma': [1140], '(14Kellermann': [1141], 'N.': [1147, 1587, 2064, 2097, 2562, 3247, 4591], 'Engl.': [1148], 'Med.': [1150, 1501], '289:': [1152], '934-937Google': [1153], 'Following': [1155], 'improvements': [1156], '(15Kouri': [1160], 'McKinney': [1162, 1335], 'C.E.': [1163, 1336], 'Slomiany': [1164], 'D.J.': [1165], 'Snodgrass': [1166], 'D.R.': [1167, 2811], 'Wray': [1168], 'N.P.': [1169], 'McLemore': [1170], 'T.L.': [1171], '1982;': [1174, 1472], '42:': [1175], '5030-5037Google': [1176], 'many': [1178, 1758, 2216, 2339, 2390], 'laboratories': [1179, 1216, 2001], 'distribution': [1184], 'skewed': [1190], 'left': [1193], '2),': [1195], 'i.e.': [1196], 'individuals': [1198, 2272], 'displayed': [1199], 'low': [1200, 1610, 4024], 'fewer': [1204], 'inducibility.': [1208], 'Studying': [1209], 'cigarette': [1210, 1240, 1265, 1869, 1995, 2157], 'smokers,': [1211, 2474], 'dozen': [1215, 2587], 'independently': [1217], 'correlations': [1219], 'phenotype': [1225, 1250, 3140], 'lung,': [1230], 'larynx,': [1231], 'oral': [1233, 1525, 3388], 'cavity': [1234, 1526], '(tissues': [1235, 1261], 'smoke)': [1241, 1266], 'no': [1244, 1403, 1841, 2289], 'correlation': [1245], 'renal': [1255], 'pelvis,': [1256], 'ureter,': [1257], 'urinary': [1259, 3491, 3519], 'bladder': [1260, 3492, 3520], 'Scholar).Fig.': [1282], '2Maximally': [1283], 'per': [1288], 'unit': [1289], 'NADH-cytochrome': [1291], 'c': [1292], 'reductase': [1293], '3-methylcholanthrene-treated': [1297], '47': [1300], 'unrelated': [1301, 1387, 1561], 'individuals.': [1302], 'Environmental': [1303], 'factors,': [1304], 'number': [1308], 'cigarettes': [1310], 'smoked': [1311], 'time': [1314, 4373], 'blood': [1316, 1785], 'drawn,': [1318], 'do': [1319], 'influence': [1321], 'this': [1322, 1409, 3863, 4319], 'specifically': [1325], 'determines': [1326], 'CYP1-inducibility': [1328], 'phenotype.': [1329], '(Redrawn': [1330], '16Petersen': [1333], 'D.D.': [1334], 'Ikeya': [1337], 'K.': [1338, 1834, 1889, 1920, 2009, 2018, 2020, 2022, 2026, 2044, 2062, 2068, 2083, 2807, 3013, 3025, 3748], 'Smith': [1339], 'H.H.': [1340], 'Bale': [1341], 'A.E.': [1342], 'McBride': [1343], 'O.W.': [1344], 'Nebert': [1345, 1484, 2776, 2845, 3252, 3275, 3353, 3445, 3535, 3593, 3958, 3986], '1991;': [1351], '48:': [1352], '720-725Google': [1353], 'permission': [1356], 'obtained': [1357], 'University': [1359], 'Chicago': [1361], 'Press.)View': [1362], 'Large': [1363, 1636, 2426, 4187], 'Image': [1364, 1637, 4188], 'Figure': [1365, 1638, 4189], 'ViewerDownload': [1366, 1639, 4190], '(PPT)Do': [1367], 'affinity,': [1371], 'similar': [1372, 3552], 'those': [1374], 'mice,': [1377], 'exist': [1378], 'populations?': [1381], 'From': [1382], 'Kd': [1383, 1611], 'values': [1384], '115': [1386, 1560], 'subjects,': [1388], '>12-fold': [1390], 'variation': [1391, 1410], '3),': [1401], 'known': [1404, 1720], 'gene': [1406, 1648, 2163, 2178, 2252, 2314, 2490, 2673, 2737, 