Publication Information

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902, 928, 936, 941, 983, 1246, 1351, 1499, 1503, 1527, 1713, 1876, 1986, 2003, 2012, 2028, 2035, 2044, 2082, 2098, 2100, 2112, 2136, 2287, 2477, 2502, 2523, 2549, 2594, 2635, 2641, 2643, 2683, 2739, 2757, 2776, 2839, 2899, 3193, 3254, 3262, 3304, 3319, 3324, 3399, 3443, 3459, 3512, 3547, 3568, 3579, 3632, 3655, 3661, 3668, 3739, 3786, 3795, 3799, 3820, 3869, 3890, 3916, 3926, 3958, 3964, 3997, 4008, 4030, 4068, 4090, 4193, 4275, 4289, 4315, 4325, 4336, 4355, 4373], 'Alzheimer': [3, 254, 507, 515, 592], 'disease': [4, 255, 508], '(AD)': [5, 256, 509], 'and': [6, 15, 45, 61, 72, 89, 111, 123, 143, 161, 212, 235, 248, 257, 266, 296, 312, 323, 340, 362, 374, 394, 412, 463, 486, 499, 520, 597, 703, 713, 803, 808, 907, 974, 1240, 1357, 1375, 1387, 1465, 1501, 1686, 1740, 1777, 1874, 2016, 2038, 2046, 2119, 2143, 2151, 2190, 2244, 2250, 2253, 2291, 2316, 2464, 2475, 2487, 2495, 2504, 2554, 2572, 2588, 2603, 2621, 2699, 2718, 2729, 2746, 2763, 2796, 2816, 2844, 2878, 2895, 2993, 3031, 3034, 3078, 3086, 3110, 3168, 3188, 3244, 3252, 3290, 3327, 3404, 3409, 3533, 3594, 3620, 3647, 3658, 3687, 3700, 3775, 3857, 3907, 3940, 4013, 4021, 4112, 4149, 4168, 4210, 4222, 4303, 4309, 4363], 'vascular': [7, 62, 258, 313], 'dementia': [8, 259], 'is': [9, 30, 48, 195, 260, 281, 299, 446, 664, 689, 797, 884, 953, 960, 977, 1340, 1670, 1732, 1869, 1971, 2114, 3180, 3751, 4096, 4110], 'greatly': [10, 261], 'increased': [11, 241, 262, 492, 1520, 1886, 2042, 3300, 3348, 3455, 3464], 'following': [12, 245, 263, 496, 2218, 2515, 2541, 3003, 3157, 3562], 'cerebral': [13, 246, 264, 497, 1806], 'ischemia': [14, 265, 1767, 1888, 1978], 'stroke': [16, 249, 267, 500], 'in': [17, 22, 59, 103, 105, 205, 209, 228, 268, 273, 310, 354, 356, 456, 460, 479, 670, 900, 964, 1236, 1511, 1533, 1744, 1781, 1871, 2128, 2164, 2236, 2258, 2327, 3015, 3067, 3235, 3269, 3295, 3311, 3341, 3396, 3418, 3423, 3436, 3450, 3518, 3524, 3559, 3634, 3745, 3757, 3770, 3877, 3883, 3897, 3901, 3904, 4027, 4074, 4113, 4166, 4198, 4329, 4345, 4353], 'which': [18, 29, 269, 280, 910, 2007, 3178, 3473], 'hypoxic': [19, 70, 190, 270, 321, 441, 2230, 2607, 3283, 3334, 3389, 3448, 3563, 3628, 3760, 3790], 'conditions': [20, 271, 1694, 1992, 3284], 'occur': [21, 272], 'affected': [23, 274, 3332, 4026], 'brain': [24, 275, 1513, 1776, 1783], 'areas.': [25, 276], 'β-Amyloid': [26, 277], 'peptide': [27, 278], '(Aβ),': [28, 279], 'derived': [31, 282, 682], 'from': [32, 42, 283, 293, 683, 967, 1524, 1769, 2299, 2448, 2459, 2493, 2536, 2677, 2701, 2784, 2971, 3145, 3162, 3172, 3463, 3682, 3715, 4227], 'the': [33, 87, 90, 97, 106, 118, 136, 152, 169, 179, 210, 213, 230, 284, 338, 341, 348, 357, 369, 387, 403, 420, 430, 461, 464, 481, 671, 694, 706, 717, 725, 737, 939, 961, 978, 1372, 1382, 1775, 1984, 2001, 2004, 2013, 2047, 2083, 2124, 2134, 2219, 2312, 2321, 2516, 2542, 2547, 2687, 2753, 2777, 2819, 2831, 2840, 2851, 2855, 2870, 2879, 3002, 3010, 3016, 3068, 3158, 3183, 3249, 3301, 3321, 3419, 3429, 3566, 3659, 3746, 3771, 3796, 3800, 3811, 3821, 3866, 3891, 3913, 3924, 3933, 3981, 3998, 4028, 4050, 4053, 4075, 4087, 4091, 4099, 4129, 4141, 4150, 4186, 4194, 4199, 4211, 4273], 'β-amyloid': [34, 285, 528, 605, 680, 684], 'precursor': [35, 286, 529, 606, 685, 698], 'protein': [36, 162, 207, 287, 413, 458, 686, 699, 1497, 3302, 3313, 3350, 3549, 3633, 4331], '(APP)': [37, 288], 'by': [38, 95, 198, 289, 346, 449, 693, 705, 734, 1887, 2030, 2104, 2597, 2618, 2780, 3107, 3182, 3256, 3307, 3333, 3426, 3445, 3502, 3581, 3644, 3779, 4005], 'sequential': [39, 290], 'proteolytic': [40, 291], 'cleavages': [41, 292], 'β-secretase': [43, 294, 695, 2531], '(BACE1)': [44, 295], 'presenilin-1': [46, 297], '(PS1)/γ-secretase,': [47, 298], 'widely': [49, 300, 885, 2121], 'believed': [50, 301, 886], 'to': [51, 77, 132, 151, 176, 302, 328, 383, 402, 427, 715, 740, 1535, 1677, 1702, 1704, 1736, 1747, 1774, 1879, 1995, 2041, 2140, 2484, 2591, 2672, 2686, 2737, 2771, 2812, 2897, 3000, 3392, 3506, 3698, 3759, 3816, 4098, 4120, 4172, 4287], 'trigger': [52, 303], 'a': [53, 65, 237, 304, 316, 488, 518, 595, 801, 894, 954, 1671, 1711, 1741, 2009, 2018, 2088, 2115, 2237, 2281, 2534, 2773, 2983, 3035, 3308, 3393, 3415, 3433, 3740, 3752, 3765, 3805, 3849, 3898, 3952, 3985, 4061, 4069, 4080, 4323, 4342, 4368], 'cascade': [54, 305, 895], 'pathological': [56, 307], 'events': [57, 308, 1715], 'culminating': [58, 309], 'AD': [60, 244, 311, 495, 912, 950, 1512, 1536, 1810], 'dementia.': [63, 314], 'However,': [64, 315, 1349], 'direct': [66, 317], 'molecular': [67, 238, 318, 489, 1988], 'link': [68, 319], 'between': [69, 320, 1990, 3935], 'insults': [71, 322], 'APP': [73, 107, 134, 234, 324, 358, 385, 485, 535, 612, 688, 730, 942, 984, 1867, 1877, 2045, 2113, 2313, 2488, 3329, 3421, 3437], 'processing': [74, 232, 325, 483], 'has': [75, 114, 326, 365, 1362, 1682], 'yet': [76, 327, 1994], 'be': [78, 329, 732, 1885, 1996, 3782], 'established.': [79, 330, 1997], 'Here,': [80, 331], 'we': [81, 201, 332, 452, 2132, 3272, 3412, 3479, 3762, 3840, 3943, 4291, 4321], 'demonstrate': [82, 222, 333, 473], 'that': [83, 189, 334, 440, 887, 1338, 1519, 1675, 1805, 1973, 2026, 2109, 2470, 3539, 3749, 3852, 4052, 4367], 'acute': [84, 335, 2137, 3263], 'hypoxia': [85, 336, 1980, 2032, 2138, 2587, 2886, 2976, 3264, 3298, 3475, 3486, 3522, 3540, 3569, 3576, 3590, 3881, 3908, 3969, 4157, 4232], 'increases': [86, 104, 158, 337, 355, 409, 1809, 2033, 3558, 3577], 'expression': [88, 194, 339, 445, 1393, 1522, 1868, 2034, 2103, 4285], 'enzymatic': [91, 342], 'activity': [92, 343, 959, 2532, 3344, 3868, 3903, 3915, 4163], 'BACE1': [94, 100, 153, 159, 186, 193, 206, 345, 351, 404, 410, 437, 444, 457, 973, 976, 1237, 1339, 1356, 1383, 1392, 1500, 1521, 2085, 2101, 2110, 2146, 2550, 2637, 2713, 2732, 2778, 3007, 3018, 3022, 3076, 3096, 3255, 3343, 3460, 3477, 3514, 3548, 3560, 3571, 3580, 3649, 3663, 3693, 