2794, 4571, 4625], 'polymorphism': [1407, 2200], 'explains': [1408], '(17Harper': [1411, 2738], 'P.A.': [1412, 2739], 'Wong': [1413, 2740], 'J.M.Y.': [1414, 2741], 'Lam': [1415, 2742], 'M.S.M.': [1416, 2743], 'Okey': [1417, 2744], 'A.B.': [1418, 2745], '161-187Google': [1424, 2751], 'AHR-mediated': [1426], 'lead': [1432], 'genotoxicity,': [1434], 'mutation,': [1435, 1900, 1906], 'tumor': [1437, 1463], 'initiation': [1438], '(6Nebert': [1439, 2619, 2707, 4141], 'also': [1460, 2209, 3482, 4637], 'promotion': [1464], '(18Poland': [1465], 'Palen': [1467], 'D.': [1468, 1584, 1837, 2101, 2103], 'Glover': [1469, 2868], 'E.': [1470, 2869, 3019], 'Nature.': [1471], '300:': [1473], '271-273Google': [1474], 'Scholar)': [1475, 1505, 1677, 2077, 2108, 2420, 2459, 2773, 2816, 3038, 3320, 3544, 3583, 3640], 'enhanced': [1477, 3500, 3891, 4029], 'oxidative': [1478, 3894, 3936, 4074], 'stress': [1479], '(19Senft': [1480], 'A.P.': [1481], 'Genter': [1486, 3250], 'M.B.': [1487, 3251], 'Hutchinson': [1490], 'R.J.': [1491], 'Kerzee': [1492], 'J.K.': [1493], 'Uno': [1494], 'S.': [1495, 1885, 1916, 2030, 2034, 2060, 2070, 2081, 2182, 2184, 2413, 2844, 2848, 2881, 2908, 2934, 2971, 3282, 3293, 3315, 3360, 3375, 3434, 3438, 3564, 3633, 3655, 3710, 3732, 3746, 3947, 3951, 4585, 4587, 4603], 'Shertzer': [1496, 3248, 3443, 3529, 3956, 3980], 'H.G.': [1497, 3249, 3444, 3530, 3588, 3957, 3981], 'Free': [1498], 'Radic.': [1499], '33:': [1503], '1268-1278Google': [1504], 'independent': [1506, 1931], 'activity.': [1509, 1716], 'thus': [1512], '“high': [1516], 'AHR”': [1518, 1541], 'patient': [1519, 1569], 'might': [1520, 1543, 2145, 2164, 2533, 3690, 3861, 4636], 'develop': [1521, 1545], 'lung': [1528, 1871, 1992, 2440], 'after': [1529, 1548], 'only': [1530, 2172, 3127], '20-': [1531], '40-pack': [1533], 'smoking,': [1536], '“poor': [1539], 'individual': [1542], 'never': [1544], 'even': [1547, 2679, 4528], '100-pack': [1551], 'years.Fig.': [1552], '3Probit': [1553], 'analysis': [1554, 1615], 'placenta': [1556], 'cytosolic': [1557], 'samples': [1558], 'patients.': [1562], 'dissociation': [1564], 'constant,': [1565], 'Kd,': [1566], 'each': [1568], 'Scatchard': [1573, 1614], 'plot': [1574], 'using': [1575, 4291], 'five': [1576], 'concentrations': [1577], 'radiolabeled': [1579], '[3H]TCDD': [1580], '(Renehan,': [1581], 'E.,': [1582], 'Manchester,': [1583], 'K.,': [1585], 'Parker,': [1586], 'B.,': [1588, 1606], 'Wong,': [1589], 'Y.,': [1592], 'Giannone,': [1593], 'V.,': [1595], 'Bush,': [1596], 'L.,': [1597, 1599], 'Endrenyi,': [1598], 'Harper,': [1600], 'A.,': [1602], 'Okey,': [1604, 2780], 'unpublished': [1607, 2781], 'data).': [1608], 'A': [1609, 3551, 4557], 'value': [1612], 'would': [1616, 3888], 'consistent': [1618], 'curve': [1624], 'Fig.': [1626, 1634], '1': [1627], 'CYP1/reductase': [1631], 'ratio': [1632], '2.View': [1635], '(PPT)It': [1640], 'should': [1641], 'noted': [1643], 'discovery': [1649, 3148], 'relatively': [1651], 'late': [1652], '(20Sutter': [1653], 'T.R.': [1654, 2452], 'Tang': [1655, 3368], 'Y.M.': [1656], 'Hayes': [1657], 'C.L.': [1658], 'Wo': [1659], 'Y.Y.': [1660], 'Jabs': [1661], 'E.W.': [1662], 'Li': [1663, 2039, 3265, 3343], 'X.': [1664], 'Yin': [1665], 'H.': [1666, 2016, 2024, 2896, 2959, 3266, 3344, 3570, 3661, 3773, 4579], 'Cody': [1667], 'C.W.': [1668], 'Greenlee': [1669], '1994;': [1674], '269:': [1675], '13092-13099Google': [1676], 'about': [1681], 'had': [1689, 1705], 'over': [1692], 'two': [1695, 1930], 'decades.': [1696], 'Before': [1697], 'characterized,': [1703], 'believed': [1707], 'virtually': [1712, 1775], 'all': [1713, 2615, 2676, 3393, 4400, 4479], 'now': [1719, 4618], 'share': [1722], 'PAH-inducible': [1726, 2254], '(21Guengerich': [1730, 2350], 'F.P.': [1731, 1962, 2351, 2448, 4173], '21:': [1734, 2354, 4176], '345-351Google': [1735, 2355, 4177], 'Scholar).CYP1A1Basal': [1736], 'expression': [1738, 2366, 2502, 2922], 'negligible.': [1740], 'High': [1741], 'mRNA,': [1745], 'protein,': [1746], 'detectable': [1751], 'following': [1752], 'PAHs;': [1755], 'fact,': [1757, 4279], 'inducers': [1761], 'turn': [1764], 'CYP1A1.': [1767, 3478], 'Inducible': [1768], 'ubiquitous,': [1772], 'located': [1773, 2171], 'every': [1776], 'tissue': [1777], 'body': [1780], 'including': [1781, 2612, 3079], 'endothelial': [1782, 2371], 'vessels,': [1786], 'epithelial': [1787, 2376, 3900], 'skin': [1791, 2948], 'gastrointestinal': [1793, 2257, 3416, 3899, 4043], 'tract,': [1794, 2258, 3417], 'fetus,': [1795], 'embryo': [1797], 'Of': [1819], '12': [1820], 'mutations': [1821, 2290, 2307, 2483, 2512, 2730, 2787], 'near': [1824, 2310, 2486, 2733, 2790], '2S.': [1829], 'Malmebo,': [1830], 'Ingelman-Sundberg,': [1832], 'Daly,': [1835], 'W.': [1838, 2099, 2775], 'Nebert,': [1839], 'www.imm.ki.se/CYPalleles.': [1840], 'variant': [1842], 'exhibits': [1843, 2823, 3700], 'activity.Among': [1848], 'Japanese,': [1849], 'mutated': [1851], 'MspI': [1852, 1905], 'site,': [1853], '450': [1854], 'bp': [1855], 'downstream': [1856], 'last': [1859], 'exon': [1860], '(CYP1A1*2A': [1861], 'allele),': [1862], 'increased': [1866, 1911, 3332, 3513, 3701], 'smoking-induced': [1870, 2158], 'cancer,': [1872], 'especially': [1873, 2655], 'combined': [1875, 4639], 'glutathione': [1878, 4131], 'S-transferase': [1879], 'mu': [1880], '(GSTM1*0)': [1881], 'null': [1882], 'mutation': [1883, 2154], '(23Hayashi': [1884, 1915], 'Watanabe': [1886, 1917], 'Kawajiri': [1888, 1919], 'Jpn.': [1890, 1921], '1992;': [1894, 1925], '83:': [1895, 1926], '866-870Google': [1896, 1927], 'An': [1898, 4035], 'I462V': [1899], 'often': [1901, 2360], 'reported': [1908, 2437, 2493, 4575], 'cDNA-expressed': [1935], 'vitro': [1940, 3498, 3695, 3810, 4295, 4304], 'different': [1943, 2153], 'CYP1A1*1': [1946], 'wild-type': [1947, 3431], 'CYP1A1*2A,': [1949], '*2B,': [1950], '*2C': [1952], 'allelic': [1953, 