3747, 3772, 3787, 3802, 3822, 3871, 3999, 4014, 4032, 4055, 4077, 4093, 4135, 4200, 4212, 4247, 4253, 4284, 4330, 4346], 'up-regulating': [96, 347, 3582], 'level': [98, 119, 170, 349, 370, 421, 2634, 3303, 3458, 3660, 4332], 'mRNA,': [101, 352], 'resulting': [102, 353, 899, 1523], 'C-terminal': [108, 359, 539, 616], 'fragment-β': [109, 360], '(βCTF)': [110, 361], 'Aβ.': [112, 363], 'Hypoxia': [113, 364, 3247], 'no': [115, 366, 2096], 'effect': [116, 181, 367, 432, 3567], 'on': [117, 185, 368, 436, 2145, 3265, 3570, 3810, 4086, 4283], 'PS1,': [121, 372], 'APP,': [122, 373, 527, 604], 'tumor': [124, 375, 574, 651], 'necrosis': [125, 376, 575, 652], 'factor-α-converting': [126, 377, 576, 653], 'enzyme': [127, 130, 378, 381, 810], '(TACE,': [128, 379], 'an': [129, 223, 380, 474, 1242, 1341, 1770, 2680, 3025, 3439, 3640, 3949, 4326], 'known': [131, 382], 'cleave': [133, 384], 'at': [135, 386, 2569, 3190, 3472, 3727, 3814, 3980, 4333], 'α-secretase': [137, 388, 735, 796], 'cleavage': [138, 389, 943, 1875, 2111, 2838, 3441], 'site).': [139, 390], 'Sequence': [140, 391, 2080], 'analysis,': [141, 392], 'mutagenesis,': [142, 393], 'gel': [144, 395, 3945, 4190], 'shift': [145, 396, 544, 621, 3946, 4191], 'studies': [146, 397], 'revealed': [147, 398, 2087, 3804, 3951], 'binding': [148, 399, 2021, 2091, 2822, 3013, 3768, 3778, 3808, 3855, 3894, 3938, 4007, 4057, 4072, 4083, 4108, 4196, 4205, 4214], 'HIF-1': [150, 401, 1681, 1707, 2020, 2029, 2090, 2105, 2144, 2821, 3008, 3012, 3023, 3036, 3077, 3080, 3097, 3750, 3767, 3780, 3807, 3854, 3893, 3928, 3937, 3941, 3986, 4000, 4010, 4015, 4033, 4056, 4065, 4071, 4082, 4107, 4195, 4204, 4213, 4242, 4248, 4254], 'promoter.': [154, 405, 4078, 4094, 4201], 'Overexpression': [155, 406], 'HIF-1α': [157, 167, 183, 216, 408, 418, 434, 467, 1685, 1688, 1700, 1731, 1745, 2204, 3115, 3163, 3173, 3312, 3742, 4279, 4316, 4319, 4337], 'mRNA': [160, 411, 2037, 2102, 2733, 3561, 3694, 4347], 'level,': [163, 414, 4348], 'whereas': [164, 415, 3527], 'down-regulation': [165, 416], 'reduced': [168, 419], 'BACE1.': [172, 423], 'Hypoxic': [173, 424, 2152], 'treatment': [174, 425, 3390], 'fails': [175, 426], 'further': [177, 428, 2024, 3931], 'potentiate': [178, 429, 3912], 'stimulatory': [180, 431], 'overexpression': [184, 435, 4280, 4320], 'expression,': [187, 438, 3478], 'suggesting': [188, 439, 1518, 3538], 'induction': [191, 442], 'primarily': [196, 447], 'mediated': [197, 448], 'HIF-1α.': [199, 450], 'Finally,': [200, 451], 'observed': [202, 453, 3414, 4322, 4341], 'significant': [203, 454, 3339, 3899], 'reduction': [204, 455, 3900], 'levels': [208, 459, 1498, 1526, 1689, 2734, 2738, 3318, 3351, 3398, 3650, 3695, 4354], 'hippocampus': [211, 462, 3167], 'cortex': [214, 465, 3169], 'conditional': [217, 468, 3174], 'knock-out': [218, 469, 3175], 'mice.': [219, 470], 'Our': [220, 471], 'results': [221, 472, 1768, 3922], 'important': [224, 475, 503, 3836], 'role': [225, 476], 'for': [226, 240, 477, 491, 949, 981, 1345, 1734, 2117, 2247, 2530, 2564, 2574, 2583, 2599, 2712, 2723, 2809, 2835, 2887, 2977, 3237, 3241, 3287, 3491, 3530, 3591, 3601, 3617, 3623, 3689, 3764, 3784, 3837, 3970, 4158, 4233], 'hypoxia/HIF-1α': [227, 478], 'modulating': [229, 480], 'amyloidogenic': [231, 482, 1880], 'provide': [236, 487, 946], 'mechanism': [239, 490], 'ischemic': [247, 498], 'injuries.': [250, 501], 'An': [502], 'pathologic': [504], 'feature': [505], '4The': [510, 587], 'abbreviations': [511, 588], 'used': [512, 589, 2483, 2671, 2711, 2722, 2791, 3118, 3240], 'are:': [513, 590], 'AD,': [514, 591, 1987], 'disease;': [516, 593], 'ADAM10,': [517, 594], 'disintegrin': [519, 596, 802], 'metalloprotease': [521, 598, 804], 'domain': [522, 599, 739, 805], '10;': [523, 600], 'APH-1,': [524, 601, 712], 'anterior': [525, 602], 'pharynx-defective-1;': [526, 603], 'protein;': [530, 607], 'Aβ,': [531, 608], 'β-amyloids;': [532, 609], 'BACE,': [533, 610], 'beta-site': [534, 611], 'cleaving': [536, 613, 700], 'enzyme;': [537, 577, 614, 654], 'CTF,': [538, 615], 'fragment;': [540, 551, 617, 628], 'EMSA,': [541, 618], 'electrophoretic': [542, 619], 'mobility': [543, 620], 'assay;': [545, 581, 622, 658], 'HIF-1,': [546, 623], 'hypoxia-inducible': [547, 624], 'factor-1;': [548, 625], 'NTF,': [549, 626], 'N-terminal': [550, 627], 'N2a-APP,': [552, 629], 'N2a': [553, 630, 2155, 2786, 2876, 3089, 3276, 3451], 'cells': [554, 631, 2156, 2199, 2233, 2255, 2497, 2527, 2557, 2580, 2645, 2787, 2880, 2973, 3151, 3277, 3425, 3452, 3519, 3535, 3586, 3611, 3670, 3686, 3878, 3885, 3906, 3966, 4151, 4229, 4294], 'stably': [555, 632, 2157, 3278], 'expressing': [556, 633, 2158, 3279], 'human': [557, 634, 2159, 2478, 3280], 'APP695;': [558, 635], 'PEN-2,': [559, 636], 'presenilin': [560, 637], 'enhancer-2;': [561, 638], 'PS,': [562, 639], 'presenilin;': [563, 640], 'RT-PCR,': [564, 641], 'real-time': [565, 642, 3553], 'polymerase': [566, 643], 'chain': [567, 644], 'reaction;': [568, 645], 'siRNA,': [569, 646], 'small': [570, 647, 677, 1352, 1369], 'interfering': [571, 648], 'RNA;': [572, 649], 'TACE,': [573, 650, 3320], 'ELISA,': [578, 655], 'enzyme-linked': [579, 656], 'immunosorbent': [580, 657], 'RIPA,': [582, 659], 'radioimmune': [583, 660], 'precipitation': [584, 661], 'assay': [585, 662, 2546], 'buffer.': [586, 663], 'formation': [665, 901], 'extracellular': [667], 'senile': [668, 903], 'plaques': [669], 'brain,': [672, 1873], 'whose': [673, 958], 'major': [674, 979, 1672], 'components': [675], 'are': [676, 812, 1238, 1690, 2095], 'peptides': [678, 1882], 'called': [679], '(Aβ)': [681], '(APP).': [687], 'sequentially': [690], 'cleaved': [691, 733], 'first': [692, 2674, 3613], '(β-site': [696], 'amyloid': [697], 'enzyme,': [701], 'BACE)': [702], 'then': [704, 2589, 3595, 3621], 'γ-secretase': [707], 'complex': [708, 3954, 3978, 3989, 4002, 4062], '(including': [709], 'presenilin,': [710], 'nicastrin,': [711], 'PEN-2)': [714], 'generate': [716, 741, 3001], 'heterogeneous': [718], 'Aβ': [719, 738, 888, 932, 965, 1247, 1347, 1516, 1881, 2130, 2479, 2486, 3270, 3401], 'species,': [720], 'mostly': [721], 'Aβ40': [722, 2503, 3403], 'but': [723, 800, 1695, 3338, 4023], 'also': [724, 4340], 'more': [726], 'deleterious': [727], 'Aβ42.': [728], 'Alternatively,': [729], 'can': [731, 4059], 'within': [736], 'non-amyloidogenic': [742], 'soluble': [743], 'APPα': [744], '(sAPPα)': [745], '(1Vetrivel': [746], 'K.S.': [747], 'Zhang': [748, 1282, 2052, 2054, 2058, 2066, 2909, 2911, 2915, 2923, 2939, 2945, 2947, 2955, 3361, 3363, 3367, 3375], 'Y.W.': [749, 2053, 2910, 2940, 3362], 'Xu': [750, 770, 2068, 2426, 2925, 2953, 3377], 'H.': [751, 771, 781, 1049, 1114, 1218, 1249, 1255, 1281, 1307, 1402, 2069, 2364, 2423, 2427, 2926, 2954, 3124, 3378], 'Thinakaran': [752, 2369], 'G.': [753, 1030, 1116, 1173, 1440, 1557, 2370, 2395], 'Mol.': [754, 784, 1174, 1409, 2957], 'Neurodegener.': [755, 785], '2006;': [756, 786, 1457, 1488, 1574, 1600, 2072, 2929, 2960, 3132, 3381], '1:': [757, 787], '4Crossref': [758], 'PubMed': [759, 777, 789, 847, 878, 921, 1037, 1076, 1139, 1180, 1204, 1229, 1267, 1295, 1325, 1415, 1460, 1491, 1577, 1603, 1637, 1662, 1726, 1761, 1797, 1832, 1849, 1861, 1904, 1935, 1964, 2075, 2358, 2389, 2413, 2439, 2932, 2963, 3058, 3135, 3226, 3384], 'Scopus': [760, 790, 848, 879, 922, 1038, 1077, 1140, 1181, 1205, 1230, 1268, 1296, 1326, 1416, 1461, 1492, 1578, 1604, 1638, 1663, 1727, 1762, 1798, 1850, 1862, 1905, 1936, 1965, 2076, 2359, 2390, 2414, 2440, 2933, 2964, 3136, 3227, 3385], '(121)': [761], 'Google': [762, 778, 792, 850, 881, 924, 1040, 1079, 1142, 1183, 1207, 1232, 1270, 1298, 1328, 1418, 1463, 1494, 1580, 1606, 1640, 1665, 1729, 1764, 1800, 1833, 1852, 1864, 1907, 1938, 1967, 2078, 2361, 2392, 2416, 2442, 2935, 2966, 3059, 3138, 3229, 3387], 'Scholar,': [763, 779, 851, 1041, 1080, 1143, 1184, 1208, 1271, 1299, 1581, 1607, 1641, 1834, 1853, 1908, 1939, 2362, 2393, 2417, 2936], '2Greenfield': [764], 'J.P.': [765, 1084, 1838], 'Gross': [766], 'R.S.': [767, 829, 1755, 3216], 'Gouras': [768], 'G.K.': [769], 'Front': [772], 'Biosci.': [773], '2000;': [774, 1226, 1858, 1901], '5:': [775], 'D72-D83Crossref': [776], '3Zheng': [780], 'Koo': [782], 'E.H.': [783], '5Crossref': [788], '(285)': [791], 'Scholar).': [793, 882, 925, 1233, 1329, 1495, 1730, 1765, 1801, 1865, 1968, 2079, 2443, 2967, 3060, 3139, 3230], 'exact': [795], 'not': [798, 1358, 3331, 3910, 4025], 'known,': [799], '10': [806, 2567, 3494, 3604, 4304], '(ADAM10)': [807], 'TNF-α-converting': [809], '(TACE)': [811], 'two': [813, 970, 1683], 'likely': [814, 1972], 'candidates': [815], '(4Buxbaum': [816], 'J.D.': [817, 2331], 'Liu': [818, 1280, 1644, 2056, 2913, 2943, 3365], 'K.N.': [819], 'Luo': [820, 1005], 'Y.': [821, 1006, 1251, 1273, 1631, 1821, 1914, 1947, 3122, 3126], 'Slack': [822], 'J.L.': [823], 'Stocking': [824], 'K.L.': [825], 'Peschon': [826], 'J.J.': [827], 'Johnson': [828, 1754, 3215], 'Castner': [830], 'B.J.': [831], 'Cerretti': [832], 'D.P.': [833], 'Black': [834], 'R.A.': [835], 'J.': [836, 914, 1010, 1014, 1028, 1100, 1108, 1118, 1130, 1193, 1283, 1442, 1486, 1559, 1598, 1753, 1757, 1788, 1890, 1928, 1959, 2065, 2071, 2428, 2922, 2928, 2952, 3052, 3129, 3198, 3221, 3374, 3380], 'Biol.': [837, 1194, 1411, 1721, 2429, 2959], 'Chem.': [838, 1195, 2430], '1998;': [839, 1758, 2410], '273:': [840], '27765-27767Abstract': [841], 'Full': [842, 844, 1199, 1201, 1320, 1322, 2434, 2436], 'Text': [843, 845, 1200, 1202, 1321, 1323, 2435, 2437], 'PDF': [846, 1203, 1324, 2438], '(834)': [849], '5Lammich': [852], 'S.': [853, 859, 873, 990, 992, 1000, 1008, 1012, 1082, 1126, 1224, 1406, 1426, 1455, 1485, 1543, 1572, 1597, 1651, 1912, 1926, 2061, 2353, 2378, 2384, 2918, 3214, 3370], 'Kojro': [854], 'E.': [855, 1020, 1430, 1547, 1817, 1836, 3043], 'Postina': [856], 'R.': [857, 861, 986, 1004, 1043, 1086, 1090, 1186, 1287, 1313, 1483, 1595, 1613, 1629, 1827, 1922, 2051, 2057, 2368, 2419, 2908, 2914, 2938, 2944, 3128, 3196, 3360, 3366], 'Gilbert': [858], 'Pfeiffer': [860], 'Jasionowski': [862], 'M.': [863, 1032, 1094, 1112, 1210, 1289, 1301, 1311, 1422, 1539, 1615, 1786, 1815, 1823, 1920, 1951], 'Haass': [864], 'C.': [865, 1155, 1171, 1473, 1585, 3204, 3206, 3220], 'Fahrenholz': [866], 'F.': [867, 1026, 1447, 1564], 'Proc.': [868, 1219, 1450, 1567, 2348, 2379], 'Natl.': [869, 1220, 1451, 1568, 2349, 2380], 'Acad.': [870, 1221, 1452, 1569, 2350, 2381], 'Sci.': [871, 1222, 1453, 1570, 2351, 2382, 3054], 'U.': [872, 1223, 1454, 1475, 1571, 1587, 2352, 2383], 'A.': [874, 1225, 1404, 1456, 1477, 1481, 1573, 1589, 1593, 1957, 2354, 2385], '1999;': [875, 1034, 1073, 1136, 1177], '96:': [876, 1489, 1601], '3922-3927Crossref': [877], '(977)': [880], 'It': [883], 'overproduction': [889], 'directly': [890], 'or': [891, 1979, 1982, 2106, 2206, 2525, 2566, 2884, 3093, 3101, 3239, 3468, 3493, 3498, 3603, 3684, 3848, 4040, 4132, 4155, 4259, 4358], 'indirectly': [892], 'initiates': [893], 'neurodegenerative': [897], 'steps': [898], 'plaques,': [904, 1517], 'neurofibrillary': [905], 'tangles,': [906], 'neuronal': [908, 1779], 'loss,': [909], 'characterize': [911], '(6Hardy': [913], 'Selkoe': [915], 'D.J.': [916], 'Science.': [917, 1033], '2002;': [918], '297:': [919], '353-356Crossref': [920], '(10801)': [923], 'Hence': [926], 'analysis': [927, 2081, 2620, 2748, 3555, 3646, 3794, 3950], 'cellular': [929, 1678, 1974, 3349], 'regulation': [930, 2099], 'affecting': [931], 'generation,': [933, 3271], 'including': [934, 1395], 'identification': [935, 1350], 'factors': [937, 1390, 1506], 'regulating': [938, 1391, 1710], 'level/activity': [940], 'enzymes,': [944], 'should': [945], 'invaluable': [947], 'information': [948], 'therapeutic': [951, 1343], 'intervention.BACE': [952], 'membrane-bound': [955], 'aspartic': [956, 1360], 'protease': [957, 980, 2282], 'rate-limiting': [962], 'step': [963, 2127], 'production': [966], 'APP.': [968], 'Among': [969], 'BACE': [971, 2793, 2797, 2807], 