2143], 'products': [1954], '(24Zhang': [1955], 'Z.Y.': [1956], 'Fasco': [1957], 'M.J.': [1958], 'Huang': [1959], 'L.': [1960, 2085, 3631, 3769], 'Guengerich': [1961, 2447], 'Kaminsky': [1963], 'L.S.': [1964], '56:': [1968], '3926-3933Google': [1969], '25Persson': [1971], 'I.': [1972, 1974], 'Johansson': [1973], 'Ingelman-Sundberg': [1975], 'Commun.': [1980, 3257], '1997;': [1981], '231:': [1982], '227-230Google': [1983], 'Similar': [1985], 'associations': [1986], '(between': [1987], 'CYP1A1*2': [1989, 2142], 'alleles': [1990], 'smokers)': [1996], 'other': [2000, 2194, 2348, 2391, 3142, 3935, 4125], 'Japan': [2003, 3009], '(26Kihara': [2004], 'Kihara': [2006], 'Noda': [2008], '16:': [2012], '2331-2336Google': [2013], '27Sugimura': [2015], 'Wakai': [2017], 'Genka': [2019], 'Nagura': [2021], 'Igarashi': [2023], 'Nagayama': [2025], 'Ohkawa': [2027], 'Baba': [2029], 'Morris': [2031], 'B.J.': [2032], 'Tsugane': [2033], 'Ohno': [2035], 'Gao': [2037], 'C.': [2038, 2056, 2867, 4593], 'Z.': [2040], 'Takezaki': [2041], 'T.': [2042, 2046, 2072, 2836, 2840, 2902, 2965, 2989, 2997, 3011, 3017, 3021, 3295, 3297, 3371, 3712, 3714, 4577, 4581], 'Tajima': [2043], 'Iwamasa': [2045], 'Epidemiol.': [2048], 'Biomarkers': [2049], 'Prev.': [2050], '1998;': [2051, 2074, 2761], '7:': [2052], '413-417Google': [2053], '28Kiyohara': [2055], 'Nakanishi': [2057], 'Inutsuka': [2059], 'Takayama': [2061], 'Hara': [2063], 'Motohiro': [2065], 'Tanaka': [2067], 'Kono': [2069], 'Hirohata': [2071], 'Pharmacogenetics.': [2073, 2187, 2769, 2812, 3378], '8:': [2075], '315-323Google': [2076], 'China': [2079], '(29Chen': [2080], 'Xue': [2082], 'Xu': [2084], 'Ma': [2086], 'Wu': [2088], 'Mutat.': [2090], '2001;': [2092, 2105, 2188], '458:': [2093], '41-47Google': [2094], '30Song': [2096], 'Tan': [2098], 'Xing': [2100], 'Lin': [2102], '11-16Google': [2107], 'Caucasians,': [2112], 'African': [2113, 2139], 'Americans,': [2114], 'Eastern': [2116], 'Mediterraneans': [2117], '(10Nebert': [2118, 2273], 'Asian': [2132], 'populations': [2133], 'Caucasian': [2137], 'populations,': [2140], 'series': [2144], 'linkage': [2149], 'disequilibrium': [2150], 'involved': [2155], 'cancer.': [2159], 'CYP1A2': [2162, 2243, 2251, 2270, 2313, 3044, 3339, 3496, 3825, 3847, 3910, 4048, 4263, 4339], 'because': [2168, 4383], 'it': [2169, 3222, 3904, 4006, 4475], '23.3': [2173], 'kb': [2174, 2797], '(31Corchero': [2179], 'Pimprale': [2181], 'Kimura': [2183, 2843, 3374, 3632], 'Gonzalez': [2185, 2851, 2937, 3308, 3376, 3577, 3670, 3725, 3770], 'F.J.': [2186, 2852, 2938, 3309, 3377, 3578, 3671, 3726, 3771, 4549], '11:': [2189], '1-6Google': [2190], 'Dozens': [2192], 'clinical': [2195], 'types': [2203, 2384, 3651], 'reported.CYP1A2CYP1A2': [2211], 'metabolizes': [2212, 2333], 'some': [2213], 'plus': [2215], 'environmental': [2217, 3794, 4498], 'amines:': [2219], 'N-heterocyclic': [2220, 2340], 'charcoal-grilled': [2224], 'food': [2225, 