'homologs,': [972], 'BACE2,': [975], 'β-cleavage': [982], '(7Vassar': [985], 'Bennett': [987], 'B.D.': [988], 'Babu-Khan': [989], 'Kahn': [991], 'Mendiaz': [993], 'E.A.': [994, 1303], 'Denis': [995], 'P.': [996, 1002, 1106, 1122, 1432, 1549, 1625, 1717, 2335, 2347, 2376, 2421, 2425, 2942], 'Teplow': [997], 'D.B.': [998, 1063], 'Ross': [999], 'Amarante': [1001], 'Loeloff': [1003], 'Fisher': [1007], 'Fuller': [1009], 'Edenson': [1011], 'Lile': [1013], 'Jarosinski': [1015], 'M.A.': [1016, 1277, 1398], 'Biere': [1017], 'A.L.': [1018, 1896], 'Curran': [1019], 'Burgess': [1021], 'T.': [1022, 1444, 1561, 1621, 1910, 1916, 1918], 'Louis': [1023], 'J.C.': [1024], 'Collins': [1025], 'Treanor': [1027], 'Rogers': [1029], 'Citron': [1031, 1288, 1310, 1614], '286:': [1035], '735-741Crossref': [1036], '(3256)': [1039], '8Yan': [1042], 'Bienkowski': [1044, 1191], 'M.J.': [1045, 1192], 'Shuck': [1046, 1189], 'M.E.': [1047, 1071, 1190, 2337], 'Miao': [1048, 2422], 'Tory': [1050], 'M.C.': [1051], 'Pauley': [1052], 'A.M.': [1053], 'Brashier': [1054], 'J.R.': [1055, 3200], 'Stratman': [1056], 'N.C.': [1057], 'Mathews': [1058], 'W.R.': [1059], 'Buhl': [1060], 'A.E.': [1061], 'Carter': [1062], 'Tomasselli': [1064], 'A.G.': [1065], 'Parodi': [1066], 'L.A.': [1067], 'Heinrikson': [1068], 'R.L.': [1069], 'Gurney': [1070], 'Nature.': [1072, 1135], '402:': [1074, 1137], '533-537Crossref': [1075], '(1328)': [1078], '9Sinha': [1081], 'Anderson': [1083], 'Barbour': [1085], 'Basi': [1087], 'G.S.': [1088], 'Caccavello': [1089], 'Davis': [1091], 'D.': [1092, 1120, 1128, 1147, 1216, 1253, 1279, 1627, 1953, 2366], 'Doan': [1093], 'Dovey': [1095], 'H.F.': [1096], 'Frigon': [1097], 'N.': [1098, 1104, 1214, 1428, 1545, 1924], 'Hong': [1099, 2060, 2917, 3369], 'Jacobson-Croak': [1101], 'K.': [1102, 1471, 1583, 1611, 1719, 2063, 2920, 2950, 3372], 'Jewett': [1103], 'Keim': [1105], 'Knops': [1107], 'Lieberburg': [1109], 'I.': [1110, 1145, 1424, 1541, 1941, 1943, 3212], 'Power': [1111], 'Tan': [1113], 'Tatsuno': [1115], 'Tung': [1117], 'Schenk': [1119], 'Seubert': [1121], 'Suomensaari': [1123], 'S.M.': [1124], 'Wang': [1125, 1250, 2367], 'Walker': [1127, 1948], 'Zhao': [1129], 'McConlogue': [1131], 'L.': [1132, 1436, 1553, 1623, 1894, 1949, 3210], 'John': [1133], 'V.': [1134], '537-540Crossref': [1138], '(1472)': [1141], '10Hussain': [1144], 'Powell': [1146], 'Howlett': [1148], 'D.R.': [1149, 1257, 1438, 1555, 2405], 'Tew': [1150], 'D.G.': [1151], 'Meek': [1152], 'T.D.': [1153], 'Chapman': [1154], 'Gloger': [1156], 'I.S.': [1157], 'Murphy': [1158, 1650], 'K.E.': [1159], 'Southan': [1160], 'C.D.': [1161], 'Ryan': [1162], 'D.M.': [1163], 'Smith': [1164], 'T.S.': [1165], 'Simmons': [1166], 'D.L.': [1167, 1259, 2403], 'Walsh': [1168], 'F.S.': [1169], 'Dingwall': [1170], 'Christie': [1172], 'Cell': [1175, 1410, 2609, 3053], 'Neurosci.': [1176, 1263, 1960, 3222], '14:': [1178, 1293], '419-427Crossref': [1179], '(997)': [1182], '11Yan': [1185], 'Munzner': [1187], 'J.B.': [1188, 2397], '2001;': [1196, 1264, 1932, 2431, 3055], '276:': [1197, 2432], '34019-34027Abstract': [1198], '(147)': [1206], '12Farzan': [1209], 'Schnitzler': [1211], 'C.E.': [1212], 'Vasilieva': [1213], 'Leung': [1215], 'Choe': [1217], '97:': [1227], '9712-9717Crossref': [1228], '(343)': [1231], 'Mice': [1234], 'deficient': [1235], 'viable': [1239], 'show': [1241], 'almost': [1243], 'total': [1244, 3342, 3420, 3678], 'loss': [1245], '(13Cai': [1248], 'McCarthy': [1252], 'Wen': [1254], 'Borchelt': [1256, 2404], 'Price': [1258, 1626, 2402], 'Wong': [1260, 1624], 'P.C.': [1261], 'Nat.': [1262, 1632], '4:': [1265, 2411], '233-234Crossref': [1266], '(942)': [1269], '14Luo': [1272], 'Bolon': [1274], 'B.': [1275, 1479, 1591, 1945, 3208], 'Damore': [1276], 'Fitzpatrick': [1278], 'Yan': [1284, 1612], 'Q.': [1285], 'Vassar': [1286, 1312], 'Neurobiol.': [1290, 1856, 2408], 'Dis.': [1291, 2409], '2003;': [1292, 1634], '81-88Crossref': [1294], '(151)': [1297], '15Ohno': [1300], 'Sametsky': [1302], 'Younkin': [1304, 1308], 'L.H.': [1305], 'Oakley': [1306], 'S.G.': [1309], 'Disterhoft': [1314], 'J.F.': [1315], 'Neuron.': [1316], '2004;': [1317, 1412, 1723, 1961], '41:': [1318], '27-33Abstract': [1319], '(456)': [1327], 'These': [1330, 3921, 4047], 'findings,': [1331], 'together': [1332], 'with': [1333, 2203, 2280, 2560, 2586, 2613, 2679, 2806, 2842, 2867, 2883, 2995, 3024, 3084, 3088, 3092, 3282, 3355, 3485, 3489, 3521, 3589, 3597, 3615, 3639, 3702, 3961, 4063, 4140, 4154, 4220, 4224, 4240, 4295, 4350], 'other': [1334, 1359], 'biochemical': [1335], 'studies,': [1336], 'indicate': [1337, 3923], 'ideal': [1342], 'target': [1344], 'blocking': [1346], 'production.': [1348], 'molecules': [1353, 1370], 'specifically': [1354], 'targeting': [1355], 'proteases': [1361], 'been': [1363, 1508], 'challenging.': [1364], 'In': [1365, 2576, 3606], 'addition,': [1366], 'delivering': [1367], 'inhibitory': [1368], 'across': [1371], 'cell': [1373, 2165, 3635], 'membrane': [1374], 'blood-brain': [1376], 'barrier': [1377], 'poses': [1378], 'another': [1379], 'difficulty.': [1380], 'Recently,': [1381], 'promoter': [1384, 2002, 2086, 3019, 3773, 3838, 3867, 3872, 3902, 3914, 4136], 'was': [1385, 2298, 2447, 2458, 2646, 2658, 2670, 2749, 2769, 2804, 2902, 3065, 3119, 3144, 3148, 3345, 3515, 3671, 3680, 3835, 3874, 4003, 4024, 4164], 'defined,': [1386], 'several': [1388], 'transcription': [1389, 1505, 1673, 3572, 3754, 3788], 'identified,': [1394], 'SP1': [1396, 3062, 4041, 4260], '(16Christensen': [1397], 'Zhou': [1399], 'W.': [1400, 1408, 1617], 'Qing': [1401], 'Lehman': [1403], 'Philipsen': [1405], 'Song': [1407], '24:': [1413], '865-874Crossref': [1414], '(188)': [1417], 'Scholar),': [1419, 1464, 3388], 'PPARγ': [1420], '(17Sastre': [1421, 1538], 'Dewachter': [1423, 1540], 'Rossner': [1425, 1484, 1542, 1596], 'Bogdanovic': [1427, 1544], 'Rosen': [1429, 1546], 'Borghgraef': [1431, 1548], 'Evert': [1433, 1550], 'B.O.': [1434, 1551], 'Dumitrescu-Ozimek': [1435, 1552], 'Thal': [1437, 1554], 'Landreth': [1439, 1556], 'Walter': [1441, 1558], 'Klockgether': [1443, 1560], 'van': [1445, 1562], 'Leuven': [1446, 1563], 'Heneka': [1448, 1565], 'M.T.': [1449, 1566], '103:': [1458, 1575], '443-448Crossref': [1459, 1576], '(346)': [1462, 1579], 'Yin': [1466], 'Yang': [1467, 1618, 1891], '1': [1468, 1668], '(YY1)': [1469], '(18Nowak': [1470], 'Lange-Dohna': [1472, 1584], 'Zeitschel': [1474, 1586], 'Gunther': [1476, 1588], 'Luscher': [1478, 1590], 'Robitzki': [1480, 1592], 'Perez-Polo': [1482, 1594], 'Neurochem.': [1487, 1599], '1696-1707Crossref': [1490, 1602], '(67)': [1493, 1605], 'Interestingly,': [1496], 'some': [1502, 2577, 3607], 'these': [1504, 1991], 'have': [1507, 1993], 'found': [1509], 'altered': [1510, 1525], 'regions': [1514, 4137], 'containing': [1515, 2168, 2241, 2854, 2869, 3009, 3845], 'its': [1528], 'transcriptional': [1529, 1714], 'activators': [1530], 'may': [1531, 1883, 3461], 'contribute': [1532], 'part': [1534], 'pathogenesis': [1537, 1985], '18Nowak': [1582], '19Yang': [1608], 'L.B.': [1609], 'Lindholm': [1610], 'Xia': [1616, 2062, 2064, 2919, 2921, 2949, 2951, 3371, 3373], 'X.L.': [1619], 'Beach': [1620], 'Sue': [1622], 'Li': [1628], 'Shen': [1630], 'Med.': [1633], '9:': [1635], '3-4Crossref': [1636], '(583)': [1639], '20Johnston': [1642], 'J.A.': [1643, 3202], 'W.W.': [1645], 'Todd': [1646], 'S.A.': [1647, 3218], 'Coulson': [1648], 'D.T.': [1649], 'Irvine': [1652], 'G.B.': [1653], 'Passmore': [1654], 'A.P.': [1655], 'Biochem.': [1656, 3131], 'Soc.': [1657], 'Trans.': [1658], '2005;': [1659, 1794, 3223], '33:': [1660], '1096-1100Crossref': [1661], '(60)': [1664], 'Scholar).Hypoxia-inducible': [1666], 'factor': [1667, 1674, 3755], '(HIF-1)': [1669], 'responds': [1676], 'oxygen': [1679, 1738, 1772, 3447], 'reduction.': [1680], 'subunits,': [1684], 'HIF-1β.': [1687], 'low': [1691, 1737, 3446], 'under': [1692, 1698, 2606, 2975, 3509, 3627, 3789, 3880, 3968, 4231], 'physiological': [1693], 'increase': [1696, 3310, 3340, 3395, 3435, 4328, 4344], 'dramatically': [1697], 'hypoxia.': [1699, 2107, 3510], 'binds': [1701], 'HIF-1β': [1703], 'form': [1705, 3851, 4060], 'functional': [1706, 2019, 4070], 'heterodimers,': [1708], 'consequently': [1709], 'series': [1712], '(21Maxwell': [1716], 'Salnikow': [1718], 'Cancer': [1720], 'Ther.': [1722], '3:': [1724], '29-35Crossref': [1725], '(195)': [1728], 'essential': [1733], 'adaptation': [1735], 'levels,': [1739, 3314], 'complete': [1742], 'deficiency': [1743], 'leads': [1746], 'embryonic': [1748], 'lethality': [1749], '(22Ryan': [1750], 'H.E.': [1751], 'Lo': [1752, 2371], 'EMBO': [1756], '17:': [1759], '3005-3015Crossref': [1760], '(1323)': [1763], 'Cerebral': [1766], 'insufficient': [1771], 'supply': [1773], 'causes': [1778], 'damage': [1780], 'vulnerable': [1782], 'areas': [1784], '(23Koistinaho': [1785], 'Koistinaho': [1787], 'Brain': [1789, 1791, 1899], 'Res.': [1790, 1792, 1900], 'Rev.': [1793], '48:': [1795], '240-250Crossref': [1796], '(130)': [1799], 'Accumulating': [1802], 'evidence': [1803], 'indicates': [1804], 'ischemia/stroke': [1807], 'significantly': [1808, 3299, 3516, 3875, 3911], 'risk': [1811], '(24Tatemichi': [1812], 'T.K.': [1813], 'Paik': [1814], 'Bagiella': [1816], 'Desmond': [1818], 'D.W.': [1819], 'Stern': [1820], 'Sano': [1822], 'Hauser': [1824], 'W.A.': [1825], 'Mayeux': [1826], 'Neurology.': [1828, 1845], '1994;': [1829], '44:': [1830], '1885-1891Crossref': [1831], '25Kokmen': [1835], 'Whisnant': [1837], "O'Fallon": [1839], 'W.M.': [1840], 'Chu': [1841], 'C.P.': [1842], 'Beard': [1843], 'C.M.': [1844, 2399], '1996;': [1846], '46:': [1847], '154-159Crossref': [1848], '(382)': [1851], '26Kalaria': [1854], 'R.N.': [1855], 'Aging.': [1857], '21:': [1859], '321-330Crossref': [1860], '(485)': [1863], 'Moreover,': [1866, 3888], 'elevated': [1870], 'post-ischemic': [1872], 'leading': [1878, 2040], 'hence': [1884], '(27Shi': [1889], 'S.H.': [1892], 'Stubley': [1893], 'Day': [1895], 'Simpkins': [1897], 'J.W.': [1898, 3051], '853:': [1902], '1-4Crossref': [1903], '(126)': [1906], '28Nihashi': [1909], 'Inao': [1911], 'Kajita': [1913], 'Kawai': [1915], 'Sugimoto': [1917], 'Niwa': [1919], 'Kabeya': [1921], 'Hata': [1923], 'Hayashi': [1925], 'Yoshida': [1927], 'Acta': [1929], 'Neurochir.': [1930], '(Wien).': [1931], '143:': [1933], '287-295Crossref': [1934], '(105)': [1937], '29Badan': [1940], 'Dinca': [1942], 'Buchhold': [1944], 'Suofu': [1946], 'Gratz': [1950], 'Platt': [1952], 'Kessler': [1954], 'C.H.': [1955], 'Popa-Wagner': [1956], 'Eur.': [1958], '19:': [1962], '2270-2280Crossref': [1963], '(69)': [1966], 'Although': [1969], 'it': [1970], 'stresses': [1975], 'such': [1976], 'as': [1977, 2123, 2293, 2648, 2788, 2904, 3315, 3673, 3706, 3826, 3984, 4104], 'facilitate': [1981], 'worsen': [1983], 'links': [1989], 'We': [1998, 2023, 4339], 'recently': [1999], 'characterized': [2000], 'APH-1a': [2005, 2036], 'gene,': [2006], 'encodes': [2008], 'key': [2010, 2125, 3266], 'component': [2011], 'PS1/γ-secretase': [2014], 'complex,': [2015], 'identified': [2017, 4054, 4085], 'element.': [2022], 'demonstrated': [2025], 'activation': [2027], 'short-term': [2031], 'protein,': [2039, 3942], 'γ-cleavage': [2043, 2118], 'Notch': [2048], 'receptor': [2049], '(30Wang': [2050, 2907, 3359], 'X.': [2055, 2059, 2912, 2916, 2946, 2948, 3364, 3368], 'Z.': [2067, 2924, 2956, 3376], 'Faseb': [2070, 2927, 3379], '20:': [2073, 2930, 3382], '1275-1277Crossref': [2074, 2931, 3383], '(87)': [2077, 2934, 3386], 'mouse': [2084, 2785, 3017, 3114, 3274, 3801, 4076, 4092, 4134], 'putative': [2089, 3079, 3892], 'element,': [2092], 'although': [2093], 'there': [2094], 'reports': [2097], 'Given': [2108], 'prerequisite': [2116], 'thus': [2120], 'viewed': [2122], 'regulatory': [2126], 'inhibiting': [2129], 'production,': [2131], 'investigated': [2133], 'effects': [2135, 3261, 4282], '(up': [2139], '8': [2141, 2251, 3291], 'h)': [2142], 'expression.EXPERIMENTAL': [2147], 'PROCEDURESCell': [2148], 