3609], '2-amino-3-methylimidazo[4,5f]quinoline': [2228], '(IQ)': [2229], '2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine': [2231], '(PhIP))': [2232], 'arylamines': [2234, 3971], '2-acetylaminofluorene': [2237], '4-aminobiphenyl': [2239], '(ABP).': [2240], 'Substantial': [2241], 'constitutive': [2242, 2363, 2423, 2463, 2918, 3043], 'occurs': [2245, 2403, 3426], 'liver.': [2248], 'nasal': [2259], 'epithelium,': [2260], 'brain.': [2262], 'Although': [2263], 'there': [2264, 2286, 4321], '>60-fold': [2266], 'hepatic': [2269, 3226, 4045], 'unequivocally': [2292], 'account': [2294], 'striking': [2297], 'interindividual': [2298, 2427], 'expression.': [2303, 2425], 'At': [2304], '14': [2306], 'described': [2317, 4056], 'date': [2319], 'three': [2321, 2616, 3152], 'showing': [2322, 2329], 'decreases': [2323], 'increases': [2330, 3924], 'inducibility.2CYP1B1CYP1B1': [2332], 'well': [2337, 4238], 'amines,': [2341], 'azo': [2344], 'dyes,': [2345], 'several': [2347, 2586, 3075, 3650], 'carcinogens': [2349], 'Unlike': [2357], 'substantial': [2362], 'levels.': [2364], 'vascular': [2370], 'cells,': [2372, 3221, 3875], 'breast,': [2373], 'prostate,': [2374], 'uterus,': [2375], 'lining': [2377], 'head': [2380], 'neck,': [2382], 'tumors,': [2386], 'adrenal': [2387, 2406], 'cortex,': [2388], 'tissues.': [2392], 'That': [2393], 'highest': [2395], 'trimester': [2402], 'cortex': [2407], '(32Rane': [2408], 'Sjöqvist': [2410], 'F.': [2411], 'Orrenius': [2412], '1971;': [2417], '3:': [2418], '305Google': [2419], 'presumably': [2421], 'reflects': [2422], 'CYP1A1)': [2432], 'protein': [2433], '(33Kim': [2441], 'J.H.': [2442], 'Sherman': [2443], 'Curriero': [2445], 'F.C.': [2446], 'Strickland': [2449], 'P.T.': [2450], 'Sutter': [2451], 'Appl.': [2454, 2572, 2940, 3596], '2004;': [2456, 3449, 3962], 'press)Google': [2458], 'although': [2460, 2494], 'what': [2461, 2465], 'inducible': [2467, 2920], 'difficult': [2470], 'distinguish': [2472], 'among': [2473], 'non-smokers,': [2475], 'ex-smokers.': [2477], 'To': [2478, 2725], 'date,': [2479, 2726], '22': [2482], 'none': [2495], 'yet': [2497, 3505], 'via': [2500], 'cDNA': [2501, 4564], 'assays': [2503], 'cause': [2505, 4205], 'decreased': [2506], 'activity.2': [2508], 'inborn-error-of-metabolism': [2517], '(primary': [2518], 'congenital': [2519], 'glaucoma),': [2520], 'suggesting': [2521], 'development': [2523, 2832, 4620], 'anterior': [2526], 'chamber': [2527], 'eye': [2530], 'during': [2531, 4497], 'embryogenesis': [2532], 'require': [2534], 'metabolism': [2535, 3472, 4018, 4022, 4129, 4336], 'endogenous': [2539, 2650], 'substrate': [2540], '(34Nebert': [2543], 'Russell': [2545], 'Lancet.': [2547], '360:': [2549], '1155-1162Google': [2550], 'appears': [2553, 3039, 4476], 'immunotoxicity': [2560, 3425], '(35Galvan': [2561], 'Jaskula-Sztul': [2563], 'R.': [2564], 'MacWilliams': [2565, 3749], 'P.S.': [2566, 3750], 'Czuprynski': [2567, 3753], 