'Culture,': [2149], 'Transfection,': [2150], 'Treatment—Mouse': [2153], 'neuroblastoma': [2154, 3275], 'APP695': [2160, 3281], '(N2a-APP)': [2161], 'were': [2162, 2200, 2223, 2234, 2256, 2289, 2325, 2482, 2498, 2506, 2528, 2558, 2581, 2611, 2624, 2692, 2704, 2735, 2744, 2792, 2828, 2848, 2865, 2881, 2893, 2980, 2991, 3082, 3105, 3170, 3232, 3330, 3487, 3536, 3587, 3612, 3637, 3651, 3696, 4138, 4152, 4170, 4218, 4238, 4312], 'maintained': [2163], 'culture': [2166], 'medium': [2167, 2173, 2179], '50%': [2169, 2177], 'DME': [2170], 'high': [2171], 'glucose': [2172], '(Hyclone,': [2174, 2187], 'Logan,': [2175, 2188], 'CT),': [2176, 2189], 'OptiMEM': [2178], '(Invitrogen,': [2180, 2512, 2663], 'Carlsbad,': [2181, 2513, 2664, 2988], 'CA),': [2182, 2514, 2540], '5%': [2183, 2245], 'fetal': [2184], 'bovine': [2185], 'serum': [2186], '0.2': [2191], 'mg/ml': [2192], 'G418': [2193], '(Omega': [2194], 'Scientific,': [2195], 'Tarzana,': [2196], 'CA).': [2197, 2454, 2665, 2989], 'N2a-APP': [2198, 2232, 2556, 2579, 2972, 3585, 3862, 3965, 4147, 4228, 4293], 'transiently': [2201], 'transfected': [2202, 3149, 3858, 4292], 'cDNA': [2205, 2676], 'pcDNA': [2207], '(as': [2208], 'control)': [2209], 'using': [2210, 2508, 2533, 2626, 2660, 2694, 2706, 2752, 2781, 2982, 3152], 'FuGENE': [2211], '6': [2212], '(Roche': [2213], 'Applied': [2214], 'Science,': [2215], 'Indianapolis,': [2216], 'IN),': [2217], "manufacturer's": [2220, 2517, 2543, 2688, 3159], 'instructions.': [2221], 'Cells': [2222, 3483], 'harvested': [2224], '48': [2225], 'h': [2226, 2585, 2979, 3593, 3972], 'after': [2227, 2638, 3664, 3956], 'transfection.': [2228], 'For': [2229], 'treatment,': [2231, 3564], 'incubated': [2235, 3087, 4223], '37': [2238, 2570], '°C': [2239, 2571], 'chamber': [2240], '1%': [2242, 2269, 2272], 'O2': [2243], 'CO2': [2246], '2,': [2248, 3288, 4301, 4308], '4,': [2249, 3289, 4361], 'h.Immunoblotting': [2252], 'Antibodies—Treated': [2254], 'lysed': [2257, 3234], 'RIPA': [2259, 3236], '(150': [2260], 'mm': [2261, 2265], 'sodium': [2262, 2273, 2276], 'chloride,': [2263], '50': [2264], 'Tris-HCl,': [2266], 'pH': [2267], '7.4,': [2268], 'Triton': [2270], 'X-100,': [2271], 'deoxycholate,': [2274], '0.1%': [2275], 'dodecyl': [2277], 'sulfate,': [2278], 'supplemented': [2279], 'inhibitor': [2283], 'mixture).': [2284], 'Equal': [2285, 3630], 'amounts': [2286, 3631], 'lysates': [2288, 2610, 3636], 'analyzed': [2290, 2705, 3106], 'immunoblotted': [2292], 'indicated.': [2294], 'Mouse': [2295, 2455], 'anti-HIF-1α': [2296], 'antibody': [2297, 2306, 2309, 2318, 2446, 2457, 2615], 'Novus': [2300], 'Biologicals': [2301], '(Littleton,': [2302], 'CO).': [2303], 'Rabbit': [2304, 2444], 'anti-BACE1': [2305, 2614, 3641], 'B690,': [2307, 2616], 'rabbit': [2308, 2317], '369': [2310], 'against': [2311, 2320], 'C': [2314, 3408], 'terminus,': [2315], 'Ab14': [2319], 'PS1': [2322, 3325, 4356], 'N': [2323, 3322], 'terminus': [2324, 3323], 'developed': [2326], 'our': [2328, 3356], 'laboratory': [2329], '(31Buxbaum': [2330], 'Gandy': [2332, 2377], 'S.E.': [2333, 3714, 4180], 'Cicchetti': [2334], 'Ehrlich': [2336], 'Czernik': [2338], 'A.J.': [2339, 2345], 'Fracasso': [2340], 'R.P.': [2341], 'Ramabhadran': [2342], 'T.V.': [2343], 'Unterbeck': [2344], 'Greengard': [2346, 2375, 2424], '1990;': [2355], '87:': [2356], '6003-6006Crossref': [2357], '(426)': [2360], '32Xu': [2363], 'Sweeney': [2365], 'A.C.': [2372], 'Sisodia': [2373, 2406], 'S.S.': [2374, 2407], '1997;': [2386], '94:': [2387], '3748-3752Crossref': [2388], '(251)': [2391], '33Thinakaran': [2394], 'Regard': [2396], 'Bouton': [2398], 'Harris': [2400], 'C.L.': [2401], '438-453Crossref': [2412], '(171)': [2415], '34Yan': [2418], 'Han': [2420], '36788-36796Abstract': [2433], '(158)': [2441], 'anti-TACE': [2445], 'Santa': [2449], 'Cruz': [2450], 'Biotechnology': [2451], '(Santa': [2452], 'Cruz,': [2453], 'anti-α-tubulin': [2456], 'Sigma.': [2460], 'Monoclonal': [2461], 'antibodies': [2462], '6E10': [2463], '4G8': [2465], '(Signet': [2466], 'Laboratories,': [2467], 'Dedham,': [2468], 'MA)': [2469], 'recognize': [2471], 'amino': [2472], 'acids': [2473], '1–17': [2474], '17–24': [2476], 'peptide,': [2480], 'respectively,': [2481], 'detect': [2485], 'βCTFs.Aβ': [2489], 'ELISA': [2490, 2510], 'Assay—Conditioned': [2491], 'media': [2492], 'hypoxia-treated': [2494, 2524, 2553, 3532, 3610, 3683, 3723], 'untreated': [2496, 2526, 2555, 2644, 3525, 3534, 3669, 3685, 3703, 3725, 3884, 3905], 'collected.': [2499], 'concentrations': [2501], 'Aβ42': [2505], 'quantified': [2507, 2625, 3652], 'commercial': [2509], 'kits': [2511], 'protocols.In': [2518], 'Vitro': [2519], 'β-Secretase': [2520], 'Activity': [2521, 3253], 'Assay—Lysates': [2522], 'assayed': [2529, 2894], 'kit': [2535, 2668, 2986], 'Calbiochem': [2537], '(San': [2538], 'Diego,': [2539], 'protocol.Pulse-Chase': [2544], 'Experiments—To': [2545], 'kinetics': [2548], 'metabolism,': [2551], '4-h': [2552, 3609], 'labeled': [2559, 2636, 3083, 3662, 4219], '[35S]methionine': [2561, 3490, 3598, 3616], '(500': [2562, 3599], 'μCi/ml)': [2563, 3600], '5': [2565, 2639, 3492, 3602, 3665, 4310], 'min': [2568, 2593, 2605, 2640, 3495, 3500, 3508, 3619, 3666], 'collected': [2573], 'analysis.': [2575, 3947], 'experiments,': [2578, 3608], 'pretreated': [2582, 3484], '4': [2584, 2888, 2978, 3592, 3971, 4159, 4234], 'subjected': [2590], '15': [2592, 3499, 3618], 'pulse-labeling': [2595], 'followed': [2596, 2617, 3501, 3643], 'chase': [2598, 3503], '15,': [2600], '30,': [2601], '60,': [2602], '120': [2604, 3507], 'conditions.': [2608, 3629, 3791], 'immunoprecipitated': [2612, 3638], 'SDS-PAGE': [2619, 3645], 'autoradiography.': [2622, 3648], 'Data': [2623, 3710, 4176], 'Scion': [2627], 'Image': [2628, 3732, 4265], '(Scion': [2629], 'Corp.,': [2630], 'Frederick,': [2631], 'MD).': [2632], 'labeling': [2642, 3667], 'defined': [2647, 3672], 'one': [2649, 3674, 3707], 'arbitrary': [2650, 3675, 3708], 'unit.Quantitative': [2651], 