'C.J.': [2568, 3754], 'Jefcoate': [2569, 3306, 3723, 3751], '2003;': [2574, 2667, 3541, 3673, 3757, 3992, 4183, 4470, 4553, 4605], '193:': [2575], '84-96Google': [2576], 'Scholar).AHRThe': [2577], 'ligand-activated': [2581], 'transcription': [2582], 'factor': [2583, 4038], 'controls': [2585], '(5Hankinson': [2589, 3155], '3C.': [2608], 'Bradfield,': [2610], 'mcardle.oncology.wisc.edu/bradfield/default.html.': [2611], 'up-regulation': [2613], 'Ligands': [2637], 'include': [2641], 'polyhalogenated': [2644], 'hydrocarbons,': [2646], 'indoles': [2647], 'tryptophan-derived': [2649], 'ligands,': [2651], 'benzoflavones': [2653], 'cruciferous': [2657], 'plants': [2658], '(37Denison': [2659], 'M.S.': [2660], 'Nagy': [2661], 'S.R.': [2662], '43:': [2668], '309-334Google': [2669], 'exists': [2674], 'vertebrates': [2677], 'Caenorhabditis': [2681], 'elegans': [2682], '(11Hahn': [2683], 'participates': [2694], 'cycle': [2697], 'control': [2698], 'apoptosis': [2700], 'type-': [2704, 4233], 'tissue-specific': [2706, 4235], 'nine': [2729], '38Daly': [2753], 'A.K.': [2754, 2768], 'Fairbrother': [2755], 'K.S.': [2756], 'Smart': [2757], 'Lett.': [2760], '102–103:': [2762], '143-147Google': [2763], '39Smart': [2765], 'Daly': [2767], '10:': [2771], '11-24Google': [2772], '4D.': [2774], 'B.': [2779, 3767], 'data.': [2782], 'staggering': [2785], '2,213': [2786], 'spanning': [2795], '∼16': [2796], '13': [2799], '(40Thomas': [2802], 'R.S.': [2803, 2863, 2865, 3245], 'Penn': [2804], 'S.G.': [2805], 'Holden': [2806], 'Bradfield': [2808, 2874], 'C.A.': [2809, 2875], 'Rank': [2810], '12:': [2814], '151-163Google': [2815], 'reported.The': [2819], 'Ahr(–/–)': [2820, 2915, 3005], 'knockout': [2821, 3321], 'lowered': [2824], 'viability': [2825], 'fertility': [2827], 'defects': [2829], 'liver': [2831, 3047, 3077, 3517], '(41Fernandez-Salguero': [2833], 'Pineau': [2835, 3296, 3370, 3713], 'Hilbert': [2837, 2931], 'D.M.': [2838, 2932], 'McPhail': [2839], 'Lee': [2841], 'S.S.T.': [2842], 'Rudikoff': [2847, 2933], 'Ward': [2849, 2935, 3304, 3567, 3666, 3721], 'J.M.': [2850, 2936, 3305, 3568, 3667, 3722], 'Science.': [2853], '268:': [2855], '722-726Google': [2856], '42Lahvis': [2858], 'G.P.': [2859], 'Lindell': [2860], 'S.L.': [2861], 'Thomas': [2862], 'McCuskey': [2864], 'Murphy': [2866], 'Bentz': [2870], 'Southard': [2872], 'Natl.': [2877, 2904, 2967, 3278, 3311, 3356, 3538, 3728, 3989, 4599], 'Acad.': [2878, 2905, 2968, 3279, 3312, 3357, 3729, 4600], 'Sci.': [2879, 2906, 2969, 2999, 3280, 3313, 3358, 3730, 3756, 4601], 'U.': [2880, 2907, 2970, 3281, 3301, 3314, 3359, 3718, 3731, 4602], '97:': [2884, 2911, 2974], '10442-10447Google': [2885], '43Shimizu': [2887], 'Nakatsuru': [2889, 2952], 'Ichinose': [2891, 2954], 'Takahashi': [2893, 2956, 4584], 'Kume': [2895, 2958], 'Mimura': [2897, 2960], 'Fujii-Kuriyama': [2899, 2962, 2994, 3030, 4594], 'Ishikawa': [2901, 2964], '779-782Google': [2912, 2975], 