'Real-time': [2652], 'Polymerase': [2653], 'Chain': [2654], 'Reaction': [2655], '(RT-PCR)—Total': [2656], 'RNA': [2657, 3112, 3242, 3679], 'extracted': [2659, 3681], 'TRIzol': [2661], 'reagent': [2662, 3155], 'SuperScript': [2666], 'First-Strand': [2667], '(Invitrogen)': [2669, 2834], 'synthesize': [2673], 'strand': [2675, 3813, 4089], 'samples': [2678, 3726], 'equal': [2681], 'amount': [2682], 'RNA,': [2684], 'according': [2685], 'instruction.': [2689], 'Synthesized': [2690], 'cDNAs': [2691], 'amplified': [2693], 'IQ™': [2695], 'SYBR': [2696], 'green': [2697], 'supermix': [2698], 'ICycler': [2700], 'Bio-Rad;': [2702], 'data': [2703, 4048, 4169], 'Bio-Rad': [2707], 'MyIQ': [2708], '2.0.': [2709], 'Primers': [2710, 2721, 2790], 'amplification': [2714, 2725, 2811], 'were:': [2715, 2726], 'BACE1–5,': [2716], '5′-GATGGTGGACAACCTGAG-3′': [2717], 'BACE1–3,': [2719], '5′-CTGGTAGTAGCGATGCAG-3′.': [2720], 'β-actin': [2724, 3699], 'actin-5,': [2727], '5′-AGCCATGTACGTAGCCATCC-3′': [2728], 'actin-3,': [2730], '5′-CTCTCAGCTGTGGTGGTGAA-3′.': [2731], 'normalized': [2736, 2896, 3697, 4171], 'β-actin.': [2740], 'Three': [2741], 'independent': [2742, 3717], 'experiments': [2743], 'performed,': [2745], 'statistical': [2747], 'carried': [2750], 'out': [2751], "Student's": [2754], 't': [2755], 'test.Construction': [2756], 'Luciferase': [2758], 'Reporter': [2759], 'Plasmids,': [2760], 'Site-directed': [2761], 'Mutagenesis,': [2762], 'Electrophoretic': [2764], 'Mobility': [2765], 'Shift': [2766, 3070], 'Assay': [2767, 3071], '(EMSA)—PCR': [2768], 'performed': [2770, 2903, 3944, 4239], 'amplify': [2772], '5′-flanking': [2774, 3797], 'region': [2775, 3774, 3847, 3873], 'gene': [2779, 2858, 2873, 3803], 'genomic': [2782], 'DNA': [2783, 4122], 'template.': [2789], 'primer5,': [2794, 2802], '5′-GGCTGGCATGCATGACAGGGTGCGCACGGGGGTGTG-3′': [2795], 'primer3,': [2798], '5′-CAGCACCTAGGCAGGCTGGGGAGGCGGAAAGGCTTG-3′.': [2799], 'mutBACE': [2801], '5′-GGCTGGCATGCATGACAGGGTGCGTCACGGGGTGTG-3′,': [2803], 'paired': [2805], 'primer3': [2808], 'PCR': [2810, 2826, 3554], 'introduce': [2813], 'mutations': [2814], '(boldface': [2815, 3030], 'underlined)': [2817, 3032], 'into': [2818, 2830, 2850, 2875, 3150, 3861, 4146], 'potential': [2820, 3011, 3766, 3806, 4081], 'site.': [2823, 3929], 'After': [2824, 2837], 'amplification,': [2825], 'products': [2827], 'inserted': [2829], 'pCR2.1-TOPO': [2832], 'vector': [2833, 2853], 'sequencing.': [2836], 'vectors': [2841, 2864, 3844], 'KpnI': [2843], 'XhoI,': [2845], 'released': [2846], 'fragments': [2847], 'introduced': [2849], 'pGL3-enhancer': [2852], 'firefly': [2856], 'luciferase': [2857, 2863, 2872, 2891, 3842, 4125, 4143, 4162, 4174], '(Promega,': [2859], 'Madison,': [2860], 'WI).': [2861], 'Firefly': [2862, 2890], 'co-transfected': [2866, 4139], 'phRL-SV40': [2868], 'Renilla': [2871, 2900, 4142, 4173], '(Promega)': [2874], 'cells,': [2877, 3526], 'treated': [2882, 2974, 3273, 3520, 3588, 3879, 3967, 4153, 4230], 'without': [2885, 3094, 3496, 4156], 'h.': [2889, 3292, 4160, 4235], 'activities': [2892], 'those': [2898, 4288], 'luciferase.EMSA': [2901], 'previously': [2905, 3413], 'described': [2906], '35Wang': [2937], 'Sun': [2941], 'Cell.': [2958, 3130], '26:': [2961], '1347-1354Crossref': [2962], '(38)': [2965], 'Briefly,': [2968], 'nuclear': [2969, 2984, 3090, 3962, 4064, 4225], 'extracts': [2970, 3091, 3963, 4226], 'prepared': [2981], 'extract': [2985], '(Activemotif,': [2987], 'Oligonucleotides': [2990], 'synthesized': [2992], 'annealed': [2994], 'their': [2996], 'respective': [2997], 'reverse': [2998], 'complements': [2999], 'double-stranded': [3004], 'oligonucleotides:': [3005], 'wild-type': [3006, 4249], 'site': [3014, 3809, 3834, 3895, 3939, 4073, 4084, 4102, 4109, 4197], '(5′-CAGGGTGCGCACGGGGGTGTGGG-3′);': [3020], 'mutant': [3021, 3102, 3850, 3918, 4034, 4133, 4255], 'CACG': [3026], '→': [3027], 'TCAC': [3028], 'mutation': [3029, 3889], '(5′-CAGGGTGCGTCACGGGGTGTGGG-3′);': [3033], 'consensus': [3037, 3063, 3987, 4011, 4203, 4243], 'probe': [3038, 3064, 3960, 4012, 4016, 4035, 4042, 4206, 4215, 4244, 4250, 4256, 4261], '(5′-ACCGGCCCTACGTGCTGTCTCAC-3′)': [3039], '(37Chun': [3040], 'Y.S.': [3041], 'Choi': [3042], 'Yeo': [3044], 'E.J.': [3045], 'Lee': [3046], 'J.H.': [3047], 'Kim': [3048], 'M.S.': [3049], 'Park': [3050], '114:': [3056], '4051-4061Crossref': [3057], 'provided': [3066], 'Gel': [3069], 'Core': [3072], 'System': [3073], '(Promega).': [3074], 'Wild-type': [3075], 'probes': [3081], '[γ-32P]ATP': [3085, 4221], 'unlabeled': [3095, 4009, 4031, 4241], 'competitor': [3098], '(wild': [3099], 'type': [3100, 4131], 'form).': [3103], 'Samples': [3104, 3231], 'non-denaturing': [3108], 'PAGE': [3109], 'autoradiography.HIF-1α': [3111], 'Interference—The': [3113], 'siRNA': [3116, 3142, 3147], 'sequence': [3117, 3143, 3793, 3798], '5′-AAGCAUUUCUCUCAUUUCCUCAUGG-3′': [3120], '(38Ono': [3121], 'Sensui': [3123], 'Sakamoto': [3125], 'Nagatomi': [3127], '98:': [3133], '642-649Crossref': [3134], '(39)': [3137], 'control': [3141], 'Invitrogen.': [3146], 'Lipofectamine': [3153], 'RNAiMAX': [3154], '(Invitrogen),': [3156], 'protocol.Tissue': [3160], 'Isolation': [3161], 'Conditional': [3164], 'Knock-out': [3165], 'Mice—The': [3166], 'dissected': [3171], 'mice': [3176], '(in': [3177], 'Cre': [3179], 'driven': [3181], 'calcium/calmodulin-dependent': [3184], 'kinase': [3185], 'CaMKIIα': [3186], 'promoter)': [3187], 'littermates': [3189], '2': [3191, 4334], 'months': [3192], 'age': [3194], '(39Helton': [3195], 'Cui': [3197], 'Scheel': [3199], 'Ellison': [3201], 'Ames': [3203], 'Gibson': [3205], 'Blouw': [3207], 'Ouyang': [3209], 'Dragatsis': [3211], 'Zeitlin': [3213], 'Lipton': [3217], 'Barlow': [3219], '25:': [3224], '4099-4107Crossref': [3225], '(227)': [3228], 'either': [3233], 'immunoblotting': [3238], 'extraction': [3243], 'quantitative': [3245, 3690], 'RT-PCR.RESULTSAcute': [3246], 'Increases': [3248], 'Protein': [3250], 'Level': [3251, 4274], 'Up-regulating': [3257], 'Its': [3258], 'Transcription—To': [3259], 'analyze': [3260], 'proteins': [3267], 'involved': [3268], '(1%': [3285], 'O2)': [3286], 'As': [3293, 3864], 'shown': [3294, 4313], 'Fig.': [3296, 3992], '1A,': [3297], 'BACE1,': [3305, 3444], 'accompanied': [3306], 'concomitant': [3309], 'expected.': [3316], '(PS1-NTF)': [3326], 'full-length': [3328], 'treatment.': [3335], 'A': [3336, 4362], 'modest': [3337, 3416], 'observed,': [3346], 'reflecting': [3347], '(Fig.': [3352, 3406, 3453, 3550, 3573, 3828, 3886, 3919, 3973, 4017, 4036, 4043, 4360], '1B).': [3353], 'Consistent': [3354], 'previous': [3357], 'observation': [3358, 4366], 'led': [3391], 'marked': [3394], 'overall': [3397], 'secreted': [3400], '(both': [3402], 'Aβ42)': [3405], '1,': [3407, 4300], 'D).': [3410], 'While': [3411], 'decrease': [3417], 'CTFs': [3422], 'HeLa': [3424], 'chemical': [3427], 'hypoxia,': [3428, 4290], 'current': [3430], 'study': [3431], 'showed': [3432, 3556], 'slight': [3434], 'βCTF,': [3438], 'immediate': [3440], 'product': [3442], 'treatments': [3449], '1C).The': [3454], 'steady': [3456], 'state': [3457], 'result': [3462], 'biogenesis,': [3465], 'decreased': [3466], 'degradation,': [3467], 'both.': [3469], 'To': [3470, 3830, 3930], 'determine': [3471, 3831, 4277], 'step(s)': [3474], 'affects': [3476, 3542], 'undertook': [3480], 'pulsechase': [3481], 'experiments.': [3482, 3718], 'pulse-labeled': [3488, 3596, 3614], 'chase,': [3497], 'periods': [3504, 3626], 'up': [3505], 'Biosynthesis': [3511], 'nascent': [3513], 'higher': [3517, 3876, 4369], 'than': [3523, 3545, 3882], 'turnover': [3528], 'curves': [3529], 'both': [3531, 3859], 'similar,': [3537], 'mainly': [3541], 'biosynthesis': [3543], 'rather': [3544], 'degradation': [3546], '2A).': [3551], 'Quantitative': [3552], '1.5–2-fold': [3557], 'confirming': [3565], '2B).FIGURE': [3574], '2Acute': [3575], 'biogenesis': [3578], 'transcription.': [3583], 'A,': [3584, 4079], 'min.': [3605], 'chased': [3622], 'various': [3624, 4296], 'time': [3625, 3729], 'antibody,': [3642], '(by': [3653], 'densitometry': [3654], 'autoradiographic': [3656], 'bands),': [3657], 'unit.': [3676], 'B,': [3677, 4124], 'reverse-transcribed': [3688], 'real': [3691], 'time-PCR.': [3692], 'compared': [3701], 'controls': [3704], '(defined': [3705, 3825, 4103], 'unit).': [3709], 'represent': [3711, 4117, 4177], 'means': [3712, 4178], '±': [3713, 4179], 'three': [3716], '*,': [3719, 4181], 'p': [3720, 4182], '<': [3721, 4183], '0.05,': [3722], 'versus': [3724, 4185], 'indicated': [3728], 'point.View': [3730], 'Large': [3731, 4264], 'Figure': [3733, 4266], 'ViewerDownload': [3734, 4267], 'Hi-res': [3735, 4268], 'image': [3736, 4269], 'Download': [3737, 4270], '(PPT)Identification': [3738], 'Functional': [3741], 'Binding': [3743], 'Element': [3744], 'Promoter—Given': [3748], 'critical': [3753], 'activated': [3756], 'response': [3758], 'stresses,': [3761], 'looked': [3763], 'element': [3769, 4058], 'asked': [3776], 'whether': [3777, 3832, 4278], 'could': [3781], 'responsible': [3783], 'up-regulation': [3785], 'Indeed,': [3792], 'minus': [3812, 4088], '–835': [3815], '–821': [3817], '(acgcGTGCccccaca)': [3818], 'upstream': [3819], 'start': [3823, 4101], 'ATG': [3824], '+1)': [3827], '3A).': [3829], 'this': [3833, 3846, 3870, 3917, 3927, 3936, 3959], 'activity,': [3839], 'constructed': [3841], 'reporter': [3843, 4126, 4144], 'lacks': [3853], 'ability': [3856], 'constructs': [3860], 'cells.': [3863], 'expected,': [3865], '3B).': [3887, 3920], 'resulted': [3896], 'did': [3909], 'functionality': [3925], 'investigate': [3932], 'interaction': [3934], 'Such': [3948], 'DNA-protein': [3953], 'forming': [3955], 'incubation': [3957], '3C,': [3974, 3993, 4018, 4037, 4044], 'lane': [3975, 3994, 4038, 4045, 4208], '2).': [3976], 'This': [3977], 'migrated': [3979], 'same': [3982], 'position': [3983], 'probe-protein': [3988, 4001], '(positive': [3990], 'control,': [3991], '1).': [3995], 'Formation': [3996], 'abolished': [4004], 'competitive': [4006], 'lanes': [4019], '3': [4020], '4)': [4022], 'presence': [4029], '5)': [4039], '6).': [4046], 'support': [4049], 'idea': [4051], 'protein.FIGURE': [4066], '3Identification': [4067], 'Numbering': [4095], 'relative': [4097], 'translation': [4100], '+1).': [4105], 'underlined': [4111], 'boldface.': [4114], 'Small': [4115], 'capitals': [4116], 'sites': [4118], 'mutated': [4119], 'block': [4121], 'binding.': [4123], 'plasmids': [4127], 'carrying': [4128], 'wild': [4130, 4187], 'plasmid': [4145], 'cells;': [4148], 'Relative': [4161], 'determined': [4165], 'triplicate,': [4167], 'activity.': [4175], '0.05': [4184], 'type.': [4188], 'C,': [4189], 'assays': [4192, 4237], '(P,': [4207], '1)': [4209], '(lane': [4216, 4245, 4251, 4257, 4262], '2)': [4217], 'Competition': [4236], '3),': [4246], '4),': [4252], '5),': [4258], '6).View': [4263], '(PPT)HIF-1α': [4271], 'Regulates': [4272], 'BACE1—To': [4276], 'mediates': [4281], 'similar': [4286], 'doses': [4297], '(0,': [4298], '0.5,': [4299], '5,': [4302], 'μg;': [4305], 'only': [4306], '0,': [4307], 'μg': [4311, 4335], 'here)': [4314], 'cDNA.': [4317], 'Following': [4318], 'maximum': [4324], '∼2.5-fold': [4327], 'DNA.': [4338], '2-fold': [4343], 'along': [4349], 'minimal': [4351], 'changes': [4352], 'NTF': [4357], 'TACE': [4359], 'B).': [4364], 'dose': [4370], '(5': [4371], 'μg)': [4372], 'HI': [4374]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2030333049', 'counts_by_year': [{'year': 2024, 'cited_by_count': 22}, {'year': 2023, 'cited_by_count': 19}, {'year': 2022, 'cited_by_count': 23}, {'year': 2021, 'cited_by_count': 24}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 26}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 19}, {'year': 2015, 'cited_by_count': 28}, {'year': 2014, 'cited_by_count': 33}, {'year': 2013, 'cited_by_count': 23}, {'year': 2012, 'cited_by_count': 30}], 'updated_date': '2024-12-24T15:18:00.431762', 'created_date': '2016-06-24'}