'lacks': [2917], 'TCDD-induced': [2927], '(44Fernandez-Salguero': [2929], 'P.M.': [2930], '140:': [2943], '173-179Google': [2944], 'topical': [2946, 3510], 'BaP-induced': [2947, 3061], 'tumors': [2949, 3763], '(43Shimizu': [2950], 'benzene-induced': [2978], 'hemotoxicity': [2979], '(45Yoon': [2980], 'B.I.': [2981], 'Hirabayashi': [2982], 'Kawasaki': [2984], 'Kodama': [2986], 'Kaneko': [2988], 'Kanno': [2990], 'Kim': [2992], 'D.Y.': [2993], 'Inoue': [2996, 3012], '70:': [3001], '150-156Google': [3002], 'generated': [3007], '(46Shimada': [3010], 'Suzuki': [3014], 'Kawai': [3016], 'Azuma': [3018], 'Nakajima': [3020, 4582], 'Shindo': [3022], 'Kurose': [3024], 'Sugie': [3026], 'Yamagishi': [3028], 'Hashimoto': [3032], '23:': [3036], '1199-1207Google': [3037], 'lung.Paradoxical': [3050], 'Effects': [3051], 'CYP1A2Historically,': [3055], 'demonstrated': [3064], 'Hepa-1c1c7': [3067], 'hepatoma': [3068, 3220, 3806], 'line.': [3070, 4644], 'Hepa-1': [3072, 3124, 3874], 'retain': [3074], 'differentiated': [3076], 'functions,': [3078], 'albumin': [3080], 'synthesis': [3081], 'commonly': [3082], 'lost': [3083], 'BaP-treated': [3123], 'grew': [3126], 'rarely': [3128], 'variants;': [3131], 'colonies': [3133], 'complement': [3137], '“resistance”': [3139], 'colonies,': [3143], 'complementation': [3153], 'groups': [3154], 'ultimately': [3167], 'defined': [3168], 'encoding': [3172], 'Cyp1a1,': [3173], 'Ahr,': [3174], 'dimerization': [3177], 'partner': [3178], 'AHRnuclear': [3182], 'translocator,': [3183], 'Arnt.': [3184], 'Thus,': [3185], 'activates': [3187], 'become': [3190], 'toxic,': [3191], 'ARNT': [3196], 'necessary': [3198], 'Cyp1a1-inducible': [3200], 'expression;': [3201], 'experiments': [3203, 3216], 'primary': [3209, 3815, 3828], 'determinant': [3210, 3816, 3829], 'toxicity.': [3213, 3897, 3926, 4002, 4034], 'Because': [3214], 'conducted': [3218], 'presumed': [3224], 'BaP-mediated': [3234, 3818], 'animal.Cyp1a1(–/–)': [3239], '(47Dalton': [3240], 'Matlib': [3244], 'Childs': [3246], '267:': [3259], '184-189Google': [3260], 'Cyp1a2(–/–)': [3262, 3329, 3480, 3506], '(48Liang': [3263, 3341], 'H.C.L.': [3264, 3342], 'Duffy': [3269, 3347], 'J.J.': [3270, 3348], 'Potter': [3271, 3349], 'S.S.': [3272, 3350], '93:': [3285, 3363], '1671-1676Google': [3286, 3364], 'Cyp1b1(–/–)': [3289, 3680, 3698], '(49Buters': [3290, 3707], 'J.T.': [3291, 3367, 3708, 3765], 'Sakai': [3292, 3709], 'Richter': [3294, 3711], 'Alexander': [3298, 3715], 'D.L.': [3299, 3716], 'Savas': [3300, 3717], 'Doehmer': [3302, 3719], '1999;': [3317, 3580, 3734], '96:': [3318, 3735], '1977-1982Google': [3319, 3736], 'viable': [3324], 'able': [3326], 'reproduce.': [3328], 'exhibit': [3331], 'predominantly': [3338], '50Buters': [3366], 'B.K.': [3369], '6:': [3380], '291-296Google': [3381], 'Cyp1a1(–/–)': [3384, 3394, 3464], 'given': [3387], '(125': [3390], 'mg/kg/day),': 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